| Effects of climatic elements on Campylobacter-contaminated chicken products in Japan. | SUMMARYJapanese weather data for areas that produced Campylobacter spp.-positive chicken products were compared with those for areas producing negative samples. Regarding samples produced during the period of rising temperature (spring and summer), the mean weekly air temperatures for Campylobacter-positive samples were higher than those for negative samples for the period of the week in which the samples were purchased (18·7°C vs. 13·1°C, P=0·006) to a 12-week lag (12 weeks before purchasing sa ... | 2011 | 21906416 |
| dynamic proteome changes in campylobacter jejuni 81-176 after high pressure shock and subsequent recovery. | campylobacter jejuni is one of the most intriguing human foodborne bacterial pathogen. its survival throughout the food processing chain and its pathogenesis mechanisms in humans remain enigmatic. living in the animal guts and particularly in avian intestine as a commensal bacterium, this microorganism is frequently isolated from meat products. ultra high pressure (hp) is a promising alternative to thermal technology for microbial safety of foodstuffs with less organoleptic and nutritional alter ... | 2011 | 22079248 |
| Prevalence of Campylobacter and Salmonella in raw chicken on retail sale in the republic of Ireland. | To assess the current risks to consumers from Campylobacter and Salmonella in raw chicken products sold in the Republic of Ireland, a retail survey was undertaken to define their prevalence. Samples (n = 510) were analyzed using protocols based on ISO 10272-1:2006 and ISO 6579:2002. Processor codes on pack labels showed that 67% of samples were produced in the Republic of Ireland and 25% in the United Kingdom. Salmonella was present in 5.1% of samples, but the eight serovars found caused less t ... | 2011 | 22054193 |
| survival of campylobacter jejuni in co-culture with acanthamoeba castellanii: role of amoeba-mediated depletion of dissolved oxygen. | campylobacter jejuni is a major cause of infectious diarrhoea worldwide but relatively little is known about its ecology. in this study, we examined its interactions with acanthamoeba castellanii, a protozoan suspected to serve as a reservoir for bacterial pathogens. we observed rapid degradation of intracellular c. jejuni in a. castellanii 5 h post gentamicin treatment at 25°c. conversely, we found that a. castellanii promoted the extracellular growth of c. jejuni in co-cultures at 37°c in aero ... | 2011 | 22176643 |
| Prospective study to validate HpOne in the diagnosis of Helicobacter pylori infection. | Introduction: The HpOne test is a new five-minute rapid urease test developed for the rapid detection of Helicobacter pylori infection during gastroscopy. However, evidence in the literature supporting its use clinically is scarce. The most commonly used rapid urease test remains the Campylobacter-like organism (CLO) test, which generates accurate readings only after 24 hours. The aim of this study was to evaluate the efficacy of the HpOne test in our local population. Methods: From August 20 ... | 2011 | 22173251 |
| Survival of host-associated Bacteroidales cells and their relationship with Enterococcus spp., Campylobacter jejuni, Salmonella Typhimurium and Adenovirus in freshwater microcosms as measured by PMA-qPCR. | The ideal host-associated genetic fecal marker would be capable of predicting the presence of specific pathogens of concern. Flow-through freshwater microcosms containing mixed feces and inocula of the pathogens Campylobacter jejuni, Salmonella Typhimurium and Adenovirus were placed at ambient temperature in the presence and absence of diurnal sunlight. The total Enterococcus DNA increased during the early periods (23 h) under sunlight exposure, even though cultivable Enterococcus and DNA in int ... | 2011 | 22139002 |
| A Campylobacter jejuni Dps Homolog Has a Role in Intracellular Survival and in the Development of Campylobacterosis in Neonate Piglets. | Abstract Iron acquisition is an absolute requirement by most microorganisms for host survival. In this work, we investigated the Campylobacter jejuni iron binding Dps protein for a potential role in virulence. In vitro assays using J774A.1 macrophage-like cells demonstrated a 2.5 log reduction in C. jejuni survival of the Dps mutant and a reduction of four logs in invasion of HEp-2 epithelial cells compared to the wild-type strain. To examine the role of the dps gene in host pathogenesis, the ... | 2011 | 21854265 |
| The twin-arginine translocation system: contributions to the pathobiology of Campylobacter jejuni. | The twin-arginine translocation (Tat) system is specialized in the transport of folded proteins across the cytoplasmic membrane. Although the mechanisms that govern the Tat transport and its scope are not well understood, this system and its cognate substrates are involved in important functions that facilitate the adaptation and survival of bacteria. Evidence also exists that connects the Tat system to virulent traits of clinically relevant pathogens. Of interest is Campylobacter jejuni, an imp ... | 2011 | 22082291 |
| microbiological quality of freshly shot game in germany. | in the framework of a project on the hygiene status of freshly shot game 289 samples were microbiologically analysed: 127 samples from wild boars, 95 from roe deer and 67 from red deer. the microbiological parameters evaluated were the mesophilic aerobic count (apc), which showed mean log10-counts of 2.6cfu/cm(2) for roe deer, 2.9cfu/cm(2) for red deer and 3.2cfu/cm(2) for wild boars and the numbers of enterobacteriaceae, which gave mean log10-values of 2.1cfu/cm(2) for all three species with di ... | 2008 | 22062460 |
| Fisher syndrome: clinical features, immunopathogenesis and management. | Since Miller Fisher's first report in 1956, evidence has accumulated about clinical and laboratory features, immunopathogenesis and treatment of Fisher syndrome (FS). Our literature review revealed the nature of FS. It has relatively uniform clinical and laboratory features. Ophthalmoplegia, ataxia and areflexia are essential prerequisites for an FS diagnosis, but there are several clinical variants with isolated ophthalmoplegia or ataxia. The discovery of serum anti-GQ1b antibody in FS has led ... | 2012 | 22149656 |
| Genes coding for virulence determinants of Campylobacter jejuni in human clinical and cattle isolates from Alberta, Canada, and their potential role in colonization of poultry. | Forty nine Campylobacter jejuni isolates from cattle feces collected from Alberta feedlots and 50 clinical C. jejuni isolates from people in Alberta were tested for the presence of 14 genes encoding putative virulence factors by PCR. These included genes implicated in adherence and colonization (flaC, cadF, docC, racR, jlpA, peb1, and dnaJ), invasion (virB11, ciaB, pldA, and iamA) and protection against harsh conditions (htrA, cbrA, and sodB). The genes examined were widely distributed in both t ... | 2011 | 22015699 |
| the campylobacter jejuni nctc11168 capsule prevents excessive cytokine production by dendritic cells. | campylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide, mainly caused by handling and consumption of contaminated poultry. however, the immune response to infection is poorly understood. here, the impact of the c. jejuni capsule, flagella and the n-linked glycosylation system on cytokine production by dendritic cells was investigated. bone marrow-derived murine dendritic cells (bmdcs) infected with c. jejuni lacking the n-linked glycosylation system produced simil ... | 2011 | 21863342 |
