| design, synthesis and in vitro bactericidal/fungicidal screening of some vanadyl(iv)complexes with mono- and di-substituted ons donor triazoles. | a new series of anti-bacterial and anti-fungal mono- and di-substituted triazoles (l(1))-(l(6)) have been synthesized and characterized on the basis of their physical, spectral and analytical data. the ligands (l(1))-(l(6)) on reaction with vanadyl(iv) sulphate led to the formation of vanadyl(iv) metal complexes (1)-(4). the structure of the complexes has been established on the basis of their physical, spectral and elemental analyses data. the synthesized ligands and their vanadyl(iv) complexes ... | 2015 | 25716124 |
| antifungal and cytotoxic activities of nannorrhops ritchiana roots extract. | this atudy was designed to evaluate the antifungal and cytotoxic activities of the nannorrhops ritchiana (mazari palm) 80% methanol extract (nr-m) and its four crude extracts i.e., petroleum ether (nr-a), dichloromethane (nr-b), ethyl acetate (nr-c) and butanol (nr-d). the antifungal activity was determined by agar tube dilution method against nine fungal strains; aspergillus flavus, trichophyton longifusis, trichophyton mentagrophytes, aspergillus flavus and microsporum canis were susceptible t ... | 2014 | 25362807 |
| metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity. | a series of three bioactive thiourea (carboxamide) derivatives, n-(dipropylcarbamothioyl)-thiophene-2-carboxamide (l(1)), n-(dipropylcarbamothioyl)-5-methylthiophene-2-carboxamide (l(2)) and 5-bromo-n-(dipropylcarbamothioyl)furan-2-carboxamide (l(3)) and their cobalt(ii), copper(ii), nickel(ii) and zinc(ii) complexes (1)-(12) have been synthesized and characterized by their ir,(1)h-nmr spectroscopy, mass spectrometry and elemental analysis data. the crystal structure of one of the ligand, n-(dip ... | 2014 | 23914928 |
| metal based new triazoles: their synthesis, characterization and antibacterial/antifungal activities. | a series of new triazoles and their oxovanadium(iv) complexes have been synthesized, characterized and evaluated for antibacterial/antifungal properties. the new schiff bases ligands (l(1))-(l(5)) were prepared by the condensation reaction of 3,5-diamino-1,2,4-triazole with 2-hydroxy-1-naphthaldehyde, pyrrole-2-carboxaldehyde, pyridine-2-carboxaldehyde, 2-acetyl pyridine and 2-methoxy benzaldehyde. the structures of the ligands have been established on the basis of their physical, spectral (ir, ... | 2012 | 22982389 |
| isolation of the volatile fraction from apium graveolens l. (apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity. | apium graveolens l. (wild celery), belonging to the family of apiaceae, is a scaposus hemicryptophyte. instead, the cultivate plant is an annual or biennial herb widely used as a spice and seasoning in food. a broad range of biological activities have been attributed to a. graveolens. these include antimicrobial activity, larvicidal activity, hepatoprotective activity, nematicidal and mosquito repellent potential and antihyperlipidaemic properties.in this study, the authors compare the compositi ... | 2013 | 22974401 |
| essential oil of juniperus communis subsp. alpina (suter) čelak needles: chemical composition, antifungal activity and cytotoxicity. | essential oils are known to possess antimicrobial activity against a wide spectrum of bacteria and fungi. in the present work the composition and the antifungal activity of the oils of juniperus communis subsp. alpina (suter) čelak were evaluated. moreover, the skin cytotoxicity, at concentrations showing significant antifungal activity, was also evaluated. the oils were isolated by hydrodistillation and analysed by gas chromatography and gas chromatography-mass spectrometry. minimal inhibitory ... | 2012 | 22294341 |
| nimesulide inhibits pathogenic fungi: pge2-dependent mechanisms. | certain non-steroidal anti-inflammatory drugs can inhibit fungal growth, fungal prostaglandin e2 production, and enzyme activation. this study aims to investigate the antifungal effect of nimesulide against pathogenic filamentous fungi and yeast. the experiments detailed below were also designed to investigate whether the action is dependent on e2 fungal prostaglandins. our data showed that nimesulide exhibited potent antifungal activity, mainly against trichophyton mentagrophytes (atcc 9533) an ... | 2017 | 27866353 |
| antimicrobial activity of new 2-thioxo-benzo[g]quinazolin-4(3h)-one derivatives. | the antimicrobial activity of a synthesized series of 28 2-thioxo-benzo[g]quinazolin-4(3h)-one derivatives was evaluated in vitro against five gram-positive bacteria, including bacillus subtilis, enterococcus faecalis, staphylococcus aureus, staphylococcus epidermidis and streptococcus pyogenes. the antibacterial activity was extended to include five gram-negative bacteria: pseudomonas aeruginosa, escherichia coli, proteus mirabilis, klebsiella oxytoca and enterobacter cloacae. furthermore, the ... | 2016 | 27306606 |
| an epidemiological study of animals dermatomycoses in iran. | to determine the fungal species isolated from skin lesions of different animals suspected of having dermatomycoses and their prevalence in different regions of iran. | 2016 | 27180290 |
| antimicrobial activity of synthesized 2-methylthiobenzo[g][1,2,4]- triazolo[1,5-a]quinazoline derivatives. | the present study was carried out to evaluate the antimicrobial activity of a synthesized 2-methylthio-benzo[g][1,2,4]triazolo[1,5- a]quinazoline series. the compounds (1-21) were tested against a variety of gram-positive bacterial species including bacillus subtilis (rcmb 01001 69-3), enterococcus faecalis (rcmb 0100154-2), staphylococcus aureus (rcmb 0100183-9), staphylococcus epidermidis (rcmb 0100183-9) and streptococcus pyogenes (rcmb 0100172-5). in addition, gram-negative bacteria were als ... | 2016 | 27140181 |
| synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates. | a series of new thiophene-based guanylhydrazones (iminoguanidines) were synthesized in high yields using a straightforward two-step procedure. the antifungal activity of compounds was evaluated against a wide range of medicaly important fungal strains including yeasts, molds, and dermatophytes in comparison to clinically used drug voriconazole. cytotoxic properties of compounds were also determined using human lung fibroblast cell line and hemolysis assay. all guanylhydrazones showed significant ... | 2016 | 26867487 |
| in vitro antifungal activity of some traditional persian medicinal plants on pathogenic fungi. | to investigate the antifungal activities of the extracts and sub-fractions of phlomis olivieri, verbascum speciosum, sambucus ebulus and erigeron hyrcanicus, four persian medicinal plants used in iranian folk medicine. | 2015 | 26129901 |
