| adjuvant activity of bacterial glycolipids. | | 1976 | 825676 |
| [dispensary and clinical aspects of freshly diagnosed pulmonary tuberculosis accompanied by scanty recovery of bacilli]. | | 1976 | 825855 |
| acquired resistance against listeria monocytogenes in red mice and cf1 mice immunized with strains of bcg or mycobacterium tuberculosis. | groups of red mice and cf1 mice immunized intravenously with varying doses of a weak or a strong strain of bcg or a strain of mycobacterium tuberculosis were challenged 3 weeks after immunization with 0.1 or 0.2 ml 10(-2) listeria monocytogenes injected intravenously, simultaneously with a non-immunized control group. the acquired resistance was determined on the basis of the number of survivors and the survival times of the animals that died spontaneously. in the red mice, the strong bcg strain ... | 1976 | 826109 |
| potentiated lysosomal enzyme, bacteriostatic and bactericidal activities of peritoneal macrophages of mice treated with mer fraction of tubercle bacilli. | | 1976 | 826135 |
| tuberculous peritonitis: 43 years' expereince in diagnosis and treatment. | the clinical course of 70 patients with tuberculous peritonitis seen over a 43 year period has been reviewed. thirty-seven patients were diagnosed prior to the advent of anti-tuberculous chemotherapy and 33 after. clinical manifestations remained unchanged over the period of study. abdominal pain (93%), fever (63%), gastrointestinal upset (60%), weight loss (60%), and ascites (59%) continue to be the most common findings. females outnumbered males 2:1. in 89% of patients the duration of symptoms ... | 1976 | 826225 |
| comparative studies on the influence of dimethylsulfoxide (dmso) on reversion to sensitivity to isonicotinic acid hydrazide (inh) and rifampicin (rmp) in resistant strains of tubercle bacilli. | results of continuing studies on the influence of dimethylsulfoxide (dmso) on reversion of sensitivity to rifampicin (rmp) and isonicotinic acid hydrazide (inh) in tubercle bacilli are reported. nineteen strains of rmp-resistant bacilli, and 61 strains of ihn-resistant bacilli were studied. reversion to inh sensitivity was obtained in 19 of the 61 resistant strains examined. ten strains reverted completely, and 9 partly. all 19 rmp-resistant strains reverted to complete sensitivity. | 1976 | 826230 |
| preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissue of 'anergic' tuberculosis patients. | lymphocyte-transformation responses to mycobacterial antigens have been studied, using paired blood and lymph node samples from 'normal' ugandans, (hernia repairs or orthopaedic cases) or from patients with tuberculosis, mycobacterium ulcerans infection, or injection abscesses. the results suggest that in some individuals, antigen reactive cells, although absent from the periphery, may be demonstrable in the lymph nodes. this phenomenon is most striking in skin-test negative tuberculosis patient ... | 1976 | 826362 |
| granulomagenic activity of serologically active glycolipids from mycobacterium bovis bcg. | the granulomagenic properties of serologically active glycolipids a1, b2, b3, and c isolated from mycobacterium bovis bcg were studied. glycolipid a1, dissolved in olive and injected intradermally in guinea pigs, was able to elicit a granulomatous response that seemed to be of the nonallergic type. this granulomagenic activity was quite striking since only 2 mug was necessary to elicit the reaction. the b and c glycolipids were milder granulomagenic agents. glycolipid a1, dissolved in olive oil ... | 1976 | 826485 |
| a suggested role of a host-parasite lipid complex in mycobacterial infection. | on the basis of our previous observations and related literatures, was assumed tht cholesterol esters of host origin and phthiocerol dimycocerosate of bacterial origin are located as a lipid mixture around the periphery of pathogenic mycobacteria growing in vivo, probably within the phagocytic vacuole of macrophages. to examine the role of such a postulated lipid complex in mycobacterial infection, a model experiment was made in which tubercle bacilli grown in vitro were "coated" with both lipid ... | 1976 | 826675 |
| [comparative diagnostic value of the ziehl-neelsen and fluorescence microscopic methods and the loewenstein-jensen medium cultures for the detection of acid-fast bacilli]. | | 1976 | 826891 |
| [registered morbidity from active, sputum-positive pulmonary tuberculosis in the former konin district in the years 1966-1975]. | | 1976 | 826892 |
| [clinico-morphological comparisons in tuberculous patients with abacillary caverns in the lungs]. | | 1976 | 826900 |
| [morphology of initial stages in l-transformation of mycobacterium tuberculosis in electron microscopy scanning]. | | 1976 | 826901 |
| [use of isoniazid with nitrofuran and 5-nhq derivatives in experimental tuberculosis]. | | 1976 | 826902 |
| [drug resistance of mycobacterium tuberculosis in patients with serous exudative pleurisy]. | | 1976 | 826903 |