| htra chaperone activity contributes to host cell binding in campylobacter jejuni. | abstract: | 2011 | 21939552 |
| [Investigation of verotoxigenic escherichia coli O157:H7 incidence in gastroenteritis patients]. | Escherichia coli O157:H7 is the most common serotype among verotoxigenic E.coli (VTEC) strains that cause haemolytic uremic syndrome. Although sporadic VTEC cases originating from Turkey and small outbreaks have been reported from our country, VTEC has not been routinely investigated in most of the diagnostic microbiology laboratories in Turkey and studies related to this topic are limited. In this study, the incidence of E.coli O157:H7 in patients who were admitted to Alanya Research and Applic ... | 2011 | 21935785 |
| Genotypic and phenotypic properties of cattle-associated Campylobacter and their implications to public health in the USA. | Since cattle are a major source of food and the cattle industry engages people from farms to processing plants and meat markets, it is conceivable that beef-products contaminated with Campylobacter spp. would pose a significant public health concern. To better understand the epidemiology of cattle-associated Campylobacter spp. in the USA, we characterized the prevalence, genotypic and phenotypic properties of these pathogens. Campylobacter were detected in 181 (19.2%) out of 944 fecal samples. S ... | 2011 | 22046247 |
| seasonal variation in campylobacter-contaminated retail chicken products: a year-round investigation in japan. | campylobacter was isolated from retail meat samples collected during the fiscal year 2009 in japan. the higher percentages of contamination of chicken products were observed from june (39.3%) to november (83.3%). however, the highest number of human campylobacteriosis cases was reported in june in the infectious agents surveillance report. the chicken isolates with distinct clusters ivb and i, based on the restriction fragment length polymorphism of the flaa gene, were predominantly obtained dur ... | 2011 | 21878745 |
| phenotypic and genotypic methods for typing campylobacter jejuni and campylobacter coli in poultry. | human campylobacteriosis, an infection caused by the bacterium campylobacter, is a major issue in the united states food system, especially for poultry products. according to the center for disease control, campylobacterosis is estimated to affect over 2.4 million people annually. campylobacter jejuni and campylobacter coli are 2 species responsible for the majority of campylobacterosis infections. phenotypic and genotypic typing methods are often used to discriminate between bacteria at the spe ... | 2012 | 22184452 |
| Detection of diarrhoeal pathogens in human faeces using an automated, robotic platform. | Infectious diarrhoeal diseases represent a major socio-economic burden to humans, and are linked to a range of pathogens, including viruses, bacteria and protists. The accurate detection of such pathogens is central to control. However, detection often relies on methods that have limited diagnostic sensitivity and specificity. Here, we assessed an automated, robotic platform for the simultaneous detection of eight major pathogens associated with infectious diarrhoea. Genomic DNA samples (n = 167 ... | 2011 | 22056326 |
| Early microbial succession in redeveloping dental biofilms in periodontal health and disease. | Teles FR, Teles RP, Uzel NG, Song XQ, Torresyap G, Socransky SS, Haffajee AD. Early microbial succession in redeveloping dental biofilms in periodontal health and disease. J Periodont Res 2011; doi: 10.1111/j.1600-0765.2011.01409.x. © 2011 John Wiley & Sons A/S Background and Objective: The development of dental biofilms after professional plaque removal is very rapid. However, it is not clear whether most bacterial species return at similar rates in periodontally healthy and periodontitis subj ... | 2011 | 21895662 |
| cellular response of campylobacter jejuni to trisodium phosphate. | the highly alkaline compound trisodium phosphate (tsp) is used as an intervention to reduce the load of campylobacter on poultry meat in u.s. poultry slaughter plants. the aim of the present study was to investigate the cellular responses of campylobacter jejuni nctc11168 when exposed to sub-lethal concentrations of tsp. pre-exposure of c. jejuni to tsp resulted in a significant increase in heat sensitivity, suggesting that a combined heat and tsp treatment may increase reduction of c. jejuni. a ... | 2011 | 22194296 |
| postcards from the edge? | | 2011 | 21877394 |
| Development of a rapid and sensitive method combining a cellulose ester microfilter and a real-time qPCR assay to detect Campylobacter jejuni and Campylobacter coli in 20 liters of drinking water or low turbidity waters. | Investigation of Campylobacter jejuni and Campylobacter coli in samples of drinking water suspected of being at the origin of outbreak very often leads to negative results. One of the reasons for this failure is the small volume of water typically used for detecting these pathogens (10 to 1000 mL). Efficiency of three microfilters and different elution procedures were determined using real-time qPCR to propose a procedure allowing detection of Campylobacter in 20 L drinking water or low turbidit ... | 2011 | 22138985 |
| occurrence of escherichia coli o157:h7, listeria monocytogenes, salmonella and campylobacter spp. on beef carcasses in northern ireland. | a survey of beef carcasses was conducted in all 10 european community approved abattoirs in northern ireland to determine the incidence of escherichia coli o157:h7. analyses were based on excised samples of neck meat taken less than 48 h post-kill. overall, 780 carcasses were sampled and all were negative for e. coli o157:h7. a sub-set of samples was analysed for the presence of listeria monocytogenes (n=200), salmonella (n=200) and campylobacter spp.(n=100). l. monocytogenes was not detected bu ... | 2001 | 22062423 |
| finnish campylobacter jejuni strains of multilocus sequence type st-22 complex have two lineages with different characteristics. | campylobacter jejuni is the major cause of human bacterial gastroenteritis worldwide, and in a minority of cases, post-infectious complications may occur. st-22 complex (usually penner serotype 19) strains have been overrepresented among patients with postinfectious complications of campylobacteriosis. we here present a characterization of a collection of 27 finnish c. jejuni strains of st-22 complex, from humans (22 strains) and animal sources (five strains), with the aim of contributing to our ... | 2011 | 22039552 |
| Simultaneous Detection of Six Diarrhea-Causing Bacterial Pathogens with an In-House PCR-Luminex Assay. | Diarrhea can be caused by a range of pathogens, including several bacteria. Conventional diagnostic methods, such as culture, biochemical tests, and enzyme-linked immunosorbent assay (ELISA), are laborious. We developed a 7-plex PCR-Luminex assay to simultaneously screen for several of the major diarrhea-causing bacteria directly in fecal specimens, including pathogenic Aeromonas, Campylobacter jejuni, Campylobacter coli, Salmonella, Shigella, enteroinvasive Escherichia coli (EIEC), Vibrio, and ... | 2012 | 22075596 |
