| serum lipid and lipoprotein responses of six nonhuman primate species to dietary changes in cholesterol levels. | the response of serum lipids and lipoproteins to different levels of cholesterol in the diet was studied in chimpanzee (pan troglodytes), rhesus (macaca mulatta), green (cercopithecus aethiops), patas (erythrocebus patas), squirrel (saimiri sciurea) and spider (ateles sp.) monkeys. five animals of each species were fed increasing amounts of dietary cholesterol (0.05% to 1.5% w/w) for 3-week periods; between each experimental diet, the animals were fed a basal diet without cholesterol for a simil ... | 1976 | 186573 |
| dynamics of adenosine-3', 5'- monophosphate transfer among mother, fetus, and amniotic fluid in the rhesus monkey. | cyclic amp exchange among the mother, amniotic fluid, and fetus was studied in normal rhesus monkeys at term pregnancy. following a pulse intravenous administration of 3h-cyclic amp into the mother, a small fraction of the dose appeared in less than 1 minute in fetal blood. it appeared in the amniotic fluid after 5 minutes and reached maximum level in 20 minutes. the accumulation of 3h-cyclic amp in the amniotic fluid in 1 hour was 0.03 per cent of the injected dose. the amount and time course o ... | 1976 | 187058 |
| the effect of cholesterol feeding on primate serum lipoproteins. i. low density lipoprotein characterization from rhesus monkeys with high serum cholesterol. | | 1976 | 187177 |
| effect of adrenergic blockade and dexamethasone on the aldosterone response to brain stimulation in the rhesus monkey. | the increase in aldosterone and plasma renin activity (pra) observed after stimulation of extrahypothalamic sites within the brain of the rhesus monkey was prevented by the prior administration of the beta-adrenergic blocking agent propranolol. alpha-adrenergic blockade by phentolamine had no inhibiting effect. propranolol only partially reduced the response of aldosterone to lateral hypothalamic stimulation in spite of inhibition of pra; a partial reduction in aldosterone was also obtained from ... | 1976 | 187707 |
| sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey. | six young adult male rhesus monkeys were given diethylnitrosamine ip for 3-5 years. liver biospies were done monthly. after 6 months, biopsy specimens showed individual hepatocytes and small foci of hepatocytes that were intensely positive for glycogen. during the second and later years, larger foci of such cells developed. in sections stained with hematoxylin and eosin, the glycogen-containing hepatocytes generally appeared unusually clear. some hepatocytes, however, had eosinophilic or basophi ... | 1976 | 187798 |
| hyperreactive arterial endothelial cells: a clue for the treatment of atherosclerosis. | arterial endothelial cells, which are capable of phagocytizing carbon particles of the same size as beta- and pre-beta-lipoprotein, were found only in endothelial cells of arterial segments susceptible to atheromatous changes in susceptible animal species, and the distribution closely corresponded to the susceptibility. the distribution of such endothelial cells is dense in large arteries, in the openings to their branches, especially in downstream portions, of rabbits, hens, and cocks; however, ... | 1976 | 188368 |
| comparison of the serum low density lipoprotein and of its apoprotein in the pig, rhesus monkey and baboon with that in man. | the principal form of the serum low density lipoprotein (ldl) in man, baboon, rhesus monkey and pig was isolated by preparative ultracentrifugation in the density interval 1.024-1.045 g/ml. the physicochemical characteristics of pig ldl most closely resembled those of man; thus, electrophoretic studies suggested that both baboon and rhesus ldl have a greater surface charge than that of their human counterpart, and electron-microscopic investigations showed baboon ldl (245 a) to be larger and rhe ... | 1976 | 188432 |
| study of abnormal plasma low-density lipoprotein in rhesus monkeys with diet-induced hyperlipidemia. | male rhesus monkeys were divided into three groups: five were fed a regular primate chow diet and were used as controls; four received an "average" american diet; and five a special low-fat primate chow diet supplemented with 25% coconut oil and 2% cholesterol. in all of these animals, the plasma low-density lipoproteins (ldl) were isolated by ultracentrifugal flotation between densities of 1.019 and 1.050 g/ml. the ldl of the five control monkeys had variable molecular weights, with a mean valu ... | 1976 | 188443 |
| influence of lysophosphatidylcholine on the metabolism of plasma lipoproteins. | both low density lipoproteins and cellular membranes are known to have a high affinity for lysophosphatidylcholine. in this study lysophosphatidylcholine influenced the retention of lipoproteins by arterial tissue in vitro and the rate of disappearance of low density lipoproteins from the blood in vivo. pieces of aorta from rabbits or rhesus monkeys were successively incubated for 90 min each in 2 or 3 solutions. after the last incubation the intima plus inner media was dissected from the remain ... | 1976 | 188451 |
| plaque assay of neonatal calf diarrhea virus and the neutralizing antibody in human sera. | neonatal calf diarrhea virus (a bovine rotavirus) formed distinct plaques in monolayers of ma-104 cells, an established macacus rhesus monkey kidney cell line, when diethylaminoethyl dextran and trypsin were included in the overlay medium. by using this plaque assay method, titration of neutralizing antibody to neonatal calf diarrhea virus was made feasible. it was demonstrated that some human sera contained neutralizing antibody to this agent. | 1977 | 188863 |
| cortisol secretion and clearance in the rhesus monkey. | cortisol secretory patterns were studied in two chair-adapted rhesus monkeys by simultaneous measurement of plasma concentration and specific activity of cortisol after an iv bolus of 14c-labeled hormone. the results indicated that fluctuating plasma cortisol concentrations are the result of episodic secretion by the adrenal cortex. specific activity changes during these spontaneous secretory bursts indicated occasional submaximal activity. in addition, cortisol secretory rates calculated during ... | 1977 | 189992 |
