| the effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. | 1. the effects of ca2+ (mainly by using egta buffers), ph, atp and adp on the activity of the 2-oxoglutarate dehydrogenase complex from pig heart were explored. 2. ca2+ (about 30 micrometer) resulted in a decrease in the apparent km for 2-oxoglutarate from 2.1 to 0.16 mm (at ph 7) without altering the maximal velocity. at 0.1 mm-oxoglutarate there was a 4--5-fold activation by ca2+, with an apparent km for ca2+ of 1.2 micrometer. a similar activation was also observed with sr2+ (km 15.1 micromet ... | 1979 | 39549 |
| [synthesis of several phenoxymethylphenyl derivatives with local-anesthetic activity (author's transl)]. | 1. several 4-phenoxymethyl-procaine derivatives (iv) were synthetised in order to investigate the influence of the intermediate chain on the activity. 2. by replacing the ch2-ch2-group in fomocain by a coo-group we succeeded in doubling the efficacy of this local anesthetic. 3. the type and position of the hetero atoms, n,s and o in the intermediate chain of the procaine (i), xylocaine (ii), cinchocaine (iii) and phenoxymethyl-procaine (iv) series have in each of these series quite a different e ... | 1979 | 39578 |
| [synthesis and h2-antihistaminic activity of ring methylated metiamide analogues. 4th communication: h2-antihistaminic agents (author's transl)]. | in studies on structure-activity relationships of histamine h2-receptor antagonists, the influence of different imidazole ring methylation on the h2-antagonist activity was investigated. 2-methyl-, 5-methyl-, 2,5-dimethyl- and unsubstituted analogues of metiamide were prepared and tested. while 5-methyl- and unmethylated analogues with a thiourea group proved to be quite active, the 2-methyl- and 2,5-dimethyl-derivatives, as well as those with a urea group, had only low h2-antihistaminic activit ... | 1979 | 39579 |
| [on the mechanism of the positive inotropic effect of triamterene on the myocardium (author's transl)]. | the influence of triamterene on the contractile force and the cellular electrolyte content and exchange was studied in isolated, electrically stimulated guinea-pig atria. 1. triamterene (40 to 200 mumol/l) produces a positive inotropic effect which is most pronounced when the extracellular calcium concentration is reduced (1.2 to 0.6 mmol/l) or the contractile force is diminished by pentobarbital (400 mumol/l). the inotropic action of triamterene was shown to be independent of the rate of stimul ... | 1979 | 39580 |
| (diisopropylphosphoryl)serine proteinases. proton and phosphorus-31 nuclear magnetic resonance-ph titration studies. | | 1979 | 39591 |
| induction of a chloride conductance in gastric vesicles by limited trypsin or chymotrypsin digestion or ageing. | transport activity of the hog gastric (h+ + k+)-atpase system was measured either as the formation of proton gradient using the dye probe acridine orange or as the formation of a proton diffusion potential using the cyanine dye 3,3'-diethyloxdicarbocyanine iodide in the presence of the protonophore tetrachlorosalicylanilide. the development of these gradients has been compared in k+ media in the presence of either cl- or so4-2 as the anionic species. this comparison of proton diffusion potential ... | 1979 | 39602 |
| diminution by vesicular stomatitis virus of acute graft vs host mortality in mice. | | 1979 | 39680 |
| comparison of the beta-adrenoceptor effects of soterenol and its 3-hydroxy, 4-sulphonamido isomer (mj6987-1) in isolated tissues from the guninea-pig. | 1. soterenol and its 3-hydroxy, 4-methanesulphonamido isomer (mj6987-1) were compared with isoprenaline for beta-adrenoceptor mediated effects in guinea-pig atrial, tracheal, uterine and ileal preparations. in addition, mj6987-1 was tested for its effects in the atria of cats, rabbits and rats. 2. soterenol had a lower intrinsic activity and was approximately two to six times less active than isoprenaline in all preparations. 3. mj6987-1 was a full agonist, being some 30--200 times less active t ... | 1979 | 39696 |
| fetal respiration: a review of two techniques for observation. | | 1979 | 39701 |
| prazosin and phentolamine: comparative cardiovascular and autonomic profiles. | | 1978 | 39713 |
| the effects of dihydrochandonium and other chandonium analogues on neuromuscular and autonomic transmission. | | 1979 | 39992 |
| restoration of slow responses in hypoxic heart muscle by alkaline ph. | | 1979 | 40040 |
| [relationship between guanylate cyclase and calcium ion in the smooth muscle]. | | 1978 | 40056 |
