| half-life of platelet factor 4 (pf-4) in plasma and platelets from macaca mulatta. | human platelet factor 4 (pf-4) showed a reaction of complete identity with pf-4 from macaca mulatta when tested against rabbit anti-human-pf-4. such immunoglobulin was used for quantitative precipitation of in vivo labelled pf-4 in monkey serum. the results suggest that the active protein had an intra-platelet half-life of about 21 hours. in vitro 125i-labelled human pf-4 was injected intravenously into two monkeys and isolated by immuno-precipitation from platelet-poor plasma and from platelets ... | 1977 | 402708 |
| diurnal variations of serum testosterone levels in intact and gonadectomized male and female rhesus monkeys. | a radioimmunoassay for serum testosterone which does not require chromatographic separation was used to measure the diurnal variations in intact and orchidecomized males and intact and ovariectomized females. the intact male rhesus monkey shows a distinctive diurnal variation in serum levels of testosterone characterized by lower values during the day and a marked increase in the early evening (1900-2200 hr). the testosterone levels remain high throughout most of the lights-off period in the int ... | 1977 | 402717 |
| corpus luteum function during the early postpartum interval in lactating rhesus monkeys: in vivo and in vitro response to exogenous gonadotropin. | the response of the postpartum corpus luteum to exogenous gonadotropin was studied in 12 lactating rhesus monkeys given daily injections of either human chorionic gonadotropin (hcg, n = 6) or saline (control, n = 6) for 4 days immediately following parturition. peripheral blood samples were collected daily. on the 5th day postpartum, luteectomy was performed progesterone production by dispersed luteal cells was examined. whereas progesterone in the peripheral circulation of control monkeys progr ... | 1977 | 402718 |
| cholesterol side chain cleavage and aromatase activities in the corpus luteum of the pregnant rhesus monkey. | cholesterol side-chain cleavage (cscc) and aromatase activities were measured in luteal mitochondria and tissue pieces, respectively, from rhesus monkeys on days 22, 49, 128 and 160 of gestation. cscc activity did not vary significantly during gestation and thus probably does not respond to chorionic gonadotropin which is elevated on day 22 of pregnancy. it is not known, however, whether cscc can be stimulated prior to day 22 when the corpus luteum is steroidogenically more active. both 3h-pregn ... | 1977 | 402720 |
| placental and luteal steroidogenesis in the pregnant rhesus monkey. | progesterone, 20alpha-dihydroprogesterone, estrone and estradiol-17beta concentrations were estimated by radioimmunoassay in blood plasma from uterine, uteroovarian and femoral veins of rhesus monkeys (macaca mulatta) on days 22, 49, 128 and 160 of gestation. steroids were consistently more concentrated in uterine and uteroovarian that in femoral venous plasma and in many cases levels in the uteroovarian vein were also higher than those in the uterine vein indicating luteal secretion of both pro ... | 1977 | 402721 |
| menopause in rhesus monkeys: model for study of disorders in the human climacteric. | hormonal and menstrual patterns were studied in rhesus monkeys 22 years of age or older. sustained elevations of serum gonodotropins, low circulating levels of estradiol and progesterone, associated with oligomenorrhea or amneorrhea, were similar to changes reported for peri- and postmenopausal women. during the menopausal transition, pituitary fsh appears to be modulated independently of lh. these observations suggest that the rhesus monkey may be a suitable model for study of disorders afflict ... | 1977 | 402812 |
| lack of effect of human chorionic gonadotropin on serum estrogen levels in ovariectomized rhesus monkeys. | | 1977 | 402813 |
| central-nervous-system toxicity of local anesthetic mixtures in monkeys. | the central-nervous-system toxicities of local anesthetic mixtures consisting of lidocaine and etidocaine or lidocaine and tetracaine, administered intravenously to four healthy, non-medicated rhesus monkeys, were evaluated. toxicities were compared by determining seizure dosages for each drug alone and then in a lidocaine-etidocaine-tetracaine mixture. arterial plasma levels of lidocaine and etidocaine at which electrical seizure activity occurred also were measured when the drugs were administ ... | 1977 | 402868 |
| fate and distribution of inhaled nitrogen dioxide in rhesus monkeys. | the intra- and extrapulmonary distributions of inspired nitrogen dioxide (no2) were studied by exposing rhesus monkeys to air mixtures containing concentrations slightly greater than ambient (0.56 to 1.71 mg per m3, or 0.30 to 0.91 ppm) of no2 labeled with tracer quantities of no2 containing nitrogen-13 dioxide (13no2). the 13no2 (half-time, 10 min) was synthesized by the oxygen-16 (p, alpha)13n nuclear reaction in an isochronous cyclotron. the intrapulmonary location and concentration of the in ... | 1977 | 402875 |
| effect of metoprolol and oxprenolol on delayed differentiation behaviour in the monkey (macaca mulatta) [proceedings]. | | 1977 | 402968 |
| columnar distribution of cortico-cortical fibers in the frontal association, limbic, and motor cortex of the developing rhesus monkey. | the terminal distribution of cortico-cortical connections was examined by autoradiography 7-8 days following injections of tritium labeled amino acids into the dorsal bank of the principal sulcus, the posterior part of the medial orbital gyrus, or the hand and arm area of the primary motor cortex in monkeys ranging in age from 4 days to 5.5 months. labeled axons originating in these various regions of the frontal lobe have topographically diverse ipsilateral and contralateral destinations but vi ... | 1977 | 402978 |
| effect of lid suture on retinal ganglion cells in macaca mulatta. | previous work has established the pronounced effect of unilateral lid suture during visual immaturity on cell growth in the lateral geniculate nucleus of cats, dogs and monkeys. most investigators have reported the retinas to be grossly normal but only a few quantitative studies are available and the results are contradictory. we have compared cell section diameters and cell density of parafoveal retinal ganglion cells in the deprived and non-deprived eye of macaca mulatta after the lids of one ... | 1977 | 402979 |
