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[cat scratch disease: report of a case]. 200718021527
genomic analysis of bartonella identifies type iv secretion systems as host adaptability factors.the bacterial genus bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. we determined the comp ...200718037886
diversifying selection and concerted evolution of a type iv secretion system in bartonella.we have studied the evolution of a type iv secretion system (t4ss), in bartonella, which is thought to have changed function from conjugation to erythrocyte adherence following a recent horizontal gene transfer event. the system, called trw, is unique among t4sss in that genes encoding both exo- and intracellular components are located within the same duplicated fragment. this provides an opportunity to study the influence of selection on proteins involved in host-pathogen interactions. we seque ...200818065487
[using direct enzyme linked immunosorbent assay for the detection of igg antibody on bartonella henselae among healthy people in changping, beijing].to detect bartonella henselae igg antibody among healthy people in changping, beijing.200718069561
[stroke as a manifestation of acute bartonella henselae endocarditis].bartonella, a small gram-negative bacillus, causes a variety of diseases and presents with different clinical manifestations, one of which is infective endocarditis (ie). ie due to b. henselae is associated with a high risk of morbidity and mortality due to the destructive potential of the organism to the heart valves and due to the great risk of embolic complications.200718087840
isolation and characterization of bartonella bacilliformis from an expatriate ecuadorian.carrion's disease is typically biphasic with acute febrile illness characterized by bacteremia and severe hemolytic anemia (oroya fever), followed by benign, chronic cutaneous lesions (verruga peruana). the causative agent, bartonella bacilliformis, is endemic in specific regions of peru and ecuador. we describe atypical infection in an expatriate patient who presented with acute splenomegaly and anemia 3 years after visiting ecuador. initial serology and pcr of the patient's blood and serum wer ...200818094131
multi-locus sequence typing of bartonella henselae isolates from three continents reveals hypervirulent and feline-associated clones.bartonella henselae is a zoonotic pathogen and the causative agent of cat scratch disease and a variety of other disease manifestations in humans. previous investigations have suggested that a limited subset of b. henselae isolates may be associated with human disease. in the present study, 182 human and feline b. henselae isolates from europe, north america and australia were analysed by multi-locus sequence typing (mlst) to detect any associations between sequence type (st), host species and g ...200718094753
bartonella henselae infects human erythrocytes.bartonella henselae, a facultative intracellular bacterium, has been known as the agent of cat scratch disease, bacillary angiomatosis, peliosis hepatis, endocarditis, and bacteremic syndrome in humans. bartonella species can cause intraerythrocytic infections and have been isolated from the bloodstream of patients by several methods. it was demonstrated that b. bacilliformis and b. quintana infect human endothelial cells and human erythrocytes and b. henselae infects erythrocytes of cats. the a ...200718098053
severe anemia, panserositis, and cryptogenic hepatitis in an hiv patient infected with bartonella henselae.bartonella spp. constitute emerging pathogens of worldwide distribution. bacillary angiomatosis is the most frequent skin manifestation of bartonelloses; nevertheless, b. henselae infection should always be considered systemic, especially in immunodeficient individuals. the authors report the case of an aids patient with bacillary angiomatosis, who had concurrent severe anemia, hepatitis, peritonitis, pleuritis, and pericarditis. clinical manifestation, electronic microscopic examination of eryt ...200718098054
bacillary angiomatosis in an hiv-positive man with multiple risk factors: a clinical and epidemiological puzzle.a 36-year-old man with advanced aids presented with skin lesions, fever and weight loss. physical examination revealed skin lesions suggestive of bacillary angiomatosis. diagnostic imaging identified bone lesions, soft tissue masses and a single hepatic lesion. his clinical presentation was most consistent with bartonella quintana; however, his risk for infection with b quintana was limited to a remote, brief period of homelessness. in contrast, his frequent contact with cats presented substanti ...200518159553
bacillary angiomatosis in a patient with chronic lymphocytic leukemia.bacillary angiomatosis is a cutaneous or visceral infection with bartonella henselae or bartonella quintana. cases usually occur in hiv infected individuals. we present a 60-year-old man with chronic lymphocytic leukemia and neutropenic fever caused by bacillary angiomatosis. the nine ba cases in oncology patients are reviewed.200818165862
[a case of cat scratch disease].cat scratch disease (csd) which is usually seen in children and young adults and characterized by self limited lymphadenopathy, is caused by bartonella henselae. in this report, a 30-year-old male patient who was admitted to the outpatient clinic with the complaint of lymphadenopathy, was presented. erythrocyte sedimentation rate and c reactive protein values of the patient were normal, and anti-hiv, brucella agglutination and anti-toxoplasma igm and igg tests were negative. no bacterial growth ...200718173081