| Exploiting bacterial glycosylation machineries for the synthesis of a Lewis antigen-containing glycoprotein. | Glycoproteins constitute a class of compounds of increasing importance for pharmaceutical applications. The manipulation of bacterial protein glycosylation systems from Gram-negative bacteria for the synthesis of recombinant glycoproteins is a promising alternative to the current production methods. Proteins carrying Lewis antigens have been shown to have potential applications for the treatment of diverse autoimmune diseases. In this work, we developed a mixed approach consisting of in vivo and ... | 2011 | 21878645 |
| Enteropathogens in acute diarrhea: a general practice-based study in a Nordic country. | The epidemiology of infectious diarrhea influences the microbiological investigation of the disease, and is best elucidated through prospective studies. We undertook such a study in a Nordic country. Patients of all age groups who had acute diarrhea were recruited prospectively from general practice clinics in Iceland. They completed a questionnaire and provided stool samples for the detection of pathogenic viruses, bacteria, and parasites. Of the 464 recruited patients, 211 (45%) had 224 infect ... | 2011 | 22057365 |
| Modelling transfer of Salmonella Typhimurium DT104 during simulation of grinding of pork. | Aims: The aim of this study was to develop a model to predict cross-contamination of Salmonella during grinding of pork. Methods and Results: Transfer rates of Salmonella were measured in three experiments, where between 10 and 20 kg meat was ground into 200-g portions. In each experiment, five pork slices of about 200 g per slice were inoculated with 8-9 log-units of Salmonella Typhimurium DT104 and used for building up the contamination in the grinder. Subsequently, Salmonella-free slices we ... | 2012 | 22008626 |
| Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011. | To establish strategic priorities for the German national public health institute (RKI) and guide the institute's mid-term strategic decisions, we prioritized infectious pathogens in accordance with their importance for national surveillance and epidemiological research. | 2011 | 21991334 |
| pan-european monitoring of susceptibility to human-use antimicrobial agents in enteric bacteria isolated from healthy food-producing animals. | objectives: to determine the antimicrobial susceptibility of escherichia coli, salmonella, campylobacter and enterococcus from cattle, pigs and chickens across the european union (eu) using uniform methodology. methods: intestinal samples (1624) were taken at slaughter across five eu countries. bacteria were isolated in national laboratories, whilst mics were determined in a central laboratory for key antimicrobials used in human medicine. clinical resistance was based on clsi breakpoints and de ... | 2011 | 22210758 |
| Postinfectious irritable bowel syndrome: follow-up of a patient cohort of confirmed cases of bacterial infection with Salmonella or Campylobacter. | Gastrointestinal infections have been proposed to predict subsequent irritable bowel syndrome (IBS) but large-scale infectious events are rare and long-term data are missing. | 2011 | 21883703 |
| in vivo and in silico determination of essential genes of campylobacter jejuni. | in the united kingdom, the thermophilic campylobacter species c. jejuni and c. coli are the most frequent causes of food-borne gastroenteritis in humans. while campylobacteriosis is usually a relatively mild infection, it has a significant public health and economic impact, and possible complications include reactive arthritis and the autoimmune diseases guillain-barré syndrome. the rapid developments in "omics" technologies have resulted in the availability of diverse datasets allowing predicti ... | 2011 | 22044676 |
| Prevalence and antimicrobial susceptibility of major foodborne pathogens in imported seafood. | Seafood is a leading commodity implicated in foodborne disease outbreaks in the United States. Seafood importation rose dramatically in the past 3 decades and now contributes to more than 80% of the total U.S. seafood supply. However, limited data are available on the microbiological safety of imported seafood. In this study, we obtained a total of 171 salmon, shrimp, and tilapia samples imported from 12 countries in three retail stores in Baton Rouge, LA. The total microbial population and the ... | 2011 | 21902913 |
| microbial safety of meat in the european union. | the two most frequently reported zoonotic diseases in humans in the eu in 2005 were campylobacter and salmonella infections with incidences of 51.6 and 38.2 cases per 100,000 population, respectively. reported human infections caused by yersinia spp., verocytotoxigenic escherichia coli, and listeria monocytogenes had comparably lower incidences of 2.6, 1.2 and 0.3 cases per 100,000 population, respectively. meat and meat products are important sources for these infections but knowledge on exactl ... | 2008 | 22062091 |
| Spatial Distribution of Putative Growth Factors in the Guinea Pig Placenta and the Effects of These Factors, Plasma, and Bile on the Growth and Chemotaxis of Campylobacter jejuni. | The pregnant guinea pig is an effective model for studying abortifacient Campylobacter spp, and previous experiments have demonstrated that C. jejuni IA3902 has a marked predilection for the subplacenta while sparing the placental disc in this species. In the study described here, the growth and chemotaxis of IA3902 and a reference strain (NCTC 11168) are compared in the presence of subplacental and placental factors, as well as bile and plasma, from pregnant and nonpregnant guinea pigs. Both st ... | 2011 | 22081135 |
| fecal indicators and zoonotic pathogens in household drinking water taps fed from rainwater tanks in southeast queensland, australia. | in this study, the microbiological quality of household tap water samples fed from rainwater tanks was assessed by monitoring the numbers of escherichia coli bacteria and enterococci from 24 households in southeast queensland (seq), australia. quantitative pcr (qpcr) was also used for the quantitative detection of zoonotic pathogens in water samples from rainwater tanks and connected household taps. the numbers of zoonotic pathogens were also estimated in fecal samples from possums and various s ... | 2012 | 22020514 |
| development of a loop-mediated isothermal amplification assay for rapid, sensitive and specific detection of a campylobacter jejuni clone. | loop-mediated isothermal amplification (lamp) assay is a simple, rapid and specific detection method and has been used for detection and identification of different campylobacter species. in this study, we develop a lamp assay specific for detection of a particular clone (clone sa) of campylobacter jejuni, associated with the vast majority of recent sheep abortions in the u.s. using a set of specific primers for c. jejuni ia3902 (a clone sa isolate) and genomic dna or boiled cell extract as temp ... | 2011 | 22188995 |
| Lack of correlation between the 257C-to-T mutation in the gyrA gene and clinical severity of Campylobacter jejuni infection in a region of high incidence of ciprofloxacin resistance. | Fluoroquinolone resistance is increasingly detected in Campylobacter jejuni worldwide. Despite the fact that a point mutation in the gyrA gene has been linked with increased fitness in animals, the association of resistant organisms with more severe infections in man remains controversial. | 2011 | 21905953 |