| balticidins a-d, antifungal hassallidin-like lipopeptides from the baltic sea cyanobacterium anabaena cylindrica bio33. | balticidins a-d (1-4), four new antifungal lipopeptides, were isolated from the laboratory-cultivated cyanobacterium anabaena cylindrica strain bio33 isolated from a water sample collected from the baltic sea, rügen island, germany. fractionation of the 50% aqueous meoh extract was performed by bioassay-guided silica gel column chromatography followed by spe and repeated reversed-phase hplc. the main fraction containing the compounds exhibited a strong and specific antifungal activity with inhib ... | 2014 | 24937366 |
| pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a microsporum canis dermatitis model in guinea pigs. | pyrrolo[1,2-α][1,4]benzodiazepines (pbds) have been described as a novel class of antifungal compounds with activity against dermatophytes and aspergillus fumigatus. the initial structure-activity relationship showed that compounds with a chlorine substitution at position 7 have a higher activity compared with regioisomers or other substituents. | 2014 | 24535279 |
| czech ethanol-free propolis extract displays inhibitory activity against a broad spectrum of bacterial and fungal pathogens. | propolis acts primarily as a biocide against invasive bacteria and fungi in the hive, suggesting its potential for industrial applications. in food application, propolis is considered as a chemical preservative in meat products, extending shelf life of frozen meat and other food. the mechanism of action is still unclear due to the synergy of multiple compounds contained in propolis and due to parallel targeting of multiple pathways within each affected organism. here, we examined the antimicrobi ... | 2013 | 23915150 |
| antifungal activity of lactobacillus against microsporum canis, microsporum gypseum and epidermophyton floccosum. | a total of 220 lactic acid bacteria isolates were screened for antifungal activity using aspergillus fumigatus and aspergillus niger as the target strains. four lactobacillus strains exhibited strong inhibitory activity on agar surfaces. all four were also identified as having strong inhibitory activity against the human pathogenic fungi microsporum canis, microsporum gypseum and epidermophyton floccosum. one of the four lactobacilli, namely lb. reuteri ee1p exhibited the most inhibition against ... | 2017 | 22539027 |
| antifungal activity of andrographis paniculata extracts and active principles against skin pathogenic fungal strains in vitro. | andrographis paniculata nees. (acanthaceae) is an annual herbaceous plant widely cultivated in southern asia, china, and europe. it is used in the treatment of skin infections in india, china, and malaysia by folk medicine practitioners. | 2012 | 22587518 |
| molecular identification of fungal pathogens in nodular skin lesions of cats. | in a retrospective study, we investigated 52 formalin-fixed, paraffin-embedded (ffpe) samples from cats with histologically confirmed cutaneous and subcutaneous mycoses to determine if the pathogens could be identified by molecular methods. aim of the study was to obtain a deep understanding of the spectrum of infectious agents, which, as we hypothesized, was not available by histopathology alone. detection of feline and fungal dna was achieved in 92.3% and 94.2% of the samples, respectively. mo ... | 2015 | 25550386 |
| biologically active and thermally stable polymeric schiff base and its metal polychelates: their synthesis and spectral aspects. | new metal polychelates of mn(ii), co(ii), ni(ii), cu(ii) and zn(ii) obtained by the interaction of metal acetates with polymeric schiff base containing formaldehyde and piperazine, have been investigated. structural and spectroscopic properties have been evaluated by elemental analysis, ft-ir and (1)h-nmr. geometry of the chelated polymers was confirmed by magnetic susceptibility measurements, uv-visible spectroscopy and electron spin resonance. the molecular weight of the polymer was determined ... | 2015 | 25955762 |
| phytochemical analysis, antibacterial, and antifungal assessment of aerial parts of polygonatum verticillatum. | the current study was designed to assess the phytochemical profile, antibacterial, and antifungal activities of the crude methanol extract of the aerial parts of polygonatum verticillatum (pa) and its various subsequent solvent fractions using agar well diffusion, agar tube dilution, and microdilution methods. phytochemical analysis showed positive for different chemical groups and also contained marked quantity of saponin and flavonoid contents. significant antibacterial activity was observed a ... | 2016 | 24311628 |
| antifungal, antiradical and cytotoxic activities of extractives obtained from tagetes patula l. (asteraceae), a potential acaricide plant species. | tagetes patula l. shows a complex chemical composition, ranging from glycosylated flavonoids and thiophenes in extracts until terpenoids in the essential oil. in the present study, due to this rich flavonoidic constitution, its antioxidant potential was determined, having shown values of antiradical percentage superior to reference compounds, mainly the extracts prepared with flowers. previous studies performed emphasized the acaricide potential of t. patula and thus, the present study aimed to ... | 2016 | 26945559 |
| cutaneous blastomycosis and dermatophytic pseudomycetoma in a persian cat from bangkok, thailand. | this is a case report of concurrent of blastomycosis and pseudomycetoma in a 3 year-old persian cat from bangkok, thailand. histopathology from antemortem and postmortem samples revealed blastomycosis and dermatophyte pseudomycetoma. the pcr analysis of the formalin-embedded tissue of antemortem sample confirmed that blastomycosis was caused by blastomyces dermatitidis. dermatophyte infection was caused by microsporum canis. according to the author's knowledge, this is the first case of blastomy ... | 2017 | 28116230 |
| composition, antifungal and antiproliferative activities of the hydrodistilled oils from leaves and flower heads of pterocephalus nestorianus nab. | this paper reports the first study of the chemical composition, and antifungal and antiproliferative properties of the volatile extracts obtained by hydrodistillation of the flower heads and leaves of the traditional kurdish medicinal plant p. nestorianus nab., collected in the wild. a total of fifty-five constituents, 43 of the flower heads' oil (pfo) and 46 of the leaves' oil (plo), respectively, were identified by gc/ms, constituting 99.68% and 99.04% of the two oils, respectively. the oils w ... | 2017 | 28217981 |