[stellar neuroretinitis and bartonella henselae infection. a case report without exposure to cats]. 200818187281
musculoskeletal manifestations of cat scratch disease.musculoskeletal manifestations (mms) are considered to be rare in cat scratch disease (csd) and are not well characterized. we aimed to study mms of csd.200718190312
from cat scratch disease to bartonella henselae infection. 200718190313
hepatosplenic cat-scratch fever. 200818222165
prolonged bartonella henselae bacteremia caused by reinfection in cats.we analyzed the genetic relatedness of blood culture isolates of bartonella henselae from 2 cats of patients with cat-scratch disease at admission and after 12 months. isolates from each cat at different times were clonally unrelated, which suggested reinfection by a second strain.200818258096
[ocular bartonellosis: report of three clinical cases].the characteristic clinical presentation of cat scratch disease is subacute regional lymphadenopathy; nevertheless, 5-25% of bartonella henselae infections may present an atypical or systemic form, with potential eye involvement. we describe three clinical cases of ocular bartonellosis in two adolescents and one young adult, who had close contact with cats; all of them presented persistent fever ranging from 15 to 21 days, and two of them developed a sudden unilateral loss of visual acuity assoc ...200818273527
bartonella dna in the blood and lymph nodes of golden retrievers with lymphoma and in healthy controls.although lymphoma is the most common neoplastic process reported in dogs, its precise etiology is unknown. golden retrievers are more likely to develop lymphoma, suggesting a breed predisposition; however, other factors, including environment, immunity, and infection, are likely contributors to oncogenesis.200818289294
lymphadenopathy in a novel mouse model of bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta.in immunocompetent humans, cat scratch disease (csd) is elicited by the gram-negative bacterium bartonella henselae and is characterized by a benign regional lymphadenopathy, the pathogenesis of which is poorly understood. here, we describe a novel mouse model of bartonella-induced csd-like disease that allowed us to investigate the mechanisms leading to lymphadenopathy in vivo. in wild-type mice, a subcutaneous inoculation of either viable or inactivated b. henselae led to a strong swelling of ...200818292236
serological evidence of bartonella henselae infection in healthy people in catalonia, spain.cat scratch disease (csd), bacillary angiomatosis, hepatic peliosis and some cases of bacteraemia, endocarditis, and osteomyelitis are directly caused by some species of the genus bartonella. the purpose of this study was to determine the prevalence of igg antibodies against bartonella henselae in healthy people and to identify the epidemiological factors involved. serum samples from 218 patients were examined by indirect immunofluorescence assay (ifa). significance levels for univariate statist ...200818294428
feline bartonellosis and cat scratch disease.bartonella species are important emerging zoonotic pathogens. transmission of these organisms in nature may be much more complex than is currently appreciated. cats can be infected with five bartonella species, including, bartonella henselae, bartonella clarridgeae, bartonella bovis, bartonella koehlerae and bartonella quintana. in addition to cats, numerous domestic and wild animals, including bovine, canine, human, and rodent species can serve as chronically infected reservoir hosts for variou ...200818295347
hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases.the incidence of hepatic granulomas is reported in 2-15% of liver biopsies. this study was carried out to evaluate the incidence and aetiology of hepatic granulomas in a german institute of pathology with specialization in liver diseases.200818312287
bartonella native valve endocarditis: the first brazilian case alive and well.bartonella is an important cause of blood culture-negative endocarditis in recent studies. seroprevalence studies in the states of minas gerais and rio de janeiro have shown bartonella igg positivity around 14% in healthy adults and 40% in hiv seropositive adults, respectively. a case report of a 46-year-old white male with moderate aortic regurgitation (ar) due to rheumatic heart disease (rhd), admitted due to worsening heart failure, is presented. clinical features were apyrexia, anemia, polyc ...200718327472
heterogeneity of susceptibility to fluoroquinolones in bartonella isolates from australia reveals a natural mutation in gyra.bartonella sp. are intracellular bacteria associated with an increasing number of clinical manifestations but with few published data on in vitro susceptibility testing of antibiotics. our objective was to evaluate in vitro antibiotic susceptibilities of 20 new bartonella isolates from animals in australia.200818334491
detection of bartonella henselae in the blood of 2 adult horses.bartonella spp. are emerging zoonotic agents that have been found in a wide variety of domestic animals and wildlife and cause a number of clinical syndromes. bartonella sp. infection has been identified in a growing number of animal species, including cats, rodents, porpoises, and canids, but has not been reported in horses.200818346149