| estrogen metabolism in nonhuman primates. i. in vitro biosynthesis of estrogen glucosiduronates in rhesus monkey liver. | estrone glucosiduronate, 17beta-estradiol-3-glucosiduronate, 17beta-estradiol-17-glucosiduronate and estriol-16alpha-glucosiduronate have been biosynthesized in substantial yield by incubation of radioactive estrone, 17beta-estradiol, estriol and uridine diphosphoglucosiduronic acid with rhesus monkey liver homogenates. the metabolites were characterized by chromatography on celite and deae-sephadex, enzyme hydrolysis, derivative formation and crystallization to constant specific activity. the p ... | 1977 | 190739 |
| [ultrastructural changes in the central nervous system of monkeys in poliomyelitis]. | the ultrastructure of cells of the central nervous system of rhesus monkeys in experimental poliomyelitis caused by virus of poliomyelitis type 3 was studied. it was found out that the virus of poliomyelitis was localized in nerve cells, astocytes, oligodendrocytes, the endothelium of capillaries and macrophages. this justifies the conclusion that pathological changes in the cells referred to the above result from reproduction of the virus therein. ultrastructural changes in infected cells are d ... | 1976 | 190980 |
| stimulation of cholesterol esterification in rhesus monkey arterial smooth muscle cells. | the influence of homologous high density lipoprotein (hdl) and low density lipoprotein (ldl) and of whole hypercholesterolemic serum on the esterification of oleic acid and cholesterol was studied in rhesus monkey arterial smooth muscle cells. whole hypercholesterolemic serum and isolated ldl stimulated cholesterol esterification as much as 10-fold using either cholesterol-1,2-3h or oleate-1-14c as substrate. at the same concentrations of cholesterol, hdl stimulated cholesterol esterification to ... | 1977 | 191212 |
| comparative complement fixation and serum neutralization antibody titers to herpes simplex virus type 1 and herpesvirus simiae in macaca mulatta and humans. | the serological relationship of herpes simplex type 1 virus and herpesvirus simiae was studied. antibody titers to these viruses were determined in 163 macaca mulatta sera and 67 human sera by serum neutralization (sn) and complement fixation (cf) tests. both groups of sera were also tested by cf with envelope and capsid antigens of herpes simplex type 1. by sn, the majority of the monkeys and all of the humans had a higher titer to herpes simplex type 1 than to h. simiae. by cf, with crude anti ... | 1977 | 192762 |
| spontaneous malignant histiocytoma with metastasis in a rhesus monkey [macaca mulatta]. | a malignant histiocytoma was observed on the left arm of a recently imported rhesus monkey. rapid invasion of deep tissues and tumor growth on the face prompted euthanasia. necropsy revealed additional neoplastic foci in the lungs, diaphragm, intercostal muscles, pericardium and liver. microscopically the predominant cell type was histiocytic; some cells had a distinct epithelioid appearance and other were spindle-shaped. | 1977 | 194039 |
| effects of cholesterol feeding on primate serum lipoproteins. ii. low density lipoprotein characterization from rhesus monkeys with a moderate rise in serum cholesterol. | | 1977 | 194586 |
| dengue viruses and mononuclear phagocytes. ii. identity of blood and tissue leukocytes supporting in vitro infection. | studies were made on the identity of human and monkey mononuclear leukocytes permissive to antibody-enhanced dengue 2 virus (d2v) infection. in cultures of peripheral blood leukocytes (pbl) inoculated immediately after separation, it was concluded that only mononuclear phagocytes support dengue infection. this is based upon observations that d2v-permissive cells were resistant to 1,200 rads, were both plastic adherent and nonadherent, were removed when passed through nylon wool columns in 10 per ... | 1977 | 195000 |
| comparison of primary rhesus and cynomolgus monkey kidney cell cultures for viral isolation from clinical specimens. | rhesus monkey kidney and cynomolgus monkey kidney cell cultures were compared for viral isolation by using clinical specimens that yielded 203 viral isolates. cynomolgus and rhesus monkey kidney cells were comparable for the isolation of 22 adenoviruses, 12 coxsackieviruses, and one poliovirus. four of 50 echoviruses and seven of ten herpesviruses were detected only in cynomolgus monkey kidney cells. influenza virus was isolated in 84 instances, of which eight were detected only in rhesus and fo ... | 1977 | 195459 |
| in vitro regulation of cholesterol metabolism by low density lipoproteins in skin fibroblasts from hypo-and hyperresponding squirrel monkeys. | when squirrel monkeys (saimiri sciureus) are fed diets containing cholesterol, some individuals (hyperresponders) become hypercholesterolemic, while others (hyporesponders) are able to maintain nearly normal plasma cholesterol concentrations. skin fibroblasts were grown from three hyperresponder and threehyporesponder squirrel monkeys, previously characterized on the basis of their plasma cholesterol response to two cholesterol-containing diets and the pheno-type of their parents. the rates of c ... | 1977 | 195626 |
| maintenance of viability and comparison of identification methods for influenza and other respiratory viruses of humans. | a comparison of hanks balanced salt solution, veal infusion broth (vib), and charcoal viral transport medium for maintaining viability of type a influenza virus indicated approximately equal survival of virus on all three media at -70 and 4 degrees c, whereas at 25 degrees c virus survived best in vib. vib supplemented with bovine serum albumin was used as transport medium in a community-wide surveillance of febrile respiratory disease for influenza viruses. unfrozen throat swab specimens were p ... | 1977 | 195979 |
