| relationship of success in classical immunotherapy to the relative immunorejective strength of the tumor. | six tumors of varying immunorejective strengths were used to compare the response of their isogenic hosts to standardized regimens of immunoprophylaxis and immunotherapy. the tumors were generated spontaneously or induced chemically [with 9,10-dimethyl-1,2-benzanthracene (cas: 57-97-6)], virally (with murine leukemia virus), or radiogenically (with strontium-90). the hosts were c57bl/6j or balb/cbyj mice. immunoprophylaxis and immunotherapy were performed with isogenic irradiated tumor cells, wi ... | 1986 | 3020300 |
| the role of superoxide anion and lysosomal enzymes in anti-listerial activity of elicited peritoneal macrophages. | the in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of listeria monocytogenes egd (listeria) by peritoneal macrophages (pm) was investigated. generation of superoxide anion by pm stimulated with phorbol myristate acetate (pma) was significantly increased by intraperitoneal injection of lactobacillus casei yit 9018 (lc9018) or corynebacterium parvum (cp), but not by injection of peptone. however, superoxide anion generation by lc9018-elicited pm stimulated with li ... | 1986 | 3020680 |
| biological activity of pityrosporum. ii. antitumor and immune stimulating effect of pityrosporum in mice. | the antitumor activity of pityrosporum (p. orbiculare, p. ovale, p. pachydermatis, and pityrosporum sp.) on ehrlich ascites carcinomas (eacs) implanted into outbred icr mice was studied. pityrosporum significantly prolonged the survival of mice, regardless of the administration mode. in the case of p. orbiculare, the maximum survival time was 32.3 days on the mean and was obtained by injection ip of 1 mg (dry weight) p. orbiculare for 7 consecutive days following inoculation of the tumor cells. ... | 1986 | 3022057 |
| alveolar lymphocyte proliferation induced by propionibacterium acnes in sarcoidosis patients. | the proliferation of lymphocytes induced by propionibacterium acnes (p. acnes) was measured by the in vitro incorporation of 3h-thymidine. the mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. the proliferation was significantly enhanced in the untreated patients compared to both the treated patients (p less than ... | 1986 | 3024453 |
| the effect of kupffer cell stimulation or depression on the development of liver metastases in the rat. | tumour cells from a squamous carcinoma (approximately 2.5 x 10(5)) were injected intraportally into a syngeneic strain of rats to produce liver metastases 14 days later. kupffer cells were stimulated by corynebacterium parvum (7 mg or 1 mg i.v.) and zymosan (10 mg intraportally). kupffer cell activity was depressed by the administration of silica, gadolinium chloride or human red cells. the animals in each group were sacrificed at 14 days, the livers removed and the number of visible surface met ... | 1986 | 3024833 |
| patterns of failure in patients with resected stage i and ii non-small-cell carcinoma of the lung. the ludwig lung cancer study group. | the pattern of failure was studied in 1012 patients with resected stage i or ii non-small-cell carcinoma of the lung. initial intrathoracic failure (41%) was more common than initial extrathoracic failure (34%) even though a complete resection was the intent in all patients. the most frequent sites of initial failure were the bronchial resection line (16%) and the central nervous system (cns) (15%). the site distribution of initial failure does not appear to depend on tnm stage or pattern of nod ... | 1987 | 3026260 |
| macrophage membrane proteins: possible role in the regulation of priming for enhanced respiratory burst activity. | brief exposure of macrophages to the proteolytic enzymes papain, elastase, or trypsin primed them for enhanced production of superoxide anion (o2-) in response to stimulation by phorbol myristate acetate (pma). priming by trypsin was achieved at 0 degree c, at which temperature trypsin functions as a protease but is not internalized, supporting the concept that protease priming depends on modification of the plasma membrane. analysis of external membrane proteins after radioiodination of intact ... | 1986 | 3026655 |
| macrophage activation in rat models of inflammation and arthritis: determination of markers of stages of activation. | disease-associated alterations in macrophage functions were assessed by investigating the stages of activation of peritoneal macrophages obtained from adjuvant-induced arthritic rats. the stages of activation were established by defining several functional parameters in macrophages obtained from normal, sterile-irritant injected and propionibacterium acnes injected animals. peritoneal macrophages taken from arthritic rats 17 days post adjuvant injection displayed parameters characteristic of act ... | 1986 | 3026656 |
| hepatic reticuloendothelial system activation in autoimmune mice: differences between (nzb x nzw)f1 and mrl-lpr/lpr strains. | 5'-nucleotidase (5'n) activity and ia expression of hepatic nonparenchymal cells (npcs) of the autoimmune (nzb x nzw)f1 and mrl-lpr/lpr and nonautoimmune c3h/fej, dba/2j, and a/j strains were assayed to determine endogenous activation of the hepatic reticuloendothelial system (res). pretreatment of the nonautoimmune strains with corynebacterium parvum resulted in decreases in fc receptor expressor and 5'n and an increase in ia expression of npcs. endogenous hepatic res activation, as measured by ... | 1987 | 3030589 |
| the immunological activities of components isolated from corynebacterium parvum in mice injected with polyoma tumor cells. | the inhibition of polyoma tumor in cba mice after immunization with different fractions of corynebacterium parvum was investigated. treatment with 200 micrograms of polysaccharide from culture filtrate before s.c. inoculation 2 x 10(6) of tumor cells induced antitumor effect in mice. treatment with lower doses (1 microgram or 20 micrograms) after transplantation of tumor cells was not effective. injection of lipopolysaccharide from escherichia coli abolished a positive response on inhibition of ... | 1987 | 3031518 |
| encephalomyocarditis (emc) virus-induced diabetes mellitus prevented by corynebacterium parvum in mice. | corynebacterium parvum prevented the development of encephalomyocarditis virus-induced diabetes in mice, when it was given 3-14 days before the virus infection. this treatment inhibited virus replication in the pancreas of the infected mice at an early stage of the infection. | 1987 | 3032672 |