| [stimulating effects of alanine and glycine on guinea-pig taenia coli (author's transl)]. | effects of alanine and glycine on the mechanical and electrical activities of guinea-pig taenia coli were investigated. alanine (0.1--10 mm) and glycine (0.5--10 mm) produced a dose dependent contraction of guinea-pig taenia coli. the stimulating effects of alanine and glycine were not inhibited in the presence of atropine (5 mum), tetrodotoxin (0.1 micrograms/ml), diphenhydramine (4 mum), methysergide (3 mum), strychnine (10 mum), and were not influenced by treatment with indomethacin (3 mum). ... | 1979 | 40057 |
| [influence of pyloroplasty and pyloric stenosis on motoric and secretory function of the stomach after selective proximal vagotomy--an experimental study (author's transl)]. | in conscious fullgrown minipigs simple spv alone, spv and pyloric stenosis and spv and pyloroplasty were performed. after a liquid test meal the motoric and secretory function of the stomach were examined simultaneously by a modified method of intestinal perfusion and aspiration. after simple spv initially a marked decrease of gastric volume and normal emptying into the duodenum were found. with additional pyloric stenosis no significant change was found. the pyloroplasty lead to an increase of ... | 1979 | 40077 |
| stimulation of beta-adrenoceptors by dobutamine in the guinea-pig atrium and tracheal chain. | | 1979 | 40138 |
| [studies in swine for the cause of development of testicular abnormalities following archidepexy]. | | 1979 | 40141 |
| synthesis of enkephalins by guinea-pig striatum in vitro. | a method for obtaining incorporation of labelled amino acids into enkephalins of guinea-pig striatum in vitro and isolating the labelled enkephalins is described. the incorporation of [3h]tyrosine increases with time after a delay of 2 h. cycloheximide added during this time, but not at later stages, inhibits incorporation. the results indicate that the enkephalins are produced locally, probably by ribosomal synthesis. the lag period may be due to the time required for the synthesis of precursor ... | 1979 | 40246 |
| on the effect of sulphasalazine on the prostaglandin system and the defective prostaglandin inactivation observed in experimental ulcerative colitis. | | 1979 | 40410 |
| [effect of vitamin d and vitamin e on the erythrocyte membrane. i. effect on in vitro osmolar resistance and lysis]. | as in the case of retinol, low doses of cholecalcipherol and alpha-tocopherol "in vitro" increase the osmotic resistance of red blood cells, while high doses have a lytic effect on the erythrocytes of various animal species (e.g.: man, sheep, rabbit, guinea-pig, mouse, rat) with the exception of the chicken. the haemolytic effect of cholecalcipherol is less intense than that of retinol; alpha-tochopherol, while causing even less haemolysis than cholecalcipherol, involves a remarkable loss of k+ ... | 1978 | 40412 |
| cellular localization of saint louis encephalitis virus replication. | replication of saint louis encephalitis (sle) virus was inhibited when ps cells were treated with actinomycin d, daunomycin or cordycepin during the first 9 hr after infection. autoradiography of sle virus-infected pulse labelled cells demonstrated that viral rna synthesis is localized within the nuclear area. nuclei purified from cells after 12 hr of infection contained heterogeneous 20 s to 26 s viral rna but no sle virus genome sized 43 s rna. later during infection, nuclei isolated from infe ... | 1979 | 40415 |
| quantitative and rapid assays of togaviruses by immunofluorescence. | for the quantitative assay of selected togaviruses, suspensions of bhk cells were inoculated with virus and grown in spinner cultures. at intervals, dependent on the growth characteristics of the viruses, about 10(3) cells were centrifuged on to microscope slides and then stained with fluorescent antibody. for rapid demonstration (2--3 hr) of specific viral antigens, virus was bound in successive dilutions onto microscope slides and stained. binding of specific anti-virus antibodies in both meth ... | 1979 | 40420 |
| purification of microtubule protein from beef brain and comparison of the assembly requirements for neuronal microtubules isolated from beef and hog. | | 1979 | 40455 |