| preparation and evaluation of a noninfectious monkey pox virus vaccine. | monkey pox virus was mechanically disrupted by low temperature and high pressure into soluble and insoluble fractions. soluble fractions elicited virus-neutralizing antibodies (1:20 to 1:160) in rabbits, whereas the insoluble (in saline) fractions did not (less than 1:5). no infectious virus was detected after the disruption procedure. rhesus monkeys immunized with the soluble fraction elicited virus-neutralizing (1:1,200), complement-fixing (1:16), and hemagglutinating-inhibiting (1:80 to 1:160 ... | 1977 | 195980 |
| effects of prostaglandins on cultured granulosa cells from rhesus monkeys. | | 1977 | 196077 |
| [detoxification of staphylococcal-enterotoxin b in water (author's transl)]. | staphylococcal enterotoxin b contaminated water has been detoxified with calcium hypochlorite used in the water treatment procedure which is available now in order to get drinking water from surface water in emergency cases. changes in toxin-activity were measured serologically by agar-gel-immuno-precipitation as well as biologically by the "monkey-feeding test" with young macaca mulatta. with an initial concentration of 50 ppm chlorine in tap water resp. 200 ppm in native surface water concentr ... | 1977 | 196459 |
| the self-association of apolipoprotein a-ii from plasma high density lipoproteins of rhesus monkey (macaca mulatta). | | 1977 | 197103 |
| evidence for dopamine-storing interneurons and paraneurons in rhesus monkey sympathetic ganglia. | in order to study and quantify the small, intensely fluorescent (sif) cells and to examine their synaptology, the superior cervical sympathetic ganglia of rhesus monkeys were examined by a sequential glyoxylic acid (ga) monoamine fluorescence and electron microscopic technique. correlated data concerning the sensitivity of the ganglia to dopamine were gathered by measuring the rise in cyclic amp levels following incubation in vitro with exogenous dopamine. cyclic amp levels after incubation for ... | 1977 | 197214 |
| isolation of simian virus 40 from rhesus monkeys (macaca mulatta) with spontaneous progressive multifocal leukoencephalopathy. | isolates of virus from the brain tissue of two naturally occurring cases of progressive multifocal leukoencephalopathy in rhesus monkeys (macaca mulatta) have been characterized. both isolates were demonstrated to be simian virus 40 (sv40) by serological tests and analysis of cleavage fragments of viral deoxyribonucleic acid produced by restriction endonuclease from haemophilus influenzae. sv40 virions and the nonvirion t antigen were demonstrated in the brain lesions of one monkey by the fluore ... | 1977 | 198489 |
| experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis b virus. | the effects of treatments with diethylnitrosamine (dena) and hepatitis b virus (hbv) on macaque monkeys were investigated by virus serology and by light and electron microscopy. the experimental groups comprised 43 newborn or juvenile cynomolgus and rhesus monkeys of both sexes. hbv neither had a carcinogenic effect nor increased the oncogenic effect of dena. however, hbv given to juvenile primates before treatment with dena resulted in subsequent gross and microscopic alterations consistent wit ... | 1977 | 198564 |
| the behaviour of sabin attenuated poliovirus strains in the central nervous system of rhesus monkeys. | | 1977 | 200628 |
| sedimentation behavior of native and reduced apolipoprotein a-ii from human high density lipoproteins. | the solution properties of human serum apolipoprotein a-ii, both in the native and in the reduced forms, were investigated by the technique of sedimentation equilibrium in the analytical ultracentrifuge. for both proteins, the apparent weight average molecular weights determined in neutral buffer systems were found to be dependent on protein concentration and invariant with the rotor speeds used (16,000 to 44,000 rpm) indicating a reversible self-association. these results were also found to be ... | 1978 | 201282 |
| effect of input multiplicity on the establishment of simian virus 40 persistent infections in rhesus monkey kidney cells. | monolayer cultures of llc-mk2 rhesus monkey kidney cells become persistently infected with simian virus 40 after infection at input multiplicities of 100, 10, or 1 plaque-forming unit per cell. after 3 weeks, all cells of the cultures infected at a multiplicity of 1 plaque-forming unit per cell produced the simian virus 40 t antigen. in contrast, 8 to 11 weeks elapsed before all the cells in the cultures infected at a multiplicity of 100 plaque-forming units per cell produced t antigen. defectiv ... | 1977 | 201570 |
| nonhuman primates: laboratory animals of choice for neurophysiologic studies of sleep. | a systematic study was made of several nonhuman primates to learn more about their relative usefulness for studies of sleep. species studied included the guinea baboon (papio papio), kenya or yellow baboon (p cynocephalus), olive baboon (p anubis), sacred baboon (p hamadryas), vervet monkey (cercopithecus aethiops), rhesus monkey (macaca mulatta), bonnet monkey (m radiata), crab-eating monkey (m fascicularis), patas monkey (erythrocebus patas), chimpanzee (pan troglodytes), mongoose lemur (lemur ... | 1977 | 201798 |
| interspecies radioimmunoassay for the major structural proteins of primate type-d retroviruses. | a competition radioimmunoassay has been developed in which type-d retroviruses from three primate species compete. the assay utilizes the major structural protein (36,000 daltons) of the endogenous squirrel monkey retrovirus and antisera directed against the major structural protein (27,000 daltons) of the mason-pfizer monkey virus isolated from rhesus monkeys. purified preparations of both viruses grown in heterologous cells, as well as extracts of heterologous cells infected with squirrel monk ... | 1977 | 202962 |
| histochemical distribution of phosphatases in different regions of the epididymis of the adult rhesus monkey macaca mulatta. | | 1977 | 203524 |
| phytohemagglutinin enhancement of dengue-2 virus replication in nonimmune rhesus monkey peripheral blood leukocytes. | phytohemagglutinin treatment of peripheral blood leukocytes from dengue nonimmune monkeys enhanced dengue-2 virus replication. enhancement was due primarily to an increase in the number of infected cells. destruction of mononuclear phagocytes with silica did not significantly inhibit virus replication in phytohemagglutinin-treated cultures. pokeweed mitogen, concanavalin a, and streptolysin o stimulated increased deoxyribonucleic acid synthesis in monkey leukocytes but did not enhance virus repl ... | 1978 | 203535 |