| methadone vs morphine: comparison of their effect on phagocytic functions. | a comparison of the effects of methadone and morphine on phagocytic physiology was carried out in mice, using a number of tests, to estimate the risk of using methadone in maintenance protocols for opiates addicts. results indicate that methadone, like morphine, reduces (a) r.e.s. activity and (b) pmn superoxide anion production, while unlike morphine it (a) does not produce haematologic changes, (b) does not exacerbate c. albicans infections, (c) does not inhibit phagocytosis and killing by mur ... | 1987 | 3034811 |
| [in vitro activity of an ofloxacin-metronidazole combination against anaerobic bacteria. kinetics of the action of metronidazole against bacteroides fragilis]. | the activity of metronidazole combined with ofloxacin was investigated by the checkerboard method in liquid medium against 60 obligate anaerobes. the bacteriostatic effect of the combination was assessed by calculating the fic index. two metronidazole resistant strains of propionibacterium acnes (mic greater than 32 mg/l) were inhibited by 0.125 mg/l of this former antibiotic in presence of an ofloxacin concentration equal to half the value of the mic. on the 58 other anaerobic strains, the comb ... | 1988 | 3043345 |
| diagnosis and treatment of chronic postoperative bacterial endophthalmitis. | chronic postoperative bacterial endophthalmitis has recently assumed a prominent role in differential diagnosis of inflammation following extracapsular cataract extraction with posterior chamber intraocular lens implantation. the optimal diagnostic and therapeutic approach to this entity has not yet been clearly defined. we present a case of chronic postoperative propionibacterium acnes endophthalmitis in which the diagnosis was made by anterior chamber paracentesis, and topical, periocular, and ... | 1988 | 3050671 |
| differential effect of inflammatory stimuli on murine plasma c4 and factor b concentrations. | the in vivo effects of a variety of inflammatory stimuli on complement c4 and factor b plasma levels have been examined. mrl/++ (h-2k) mice were given intraperitoneal injections of lipopolysaccharide, turpentine, corynebacterium parvum pyridine extract residue or high doses of indomethacin. all of these treatments induced an increase in plasma factor b concentrations, which in the case of c. parvum was dose dependent and persisted for at least 7 days. lipopolysaccharide, turpentine and indometha ... | 1988 | 3052973 |
| differences between beige and bg/+ mice in the disruption of plasma proteinase regulation in the tumor-bearing state or following corynebacterium parvum treatment. evidence for the involvement of polymorphonuclear leukocyte proteinases. | mice bearing the b16 melanoma or treated with corynebacterium parvum develop elevated levels of plasma neutral proteinase activity. similar experiments carried out with c57bl/6-bg/bg (beige) mice, which are genetically deficient in polymorphonuclear neutrophil (pmn) proteinases, revealed that such mice develop significantly diminished elevation in plasma proteinase activity compared to c57bl/6-bg/+ mice. lysates of c. parvum elicited pmn from beige mice contained approximately 80% less neutral p ... | 1988 | 3053356 |
| palmoplantar pustulosis and sternocostoclavicular arthro-osteitis. | seventeen patients with shoulder pain and radiographic involvement of the sternoclavicular or sternocostal joints, or both, are described. eleven of these patients also had palmoplantar pustulosis. histological examination of the joints showed chronic and subacute inflammation, increased osteoblastic activity, and cartilage degeneration. propionibacterium acnes was cultured in tissue samples from seven of the 15 biopsied patients, a finding at variance with those of previous reports. the possibi ... | 1988 | 3058054 |
| [chronic endophthalmitis caused by propionibacterium acnes in a pseudophakic patient]. | this paper reports the case of a chronic endophthalmitis with hypopion produced by propionibacterium acnes (p. a.) in a patient operated on for cataract and implanted with a posterior chamber intraocular lens. this granulomatous uveitis appeared 8 days after surgery and did not heal with a systemic corticoid-antibiotics treatment. the diagnosis was obtained by vitreous analysis. the responsibility of p. a. must be always searched in case of chronic endophthalmitis in pseudophakic patients: a spe ... | 1988 | 3062063 |
| [propionibacterium acnes in the biopsied lymph nodes of sarcoidosis patients demonstrated by an immunofluorescence and immunoperoxidase staining technics]. | | 1988 | 3066938 |
| [preliminary results of studies of the effect of immunostimulation combined with chemotherapy in patients with ovarian cancer]. | | 1988 | 3069616 |
| serotherapy of ovarian cancer. | the development of monoclonal antibodies has permitted the identification of several ovarian-tumor-associated antigens which might serve as targets for serotherapy in vivo. with the exception of antibodies directed against growth factor receptors, unmodified monoclonal reagents must activate complement (c') components or bind effector cells to destroy tumor targets. antibody-dependent cell-mediated cytotoxicity (adcc) may be particularly important for eliminating tumor cells in vivo. a shortage ... | 1988 | 3070370 |
| immunologic control of ovarian cancer. | | 1988 | 3070371 |
| calcium-dependent and -independent tumoricidal activities of polymorphonuclear leukocytes induced by a linear beta-1,3-d-glucan and phorbol myristate acetate in mice. | some antitumor immunomodulators, such as a linear beta-1,3-d-glucan from alcaligenes faecalis var. myxogenes ifo 13140 (tak), induce potent tumoricidal activity of polymorphonuclear leukocytes (pmns). in the present study we investigated the role of calcium on the tumoricidal activity of pmns induced by immunomodulators, especially tak. the calcium chelator ethylene glycol bis(beta-aminoethyl ether)-n,n,n',n'-tetraacetic acid (egta) almost completely inhibited tak-induced pmn cytotoxicity and th ... | 1986 | 3079591 |
| enhancement of hematopoietic response of mice by subcutaneous administration of lactobacillus casei. | mice that had received heat-killed lactobacillus casei (lc 9018) subcutaneously (s.c.) showed enhanced resistance to systemic (i.e., intravenous) infection with listeria monocytogenes, but the antilisterial resistance of mice was less augmented by s.c. administration of propionibacterium acnes ("corynebacterium parvum"). though there was little change in the total number of splenic leukocytes after s.c. administration of lc 9018, the monocyte-macrophage ratio increased after treatment, reaching ... | 1986 | 3082755 |