abscess-forming lymphadenopathy and osteomyelitis in children with bartonella henselae infection.bartonella henselae is the agent of cat-scratch disease (csd), a chronic lymphadenopathy among children and adolescents. a systemic infection is very rare and most of these cases are found in patients with immunodeficiency. here, cases involving four children of 6-12 years of age are reported. three of the children had an abscess-forming lymphadenopathy and surrounding myositis in the clavicular region of the upper arm. the diagnosis was made serologically and, in one case, using eubacterial uni ...200818349375
[a high prevalence of antibodies against bartonella and babesia microti has been found in villages and urban populations in cordoba, colombia].establishing seroprevalence against bartonella and babesia microti in arural population exposed and/or non-exposed to domestic animals in cordoba,colombia.200818368229
bartonella endocarditis in complex congenital heart disease.bartonella species are an important cause of culture-negative endocarditis, with recognized risk factors of alcoholism, homelessness, cat exposure, and pre-existing valvular disease. we report a case of bartonella henselae endocarditis in a 36-year-old woman with complex congenital heart disease who presented with a 7-month history of hemolytic anemia, leukocytoclastic vasculitis, and recurrent fevers. transesophageal echocardiogram revealed vegetations on the patient's native aortic valve and i ...200718377522
atypical bartonella hensalae chorioretinitis in an immunocompromised patient.to report an atypical case of chorioretinopathy in a patient with bilateral renal transplantations.200818379943
bartonella species antibodies and dna in cerebral spinal fluid of cats with central nervous system disease.bartonella species infection is associated with central nervous system (cns) disease in some humans and cats but the diagnosis is difficult to confirm with blood or serum test results. in this retrospective study of 100 client-owned cats, serum and cerebral spinal fluid (csf) were assayed for bartonella species igg antibodies and csf was assayed for bartonella species dna. bartonella species igg antibodies were detected in serum of 36 cats, bartonella species c-values>1 (suggesting antibody prod ...200818400536
emerging pathogens: challenges and successes of molecular diagnostics.more than 50 emerging and reemerging pathogens have been identified during the last 40 years. until 1992 when the institute of medicine issued a report that defined emerging infectious diseases, medicine had been complacent about such infectious diseases despite the alarm bells of infections with human immunodeficiency virus. molecular tools have proven useful in discovering and characterizing emerging viruses and bacteria such as sin nombre virus (hantaviral pulmonary syndrome), hepatitis c vir ...200818403608
visceral involvement in an immunocompetent male: a rare presentation of cat scratch disease.we report a case of an adult, immunocompetent male with lymphadenopathy of both groins, para-aortal lymph nodes and multiple lesions in the spleen. a neoplasm was excluded by histology of the largest lymph node from the left groin. the diagnosis of cat-scratch disease (csd ) became apparent when serological testing for bartonella henselae showed to be positive. a review of literature shows that disseminated (visceral) infection is a rare presentation of csd.200818424863
beyond cat scratch disease: widening spectrum of bartonella henselae infection.bartonella henselae was discovered a quarter of a century ago as the causative agent of cat scratch disease, a clinical entity described in the literature for more than half a century. as diagnostic techniques improve, our knowledge of the spectrum of clinical disease resulting from infection with bartonella is expanding. this review summarizes current knowledge regarding the microbiology, clinical manifestations, diagnostic techniques, and treatment of b. henselae infection.200818443019
[bartonella henselae and its infections].in recent years the number of identified bartonella species has increased rapidly and several species in bartonella genus isolated from various mammalian reservoirs were recognized as zoonotic agents in humans. three bartonella species are considered to be pathogenic for humans; b. henselae, b. quintana and b. bacilliformis. b. henselae causes asymptomatic intraerythrocytic bacteraemia in the feline reservoir host and is the most important zoonotic species as the cause of human diseases includin ...200818444576
seroprevalence of bartonella spp. infection in hiv patients in catalonia, spain.although the first clinical descriptions of bartonella infection were associated with immunocompromised patient with bacillary angiomatosis, we currently know that this organism is directly involved in diseases affecting a large number of patients, regardless of their immune status. cat scratch disease, hepatic peliosis, and some cases of bacteraemia and endocarditis, are directly caused by some species of the genus bartonella. the purpose of this study was to determinate the prevalence of igg a ...200818452613
severe occlusive vasculitis as a complication of cat scratch disease.the purpose of this communication is to report a severe occlusive vasculitis as a complication of cat scratch.200818454406
culture-negative infectious endocarditis caused by bartonella spp.: 2 case reports and a review of the literature.bartonella spp. are rare pathogens in humans and were recently recognized as important causative agents of culture-negative endocarditis. here, we describe the 1st 2 documented cases of culture-negative endocarditis due to bartonella henselae and bartonella quintana encountered in a single hospital in germany. infection of the heart valve tissue was detected by broad-range polymerase chain reaction (pcr) and further confirmed by serologic testing. in particular, acute b. henselae infection with ...200818455348