| cerebrospinal fluid cyclic amp levels in rhesus monkeys: daily fluctuations. | | 1978 | 203813 |
| morphine reduces cerebellar guanosine-3',5'-cyclic monophosphate content and elevates cerebrospinal fluid guanosine-3',5'-cyclic monophosphate content in rhesus monkey. | | 1978 | 203814 |
| measurment of rhesus monkey (macaca mulatta) apolipoprotein b in serum by radioimmunoassay: comparison of immunoreactivities of rhesus and human low density lipoproteins. | a sensitive and specific double antibody radio-immunoassay for the major apolipoprotein (apob) of rhesus (macaca mulatta) serum very low density lipoprotein (vldl) and low density lipoprotein (ldl) is described. the anti-serum was raised to ldl (d 1.030-1.040 g/ml) and the ldl(2) (d 1.020-1.050 g/ml) was labeled with (125)i by the chloramine-t or iodine monochloride method. the assay, which was sensitive to 0.02-0.5 micro g of ldl(2), had an inter-assay coefficient of variation of 4.5%. this ass ... | 1978 | 204718 |
| necrotizing pancreatitis due to simian adenovirus type 31 in a rhesus monkey. | simian adenovirus type 31 was isolated from pancreatic tissue of an 8-year-old male rhesus monkey that died as the result of acute necrotizing pancreatitis. histologically, the pancreas showed wide-spread necrosis, extensive infiltration of polymorphonuclear leukocytes, and nuclear inclusions in pancreatic acinar cells. large numbers of adenovirus particles were demonstrable in the acinar cells by electron microscopy. this is the second case of adenovirus-associated pancreatitis we have found in ... | 1978 | 205187 |
| endocrine and pharmacological factors which influence the onset of labour in rhesus monkeys. | indomethacin administration in late pregnancy prolonged gestation in caged rhesus monkeys and inhibited premature labour and postponed delivery in chronically catheterized monkey fetuses. chronic indomethacin treatment was associated with a reduction in the urinary excretion of a prostaglandin metabolite, a potent inhibitory effect on myometrial cyclic amp phosphodiesterase, and severe oligohydramnios in pre-term and post-term fetuses. experimental anencephaly (functional hypophysectomy) of the ... | 1977 | 205394 |
| effect of cardiac arrest on cerebral circulation. an experimental investigation. | the effect of 2 to 15 min of cardiac arrest on cerebral circulation was investigated in dogs and rhesus monkeys. when circulatory arrest lasted longer than 5 minutes, angiographic changes of the no-reflow phenomenon were observed between 3 and 4 h after resuscitation in dogs but not in monkeys. these findings were (1) marked prolongation of the arterial phase in both intracranial and extracranial arteries; followed by (2) occasional evidence of dilatation of the proximal intracranial arteries wi ... | 1976 | 207089 |
| [use of the monkey pox virus for evaluating the intensity of the immunity against smallpox in experiments on m. rhesus]. | monkeypox virus causing in m, rhesus upon aerogenic infection a disease similar to human varioloid was used to evaluate the intensity of immunity against smallpox in immunized m. rhesus monkeys. postvaccination immunity was solid in all the animals vaccinated intradermally or orally. in 2 out of 14 monkeys immunized orally, however, the immunity was partially overcome. neutralizing antibody titers in these two monkeys were 1:5 and 1:25, respectively. this agreed with the observations made in pak ... | 1978 | 208308 |
| differential effects of isolated lipoproteins from normal and hypercholesterolemic rhesus monkeys on cholesterol esterification and accumulation in arterial smooth muscle cells in culture. | whole serum obtained from hypercholesterolemic rhesus monkeys was found to stimulate cholesterol esterification and cholesteryl ester accumulation in rhesus monkey arterial smooth muscle cells in culture to a significantly greater extent than normocholesterolemic serum. this was true even when the cholesterol concentration of the culture medium was equalized. isolation and characterzation of the low density lipoproteins (ldl) from rhesus monkeys indicated that the ldl from hypercholesterolemic a ... | 1978 | 208631 |
| the refractory state of luteal cells isolated from rhesus monkeys after prolonged exposure to chorionic gonadotropin during early pregnancy. | | 1978 | 208669 |
| loss on serial passage of rhesus monkey kidney cells of proteolytic activity required for sendai virus activation. | primary and secondary cultures of rhesus monkey kidney cells supported multiple-cycle replication of sendai virus, but later passages lost this ability, and this was reflected in decreased plaque formation. multiple-cycle replication also did not occur in llc-mk2 cells, a continuous line of rmk cells. failure of replication in serially passed cells was correlated with a decrease in proteolytic cleavage of a viral surface glycoprotein (fo), and the ability of cells to support multiple-cycle repli ... | 1978 | 208971 |
| responses of nonhuman primates to a polybrominated biphenyl mixture. | in a series of experiments, rhesus monkeys have been given in their diets 0.3, 1.5, and 25 ppm of a commercial polybrominated biphenyl (pbb) (as firemaster ff-1). the seven adult female monkeys receiving 0.3 ppm pbb have been on the treatment regime for 15 months and have consumed over 22 mg of pbb. during the initial 6 months of exposure, they lost weight and 2 of the animals develop sterile abscesses. at 6 months, 4 of the 7 animals had flattened and lengthened serum progesterone peaks. this c ... | 1978 | 209967 |
| opiate receptor binding in rhesus monkey brain: association with limbic structures. | | 1978 | 210898 |