| a tolerogenic mucosal immune response leads to persistent campylobacter jejuni colonization in the chicken gut. | campylobacter enteritis is the most reported zoonotic disease in many developed countries where it imposes a serious health burden. campylobacter transmission to humans occurs primarily through the chicken vector. chicks are regarded as a natural host for campylobacter species and are colonized with c. jejuni in particular. but despite carrying a very high bacterial load in their gastrointestinal tract, these birds, in contrast to humans, do not develop pathological signs. it seems that in chick ... | 2011 | 21995731 |
| interruption of microbial cycles in farm animals from farm to table. | the fact that only slight problems are posed by salmonella, campylobacter and escherichia coli o157 in mammalian farm animals in norway, is undoubtedly due in large degree to the agricultural set-up with small farms and small herds, allowing a good overview of the situation at any time. other factors are the very limited import of breeding animals and food products of animal origin, microbiological control of animal feed, and favourable geographical and climatic conditions. however, the norwegia ... | 1996 | 22060640 |
| impaired fitness and transmission of macrolide-resistant campylobacter jejuni in its natural host. | campylobacter jejuni is a major zoonotic pathogen transmitted to humans via the food chain and is prevalent in chickens, a natural reservoir for this pathogenic organism. due to the importance of macrolide antibiotics in clinical therapy of human campylobacteriosis, development of macrolide resistance in campylobacter has become a concern for public health. to facilitate the control of macrolide-resistant campylobacter, it is necessary to understand if macrolide resistance affects the fitness an ... | 2011 | 22183170 |
| luxs distribution and ai-2 activity of campylobacter spp. | aims: this study investigates the distribution of luxs within campylobacter (camp.) species and autoinducer (ai)-2 activity of camp. jejuni nctc 11168 in food matrices. methods and results: luxs (s-ribosylhomocysteinase) sequences of different campylobacter spp. were compared, and ai-2 activity was measured with an ai-2 reporter assay. highest luxs homologies were shared by camp. jejuni, camp. coli and camp. upsaliensis, and their luxs sequences had more similarities to the analysed arcobacter ... | 2011 | 22188245 |
| crystallization and preliminary crystallographic studies of campylobacter jejuni chuz, a member of a novel haem oxygenase family. | the haem oxygenase chuz from campylobacter jejuni, a major enteric pathogen in humans, is part of the iron-acquisition mechanism that is involved in bacterial survival and persistence in hosts. the chuz-haemin complex has been purified and crystallized and diffraction data have been collected to 2.4 å resolution. the chuz-haemin complex crystals belonged to space group c222(1), with unit-cell parameters a = 106.474, b = 106.698, c = 52.464 å, α = β = γ = 90°. the asymmetric unit contained one ch ... | 2011 | 22102034 |
| Genome and proteome of Campylobacter jejuni bacteriophage NCTC 12673. | Campylobacter jejuni continues to be the leading cause of bacterial food-borne illness worldwide, so improvements to current methods used for bacterial detection and disease prevention are needed. We describe here the genome and proteome of C. jejuni bacteriophage NCTC 12673 and the exploitation of its receptor-binding protein for specific bacterial detection. Remarkably, the 135-kb Myoviridae genome of NCTC 12673 differs greatly from any other proteobacterial phage genome described (including C ... | 2011 | 21965409 |
| potentially pathogenic bacteria and antimicrobial resistance in bioaerosols from cage-housed and floor-housed poultry operations. | background: antibiotics are used in animal confinement buildings, such as cage-housed (ch) and floor-housed (fh) poultry operations, to lower the likeliness of disease transmission. in fh facilities, antibiotics may also be used at sub-therapeutic levels for growth promotion. low levels of antibiotic create a selective pressure toward antimicrobial resistance (amr) in chicken fecal bacteria. objective: the objective of this study was to compare bacteria and amr genes in bioaerosols from ch and ... | 2011 | 22156572 |
| molecular epidemiology of campylobacter isolates from poultry production units in southern ireland. | this study aimed to identify the sources and routes of transmission of campylobacter in intensively reared poultry farms in the republic of ireland. breeder flocks and their corresponding broilers housed in three growing facilities were screened for the presence of campylobacter species from november 2006 through september 2007. all breeder flocks tested positive for campylobacter species (with c. jejuni and c. coli being identified). similarly, all broiler flocks also tested positive for campyl ... | 2011 | 22163024 |
| the spatial and temporal determinants of campylobacteriosis notifications in new zealand, 2001-2007. | summarydespite recent improvements, new zealand still has one of the highest per-capita incidence rates of campylobacteriosis in the world. to reduce the incidence, a thorough understanding of the epidemiology of infection is needed. this retrospective analysis of 36 000 notified human cases during a high-risk period between 2001 and 2007 explored the spatial and temporal determinants of campylobacter notifications at a fine spatial scale in order to improve understanding of the complex epidemio ... | 2011 | 22050713 |
| Thermofluor-based optimization strategy for the stabilization and crystallization of Campylobacter jejuni desulforubrerythrin. | Desulforubrerythrin from Campylobacter jejuni has recently been biochemical and spectroscopically characterized. It is a member of the rubrerythrin family, and it is composed of three structural domains: the N-terminal desulforedoxin domain with a non-heme iron center, followed by a four-helix bundle domain harboring a binuclear iron center and finally a C-terminal rubredoxin domain. To date, this is the first example of a protein presenting this kind of structural domain organization, and there ... | 2012 | 22051151 |
| development and evaluation of cmec subunit vaccine against campylobacter jejuni. | campylobacter jejuni is the leading bacterial cause of human enteritis in many industrialized countries. there is no commercial vaccine against c. jejuni available to date. cmec is an essential outer membrane component of cmeabc multidrug efflux pump that plays a critical role in antibiotic resistance and in vivo colonization of c. jejuni. cmec is prevalent in c. jejuni strains and is dramatically induced and immunogenic in vivo. in this study, we analyzed cmec sequence homology, examined in vit ... | 2010 | 22140651 |
| high voltage electrical stimulation: its effect on microbial contamination of lamb carcases in a commercial abattoir. | this study was designed to establish the effect of an abattoir's commercial high voltage electrical stimulator on lamb carcase microbial contamination, including tvc, coliform and campylobacter colony counts. over eight visits, batches of six lamb carcases were sampled using the wet and dry swab technique both before and after passage through a high voltage electrical stimulator. on each visit three of the carcases were sent through the electrical stimulator while it was operational (the treatme ... | 1999 | 22062701 |