| antifungal properties of hypericin, hypericin tetrasulphonic acid and fagopyrin on pathogenic fungi and spoilage yeasts. | the role of hypericin-mediated photodynamic antimicrobial properties on pathogenic fungi and photodynamic therapy for human cancer cells is known. antifungal properties of hypericum perforatum l. (hypericaceae) and fagopyrum esculentum moench. (polygonaceae) extracts were also studied. the different polarities of solvents can cause complication in the identification of antifungal effects of separate biologically active compounds. in recent experimental work, we compared antifungal properties of ... | 2016 | 27564138 |
| lenghty reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) polymeric micelles and gels for sustained release of antifungal drugs. | in this work, we present a detailed study of the potential application of polymeric micelles and gels of four different reverse triblock poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) copolymers (boneombon, where n denotes the respective block lengths), specifically bo8eo90bo8, bo14eo378bo14, bo20eo411bo20 and bo21eo385bo21, as effective drug transport nanocarriers. in particular, we tested the use of this kind of polymeric nanostructures as reservoirs for the sustained delivery ... | 2016 | 27289012 |
| epidemiology of superficial mycoses in northern greece: a 4-year study. | superficial mycoses are defined as the fungal infections of skin, hair or nails that are caused by dermatophytes, yeasts and non-dermatophytic moulds. dermatophytes are the most frequently isolated fungi from specimens of patients with superficial mycoses. | 2016 | 25851424 |
| lawsonia inermis-mediated synthesis of silver nanoparticles: activity against human pathogenic fungi and bacteria with special reference to formulation of an antimicrobial nanogel. | lawsonia inermis mediated synthesis of silver nanoparticles (ag-nps) and its efficacy against candida albicans, microsporum canis, propioniabacterium acne and trichophyton mentagrophytes is reported. a two-step mechanism has been proposed for bioreduction and formation of an intermediate complex leading to the synthesis of capped nanoparticles was developed. in addition, antimicrobial gel for m. canis and t. mentagrophytes was also formulated. ag-nps were synthesized by challenging the leaft ext ... | 2014 | 25082226 |
| acyclic sesquiterpenes released by candida albicans inhibit growth of dermatophytes. | it is unresolved as to whether fungi that share a common skin habitat might in principal interact. in in vitro screening tests with candida albicans, trichophytum rubrum and other common dermatophytes, we found c. albicans releases volatile compounds that inhibit growth of the dermatophytes. by applying (enantioselective) gas chromatography combined with mass spectrometry we identified 8 compounds among which stereochemically pure (3r,6e)-2,3-dihydrofarnesol (r-dhf) and (2e,6e)-farnesol (f-ol) w ... | 2014 | 23902158 |
| antimicrobial activity of southern african medicinal plants with dermatological relevance: from an ethnopharmacological screening approach, to combination studies and the isolation of a bioactive compound. | ethnobotanical reports on more than 100 southern african medicinal plants with dermatological relevance have been highlighted, yet there is still limited scientific data to support claims for their antimicrobial effectiveness against skin pathogens. guided by ethnobotanical data, this paper explores the antimicrobial efficacies of southern african medicinal plants used to treat skin ailments. | 2013 | 23545456 |
| antifungal activity of arctotis arctotoides (l.f.) o. hoffm. and gasteria bicolor haw. against opportunistic fungi associated with human immunodeficiency virus/acquired immunodeficiency syndrome. | in south africa where many patients are immunocompromised as a result of the aids pandemic, opportunistic fungal infections such as candidiasis caused mainly by candida albicans are common. arctotis arctotoides and gasteria bicolor are two plants which are frequently and commonly used in traditional medicine in the treatment of hiv patients. | 2012 | 22701287 |
| chemical composition and antimicrobial activity of phyllanthus muellerianus (kuntze) excel essential oil. | phyllanthus muellerianus (kuntze) excel (family euphorbiaceae) stem bark is used in cameroon by baka pygmies as a remedy for wound healing and tetanus. | 2012 | 22683494 |
| antifungal activities of different extracts of marine macroalgae against dermatophytes and candida species. | algae are bioactive natural resources, and due to the medical importance of superficial mycoses, we focused the action of macroalgae extracts against dermatophytes and candida species. seaweed obtained from the riacho doce beach, alagoas (brazil), were screened for the antifungal activity, through crude extracts using dichloromethane, chloroform, methanol, ethanol, water and chloroform and hexane fractions of green, brown and red algae in assays with standard strains of the dermatophytes trichop ... | 2012 | 22528741 |
| antifungal activity of the essential oils of callitris neocaledonica and c. sulcata heartwood (cupressaceae). | mortality due to fungal infections has increased substantially, becoming a worldwide problem in public health. as a contribution to the discovery of new antifungal agents, the properties of the heartwood essential oils of two trees growing in new caledonia, callitris neocaledonica and c. sulcata (cupressaceae) were investigated. the essential oils extracted by hydrodistillation were characterized by gc-fid and gc/ms analyses. from c. neocaledonica oil, 31 constituents were identified, representi ... | 2012 | 22422531 |
| [superficial mycoses: casuistry of the mycology department of the instituto nacional de higiene "rafael rangel", caracas, venezuela (2001-2014)]. | the superficial mycoses are very common infectious diseases and therefore are a frequent reason for medical consultation. the aim of this study was to determine the diagnostic frequency of superficial mycoses in the mycology department of the instituto nacional de higiene "rafael rangel" during 14 years (2001-2014). a retrospective cross-sectional study was performed to review the mycological records of patients with presumptive diagnosis of superficial mycosis. nails, hairs and epidermal scales ... | 2016 | 27382801 |
| solid lipid nanoparticles containing copaiba oil and allantoin: development and role of nanoencapsulation on the antifungal activity. | the aim of this work was to develop solid lipid nanoparticles (sln) containing copaiba oil with and without allantoin (ncoa, nco, respectively) and to evaluate their antifungal activity. nanoparticle suspensions were prepared using a high homogenisation technique and characterised by dynamic light scattering, laser diffraction, nanoparticle tracking analysis, multiple light scattering analysis, high-pressure liquid chromatography, ph and rheology. the antifungal activities of the formulations we ... | 2015 | 25980176 |