| spontaneous esophageal carcinoma and epithelial cell line of an adult rhesus monkey. | a continuous epithelial cell line, 816a, was established from a lymph node of an adult rhesus monkey with metastatic esophageal carcinoma. these cells are characterized by the presence of desmosomes and a markedly heteroploid karyotype. at a relatively early culture age, electron microscopy showed both budding and extracellular type c virus. antigen reactive with antisera to mason-pfizer monkey virus was observed by complement-fixation. the level of this antigen decreased with increased culture ... | 1978 | 210934 |
| caffeine elicited withdrawal signs in morphine-dependent rhesus monkeys. | in the dose range of 4.0--32.0 mg/kg s.c., caffeine produced most of the signs which are commonly seen after the administration of naloxone (0.05 mg/kg s.c.) to morphine-dependent monkeys. the signs designated as lying on side or abdomen, avoiding contact, vocalizing, crawling or rolling, restlessness or pacing, tremors, retching, vomiting, coughing, vocalizing when abdomen palpated, rigid abdomen and salivation were noted. a randomized and blind experimental design, which included vehicle and p ... | 1978 | 211041 |
| disseminated lymphoma in a rhesus monkey: a case report. | a rhesus monkey was inoculated with rhesus cytomegalovirus. a leukocyte-associated herpes virus, unrelated to cytomegalovirus, was later isolated from the same monkey. four years after the virus inoculation, the monkey developed a disseminated lymphoma. | 1978 | 212640 |
| the effects of prolonged ingestion of dieldrin on the livers of male rhesus monkeys. | | 1978 | 214292 |
| the acth 'family tree' of the rhesus monkey changes with development. | | 1978 | 214709 |
| comparative sensitivity of various cell culture systems for isolation of viruses from wastewater and fecal samples. | in efforts to define the most sensitive cell culture systems for recovery of viruses from wastewaters, 181 samples were inoculated in parallel into tube cultures of various cell types and were plaqued in bottle and petri dish cultures of three types of monkey kidney cells. polioviruses were recovered most frequently in the rd line of human rhabdomyosarcoma cells, group a coxsackieviruses in rd and human fetal diploid kidney (hfdk) cells, group b coxsackieviruses in the bgm line of african green ... | 1978 | 215087 |
| effect of corticotrophin on cortisol secretion in castrated rhesus monkeys. | | 1978 | 215692 |
| effects of local anesthesia on gingival camp levels. | the basal levels of camp in the attached gingiva of rhesus monkeys and the changes in tissue camp levels produced by infiltration anesthesia with lidocaine and lidocaine containing 1:100,000 epinephrine were studied. the basal level of camp in uninjected monkey gingiva ranged from 12 to 20 picomoles of camp per mg of gingival protein. this level was 75 times greater than the camp content of monkey blood plasma. infiltration of the attached gingiva with saline or plain lidocaine for 5 minutes did ... | 1979 | 216792 |
| in vivo regulation of the fetal rhesus monkey adrenal gland. | | 1978 | 217644 |
| viral antibodies in rhesus monkey sera collected in india. | | 1978 | 217821 |
| development and experimental evaluation of a contrast medium for computed tomographic examination of the liver and spleen. | a lipoid based contrast material containing 53% of ethiodized oil in emulsion form was developed for computed tomography (ct) of the liver and spleen and tested in rabbits and monkeys. an intravenous dose of 0.2 ml/kg selectively opacified the liver and spleen, resulting in an average increase of 23 emi units (500 scales) in the attenuation of the liver and a higher increase in the attenuation of the spleen. when injected into rhesus monkeys with carcinogen induced hepatomas there was a signific ... | 1979 | 217896 |
| protease activation of sendai virus infectivity; studies in non-permissive and permissive cells. | non-infectious virus particles are produced by bsc-1 cells after infection with sendai virus. trypsin treatment of these particles activates their infectivity. the studies reported here show that such non-infectious virus particles adsorb normally to cells but cannot initiate infection even after very long adsorption periods. secondary rhesus monkey kidney cells support the growth of sendai virus but cannot activate the infectivity of virus grown in bsc-1 cells. the significance of these results ... | 1978 | 217954 |
| viral type a and type b hepatitis: morphology, biology, immunology and epidemiology--a review. | viral hepatitis is one of the most serious infectious diseases in the united states and is of great concern to the public health agencies, hospitals and research laboratories. progress in our knowledge of this disease has been based on cooperation between specialists in many diverse scientific disciplines employing sophisticated scientific instruments and technics. close cooperation between clinical pathologists and clinicians is of great importance in diagnosis. biologic, immunologic, epidemiol ... | 1976 | 218439 |
| virus particles in the basal plate of rhesus monkey and baboon placenta. | c-type virus particles and particles, approximately 35 nm in diameter, were present in the region of the basal plate from the placenta of a rhesus monkey and two baboons. both particles appeared to bud from the plasma membrane of the cytotrophoblast: large, pleomorphic cells with cytoplasmic extensions, indented nuclei, well-developed endoplasmic reticulum, and glycogen deposits. extracellular particles were enmeshed within a fibrous matrix. particles were also observed in the junctional zone, b ... | 1979 | 218734 |
| canine kidney cell line for isolation of respiratory viruses. | by means of a continuous canine kidney cell line (mdck), influenza viruses were rapidly isolated from specimens collected from patients with respiratory disease. the cell line proved more sensitive than either eggs or rhesus monkey cells for currently circulating influenza a and b strains. influenza viruses caused a distinct cytopathology within 5 days of inoculation if trypsin-ethylenediamine-tetraacetic acid was incorporated into the medium. sufficient hemagglutinin was produced on the initial ... | 1979 | 219021 |