| bacteriophage f336 recognizes the capsular phosphoramidate modification of campylobacter jejuni nctc11168. | bacteriophages infecting the food-borne human pathogen campylobacter jejuni could potentially be exploited to reduce bacterial counts in poultry prior to slaughter. this bacterium colonizes the intestinal tract of poultry in high numbers, and contaminated poultry meat is regarded as the major source of human campylobacteriosis. in this study, we used phage f336 belonging to the myoviridae family to select a c. jejuni nctc11168 phage-resistant strain, called 11168r, with the aim of investigating ... | 2011 | 21965558 |
| Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea. | To explore the value of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea. | 2011 | 22072854 |
| Occurrence of fastidious Campylobacter spp. in fresh meat and poultry using an adapted cultural protocol. | This study used an adapted cultural protocol for the recovery of fastidious species of Campylobacter, to gain a more accurate understanding of the diversity of Campylobacter populations in fresh meats. Chicken (n=185), pork (n=179) and beef (n=186) were collected from supermarkets and butchers throughout the Republic of Ireland. Samples were enriched in Campylobacter enrichment broth for 24h under an atmosphere of 2.5% O(2), 7% H(2), 10% CO(2), and 80.5% N(2). The enriched samples were then filt ... | 2011 | 21855156 |
| Polar Flagellar Biosynthesis and a Regulator of Flagellar Number Influence Spatial Parameters of Cell Division in Campylobacter jejuni. | Spatial and numerical regulation of flagellar biosynthesis results in different flagellation patterns specific for each bacterial species. Campylobacter jejuni produces amphitrichous (bipolar) flagella to result in a single flagellum at both poles. These flagella confer swimming motility and a distinctive darting motility necessary for infection of humans to cause diarrheal disease and animals to promote commensalism. In addition to flagellation, symmetrical cell division is spatially regulated ... | 2011 | 22144902 |
| [Campylobacteriosis in Poland in 2009]. | The total number of 360 campylabacteriosis cases were reported in 2008 in Poland. The incidence rate was 0.94 per 100 000 population. All reported cases met criteria of confirmed case of EU case definition. No death was reported. More than 58% of patients were hospitalized. The species of Campylobacter was determined in 283 cases (78,6%): 225 cases (62,5%) were caused by C. jejuni, 47 (about 13%) by C. coli and 11 (about 3%) by C. upsalenssis. Four family outbreaks were reported in 2009 in Polan ... | 2011 | 21913467 |
| the physiologic and phenotypic alterations due to macrolide exposure in campylobacter jejuni. | physiologic and phenotypic alterations in the context of antibiotic resistance have been extensively studied in some bacteria. however there are not enough data addressing these alterations due to macrolide resistance in campylobacter jejuni. the present study examined the fitness cost imposed by different macrolide resistance mutations and the phenotypic alterations due to exposure to macrolides in c. jejuni. c. jejuni was induced with different macrolide agents to obtain different macrolide re ... | 2011 | 21875757 |
| [infectious enteritis]. | infectious diarrhea belongs to the most frequent infections worldwide and can be elicited by a wide array of microbial pathogens. in developed countries transmission occurs much more frequently from contaminated food as compared to direct person-to-person contact, except for enteric viruses which can also be transmitted by aerosol formation after vomiting. in germany, more than 90% of cases are caused by the four pathogens norovirus, rotavirus, campylobacter and salmonella. therapy of infectious ... | 2011 | 21847579 |
| microbiological ecology of marinated meat products. | marinated meat products are consumed increasingly. in addition to taste, marinating has been considered to increase product safety and shelf life. in finland, marinades are complex, spiced sauces. they are acidic water-oil emulsions typically containing salt, sugar, sorbate and/or benzoate. marinated products are usually packaged under modified atmospheres. this results in the growth of psychrotrophic, anaerobic bacteria like lactic acid bacteria (lab). marinating did not increase the shelf life ... | 2005 | 22063746 |
| Market surveillance for contamination with thermotolerant campylobacters on various categories of chicken meat in Switzerland. | From April 2009 to April 2010, 1,132 samples of different types of chicken meat were tested qualitatively and quantitatively for thermotolerant campylobacters. Samples were recovered at retail in shops from the entire territory of Switzerland and comprised imported meat and meat from domestic production. The meat categories covered by the study were refrigerated and frozen meat, meat with and without skin, and meat preparations. Overall, 38.4% of the samples were positive, and in 27.8%, Campylo ... | 2011 | 22186044 |
| International Committee on Systematics of Prokaryotes. Subcommittee on the taxonomy of Campylobacter and related bacteria: Minutes of the closed Meeting, 2 September 2009, Niigata, Japan. | | 2011 | 21976590 |
| antimicrobial susceptibility testing of german campylobacter fetus subsp. venerealis isolates by agar disk diffusion method. | campylobacter fetus subsp. venerealis is the causative agent of bovine genital campylobacteriosis and is transmitted by asymptomatic carrier bulls via contaminated semen during artificial insemination. the aim of the present study was to determine the in vitro susceptibility of campylobacter fetus subsp. venerealis isolated from bovine specimens in the years from 2000 to 2009 in germany to antibiotics generally used in semen treatment. the susceptibilities of 50 strains to spectinomycin (10 micr ... | 2011 | 22059289 |
| Rotavirus in adults requiring hospitalization. | To determine the prevalence and epidemiological characteristics of rotavirus among adults admitted to the hospital with diarrhea that have bacterial stool cultures sent. | 2012 | 21939687 |
| a survey of salmonella spp and campylobacter spp in dairy goat faeces and bulk tank milk in the murcia region of spain. | this study was designed to investigate the occurrence of salmonella spp and campylobacter spp in faeces samples from 222 healthy murciano-granadina dairy goats reared on 12 farms in spain and in samples of bulk tank milk from 11 of those herds. neither salmonella spp nor campylobacter spp were isolated from any of the samples. our results suggest that, under the management practices applied to this breed in spain, murciano-granadina goats are not likely to be a significant reservoir for these fo ... | 2006 | 21851684 |
| emerging dynamics of human campylobacteriosis in southern ireland. | infections with campylobacter spp. pose a significant health burden worldwide. the significance of campylobacter jejuni/campylobacter coli infection is well appreciated but the contribution of non-c. jejuni/c. coli spp. to human gastroenteritis is largely unknown. in this study, we employed a two-tiered molecular study on 7194 patient faecal samples received by the microbiology department in cork university hospital during 2009. the first step, using entericbio(®) (serosep), a multiplex pcr syst ... | 2011 | 22077228 |