| infectious diseases in large-scale cat hoarding investigations. | animal hoarders accumulate animals in over-crowded conditions without adequate nutrition, sanitation, and veterinary care. as a result, animals rescued from hoarding frequently have a variety of medical conditions including respiratory infections, gastrointestinal disease, parasitism, malnutrition, and other evidence of neglect. the purpose of this study was to characterize the infectious diseases carried by clinically affected cats and to determine the prevalence of retroviral infections among ... | 2014 | 24934262 |
| chemical characterisation and biological activity of leaf essential oils obtained from pistacia terebinthus growing wild in tunisia and sardinia island. | in the present work the chemical compositions, measured by gc and gc-ms, of the essential oils obtained by hydrodistillation from leaves of pistacia terebinthus collected in bizerte (tunisia) and baunei (italy) are reported. both essential oils possessed high content of monoterpene hydrocarbons (86.3% and 90.9%, respectively), being α-pinene (62.4 vs. 35.0)%, camphene (3.0 vs. 2.4)%, β-pinene (12.1 vs. 4.5)%, terpinolene (1.7 vs. 35.2)% and β-phellandrene (3.8 vs. 4.5)% the main components. the ... | 2017 | 28278668 |
| myrtus communis l. as source of a bioactive and safe essential oil. | in algeria, myrtus communis l. is distributed throughout the tell atlas and the coastal regions of algiers and constantine. the leaves are used in respiratory disorders, diarrhea and hemorrhoids. the aims of this work were to evaluate the antifungal and anti-inflammatory potential of well characterized essential oils (eo). since eo can be applied by inhalation, dermal application and oral administration, we used several mammalian cell lines to assess safe bioactive doses. the chemical compositio ... | 2015 | 25446467 |
| [dermatomycoses due to pets and farm animals : neglected infections?]. | dermatomycoses due to contact with pets and livestock frequently affect children and young adults. zoophilic dermatophytes are the main important causative agents. it has long been known that the often high inflammatory dermatophytoses of the skin and the scalp are caused mostly by microsporum canis. due to an absence of an obligation for reporting fungal infections of the skin to the public health office in germany, an unnoticed but significant change in responsible pathogens has occurred. toda ... | 2012 | 23114507 |
| in vitro antifungal potentials of bioactive compound oleic acid, 3-(octadecyloxy) propyl ester isolated from lepidagathis cristata willd. (acanthaceae) inflorescence. | to identify bioactive compound oleic acid, 3-(octadecyloxy) propyl ester from lepidagathis cristata willd. (l. cristata) and to assess antifungal potentials of the isolated compound. | 2014 | 25312119 |
| enzymatic and non-enzymatic virulence activities of dermatophytes on solid media. | dermatophytes are keratinophilic fungi causing superficial cutaneous infections that account 20-25% of the global population. as per literature search, there is a dearth in the study on virulence factors of dermatophytes from the indian sub-continent and moreover the association of the virulence factors and the host tissue in vitro helps in understanding the host-pathogen interaction. | 2017 | 28384862 |
| antidermatophytic and protease-inhibiting activities of zerumbone: a natural sesquiterpene from the rhizome of zingiber zerumbet (l.) roscoe ex j.e; smith. | due to increase in the number of patients with impaired immunity, incidence of dermatophytoses has increased considerably. antidermatophytic agents with anti-inflammatory and protease-inhibiting activities will help in restricting inflammatory response associated with dermatophytoses. | 2017 | 28216875 |
| computational analysis of conserved coil functional residues in the mitochondrial genomic sequences of dermatophytes. | dermatophyte is a group of closely related fungi that have the capacity to invade keratinized tissue of humans and other animals. the infection known as dermatophytosis, caused by members of the genera microsporum, trichophyton, and epidermophyton includes infection to the groin (tinea cruris), beard (tinea barbae), scalp (tinea capitis), feet (tinea pedis), glabrous skin (tinea corporis), nail (tinea unguium), and hand (tinea manuum). the identification of evolutionary relationship between thes ... | 2016 | 28149055 |
| inhibition of dermatophytes by photodynamic treatment with curcumin. | treatment of dermatophytoses with currently available antimycotic agents is often tedious and sometimes unsatisfactory. a search for better therapeutic methods-ideally with an immediate fungicidal effect-has, among others, lead to photodynamic procedures as a promising alternative, and recently curcumin was found to be a suitable agent for this application. in this study the effect of photodynamic treatment with curcumin on dermatophytes was tested in vitro wells of microtiter plates were filled ... | 2017 | 28053148 |
| epidemiology of dermatophytoses in crete, greece. | dermatophytoses are among the most frequently diagnosed skin infections worldwide. however, the distribution of pathogenic species and the predominating anatomical sites of infection vary with geographical location and change over time. the aim of this study was to determine the epidemiological and aetiological factors of dermatophytoses in crete, greece over the last 5-year period (2011-2015) and their incidence in relation to the gender and the age of the patients. we compared our findings wit ... | 2016 | 27904054 |
| the changing face of dermatophytic infections worldwide. | dermatophytes evolve along with the geography and socioeconomic conditions. epidermophyton floccosum, microsporum audouinii and trichophyton schoenleinii acted as the major pathogens of superficial fungal diseases 100 years ago, but their frequency decreased dramatically since the middle of the twentieth century and they are limited to some less-developed countries nowadays; meanwhile, frequency of trichophyton rubrum, trichophyton interdigitale, trichophyton tonsurans and microsporum canis incr ... | 2017 | 27783316 |
| antidermatophytic action of resorcinol derivatives: ultrastructural evidence of the activity of phenylethyl resorcinol against microsporum gypseum. | in this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. the antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatom ... | 2016 | 27706019 |
| characterization of clinically important dermatophytes in north of iran using pcr-rflp on its region. | dermatophytosis is considered as one of the major public health problems in the world. accurate identification of the dermatophytes species is important for recognition of the environment and animal sources of infection. in this survey, 1500 clinical specimens taken from outpatients suspected of dermatophytosis and they were examined by direct microscopy and culture. | 2016 | 27496524 |