| heterogeneous afferents to the inferior parietal lobule of the rhesus monkey revealed by the retrograde transport method. | the sources of afferent connections to the inferior parietal lobule (rostral part of the area 7 of brodman; pf and rostral part of pg of von bonin and bailey) were examined with the retrograde transport method in infant and adult rhesus monkeys. two to 3 days after injections of horseradish peroxidase (hrp) into the cortex, the animals were anesthetized, and the brains fixed and processed for the histochemical demonstration of the enzyme marker. labeled neurons were found in layer iii in the ips ... | 1977 | 402983 |
| long-term studies on rhesus monkeys (macaca mulatta) immunized against plasmodium knowlesi. | studies carried out on four rhesus monkeys (macaca mulatta) that had been vaccinated against plasmodium knowlesi show that the immunized animals were protected against a challenge with a heterologous strain of p. knowlesi. this protection was shown to be present even 4 years after the immunization schedule has been completed. the effect could not be attributed toprevious infections with the parasite, since four control rhesus monkeys that had recovered from one to four challenges with p. knowles ... | 1977 | 403136 |
| regeneration of corneal epithelial basement membrane following thermal cauterization. | thermal cauterization of the corneas of nine rhesus monkeys was performed by multiple thermokeratophore applications at temperatures of 90 degrees or 120 degrees c. significant clinical observations included the resteepening of corneal curvature, delayed epithelial healing, stromal haze or scarring, and peripheral neovascularization. reestablishment of tight adhesion of the regenerated epithelium to bowman's layer required approximately 6 weeks. by transmission and scanning electron microscopy, ... | 1977 | 403153 |
| fatigue characteristics of posterior elements of vertebrae. | the fatigue strength of vertebral posterior elements was determined by applying repetitive forces to the inferior joints between the articular processes of human rhesus-monkey vertebrae. the results indicate that in vivo stresses resulting from unusual activities for sustained periods can induce fatigue fracture of the lumbar vertebrae. comparison of these data with those of other investigators suggests the use of ultimate strength as a normalizing factor to correlate fatigue-strength data obtai ... | 1977 | 403190 |
| response characteristics of cutaneous cold receptors in the monkey. | 1. the receptive fields of 48 specific cold units, located in the hairy and glaborous skin of fore- and hindlimbs of rhesus monkeys, were mapped and scale drawings made. forty-five percent had single spotlike receptive fields of 1-2 mm diameter or were up to 2 mm wide and 3-5 mm long, and formed straight, crescent, or right-angle shapes. the remaining 55% had two to five discrete spots or small areas innervated by a single fiber. area or number of receptive fields per unit did not vary significa ... | 1977 | 403250 |
| properties and tectal projections of monkey retinal ganglion cells. | 1. extracellular single-unit recordings were undertaken in the retina of the rhesus monkey in order to assess the receptive-field properties of those ganglion cells which project to the superior colliculus. cells were tested for antidromic activation from the superior colliculus, lateral geniculate nucleus, and the optic chiasm. 2. the majority of retinal ganglion cells could be classified as color opponent or broad band. a small, heterogeneous group could not be so classified and were collectiv ... | 1977 | 403252 |
| release of antidiuretic hormone during mass-induced elevation of intracranial pressure. | there are complex osmotic and non-osmotic factors regulating release of antidiuretic hormone (adh). a wide variety of intracranial pathological processes may trigger adh release sufficient to produce clinically recognizable hyponatremia, or the "inappropriate adh syndrome." we systematically studied one non-osmotic trigger, namely mass-induced elevated intracranial pressure (icp). initial experiments established baseline data in normal rhesus monkeys: anesthetized animals displayed appropriate ... | 1977 | 403253 |
| biologic basis for modification of the sagittal ramus split operation. | ten adult rhesus monkeys were used as experimental models to investigate revascularization and bone healing associated with sagittal splitting of the mandibular rami by two different techniques. microangiographic and histologic studies showed intraosseous ischemia in the margins of the osteotomized segments and areas where the pterygomasseteric sling had been detached. when the mucoperiosteum and pterygomasseteric sling were minimally detached from the proximal segment, intraosseous ischemia and ... | 1977 | 403263 |
| host range characteristics of the primate coccidian, isospora arctopitheci rodhain 1933 (protozoa: eimeriidae). | studies were conducted on 35 primates, 12 carnivores, and 2 marsupials to determine their susceptibility to the primate coccidian, isospora arctopitheci. patent oocyst infections resulted in 12 of the 14 species of animals investigated. these included 6 genera of new world primates native to panama: saguinus geoffroyi, aotus trivirgatus, ateles fusciceps, cebus capucinus, alouatta villosa, and saimiri sciureus. in addition 4 families of carnivores (2 domestic and 2 sylvatic) and 1 species of mar ... | 1977 | 403270 |
| concentration-time effects of quinidine disposition kinetics in rhesus monkeys. | the effects of dose and duration of drug administration (time) on the disposition kinetics of quinidine were investigated in unanesthetized rhesus monkeys. a specific thin-layer chromatography-fluorometric assay was developed for the determination of quinidine in plasma, blood and urine. after the monkeys receive an i.v. bolus dose of 3 to 7 mg/kg, quinidine distributes rapidly in the body (t 1/2alpha = 2 minutes). the half-life associated with elimination (t 1/2 beta) was 27 to 35 minutes and p ... | 1977 | 403278 |
| reinforcing properties of perphenazine, haloperidol and amitryptiline in rhesus monkeys. | possible negative reinforcing effects of perphenazine, haloperidol and amitryptiline were studied in rhesus monkeys previously trained to avoid electric shock by responding. responding extinguished a light associated with an intravenous drug infusion scheduled to occur 30 seconds after the light was switched on. a response occurring when the light was on switched the light off for a period of 1 minute (time-out period). a response during the infusion terminated the infusion. under these conditio ... | 1977 | 403280 |