| [effects of krestin (psk) on drug-metabolizing enzymes with special reference to the activation of ft-207]. | the effects of psk on hepatic drug-metabolizing enzymes were investigated using sarcoma 180-bearing and non-tumor-bearing icr mice. psk, an immunomodulator, has been commonly used in combination with tegafur for post-operative adjuvant chemotherapy. tegafur is a typical masked compound transformed into 5-fu by the hepatic drug-metabolizing enzyme p-450. it has been reported that immunostimulants such as bcg and anaerobic corynebacterium suppress the drug metabolism. psk and propionibacterium acn ... | 1986 | 3090941 |
| modification of the antitumor action of corynebacterium parvum by stress. | social grouping and isolation of mice, in the presence of an acute stressor, were found to differentially affect the antitumor action of the immunological adjuvant corynebacterium parvum. socially grouped dba/2j mice were injected intradermally with p815 mastocytoma ascites cells. half the mice had a threshold dose of c. parvum admixed with the p815 cells. half the mice in each of those conditions were given acute, inescapable electric footshock. in a second experiment, the stressed mice were so ... | 1986 | 3092254 |
| suppression of fibroblast proliferation by activated macrophages: involvement of h2o2 and a non-prostaglandin e product of the cyclooxygenase pathway. | macrophages are considered promoters of fibroblast proliferation; however, suppression by activated macrophages may outweigh this effect. activated murine peritoneal macrophages obtained by in vivo exposure to c. parvum or by in vitro lps-activation of thioglycollate-induced macrophages, were tested for their effect on normal syngeneic dermal fibroblasts. c. parvum-activated macrophages, but not resident peritoneal macrophages suppressed fibroblast proliferation. similarly, macrophages activated ... | 1986 | 3093089 |
| the role of anti-asialo gm1 antibody-sensitive cells in the implementation of tumor-specific t cell-mediated immunity in vivo. | the present study deals with the role of cells sensitive to anti-asialo gm1 antibody treatment in t cell-mediated tumor cell eradication in vivo. rabbit anti-asialo gm1 antiserum was injected into c3h/he mice. this treatment not only resulted in almost complete abrogation of natural killer (nk) cell activity but also produced a potent inhibiting effect on the generation of activated macrophage activity induced by inoculating propionibacterium acnes (p. acnes). such an immunodepressed state laste ... | 1986 | 3093429 |
| immunomodulation with killed propionibacterium acnes in guinea pigs simultaneously vaccinated with brucella abortus strain 19. | immunomodulation with killed propionibacterium acnes was attempted in guinea pigs simultaneously vaccinated with brucella abortus strain 19. two groups, each comprised of 9 guinea pigs, were injected by different routes (s.c. and or i.v.) with 1.4 mg of p. acnes and 5 x 10(8) cfu of b. abortus, s-19, while 3 other groups each received either p. acnes, b. abortus s-19, or saline (s.c.). the antibody titers to b. abortus measured at 6, 10 and 14 weeks after vaccination indicated no significant (p ... | 1986 | 3094237 |
| induction of murine gamma interferon production by lipopolysaccharide and interleukin-2 in propionibacterium acnes-induced peritoneal exudate cells. | lipopolysaccharide (lps) induces high levels of gamma interferon (ifn-gamma) in the circulation of mice pretreated with heat-killed propionibacterium acnes. the following results were obtained in the present study. lps, as well as interleukin-2 (il-2), was also able to induce ifn-gamma in vitro in peritoneal exudate cells (pec) from such mice. splenocytes and lymph node cells from these mice or resident peritoneal cells from control mice produced trace or undetectable amount of ifn-gamma upon ex ... | 1987 | 3100448 |
| differences in tumor necrosis factor productive ability among rabbits. | | 1986 | 3100847 |
| in vitro and in vivo release of cytostatic factors from lactobacillus casei-elicited peritoneal macrophages after stimulation with tumor cells and immunostimulants. | the effect of tumor cells and immunostimulants on the release of cytostatic factors (cf) from lactobacillus casei yit 9018 (lc)-, corynebacterium parvum (cp)- or peptone-elicited peritoneal macrophages (pm) was investigated in vitro and in vivo. significant release of cf into the culture medium from pm elicited with lc was induced by seven of eight mitomycin c-pretreated tumor cell lines and not by normal spleen cells, while no cf was released extracellularly from peptone-elicited pm given the s ... | 1987 | 3102062 |
| induction, maintenance, and reinduction of tumoricidal activity in bone marrow-derived mononuclear phagocytes by corynebacterium parvum. evidence for the involvement of a t cell- and interferon-gamma-independent pathway of macrophage activation. | rat bone marrow-derived mononuclear phagocytes, virtually homogeneous with respect to the cell lineage, do not exhibit spontaneous tumoricidal activity in the resting state. when incubated with macrophage-activating lymphokines, rat recombinant interferon-gamma (ifn), or heat-killed corynebacterium parvum, bone marrow-derived mononuclear phagocytes readily evolve tumoricidal activity. whereas tumoricidal activity induced by lymphokines and/or rat recombinant ifn-gamma is short-lived, that elicit ... | 1987 | 3104463 |
| bmy 28100, a new oral cephalosporin. | bmy 28100, a new oral cephalosporin with a (z)-propenyl side chain at the 3 position and a p-hydroxyphenylglycyl substituent at the 7 position, was evaluated in comparison with cefaclor and cephalexin and, when appropriate, ampicillin and vancomycin. in vitro, bmy 28100 was more active than the reference cephalosporins against streptococci, staphylococcus aureus, staphylococcus epidermidis, listeria monocytogenes, haemophilus influenzae, propionibacterium acnes, clostridium perfringens, and clos ... | 1987 | 3105449 |
| frequency analysis of augmented ctl production associated with corynebacterium parvum-induced tumour regression. | a limiting-dilution frequency assay was employed to estimate the increased production of cytolytic t lymphocytes (ctl) associated with corynebacterium parvum-induced regression of the p815 mastocytoma growing subcutaneously in semisyngeneic mice. it was found that intratumour c. parvum functioned to augment greatly the underlying concomitant production of ctl that occurs normally in response to a progressively growing untreated immunogenic tumour. the lymph node draining a c. parvum-treated tumo ... | 1987 | 3106195 |
