| on the amino acids involved in the atpase site of mitochondrial f1 and the implication of the subunit c. | | 1979 | 35100 |
| kinetics and mechanism of action of aldehyde reductase from pig kidney. | an improved procedure for purifying aldehyde reductase is described. utilization of blue dextran--sepharose 4b and elimination of hydroxyapatite chromatography greatly improves the yield and ease of purification. starting with 340 g of kidney tissue (two pig kidneys) approx. 50 mg of purified reductase may be routinely and reproducibly obtained. the purified reductase was used to establish the kinetic reaction mechanism of the enzyme. initial-velocity analysis and product-inhibition data reveale ... | 1979 | 35157 |
| the pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene. | | 1978 | 35171 |
| [comparative study on the effects of alprenolol, bunitrolol, ethaverine, oxprenolol, papaverine, practolol, pindolol, pronethalol, propranolol, toliprolol and verapamil on cardiac and bronchial beta-receptors (author's transl)]. | | 1978 | 35172 |
| pharmacological studies on cs-430, a new psychotropic agent. | 10-bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5h)-one (cs-430) is a new psychotropic drug and has the following properties. the compound showed sleep-inducing effect at both 0.2 and 5 mg/kg (p.o.) in cynomolgus monkeys or at 3 mg/kg (p.o.) in rats. cs-430 showed selective conflict attenuating in rats or anticonvulsant effects in mice. furthermore, cs-430 blocked non-discriminated (sidman) avoidance response without severe impairment of the motor function bu ... | 1978 | 35173 |
| toxicology of clobazam. | 1 extensive toxicological investigations of clobazam are summarized. 2 ld50 values after oral administration ranged from 100 mg/kg in the dog to 6000 mg/kg in the rat. 3 long-term repeated dose studies have shown withdrawal effects in the dog and monkey (notably convulsions leading to death), similar to those known to occur with other benzodiazepines. 4 it is concluded that the overall safety and tolerability of clobazam have been demonstrated in the preclinical animal studies. | 1979 | 35202 |
| inactive 3-hydroxy-3-methylglutaryl-coenzyme a reductase in broken cell preparations of various mammalian tissues and cell cultures. | preincubation of broken cell preparations from a variety of tissues and cell cultures resulted in an apparent increase in the level of 3-hydroxy-3-methylglutaryl-coa reductase activity. however, apparent activation of the reductase in mouse liver, hepatomas and primary liver cell cultures was attributed largely to the loss, during the preincubation period, of an interfering enzyme, 3-hydroxy-3-methylglutaryl-coa lyase. among non hepatic cells and tissues (which did not contain appreciable lyase ... | 1979 | 35236 |
| the effect of beta-adrenoceptor and ca2+ antagonist drugs on the hypoxia-induced increased in resting tension. | using isolated, langendorff-perfused, electrically-paced guinea-pig hearts, we have investigated the rise in resting tension that occurs when mammalian heart muscle becomes hypoxic. substrate-depletion, tachycardia, hyperthyroidism, and inotropic interventions (ouabain, isoprenaline, and beta-receptor antagonists at concentrations which increase inotropic state) enhanced the rate of development of this increase in resting tension. 3.86 mumol.litre-1 propranolol, 0.22 to 2.20 mumol.litre-1 verapa ... | 1978 | 35282 |
| diastereoisomeric glucuronides of oxazepam. isolation and stereoselective enzymic hydrolysis. | oxazepam glucuronide isolated from swine urine by previously published methods was separated into its diastereoisomers by ion-exchange chromatography on a preparative scale. quantitative high-performance liquid chromatography was used to monitor the separation. the two isomers were obtained in analytically pure form and then characterized by elemental analysis, oxazepam content, mass spectrometry, ultraviolet spectroscopy, optical rotation and optical rotatory dispersion-circular dichroism. the ... | 1979 | 35325 |
| the insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself. | | 1979 | 35339 |
| nutrition and somatomedin. v. action and measurement of somatomedin inhibitor(s) in serum from diabetic rats. | serum from normal rats stimulates growth cartilage in vitro; this stimulation is attributed to somatomedin activity. in contrast, serum from diabetic rats may produce dose-response lines with negative slopes and, in combination studies, suppress the stimulatory activity of serum from normal rats; this is attributed to somatomedin inhibitory factor(s). somatomedin inhibitory activity in serum from diabetic rats cannot be attributed to recognized catabolic factors, such as glucocorticoids or free ... | 1979 | 35341 |