| a comparative study of experimental and spontaneous emphysema. | normal lung architecture of the rat, mouse, hamster, horse, and human was compared to that of emphysematous lungs from the same species by utilizing a light microscope and a scanning electron microscope (sem). the results obtained by sem examination of normal and emphysematous lungs corresponded to those obtained with the light microscope. however, the sem provided a view of alveoli and airway morphology not obtainable with the light microscope. because of the variability in pore size and number ... | 1977 | 403296 |
| studies of rhesus monkey (macaca mulatta) hemoglobin. | one hemaglobin was found in the adult rhesus monkey (macaca mulatta) by the technique of isoelectric focusing. in addition to the adult hemoglobin, one fetal hemaglobin was observed in neonates of the same species. the alpha and non-alpha globins of rhesus monkey hemoglobins showed similar electrophoretic mobilities as those of human hemoglobin a by cellulose acetate membrane electrophoresis. it appeared that the rhesus monkey hemoglobin system is a good model system for the study of human hemog ... | 1977 | 403373 |
| clinical manifestations of chronic thiamine deficiency in rhesus monkey. | in the course of multiple episodes of thiamine deficiency in the rhesus monkey, the triad of anorexia, apathy, and hind limb weakness is the earliest clinical manifestation. in later episodes, nystagmus, abducens paresis, midline ataxia, dysmetria, and congestive heart failure are also seen. with the exception of dysmetria, the neurologic signs promptly respond to thiamine administration. pair-fed controls showed no clinical signs. neither peripheral neuropathy nor edema was observed. thiamine-d ... | 1977 | 403480 |
| vesicoureteral reflux in the primate: ii maturation of the ureterovesical junction. | infant rhesus monkeys frequently show vesicoureteral reflux unlike adults. we studied monkeys born of mothers who had been on normal or protein-deficient diets. protein deficiency may influence the time that reflux continues, but this was not statistically proved. reflux disappears over time. the time was influenced by when the pregnancy was initiated and the maturity of the infant. maturation as measured by skeletal maturity scores correlated well with the time of reflux, but growth as measured ... | 1977 | 403505 |
| an investigation of nalorphine and perphenazine as negative reinforcers in an escape paradigm. | rhesus monkeys were trained to self-administer morphine intravenously at dose levels sufficient to develop physical dependence. the monkeys were then trained to press a lever to escape a continuous infusion of the morphine antagonist, nalorphine. when saline was substituted for the nalorphine, escape responding extinguished. after morphine self-administration was eliminated, responding to escape from nalorphine was maintained in the postdependent monkeys, showing no difference from escape respon ... | 1977 | 403529 |
| behavior maintained under second-order schedules of intravenous morphine injection in squirrel and rhesus monkeys. | under second-order schedules of morphine injection, high rates of responding by squirrel and rhesus monkeys were maintained when morphine was injected intravenously only at the end of each session. every 30th key-pressing response during a 60-min interval produced a 2-s light; the first 30-response component completed after 60 min produced both the light and intravenous injection of morphine. a mean rate of approximately one response per second was maintained by doses of morphine ranging from 0. ... | 1977 | 403538 |
| scotopic vision deficits in young monkeys exposed to lead. | rhesus monkeys were reared on diets designed to produce blood lead concentrations of 14 (untreated), 55, or 85 micrograms per 100 milliliters for the first year of life. eighteen months later, blood lead levels were normal in all animals. at this time, however, visual discrimination performance in the 85-microgram group was impaired under dim light relative both to their own performance under bright light and to the performance of the other groups under all light levels used. we interpret these ... | 1977 | 403610 |
| the major histocompatibility complex of rhesus monkeys, rhl--a. vii. identification of five new serologically defined antigens. | five new serologically defined (sd) tissue antigens of rhesus monkeys are described. results of a population study and a segregation analysis in families were consistent with their control by the major histocompatibility complex (mhc), as alleles of the two previously established sd loci of rhl--a. the number of identifiable sd specificities of the rhesus monkeys' mhc is now twenty-five, thirteen controlled by the sd1 locus and twelve by sd2. the recombination frequency between sd1 and sd2 is es ... | 1977 | 403633 |
| stochastic analysis of 133xe clearance for determining regional cerebral blood flow in a primate model. | a technique for stochastic analysis of 133xe washout using a computer-assisted anger camera is described. the technique produces functional maps of both regional cerebral blood flow (rcbf) and error in rcbf. the calculational limitations of the technique are discussed and an experimental estimate made of the physical limitations associated with the low energy photon emitted by 133xe. the method is demonstrated in a rhesus monkey model before and after surgical occlusion of the middle cerebral ar ... | 1977 | 403639 |
| metabolic disposition of 6-chloro-5-cyclohexyl-1-indancarboxylic acid (tai-284), a new non-steroidal anti-inflammatory agent, in rhesus monkeys. | 1. after oral administration of 6-chloro-5-cyclohexyl-1-indan[14c]carboxylic acid (tai-284) to rhesus monkeys, the plasma concn. reached a plateau at 2 h, which persisted for 4 h and then declined with an approximate half-life of 24 h. more than 92% of the plasma radioactivity was derived from unchanged tai-284. the plasma concn. of the ulcerogenic metabolite, 6-chloro-5-(cis-3'-hydroxycyclohexyl)-1-indancarboxylic acid (metabolite iib), was much lower in monkeys than in rats. 2. in monkeys, eli ... | 1977 | 403686 |
| light and electron microscopical study on sarcocysts from muscles of the rhesus monkey (macaca mulatta), baboon (papio cynocephalus) and tamarin (saguinus(=oedipomidas) oedipus). | sarcocystis cysts from muscles of monkeys (baboon, tamarin and rhesus monkey) were studied by means of light and electron microscopy. the differences in the morphology of the cyst wall and parasites clearly indicate that the three monkey species examined were each parasitized by at least a specific sarcocystis species being not identical with s. nesbitti or s. kortei. the large numbers of cysts found within the muscle fibres point out the important role that have these monkeys as intermediate ho ... | 1977 | 403695 |