| therapeutic effect of cell-wall skeleton of propionibacterium acnes in combination with a monoclonal antibody (c6-1.2) on the lung metastases of lewis lung carcinoma. | the purpose of this study was to determine whether the combination of c6-1.2 monoclonal antibody (moab) (established in our laboratory), which is specifically reactive with lewis lung carcinoma (3ll), and cell-wall skeleton of propionibacterium acnes c7 (p. acnes-cws) would significantly decrease established spontaneous metastases of 3ll. c6-1.2 moab combined with intratumoral (or intralesional) injection of p. acnes-cws, when administered at an early stage of the experiment, showed a significan ... | 1987 | 3112064 |
| the effect of carbon dioxide on the in vitro activity of erythromycin and ru-28965 against anaerobic bacteria. | the in vitro activity of erythromycin and ru-28965 (a novel macrolide antimicrobial with improved pharmacokinetics) was determined against a variety of anaerobic bacteria in anaerobic atmospheres with and without added carbon dioxide. minimum inhibitory concentrations (mic) were determined using an antimicrobial incorporation technique in wilkins-chalgren agar (oxoid, uk) containing saponinlysed horse blood to a final concentration of 10%. the inoculum used was approximately 10(4) colony forming ... | 1987 | 3113907 |
| plasma protein synthesis in experimental cancer compared to paraneoplastic conditions, including monokine administration. | during tumor growth, there are characteristic alterations in the concentration and synthesis of various plasma proteins. the purpose of this study was to evaluate whether these changes are unique to a tumor-bearing state, or rather, they represent a generalized response to a paraneoplastic state mediated by the release of monokines or protein-calorie malnutrition. plasma protein synthesis and concentrations in mice bearing a transplantable fibrosarcoma were compared to animals receiving either a ... | 1987 | 3117356 |
| incomplete surgery, local immunostimulation, and recurrence of some tumour types in dogs and cats. | histologically confirmed inadequate treatment resulted in a lower than expected recurrence percentage in dogs with haemangiopericytoma (38%) and mastocytoma (30%). clinical suspicion of inadequate tumour treatment did not always correlate with the histologically assessed inadequacy, nor with the appearance of local recurrence. local recurrence did not seem to be correlated with histological grade of malignancy and tumour size. local injection of c. parvum vaccine did not result in a lower percen ... | 1987 | 3118558 |
| induction of interleukin 1 secretion and of tumoricidal activity in macrophages are not closely related phenomena. | rat bone marrow-derived mononuclear phagocytes (bmm phi), induced to differentiate in vitro and homogeneous with respect to the cell lineage, were interacted with various macrophage-activating agents. the effect of these agents on the secretion of interleukin 1 (il 1) activity and on the development of tumoricidal capacity was comparatively assessed. the findings show that il 1 secretion is considerably enhanced by macrophage-activating factor and by recombinant interferon-gamma but remained una ... | 1987 | 3119353 |
| a study on the adhesive properties of cor. diphtheriae and cor. parvum in the direct haemagglutination reaction. | the adhesive properties of one cor. parvum and two cor. diphtheriae strains were investigated by means of the direct haemagglutination reaction (har). using a specifically developed har procedure, it was proved beyond doubt that the studied corynebacteria possess adhesive properties apparently associated with the presence of pili (fimbrias) on their surfaces. in addition, a correlation was found between the agglutinating activity of bacteria and the conditions of culture growth. based on the rep ... | 1987 | 3119703 |
| propionibacterium acnes: a neglected head and neck pathogen. | | 1987 | 3120131 |
| cytopathogenic protein in filtrates from cultures of propionibacterium acnes isolated from patients with kawasaki disease. | propionibacterium acnes may have a role in kawasaki disease. filtrates from cultures of p acnes isolated from cervical lymph node biopsy specimens and blood samples from patients with kawasaki disease were studied and compared with samples from control subjects. after inoculation of human embryo liver cells with filtrates from the patients a cytopathogenic effect and vacuolation were seen. a specific cytopathogenic substance was found in only the filtrates of cultures from patients with kawasaki ... | 1987 | 3120957 |
| modulation of beta-galactosidase activity in peritoneal macrophages from c57b1 mice after exposure to proprionibacterium acnes. | peritoneal macrophages (pm luminal diameter) from untreated c57b1 mice contain high levels of beta-galactosidase (beta-gal) and these pm luminal diameter are heterogeneous in their expression of this enzyme. intraperitoneal (i.p.) injection of saline caused a transient depression in the level of enzyme activity in the pm luminal diameter whereas i.p. injection of proprionibacterium acnes (p. acnes) gave rise to a marked decrease of beta-gal activity in these cells. this reduction in enzymatic ac ... | 1987 | 3122521 |
| contribution of the microflora to proteolysis in the human large intestine. | protease activities in human ileal effluent were approximately 20-fold greater than in normal faeces. comparative studies with faeces from a person who did not have a pancreas suggested that a substantial proportion of the proteolytic activity in normal faeces was of bacterial origin. thimerosal, iodoacetate, edta and cysteine significantly inhibited proteolysis in faeces, but not in small intestinal contents, showing that cysteine and metalloproteases were produced by bacteria in the large gut. ... | 1988 | 3127369 |
| antitumor effect of normal intestinal microflora on ehrlich ascites tumor. | in order to investigate the antitumor activity of intestinal microflora, the constitution of normal flora was examined in humans, guinea pigs and mice. it was clarified that eubacterium, bifidobacterium and bacteroides were the predominant bacterial genera in humans. in addition, neither clostridium nor enterobacteriaceae was detected in guinea pigs and neither clostridium nor bifidobacterium was present in mice. total bacterial counts in tumor-bearing mice were reduced in comparison with those ... | 1988 | 3128498 |
| the influence of adjuvant on induction of protective immunity by a non-living vaccine against schistosomiasis. | mice were protected against subsequent infection with schistosoma mansoni by intradermal or s.c. vaccination with killed schistosomula or soluble parasite extracts and bacillus calmette-guérin (bcg). treatment with i.p. immunization was somewhat less effective, whereas i.m. vaccination failed to elicit protective immunity. the level of resistance induced by intradermal immunization was influenced by the strain of bcg used, and isolated bcg cell walls did not reliably substitute for whole bcg org ... | 1988 | 3128608 |