| Development of a set of multiplex standard polymerase chain reaction assays for the identification of infectious agents from aborted bovine clinical samples. | The current study describes the development of a set of 5 multiplex polymerase chain reaction (mPCR) assays for the simultaneous detection of abortive infection agents in bovine fetal tissues, including Brucella spp., Leptospira spp., and Campylobacter fetus (mPCR1); Hammondia heydorni, Neospora caninum, and Toxoplasma gondii (mPCR2); Coxiella burnetii and Chlamydophila psittaci (mPCR3); Mycoplasma bovis, Mycoplasma bovigenitalium, and Ureaplasma diversum (mPCR4); and Bovine viral diarrhea virus ... | 2011 | 21908306 |
| qmraspot: a tool for quantitative microbial risk assessment from surface water to potable water. | in the netherlands, a health based target for microbially safe drinking water is set at less than one infection per 10,000 persons per year. for the assessment of the microbial safety of drinking water, dutch drinking water suppliers must conduct a quantitative microbial risk assessment (qmra) at least every three years for the so-called index pathogens enterovirus, campylobacter, cryptosporidium and giardia. in order to collect raw data in the proper format and to automate the process of qmra, ... | 2011 | 21885080 |
| campylobacter populations in wild and domesticated mallard ducks (anas platyrhynchos). | identifying the campylobacter genotypes that colonize farmed and wild ducks will help to assess the proportion of human disease that is potentially attributable to the consumption of duck meat and environmental exposure to duck faeces. comparison of temporally and geographically matched farmed and wild ducks showed that they had different campylobacter populations in terms of: (i) prevalence, (ii) campylobacter species and (iii) diversity of genotypes. furthermore, 92.4% of campylobacter isolate ... | 2011 | 22164198 |
| quantification of campylobacter and salmonella in cattle before, during, and after the slaughter process. | salmonella and campylobacter cause a significant number of human illnesses globally, most of which are food related. cattle can be asymptomatic carriers of both of these pathogens. the objective of this study was to determine the association between the concentration of salmonella and campylobacter pre- and postharvest in cattle. samples were collected from each of 98 individually identified cattle during the periharvest and postharvest period. for each animal, four different phases were sampled ... | 2011 | 22044244 |
| acute transverse myelitis as a rare manifestation of campylobacter diarrhoea with concomitant disruption of the blood brain barrier. | we describe a case of acute transverse myelitis following campylobacter diarrhoea in an adult. the patient presented with diplegia due to a longitudinal spinal cord lesion. the csf demonstrated an aseptic meningitis. oligoclonal bands and c. jejuni-specific igg were detected in serum and cerebrospinal fluid at the beginning of the neurological illness. the patient was treated with antimicrobial therapy and steroids. a near full recovery was made and there were no relapses. c. jejuni is strongly ... | 2011 | 22133816 |
| [antimicrobial sensitivity of hippurate-negative campylobacter and helicobacter pullorum strains isolated from patients with diarrhea]. | c. jejuni as well as some hippurate-negative campylobacter species and related diarrheagenic organisms, are the leading cause of gastroenteritis in our environment all throughout the year. the aim of the present study was to determine the sensitivity of hippurate-negative campylobacter and helicobacter pullorum strains isolated from the stools of patients with diarrhea. we tested 39 campylobacter coli, two c. lari and five helicobacter pullorum strains identified by mass spectrometry analysis. t ... | 2011 | 22173192 |
| The Prevalence of Campylobacter amongst a Free-Range Broiler Breeder Flock Was Primarily Affected by Flock Age. | Campylobacter successfully colonizes broiler chickens, but little is known about the longer term natural history of colonization, since most flocks are slaughtered at an immature age. In this study, the prevalence and genetic diversity of Campylobacter colonizing a single free-range broiler breeder flock was investigated over the course of a year. The age of the flock was the most important factor in determining both the prevalence and diversity of Campylobacter over time. There was no correlati ... | 2011 | 22174732 |
| Utilizing a combination of molecular and spatial tools to assess the effect of a public health intervention. | Until recently New Zealand had one of the highest rates of human campylobacteriosis reported by industrialized countries. Since the introduction of a range of control measures in the poultry production chain a reduction in human cases of around 50% has been observed nationwide. To inform risk managers a combination of spatial, temporal and molecular tools - including minimum spanning trees, risk surfaces, rarefaction analysis and dynamic source attribution modelling - was used in this study to f ... | 2011 | 21872952 |
| [fatal bacteremia caused by campylobacter fetus and campylobacter jejuni in patients with alcoholic liver disease]. | | 2011 | 21947101 |
| campylobacter fetus bacteremia in a young healthy adult transmitted by khat chewing. | campylobacter fetus is a pathogen affecting almost exclusively patients with immunosuppression and chronic debilitating diseases. we report the case of a healthy young man with c. fetus bacteremia presenting with fever, hypotension and meningitis. the patient had no exposure to contaminated sources except from khat chewing, which we describe as a possible source of transmission for the first time. | 2011 | 22138599 |
| sepsis and pericarditis caused by campylobacter fetus: case report and literature review. | heretofore, campylobacter infections have been predominantly associated with gastrointestinal manifestations. over the past two decades, an increasing number of case reports have suggested that the spectrum of disease is much broader. to date, only 10 cases of myocarditis/pericarditis in patients with c. fetus have been reported in the english literature out of which at least 4 patients have died. we describe here a further case to include as we review the literature. | 2011 | 22016899 |
| comparison of electrolyzed oxidizing water with other antimicrobial interventions to reduce pathogens on fresh pork. | to date, the effectiveness of electrolyzed oxidizing (eo) water against bacteria associated with fresh pork has not been determined. using a hand-held, food-grade garden sprayer, distilled water (w), chlorinated water (cl; 25 ppm), 2% lactic acid (la), acidic eo water (eoa), or "aged" acidic eo water (aeoa; stored at 4 °c for 24 h) was sprayed (15 s) onto pork bellies inoculated with feces containing listeria monocytogenes (lm), salmonella typhimurium (st), and campylobacter coli (cc). remaining ... | 2004 | 22062415 |