| [simple bacteriological methods of differentiating tuberculotic and nontuberculotic mycobacteria]. | | 1976 | 826904 |
| [use of pervomur for decontaminating the sputum of tuberculosis patients]. | | 1976 | 826905 |
| effect of concurrent administration of aspirin, indomethacin or hydrocortisone with gold sodium thiomalate against adjuvant-induced arthritis in the rat. | the activity of gold sodium thiomalate (gst) given i.m. to adjuvant-induced polyarthritic rats was studied alone or in combination with active doses of aspirin, indomethacin and hydrocortisone. in addition to paw volume and body weight changes, erythrocyte sedimentation rate, serum albumin/globulin and gold levels as well as plasma activities of beta-glucuronidase, acid phosphatase, lysozyme and lactic acid dehydrogenase were measured. in prophylactic studies the beneficial activity of gst was u ... | 1976 | 827200 |
| transient tuberculous meningitis. | tuberculous meningitis generally is considered to be relentlessly progressive, unless specific therapy is administered. the "aseptic meningitis" of a 56-year-old diabetic patient proved to be tuberculous and regressed spontaneously. review of the literature shows that spontaneous healing of tuberculous meningitis has been described and demonstrated previously. awareness of this entity and its recognition are important because this disease may be a focus for subsequent tuberculosis of other organ ... | 1976 | 827222 |
| [nonviable koch bacilli in pulmonary tuberculosis]. | | 1976 | 827467 |
| mycobacterial rna. a comparison with intact mycobacteria for suppression of murine tumor growth. | our experimental data imply the following: (1) an rna-rich fraction isolated from h37ra, and intact h37ra, are effective agents for suppression of tumor growth. (2) for suppression of two chemically-induced tumors with both rna and h37ra, direct contact with tumor is necessary. this may not be the case with other tumors in different strains of syngeneic mice. (3) the host's immunological system is a necessary component for inhibition of tumors by our test materials since there is no tumor suppre ... | 1976 | 827594 |
| reactions of cyanomethylbenzimidazoles. part iii. reaction of cyanomethylbenzimidazoles with isocyanates and isothiocyanates. | in the reaction of 2-cyanomethylbenzmidazole and their 1- and 5-methyl derivatives with aromatic isocyanates and isothiocyanates, 23 n-arylamides resp. thioamides of benzimidazolyl-2-alpha-cyanoacetic acid were obtained. the structure of the newly compounds (table 1) was confirmed by nmr and ir spectra. some of these shown moderate tuberculostatic activity in vitro. | 1976 | 827741 |
| [assessment of the results of bacteriologic studies in experimental renal tuberculosis]. | | 1976 | 827745 |
| [bactericidal effect of rifampicin]. | | 1976 | 827746 |
| bactericidal activity in vitro and in the guinea-pig of isoniazid, rifampicin and ethambutol. | serial viable counts on mycobacterium tuberculosis exposed in vitro to isoniazid, rifampicin and ethambutol in tween-albumin liquid medium showed no bactericidal synergism between isoniazid and rifampicin and no influence of ethambutol on the bactericidal activity of isoniazid or isoniazid plus rifampicin. guinea-pigs with moderately advanced experimental tuberculosis were treated fro 11 weeks with either (1) ethambutol, (2) isoniazid, (3) isoniazid plus ethambutol, (4) isoniazid plus rifampicin ... | 1976 | 827836 |
| transmission of tubercle bacilli: the effects of chemotherapy. | the important differences in the infectivity of the various forms of tuberculosis can be explained by quantitative data concerning the behaviour of the tubercle bacillus in man and the number of bacilli in the lesions and sputum. patients in whom tubercle bacilli can be detected by direct examination of the sputum smear are the main sources of transmission. moreover the individuals infected by them break down more often with the disease. in the individual patient, the use of antibacterial drugs ... | 1976 | 827837 |
| [synthesis and tuberculostatic activity of some derivatives of pyrazine-2-carboxylic acid]. | | 1976 | 827924 |
| lupus vulgaris: recovery of living tubercle bacilli 35 years after onset. | recovery of living tubercle bacilli in a lesion of 35 years' duration is intriguing if not novel, and creates many possible rationalizations relative to the relentless progressive course of lupus vulgaris. that the histopathological picture is not always diagnostic is exemplified in this case. | 1976 | 828092 |
| superoxide dismutase from mycobacterium tuberculosis. | 1. a superoxide dismutase [ec 1.15.1.1] was purified about 275-fold with a yield of 34% from mycobacterium tuberculosis, strain h37ra (attenuated strain), grown on a sauton medium for two months. the purified enzyme was homogeneous as judged by polyacrylamide gel electrophoresis, and by analytical ultracentrifugation and sedimentation equilibrium studies. 2. the molecular weight of the enzyme was estimated to be approximately 88,000 by sedimentation equilibrium analysis. since the molecular weig ... | 1976 | 828161 |