| crystalloids of actin-like filaments in the sertoli cell of the swine testis. | normal swine testes, congenital cryptorchid swine testes, and normal human tests were exposed to hmm (heavy meromyosin) after either glycerination or saponin treatment in order to determine whether the fine filaments composing the crystalloids in the sertoli cells of the cryptorchid swine testes bind hmm to form arrowhead complexes. short bundles of microfilaments observed in the basal part of the sertoli cells in both normal and cryptorchid testes also bind hmm. similar bundles of hmm-bound fil ... | 1979 | 40460 |
| report on the pig and sheep blood group and polymorphic protein workshops (libĕchov, 9 to 11 august 1978). | | 1978 | 40465 |
| [synthesis and bioactivities of 2-oxo-naphtho (1,2-d)thiazolo(3,2-a)pyrimidine derivatives]. | | 1979 | 40538 |
| noncompetitive inhibition of soluble guanylate cyclase by 2'-deoxyguanosine-3'-monophosphate. | | 1979 | 40562 |
| cyclohexylphenoxy amidoximes and imidazolines with antidepressive and alpha-adrenergic activity. | the effect of variation of the cycloaliphatic residue position on pharmacological activity was studied in two series of cyclohexylphenoxy derivatives (a and b). (formula: see text) the ortho derivatives generally exhibit remarkably strong activity; (a) has an imipramine-like pharmacological profile; (b) with y = h is more active than naphazoline and xylomethazoline as vasoconstrictor. the meta and para substituted derivatives and all (b) derivatives with r = ch3 exhibited no definite or interest ... | 1979 | 40574 |
| isolation and properties of porcine thyroid fucokinase. | a 23 000-fold purification of porcine fucokinase (atp:6-deoxy-l-galactose 1-phosphotransferase, ec 2.7.1.52) has been achieved using a combination of ion-exchange, hydrophobic ligand, affinity, hydroxyapatite and molecular sieve chromatography. the enzyme was determined to have a subunit molecular weight of 78 180 +/- 4260 by sodium dodecyl sulfate chromatography and a tetrameric molecular weight of 309 200 +/- 4100 in the active state as determined by molecular sieve chromatography. the enzyme ... | 1979 | 40602 |
| comparative studies on immunologically and non-immunologically produced slow-reacting substances from man, guinea-pig and rat. | 1 slow-reacting substance of anaphylaxis (srs-a) was produced by antigen challenge of passively sensitized human lung and actively sensitized guinea-pig lung. 2 a slow-reacting substance (srs) was prepared from the peritoneal fluid of rats treated with calcium ionophore a23187. 3 these substances were extensively purified by charcoal adsorption, sephadex g-15 gel filtration, ether extraction and reverse phase high pressure liquid chromatography. 4 the three substances are pharmacologically, chem ... | 1979 | 40646 |
| the effects of high pressure helium and nitrogen on the release of acetylcholine from the guinea-pig ileum. | 1 the effects of high pressures of helium and of nitrogen on acetylcholine release were tested using the guinea-pig ileum as a model preparation. a superfusion system was designed in which this tissue could be maintained under physiological conditions in a high pressure chamber.2 helium, at a pressure of 136 atm slightly increased the spontaneous output of acetylcholine but produced no significant changes at 68 atm (136 atm is close to the lethal pressure for small mammals).3 the acetylcholine r ... | 1979 | 40648 |
| the effects of temperature and ionic environment on antagonists binding to cardiac beta-adrenoceptors [proceedings]. | | 1979 | 40655 |
| is wb 4093 a selective presynaptic alpha 2-adrenoceptor antagonist? [proceedings]. | | 1979 | 40659 |
| the reaction of the cancerostatic ccnu with the catalytic site of transglutaminase. | the experiments in this paper show for the first time that ccnu, a nitrosourea, inhibits transglutaminase (an enzyme believed to be involved in tissue proliferation) on account of its cyclohexyl-isocyanate moiety. | 1979 | 40689 |
| maturation- and species-related differences in inotropic response to isoproterenol. | | 1979 | 40739 |
| [effect of beta-adrenergic drugs on humoral immune response factors]. | the authors examined the influence of beta-adrenergic stimulators isoprenaline and salbutamol as well as beta-adrenergic blockers propranolol, practolol and pindolol on the proliferation of cells, forming plaques, 7s-immunoglobulins, hemagglutination titres and hemolytic activity of the complement. primary stimulation with subsequent inhibition was induced by beta-adrenergic agonists and inhibition--by beta blocker propronanol in a base of 10 mg/kg on the proliferation of cells, forming antibodi ... | 1979 | 40786 |
| proceedings of the association of european pediatric cardiologists. xvith annual general meeting, 9--12 may 1978, budapest, hungary. abstracts. | | 1979 | 40796 |