macular hole following bartonella henselae neuroretinitis.to report a case of macular hole secondary to bartonella henselae neuroretinitis.200818465733
[cat scratch disease]. 200818470500
molecular evidence for bartonella spp. in cat and dog fleas from germany and france.nine hundred and fifty-two fleas were collected from 148 cats and 133 dogs at 18 widely distributed geographic locations in germany and france and examined for the presence of six different bartonella spp. (bartonella bacilliformis, bartonella clarridgeiae, bartonella elizabethae, bartonella henselae, bartonella quintana, bartonella vinsonii subsp. berkhoffii) by pcr. thirty-five specimens (3.7%) tested positive for either b. henselae (14 positive fleas) or b. clarridgeiae (21 positive fleas). d ...200818489542
native valve endocarditis due to bartonella henselae in an immunocompetent man.culture-negative endocarditis accounts for 2.5-31% of all endocarditis cases and remains a diagnostic and therapeutic challenge. bartonella spp. has only recently been recognized as an important cause of culture-negative endocarditis. we report a case of bartonella henselae endocarditis occurring in an immunocompetent man who owned a cat and had previously been diagnosed with valvulopathy. diagnosis was made only after prolonged diagnostic work-up with serology and with pcr and subsequent sequen ...200818500601
use of bartonella adhesin a (bada) immunoblotting in the serodiagnosis of bartonella henselae infections.bartonella henselae causes a variety of human diseases (e.g. cat scratch disease and the vasculoproliferative disorders, bacillary angiomatosis and peliosis hepatis). the laboratory diagnosis of b. henselae infections is usually based on the detection of anti-b. henselae antibodies by an indirect immunofluorescence assay (ifa) which, unfortunately, suffers from a significant amount of cross-reactivity and hence is prone to deliver false-positive results. in this pilot study, we evaluated the use ...200818501673
rickettsial seroepidemiology among farm workers, tianjin, people's republic of china.high seroprevalence rates for anaplasma phagocytophilum (8.8%), coxiella burnetii (6.4%), bartonella henselae (9.6%), and rickettsia typhi (4.1%) in 365 farm workers near tianjin, people's republic of china, suggest that human infections with these zoonotic bacteria are frequent and largely unrecognized. demographic features of seropositive persons suggest distinct epidemiology, ecology, and risks.200818507907
[cat-scratch disease localisation in the parotid gland].cat scratch disease is an infection due to bartonella henselae. it is one of the principal causes of benign chronic adenopathy in children or young adults.200818533210
bartonella henselae: first reported isolate in a human in thailand.this is the first reported case of bacillary angiomatosis associated with bartonella henselae in thailand. the clinical, pathological, and microbiological findings are presented. the bacterium was isolated from a biopsy of skin lesions obtained on admission and identified by cellular morphology, characteristics of colonies on chocolate agar, extensive biochemical tests and 16s ribosomal dna sequencing.200818567451
detrimental effects of bartonella henselae are counteracted by l-arginine and nitric oxide in human endothelial progenitor cells.the recruitment of circulating endothelial progenitor cells (epcs) might have a beneficial effect on the clinical course of several diseases. endothelial damage and detachment of endothelial cells are known to occur in infection, tissue ischemia, and sepsis. these detrimental effects in epcs are unknown. here we elucidated whether human epcs internalize bartonella henselae constituting a circulating niche of the pathogen. b. henselae invades epcs as shown by gentamicin protection assays and tran ...200818595894
transmission of bartonella henselae by ixodes ricinus.bartonella spp. are facultative intracellular bacteria associated with several emerging diseases in humans and animals. b. henselae causes cat-scratch disease and is increasingly associated with several other syndromes, particularly ocular infections and endocarditis. cats are the main reservoir for b. henselae and the bacteria are transmitted to cats by cat fleas. however, new potential vectors are suspected of transmitting b. henselae, in particular, ixodes ricinus, the most abundant ixodid ti ...200818598628
seroprevalence of bartonella henselae antibodies in blood donors in crete. 200818609206
inguinal lymphadenopathy due to bartonella henselae.the bacterium bartonella henselae causes cat scratch disease, a self-limited zoonotic disease which is common among children and adolescents. the most typical clinical presentation is a regional lymphadenopathy that commonly involves only a single node of cervical and axillary lymph nodes. inguinal localization is rarely described. we report a case of a 35-year-old caucasian male complaining of a painless right inguinal mass and slight fever. a diagnosis of bartonella henselae infection was made ...200818622149
immune thrombocytopenic purpura as a complication of bartonella henselae infection.immune thrombocytopenic purpura is an infrequent yet well-recognized complication of viral infections, such as mumps, rubella, varicella, cytomegalovirus, parvovirus and infectious monunucleosis by epstein-barr virus. some recent studies have described a possible association between henoch-schonlein purpura, a non-thrombocytopenic purpura, and seropositivity for bartonella henselae, but in the literature only sporadic case reports have described a severe immune thrombocytopenic purpura as a comp ...200818622151