| culture-based indicators of fecal contamination and molecular microbial indicators rarely correlate with campylobacter spp. in recreational waters. | campylobacter spp. are the leading cause of gastroenteritis worldwide. most human infections result from contaminated food; however, infections are also caused by recreational waterway contamination. campylobacter culture is technically challenging and enumeration by culture-based methods is onerous. thus, we employed qpcr to quantify campylobacter spp. in fresh- and marine-water samples, raw sewage and animal feces. multiplex pcr determined whether campylobacter jejuni or c. coli, most commonly ... | 2011 | 22048429 |
| pathogenic potential of campylobacter ureolyticus. | the recent detection and isolation of the aflagellate campylobacter ureolyticus (previously known as bacteroides ureolyticus) from intestinal biopsy specimens and fecal samples of children with newly diagnosed crohn's disease led us to investigate the pathogenic potential of this bacterium. adherence and gentamicin protection assays were employed to quantify the levels of adherence to and invasion into host cells. c. ureolyticus unswcd was able to adhere to the caco-2 intestinal epithelial cell ... | 2011 | 22124656 |
| cj1386 is an ankyrin-containing protein involved in heme trafficking to catalase in campylobacter jejuni. | campylobacter jejuni, a microaerophilic bacterium, is the most frequent cause of human bacterial gastroenteritis. c. jejuni is exposed to harmful reactive oxygen species (ros) produced during its own normal metabolic processes and during infection from the host immune system and from host intestinal microbiota. these ros will damage dna and proteins and cause peroxidation of lipids. consequently, identifying ros defense mechanisms is important for understanding how campylobacter survives this en ... | 2012 | 22081390 |
| applications of pcr (real-time and masstag) and enzyme-linked immunosorbent assay in diagnosis of respiratory infections and diarrheal illness among deployed u.s. military personnel during exercise balikatan 2009, philippines. | laboratory-based surveillance for diarrheal and respiratory illness was conducted at the 2009 republic of the philippines-united states balikatan exercise to determine the presence of specific pathogens endemic in the locations where the military exercises were conducted. ten stool and 6 respiratory specimens were obtained from individuals meeting case definitions for diarrhea or respiratory illness. stool specimens were frozen in dry ice and remotely tested using enzyme-linked immunosorbent ass ... | 2011 | 22128641 |
| prevalence of selected bacterial and parasitic agents in feces from diarrheic and healthy control cats from northern california. | background: bacterial and parasitic agents are commonly implicated as causes of diarrhea in cats, but there is a paucity of information evaluating epidemiological and prevalence factors associated with most of these organisms in cats. objectives: determine the prevalence of selected enteropathogens in diarrheic and nondiarrheic cats. animals: a total of 219 diarrheic and 54 nondiarrheic cats. methods: prospective study. fresh fecal specimens were submitted for centrifugation flotation, culture, ... | 2011 | 22182203 |
| antioxidant and antimicrobial effects of four garlic-derived organosulfur compounds in ground beef. | the antioxidant and antimicrobial protection of diallyl sulfide (das), diallyl disulfide (dads), s-ethyl cysteine (sec), n-acetyl cysteine (nac) in ground beef against discoloration, lipid oxidation and microbial contamination were studied. the exogenous addition of these garlic-derived organosulfur compounds significantly delayed both oxymyoglobin and lipid oxidations (p<0.05). the antioxidant protection from these organosulfur compounds was dose-dependent (p<0.05), and showed significantly gre ... | 2003 | 22061980 |
| network analysis and protein function prediction with the prodistin web site. | interactions between macromolecules are deciphered to gain information about biological processes and protein function. this information is hidden in large interaction networks, yet very complicated to dissect. in this context, the prodistin web site is dedicated to the clustering of network proteins according to the identity of their interaction partners, and to the subsequent functional annotation of these clusters. it allows analysing functionally networks and eventually leads to the predicti ... | 2012 | 22144161 |
| detection of periodontal pathogens in newborns and children with mixed dentition. | we report the age-related prevalence of red complex periodontal pathogens, porphyromonas gingivalis, treponema denticola, and tannerella forsythia, along with four strains of orange complex pathogens. the bacteria present in samples isolated from tongue, cheek, and subgingival sulcus in edentulous newborns and children with mixed dentition were monitored by polymerase chain reaction (pcr). p. gingivalis was not detected in any site of any subject in the two groups tested. however, t. denticola w ... | 2011 | 21928086 |
| regulation of perr expression by iron and perr in campylobacter jejuni. | campylobacter jejuni is a leading food-borne pathogen causing gastroenteritis in humans. although oxyr is a widespread oxidative stress regulator in many gram-negative bacteria, c. jejuni lacks oxyr and instead possesses the metalloregulator perr. despite the important role played by perr in oxidative stress defense, little is known about the factors influencing perr expression in c. jejuni. in this study, a perr promoter-lacz fusion assay demonstrated that iron significantly reduced the level o ... | 2011 | 21908670 |
| development and validation of a comparative genomic fingerprinting method for high-resolution genotyping of campylobacter jejuni. | campylobacter spp. are a leading cause of bacterial gastroenteritis world-wide. the need for molecular subtyping methods with enhanced discrimination in the context of surveillance- and outbreak-based epidemiologic investigations of campylobacter spp. is critical to our understanding of sources and routes of transmission and the development of mitigation strategies to reduce the incidence of campylobacteriosis. we describe the development and validation of a rapid and high-resolution comparative ... | 2011 | 22170908 |
| analysis of the liv system of campylobacter jejuni reveals alternative roles for livj and livk in commensalism beyond branched-chain amino acid transport. | campylobacter jejuni is a leading cause of diarrheal disease in humans and an intestinal commensal in poultry and other agriculturally important animals. these zoonotic infections result in significant amounts of c. jejuni present in the food supply to contribute to disease in humans. we previously found that a transposon insertion in cjj81176_1038, encoding a homolog of the escherichia coli livj periplasmic binding protein of the leucine, isoleucine, and valine (liv) branched-chain amino acid t ... | 2011 | 21949065 |
| antibacterial activity of three medicinal thai plants against campylobacter jejuni and other foodborne pathogens. | leaves of adenanthera pavonina, moringa oleifera and annona squamosa are used in traditional thai medicine to treat dysentery and other diseases. this study investigated the antibacterial activity of these plants against six species of foodborne pathogen. methods and solvents employed to extract active constituents were optimised using the disc diffusion assay. phytochemical analysis of the optimised extracts was performed by thin layer chromatography (tlc). minimum inhibitory concentrations (mi ... | 2011 | 21878033 |