| epidemiological aspects of dermatophytosis in khuzestan, southwestern iran, an update. | dermatophytosis is among the most common superficial mycoses in iran. the purpose of this report was to update the clinical and mycological features of human dermatophytosis in the khuzestan, southwestern iran. in the framework of a one-year survey, a total of 4120 skin, hair and nail samples obtained from the outpatients with symptoms suggestive of tinea were analyzed by using direct microscopy, culture and molecular identification methods. strains isolated from cultures were subjected to ampli ... | 2016 | 26886443 |
| phylogenetic analysis of dermatophyte species using dna sequence polymorphism in calmodulin gene. | use of phylogenetic species concepts based on rdna internal transcribe spacer (its) regions have improved the taxonomy of dermatophyte species; however, confirmation and refinement using other genes are needed. since the calmodulin gene has not been systematically used in dermatophyte taxonomy, we evaluated its intra- and interspecies sequence variation as well as its application in identification, phylogenetic analysis, and taxonomy of 202 strains of 29 dermatophyte species. a set of primers wa ... | 2016 | 26868901 |
| [2011 epidemiological survey of dermatomycoses in japan]. | an epidemiological survey of dermatomycoses and their causative fungus flora in japan for 2011 was conducted in accordance with methods and criteria of the past four surveys. the survey covered a total number of 36,052 outpatients who visited 12 dermatological clinics throughout japan. the results were as follows. 1）dermatophytosis was the most prevalent cutaneous fungal infection (2,980 cases) seen in these clinics, followed by candidiasis (378 cases) and then malassezia infections (152 cases). ... | 2015 | 26617109 |
| species identification of dermatophytes in paraffin-embedded biopsies with a new polymerase chain reaction assay targeting the internal transcribed spacer 2 region and comparison with histopathological features. | dermatophytosis is a very common skin infection with a broad clinical spectrum. biopsies are often used to confirm the diagnosis, especially when the clinical presentation is unusual. not uncommonly, organisms are hard to find even with periodic acid-schiff stains. polymerase chain reaction (pcr) for dermatophytes can be used in such cases. | 2016 | 26556042 |
| detection of common dermatophytes in clinical specimens using a simple quantitative real-time taqman polymerase chain reaction assay. | dermatophytes are common fungal pathogens causing mostly superficial infections in humans with a high prevalence worldwide. traditional detection techniques are time-consuming and insensitive, whereas molecular detection methods have proved to be much more rapid and sensitive. | 2016 | 26406273 |
| molecular characterization and in vitro antifungal susceptibility of 316 clinical isolates of dermatophytes in iran. | dermatophytosis is a common mycotic infection of the skin, nail, and hair, associated with major public health concern worldwide. various species of dermatophytes show significant differences in susceptibility to antifungals. here, we present the antifungal susceptibility of a large collection of molecularly identified dermatophyte isolates obtained from tropical region of south of iran. a total of 9485 patients clinically suspected to have cutaneous fungal infections were examined. dermatophyto ... | 2016 | 26369643 |
| dermatophytosis: a 16-year retrospective study in a metropolitan area in southern brazil. | dermatophytoses are considered a public health problem. the objectives of this study were to determine the evolution of their prevalence in the metropolitan area of porto alegre, brazil, and to analyze the dermatophyte species distribution according to body site and demographic characteristics of the patients. | 2015 | 26322879 |
| use of restriction fragment length polymorphism to rapidly identify dermatophyte species related to dermatophytosis. | dermatophytes are a group of keratinophilic fungi worldwide, which can infect the skin, hair and nails of humans and animals. this genus includes several species that present different features of dermatophytosis. although, laboratory diagnosis of dermatophytes is based on direct microscopy, biochemical tests and culture, these manners are expensive, time consuming and need skilled staff. therefore, molecular methods like pcr-rflp are the beneficial tools for identification, which are rapid and ... | 2015 | 26301058 |
| inhibitory effect of silver nanoparticles mediated by atmospheric pressure air cold plasma jet against dermatophyte fungi. | in an in vitro study with five clinical isolates of dermatophytes, the mic(50) and mic(100) values of silver nanoparticles (agnps) ranged from 5 to 16 and from 15 to 32 μg ml(- 1), respectively. the combined treatment of agnps with atmospheric pressure-air cold plasma (apacp) induced a drop in the mic(50) and mic100 values of agnps reaching 3-11 and 12-23 μg ml(- 1), respectively, according to the examined species. epidermophyton floccosum was the most sensitive fungus to agnps, while trichophyt ... | 2015 | 26296782 |
| a multi-target approach toward the development of novel candidates for antidermatophytic activity: ultrastructural evidence on α-bisabolol-treated microsporum gypseum. | multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. the antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: mi ... | 2015 | 26132903 |
| antidermatophytic activity of mikania micrantha kunth: an invasive weed. | the incidence of dermatophytosis has risen dramatically in recent years. limited availability of side-effect free drugs has led to a search for new antidermatophytic agents. | 2015 | 26109783 |
| anti-dermatophyte efficacy and environmental safety of some essential oils commercial and in vitro extracted pure and combined against four keratinophilic pathogenic fungi. | establish new biocontrol practices with low persistence in the environment against dermatophyte causing mycosis. | 2015 | 25953414 |
| antimicrobial and antioxidant activities and chemical characterization of essential oils of thymusvulgaris, rosmarinus officinalis, and origanum majorana from northeastern méxico. | there have been no reports of antifungal activity and composition of extracts from thymus vulgaris, rosmarinus officinalis or origanum majorana from northeastern méxico. antifungal activity of these oils against trichophyton rubrum, trichophyton tonsurans, trichophyton mentagrophytes, microsporum gypseum, microsporum canis and epidermophyton floccosum was measured by diffusion assay. additionally, antibacterial and antioxidant activities were evaluated. antibacterial activity against staphylococ ... | 2015 | 25631514 |