| an in vitro antituberculosis drug sensitivity of isolates of mycobacterium tuberculosis from human cases of pulmonary tuberculosis. | | 1976 | 828192 |
| [detection of tubercle bacilli in patients with pulmonary tuberculosis by sampling of bronchial sputum (author's transl)]. | | 1976 | 828213 |
| [chemistry, biology, and pathology of mycobacteria grown in vivo. 5. l-type growth of mycobacterium--simulation of the mode of growth in caseous foci]. | | 1976 | 828214 |
| [chemistry, biology, and pathology of mycobacteria grown in vivo. 6. mycobacterium in vivo, especially in caseous foci]. | | 1976 | 828215 |
| [comparative study of antiphosphatide and antiprotein antibodies by the hemagglutination reaction in pulmonary tuberculosis]. | | 1976 | 828258 |
| [certain indicators of cellular and humoral immunity in experimental isolated tuberculous lesions in the lungs]. | | 1976 | 828259 |
| [certain biochemical mechanisms of suppression of vital activity of mycobacterium tuberculosis under the effect of acridines]. | | 1976 | 828260 |
| incidence of niacin negative mycobacterium tuberculosis strains. | | 1976 | 828442 |
| primary resistence of mycobacteria in tuberculosis patients. | primary mycobactria resistance especially in some countries may be a serious obstacle to a successful therapy and the number of patients carrier of primary resistant mycobacteria remains almost at the same level in spite of the chemotherapeutic treatments and the usually rapid recover of the newly diagnosed cases. this may probably be attributed to the fact that the number of chronic patients, spitting resistant tubercle bacilli has remained almost the same, because these patients are eliminated ... | 1976 | 828501 |
| antiinflammatory reaction associated with murine l1210 leukemia. | mice bearing l1210 leukemia did not show impaired humoral or cellular immune response to antigenic stimulation druing the early stage of the tumor, and a depressed response was noted only in the terminal stage. l1210 cells were shown to suppress inflammatory reaction in vivo. | 1976 | 828582 |
| immune responses in experimental tuberculosis after bacillus calmette-guerin vaccination and challenge with h37rv. | | 1976 | 828615 |
| immune responses in experimental tuberculosis: effect of cortisone treatment. | | 1976 | 828616 |
| effect of guinea-pig-organ extract on growth of mycobacterium h37 rv. | | 1976 | 828622 |
| [use of the microculture method for assessing the quality of disinfection in tuberculosis]. | | 1976 | 828793 |
| [fractionation of the mixture of volatile with steam components of propolis and the study of their antimicrobial activity]. | | 1976 | 828845 |
| [simultaneous isolation of mycobacterium tuberculosis and mycobacterium tuberculosis var. africanum in tuberculosis patients at the university hospital of dakar]. | | 1976 | 828867 |
| [phenomenon of primary resistance of koch's bacillus: report on cases assembled at the pneumological hospital s. luigi in turin from 1972 to 1975]. | in this work the authors stress the importance reached in recent years by the primary resistance phenomenon in pulmonary consumption, and they explain the results pointed out by the examination of 171 antibiograms effected from 1972 to 1975 on patients with pathological forms ascertained for the first time. they conclude by underlining the reduction of the primary resistance when employing common antibiotics and, on the contrary, its rise with the use of the rifampicin which has recently been in ... | 1976 | 828885 |
| [pharmacological and biochemical research on the antibiotic "substance m"]. | | 1975 | 829023 |
| [considerations on the importance of bacteriology in the current fight against tuberculosis in spain]. | | 1976 | 829173 |
| [research on the immunosuppressive activity of rifampicin]. | the aa. confirm the influence of rifampicin on delayed hypersensitivity phenomena determining its interference on the tuberculin reaction in guinea-pigs sensitized with freund's adjuvant. in this experimental model rifampicin, either administered during the whole period of sensitization or for shorter periods or even only at the moment of challenge, inhibits the delayed hypersensitivity reactions. also in man the evolution of citologic reactions connected with ppd stimulation in tuberculous tube ... | 1976 | 829306 |
| prospective study of the organization and supervision of the bacteriological diagnosis of pulmonary tuberculosis in a case finding network in algeria. | | 1976 | 829481 |
| case-finding in the korean national tuberculosis programme. | | 1976 | 829483 |
| experimental investigations of bacteriological mechanisms in short course chemotherapy. | | 1976 | 829484 |
| inhibitory effect of tuberculo-protein complex, tubercin-3, on three cases of lepromatous leprosy. | | 1976 | 829558 |