| whole-genome comparison of two campylobacter jejuni isolates of the same sequence type reveals multiple loci of different ancestral lineage. | campylobacter jejuni st-474 is the most important human enteric pathogen in new zealand, and yet this genotype is rarely found elsewhere in the world. insight into the evolution of this organism was gained by a whole genome comparison of two st-474, flaa svr-14 isolates and other available c. jejuni isolates and genomes. the two isolates were collected from different sources, human (h22082) and retail poultry (p110b), at the same time and from the same geographical location. solexa sequencing of ... | 2011 | 22096527 |
| comparison of performance of the novel chromogenic spectra vre agar to that of bile esculin azide and campylobacter agars for detection of vancomycin-resistant enterococci in fecal samples. | a total of 142 stool specimens were evaluated for vancomycin-resistant enterococcus (vre). twenty-four-hour sensitivities and specificities, respectively, were 98% and 95% for spectra vre chromogenic agar (remel, lenexa, ks), 86% and 92% for bile esculin azide with vancomycin (beav; remel), and 96.5% and 92% for campylobacter agar (campy; remel). spectra vre and campy are significantly more sensitive at 24 h than beav. | 2011 | 21880967 |
| crystal structure of campylobacter jejuni chuz: a split-barrel family heme oxygenase with a novel heme-binding mode. | the heme oxygenase chuz is part of the iron acquisition mechanism of campylobacter jejuni, a major pathogen causing enteritis in humans. chuz is required for c. jejuni to use heme as the sole iron source. the crystal structure of chuz was resolved at 2.5å, and it was revealed to be a homodimer with a split-barrel fold. one heme-binding site was at the dimer interface and another novel heme-binding site was found on the protein surface. heme was bound in this site by four histidine side-chains th ... | 2011 | 22020097 |
| pulsed-field gel electrophoresis analysis of more than one clinical isolate of campylobacter spp. from each of 49 patients in new zealand. | pulsed-field gel electrophoresis (pfge) analysis demonstrated that while 76% of patients had only one genotype of campylobacter, 10% carried two different but related genotypes (dice coefficients > 0.78), and 14% carried at least two unrelated genotypes (dice coefficients < 0.65). this supports the clustering of campylobacter isolates with similar pfge patterns, highlights the need to analyze multiple isolates from both sources and patients, and confirms that caution should be exercised before e ... | 2011 | 22116155 |
| campylobacter fetus as cause of prosthetic valve endocarditis. | a 65-year-old woman who had previously undergone aortic root replacement with a bioprosthetic valve (bentall operation) in treatment of annuloaortic ectasia became feverish after developing dental caries and was admitted to our hospital. transesophageal echocardiography showed an 18 × 4-mm vegetation on her prosthetic valve. campylobacter fetus was isolated on blood cultures, and she was diagnosed with infectious endocarditis. aggressive combined antibiotic treatment was effective for her recove ... | 2011 | 22163142 |
| prevalence and antimicrobial susceptibility of campylobacter spp. in live and dressed chicken in jordan. | abstract a total of 140 broiler flocks presented for slaughtering at amman slaughterhouse were tested for campylobacter spp. via collection of cloacal swabs from live birds, feathered skin samples at prescalding, and skin samples at postscalding (62°c or 57°c scalding temperature), postevisceration, and postchilling. the results indicated that 40% of the flocks tested by cloacal swabs, 34% at prescalding, 32% at post 57°c scalding, and 32% postevisceration were harboring campylobacter jejuni. ... | 2011 | 21988398 |
| a preliminary study of salmonella, verocytotoxigenic escherichia coli/escherichia coli o157 and campylobacter on four mixed farms. | the aims of this study were to investigate the incidence of salmonella, verocytotoxigenic escherichia coli (vtec)/escherichia coli o157 and campylobacter on four mixed farms and to characterize the isolates in terms of a range of virulence factors. eighty-nine composite (five different samples from the same animal species combined) faecal [cattle (24), pigs (14), sheep (4), poultry (4), horses (7), deer (4), dogs (9), rodents (2) and wild birds (20)] samples, 16 composite soil samples plus 35 in ... | 2011 | 21951421 |
| the role of campylobacter jejuni cytolethal distending toxin in gastroenteritis: toxin detection, antibody production, and clinical outcome. | the role of campylobacter jejuni cytolethal distending toxin (cdt) on clinical outcome after gastroenteritis was investigated. clinical data, blood serum samples, and campylobacter spp. isolated, from each of 30 patients were collected over a period of 6 months. the cdt encoding genes, cdtabc, characterized by pcr, revealed that all but one of the c. jejuni strains had the wild-type sequence. sequencing of cdtabc from this strain showed two major deletions. from all of the strains, cdt titers we ... | 2011 | 21851421 |
| the signaling pathway of campylobacter jejuni-induced cdc42 activation: role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor vav2. | abstract: background: host cell invasion by the foodborne pathogen campylobacter jejuni is considered as one of the primary reasons of gut tissue damage, however, mechanisms and key factors involved in this process are widely unclear. it was reported that small rho gtpases, including cdc42, are activated and play a role during invasion, but the involved signaling cascades remained unknown. here we utilised knockout cell lines derived from fibronectin-/-, integrin-beta1-/-, focal adhesion kinase ... | 2011 | 22204307 |
| toxic megacolon. | toxic megacolon represents a dreaded complication of mainly inflammatory or infectious conditions of the colon. it is most commonly associated with inflammatory bowel disease (ibd), i.e., ulcerative colitis or ileocolonic crohn's disease. lately, the epidemiology has shifted toward infectious causes, specifically due to an increase of clostridium difficile-associated colitis possibly due to the extensive (ab)use of broad-spectrum antibiotics. other important infectious etiologies include salmone ... | 2011 | 22009735 |
| extracellular deoxyribonuclease production by periodontal bacteria. | palmer lj, chapple ilc, wright hj, roberts a, cooper pr. extracellular deoxyribonuclease production by periodontal bacteria. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01451.x © 2011 john wiley & sons a/s background and objective: whilst certain bacteria have long been known to secrete extracellular deoxyribonuclease (dnase), the purpose in microbial physiology was unclear. recently, however, this enzyme has been demonstrated to confer enhanced virulence, enabling bacteria to evade the ... | 2011 | 22150619 |
| miller-fisher syndrome in association with enterovirus infection. | miller-fisher is a rare syndrome of childhood that presents with external ophthalmoplegia, ataxia, and areflexia. it has been mainly associated with a preceding campylobacter infection and less commonly with other bacterial or viral infections. this report describes, for the first time, a child with miller-fisher syndrome and documented enterovirus infection, as it was proven by the isolation of enterovirus from cerebrospinal fluid by polymerase chain reaction testing. | 2011 | 21968982 |