| [on the transplacental induction of tumours by n-ethyl--n-nitrosourea in different species (author's transl)]. | the transplacental activity of n-ethyl-n-nitrosourea (enu) was tested in rats, rabbits, syrian golden hamsters, dzungarian dwarf hamsters, guinea pigs, dogs, and rhesus monkeys. in the offspring of rats, multiple tumours of the central and peripheral nervous system were found in 100 per cent, whereas in rabbits kidney tumours developed. in syrian golden hamsters, the application led mostly to neoplasms of the thyroid gland. dzungarian dwarf hamsters and monkeys prooved to be resistant. 9 out of ... | 1977 | 403705 |
| an experimental study of increased vertical dimension in the growing face. | five juvenile rhesus monkeys were used in an experiment designed to study the structural adaptations in the craniofacial complex that resulted from increases in vertical dimension. the bite was opened 2,3,10, or 15 mm. by means of cast bite splints cemented on the maxillary arch. adaptations were monitored in these animals by means of serial cephalometric radiography with metallic implants. the results of this study indicate that any change in the vertical dimension of the face results in specif ... | 1977 | 403768 |
| experimental repair of orbital floor fractures. | eight rhesus monkeys (16 orbits) were used to evaluate the treatment of experimentally created orbital floor fractures. the fractures were repaired with antral bone, silastic, and gelatin film implants and studied clinically and histologically. four orbits were used as controls. all implants appeared to favorably influence healing by preventing entrapment of the orbital contents within the reparative tissue. autogenous bone appeared to be the best implant. silastic and gelatin film were also eff ... | 1977 | 403901 |
| alternobaric effects on the endolymph. | hearing loss and vertigo experienced as a result of environmental pressure change has been the subject of many superficial inquiries. the mechanism of these conditions remains obscure. in human volunteers and a rhesus monkey, the effects of intratympanic as well as ear canal pressure changes on the endolymphatic system were measured using electronystagmography (eng). for the monkey histological evaluation of the pressure effects on auditory structures was performed. we were unable to cause any e ... | 1977 | 403903 |
| endocrine characterization of the menstrual cycle of the stumptailed monkey (macaca arctoides). | the endocrine characterization of the menstrual cycle of the stumptailed monkey was determined and compared with that of the rhesus monkey. serum concentrations of luteinizing hormone (lh), estradiol-17beta, and progesterone were determined on a daily basis from 5 monkeys. differences included: 1) basal and peak concentrations of lh 40% of those in rhesus monkeys, 2) an estraidol peak occurring on the day proceding lh peak, 3) an estradiol peak on the 3rd day after lh surge and representing t ... | 1977 | 403966 |
| catecholamines in neocortex of rhesus monkeys: regional distribution and ontogenetic development. | | 1977 | 404000 |
| effects of antihypertensive drugs on blood velocity: implications for prevention of cerebral vascular disease. | the treatment of high blood pressure prevents death from congestive heart failure, hypertensive nephropathy, and encephalopathy, and strokes from cerebral arteriolar disease (lacunes, hemorrhage from microaneurysms). however, atherosclerosis, manifested as coronary artery disease is just as frequent a cause of death in well-controlled hypertensives as in poorly-controlled patients. increasing evidence suggests that increased blood velocity, by causing turbulence and high shear rates at the endot ... | 1977 | 404009 |
| functional properties of knee ligaments and alterations induced by immobilization: a correlative biomechanical and histological study in primates. | the effect of immobility on the biomechanical properties of an anterior cruciate bone-ligament-bone unit of rhesus monkey is reported. wild primates were used and the captivity time was minimized to lessen disuse changes from cage confinement. the ligament-bone specimens were tested in tension to failure under high strain-rate conditions. after 8-weeks total-body plaster immobilization of the primate, the ligament units showed significant decreases in maximum failure load and energy absorbed to ... | 1977 | 404110 |
| bioassay of circulating luteinizing hormone in the rhesus monkey: comparison with radioimmunoassay during physiological changes. | the concentration of biologically active lh in rhesus monkey (macaca mulatta) serum was measured by a highly sensitive bioassay based upon testosterone production by dispersed rat interstitial cells. the sensitivity of the in vitro bioassay was equal to or higher than that of radioimmunoassay, with detection limits of 0.1 miu of human menopausal gonadotropin (hmg) or 10 ng of a rhesus pituitary gonadotropin preparation (ler-1909-2). parallel dose-response curves were obtained for hmg and rhesus ... | 1977 | 404130 |
| stimulus- and response-dependent units from the occipital and temporal lobes of the unanaesthetized monkey performing learnt visual tasks. | 43% of units recorded from the foveal prestriate cortex, inferotemporal cortex or amygdala of 15 rhesus monkeys performing visual discrimination or serial reversal tasks were responsive to all or some visual stimuli or other aspects of the task. six units showed activity during movements required for performance of the task. it was not possible to determine whether unit activity could be related to the learnt association of the visual stimuli with reward. | 1977 | 404174 |
| immunological sensitization following inapparent infection with dengue virus type 3 in rhesus monkeys. | rhesus monkeys previously given dengue virus type 3, without apparent viremia or antibody response, exhibited a secondary-type response upon reinoculation. these data suggest that monkeys can be immunologically sensitized to dengue virus without detectable antibody production. | 1977 | 404181 |
| vasectomy and vasovasostomy in rhesus monkeys: the effect of circulating antisperm antibodies on fertility. | rhesus monkeys develop agglutinating and complement-dependent antisperm antibodies after vasectomy. in order to study whether these antibodies affect fertility after vasovasostomy, 15 animals were given vasectomies and 6 months later vasovasostomies. subsequently, each was mated with females of proven fertility. five controls were given sham operations and similarly treated. during this period, each aimal was bled for serum to monitor the humoral immune response, ejaculated for semen analyses, a ... | 1977 | 404200 |