| a serodiagnostic test for tuberculosis. | this study describes a simple whole cell agglutination test for tuberculosis in which phenol-killed mycobacterium tuberculosis h37ra is used as the antigen. the test gave positive results in 59 of 63 culture-positive cases of tuberculosis due to m. tuberculosis, and in 4 of 11 culture-positive cases due to other mycobacteria. negative results were recorded in 168 of 171 control subjects. a positive result was one in which a titre of 1/125 or more was recorded. | 1975 | 829830 |
| comparison of chemical and biological properties of water-soluble adjuvants prepared from mycobacterium tuberculosis, mycobacterium bovis and mycobacterium smegmatis. | | 1976 | 829910 |
| synthesis and biological activity of some new furan quaternary salts. | a series of new n-(5-substituted 2-furfuryl)-n,n-dimethyl-n-aryloxyalkyl quaternary ammonium salts relating to general structure iv has been synthesized by reacting 5-substituted 2-(n,n-dimethylaminomethyl)furans iia-d with appropriate aryloxyalkyl bromides iii. the resulting compounds are tested for in vitro antimicrobial activity. a simpler synthesis of 5-nitro-2-(n,n-dimethylaminomethyl)furan (iid) involving the reduction of n,n-dimethyl-5-nitro-2-furamide (ib) with diborane is described. a n ... | 1977 | 833814 |
| isoniazid with corticosteroids in patients infected with mycobacterium tuberculosis. | | 1977 | 837768 |
| penetration of antitubercular drugs in clinical osteoarticular tubercular lesions. | in 79 consecutive cases of skeletal tuberculosis the concentration of streptomycin and ethambutol was analysed. the material for analysis was obtained from the diseased joints of 14 patients and from cold abscesses from spinal or osseous lesions in 65 patients. the concentration of the drugs in the serum and in the tuberculous material was measured 3 hours after the systemic administration of the drugs in therapeutic doses. the concentration was expressed as microgram per ml of the tuberculous m ... | 1977 | 920129 |
| tuberculous meningitis in an urban general hospital. | we analyzed the clinical and laboratory findings of 19 patients with tuberculous meningitis seen between 1966 and 1974 at the henry ford hospital. eighteen patients were adults at the time of diagnosis. in eight patients, the history suggested that the infection with the tubercle bacillus had occurred in the remote past. cerebrospinal fluid analysis was often typical for tuberculous meningitis; stains for mycobacterium tuberculosis were usually negative. of 16 patients who were treated, five die ... | 1977 | 921437 |
| identification of producer and biological activities of new antibiotics, mimosamycin and chlorocarcins. | a strain of streptomyces, no. 314 identified as a streptomyces lavendulae produced under a novel condition of culture, four new antibiotics, mimosamycin and chlorocarcins a, b, and c. among the components of chlorocarcin complex, chlorocarcin a was found to be most biologically active. this antibiotic inhibited the growth of staphylococcus aureus fda 209p and corynebacterium diphtheriae at the concentrations of 0.1 and 0.003 mcg/ml, respectively. chlorocarcin a also exhibited antitumor activity ... | 1976 | 931810 |
| [lung disease due to mycobacteria other than mycobacterium tuberculosis in japanese national chest hospitals. geographic distribution of the prevalence of the mycobacteria and the disease (author'stransl)]. | | 1976 | 933418 |
| antimicrobial agents: synthesis and antimicrobial activity of new aryloxyalkyl esters of p-hydroxybenzoic acid. | several new aryloxyalkyl esters of p-hydroxybenzoic acid were synthesized and screened for in vitro antimicrobial activity. although a few compounds showed low antifungal activity, many possessed appreciable in vitro antibacterial activity. however, none of these compounds was active against mycobacterium tuberculosis (h37rv). | 1976 | 957118 |
| relationship between lipid composition and antibiotic-resistance to isoniazid, streptomycin, p-aminosalicylic acid, ethambutol, rifampicin in mycobacteria. | the content of neutral lipids, peptido-glycolipids and phospholipids, separated by solvent extractions and tlc, was investigated and compared in various strains of mycobacterium tuberculosis and in mycobacterium avium. the examined strains could be divided into two groups: (i) those possessing a stable inh-resistance with a chromosomal location for the resistance genes, in which the content of total lipids and the distribution of lipid subfractions were modified with respect to the control strai ... | 1976 | 962981 |
| surgical complications of cervical and mediastinal tuberculous adenitis in an infant. | an infant whose miliary tuberculosis was resolving after five months of chemotherapy developed a tuberculous cervical lymphatic abscess followed shortly thereafter by life-threatening tracheal compression from enlarged tuberculous mediastinal nodes. both of these complications required surgical drainage. chemotherapy alone may be ineffective in the management of lymphadenitis caused by mycobacterium tuberculosis. | 1976 | 975959 |