the head of bartonella adhesin a is crucial for host cell interaction of bartonella henselae.human pathogenic bartonella henselae cause cat scratch disease and vasculoproliferative disorders (e.g. bacillary angiomatosis). expression of bartonella adhesin a (bada) is crucial for bacterial autoagglutination, adhesion to host cells, binding to extracellular matrix proteins and proangiogenic reprogramming via activation of hypoxia inducible factor (hif)-1. like the prototypic yersinia adhesin a, bada belongs to the class of trimeric autotransporter adhesins and is constructed modularly cons ...200818627378
low sensitivity of bartonella henselae pcr in serum samples of patients with cat-scratch disease lymphadenitis. 200818628513
bartonella sp. bacteremia in patients with neurological and neurocognitive dysfunction.we detected infection with a bartonella species (b. henselae or b. vinsonii subsp. berkhoffii) in blood samples from six immunocompetent patients who presented with a chronic neurological or neurocognitive syndrome including seizures, ataxia, memory loss, and/or tremors. each of these patients had substantial animal contact or recent arthropod exposure as a potential risk factor for bartonella infection. additional studies should be performed to clarify the potential role of bartonella spp. as a ...200818632903
cat scratch disease complicated with aseptic meningitis and neuroretinitis.cat scratch disease (csd) is a self limited condition characterized by fever, lymph node enlargement and less often eye involvement. central nervous system involvement by bartonella henselae infection is possibly an important cause of morbidity; its role as an agent of aseptic meningitis is unknown. we report a case of a 40 years-old man with csd accompanied by aseptic meningitis and neuroretinitis. serum indirect immmunofluorescence (ifi) assays for b. henselae were positive and the cerebrospin ...200818641856
ocular bartonella infections. 200818645403
possible donor-recipient bartonellosis transmission in a pediatric liver transplant.bartonella henselae is the causative agent of cat-scratch disease and other disorders, including hepatosplenic granulomatosis. this infection has only rarely been reported after solid organ transplantation, where it can mimic the more common post-transplant lymphoproliferative disease. here we present a case of asymptomatic b. henselae hepatic and lymph nodal granulomatosis in a pediatric patient who had received orthotopic liver transplant 2 months before; we hypothesize that the causative agen ...200818651873
serological evidence for the association of bartonella henselae infection with arrhythmogenic right ventricular cardiomyopathy.arrhythmogenic right ventricular cardiomyopathy (arvc) is an important cause of sudden death in young adults. on the basis of histopathological findings its pathogenesis may involve both a genetic origin and an inflammatory process. bartonella henselae may cause endomyocarditis and was detected in myocardium from a young male who succumbed to sudden cardiac death.200818666174
evaluation of an in-house cat scratch disease igm elisa to detect bartonella henselae in a routine laboratory setting.cat scratch disease (csd) is caused by bartonella henselae infection and is a common cause of regional lymphadenopathy. the diagnosis of csd largely depends on serology, but detection of b. henselae in an affected lymph node by pcr is also an important diagnostic tool. we evaluated an igm in-house elisa protocol and analyzed its performance in routine csd serology. serum samples from pcr-positive patients (n = 126), pcr-negative patients (n = 123), and age-matched controls (n = 126) were used fo ...200918679728
structure of the head of the bartonella adhesin bada.trimeric autotransporter adhesins (taas) are a major class of proteins by which pathogenic proteobacteria adhere to their hosts. prominent examples include yersinia yada, haemophilus hia and hsf, moraxella uspa1 and a2, and neisseria nada. taas also occur in symbiotic and environmental species and presumably represent a general solution to the problem of adhesion in proteobacteria. the general structure of taas follows a head-stalk-anchor architecture, where the heads are the primary mediators o ...200818688279
[bilateral panuveitis with serous retinal detachment].a 45-year-old patient with cat scratch disease presented with bilateral panuveitis as well as bilateral serous detachment of the retina. the patient had suffered from influenza with swollen lymph nodes 2 weeks previously.200918696078
[ocular bartonellosis in an hiv-hvc coinfected patient].bartonella henselae is the etiologic agent of the cat scratch disease and in immunocompromised patients, of bacillary angiomatosis and peliosis hepatis. less often, ocular complications associated with b. henselae infection have been reported in immunocompetent patients and five times in hiv-infected patients. we report the case of a 42-year-old woman, coinfected by hiv-hcv, presenting with cirrhosis, who owned a cat and was hospitalized for bilateral loss of visual acuity. ophthalmologic examin ...200818706780
failure to identify an association between serologic or molecular evidence of bartonella infection and idiopathic rhinitis in dogs.to determine whether infection with or exposure to bartonella spp was associated with idiopathic rhinitis in dogs.200818710315