| the origin of orchiopexy-induced testicular lesions in the pig. | cooling experiments of abdominal testes in adult, naturally cryptorchid pigs indicate that spermatogenic arrest in abdominal testes is not due to an inborn defect, but is caused solely by maintenance of the testis at abdominal temperature. it is postulated that failure of spermatogenic cells to differentiate after orchiopexy results from surgical trauma. evaluation of the orchiopexy procedure revealed that simple manipulation of a normally descended testis may give rise to damage to the spermato ... | 1979 | 40830 |
| pathogenic species of the genus haemophilus and streptococcus pneumoniae produce immunoglobulin a1 protease. | thirty-seven strains of the genus haemophilus and five strains of streptococcus pneumoniae were examined for their ability to produce extracellular enzyme that cleaves immunoglobulin molecules. all strains of h. influenzae, h. aegyptius, and s. pneumoniae elaborated enzyme that selectively cleaved human immunoglobulin a1 (iga1) myeloma proteins but was inactive against a variety of other proteins including human iga2, igg, and igm, porcine and bovine secretory iga, human and bovine serum albumin ... | 1979 | 40878 |
| purification and properties of biliverdin reductases from pig spleen and rat liver. | biliverdin reductase was purified from pig spleen soluble fraction to a purity of more than 90% as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. the enzyme was a monomer protein with a molecular weight of about 34,000. its isoelectric point was at 6.1-6.2. the enzyme was strictly specific to biliverdin and no other oxiodoreductase activities could be detected in the purified enzyme preparation. the purified enzyme could utilize both nadph and nadh as electron donors for th ... | 1979 | 40968 |
| a combined alkali extraction--ethidium bromide technique for the measurement of dna in small pieces of tissue. | alkaline solutions (0.1--0.5 n naoh) at elevated temperatures can be used to extract dna from small pieces of tissue. rna is destroyed by the treatment. in tissues which have been previously exposed to tritiated thymidine, aliquots from the extracting solution can be used directly for the determination of dna by ethidium bromide fluorescence and radioactivity in both dna and the nucleotide pool. | 1979 | 41020 |
| [regulatory mechanisms of membrane lipids--with reference to environmental adaptation (author's transl)]. | | 1979 | 41021 |
| purification and properties of transketolase from pig liver. i. an attempt to resolve the enzyme into apoenzyme and cofactors. | transketolase, sedoheptulose-7-phosphate: d-glyceraldehyde-3-phosphate glycolaldehyde-transferase [ec 2.2.1.1], was extracted from pig liver and purified 96-fold by ammonium sulfate fractionation, followed by column chromatography using deae-cellulose and a sephadex g-200. transketolase from pig liver was stable at ph 6.0 and above, whereas it was unstable at lower ph values. it could be resolved into apoenzyme and thiamine pyrophosphate in an acidic medium, in contrast to baker's or brewer's ye ... | 1979 | 41031 |
| pa2 values of selective beta-adrenoceptor antagonists on isolated atria demonstrate a species difference in the beta-adrenoceptor populations mediating chronotropic responses in cat and guinea-pig. | pa2 values for atenolol (beta 1-selective) and alpha-methylpropranolol (beta 2-selective) have been determined on isolated atria of cat and guinea-pig using noradrenaline (beta 1-selective) and fenoterol (beta 2-selective) as agonists. on guinea-pig atria, the pa2 values did not vary with the agonist used. on cat atria the pa2 for atenolol was greater with noradrenaline than with fenoterol and the pa2 for alpha-methylpropranolol was greater with fenoterol than with noradrenaline. fenoterol was 2 ... | 1979 | 41041 |
| are antihistamines sedative via a blockade of brain h1 receptors? | | 1979 | 41044 |
| responses of guinea-pig lung parenchymal strips to prostaglandins and some selected autacoids. | | 1979 | 41051 |
| pharmacological data on crinia-angiotensin ii. | | 1979 | 41055 |
| cardiovascular studies with impromidine (sk&f 92676), a new very potent and specific histamine h2-receptor agonist. | impromidine (sk & f 92676) has recently been identified as a potent and specific histamine h2-receptor agonist. the present paper describes some cardiovascular studies with the drug. impromidine lowers blood pressure in cats and rats by interaction with h2-receptors. during continuous intravenous infusions of impromidine, the fall in blood pressure is due to a reduction in total peripheral resistance; cardiac output increases during hypotension. the responses to impromidine are similar to respon ... | 1979 | 41056 |