| differential airway reactivity to carbachol and physostigmine sulfate in rhesus monkeys with and without reagin-mediated respiratory responses. | bronchial airway reactivity to carbachol (car) and physostigmine (phy) was individually measured in three rhesus monkeys with and three rhesus monkeys without reagin-mediated respiratory responses (rr). the three monkeys with reagin-mediated rr demonstrated bronchial hyperreactivity to car (p less than 0.25) but not phy when compared with the three control monkeys. no correlation between airway reactivity to car and phy was noted in all six monkeys. we conclude that monkeys with reagin-mediated ... | 1977 | 404257 |
| experimental macular edema after lens extraction. | macular edema has been observed frequently in man after cataract extraction, but pathogenic mechanisms remain unclear. seven eyes of four young adult rhesus monkeys underwent lens extraction. the retinas and maculae of these eyes were examined by ophthalmoscopy fundus photography, fluorescein angiography, light and electron microscopy, and the horseradish peroxidase tracer technique. in the macular region, the blood-retinal barrier at the retinal vasculature was disrupted in three of the seven e ... | 1977 | 404267 |
| descending pathways from the superior collicullus: an autoradiographic analysis in the rhesus monkey (macaca mulatta). | the autoradiographic tracing method has been used to identify the various descending tectofugal pathways and their targets in the rhesus monkey (macaca mulatta). the present data reveal that the majority of descending tectofugal axons arise from collicular laminae which lie ventral to the stratum opticum (layer 3). such descending axons can be grouped into two major bundles or tracts, i.e., the ipsilateral tectopontine-tectobulbar tract and the crossed tectospinal tract (or the predorsal bundle) ... | 1977 | 404340 |
| inactivated venezuelan equine encephalomyelitis virus vaccine complexed with specific antibody: enhanced primary immune response and altered pattern of antibody class elicited. | complexes of formalinized venezuelan equine encephalomyelitis (vee) virus vaccine and specific igg formed at antigen-antibody equivalence enhanced the immune responses of rhesus monkeys (macaca mulatta). the predomonant class of antibody elicited by complexes was igg. in contrast, lower titers of antibody and a more biphasic (igg-igm) response were observed after exposure of monkeys to the vaccine alone. in comparison to the response of monkeys primed with antigen, a more rapid secondary respons ... | 1977 | 404363 |
| effects of a plasticizer leached from polyvinyl chloride on the subhuman primate: a consequence of chronic transfusion therapy. | the effects of di-2-ethylhexyl phthalate (dehp) on hepatic function and histology were evaluated in the rhesus monkey undergoing chronic transfusion. dehp was solubilized as a result of leaching by platelets or plasma stored in polyvinyl chloride (pvc) blood bags. the average cumulative amount of dehp infused in 1 year was 69.3 mg., or 21.3 mg./kg. comparable amounts of dehp are received by patients who undergo chronic transfusions with whole blood, packed cells, platelets, and plasma in the sam ... | 1977 | 404371 |
| an experimental cerebral missile injury model in primates. | an experimental model of cerebal missile injury in rhesus monkey is described. the main objective was to create a "clean" wound devoid of bleeding from major vessels and complications due to bone fragments. there was a correlation between the wounding energy and the physiological signs, although we underestimated the actual energy level. after the right parietooccipital to right frontal injury, there was bradycardia, changes in blood pressure, and, in high-energy wounds, a marked alternation in ... | 1977 | 404399 |
| the exoerythrocytic stages of plasmodium fragile in macaca mulatta monkeys. | exoerythrocytic (ee) schizonts of plasmodium fragile were found in liver tissue acquired 7, 8, 9, and 10 days following inoculation of macaca mulatta monkeys with sporozoites from anopheles balabacensis balabacensis mosquitoes. there was little to distinguish the ee bodies of p. fragile from ee bodies of many of the other species of primate malaria. | 1977 | 404416 |
| the effects of probenecid upon the individual components of indomethacin elimination. | the effects of probenecid upon plasma profiles for indomethacin and upon the individual components of total plasma clearance have been evaluated in dogs, monkeys and rats. these three species cover the wide spectrum of species differences with respect to the relative contribution of renal, biliary and metabolic clearances to elimination of indomethacin. in dogs, in which biliary clearance is the major component of elimination, probenecid raised incremental values for area under the plasma curve ... | 1977 | 404419 |
| a sequential bacteriological and serological investigation of rhesus monkeys immunised against dental caries with streptococcus mutans. | in a serial investigation of the effects of immunisation with s. mutans in rhesus monkeys maintained on a "human" type of cariogenic diet, the numbers of s. mutans in cervical plaque, crevicular-fluid washings, fissures of teeth, and in saliva were lower in immunised animals than in sham-immunised controls. immunisation also caused a delay in initial colonisation and a slowing of the rate of colonisation with s. mutans. these bacteriological changes were associated with a reduction in the smooth ... | 1977 | 404427 |
| benign ovarian teratomas in two rhesus monkeys (macaca mulatta). | | 1977 | 404466 |
| production of fetal asphyxia by maternal psychological stress. | several lines of evidence indicate that maternal psychological stress leads to adverse pregnancy outcome in rhesus monkey. chronic anxiety causes an increased stillbirth rate, fetal growth retardation, and altered placental morphology. on another time scale, lightening of maternal anesthesia during surgery produces an impaired fetal oxygenation while re-institution of anesthesia ameliorates the fetal asphyxia. the present study, for the first time, demonstrates a relationship between specific ep ... | 1977 | 404618 |