| mycobacterium tuberculosis infection in two east african oryxes. | tuberculous lesions were observed at necropsy of 2 east african oryxes (oryx gazella beisa) at a municipal zoological park in jackson, ms. microscopic examination revealed granulomas containing acid-fast bacilli in the lungs and liver of both animals, as well as in the uterus and mediastinal lymph nodes of 1 animal. mycobacterium tuberculosis was isolated from the tissues of both oryxes and from fluid aspirated from the mammary gland of 1 oryx; the organism was pathogenic for guinea pigs but not ... | 1976 | 977460 |
| cell mediated immunity in the chinchilla (chinchilla laniger): in vitro lymphocyte transformation. | the cell mediated immune system of the chinchilla (chinchilla laniger) was examined using both in vivo and in vitro methods. an in vitro lymphocyte transformation microassay was developed utilizing tritiated thymidine incorporation into spleen cells stimulated by the nonspecific mitogen, phytohemagglutinin-m. peak stimulation of blastogenesis occurred between 48 and 72 hours of incubation with 5 x 10(6) cells/ml in 12.5 mul phytohemagglutinin-m/ml. in spleen cell cultures from chinchillas sensit ... | 1976 | 979141 |
| the status of tuberculin skin testing at the pahlavi university medical centre. | thirty-four patients with tuberculosis were skin tested with 5 tuberculin units (tu) of purified protein derivative of mycobacterium tuberculosis (ppd). ppd supplied by park davis and co., detroit, michigan, u.s.a. (ppd-pd) as well as ppd obtained from the razi institute, hessarak, teheran (ppd-ri) were both used for skin testing in each patient. the results indicate that 74-79% of patients with active tuberculosis have positive tuberculin reactions, that ppd-ri is a potent source of tuberculin ... | 1976 | 1004930 |
| a rapid method of disinfecting the bronchofiberscope. | a method of disinfecting the bronchofiberscope that requires 5 minutes was tested against mycobacterium tuberculosis, pseudomonas aeruginosa, serratia marcescens, klebsiella pneumoniae, staphylococcus aureus, candida albicans, influenza virus, and rhinovirus. the bronchofiberscope was contaminated with either sputum or mucin containing the microorganism. disinfection was performed by washing the inner channel and the outer sheath with a hexachlorophene detergent followed by a solution containing ... | 1976 | 1008353 |
| [tests for the evaluation of cellular immunity to mycobacterium tuberculosis (author's transl)]. | | 1976 | 1025582 |
| pulmonary cavitary disease due to mycobacterium tuberculosis in teenagers. | | 1975 | 1079294 |
| [changes in the cytokinetics of mott's cells following sensitization to bcg under conditions of preliminary treatment of rats with soluble antigens of mycobacterium tuberculosis]. | the effect of pretreatment with tuberculins on bcg sensitization of rats was expressed in the transformation of precursors into mott's cells. the tuberculins, particularly the old tuberculin, inhibited the mc-reaction; this seems to be connected with the tolerogenic action of the mycobacterial polysaccharides. an attempt was made to interpret the results from the point of view of the three-component system of the lymphoid cell cooperation during the formation of humoral antibodies, taking into a ... | 1975 | 1083128 |
| secondary immunodeficiency in miliary tuberculosis. | cell-mediated immune response was investigated in fifteen patients with miliary tuberculosis. delayed hypersensitivity skin test with "recall" antigens ppd and sksd was positive in two and one patients respectively. an irritant dose of dncb failed to induce non-specific inflammatory response in the skin of thirteen patients and the same patients also did not develop contact sensitivity to dncb. leucocyte migration test in the presence of mycobacterium tuberculosis was also negative in eight of e ... | 1975 | 1083782 |
| role of t lymphocytes in adjuvant arthritis. i. evidence for the regulatory function of thymus-derived cells in the induction of the disease. | rats of wistar king aptekman (wka) were thymectomized at 4 weeks of age and injected with mycobacterium tuberculosis wax d 6 weeks after the operation to induce adjuvant arthritis. the development of this disease was strikingly enhanced by this treatment. further experiments showed that a 4- to 6-week interval between thymectomy and wax d injection was necessary to show the enhancing effect. such enhancement by thymectomy was also shown in rats of another strain, sprague-dawley (sd). the enhanci ... | 1976 | 1086866 |
| relative immunogenicity of streptomycin-susceptible and -resistant strains of bcg. ii. effect of the route of inoculation on growth and immunogenicity. | normal cd-1 mice were infected intravenously, subcutaneously, or aerogenically with live bacille calmette guerin (bcg) tice or bcg streptomycin resistant (sm-res) and growth of the organisms in the footpad, the draining popliteal lymph node, the blood, lung, liver, and spleen was followed for as long as 50 days. the vaccinated mice were then challenged on day 50 with 10-5 viable mycobacterium tuberculosis erdman organisms introduced intravenously or subcutaneously. the growth of the erdman chall ... | 1975 | 1089372 |