| investigation of in vitro activity of five antifungal drugs against dermatophytes species isolated from clinical samples using the e-test method. | dermatomycosis is an infection with fungi related to the skin: glabrous skin, hair and/or nails. oral treatment of fungal infections in dermatology has become a preferred modality for the management of these very common conditions. although there are increasing numbers of antifungals available for treatment of dermatophytes, some cases and relapses have been unresponsive to treatment. the determination of fungus in-vitro antifungal susceptibility has been reported to be important for the ability ... | 2014 | 25610290 |
| hemolytic activity of dermatophytes species isolated from clinical specimens. | hemolytic activity was recently reported for several pathogenic fungal species, such as aspergillus, candida, trichophyton, penicillium and fusarium. based on a number of mechanistic and characterization studies, several fungal hemolysins have been proposed as virulence factors. hemolysins lyse red blood cells resulting in the release of iron, an important growth factor for microbes especially during infection. the requirement of iron in fungal growth is necessary for metabolic processes and as ... | 2015 | 25467819 |
| an ancient plant lawsonia inermis (henna): determination of in vitro antifungal activity against dermatophytes species. | world is endowed with a rich wealth of medicinal plants. there is a widespread belief that green medicines are healthier and more harmless or safer than synthetic ones. medicinal plants have been used to cure a number of diseases. the ancient plant lawsonia inermis or henna is used as medicinal plant because of its attributed strong fungicidal, anti-inflammatory, analgesic, antibacterial, virucidal, antiparasitic, antiamoebiasis, astringent, antihemorrhagic, hypotensive, sedative, anticancer eff ... | 2014 | 25442917 |
| characterization of a new sesquiterpene and antifungal activities of chemical constituents from dryopteris fragrans (l.) schott. | one new sesquiterpene and six known compounds were isolated from dryopteris fragrans (l.) schot. they were identified as 3-o-β-d-glucopyranosylalbicanol- 11-o-β-d-glucopyranoside (1), dihydroconiferylalcohol (2), (e)-3-(4-hydroxyphenyl)acrylic acid (3), esculetin (4), 5,7-dihydroxy-2-hydroxymethylchromone (5), eriodictyol (6) and isoorientin (7) by uv, ms, 1d-nmr and 2d-nmr spectroscopy. the antifungal activities of the seven isolated compounds were screened. compounds 2, 3, 4 and 5 showed obvio ... | 2014 | 24451246 |
| [taxonomic study of clinic isolates of trichophyton in rosario, argentina]. | due to the pleomorphism and cultural variability displayed by species of the genus trichophyton, the identification methods based solely on morphological features are usually insufficient for their classification. the goal of the present work was to test a set of phenotypic methods in order to identify fungal isolates that belong to the aforementioned genus. these methods were based on a molecular taxonomic technique used as standard. clinical isolates (56) were used as samples along with 6 refe ... | 2014 | 24401778 |
| in vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes. | to investigate the antifungal drug susceptibility of fungi responsible for dermatomycoses, minimum inhibition concentration (mic) tests were performed in 44 strains of dermatophytes, including trichophyton rubrum, trichophyton mentagrophytes, trichophyton verrucosum, trichophyton tonsurans, microsporum canis, microsporum gypseum and epidermophyton floccosum, with six antifungal drugs (amorolfine, terbinafine, butenafine, ketoconazole, itraconazole and bifonazole) by broth microdilution assay acc ... | 2014 | 24215461 |
| a molecular epidemiological survey of clinically important dermatophytes in iran based on specific rflp profiles of beta-tubulin gene. | surveillance of dermatophytosis is essential to determine the likely changes in etiological trends and distribution profile of this infection. in this study beta tubulin gene (bt2), was used as the first time in a pcr-rflp format to clarify the distribution of dermatophytosis agents in some parts of iran. | 2013 | 26060667 |
| surveillance of dermatophytosis in northeast of iran (mashhad) and review of published studies. | dermatophytoses are considered to be one of the major public health problems in the world and are among the most commonly diagnosed skin diseases in iran. in spite of improved personal hygiene and living environment, dermatophytosis continues to spread and persist. to determine the prevalence of dermatophytosis and their etiologic agents in mashhad (iran), five hundred and sixty patients suspected to have fungal infection were studied. subjects who participated in this study were 330 males and 2 ... | 2013 | 23943426 |
| in vitro antifungal activity of naftifine hydrochloride against dermatophytes. | the incidence of superficial dermatophytoses is high in developed countries, and there remains a need for effective topical antifungals. in this study, we evaluated the in vitro antifungal activity of naftifine hydrochloride, the active ingredient in naftifine hydrochloride cream and gel 1% and 2%, against dermatophytes. the mics and minimum fungicidal concentrations (mfcs) of naftifine hydrochloride against 350 clinical strains, including trichophyton rubrum, t. mentagrophytes, t. tonsurans, ep ... | 2013 | 23817365 |
| public health significance of dermatophytes in ismailia and port said provinces, egypt. | [corrected] dermatophytes are common in both developed and developing countries, the species involved and the resulting clinical entities vary geographically. | 2013 | 23760076 |
| the use of albino adult hair and blond prepubertal hair yields equivalent results in an in vitro hair perforation test to differentiate between different dermatophytic fungi. | an in vitro hair perforation test is used to differentiate isolates of trichophyton mentagrophytes and trichophyton rubrum complexes because morphological criteria are insufficient. here, we performed in vitro hair perforation tests using blond prepubertal hair and albino adult hair to determine whether they differentiate between fungal species. we tested 43 well-characterized dermatophyte strains, arthroderma spp. [n = 4], epidermophyton floccosum [n = 1], microsporum spp. [n = 8], and trichoph ... | 2013 | 23591622 |
| [2006 epidemiological survey of dermatomycoses in japan]. | an epidemiological survey of dermatomycoses and the causative fungus flora of dermatomycoses in japan for 2006 was made on a total number of 63,029 outpatients who visited 16 dermatological clinics throughout japan. the results were as follows. 1) dermatophytosis was the most prevalent cutaneus fungal infection (7,582 cases) seen in these clinics, followed by candidiasis (842 cases) and then malassezia infections (283 cases). 2) among dermatophytoses, tinea pedis was the most frequent (4,779 cas ... | 2012 | 23149353 |