| self-administration of codeine plus acetylsalicylic acid in rhesus monkeys with unlimited access to the drugs. | the reinforcing effects of codeine (5.0 mcg/kg/infusion), acetylsalicylic acid (asa) (2500 mcg/kg/infusion) and those of combinations of codeine (50 mcg/kg/infusion) plus (2500 or 10,000 mcg/kg/infusion) were studied in four groups of drug naive rhesus monkeys. responding was engendered and maintained by infusions of 50 mcg/kg of codeine; maximal number of daily infusions being 500 to 1000. infusions of 2500 mcg/kg of asa plus 50 mcg/kg of codeine per infusion initiated responding from the 9th t ... | 1977 | 404645 |
| reinforcing properties of intravenous procaine in rhesus monkeys. | the lever pressing behavior of rhesus monkeys was maintained by a fixed ratio 10 schedule of intravenous cocaine (3 monkeys) or codeine (2 monkeys) injections during 2 hour sessions. saline or various doses of procaine hydrochloride were substituted for the baseline reinforcer for 6 consecutive sessions. each substitution was separated by 3 or more days of cocaine or codeine reinforced responding. at one or more doses, procaine substitution resulted in response rates higher than saline control i ... | 1977 | 404646 |
| effects of 19-hydroxy-prostaglandins on oviductal and uterine motility. | the effects of 19-hydroxyprostaglandins (19-oh-pgs) were tested in vivo on the rabbit oviduct and uterus and on the rhesus monkey (macaca mulatta) uterus. the 19-oh-pges suppressed spontaneous oviductal and uterine activity in the rabbit. the qualitative effect on the rabbit oviduct of 19-oh-pges was similar to that of pge2. however, the typical response of the rabbit uterus to pge2 was an increase in muscle activity. with regard to the rabbit oviduct, 19(r)-oh-pge2 was as potent as pge2, but 19 ... | 1977 | 404673 |
| spinal neurons project to the dorsal column nuclei of rhesus monkeys. | cells of origin of ascending nonprimary afferents to the dorsal column nuclei of rhesus monkeys have been identified in the spinal cord by the retrograde transport of horseradish peroxidase. these neurons are mainly located in lamina iv and medially in more ventral laminae of the dorsal horn on the side ipsilateral to the medullary injection. large neurons in the ventral horn ("spinal border cells") also appear to project to the ipsilateral dorsal medulla. the dorsal column nuclei of a primate t ... | 1977 | 404704 |
| somatosensory evoked potentials, cerebral blood flow and metabolism following cerebral missile trauma in monkeys. | somato sensory evoked potentials (sep), cerebral blood flow and cerebral metabolism were studied in seven rhesus monkeys before and after a right occipito-frontal missile injury with an air rifle. the sensory evoked potential was present shortly after injury though markedly altered in shape. there was a very close correlation (r2 equal to 0.83) between sep and cerebral blood flow on the uninjured side five minutes after injury. on the injured side, this was also noted but the amplitude of the se ... | 1977 | 404724 |
| in vitro metabolism of progestins. iii. the metabolic clearance rate of medroxyprogesterone acetate in monkeys. | 3h-medroxyprogesterone acetate (mpa) was synthesized by selective catalytic tritiation of the delta1-olefinic bond of 6alpha-methyl-17alpha-hydroxy-pregna-1,4-diene-3,20-dione acetate. the metabolic clearance rate of mpa (mcrmpa) was determined in 9 female rhesus monkeys by the single injection technique. the blood mcrmpa was 201 +/- 19 l/day (42.2 +/- 4.0 l/day/kg) which was approximately the same as that reported for progesterone clearance in the monkey. we conclude that a greater biological a ... | 1977 | 404731 |
| nystagmic responses of the rhesus monkey to rotational stimulation following unilateral labyrinthectomy: final report. | | 1977 | 404748 |
| ocular fundus of the normal rhesus monkey. (typical appearance from birth through 15 years). | | 1977 | 404750 |
| [bloodless blood pressure determination in domestic animals. i. methods, apparatus, comparative invasive measurements, cuff width and 1st measurements in rats and rhesus monkeys]. | | 1977 | 404789 |
| cyclic fluctuation in noradrenaline transmitter of the monkey oviduct. | cyclic variations in noradrenaline of the sympathetic nerves ("short adrenergic neurons") innervating the smooth musculature of the oviduct have been determined by fluorescence histochemistry and fluorometric measurements in monkeys (macaca mulatta). during the secretory phase there is more than twice as much neuronal noradrenaline in the oviduct compared with the proliferative phase. this suggests, that the system of adrenergic nerves in the primate oviduct is involved in the motility changes a ... | 1977 | 404835 |
| [effects of acetazolamide and epinephrine on aqueous flow rate in rhesus monkey (author's transl)]. | | 1977 | 404859 |
| cholecystokinin and satiety in rats and rhesus monkeys. | when ingested food does not accumulate in the stomach or enter the small intestine, rats do not stop eating. small amounts of food placed in the small intestine or intraperitoneal injections of the intestinal hormone cholecystokinin (cck) elicit the full behavioral display of satiety in these sham-feeding rats. in rhesus monkeys, intravenous infusions of cck produce large, dose-related reductions in meal size. in addition, gastric preloads of calorically trivial amounts of l-phenylalanine, but n ... | 1977 | 404865 |
| the effect of small bowel resection and subsequent precise antrectomy on lower esophageal function in rhesus monkeys. | the lower esophageal high pressure zone (hpz) was characterized manometrically and reflux status determined in eight male rhesus monkeys. the studies were repeated six weeks and six months after 50 per cent distal small bowel resection. at the same time fasting serum gastrin and gastric inhibitory polypeptide values were assayed. in seven animals precise antrectomy with gastroduodenal anastomosis was performed and the studies repeated. hpz pressure increased from 6.7 +/-0.67 mm hg (+/-1 sem) to ... | 1977 | 404930 |
| frequency of application on percutaneous absorption of hydrocortisone. | this study determines the percutaneous absorption of hydrocortisone when applied as a single dose or on a repetitive basis. application was to the shaved ventral forearm of the rhesus monkey, an animal model in which some relevance to man has been shown. absorption was quantified by measuring 14c in aliquots of urine over five days. there was no substantial difference in total absorption when 13.3 microng/sq cm was applied as a single dose or when the 13.3 microng/sq cm was applied three times, ... | 1977 | 404969 |