| non-competitive-non-equilibrium alpha-adrenoceptor blocking properties of n-benzyl iodoacetamide, betsamide. | n-benzyl iodoacetamide, betsamide, at 10 mg kg-1 i.v. blocked the hypertensive and contractile responses of the nictitating membrane of the cat to adrenaline. the blockade had a lag period before full development. pretreatment of cats with betsamide for 7 or 18 h showed a non-equilibrium type of alpha-adrenoceptor blockade. the responses of the nictitating membrane to adrenaline were markedly depressed and did not recover after high doses of adrenaline. in the same cats, adrenaline caused a prof ... | 1979 | 41059 |
| degradation of carrageenan for the experimental production of ulcers in the colon. | | 1979 | 41075 |
| the nature of the negative endocochlear potentials produced by anoxia and ethacrynic acid in the rat and guinea-pig. | 1. the alterations in the na+ and k+ concentrations of the cochlear endolymph and in the endocochlear potential were followed simultaneously by means of ion-sensitive and conventional micro-electrodes during simple anoxia, during anoxia after i.v. ethacrynic acid and after i.v. ethacrynic acid alone. the endolymphatic ph changes were measured separately and the effect of perilymphatic ethacrynic acid upon the endocochlear potential was investigated. 2. the over-all na+:k+ permeability ratio for ... | 1979 | 41092 |
| gall-bladder fluid and electrolyte transport in the presence of butyrate in bicarbonate-free solutions [proceedings]. | | 1979 | 41094 |
| electromechanical effects of ph in guinea-pig cardiac ventricular muscle [proceedings]. | | 1979 | 41096 |
| effect of carbohydrates and control of culture ph on beta toxin production by clostridium perfringens type c. | clostridium perfringens type c strain cn 5384 produced a higher level of beta toxin in a controlled ph medium containing 1% glucose, starch, or sucrose than in media with dextrin, fructose, or raffinose. toxin synthesis was not related to the growth yield. the effect of glucose on beta toxin production by 11 strains was investigated with and without control of the culture ph at 7.5. strain cn 5386 produced distinctly higher toxin when the ph of the culture was maintained at 7.5, compared with un ... | 1979 | 41161 |
| srs-a and other mediators. slow reacting substance biosynthesis, characterization and purification. | | 1979 | 41174 |
| the development of anti-allergic drugs. | | 1979 | 41176 |
| in vitro studies of antigen-induced bronchospasm. | | 1979 | 41177 |
| the importance of choice of agonist in studies designed to predict beta 2 : beta 1 adrenoceptor selectivity of antagonists from pa2 values on guinea-pig trachea and atria. | 1. pa2 values have been obtained for propranolol, butoxamine, h35/25 and atenolol on guinea-pig isolated trachea and atria (rate) using noredrenaline (beta 1-selective), isoprenaline (non-selective) and fenoterol (beta 2-selective) as agonists. 2. pa2 values varied with the agonist used on trachea but not on atria and, therefore, trachea : atria selectivity values varied with the agonist used. 3. it is suggested that the best estimate of the selectivity of an antagonist between beta 2- and beta ... | 1979 | 41190 |
| dopaminergic antagonism of l-5-hydroxytryptophan-induced myoclonic jumping behavior. | we studied the effect of dopamine agonists (levodopa, apomorphine, lergotrile, and m-7 [2(dimethylamino)5,6-dihydroxytetralin] on myoclonic jumping behavior in young male guniea pigs. all these agents had a significant antagonistic effect on the frequency of this serotonin-mediated behavior. the duration of the antagonism corresponded in all cases to the duration of stereotyped chewing behavior induced by these agents alone. the dopamine antagonist haloperidol potentiated jumping behavior. there ... | 1979 | 41197 |
| the presence of the heat-stable neurotoxin in the pertussis cells. | | 1978 | 41206 |
| specific protection of the binding sites of d-ala2-d-leu5-enkephalin (delta-receptors) and dihydromorphine (mu-receptors). | phenoxybenzamine causes a long-lasting inactivation of the opiate receptors of the mu- and delta-type in homogenates of guinea-pig brain. the effect is selectively prevented when, before exposure to phenoxybenzamine, the homogenate is pre-incubated with ligands of high affinity for either of the two binding sites, i.e. dihydromorphine for the mu-receptor and tyr-d-ala-gly-phe-d-leu for the delta-receptor. in contrast, tyr-d-ala-gly-phe-l-leu amide, which has high affinities for both binding site ... | 1979 | 41257 |