| migration inhibitory factor and type ii interferon in the circulation of mice sensitized with mycobacterial components. | migration inhibitory factor (mif) and type ii interferon were released into the circulation after mice had been sensitized i.v. with a bacillus of calmette and guerin (bcg) cell-wall-in-oil vaccine and then challenged four weeks later with 50 mg old tuberculin. at least two components of bcg, protein (ppd) and lipid (p-3), have been identified which are essential for the type of sensitization in which mediators are released after appropriate challenge. the route of sensitization had a marked eff ... | 1975 | 1090652 |
| qualitative and quantitative thin-layer chromatography of mycolic acids in mycobacterium tuberculosis var. bovis-bcg. | | 1975 | 1097459 |
| [the characteristics of the antibacterial activity of garlic (author's transl)]. | it has been found by cavallito (1944) that garlic (allium sativum l.) has a strong antibacterial activity and the active principle of garlic is named "allicin" and it has been confirmed by stoll et al. (1948) that the allicin is derived from the alliin-alliinase system. nevertheless, one worker in japan (1951) stands on another view point which the effective component of garlic is some sugar-proteim because he could not find alliin in the native garlic. we intend to make sure that the alliin is ... | 1975 | 1099271 |
| factors affecting the immunizing activity of ribosomal fractions isolated from mycobacterium tuberculosis var. bovis strain bcg. | levels of antituberculous immunity similar to those induced by live bcg vaccine were detected in cf1 mice immunized with ribosomal fractions isolated from mycobacterium tuberculosis var. bovis, strain bcg, and challenged 3 weeks later with the virulent h37rv strain of mycobacterium tuberculosis var. hominis. the activity of the crude ribosomal preparations was found to be a function of the immunizing doses and the immunity induced by 1.0-mg doses remained at the same high level after 4 weeks of ... | 1975 | 1104114 |
| a method for estimating the prevalence of tuberculosis infection. | the prevalence of tuberculous infection in a population is generally estimated from calculating the proportion of tested individuals who react with at least 10 mm of induration to 5 tu of ppd-s tuberculin. reactions due to infection with atypical mycobacteria, however, may cause the prevalence to be overestimated. this paper is concerned with an alternative method of estimating the prevalence of infection with mycobacterium tuberculosis. the method utilizes population distributions of reaction s ... | 1975 | 1124761 |
| corynebacterium bovis as a pathogen in rabbits. | a corynebacterium identified as corynebacterium bovis has been isolated from a chronic testicular abscess and the lung of a laboratory rabbit. the strain, on intravenous injection, reproduced a similar disease in the inguinal and vulval region of an experimental rabbit. sera from both animals showed increasing titres of agglutinating antibody for the isolated corynebacterium and for kaolin particles sensitised with the phosphatide antigen of mycobacterium tuberculosis. it is suggested that the p ... | 1975 | 1129540 |
| interpretation of the ppd skin test in bcg-vaccinated children. | skin testing with 5 tuberculin units (tu) of purified protein derivative (ppd) of tuberculin stabilized with polysorbate (tween) 80 was done 3 months and 1 year after immunization with bacille calmette-guérin (bcg) vaccine in two groups of children: one group vaccinated at birth and another group at age 6 years. interpretation of the ppd skin test with 5 tu is possible in children 1 year and older vaccinated with bcg at birth: if the diameter of induration is more than 10 to 12 mm the reaction c ... | 1975 | 1139496 |
| the tuberculin tine and mono-vacc tests in the patient with active tuberculosis. | eighty-four patients with culture-positive mycobacterium tuberculosis infections of the lung were evaluated with the mono-vacc and tine tuberculin skin tests. a previous report indicated that false negative reactions with the tine may occur in up to 6 per cent of patients when it is used as a screening device for tuberculin sensitivity. however, as indicated by this study, it is unlikely that either screening tests would miss active tuberculous infection; no false negatives occurred in the 84 pa ... | 1975 | 1147373 |
| [a new synthesis of cord factor, the toxic glycolipid from mycobacterium tuberculosis. (trehalose and alpha-branched, beta-hydroxylated fatty acid esters]. | | 1975 | 1203907 |