| natural production and release of tumour necrosis factor. | tumour necrosis factor (tnf) was first described as an oncolytic factor found in sera of animals injected (primed) with reticuloendothelial stimulators and subsequently (days later) given lipopolysaccharide (lps). tnf is not found in the serum of 'primed' animals but can be found in animals given lps alone when sensitive assays are employed. tnf appears almost immediately upon lps injection, reaches a maximum from about 1.5-2 hours and disappears rapidly thereafter, and is almost undetectable by ... | 1987 | 3131075 |
| antimicrobial properties of kupffer cells. | to characterize the antimicrobial activities of kupffer cells, i harvested macrophages from livers with a technique involving perfusion with collagenase and dnase. ninety-nine percent of glass-adherent cells had typical macrophage morphology, 99% were esterase positive, and 60% phagocytosed opsonized zymosan when challenged with four particles per macrophage. toxoplasma gondii multiplied within kupffer cells from unmanipulated mice, but multiplication was intermediate between that observed in hi ... | 1988 | 3131244 |
| prosthetic valve endocarditis caused by propionibacterium acnes. | | 1988 | 3132285 |
| protective effects of a leukotriene inhibitor in an experimental massive hepatic cell necrosis model. | when heat-killed propionibacterium acnes was intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide was also intravenously injected, most of them died of massive hepatic cell necrosis. however, when azelastine hydrochloride, a leukotriene antagonist chemically known as 1(2h)-phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1h-azepine-4-yl)-, monohydrochloride, or aa861, 2-(12-hydroxydodeca-5, 10-diynyl)-3,5,6-trimethyl-1, 4-benzoq ... | 1988 | 3136049 |
| alteration of non-specific resistance to infection with listeria monocytogenes. | the experimental infection of murine hosts with listeria monocytogenes is often used as a model for cell-mediated immunity. however, the natural immunity or non-specific resistance to listeriosis can be influenced by the parasite itself and also by a wide array of endogenous and exogenous host factors. the most important host factor in inbred mouse strains is their genetically determined susceptibility or resistance to listeria monocytogenes. secondly, the age of the mice is crucial for the outc ... | 1988 | 3138182 |
| effect of psk, a protein-bound polysaccharide from coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice. | the effects of psk and propionibacterium acnes (anaerobic corynebacterium) on hepatic drug-metabolizing enzymes were studied using sarcoma-180 bearing and non-tumor bearing mice. psk had no influence on aminopyrine n-demethylase and aniline hydroxylase activities, cytochrome p-450 concentration in hepatic microsomes, and the reductase activity of cytochrome c in normal mice. the content of cytochrome p-450 was not significantly reduced in s-180 bearing mice. on the other hand, p. acnes administr ... | 1988 | 3139576 |
| comparison of efficacy of mitomycin-c and corynebacterium parvum in the management of malignant pleural effusion. | | 1988 | 3150706 |
| polyacrylamide gel electrophoresis (page) of whole-cell proteins of cutaneous propionibacterium species. | polyacrylamide gel electrophoresis (page) was applied to the study of whole-cell proteins of cutaneous propionibacteria in an attempt to characterise possible protein patterns that may be typical for strains isolated from acne skin. isolates were obtained from the faces of 33 individuals aged 7-16 years. some of these subjects had apparently normal healthy skin, whereas others had acne vulgaris of varying severity. twenty-five facial isolates of propionibacterium acnes and eight of p. granulosum ... | 1985 | 3155801 |
| blepharitis associated with acne rosacea and seborrheic dermatitis. | | 1985 | 3156100 |
| induction of tumoricidal activity of polymorphonuclear leukocytes by a linear beta-1,3-d-glucan and other immunomodulators in murine cells. | the cytotoxic activity of polymorphonuclear leukocytes (pmn) against tumor cells induced in vitro by antitumor immunomodulators was examined by a 51cr release cytotoxicity assay. among 28 immunomodulators and other agents thus far tested, only beta-1,3-glucan from alcaligenes faecalis var. myxogenes ifo 13140, bacillus calmette-guérin, propionibacterium acnes, zymosan a, and nocardia cell wall skeleton were found to cause induction. the cytotoxic activity of pmn with the beta-1,3-glucan was very ... | 1985 | 3156669 |
| [effects on the lymphreticular system and inhibition of liver microsomaal cytochrome p-450 in mice administered priopionibacterium acnes (corynebacterium parvum) bacterin]. | | 1985 | 3157461 |
| acne fulminans with osteolytic lesions. | multifocal lytic bone lesions were found in a patient with a severe form of acne. the clinical presentation was suggestive of "acne fulminans." propionibacterium acnes was isolated from a subculture of bone tissue. the association of acne fulminans and osteolytic lesions is rare and the pathophysiology is unknown. however, the use of corticosteroids for systemic effect combined with local measures seems to give excellent treatment results. | 1985 | 3158287 |
| antibody titers to propionibacterium acnes cell wall carbohydrate in nodulocystic acne patients. | in order to determine which structures in propionibacterium acnes are most antigenic to severe acne patients, we studied the specificity of anti-p. acnes antibodies in serum from 15 nodulocystic acne patients and 5 normals. complement fixation titers to p. acnes cell wall fractions were determined using guinea pig serum as a complement source. the mean titers of patients and normals to whole cells were 39.6 and 3 (p less than 0.1); to crude cell wall, 138 and 8 (p less than 0.01); and to protein ... | 1985 | 3158714 |
| isolation of an acidic polysaccharide antigen from propionibacterium acnes. | an acidic polysaccharide antigen is released from propionibacterium acnes i and ii during growth. the molecular weight of the antigen was heterogeneous and when fractionated on a sepharose cl-6b column, the antigen was detected at kav values of between 0.1 and 1.0. the pi of the antigen was below 3.5. rabbit antiserum raised against purified acidic-polysaccharide agglutinated p. acnes showing that the polysaccharide was a surface antigen. human antibodies towards whole p. acnes-ii organisms were ... | 1985 | 3160311 |