| diet as a modulator of aging and longevity. | the interrelationships between diet and life span are reviewed, with emphasis on results obtained in studies with experimental animals. ad libitum feeding throughout life does not promote maximal survival and food restriction increases mean life span. the possible importance of total energy, carbohydrate, and protein intake are considered, as well as the influence of mode of feeding. a number of mechanisms that might explain how nutrition affects life span are discussed, including disease patter ... | 1979 | 35376 |
| eosinophil chemotactic factor. release from human polymorphonuclear neutrophils by arachidonic acid. | an eosinophil chemotactic factor (ecf) can be released from human polymorphonuclear neutrophils by arachidonic acid (aa), its methyl ester, but not by other derivatives such as aa ethyl ester and arachidonyl acetate. the ecf is highly specific for eosinophils and does not attract polymorphonuclear neutrophils. a dose-dependent non-cytotoxic ecf release induced by aa can be obtained from human polymorphonuclear neutrophils from a lymphocyte-monocyte-basophil suspension, from rat basophil leukemia ... | 1979 | 35469 |
| a functional arginine residue in nadph-dependent aldehyde reductase from pig kidney. | pig kidney aldehyde reductase is inactivated by 2,3-butanedione, phenylglyoxal, methylglyoxal, and 1,2-cyclohexanedione. 2,3-butanedione caused the most rapid loss in enzyme activity, the rate of loss being proportional to the concentration of 2,3-butanedione. neither d-glyceraldehyde nor pyridine 3-aldehyde, both substrates for this broadly specific enzyme, protected the enzyme from inactivation but 1 mm nadph or nadp completely prevented the loss of activity by 2,3-butanedione suggesting the i ... | 1979 | 35531 |
| isolation, properties, and regulation of a mitochondrial acyl coenzyme a thioesterase from pig heart. | | 1979 | 35538 |
| characterization of macrophage agglutinating factor as a hyaluronic acid-protein complex. | | 1979 | 35610 |
| purification of uricase from mammalian tissue. | a simple, rapid procedure for the purification of uricase from mammalian tissue is reported. the procedure is based on the precipitation of mammalian uricase under certain dialysis conditions, and on its low solubility near neutral ph. exceptionally high yields of homogeneous enzyme are obtained. | 1979 | 35787 |
| [the synthesis and pharmacologic properties of n-alkylester homologs of d,1-2-phenylglycine]. | | 1978 | 35797 |
| the effect of bile acids on "solubilized" cholesterol 7 alpha-hydroxylase activity in swine. | optimal assay conditions for cholesterol 7 alpha-hydroxylase activity in swine liver microsomes were determined. the enzyme activity is induced three-fold by feeding cholestyramine to the swine. this suggests that cholesterol 7 alpha-hydroxylase is likely to be the rate-limiting enzyme for biosynthesis of bile acids in swine. the effects of various bile acids on cholesterol 7 alpha-hydroxylase in swine microsome and "solubilized" cholesterol 7 alpha-hydroxylase activity have been studied. there ... | 1979 | 35860 |
| the feeding habits and ecology of the tsetse fly glossina morsitans submorsitans newstead in relation to nagana transmission in the gambia. | the source of blood meals from 174 fed glossina morsitans submorsitans newstead, captured in malaise traps in savanna woodland in the gambia, were identified by the precipitin test. warthog accounted for 90% of the meals and single bushbuck and ox feeds were identified. nagana is a major problem in the area, but contact between tsetse and livestock is reduced by restricted grazing. in this situation, warthog, with a ubiquitous distribution, appear to be major maintenance hosts for g. m. submorsi ... | 1979 | 35933 |
| sikhote-alin virus, a new member of the cardiovirus group (picornaviridae) isolated from ixodes persulcatus ticks in primorie region. | a virus, designated sikhote-alin, was isolated in 1970 from ixodes persulcatus ticks collected from a wild boar in the primorie region (u.s.s.r.) sikhote-alin virus showed no haemagglutinating activity and no antigenic relationships with arboviruses of 12 antigenic groups, 17 ungrouped tick-borne arboviruses, porcine enteroviruses and coxsackie a (types 1-18) viruses. an one-way antigenic relationship was demonstrated by complement fixation with cardioviruses (mengo and columbia-sk strains). the ... | 1978 | 35943 |