| responses of the neonatal piglet bronchus to some autonomic and autacoid agents. | | 1979 | 41384 |
| anti-allergic properties of beta-adrenoceptor stimulants. | | 1979 | 41397 |
| retinal and choroidal contribution to retinal metabolism in vivo. a study in pigs. | the glucose metabolism of the retina was studied in vivo, by determining glucose, oxygen and lactate a-v differences for choroidal and retinal blood in pigs at different levels of intraocular pressure. at normal intraocular pressure the choroidal a-v differences were 0.07 and 0.11 mmol/l for glucose and oxygen respectively. the corresponding figures for the retina were 0.44 and 2.15. at increased levels of intraocular pressure the choroidal and retinal glucose and choroidal oxygen a-v difference ... | 1979 | 41411 |
| autoimmune response to acetylcholine receptors in myasthenia gravis and its animal model. | | 1979 | 41416 |
| annual examination of influenza virus infection among pigs in miyagi prefecture, japan: the appearance of hsw1n1 virus. | annual dissemination of swine and hong kong influenza viruses among hogs in miyagi prefecture, japan, was examined by virus recovery and serological tests. the serological examination revealed that two distinct influenza a viruses, h3n2 and hsw1n1, had caused dual epidemic in pigs since mid-1977. some individual sera contained antibodies against both strains. although positive sera against hong kong or swine influenza viruses appeared in the serosurvey throughout the year, the positive ratios in ... | 1979 | 41437 |
| comparison of capillary ear blood and arterial blood to validate capillary sampling as an accurate assay of blood gas in swine. | capillary sampling in swine can be performed as an accurate assay of arterial blood gases. studies with swine provided results similar to, or slightly more favorable than, those reported for human beings, depending upon which cutaneous technique was used on human beings. on the basis of free flow or arterilization of the cutaneous sample and of the correlation between capillary and arterial ph, co2 partial pressure (pco2), and o2 partial pressure (po2) values, the capillary sampling technique of ... | 1979 | 41465 |
| effects of clonidine, guanfacine and three imidazolidine derivatives related to clonidine on blood pressure, heart rate and gastric acid secretion in the anaesthetized rat. | the effects of histamine, guanfacine, clonidine (2,6-dichlorophenylimino-2-imidazolidine) and the 2,6-dibromo, 2,3- and 2,5-dichloroanalogues of clonidine were assessed on blood pressure, heart rate and gastric acid secretion in the anaesthetized rat, with lumen-perfused stomach. histamine (100 microgram/kg to 1 mg/kg) and clonidine (250 microgram/kg to 1 mg/kg) each caused acute increases in acid secretion, the magnitude and duration of which were dose-dependent: the secretory effect of clonidi ... | 1979 | 41494 |
| [the activity and properties of fructose-1,6-diphosphatase in various tissues (liver, kidneys, skeletal muscle, small intestine mucosa) in swine]. | the following parameters are recommended for activity determination of fdpase by release of inorganic phosphate at 37 degrees c of enzyme from liver and kidneys of swine: ph 7.5, 2 mmol concentration of fructose-1,6-diphosphate, 5 mmol concentration of mg ions, and ten minutes of incubation. when the activity of fdpase was analysed with temperatures of 22 degrees c, and 45 degrees c, rises were recorded up to the highest temperature. adta was strongly activating along with 2 mmol of mg ions in a ... | 1979 | 41501 |
| [electrophysiologic aspects of the hypoxic and ischemic myocardium]. | | 1979 | 41506 |
| on the properties of porcine elastase released from its complex with human alpha-1-antitrypsin by alkaline cleavage. | | 1979 | 41523 |
| purification of plant calmodulin by fluphenazine-sepharose affinity chromatography. | | 1979 | 41525 |
| a review of feline viral rhinotracheitis (feline herpesvirus i infection). | | 1979 | 41670 |