| in vitro antifungal activity of micafungin and caspofungin against dermatophytes isolated from china. | the aims of this study are to investigate the in vitro activities of micafungin and caspofungin that are two new echinocandin antifungal drugs against clinically isolated dermatophytes in china and to define mec (minimal effective concentration) as the reading endpoints of this study in accordance with (clinical and laboratory standards institute) clsi m38-a2 reference. | 2013 | 22983900 |
| epidemiology of dermatophytoses in crete, greece between 2004 and 2010. | the present work was undertaken in order to study the epidemiology of dermatophytoses in the island of crete, greece, over a 7-year period (2004-2010) and to compare the results with those reported earlier from this region and from other parts of the world. | 2012 | 22648332 |
| molecular epidemiology of dermatophytosis in tehran, iran, a clinical and microbial survey. | in the framework of a survey on dermatophytoses, 14,619 clinical specimens taken from outpatients with symptoms suggestive of tinea and referred to a medical mycology laboratory in tehran, iran, were analyzed by direct microscopy and culture. in total, 777 dermatophyte strains recovered in culture were randomly identified by a formerly established rflp analysis method based on the rdna its regions. for confirmation of species identification, 160 isolates representing the likely entire species sp ... | 2013 | 22587730 |
| maldi-tof mass spectrometry - a rapid method for the identification of dermatophyte species. | altogether 285 dermatophyte isolates of 21 different species - including both trichophyton rubrum and t. interdigitale, but also eight additional trichophyton species, microsporum canis and seven other microsporum species, as well as epidermophyton floccosum and arthroderma spp. - were analyzed using matrix assisted laser desorption ionization time-of-flight mass spectrometry (maldi-tof ms) and the anagnostec 'saramis' (spectral archiving and microbial identification system) software. in additio ... | 2013 | 22574631 |
| dermatophyte infections mimicking other skin diseases: a 154-person case survey of tinea atypica in the district of cagliari (italy). | although usually simple, the diagnosis of dermatophyte infection is sometimes neglected. an observational study has been realized to evaluate the role of corticosteroid exposure (tinea incognito) and of other primary characteristics of the dermatophytosis that from onset mimic other diseases and mislead an unexperienced physician. | 2012 | 22435428 |
| inhibition of dermatophytes by the antimicrobial peptides human β-defensin-2, ribonuclease 7 and psoriasin. | previous studies have described some antibacterial effects of antimicrobial peptides (amps) expressed in human skin, but little is known about their possible activity against dermatophytes. therefore we have tested the effects of human β-defensin 2 (hbd-2), ribonuclease 7 (rnase 7) and psoriasin on the in vitro growth of four dermatophyte species. germinating conidia of trichophyton rubrum, t. mentagrophytes, microsporum canis and epidermophyton floccosum were exposed in vitro to hbd-2, rnase 7, ... | 2012 | 22332906 |
| a multicenter clinicomycological study evaluating the spectrum of adult tinea capitis in egypt. | tinea capitis (tc) is a common fungal infection in children but is less frequently encountered in adults. this study evaluates the clinical characteristics and mycological studies of adult tc among the egyptian population. | 2013 | 24336943 |
| therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products. | this study examined whether the antidermatophytic activity of essential oils (eos) can be used as an indicator for the discovery of active natural products against leishmania amazonensis. the aerial parts of seven plants were hydrodistilled. using broth microdilution techniques, the obtained eos were tested against three strains of dermatophytes (trichophyton mentagrophytes, microsporum gypseum and microsporum canis). to compare the eos antifungal and antiparasitic effects, the eos activities ag ... | 2015 | 25742270 |
| therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products. | this study examined whether the antidermatophytic activity of essential oils (eos) can be used as an indicator for the discovery of active natural products against leishmania amazonensis. the aerial parts of seven plants were hydrodistilled. using broth microdilution techniques, the obtained eos were tested against three strains of dermatophytes (trichophyton mentagrophytes, microsporum gypseum and microsporum canis). to compare the eos antifungal and antiparasitic effects, the eos activities ag ... | 2015 | 25714080 |
| antifungal, antileishmanial, and cytotoxicity activities of various extracts of berberis vulgaris (berberidaceae) and its active principle berberine. | in this study, in vitro antidermatophytic activity against trichophyton mentagrophytes, trichophyton rubrum, microsporum canis, and microsporum gypseum was studied by disk diffusion test and assessment of minimum inhibitory concentration (mic) using clsi broth macrodilution method (m38-a2). moreover, antileishmanial and cytotoxicity activity of b. vulgaris and berberine against promastigotes of leishmania major and leishmania tropica were evaluated by colorimetric mtt assay. the findings indicat ... | 2014 | 24977052 |
| mycology - an update. part 1: dermatomycoses: causative agents, epidemiology and pathogenesis. | dermatomycoses are caused most commonly by dermatophytes. the anthropophilic dermatophyte trichophyton rubrum is still the most frequent causative agent worldwide. keratinolytic enzymes, e.g. hydrolases and keratinases, are important virulence factors of t. rubrum. recently, the cysteine dioxygenase was found as new virulence factor. predisposing host factors play a similarly important role for the development of dermatophytosis of the skin and nails. chronic venous insufficiency, diabetes melli ... | 2014 | 24533779 |
| tinea atypica: report of nine cases. | fungal infections of the skin are a common condition, usually easy to diagnose and treat. when the infection is clinically mimicking another cutaneous disorder or when the clinical presentation is modified by the use of inappropriate treatment, it is referred to as tinea atypica or tinea incognito.we report a series of nine cases of patients with tinea atypica, imitating and diagnosed initially as different skin diseases. two patients were defined as pyoderma in the facial and pubic regions (cau ... | 2013 | 23949566 |