bartonella endocarditis mimicking adult still's disease.we describe the case of a 39-year-old caucasian woman who was admitted to the university hospital of antwerp with a clinical picture suggestive of adult still's disease. even though a transoesophageal echocardiography showed endocarditis of the aortic valve, blood cultures remained negative. additional serological testing revealed a positive result for bartonella henselae. histology of the supraclavicular lymph node showed a reactive lymph node with a positive polymerase chain reaction (pcr) for ...200818714850
cat-scratch disease of the head and neck in a pediatric population: surgical indications and outcomes.to identify the presentation of pediatric patients with head and neck manifestations of cat-scratch disease, one of the most common causes of subacute or chronic lymphadenitis in children, and to determine surgical indications and outcomes.200818722212
p26-based serodiagnosis for bartonella spp. infection in cats.bartonella henselae p26 has been identified as an immunodominant antigen expressed during feline infection. we used antisera from cats experimentally infected with b. henselae (n = 6), b. clarridgeiae (n = 4), or b. koehlerae (n = 2) and from a sample of naturally infected cats (b. henselae, n = 34; b. clarridgeiae, n = 1) to evaluate recombinant p26 (rp26) as a serodiagnostic antigen. immunoblots using antisera from cats infected with b. henselae and b. clarridgeiae reacted strongly with rp26, ...200818724780
simultaneous presence of two different copies of the 16s rrna gene in bartonella henselae.bartonella henselae is an emerging pathogen of increasing medical significance. previous investigations have revealed two different 16s rrna gene variants among b. henselae isolates, resulting in delineation of the b. henselae population into 16s rna type i and type ii isolates. while studying 191 b. henselae isolates by multi-locus sequence typing (mlst) we detected three isolates that could not be assigned to a distinct 16s rna type upon direct sequencing because of ambiguous nucleotides in a ...200818757822
prevalence of bartonella species antibodies and bartonella species dna in the blood of cats with and without fever.the purpose of this study was to determine whether there are associations between bartonella species antibody (enzyme-linked immunosorbent assay (elisa) and western blot (wb)) and polymerase chain reaction assay results in cats with and without fever. afebrile control cats (39/93; 42.0%) were more likely to have bartonella species antibodies than cats with fever (29/93; 31.2%). the difference in prevalence of bartonella species deoxyribonucleic acid (dna) in blood of cats with fever (14/81; 17.3 ...200918760647
[cat scratch disease: a diagnosis to be aware of!].subacute cervical lymphadenopathy among young adults may be of an infectious or malignant aetiology. we report two cases of young males with chronic cervical lymphadenopathy. a diagnosis of cat scratch disease (csd) was made by serological and molecular studies. csd is one of the most frequent infectious lymphadenopathies among young people. diagnosis of csd is dependent on clinical, epidemiological, molecular and histological criteria. the detection of antibodies to bartonella henselae and the ...200818777770
neuroretinitis secondary to concurrent infection with cat scratch disease and lyme disease. 200918791545
microbial culture of blood samples and serologic testing for bartonellosis in cats with chronic rhinosinusitis.to assess the role of bartonella spp in chronic rhinosinusitis (crs) by determining detection rates for the organism by serologic testing and microbial culture of blood samples for bartonella spp in cats with crs and control cats (cats with other nasal diseases, cats with systemic illnesses, and healthy cats).200818828717
[the diagnosis of cat-scratch-disease-associated adenitis: diagnostic value of serology and polymerase chain reaction].the diagnosis of cat scratch disease (csd) associated adenitis relies classically on the association of clinical, epidemiological and bacteriological criteria. the polymerase chain reaction (pcr) looks like a more competitive diagnostic trial than serology. we evaluated the sensitivity, specificity and predictive positive and negative values of serology in routine diagnosis of csd. a retrospective study over five years was led among patients presenting a suspicion of csd and having a serology an ...200818842353
cat scratch disease presenting as acute encephalopathy.an unusual case of primary meningo-encephalitis followed by partial complex seizure in a 9-year-old boy was found to be a symptom of cerebral bartonella henselae infection or cat scratch disease. despite one clinical relapse at 4 weeks post-presentation, he remained seizure free on carbamazepine for one year. six months after stopping carbamazepine, however, he developed deja vu phenomena and absence seizures with eeg abnormality. restarting carbamazepine improved his symptoms.200818843081
bartonella henselae survives after the storage period of red blood cell units: is it transmissible by transfusion?bartonella henselae is the agent of cat scratch disease and bacillary angiomatosis. blood donors can be asymptomatic carriers of b. henselae and the risk for transmission by transfusion should be considered. the objective of this study was to demonstrate that b. henselae remains viable in red blood cell (rbc) units at the end of the storage period. two rbc units were split into two portions. one portion was inoculated with b. henselae and the other was used as a control. all units were stored at ...200818937735