| pyruvate carboxylase deficiency and lactic acidosis in a retarded child without leigh's disease. | a child with lactic acidosis, severe mental and developmental retardation, and proximal renal tubular acidosis is presented. biopsy and autopsy studies show severe hepatic, renal cortical, and cerebral deficiencies in pyruvate carboxylase (ec 6.4.1.1) activity. the patient had 1.81 +/- 0.20 units/g fresh weight at biopsy and 0.75 +/- 0.07 units/g fresh weight hepatic pyruvate carboxylase activity at autopsy compared with 10.9, 11.3, and 9.5 units/g fresh weight in two autopsy and one biopsy cont ... | 1979 | 219411 |
| isolation and biological characterization of an adenovirus of rhesus macaques. | the etiology of a disease in rhesus monkeys the main clinical manifestation of which was acute conjunctivitis of an epizootic character has been studied. the cytopathogenic agent well propagating in primarily trypsinized kidney cells of monkeys has been isolated when investigating the affected eye mucosa. it was not pathogenic for laboratory animals. the mean diameter of the virions is 75 nm, the buoyant density in cscl is 1.34 g/cm3, the viral dna density is 1.706 g/cm3. the biological properti ... | 1978 | 219642 |
| the effect of coffee consumption on plasma lipids, lipoproteins, and the development of aortic atherosclerosis in rhesus monkeys fed an atherogenic diet. | rhesus monkeys (seven females and six males) were fed ad libitum a diet comparable to that consumed by humans, containing 25% by weight fat (40% of calories) and 0.15% cholesterol (0.3 mg/kcal) for 12 months (phase 1). from the 13th month all monkeys were continued on the diet while four females and three males were given 50% coffee as their fluid intake and the remainder were water controls (phase 2). major changes in total plasma lipids and lipoprotein profiles occurred within 3 months and gen ... | 1979 | 219678 |
| effect of acute administration of dichlorodiphenyl trichloroethane on certain enzymes of rhesus monkey. | | 1978 | 220189 |
| study of the atherogenic dyslipoproteinemia induced by dietary cholesterol in rhesus monekys (macaca mulatta). | hypercholesterolemia was induced in adult male rhesus monkeys with a high-fat diet containing an elevated cholesterol level (0.5%). plasma lipoproteins were chromatographically separated into four size populations (regions) that were subdivided by density until fractions with single electrophoretic mobilities were obtained. the region iii lipoproteins (ldl) contained 80% of plasma cholesterol and were present in the highest concentration of all fractions. their molecular weight was increased ove ... | 1979 | 220353 |
| regulation of cyclic nucleotide phosphodiesterase activity in myometrium from pregnant and spayed rhesus monkeys. | the activities of myometrial cyclic nucleotide phosphodiesterases (pdes) and the sensitivity of these enzymes to the effector molecules, cgmp and camp, were determined in the 100,000 g supernatant of homogenates from pregnant and spayed rhesus monkeys. the specific activities (per mg nitrogen) of the myometrial cyclic nucleotide pdes in the supernatant from spayed monkeys were higher than those from pregnant monkeys at all substrate levels studied. however, when calculated on the basis of the dn ... | 1979 | 220417 |
| isolation of a cytomegalovirus from salivary glands of white-lipped marmosets (saguinus fuscicollis). | minced salivary glands from seven white-lipped marmosets (saguinus fuscicollis and saguinus nigricollis) and one cotton-topped marmoset (saguinus oedipus) were cocultivated with marmoset cell cultures. a viral agent, designated ssg, was isolated from two saguinus fuscicollis. slowly progressing foci of rounded, vacuolated, refractile cells were first observed at 40-43 days incubation. electron microscopy revealed intranuclear herpesvirus nucleocapsids and intracytoplasmic and extracellular envel ... | 1979 | 220464 |
| in utero regulation of rhesus monkey fetal adrenals: effects of dexamethasone, adrenocorticotropin, thyrotropin-releasing hormone, prolactin, human chorionic gonadotropin, and alpha-melanocyte-stimulating hormone on fetal and maternal plasma steroids. | | 1979 | 221193 |
| in vitro lymphocyte transformation by epstein-barr virus (ebv)-like viruses isolated from old-world non-human primates. | ebv-like viruses and lymphoid cell lines have been isolated from baboons and an orangutan. the cell lines have properties of b- or undifferentiated lymphocytes and have antigens and dna related to those of ebv. the baboon virus has a broad in vitro transformation host range among lymphocytes of old-world simian species whereas the orangutan isolate has a narrower host range. baboon and orangutan viruses as well as ebv have shown transforming activity for gibbon lymphocytes. baboon virus is infec ... | 1978 | 221359 |
| rhesus monkey (macaca mulatta) allotypes. identification of three low density lipoprotein allotypes controlled by independent genes. | three rhesus monkey allotypes are described, which are located on distinct low density lipoprotein molecules. these three markers have been detected using double immunodiffusion in agar. they are inherited in a simple mendelian manner and controlled by three independent genes. | 1979 | 221424 |
| lymphocyte activation by the tumor-promoting agent 12-o-tetradecanoylphorbol-13-acetate (tpa). | tpa, a highly active tumor-promoting agent, is an effective mitogen for primate peripheral blood lymphocytes. optimal stimulation of human lymphocytes was obtained 4 days after the addition of tpa at a concentration of 7.5 ng/ml. lymphocyte fractionation experiments demonstrated that both t and b cells incorporated 3h-thymidine significantly in response to tpa. lymphocyte blastogenesis was not due to the reactivation of latent herpesviruses by the tumor promoter, since similar responses to tpa w ... | 1979 | 221578 |
| accumulation and loss of cholesterol esters in monkey arterial smooth muscle cells exposed to normal and hyperlipemic serum lipoproteins. | the effects of high low and very low density lipoprotein fractions from normal or hyperlipemic rhesus monkey serum on the accumulation or removal of cholesterol esters from rhesus monkey smooth muscle cells in tissue culture were determined. serum or serum lipoproteins were labeled with [14c] free cholesterol and adjusted to the same free cholesterol level in the incubation medium. of the two normal lipoproteins examined, the ldl fraction caused more esterification than the hdl. cells incubated ... | 1979 | 222304 |