| a detailed investigation of the properties of lactate dehydrogenase in which the 'essential' cysteine-165 is modified by thioalkylation. | the reaction of pig heart lactate dehydrogenase with methyl methanethiosulphonate resulted in the modification of one thiol group per protomer, and this was located at cysteine-165 in the enzyme sequence. on reduction, both the thiomethylation of cysteine-165 and any changes in kinetic properties of the enzyme were completely reversed. cysteine-165 has been considered essential for catalytic activity; however, cysteine-165-thiomethylated dehydrogenase possessed full catalytic activity, although ... | 1979 | 36072 |
| [in vitro method for estimation of enteral absorption of clanobutin and other drugs]. | two models have been developed for the determination of in vitro absorption of 4-[4-chloro-n-(4-methoxyphenyl)-benzamidol]-butyric acid (clanobutin) and other agents. permeability coefficients pm are obtained on artificial phospholipid collodion membranes which permit calculation of absorption coefficients k1 for anticipated human enteral absorption with consideration of physiological parameters. at a ph of 7--8 (small intestine) in particular, k1 shows good agreement with in vitro absorption de ... | 1979 | 36106 |
| affinity purification and properties of porcine brain aldose reductase. | aldose reductase (alditol:nadp+ 1-oxidoreductase, ec 1.1.1.21) has been purified 1500-fold from porcine brain in a four-step procedure employing blue-sepharose 6b affinity chromatography. the purified enzyme was shown to be apparently homogeneous by polyacrylamide gel electrophoresis. the enzyme is a single chain polypeptide of molecular weight 40 000, ph optimum 5.0 k(app)(xylose) 4 mm; k(app)(nadph) 3 microm. the relative substrate activities, activation with sulfate ion, and limited oxidative ... | 1979 | 36151 |
| luminal alkalinization by guinea-pig cecum in vitro, an electro-neutral process. | guinea-pig cecum was found to alkalinize its mucosal media in vitro at a chemical equivalents rate greater than the short circuit current (isc). alkalinization was inhibited by conditions which did not affect isc and by low mucosal na suggesting an electro--neutral process, dependent on na. | 1979 | 36288 |
| effects of adrenergic and cholinergic agonists on adenylate and guanylate cyclase activity of isolated guinea-pig seminal vesicle epithelium. | isolated seminal vesicle epithelium of the guinea-pig contained increased amounts of camp and cgmp after treatment with pge1 and carbachol, respectively. adrenergic agents had no influence. possible physiological implications of these results are discussed. | 1979 | 36292 |
| retention of biologic characteristics of zona pellucida in highly concentrated salt solution: the use of salt-stored eggs for assessing the fertilizing capacity of spermatozoa. | when unfertilized hamster eggs are placed in highly concentrated solutions of neutral salts (e.g., 2 m ammonium sulfate), the egg proper, or vitellus, shrinks, creating a large perivitelline space; the zona pellucida remains unchanged in appearance under the light microscope. when these eggs are inseminated, many spermatozoa attach to and penetrate the zona. the specificity as well as several physical and chemical characteristics of the zona seem to remain unchanged during storage of the eggs in ... | 1979 | 36308 |
| studies on competitive inflammatory sites. i. influence of the size of sensitizing skin implants on second-set corneal graft reactions. | a dependence of second-set corneal graft reactions on the size of the sensitizing skin allografts was established in different rat donor-recipient pairs, each of which involved a response to the b2 major histocompatibility antigen. sensitizing skin sizes larger or smaller than the optimal size were found to result in less intense reaction in subsequently placed second-set corneal allografts. the data obtained support the view that a persisting skin allograft not only sensitizes, but constitutes ... | 1979 | 36350 |
| studies on competitive inflammatory sites. ii. depression of second-set corneal allograft reactions by allogeneic and xenogeneic skin implantation. | | 1979 | 36351 |
| reactions of pig heart lipoamide dehydrogenase with pyridine nucleotides. evidence for an effector role for bound oxidized pyridine nucleotide. | | 1979 | 36378 |
| the liver microsomal fad-containing monooxygenase. spectral characterization and kinetic studies. | a fad-containing monooxygenase isolated from pig liver microsomes migrates as a single band upon electrophoresis in polyacrylamide gels in the presence of dodecyl sulfate. the minimum molecular weight based on mass of amino acids per mole of flavin is 64,000. however, the catalytically active enzyme exists as aggregating units of the monomer. neither oxygen nor organic substrates perturbed the spectrum of the oxidized flavoprotein and their binding to this form of the enzyme could not be detecte ... | 1979 | 36396 |