| pericarditis caused by histoplasma capsulatum. | sixteen patients with pericarditis caused by histoplasma capsulatum were studied. fourteen were less than 30 years old, and no patient had an underlying illness or was receiving immunosuppressive therapy. all patients experienced a flu-like prodromal illness lasting from 2 weeks to 4 months. pneumonitis or hilar adenopathy, or both, was found in 12; pleural effusion, uncommon in primary pulmonary histoplasmosis, was found in seven patients. pericardial fluid, pleural fluid and bone marrow cultur ... | 1976 | 1244738 |
| some bacteriologic aspects of the epidemiology of pulmonary and extrapulmonary tuberculosis. | a study was carried out to investigate the drug resistance patterns of the prevalent tubercle bacilli in pulmonary and extrapulmonary tuberculosis in and about the city of lahore, pakistan. this report includes 168 strains of mycobacterium tuberculosis isolated from the same number of pulmonary tuberculosis cases (100 untreated cases, defined as patients either having no history of anti-tuberculous therapy or having had chemotherapy for not more than 10 days; 68 treated, defined as having had ch ... | 1976 | 1247006 |
| investigation on the serum and lung tissue level of rifampicin in man. | after the oral administration of 600 mg rifampicin, we determined the rifampicin level of the lung tissue of 18 operated patients, as well as the rifampicin level of the pleural callus of one patient, that of the pericardial cyst of another, and the serum level of all the 20 patients. the serum level amounted to an average of 6.5 mcg/ml between 2 and 6hours after administration, and to 3.3 mcg/ml between 8 and 9 hours. the lung tissue level amounted to an average of 2.3 mcg/g. the lung rifampic ... | 1976 | 1248917 |
| treatment of anaerobic pulmonary infections; carbenicillin compared to clindamycin and gentamicin. | twenty-three patients with anaerobic infections of the lung were treated with either two antibiotics, clindamycin and gentamicin (11 patients) or with a single antibiotic, carbenicillin (12 patients). cultures were obtained prior to therapy, either by transtracheal needle aspiration (17 patients) or thoracocentesis (six patients). anaerobic bacteria were found in all. fifteen patients had aerobic and facultative bacteria in addition. the anerobic isolates were peptostreptococci (12), peptococci ... | 1976 | 1277892 |
| heterogeneity of monoclonal antibody-reactive epitopes on mycobacterial 30-kilodalton-region proteins and the secreted antigen 85 complex and demonstration of antigen 85b on the mycobacterium leprae cell wall surface. | proteins of the antigen 85 complex in the 30-kda region secreted by live mycobacteria are important in the immune response against mycobacterial infections and may play an important biological role in the host-parasite interaction. in the present study, we have characterized epitopes of the 30-kda-region proteins and the antigen 85 complex by using a panel of 13 monoclonal antibodies (mabs) reacting with these antigens, 6 of which have not been described before. by using five previously characte ... | 1992 | 1280626 |
| different distributions of lung and blood lymphocyte subsets in pediatric aids or tuberculosis. | pulmonary immunity has not been studied in children with acquired immunodeficiency syndrome (aids) or tuberculosis (tb), even though lungs of both children and adults infected with human immunodeficiency virus (hiv-1) or mycobacterium tuberculosis are affected frequently and severely. in the present studies, the distributions of t (cd3+, cd4+, cd8+) and b (cd19+) lymphocytes in bronchoalveolar lavage fluid (balf) and blood of children with aids (n = 28) and children with pulmonary tb (n = 18) we ... | 1992 | 1280936 |
| cd1b restricts the response of human cd4-8- t lymphocytes to a microbial antigen. | molecules encoded by the human cd1 locus on chromosome 1 (ref. 33) are recognized by selected cd4-8- t-cell clones expressing either alpha beta or gamma delta t-cell antigen receptors. the known structural resemblance of cd1 molecules to antigen-presenting molecules encoded by major histocompatibility complex (mhc) genes on human chromosome 6 (refs 3, 4, 34, 35), suggested that cd1 may represent a family of antigen-presenting molecules separate from those encoded in the mhc. here we report that ... | 1992 | 1281285 |
| t cells in the lesion of experimental autoimmune encephalomyelitis. enrichment for reactivities to myelin basic protein and to heat shock proteins. | to characterize the cellular immune response in an autoimmune lesion, we investigated the accumulation of specific t cells in the central nervous system in actively induced experimental autoimmune encephalomyelitis (eae) in lewis rats, using a limiting dilution analysis (lda) assay for t cells that proliferate in response to antigens. lymphocytes isolated from the spinal cord infiltrate were compared with cells from the popliteal lymph nodes with respect to frequency of cells responding to basic ... | 1992 | 1281835 |