| [microscopic structure of the mesenteric lymph nodes of monkeys]. | the structure and cytoarchitectonics of mesenterial lymph nodes were studied in thin histological sections by different methods. under study were 5 rhesus monkeys and 3 hamadryas baboons. the square surface of different structural elements of the nodes (the cortical and medullary substances, follicles, the connective tissue framework, sinuses) occupied by them in sections was calculated and the amount of cellular elements was determined (%). comparison of the data obtained in rhesus monkeys and ... | 1977 | 404995 |
| inferior oblique myectomy, disinsertion, and recession in rhesus monkeys. | twenty-one myectomies near the insertion, 22 disinsertions, and two recessions were performed. after healing was complete, each animal was sacrificed. anatomical dissection showed the following:(1) in every disinsertion and myectomy case, the inferior oblique muscle spontaneously reattached itself to the sclera;(2) the site of reattachment following these two procedures varied widely, ranging from the original insertion site to other areas adjacent to the lateral rectus or inferior rectus insert ... | 1977 | 404997 |
| effefts of of ejaculations by males on the sexual invitations of female rhesus monkeys (macaca mulatta). | | 1977 | 405005 |
| regression of arteriosclerotic lesions in rhesus monkey aortas after regression diet. scanning and transmission electron microscope observations of the endothelium. | scanning and transmission microscopy were used to study aortic intima atherosclerotic lesions in rhesus monkeys during both progression and regression phases. scanning micrographs of severely atherosclerotic lesions showed areas of disjunctive endothelium and discontinuous basement membranes, frequently accompanied by red blood cells and other circulating elements adhering to the surface. transmission micrographs also showed occasional areas of endothelial cell damage and loss with lipid-laden s ... | 1977 | 405022 |
| luteinizing hormone secretion in the rhesus monkey and a possible role for prostaglandins. | | 1977 | 405051 |
| metabolic clearance rates, production rates and concentrations of progesterone in pregnant rhesus monkeys. | | 1977 | 405052 |
| dependence potential of drotebanol, codeine and thebaine tested in rhesus monkeys. | | 1977 | 405065 |
| an autoradiographic study of the projections of the pretectum in the rhesus monkey (macaca mulatta): evidence for sensorimotor links to the thalamus and oculomotor nuclei. | autordiographic tracing methods were used to determine the differential projections of the pretectal nuclei, in the rhesus monkey, in relation to their inputs. the sublentiform (sl) and olivary (on) nuclei receive projections from the visual cortex, superior colliculus (sc) and equal bilateral projection from the retina. the nucleus of the posterior commissure (npc) and its subdivisions do not receive any of these inputs. the projections of the pretectum involve a number of structures within the ... | 1977 | 405084 |
| a primate model for study of methotrexate pharmacokinetics in the central nervous system. | a new technique enabling repetitive sampling of cerebrospinal fluid (csf) in unanesthetized rhesus monkeys was developed to study the pharmacokinetics of methotrexate (mtx) in the csf. csf and plasma mtx levels were monitored following intraventricular and intravenous mtx administration. csf and plasma mtx disappearance curves in the monkey were virtually identical to curves generated in humans, suggesting that the mechanisms of transport between the csf and plasma compartments are similar in bo ... | 1977 | 405092 |
| association of microperoxisomes with the endoplasmic reticulum in the granulosa lutein cells of the rhesus monkey (macaca mulatta). | aldehyde fixed tissue from monkey (macaca mulatta) corpus luteum was incubated in alkaline 3,3inch-diaminobenzidine (dab), and prepared for electron microscopic histochemical observations. the association of microperoxisomes with the granular (ger) or agranular (aer) endoplasmic reticulum was reconstructed from serially sectioned tissues and by tilting of specimens in the microscope. out of 107 microperoxisomes, 106 were directly associated with the aer. two different forms of attachment were fo ... | 1977 | 405104 |
| [composite filling materials in animal experiments]. | the pulp tolerance of the composites "estic" (kulzer) and "compocap" (vivadent) and the polyacrylatecement "bondal" (vivadent) was tested in a total of 97 cervical cavities in rhesus monkeys. "bondal" was well tolerated by the pulp. both composites when used without cement base provoked slight to moderate reactions. this could be avoided by using "bondal" cement bases. | 1977 | 405192 |
| the distribution of luteinizing hormone-releasing hormone (lhrh) in the hypothalamus of the rhesus monkey. light microscopic studies using immunoperoxidase technique. | neural structures containing lhrh were characterized in the hypothalamus of the rhesus monkey by four different antisera to the hormone and an immunoperoxidase technique. immunoreactive perikarya were present in a continuum from the septal-preoptic region anteriorly to the premammillary nucleus posteriorly. these cells were more concentrated in the pericommissural and tubero-infundibular regions. reactive axons in the median eminence appeared to originate from the positive perikarya in the media ... | 1977 | 405202 |
| negative feedback control of gonadotropins in male rhesus monkeys: effects of time after castration and interactions of testosterone and estradiol-17beta. | | 1977 | 405203 |
| the stress-strain behavior of the corneoscleral envelope of the eye. ii. in vivo measurements in rhesus monkey eyes. | | 1977 | 405233 |
| androgenic control of epididymal function in rhesus monkey and rabbit. | the effects of castration and testosterone replacement therapy on the histology and biochemical composition (rna, dna, total protein, alkaline phosphatase, acid phosphatase, hyaluronidase, sialic acid, glycogen, phospholipids, and glycerylphosphorylcholine [gpc]) of the epididymis of the rabbit and rhesus monkey were investigated. castration produced marked ponderal, histologic, and biochemical changes in the epididymis. in the androgen-deficient state the tubular diameter and epithelial cell he ... | 1977 | 405258 |
| antibodies to pancreatic duct cells in sjögren's syndrome and rheumatoid arthritis. | in the present investigation the occurrence of humoral immunity to pancreatic duct cells (pdc) was studied in 12 patients with sjögren's syndrome (ss), 31 patients with rheumatoid arthritis (ra), and 64 controls. four sera of patients with ss and eight of patients with ra produced diffuse cytoplasmic fluorescence of intro- as well as of interlobular pdc of human and rhesus monkey origin. all sera positive with pdc antigens gave also positive staining reaction with parotid, submandibular, and lac ... | 1977 | 405283 |