bartonella henselae in captive and hunter-harvested beluga (delphinapterus leucas).previously, we reported the isolation of bartonella henselae from the blood of harbor porpoises (phocoena phocoena) and loggerhead sea turtles (caretta caretta) from the north carolina coast. hematologic, pathologic, and microbiologic findings surrounding the death of a juvenile captive beluga in vancouver initiated an outbreak investigation designed to define the molecular prevalence of bartonella infection in belugas. using polymerase chain reaction analyses targeting the intergenic spacer reg ...200818957643
investigation of bartonella henselae in cats in ankara, turkey.the purpose of this study was to determine bartonella henselae prevalance in cats in ankara. whole bloods and sera collected from 256 cats were investigated for the presence feline bartonella species by culture and sera were tested for the presence of antibodies against b. henselae igg using immunofluorescence assay. bartonella species were isolated by blood culture from 24 (9.4%) cats. bartonella isolates were subjected to restriction fragment length polymorphism (rflp) by using taqi and hhai e ...200918990198
bartonella henselae: subversion of vascular endothelial cell functions by translocated bacterial effector proteins.bartonella henselae (bh) is a worldwide distributed zoonotic pathogen. depending on the immune status of the infected individual this bacterium can cause a wide spectrum of clinical manifestations, ranging from cat scratch disease (csd) to bacillary angiomatosis (ba) and bacillary peliosis (bp). ba and bp are characterized by tumor-like lesions at the skin or in the inner organs, respectively. these structures display pathological sprouting of capillaries with enlarged and hyperproliferated vasc ...200919010441
pcr detection of bartonella bovis and bartonella henselae in the blood of beef cattle.although an organism primarily associated with non-clinical bacteremia in domestic cattle and wild ruminants, bartonella bovis was recently defined as a cause of bovine endocarditis. the purpose of this study was to develop a b. bovis species-specific pcr assay that could be used to confirm the molecular prevalence of bartonella spp. infection. blood samples from 142 cattle were tested by conventional pcr targeting the bartonella 16s-23s intergenic spacer (its) region. overall, bartonella dna wa ...200919019574
hemoplasma infection in hiv-positive patient, brazil.hemotrophic mycoplasmas infect a variety of mammals. although infection in humans is rarely reported, an association with an immunocompromised state has been suggested. we report a case of a mycoplasma haemofelis-like infection in an hiv-positive patient co-infected with bartonella henselae.200819046522
bartonella henselae antibodies after cat bite. 200819046527
development of an immunoglobulin m capture-based enzyme-linked immunosorbent assay for diagnosis of acute infections with bartonella henselae.we describe the development of an immunoglobulin m-specific enzyme-linked immunosorbent assay for the detection of an early antibody response to bartonella henselae, the causative agent of cat scratch disease, bacillary angiomatosis, and endocarditis. this assay discriminates between b. henselae-positive and -negative patient samples with sensitivity and specificity values of 100% and 97.1%, respectively.200919052161
cat scratch disease with encephalopathy in a 9-year-old girl. 200819067901
multiplexed whole bacterial antigen microarray, a new format for the automation of serodiagnosis: the culture-negative endocarditis paradigm.the serological diagnosis of blood culture-negative endocarditis due to coxiella burnetii, bartonella spp., brucella melitensis and legionella pneumophila is based on a manual immunofluorescence assay (ifa), which is taken to be the reference method. the automated ifa inodiag multiplexed antigenic microarray, which includes a slide with all the above bacteria and four internal controls, an incubator, a fluorescent reader and software with an algorithm of interpretation for infectious endocarditi ...200819076842
the prevalence of bartonella, hemoplasma, and rickettsia felis infections in domestic cats and in cat fleas in ontario.the prevalence of persistent bacteremic bartonella spp. and hemoplasma infections was determined in healthy pet cats in ontario. blood samples from healthy cats sent to a diagnostic laboratory for routine health assessment over the course of 1 y were tested for bartonella spp. using both polymerase chain reaction (pcr) and blood culture, and for the presence of hemoplasma by pcr. the overall prevalence of bartonella spp. by pcr and by culture combined was 4.3% (28/646) [3.7% (24/646) bartonella ...200819086373
myocarditis due to bartonella henselae. 200819088543
[infective endocarditis due to bartonella henselae following a rupture of a cerebral aneurysm].we report a case of severe aortic bicuspid valve endocarditis, revealed by global cardiac failure without fever, in a 38-year-old man who had developed cerebral mycotic aneurysms nine months earlier. pcr analysis of the excised aortic valve and serological tests (even 9 months earlier) were positive for bartonella henselae. a combination of intravenous then oral doxycyclin at 200mg/day and intravenous gentamycin at 90mg/day was given for 6 and 2 weeks respectively. the evolution was favorable on ...200919097835
isolation of candidatus bartonella melophagi from human blood.candidatus bartonella melophagi was isolated by blood culture from 2 women, 1 of whom was co-infected with b. henselae. partial 16s rrna, rna polymerase b, and citrate synthase genes and 16s-23s internal transcribed spacer sequences indicated that human isolates were similar to candidatus b. melophagi.200919116054