| histamine, h1 and h2 antihistamines, and immediate hypersensitivity reactions. | | 1979 | 36419 |
| two migration inhibitory factors differ in density and susceptibility to neuraminidase and proteinases. | | 1979 | 36431 |
| characterization of receptors on postganglionic cholinergic neurons in the guinea-pig isolated ileum. | dopamine, apomorphine, noradrenaline and isoprenaline reduced the response of the isolated guinea-pig ileum to exogenous acetylcholine by a maximum of 40%. propranolol reversed this inhibition whilst phentolamine and pimozide were ineffective, suggesting that the drugs were acting on a post-synaptic beta-adrenoceptor. the same agonists were more effective as inhibitors of the response to transmural electrical stimulation of the ileum, lower doses producing almost complete inhibition. this inhibi ... | 1979 | 36459 |
| effect of naloxone on the sensitivity of the vas deferens to various agonists. | the effect of naloxone in vitro, on noradrenaline (na)-induced responses in guinea-pig isolated vas deferens was studied. the responses of na were potentiated by naloxone (3 microm). it potentiated the responses to methoxamine which has least affinity for uptake sites. responses induced by acetylcholine and potassium chloride were also potentiated by naloxone. low calcium (0.8 mm) in the medium antagonized the potentiating action of naloxone. it is suggested that naloxone produces non-specific p ... | 1979 | 36460 |
| the effect of levamisole on the cardiac responses to sympathomimetics and on the amine uptake process. | | 1979 | 36470 |
| the influence of cyclic gmp on contractions of guinea-pig bronchial muscle. | | 1979 | 36475 |
| evidence that substance p does not mediate slow synaptic excitation within the myenteric plexus. | | 1979 | 36570 |
| proceedings eighty-second annual meeting of the united states animal health association. | | 1978 | 36629 |
| efficacy of pro-pam (n-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride) as a prophylaxis against organophosphate poisoning. | | 1979 | 36686 |
| synthetic analogues of nicotine. vii. acid dissociation constants of some nicotine analogues. | | 1979 | 36733 |
| effect of plasma h+-ion concentration on pancreatic hco-3 secretion. | the relationship between the rate of pancreatic hco-3 secretion and plasma h+-ion concentration was investigated in 15 pentothal anesthetized, secretin infused pigs (1.8 c.u./kg b.w. h-1, intravenously) during acute metabolic and respiratory acid-base disturbances. pancreatic hco-3 secretion increasd to 196 +/- 10% of control during alkalosis and fell to 41 +/- 4% of control during acidosis. partial metabolic compensation of respiratory acidosis restored hco-3 secretion to 87 +/- 6% of control. ... | 1979 | 36734 |
| [muscle meat quality studies in swine. 6. the effect of genetic structure and sex]. | | 1979 | 36862 |
| potassium-stimulated atpase activity and hydrogen transport in gastric microsomal vesicles. | the mg2+-dependent, k+-stimulated atpase of microsomes from pig gastric mucosa has been studied in relation to observed active h+ transport into vesicular space. uptake of fluorescent dyes (acridine orange and 9-aminoacridine) was used to monitor the generated ph gradient. freeze-fracture electron microscopy showed that the vesicular gastric microsomes have an asymmetric distribution of intramembraneous particles (p-face was particulate; e-face was relatively smooth. valinomycin stimulated both ... | 1979 | 36910 |
| histamine receptors on guinea-pig alveolar macrophages: chemical specificity and the effects of h1- and h2-receptor agonists and antagonists. | | 1979 | 37009 |
| cardiac glycosides in the defensive secretion of chrysolina herbacea (coleoptera, chrysomelidae). identification, biological role and pharmacological activity. | | 1979 | 37033 |
| effects of catecholamine treatment as well as cold exposure on mitochondrial enzyme activities of the adipose tissue in a guinea-pig (cavia porcellus). | | 1979 | 37034 |
| 1h nuclear-magnetic-resonance studies of porcine lutropin and its alpha and beta subunits. | the titration curves of the histidine residues of porcine lutropin and its isolated alpha and beta subunits have been determined by following the ph-dependence of the imidazole c-2 proton resonances. the isolated alpha subunit contains a buried histidine, whose c-2 proton does not exchange with solvent, and which has the unusually low pk of 3.3. in the native hormone all the histidine residues have relatively normal pk values (between 5.7 and 6.2). the four histidine c-2 proton resonances have b ... | 1979 | 37081 |