| dihydrotestosterone propionate effects on dominance and sexual behaviors in gonadectomized male and female rhesus monkeys. | | 1977 | 405306 |
| retinal damage from long-term exposure to laser radiation. | the maculae of rhesus monkeys were exposed to an argon-ion lazer operated in the tem00 continuous wave mode at a wavelength of 514.5 nm. both ophthalmoscopic and histopathologic evaluations of exposure sites were obtained. threshold (ed50) values were obtained for 0.5, 5, 30, 120, and 1,000 sec. exposure times. presence of minimum visible lesions was assessed ophthalmoscopically at both 1 hour and 24 hours after exposure. with increasing exposure times, a 24 hr. lesion-appearance criterion resul ... | 1977 | 405344 |
| intraocular axonal swelling produced by partial, immediately retrobulbar ligature of optic nerve. | this is the first report of an experimental intraorbital ligature producing papilledema characterized by axonal swelling and accumulation of mitochondria in the lamina retinalis of the optic disc of rhesus monkeys subjected to immediately retrobulbar ligature of a portion of the optic nerve. this is an improved technique for investigating the pathogenesis of papilledema and optic neuropathy. | 1977 | 405345 |
| reverse carotid blood flow--a possible explanation for some reactions to local anesthetics. | in rhesus monkeys, data obtained by contrast radiography and hemodynamic and electroencephalographic studies indicate that carotid blood flow is reversible. results showed that even small amounts of local anesthetic agents when injected inadvertently into a branch of the external carotid artery, may enter the cerebral circulation, most likely through a retrograde flow into the common and then internal carotid arteries. some toxic neurologic manifestations possibly may be explained by this mecha ... | 1977 | 405406 |
| studies of the coagulation and complement systems during experimental rocky mountain spotted fever in rhesus monkeys. | we studied the coagulation and complement systems during rocky mountain spotted fever in macaca mulatta experimentally infected with rickettsia rickettsii. ninety-one percent of monkeys infected intravenously with a high dose (10(6) plaque-forming units [pfu]) and 56% of monkeys infected with low doses (10(-1)-10(2) pfu) of r. rickettsii died after two to four days of illness. with the onset of fever and rickettsemia, animals developed hyperfibrinogenemia, mild thrombocytopenia, prolonged prothr ... | 1977 | 405434 |
| steroids in the amniotic fluid of the rhesus monkey (macaca mulatta). | representative c21, c19 and c18 steroids have been measured in the amniotic fluid and maternal femoral plasma of rhesus monkeys during the last 50 days of pregnancy. the concentrations of cortisol, progesterone, androstenedione, oestrone sulphate all increased in amniotic fluid before spontaneous parturition. in contrast, amniotic fluid oestradiol levels remained low and unchanged, and were always less than the concentrations in the maternal plasma. the changes in progesterone, cortisol and oest ... | 1977 | 405451 |
| brain acetylcholinesterase activity and multiplicity in the bonnet monkey (macaca radiata) and the rhesus monkey (macaca mulatta). | | 1977 | 405458 |
| morphological characteristics of acetylcholinesterase-containing neurons in the cns of dfp-treated monkeys. part 2. diencephalic and medial telencephalic structures. | the distribution and morphological characteristics of neurons containing acetylcholinesterase (ache, ec 3.1.1.7.) in diencephalic and medial telencephalic structures of the rhesus monkey (macaca mulatta) were studied by means of a pharmaco-histochemical method that involves staining for ache (karnovsky-roots' procedure) at various times after the administration of di-isopropylfluorophosphate (dfp). at medial telencephalic levels, numerous, mostly multipolar, ache-containing neurons of medium to ... | 1977 | 405459 |
| investigations of the analgesic and morphine-like properties of azidomorphine. | in equianalgesic doses, azidomorphine is reported by j. knoll, s. fürst and k. kelemen (the pharmacology of azidomorphine and azidocodeine. j. pharm. pharmacol. 25: 929-939, 1973) to be less likely than morphine to cause physical dependence. as the separation of the analgesic from the dependence-producing properties would represent an important contribution to the development of potent analgesic drugs, we have compared the effects of azidomorphine and morphine in a number of experiments in labor ... | 1977 | 405472 |
| long-term behavioral changes in the rhesus monkey after multiple daily injections of d-methylamphetamine. | the effects of multiple daily injections of d-methylamphetamine on spaced lever-press responding were investigated in the rhesus monkey. responding was measured after single injections of d-mehtylamphetamine (0.0625-1.0 mg/kg) both before and after the monkeys were maintained on a multiple daily d-methylamphetamine injection regimen in doses ranging from 0.5 to 16 mg/kg/day. tolerance developed to the suppressant effects of this drug on responding. as evidenced by a shift in the dose-response cu ... | 1977 | 405473 |
| observations on trichinosis in the rhesus monkey. | monkeys infected with 2.0 larvae/g body weight died 31-41 days post-infection (pi): two of three monkeys infected with 1.0 larva/g body weight became moribund and were sacrificed at 50 days, but six of six monkeys infected with 1.0 larva/g body weight were healthy 225 days pi. periorbital and facial edema and eosinophilia were observed in all groups during the second week pi, and myalgia and stiffening of joints was observed during the third week. high numbers of encyse, biceps brachii and delto ... | 1977 | 405492 |
| cytosol and nuclear estrogen receptor in the genital tract of the rhesus monkey. | | 1977 | 405533 |
| a specific progesterone receptor of myometrial cytosol from the rhesus monkey. | a specific progesterone receptor of myometrial cytosol from the rhesus monky is described. characterization of the receptor by sucrose density gradient centrifugation revealed 2 peaks at 4s and 7.5s. the 4s peak seen in all groups (castrate; castrate plus estrogen treated; castrate plus estrogen and progesterone treated) contained little specific progesterone binding but the 7.5s peak, seen only in the estrogen-treated animal, was specific for progesterone. competition studies revealed the ... | 1977 | 405534 |