| comparison of bis-di-octadecylamide of trehalose dicarboxylic acid (bda.tda) with glycolipid sl-iv as elisa antigens for the serodiagnosis of leprosy. | two glycolipids--one synthetic and non-natural (bda.tda), the other natural and mycobacterium tuberculosis species-specific (sl-iv)--were tested to determine their serological activity in sera obtained from leprosy patients, and to determine their discriminating ability in the detection of disease. the elisa results obtained in the igg antibody class show that both were useful substances capable of detecting multibacillary and paucibacillary disease in about 2 out of 3 leprosy patients. when the ... | 1992 | 1282141 |
| serodiagnostic value of the 19 kilodalton antigen of mycobacterium tuberculosis in indian patients. | previous studies in uk subjects suggested that the 19 kda protein antigen of mycobacterium tuberculosis might be valuable in the serodiagnosis of paucibacillary tuberculosis. in this study, antibody titres for the 19 kda antigen were higher in healthy controls in india than in the uk. consequently, the diagnostic sensitivity of this antigen and its tb23 epitope was negligible in indian patients with tuberculosis. however, a diagnostic sensitivity of 50% was achieved in patients with skin tubercu ... | 1992 | 1283126 |
| severe cutaneous hypersensitivity reactions during treatment of tuberculosis in patients with hiv infection in tanzania. | concurrent infection with hiv-1 and mycobacterium tuberculosis is increasingly common in east africa. in the past, a drug regimen consisting of 2 months of intramuscular streptomycin plus 12 months of isoniazid and thiacetazone has been used in tuberculosis control programs with acceptable efficacy and low incidence of adverse reactions. anecdotal reports of increasing cases of stevens-johnson syndrome prompted a 2 month prospective search for cases of severe cutaneous hypersensitivity reactions ... | 1992 | 1284179 |
| the laboratory diagnosis of mycobacterial disease. | the diagnosis of mycobacterial disease still relies heavily on conventional microscopy and culture techniques. more modern methods, such as the bactec 460 radiometric system and the roche biphasic system, are becoming available but are not yet widely used. non-culture methods eg, using molecular biology techniques or gas liquid chromatography, are being developed but are currently the province of research and reference laboratories. disease caused by species other than mycobacterium tuberculosis ... | 1992 | 1284939 |
| nosocomial transmission of tuberculosis in aids care centres. | outbreaks of tuberculosis in centres for the care of patients with aids, including outbreaks involving drug-resistant strains of mycobacterium tuberculosis, have been reported from a number of countries and present special problems. transmission of infection may be facilitated by procedures commonly used with aids patients, and recognition of the diagnosis in an infectious case may be delayed. although no similar outbreaks have been identified in the united kingdom, it may be timely to review th ... | 1992 | 1285112 |
| chlorpromazine: a drug potentially useful for treating mycobacterial infections. | chlorpromazine (cpz) is one of several phenothiazines known to have antimicrobial properties. it can inhibit mycobacteria, and was reported in the early literature to improve tuberculosis clinically. cpz was tested here for its ability to inhibit the replication of mycobacterium tuberculosis and mycobacterium avium in cultured normal human macrophages, as determined by counts of viable bacteria at 0, 4, and 7 days after bacterial infection of the macrophages. cpz inhibited the intracellular bact ... | 1992 | 1288966 |
| [experimental models of combined tuberculosis-opisthorchiasis pathology]. | an experimental model of the combined course of tuberculosis and opisthorchiasis is presented in the following variants: pulmonary tuberculosis-chronic opisthorchiasis, acute and chronic opisthorchiasis in combination with tuberculosis contamination, bcg and opisthorchiasis. specific changes in the combined pathology are shown which differ from those that accompany each of the nosological forma. data obtained in bacteriologic, parasitologic, immunologic and pathomorphologic studies were used to ... | 1992 | 1289896 |
| nested amplification protocol for the detection of mycobacterium tuberculosis. | several methods for rapid diagnosis of tuberculosis have been devised through dna amplification. however, the chemically strong cell wall of the species, the presumptively low numbers of organisms and their uneven distribution in clinical samples, and the lack of a "gold standard" for diagnosing tuberculosis, have hindered the routine clinical use of this method. in a pediatric patient group, these factors are more perplexing. to circumvent these problems, we made use of nested amplification and ... | 1992 | 1290866 |
| revised case definition and reporting forms for tuberculosis (effective 1 january 1990). | | 1992 | 1291001 |