| salts- induced oxidase activity of lipoamide dehydrogenase from pig heart. | a weak nadh oxidase activity of lipoamide dehydrogenase at neutral ph is increased as much as 15-fold by the addition of ki or (nh4)2so4. the addition of nad+ shifts the optimum ph for the ki-induced oxidase activity from 6.3 to 5.5 without changing the maximum activity. the optimum ph is similarly shifted to 5.6 when sulfhyldryl groups of the enzyme are oxidized in the presence of small amount of cupric ion. the nadh: lipoamide and nadh: p-benzoquinone reductase activities are strongly inhibite ... | 1979 | 37086 |
| maldescended testis: consequences and attempted therapy in pigs. | | 1979 | 37186 |
| inhibition of guinea-pig brain tyrosine hydroxylase by catechols and biopterin. | | 1979 | 37286 |
| uptake of 5-hydroxytryptamine in blood platelets and its inhibition by drugs: role of plasma membrane and granular storage. | the initial uptake of 3h-5-hydroxytryptamine (3h-5-ht) showed linearity for short time intervals in normal and reserpinized blood platelets of guinea-pigs, but was lower in reserpinized platelets. teh km values for the 3h-5-ht uptake were virtually identical in normal and reserpinized platelets, whereas vmax was lower in the latter. imipramine and chlorpromazine caused the same percentage inhibition of 3h-5-ht uptake in normal and reserpinized platelets; the reserpine-like compound ro 4-1284 inh ... | 1979 | 37296 |
| the reversal by pyridostigmine of neuromuscular block produced by soman. | the effect of pyridostigmine on neuromuscular block produced by soman was studied in the isolated phrenic nerve-diaphragm preparation. in the rat, soman produced an irreversible reduction in tetanic tension and functional acetylcholinesterase (ache) activity. pretreatment with pyridostigmine before exposure of the diaphragm to soman, followed by removal of the anticholinesterase from the organ bath, produced a return of tetanic tension and an increase of 5% in functional ache activity. similar r ... | 1979 | 37297 |
| comparative metabolism of codeine in man, rat, dog, guinea-pig and rabbit: identification of four new metabolites. | the metabolism and excretion of codeine and its metabolites in untreated urine of man, rat, dog, guinea-pig and rabbit have been examined. metabolites were identified by gas chromatography mass spectrometry operated in the chemical ionization mode (methane). concentrations of codeine and metabolites were measured by selected ion monitoring. both codeine and norcodeine were detected in the urine of all species but a new metabolite, hydrocodone, was found only in the urine from man, guinea-pig and ... | 1979 | 37301 |
| 31p nuclear magnetic resonance measurement of cardiac ph in perfused guinea-pig hearts. | | 1979 | 37345 |
| the influence of ph on the ca2+-regulated atpase of cardiac and white skeletal myofibrils. | | 1979 | 37346 |
| reconstitution of atp synthetase on a collagen membrane that can synthesize atp using a ph gradient. | | 1979 | 37408 |
| [ph-dependence of the structural and functional properties of lactate dehydrogenase (m4). indirect cooperativity in lactate dehydrogenase]. | the dependence of structural and functional properties of ldh on ph in the 6.0--9.0 region was investigated. there were no marked deviations of pyruvate reduction initial velocity curves from the michaelis--menten equation in a wide range of pyruvate concentrations. it was shown that vmax changes negligibly in the 6.0--9.0 ph regions, but km increased markedly with ph elevation. the pk value of 7.8+/-0.1 was obtained for 50% changes of pyruvate binding. the dependence of enzyme inhibition from p ... | 1977 | 37431 |
| reactions of cysteamine and other amine metabolites with glyoxylate and oxygen catalyzed by mammalian d-amino acid oxidase. | pig kidney d-amino acid oxidase [d-amino-acid:oxygen oxidoreductase (deaminating), ec 1.4.3.3] catalyzes a rapid uptake of oxygen when high concentrations (50-100 mm) of glyoxylate and the following amines are present under usual assay conditions (ph 8.3): cysteamine, 2-aminoethanol, putrescine, d,l-1-amino-2-propanol, d,l-2-amino-1-propanol, 3-amino-1-propanol, d,l-octopamine, ethylenediamine, and l-cysteine ethyl ester. notable physiological amines that do not support a rapid o2 reaction under ... | 1979 | 37501 |
| international committee communications. report from the subcommittee on heparin. | | 1979 | 37611 |