| proton-nuclear-magnetic-resonance/ph-titration studies of the histidines of pancreatic phospholipase a2. | the study by means of 1h nuclear magnetic resonance (nmr) of the histidines of phospholipase a2 isolated from porcine, bovine and equine pancreas is reported. assignment of the histidine resonances was achieved by comparison of different enzymes and the use of paramagnetic probes. ph titration curves for various histidyl resonances were obtained and compared in the presence and absence of calcium. calcium is shown to lower the pka of the active site histidine. the nmr results are compared with t ... | 1979 | 41713 |
| human intestinal brush-border sucrase: mechanism of sodium ion activation below ph7 [proceedings]. | | 1979 | 41786 |
| influence of extracellular ph on cardiodepressant activity of narcotics. | | 1979 | 41809 |
| the zig-zag tracheal strip. | | 1979 | 41921 |
| some membrane interactions with bepridil, a new antianginal agent. | | 1979 | 41937 |
| prostaglandin e-2-9-ketoreductase in ovarian tissues. | the existence of the enzyme prostaglandin e-2-9-ketoreductase which can convert prostaglandin e-2 to prostaglandin f-2 alpha was indicated in experiments with pig and human ovarian tissues in vitro, using radioimmunoassay methods and a superfusion technique. further studies involving radiotracer techniques demonstrated that the enzyme was localized in the high-speed (105 000 g) supernatant fraction of human, pig and rat luteal tissue and human stromal tissue. the enzyme was shown to be nadph-dep ... | 1979 | 41947 |
| studies on histamine h2 receptors coupled to cardiac adenylate cyclase. blockade by h2 and h1 receptor antagonists. | | 1979 | 42012 |
| non-adrenergic, non-cholinergic autonomic neurotransmission mechanisms. | | 1979 | 42027 |
| [pharmacologic spectrum of guanylhydrazones (proceedings)]. | | 1979 | 42091 |
| vesicular storage and release of cholinergic false transmitters. | | 1979 | 42111 |
| the growth of treponema hyodysenteriae and other porcine intestinal spirochaetes in a liquid medium. | a new simple method for the preparation of a liquid medium containing rabbit serum for the propagation of treponema hyodysenteriae and other porcine intestinal spirochaetes is described. the medium, when dispensed in shallow layers and sealed under 10 per cent co2 in nitrogen, had a redox potential not greater than -125mv and an initial ph of about 6.9 when buffered with bicarbonate. growth of t hyodysenteriae developed more rapidly and viable counts reached higher levels at 42 degrees c than at ... | 1979 | 42126 |
| catecholamine-mediated arrhythmias in acute myocardial infarction. experimental evidence and role of beta-adrenoceptor blockade. | ventricular fibrillation is a major mechanism of sudden death. the cellular link between catecholamine activity and the development of serious ventricular arrhythmias may be in the formation of cyclic adenosine monophosphate (camp). cyclic amp and agents promoting camp accumulation allow development of slow responses which, especially in the presence of regional ischaemia, could develop into ventricular fibrillation. the role of beta-antagonist agents in the therapy of acute myocardial infarctio ... | 1979 | 42151 |
| [action of aortic cathepsin d on serum low-density lipoproteins]. | action of aortic cathepsin d on low density lipoproteins /ldl/ from human serum was studied by means of analytical ultracentrifugation. cathepsin d intensively hydrolysed ldl, leading to decrease in the sedimentation coefficients of the product formed. the product of degradation of ldl possessing a sedimentation coefficient of 4.5 s /in 0,04 m kbr; 0,042 m nacl, 2 mm edta, 6 mm tris, ph 7.3 /contained apparently the minimal amount of proteins, which could still maintain the stability of partiall ... | 1979 | 42218 |
| [leukocidins of coccal microorganisms]. | | 1979 | 42241 |
| ph and temperature dependence of the double inhibition of d-glyceraldehyde-3-phosphate dehydrogenase by atp and quinaldate. | atp and quinaldate, two inhibitors of d-glyceraldehyde-3-phosphate dehydrogenase, act antagonistically if [pi] greater than 1 mm, at ph 7.5 and 25 degrees c. however, the type of interaction of the two inhibitors changes with ph and temperature. antagonism is strongest at ph values near neutrality and decreases at higher ph. above ph 9.5 the two inhibitors act nearly additively. at ph 8.5 and [pi] = 5 mm there is antagonism above 20 degrees c between the two inhibitors whereas there is synergy b ... | 1979 | 42270 |
| the pharmacological classification of adrenergic alpha 1 and alpha 2 receptors and their mechanisms of action. | | 1979 | 42274 |