| disparate effects of prostaglandins on basal and gonadotropin-stimulated progesterone production by luteal cells isolated from rhesus monkeys during the menstrual cycle and pregnancy. | | 1979 | 222373 |
| comparison of cynomolgus and rhesus monkey kidney cells for recovery of viruses from clinical specimens. | in a study of virus recovery from clinical specimens, cynomolgus monkey kidney cells demonstrated sensitivity equivalent or slightly superior to rhesus kidney cells for siolation of myxo- and paramyxoviruses, adenoviruses, and enteroviruses. | 1979 | 222808 |
| the emergence of simian virus 40 variants in a persistent infection of rhesus monkey kidney cells and their interaction with standard simian virus 40. | | 1979 | 223294 |
| atherogenic diets and neutral-lipid organization in plasma low density lipoproteins. | the plasma low density lipoproteins (ldl) of rhesus monkeys fed 3 atherogenic diets exhibited thermal transitions at temperatures much higher (37--43 degrees c) than those observed in control animals or in normal humans (20--33 degrees c). the same differences were noted in the neutral lipids (cholesteryl esters and triglycerides) which were isolated from the respective lipoproteins. in particular, the difference in thermal properties between the normal and abnormal ldls was attributable to subt ... | 1979 | 223602 |
| isolation and characterization of the three major low density lipoproteins from normolipidemic rhesus monkeys (macaca mulatta). | | 1979 | 224061 |
| experimental interfascicular nerve grafting. | twenty-nine adult rhesus monkeys underwent complete laceration of both tibial nerves at mid-thigh level and repair by different methods to study the relative efficacy of autogenous interfascicular nerve grafts. sixteen animals in group i had an interfascicular graft repair using short sural nerve autografts on one limb and fascicular repair without grafts on the other limb. thirteen animals in group ii, after having a 1-cm segment of tibial nerve resected, had an interfascicular graft repair wit ... | 1979 | 224152 |
| experimental adenovirus sv-20 pneumonia in fetal rhesus monkeys. pathologic and virologic studies. | | 1979 | 224262 |
| small plaque variants of simian virus 40 from a persistent infection of rhesus monkey kidney cells. | | 1979 | 224576 |
| regulation of primate testicular luteinizing hormone receptors and steroidogenesis. | the testicular luteinizing hormone (lh) receptors of the rhesus monkey and human have many features in common, including high equilibrium association constant, marked species specificity, and relatively low binding capacity. we have, therefore, used rhesus monkeys as models for human lh-receptor regulation in vivo during gonadotropin treatment. in four adult male monkeys, treated with 10,000 iu human chorionic gonadotropin (hcg), serum and testicular steroidogenic responses were monitored at 24- ... | 1979 | 225351 |
| immune response of monkeys (macaca mulatta) to amebic antigens. | | 1979 | 225462 |
| physostigmine and recent memory: effects in young and aged nonhuman primates. | the effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. all aged monkeys had previously shown impaired memory. the performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. although the aged subjects also improved at the same general doses, their overall response as a group was much more variable ... | 1979 | 227061 |
| effect of chronic cocaine on behavior and cyclic amp in cerebrospinal fluid of rhesus monkeys. | | 1979 | 227642 |
| comparison of different tissue cultures for isolation and quantitation of influenza and parainfluenza viruses. | rhesus and cynomolgus monkey kidney tissue cultures and two continuous lines, madin-darby canine kidney (mdck) and llc-mk2, were compared in titrations and isolations of influenza and parainfluenza viruses. tube cultures were inoculated with laboratory virus strains or stored patient specimens and observed for hemadsorption. trypsin was added to the medium of the continuous lines to increase sensitivity. all four tissue cultures gave similar titers of influenza a/ussr (h1n1), a/texas (h3n2), and ... | 1979 | 227920 |
| estimation of gestational and skeletal age in macaca mulatta. | results of qualitative and quantitative studies of prenatal skeletal development in macaca mulatta are presented. longitudinal radiographic observations were carried out on 20 monkeys of known gestational age, beginning on 120 days of gestation until the neonatal stage of skeletal development. these studies were based on multiple uterotomies on each pregnant female. the technique described provides accurate data on prenatal bone ossification, and permits an accurate estimation of fetal age in pr ... | 1979 | 228041 |
| chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism. | hyperinsulinemia was produced in fetal rhesus monkeys for 21 days in the last third of gestation by subcutaneous pork insulin injected at 19 u a day. plasma insulin concentrations in treated fetuses (n = 4) were 3525 microu/ml. there was no difference in paired pre- and post-treatment fetal plasma glucose concentration. activity of the hepatic enzymes that promote glucose utilization (glucokinase and hexokinase) and glycolysis (phosphofructokinase, pyruvate kinase, and pyruvate dehydrogenase) wa ... | 1979 | 229050 |
| virus detection in monkeys with diarrhea: the association of adenoviruses with diarrhea and the possible role of rotaviruses. | to explore the role of viruses in the etiology of diarrhea in colony-reared monkeys, direct electron microscopy, the fluorescent virus precipitin test and cell culture inoculation were used to examine the stools of monkeys with and without diarrhea. the animals were predominantly rhesus with a few macaques of other species, and included infants, juveniles and adults. adenoviruses were isolated from a higher proportion of specimens from rhesus monkeys with diarrhea (73% of specimens from infants ... | 1979 | 229340 |