| histamine receptors mediating cyclic amp accumulation in slices from guinea-pig hippocampus: characterization and localization [proceedings]. | | 1979 | 37727 |
| a critique of the u.s. standard for industrial exposure to sodium hydroxide aerosols. | published studies of the toxicity of sodium hydroxide aerosols are few. these studies were generally marred by inadequate characterization of particle size and chemical compositon and of the ambient humidity. because naoh aerosols can readily undergo reaction with carbon dioxide to form sodium carbonate, a much less alkaline (and less hygroscopic) compound, these shortcomings may warrant a reconsideration of the naoh standard and the consideration of a na2co3 standard. | 1979 | 37730 |
| a simplified procedure for the isolation of pig kidney d-amino acid oxidase. | | 1979 | 37777 |
| measurement of renin and substrate concentrations in human serum. | | 1979 | 37778 |
| the epidermal helix: a model for the bilayer couple phenomenon. | narrow strips of isolated epidermis rapidly assume a helical conformation when placed in a dilute hypotonic aqueous solution of histamine as a free base. the same belical formations could be induced by dilute hypotonic solutions of alkalis or acids. this coiling resulted from damage to the malpighian cells, with consequent asymmetric osmotic swelling of the epidermis, thus producing torsional forces on the stratum corneum. in essence, the epidermal helix proved to be a ph dependent, osmotically ... | 1979 | 37808 |
| the alkaline transition of swine pepsinogen. | at alkaline ph, swine pepsinogen is reversibly inactivated in a transition which involves the cooperative release of two protons from the molecule and is governed by a pk = 9. stopped flow kinetic studies on the absorbance changes accompanying this reaction show that it can be resolved into two steps, with increasing ph; a slow conformational change, whose amplitude follows the ionisation curve of one group of pk = 9.9, followed by a rapid ph dependent conformational change, linked to a group of ... | 1979 | 37936 |
| the inhibitory effects of presynaptic alpha-adrenoceptor agonists on contractions of guinea-pig ileum and mouse vas deferens in the morphine-dependent and withdrawn states produced in vitro. | 1 isolated ilea from guinea-pigs implanted with morphine pellets were stimulated coaxially, either with or without morphine present in the bath fluid, and the longitudinal contractions recorded. 2 in the absence of morphine the inhibitory effects of the presynaptic alpha-adrenoceptor agonists, clonidine and oxymetazoline were much reduced and the dose-response curve was flat. this state of 'withdrawal' was readily reversed by morphine and levorphanol but not its inactive (+)-isomer, dextrophan. ... | 1979 | 37965 |
| dendro axonic neurotransmission. ii. morphological sites for the synthesis, binding and release of neurotransmitters in dopaminergic dendrites in the substantia nigra and cholinergic dendrites in the neostriatum. | morphological evidence is presented indicating sites of synthesis, storage, and release of neurotransmitters in dendrites of dopaminergic cells of the substantia nigra and cholinergic cells of the neostriatum. smooth endoplasmic reticulum can be identified in dopaminergic neurons touching the dendritic surface. the false transmitter for dopamine, 5-hydroxydopamine (5-ohda), is localized to smooth endoplasmic reticulum or large vesicular structures which approach the dendritic surface. the dopami ... | 1979 | 37984 |
| alpha- and beta-adrenergic mechanisms in the aorta of newborn rabbits and guinea-pigs. | | 1979 | 38184 |
| on the optimization of local hyperthermy in tumors based on a new radiofrequency procedure. local hyperthermy of large body areas using the cmt selectotherm method. | a new radiofrequency procedure, i.c., the cmt selectotherm technique, permits to convey large heat quantities per volume unit also to deep-seated tumor tissues without causing thermal lesions in healthy tissues near or at the body surface. the improved spatial homogeneity of energy supply attainable by this method is demonstrated by measurements at a gelatine phantom and, in particular, by in vivo measurements on pigs. the appliability of local hyperthermy to tumors localized in different parts ... | 1979 | 38255 |
| evidence for an ester linkage between the labile binding site of c3b and receptive surfaces. | | 1979 | 38283 |