| inhibition of bacterial translocation from the gastrointestinal tract by nonspecific immunostimulation. | | 1985 | 3161085 |
| cytotoxic activity of propionibacterium acnes and other skin organisms. | culture supernatants from four species of skin micro-organisms were tested against vero (monkey kidney cells) and skin fibroblasts for cytotoxic activity. cytotoxic activity was produced by the three species of propionibacterium tested (p. acnes, p. avidum and p. granulosum), and this activity was highest when cultures were grown in the presence of glucose. in contrast, staphylococcus epidermidis was devoid of cytotoxic activity whether grown in the presence of glucose or not. the agent responsi ... | 1985 | 3161535 |
| acne-like chronic inflammatory activity of propionibacterium acnes preparations in an animal model: correlation with ability to stimulate the reticuloendothelial system. | the ability of strains and fractions of killed propionibacteria suspensions to produce chronic rat ear inflammation after intradermal injection of 70-micrograms aliquots was highly correlated with production of splenomegaly in the mouse after i.p. injection of 1.4 mg propionibacterium acnes strains cn 6134, vpi 0009, atcc 11828, and ucla sc and n1 produced a 2- to 3-fold increase in rat ear thickness and a 5- to 7-fold increase in mouse spleen weight 15 days post injection. in contrast p. granul ... | 1985 | 3161957 |
| [the use of corynebacterium parvum in pleurodesis]. | | 1988 | 3168834 |
| ocular dangers in the garden. a new menace--nylon line lawn trimmers. | nylon line lawn trimmers represent a source of potentially devastating ocular trauma. five cases of ocular trauma associated with the use of line trimmers are reported. these case reports document new mechanisms and circumstances of injury, including trauma from debris other than nylon line fragments and injury to bystanders. furthermore, injuries are often serious, with two of these patients requiring an evisceration or enucleation after endophthalmitis developed. in one patient, six different ... | 1988 | 3174040 |
| effects of the polysaccharide chain of lipopolysaccharide in an experimental massive hepatic cell necrosis model. | when small amounts (1 microgram) of lipopolysaccharide (lps) purified from salmonella minnesota (sm) wild, sm r60 and sm r345 were intravenously injected into mice 7 days after heat-killed propionibacterium acnes was intravenously injected, massive hepatic cell necrosis was induced and most of the mice died within 24 hours. however, when lps from sm r345 treated galactosidase, sm r5 and sm r7 and lipid a from sm r595 were administered, the survival rate was much higher and no histological change ... | 1988 | 3178810 |
| effects of the polysaccharide chain of lipopolysaccharide in an experimental massive hepatic cell necrosis model in the mice. | when a small amount (1 microgram) of lipopolysaccharide (lps) purified from salmonella minnesota wild, salmonella minnesota r60, and salmonella minnesota r345 was intravenously injected into mice 7 days after heat-killed propionibacterium acnes was intravenously injected, massive hepatic cell necrosis was induced and most of the mice died within 24 hours. however, when lps from salmonella minnesota r5 and salmonella minnesota r7 and lipid a from salmonella minnesota r595 were administered, the s ... | 1988 | 3181665 |
| bacteriological findings of acute maxillary sinusitis in young adults. | bacteriological findings in 339 sinus secretions obtained by puncture were investigated in 238 young adult patients with acute maxillary sinusitis. aerobic and anaerobic cultures were performed immediately. a total of 76% of the secretions were positive. the most common pathogens isolated were haemophilus influenzae (50%), streptococcus pneumoniae (19%), streptococcus pyogenes (5%), and branhamella catarrhalis (2%). coagulase-negative staphylococci and staphylococcus aureus were isolated in 8 an ... | 1988 | 3182986 |
| corynebacterium parvum as palliative treatment in malignant ascites. | | 1988 | 3183831 |
| role of anaerobic bacteria in aortofemoral graft infection. | a 10-year review of specimens of aortofemoral graft infection sent to the microbiology laboratory for cultures of anaerobic bacteria revealed the presence of these organisms in 13 of 16 specimens. nineteen organisms (1.5 per patient) were isolated: 16 anaerobes and 3 aerobes. the predominant bacteria were anaerobic gram-positive cocci (six isolates), propionibacterium acnes (five), and bacteroides fragilis group (four). polymicrobial infection was present in three patients, all with decubitus ul ... | 1988 | 3187899 |
| tumor necrosis factor/cachectin. induction of hemorrhagic necrosis in normal tissue requires the fifth component of complement (c5). | tnf induces hemorrhagic necrosis (hn) when injected into skin exposed to bacterial agents but not when injected into normal skin. in this paper, we present several lines of evidence suggesting that tnf requires the fifth component of complement (c5) to induce hn in skin exposed to bacteria. first, mouse strains that do not have c5 did not develop hn after injection of tnf and bacteria into skin. second, plasma from c5-sufficient mice could correct the defect in these c5-deficient mice. third, he ... | 1988 | 3199066 |
| in vitro activity of flomoxef compared to moxalactam, cefoxitin, cefotaxime, and clindamycin against anaerobes. | to assess the in vitro activity of flomoxef (6315-s), moxalactam, cefoxitin, cefotaxime, and clindamycin against anaerobes 197 clinical isolates (27 bacteroides fragilis, 42 b. thetaiotaomicron, 10 b. vulgatus, 7 b. ovatus, 6 b. uniformis, 6 b. distasonis, 7 bacteroides melaninogenicus group, 11 bacteroides oralis group, 21 clostridium difficile, 7 c. perfringens, 3 c. sporogenes, 3 clostridium spp., 33 propionibacterium acnes, 14 peptococcaceae) were studied by means of agar dilution tests. the ... | 1988 | 3214438 |
| age and lpr dependent induction of increased sensitivity to the toxic effects of lipopolysaccharide and indomethacin in mrl mice: evidence for res activation during disease progression. | injection of 4.5-6 month old female mrl-lpr/lpr mice with 200-250 micrograms lipopolysaccharide led to the death of the animals within two days. treatment of age matched female control mice (mrl-+/+) or young (3 month) mrl-lpr/lpr mice did not lead to similar toxicity. however, pretreatment of young mice with the pyridine extract of residue of corynebacterium parvum (alternatively designated propionibacterium acnes) prior to lipopolysaccharide injection, led to the rapid death of 100% of the mic ... | 1988 | 3230580 |