| the schultz-dale reaction of the guinea-pig ileum: influence by beta-adrenoceptor agonists and theophylline. | one of the organs that can be used to study the schultz-dale reaction, is the guinea-pig ileum. the reaction is characterized by a specific pattern: a quick contraction, followed by a quick relaxation and a second, more slow contraction. a description is given of this typical reaction. selective inhibition of the slow contraction could be obtained using beta-adrenoceptor agonists. also theophylline inhibited the slow contraction, but this inhibition was only selective within a narrow range of co ... | 1979 | 42288 |
| suitability of coxiella burnetii strains for preparation of phase ii artificial diagnostic antigen for microagglutination test. | sensitivity in the microagglutination (ma) test of artificial (prepared by potassium periodate treatment) phase ii coxiella burnetii antigens depended on the c. burnetii strain used and the number of its chick embryo yolk sac passages. | 1979 | 42306 |
| an improved radioenzymatic assay for histamine in human plasma, whole blood, urine, and gastric juice. | a radioenzymatic method suitable for the assay of histamine in human blood, urine, plasma, and gastric juice is described. it differs from earlier methods by use of a histamine methyltransferase preparation from pig brain, of high activity tritiated s-adenosylmethionine, and of a heat precipitation step to reduce the previously noted interference from plasma constituents. the method is simpler than those requiring solvent extraction and concentration of histamine, gives recoveries in the range 8 ... | 1979 | 42342 |
| effect of ph on calcium accumulation and release by isolated fragments of cardiac and skeletal muscle sarcoplasmic reticulum. | | 1979 | 42354 |
| comparisons between hog intestinal peroxidase and bovine lactoperoxidase-compound i formation and inhibition by benzhydroxamic acid. | | 1979 | 42360 |
| stimulation of phosphatidylinositol turnover in various tissues by cholinergic and adrenergic agonists, by histamine and by caerulein. | studies are reported of the biochemical and pharmacological characteristics of the stimulation of phosphatidylinositol metabolism that is produced in appropriate target tissues by stimulation of various receptors that use ca(2+) as their second messenger. (1) muscarinic cholinergic and alpha-adrenergic phosphatidylinositol responses were observed in rat lacrimal gland, and a response to caerulein was detected in the longitudinal smooth muscle of guinea-pig ileum. (2) the muscarinic cholinergic p ... | 1979 | 42389 |
| the in vivo examination of the irreversible beta-adrenoceptor antagonist ro 03-7894 on cardiac rate and contractility. | 1. two benzofuran-2-ethanolamines ro 03-5255 (1-(5-acetylamino-benzofuran-2-yl)-1-hydroxy-2-isopropylaminoethane) and ro 03-7894 (1-(5-chloracetyl aminobenzofuran-2-yl)-1-hydroxy-2-isopropylaminoethane) which had previously been shown to exhibit respectively competitive and irreversible beta-adrenoceptor antagonism in guinea-pig isolated atria, were compared in vivo using isoprenaline-induced tachycardia of anaesthetized guinea-pigs and heart rate and contractility (dp/dtmax) of open-chest anaes ... | 1979 | 42499 |
| bone marrow transplantation in malignancy. | | 1979 | 42511 |
| [hygienic evaluation of metal items intended for contact with food products]. | | 1979 | 42602 |
| studies on trypsin inhibitors. part ix. synthesis and trypsin inhibitory activity of the duopentacontapeptide corresponding to the amino acid sequence of porcine pancreatic secretory trypsin inhibitor ii (kazal). | the synthesis of the protected duopentacontapeptide corresponding to the entire amino acid sequence i-52 of porcine pancreatic secretory trypsin inhibitor ii (kazal type) is described. the benzyloxycarbonyltetradecapeptide tert-butyloxycarbonylhydrazide (sequence 1-14) was selectively deblocked with trifluoroacetic acid and used to acylate, by the azide procedure, the peptide free base corresponding to the sequence 15-52. the isolated material was purified by ion exchange chromatography and the ... | 1979 | 42625 |
| oxidation of d-thiazolidine-4-carboxylic acid by hog kidney d-aminoacid oxidase. | d-thiazolidine-4-carboxylic acid is a good substrate for hog kidney d-aminoacid oxidase. data are presented showing that the only oxidation product is delta 3-thiazoline-4-carboxylic acid, which does not undergo further spontaneous degradation. thus, the oxidation of d-thiazolidine-4-carboxylic acid by d-aminoacid oxidase differs considerably from the oxidation of its l-isomer catalyzed by rat liver mitochondria which gives as final product n-formylcystine, possibly through the intermediate delt ... | 1979 | 42631 |