| allergic encephalitis, rabies antibodies, and the blood/brain barrier. | similarity of the syndromes of rabies and of encephalomyelitis resulting from rabies vaccination poses a problem in differential diagnosis that has had tragic consequences. that difficulty may also be largely responsible for the traditional belief that rabies is inexorably fatal, in that recovery from paralysis is interpreted as evidence that the disease was postvaccinal encephalomyelitis rather than rabies. diagnosis is additionally complicated by presence of rabies antibodies in serum in both ... | 1979 | 38289 |
| mechanism of phenothiazine inhibition of ca2+-dependent guanosine 3',5'-(cyclic) monophosphate phosphodiesterase of brain. | | 1979 | 38390 |
| mechanism of the nucleotide pyrophosphatase induced distortion of stoichiometry of tpnh utilization and product formation by hepatic cytochrome p-450 linked n-demethylase systems. | | 1979 | 38393 |
| substance p: model studies of its binding to phospholipids. | 1. the partition of substance p (sp) between buffer solutions (ph 1.6--7.8) and an organic, phospholipid (phosphatidyl serine, phosphatidyl ethanolamine, phosphatidyl inositol and phosphatidyl choline) containing phase (chloroform:methanol 2:1) was studied. 2. the binding of sp to phosphatidyl serine, phosphatidyl ethanolamine and phosphatidyl inositol was lowest at ph 2 and increased with ph. the binding to phosphatidyl choline was much smaller and less dependent on ph. 3. in contrast to the ba ... | 1979 | 38406 |
| in vitro study of phenothiazine effects on urinary bladder. | clinical observations suggest that long-term phenothiazine therapy can cause urinary retention and stress incontinence. the phenothiazines, chlorpromazine and perchlorperazine, depress bladder smooth muscle activity in vitro by depressing bladder smooth muscle activity directly and by a peripheral cholinergic blocking action. | 1979 | 38553 |
| [changes in the electrical conductance of the blood in irradiated animals]. | | 1979 | 38595 |
| studies on the pharmacokinetic function of the lung with special reference to lidocaine. | | 1979 | 38621 |
| abstracts of the lectures delivered at the 42nd congress of the hungarian physiological society, budapest, june 10--12, 1976. | | 1978 | 38631 |
| [experimental hepatic ischemia]. | total clamping of the hepatic pedicle was performed for a period of two hours in the normothermic pig. during this time an external pulsed spleno-jugular shunt ensured effective-portal decompression. under such conditions, the biological and histological consequences of this ischaemia were minimal and perfectly compatible with survival. this would suggest that the clinical syndrome of "shock liver" above all reflects splanchnic impairment. | 1979 | 38702 |
| [meeting of the french society of microbiology. paris, october 12, 1978. abstracts]. | | 1979 | 38723 |
| kinetic properties of pig pyruvate kinases type a from kidney and type m from muscle. | | 1979 | 38749 |
| the catalytic activity of pig pepsin c towards small synthetic substrates. | a series of small peptides has been synthesized and used to investigate the activity of a minor pig pepsin, pepsin c (ec 3.4.23.3). the peptides had the general formula a-leu-val-his-b. b was either ome, nh2 or oh. with b = nh2 hydrolysis (kcat./km) at 37 degrees c and ph 2.07 increased as a was ac-ala, ac-tyr, ac-phe and ac-ala-phe. the ph dependence of the hydrolysis of ac-phe-leu-val-his-nh2 indicated the apparent pka values of two catalytically important groups on the enzyme as 1.42 and 4.88 ... | 1979 | 38772 |
| dissociation and reassociation of creatine kinase with heart mitochondria; ph and phosphate dependence. | | 1979 | 38786 |
| general pharmacology of amitriptylinoxide. | | 1978 | 38803 |
| regulation of the interaction of pancreatic phospholipase a2 with lipid-water interfaces by ca2+ ions: a monolayer study. | | 1979 | 38829 |
| comparative studies of tyrosine modification in pancreatic phospholipases. 2. properties of the nitrotyrosyl, aminotyrosyl, and dansylaminotyrosyl derivatives of pig, horse, and ox phospholipases a2 and their zymogens. | | 1979 | 38834 |
| studies on the effect of acute asphyxia on the fetal pig in utero. | 8 term fetal pigs (110-112 days gestation) and one 97-day fetus were asphyxiated in utero by occlusion of the umbilical cord. mean times to last gasp and last heart beat were 5.1 and 22.4 for term and 5.4 and 30.4 min for the 97-day fetus. cord occlusion was followed by profound bradycardia and an increase in blood pressure which was maintained until gasping ceased. profound acidemia, hypercapnia and hyperlactacidemia developed in all animals and values following asphyxiation were comparable wit ... | 1979 | 38863 |