| properties and characteristics of a bacteriocin-like substance produced by propionibacterium acnes isolated from dental plaque. | a cell-associated bacteriocinlike substance with an approximate molecular weight of 78,000 was isolated from an oral isolate of propionibacterium acnes. the substance was bacteriostatic and was active against both gram-positive and gram-negative anaerobes. lysozyme inhibited the activity of the bacteriocinlike substance at low ionic strength. | 1988 | 3233559 |
| characteristics of the hepatocytotoxic factor in mice with experimentally-induced massive hepatic cell necrosis. | | 1988 | 3248030 |
| endophthalmitis following nd:yag laser posterior capsulotomy. | we report the development of propionibacterium acnes endophthalmitis following nd:yag laser posterior capsulotomy. the patient previously underwent uncomplicated extracapsular cataract extraction with intraocular lens insertion and was free of inflammation prior to laser capsulotomy. diagnostic vitrectomy and aqueous tap were performed, and p. acnes was isolated from the aqueous in thiol broth media after nine days of incubation under anaerobic conditions. the patient was managed with topical an ... | 1988 | 3258419 |
| propionibacterium acnes. | | 1988 | 3261615 |
| eradication of syngeneic tumor (meth a fibrosarcoma) from mice by adoptive immunotherapy of immunized spleen cells induced by corynebacterium parvum-pyridine extract residue. | eradication of immunologically-syngeneic tumors was achieved by adoptive chemotherapy using effector cells induced by corynebacterium parvum-pyridine extract residue (cp-per). a mixture of 2 x 10(6) meth a cells and 0.1 mg cp-per was subcutaneously inoculated into the back of donor balb/c mice, with the result that their spleen cells showed an antitumor effect 10 to 13 days after the inoculation. these cells were used as immune cells. recipient mice were inoculated with 1 x 10(6) meth a cells, a ... | 1988 | 3266420 |
| [in vitro experiments with respect to the invasiveness of propionibacterium acnes into human teeth]. | | 1988 | 3269190 |
| tissue localization and kinetics of pit cells or large granule lymphocytes in the liver of rats treated with biological response modifiers. | the numbers of kupffer cells (macrophages) and pit cells (large granular lymphocytes) were counted by light and electron microscopy in perfusion-fixed liver sinusoids. after a single intravenous injection of the biological response modifiers zymosan, propionibacterium acnes and ok-432, a 4- to 6-fold increase in the number of pit cells and a 2- to 4-fold increase in the number of kupffer cells were observed within a period of 4 to 7 days. the mechanisms of the pit cell accumulation were further ... | 1988 | 3276590 |
| antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma. | the antitumour effects of lipoteichoic acids (lta) extracted from streptococcus pyogenes were studied in comparison with other streptococcal cellular components. lta suppressed the tumour growth of both solid- and ascites-type meth a fibrosarcoma as did the whole cells of s. pyogenes (ok-432). no other cellular components, such as cell wall peptidoglycan, group-specific c-carbohydrate or type-specific m protein, suppressed the growth of meth a. lta, but not the other cellular components, induced ... | 1988 | 3279996 |
| phototoxicity of skin microorganisms tested with a new model. | a new standardized method for testing phototoxicity of chemicals against microorganisms is described. the inoculum size of the microorganism, application of test chemicals, prediffusion time, incubation time and incubation period are defined. staphylococcus aureus, s. epidermidis, candida albicans, and pityrosporum orbiculare were studied. both 8-methoxypsoralen and trimethylpsoralen were phototoxic against all microorganisms tested, while tetracycline and doxycycline were not phototoxic. c. alb ... | 1988 | 3288127 |
| treatment of malignant pleural effusions with intracavitary corynebacterium parvum. | fifty-three cases of metastatic pleural effusion (30 haemorragic and 23 serofibrinous) were treated with 4 mg of corynebacterium parvum (cp) injected weekly into the pleural cavity after total thoracentesis. of the 53 effusions, 24 were metastases from lung cancer and 29 from breast cancer. complete response (cr) was assessed as total resolution of pleural effusion after explorative thoracentesis. the results were as follows: 15 cr after two injections of cp, 30 cr after three, and 5 cr after th ... | 1988 | 3293763 |
| corynebacterium parvum, but not bcg, induces elevations in plasma proteinase activity similar to those observed in tumor-bearing mice. | intraperitoneal administration of corynebacterium parvum to balb/c, c57bl/6 or c3h/hej mice lead to the induction of elevated levels of neutral proteinase activity (125i-caseinolytic activity) similar to those observed previously in animals bearing the bcl1 leukemia or the b16-f10 melanoma. enhanced activity reached a peak at 7-14 days postinjection of the c. parvum and then gradually returned to normal levels by 20-25 days postinjection. increased plasma proteinase activity could be induced by ... | 1987 | 3297943 |
| effects of radiation and other influences on chemical lymphomagenesis. | methylnitrosourea (mnu) or butylnitrosourea (bnu) was used to induce t cell lymphomas (thymomas) in bdf1 mice. in addition to the chemical, x-rays in various dose schedules were applied. an effect of the irradiation (shortening of the latency period) was seen with 12 x 0.25 gy in protocols with a prolonged median induction time in the controls as a result of a dose reduction of the chemical (median induction time 27-36 weeks instead of 16-18 weeks under 'optimal' conditions using 50 mg kg-1 of m ... | 1987 | 3298104 |
| susceptibility in vitro of gram-positive aerobe and anaerobe bacteria to ofloxacin. | ofloxacin is a new fluoroquinolone derivative active against gram-positive and gram-negative bacteria including obligate anaerobes. in this study the in vitro activity of ofloxacin was evaluated against 325 gram-positive organisms freshly isolated from clinical specimens, in comparison with that of ampicillin, erythromycin, clindamycin and ceftazidime. susceptibility tests indicated that the mic90 was 2 mg/l (range 0.25-2) against both methicillin-susceptible (ms) and methicillin-resistant (mr) ... | 1987 | 3304918 |
| fate of legionella pneumophila philadelphia-1 strain in resident, elicited, activated, and immune peritoneal macrophages of guinea pigs. | legionella pneumophila is known to grow intracellularly in resident peritoneal macrophages of guinea pigs. the present study was done to determine what kinds of macrophage stimulants are able to activate guinea pig macrophages to inhibit intracellular growth of the organism. peritoneal macrophages were harvested from healthy guinea pigs, from guinea pigs injected intraperitoneally with proteose peptone (pp) or thioglycolate medium, from guinea pigs injected intraperitoneally with live mycobacter ... | 1987 | 3308708 |