| [zinc activated tartrate resistent phosphatases in the brains of different animal species and their characterization]. | a zinc activated tartrate resistent phosphatase (zntp) of the brain of different animal species was separated by electrofocusing in polyacrylamide gels. it is demonstrable selectively in the presence of 20 mm zinc acetate and 10 mm d,l-sodium tartrate or of 100 mm zinc acetate only. the zntp hydrolyzes 1-naphthyl phosphate and 4-nitrophenyl phosphate, respectively. high activity of zntp is evident in the brains of rats and rabbits. the activity is moderate or absent in the brains of mice, syrian ... | 1979 | 230670 |
| rotavirus antibody assays on monkey sera: a comparison of enzyme immunoassay with neutralization and complement-fixation tests. | an enzyme immunoassay (eia) for the detection of rotaviral antibodies was developed, using a purified, cell culture-grown sa 11 viral antigen and alkaline phosphatase as an enzyme label. this technique was evaluated by comparative testing with tube neutralization and complement-fixation assays on a collection of simian sera. there was close correlation between positive and negative results obtained by eia and by neutralization. the eia was as easy to perform as complement fixation testing, but s ... | 1979 | 230760 |
| isolation and characterization of a new simian foamy virus serotype from lymphocytes of a papio cynocephalus baboon. | a new type of syncytium-forming (foamy) virus was isolated from peripheral lymphocytes of a papio cynocephalus baboon after cocultivation with a rhesus monkey cell line. the isolate was characterized by cytopathogenic effect, host range, electron microscopy, reverse transcriptase activity and physical and chemical properties. seroneutralization tests indicate that the new isolate is antigenically distinct from the other nine known simian foamy virus serotypes. | 1979 | 231658 |
| nor-mdp, saponin, corynebacteria, and pertussis organisms as immunological adjuvants in experimental malaria vaccination of macaques. | vaccination of primates against malaria using antigen derived from erythrocytic parasite stages has been most successful where freund's complete adjuvant has been employed. since this adjuvant is clinically unacceptable its replacement is a matter of urgency.in the present work a muramyldipeptide derivative (nor-mdp) given in mineral oil has proved to be partially effective as an adjuvant for merozoite vaccination of macaca mulatta against plasmodium knowlesi, and saponin has proved to be effect ... | 1979 | 232428 |
| classically conditioned heart rate responses in macaca mulatta after beta-adrenergic, vagal and ganglionic blockade. | heart rates of 5 rhesus monkeys (macaca mulatta) were monitored during classical conditioning trials consisting of a visual conditioned stimulus followed after 10 sec by an electric shock to the tail. heart rates typically increased at the onset of the visual stimulus, and returned to baseline before shock delivery. autonomic blocking agents were subsequently administered; their effects on resting heart rates, and on acceleratory and deceleratory phases of the biphasic conditioned heart rate res ... | 1979 | 233311 |
| pathology of modified graft-versus-host disease in bone marrow allografted monkeys treated with antilymphocyte serum. | lethally irradiated rhesus monkeys were used for bone marrow allografting and autografting. monkeys receiving allogeneic bone marrow developed acute graft-versus-host reaction (gvhr) and had a mean survival time of 9.1 days as compared to autografted monkeys which survived above 500 days. treatment with antilymphocyte sera (als) before allografting modified the gvhr and extended the survival time to an average of 43 days. histologically, such animals showed evidence of "chronic" gvhr and septice ... | 1975 | 234261 |
| hyperreactive arterial endothelial cells in atherogenesis and cyclic amp phosphodiesterase inhibitor in prevention and treatment of atherosclerotic disorders. | the hyperreactive arterial endothelial cells have been introduced in this paper. they are characterized by their ability to transport particles too large for the small holes of the internal elastic lamina locating underneath the endothelial cells, such as carbon particles with the similar size of ldl, floating beta-lipoprotein, lp(a) and especially of vldl, into the subendothelial space from the blood stream by their abnormally strong contracting and phagocytosis-like activity. large particles s ... | 1975 | 234547 |
| oxisuran metabolism in the monkey. | oxisuran metabolism was studied in the rhesus monkey in order to assess the suitability of this species as an immunological model for man. the biotransformation pathways observed in the monkey are the same as those seen in rats and dogs. these pathways include the oxidation of oxisuran to a sulfone not found in human plasma or urine. nevertheless, the monkey may merit immunological evaluation because the half-lives of biotransformation and elimination, although shorter than those exhibited by ma ... | 1975 | 234829 |
| phagocytosis of francisella tularensis by rhesus monkey peripheral leukocytes. | phagocytosis of francisella tularensis by rhesus monkey peripheral neutrophils (pmn, was assessed by autoradiography, electron microscopy, and biochemical techniques. pmn, in contrast to mononuclear phagocytes, were unable to phagocytize f. tularensis in vitro in the absence of immune serum. it is postulated that in the nonimmune host the innate inability of pmn to phagocytize f. tularensis deletes one of the possible mechanisms of host defense to bacterial infection and thus permits the early d ... | 1975 | 234911 |
| central nervous system findings in the newborn monkey following severe in utero partial asphyxia. | seizures, brain swelling, and cortical necrosis have been observed in the newborn rhesus monkey following a 2 to 4-hour period of intrauterine partial asphyxia produced by halothane-induced maternal hypotension. these clinical and neuropathologic findings are similar to those seen in human newborn infants who have experienced an episode of intrauterine asphyxia from such a cause as premature placental separation. the present study strongly indicates that fetal partial asphyxia, from any cause, i ... | 1975 | 235749 |