| isolation of sporothrix schenckii from the claws of domestic cats (indoor and outdoor) and in captivity in são paulo (brazil). | sporotrichosis is a subcutaneous mycosis and is also a zoonosis (sapro- and anthropozoonosis). the objective of the present study was to determine the occurrence of sporotrichosis in domestic cats and in wild or exotic felines in captivity through the isolation of sporothrix spp. from claw impressions in a culture medium. the samples included 132 felines, of which 120 (91.0 %) were domestic cats, 11 (8.3 %) were wild felines, and one (0.7 %) was an exotic felid. twenty-one (17.5 %) were outdoor ... | 2013 | 23729233 |
| pcr and real-time pcr approaches to the identification of arthroderma otae species microsporum canis and microsporum audouinii/microsporum ferrugineum. | the identification of species in the arthroderma otae complex is essential to determine the origin of infection and to eliminate the risk of transmission. microsporum canis is a zoophilic species, whereas microsporum audouinii and microsporum ferrugineum are anthropophilic species. in this paper, we propose alternative methods that permit species-specific identification of both anthropophilic and zoophilic members of the a. otae complex methods: two pcr assays were designed based on differences ... | 2016 | 27306227 |
| tinea capitis: temporal shift in pathogens and epidemiology. | tinea capitis is the most common type of dermatomycosis in children. its pathogen profile shows geographic variations as well as temporal shifts. | 2016 | 27509419 |
| tinea capitis: erregerspektrum und epidemiologie im zeitlichen wandel. | die tinea capitis ist die häufigste dermatomykose des kindesalters. das erregerprofil zeigt unterschiedliche geographische verteilungsmuster und variiert im laufe der zeit. | 2016 | 27509418 |
| isolation, identification, and in vitro antifungal susceptibility testing of dermatophytes from clinical samples at sohag university hospital in egypt. | the objective of this study was to isolate, identify, and explore the in-vitro antifungal susceptibility pattern of dermatophytes isolated from clinically suspected cases of dermatophytosis (tinea infections) attending the dermatology outpatient clinic. | 2016 | 27504173 |
| development of enzyme immunoassays (elisa and western blot) for the serological diagnosis of dermatophytosis in symptomatic and asymptomatic cats. | dermatophytosis is the most common fungal infection in cats worldwide and plays an important role in both animal and human health due to their high zoonotic potential. effective screening is a strong preventive measure and the fungal culture is quite useful but requires full laboratorial experience and it takes a long time to obtain the result. a rapid and accurate screening test for dermatophytosis in cats is crucial for the effective control of disease outbreaks. the aim of this study was to d ... | 2017 | 28340215 |
| evaluation of growth conditions and dna extraction techniques used in the molecular analysis of dermatophytes. | recent molecular methods for diagnosis of superficial mycoses have determined the need for a rapid and easy method of extracting dna. the aim of study was to determine growth conditions and techniques of dna extraction for microsporum canis, trichophyton mentagrophytes and t. verrucosum. | 2017 | 28236353 |
| changing in the epidemiology of tinea capitis among school children in egypt. | tinea capitis remains a prevalent health problem among school-aged children. | 2017 | 28223741 |
| intra-abdominal fungal pseudomycetoma in two cats. | pseudomycetomas are deep cutaneous to subcutaneous lesions caused by microsporum canis mainly described in persian cats, with few reports of intra-abdominal location. this report describes the clinical signs and lesions of intra-abdominal pseudomycetomas caused by m. canis in two persian cats. | 2017 | 28214274 |
| inibitory effects of linalool on fungal pathogenicity of clinical isolates of microsporum canis and microsporum gypseum. | in humans worldwide, microsporum sp. is a frequent agent of dermatophytsosis. when considering the emergence of resistant fungi and the clinical relevance of dermatophytosis, terpene antifungal activity is of great interest. linalool is a monoterpene alcohol with pharmacological properties. in this study, antifungal in vitro activity of linalool and ketoconazole (as a positive control) were evaluated against clinical isolates of m. canis and m. gypseum. the minimum inhibitory concentration (mic) ... | 2017 | 28198097 |
| ultraviolet dermoscopy for the diagnosis of tinea capitis. | | 2017 | 28087021 |
| modeling dermatophytosis in reconstructed human epidermis: a new tool to study infection mechanisms and to test antifungal agents. | dermatophytosis is a superficial fungal infection of keratinized structures that exhibits an increasing prevalence in humans and is thus requesting novel prophylactic strategies and therapies. however, precise mechanisms used by dermatophytes to adhere at the surface of the human epidermis and invade its stratum corneum are still incompletely identified, as well as the responses provided by the underlying living keratinocytes during the infection. we hereby report development of an in vitro mode ... | 2016 | 27760830 |
| efficacy of topical therapy with newly developed terbinafine and econazole formulations in the treatment of dermatophytosis in cats. | in the field of veterinary dermatology dermatophytosis is one of the most frequently occurring infectious diseases, therefore its treatment should be effective, convenient, safe and inexpensive. the aim of this study was to evaluate the efficacy of newly developed topical formulations in the treatment of cats with dermatophytosis. evaluation of clinical efficacy and safety of terbinafine and econazole formulations administered topically twice a day was performed in 40 cats. cats, suffering from ... | 2016 | 27760032 |
| isolation and identification of microsporum canis from asian elephants (elephas maximus) in the chongqing zoo, china. | skin diseases affect millions of people and animals worldwide, including asian elephants. this study sought to determine the pathogen of skin diseases that occurred in asian elephants in chongqing zoo, china. the isolated fungus was identified through its cultural characteristics, morphology, and polymerase chain reaction (pcr) amplification. the pcr amplification using common fungal primers (its1 and its4) determined that the pathogen was 99.7% homologous to microsporum canis. this is the first ... | 2016 | 27691957 |
| tinea on a tattoo. | in the last twenty years, the prevalence of individuals with tattoos in the general population has increased in europe (1) as well as in australia (2) and the united states of america (3). a series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. infectious complications on ... | 2016 | 27663926 |