| regulatory interactions between macrophages and t cells in mycobacterium lepraemurium-specific t-cell activation. | the antigen-specific proliferative response of draining lymph node cells was found to follow a similar pattern in both c57bl and balb/c mice following subcutaneous infection with mycobacterium lepraemurium (mlm), although the two strains differed in their ability to control bacterial growth at the site of infection. the proliferative response, which was maximal 1-2 weeks postinfection, was t-cell dependent as it was abrogated with anti-thy 1.2 + c treatment. the response was also abrogated by pr ... | 1987 | 3319191 |
| steroids and tuftsin fail to prevent the induction of altered plasma proteinase homeostasis in mice bearing the b16 melanoma or treated with c. parvum. | the effects of tuftsin and steroids (methyl prednisolone) on the induction of disrupted plasma proteinase regulation in mice bearing the b16 melanoma or treated with corynebacterium parvum was investigated. tuftsin treatment inhibited tumor progression only if treatment was started at the time of tumor transplantation. however, tuftsin inhibited the development of splenomegaly in mice with established tumors. in contrast, tuftsin did not influence either the induction of elevated plasma proteina ... | 1987 | 3319918 |
| immune complex study of biopsy specimens from kawasaki disease patients. | | 1987 | 3321077 |
| changes in expression of bacterial surface antigens induced by antibiotics and their influence on host defenses. | concomitant with the discovery that a number of antibiotics were able to induce profound morphological changes (increased septation, thickened walls, filamentation) at low concentrations their ability to inhibit bacterial protein/polysaccharide synthesis was determined. in particular toxin and extracellular enzyme biosynthesis could be repressed by the lincosamines, fusidic acid, erythromycin and streptomycin in staphylococcus aureus, streptococcus pyogenes, propionibacterium acnes, pseudomonas ... | 1987 | 3325899 |
| prevention of peroral and congenital acquisition of toxoplasma gondii by antibody and activated macrophages. | intramuscular administration of toxoplasma gondii lysate antigens to mice produced titers of t. gondii-specific antibody (measured by sabin-feldman dye test) greater than or equal to 1:1,024 in their sera. intravenous administration of heat-killed propionibacterium acnes to mice produced peritoneal macrophages with enhanced microbicidal capacity against t. gondii. mice with high antibody titers or activated peritoneal macrophages or both had reduced numbers of toxoplasma cysts in their brains 30 ... | 1988 | 3335411 |
| studies on the endogenous flora of the human breast. | identification of the endogenous microbiological flora of the human breast and its role in breast infections following subglandular augmentation or reduction mammaplasty was undertaken. a total of 231 cultures were performed on 59 breasts in 30 patients. patients were followed for 12 months. no fungus was cultured from any specimen. of the breasts cultured 53% were positive for coagulase-negative staphylococcus. other aerobes found included diphtheroids, lactobacillus, d-enterococcus, micrococcu ... | 1988 | 3341714 |
| experimental immunological intrahepatic cholestasis model. | heat-killed propionibacterium acnes (p. acnes) was intravenously injected into tuberculin-sensitized guinea pigs, and 7 days later, purified protein derivative (ppd) was also injected intravenously resulting in marked reductions in bile flow and bile acid excretion. serum levels of bile acids and cholesterol were increased, and the activities of alkaline phosphatase (alk-p) and leucine aminopeptidase (lap) were also elevated. histological examination revealed dilatation of bile canaliculi and di ... | 1988 | 3350277 |
| aerobic and anaerobic bacteriology of purulent nasopharyngitis in children. | cultures of aerobic and anaerobic bacteria were obtained from the inferior nasal meatus of 25 children with purulent nasopharyngitis and from 25 controls. microorganisms were isolated from all specimens. a total of 98 isolates (3.9 per patient), 45 aerobes (1.8 per patient) and 53 anaerobes (2.1 per patient), were isolated in patients with purulent nasopharyngitis. seventy-three isolates (2.9 per patient), 47 aerobes (1.9 per patient) and 26 anaerobes (1.0 per patient) were found in the controls ... | 1988 | 3356794 |
| propionibacterium acnes lens abscess after traumatic implantation of intralenticular cilia. | | 1988 | 3358438 |
| correction of defective tumoricidal activity of macrophages from a/j mice by liposomal immunomodulators. | the ability of liposomal immunomodulators to restore abnormal macrophage tumoricidal activity has been studied. macrophages from a/j mice have impaired responses in vitro to macrophage activating factor, gamma-interferon, n-acetylmuramyl-l-alanyl-d-isoglutamine (mdp) or lipopolysaccharide when compared with macrophages from normoresponsive c57bl/6j mice. liposomes containing a lipophilic muramyl dipeptide mdp-glyceroyl dipalmitate, macrophage activating factor or gamma-interferon restored tumori ... | 1988 | 3360595 |
| neutrophil involvement in effects of diethylstilbestrol and strontium 89 on macrophage activation by propionibacterium acnes. | we have recently demonstrated that diethylstilbestrol (des) significantly suppresses macrophage (m phi) activation by propionibacterium acnes. because the initial activation of m phi by p. acnes appears to involve the close interaction of the killed bacteria with inflammatory neutrophils (pmn) and resident m phi in the peritoneal cavity, we investigated whether the des inhibition of m phi activation was associated with inhibition of the pmn response. our data demonstrate that treatment of mice w ... | 1988 | 3366512 |
| susceptibility of anaerobic bacteria to antimicrobial agents. | the antimicrobial susceptibility of 1,117 clinical isolates of anaerobic bacteria was determined by the agar dilution technique. metronidazole was the most active agent; only propionibacterium acnes and actinomyces sp. isolates were resistant. clindamycin and chloramphenical were the next most effective agents. beta-lactam antibiotics, with the exception of penicillin, were active against most anaerobes other than the bacteroides fragilis group. at a breakpoint of 8 mg/l, 25% of fusobacterium sp ... | 1988 | 3374973 |