| a genetic study of cryptorchidism and scrotal hernia in pigs. | the genetic parameters of cryptorchidism and scrotal hernia were estimated. the heritability of liability to cryptorchidism identified at birth was about 0.5 and that identified to be normal at birth, but recognized to be abnormal later was almost zero. the heritabilities of scrotal hernia estimated in two herds were 0.65 and 0.86. the genetic correlation between these two defects was 0.20. an equation for calculating selection differentials for family selection was derived and expected changes ... | 1979 | 38893 |
| influence of angiotensin ii, ouabain and hydrostatic pressure on inulin and electrolyte concentration of fluid perfusing pig carotid arteries in vitro. | | 1979 | 38933 |
| l-azaserine toxicity in established cell lines: correlation with gamma-glutamyl transpeptidase activity. | | 1979 | 38980 |
| vasoactive intestinal polypeptide: measurement, distribution and putative neurotransmitter function. | vasoactive intestinal polypeptide (vip) is a highly basic octacosapeptide isolated from porcine small intestine. vip was originally considered to be a gut hormone, but radioimmunochemical and immunohistochemical studies have revealed that vip has a widespread distribution localized in neurons. vip-containing neurons are present in the central nervous system including the cerebral arteries, the digestive tract, the genitourinary tract and the adrenal glands. in the nerve terminals vip is localize ... | 1979 | 39014 |
| determination of virginiamycin in feeds. | virginiamycin was extracted from the feed by ethanol-ph 2.5 phosphate buffer (1 + 1). the ph during extraction was adjusted (when necessary) to between 4 and 5. sample dilutions and the standard dose response line were prepared to contain ethanol ph 6 phosphate buffer (2 + 8), and the test organism was sarcina lutea. three feeds (a poultry ration, a swine finishing ration, and a swine starter ration) showed virginiamycin recovery of 88.8--108.9% when standard solutions were added at concentratio ... | 1979 | 39060 |
| effects of the non-steroidal anti-inflammatory drug benoxaprofen on leucocyte migration. | possible modes of action of the anti-inflammatory drug, benoxaprofen, have been explored. the drug caused inhibition of leucocyte migration, principally of mononuclear cells into the pleural cavity of rats undergoing carrageenan-induced pleurisy. evidence was obtained from in vitro leucocyte migration and chemotaxis models that the drug acted directly on the mononuclear cells rather than by inhibition of chemotactic factors. | 1979 | 39133 |
| effect of secretin on histamine-induced duodenal ulceration in guinea-pigs. | | 1979 | 39144 |
| effect of antiarrhythmic and analgesic drugs on the effective refractory period of guinea-pig isolated atria and ventricular strips. | | 1979 | 39146 |
| ascorbic acid modulation of splenic cell cyclic gmp metabolism. | | 1979 | 39206 |
| [on the narco-hypnotic of o-chloro 2-phenyl ethyl allophanate (s. c. s. 100) in animal (author's transl)]. | oral administration of o-chloro 2-phenyl éthyl allophanate (s. c. s. 100) to male and pregnant, or not, female mice, to male and female rats, to male guinea-pigs and rabbits induces, according to tested doses and animal species, a reduction of motoricity, a state of sleepiness giving way to exterior solicitations, a loss of balance, a diminution of muscular tonus or a temporary loss of righting reflex going with narcosis and a reversible suppression of sensibility. the narco-hynoticaction of s. ... | 1979 | 39471 |
| beta-adrenergic blocking action of halonitrophenethanolamines. | a series of phenethanolamines with n-isopropyl and n-tertbutyl substituents and ring-substituted with nitro- and halogen groups has been prepared. using guinea-pig isolated atrial and tracheal preparations, the influence of the nitro-group on the beta 1- and beta 2-antagonist actions of the mono-halogen compounds was determined, and the antagonist and partial agonist effects of the halo-nitro-compounds on beta-adrenoceptors in these tissues measured to help elucidate structure-activity relations ... | 1979 | 39529 |
| effect of strophantin on the isolated guinea-pig ileum. | the effect of strophantin on isolated guinea-pig ileum was investigated. it was found that strophantin produces a dose-dependent contraction that is not blocked by atropine, ganglionic blockade, but is potentiated by prostigmine. depolarization of the guinea-pig ileum by a high potassium solution does not change the effect of strophantin. strophantin response is competitively antagonized by verapamil. the effect is significantly reduced, 5 to 10 min, after the preparation is immersed in zero cal ... | 1979 | 39531 |