evaluation of immunohistochemistry in identifying bartonella henselae in cat-scratch disease.cat-scratch disease (csd) is largely due to infection with bartonella henselae. microbiologic detection is difficult, and molecular testing is not readily available. a monoclonal antibody (mab) to b henselae has become commercially available. we evaluated the usefulness of immunohistochemical analysis (ihc) for diagnosing csd on surgical specimens and compared these results with polymerase chain reaction (pcr) detection and serologic testing for b henselae. we studied 24 formalin-fixed, paraffin ...200919141385
delayed exposure to infections and childhood lymphomas: a case-control study.delayed exposure to common infections during childhood, have been implied to cause strong immunological response to a single infectious agent that eventually triggers leukemogenesis. the aim of the present study was to investigate whether decreased exposure to infections, as reflected in a more seronegative spectrum to several common infectious agents, is associated with increased risk for the development of childhood lymphomas.200919169895
isolation or molecular detection of bartonella henselae and bartonella vinsonii subsp. berkhoffii from dogs with idiopathic cavitary effusions. 200919175739
back pain in a child caused by cat scratch disease. 200919209087
[prevalence igg antibodies against bartonella henselae in children with lymphadenopathy].bartonella henselae is a cat scratch disease's etiological agent which is usually manifestated as regional lymphadenopathy. in differential diagnosis of lymphadenopathy infections about etiology b. henselae are rarely taken into consideration. enlargement of lymph nodes observed in children more often than in adults are caused by bacterial, virus or parasitic factors. in this study immunoglobulines g class antibodies to b. henselae were determined among children with limphadenopathy. at 53 child ...200819209738
bartonellosis causing bilateral leber neuroretinitis: a case report.bartonella henselae is the causal agent of cat scratch disease and one variation in its presentation is leber neuroretinitis. the unilateral presence of exudation as a macular star and papilledema represent its most common presentation.200919253255
prevalence of bartonella henselae and bartonella clarridgeiae in cats and dogs in korea.blood, saliva, and nail samples were collected from 54 dogs and 151 cats and analyzed for the presence of bartonella henselae with a novel nested polymerase chain reaction (pcr) method. bartonella (b.) henselae was detected in feral cat blood (41.8%), saliva (44.1%), and nail (42.7%) samples. b. henselae was also detected in pet cat blood (33.3%), saliva (43.5%), and nail (29.5%) samples and in pet dog blood (16.6%), saliva (18.5%), and nail (29.6%) samples. nine samples were infected with b. cl ...200919255530
[clinical thinking and decision making in practice. a man with abdominal pain, weight loss and fever]. 200919256242
identification of bartonella henselae in an aborted equine fetus.this report describes the characterization of a bartonella henselae abortion in an equine fetus by gross, histologic, immunohistochemical, ultrastructural, and molecular methods. bartonella henselae can cause cat scratch disease, bacillary angiomatosis, bacillary peliosis, and endocarditis in humans and other animals. the bacterium has been isolated from several mammalian species but only recently from equids; however, it has not been linked to abortion in equids. an aborted equine fetus exhibit ...200919261640
prevalence of bartonella henselae antibodies in children and blood donors in croatia. 200919274430
ecological fitness and strategies of adaptation of bartonella species to their hosts and vectors.bartonella spp. are facultative intracellular bacteria that cause characteristic hostrestricted hemotropic infections in mammals and are typically transmitted by blood-sucking arthropods. in the mammalian reservoir, these bacteria initially infect a yet unrecognized primary niche, which seeds organisms into the blood stream leading to the establishment of a long-lasting intra-erythrocytic bacteremia as the hall-mark of infection. bacterial type iv secretion systems, which are supra-molecular tra ...200919284965
bacillary angiomatosis.an infection with bartonella henselae transmitted from domestic cats to humans by scratching normally leads to cat-scratch disease. when the human host has severe immunosuppression or hiv infection, the potentially life-threatening disease bacillary angiomatosis can develop. a 79-year-old man presented with livid-erythematous, angioma-like skin lesions. we considered a cutaneous infiltrate from his known chronic lymphocytic leukemia, merkel cell carcinoma, cutaneous metastases of internal tumors ...200919298547
a translocated protein of bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome.bartonella henselae enters human endothelial cells (ecs) by two alternative routes: either by endocytosis, giving rise to bartonella-containing vacuoles or by invasome-mediated internalization. only the latter process depends on the type iv secretion system virb/vird4 and involves the formation of cell surface-associated bacterial aggregates, which get engulfed by ec membranes in an f-actin-dependent manner, eventually resulting in their complete internalization. here, we report that among the v ...200919302579
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