| results of long-term preservation of mycobacteria by means of freeze-drying. | | 1976 | 819214 |
| reevaluation of inguinal lymph node injection for production of adjuvant arthritis in the rat. | an experiment was designed to compare the efficiency of lymph node injection for the induction of adjuvant arthritis (aa) with that of conventional footpad injection in the rat. quantitative studies revealed that the minimal dose required for induction of aa by the lymph node route is one fifth of that by the footpad route. thus, the lymph node route was found to be more efficient than the footpad method in terms of higher incidence and earlier onset of aa. ppd in freund's incomplete adjuvant wa ... | 1976 | 819381 |
| effect of degradation of the arabinogalactan portionof a water-soluble component from m. tuberculosis wax d on polyarthritis induction in the rat. | in order to explore a possible role of the arabinogalactin (ag) portion of the water-soluble arthritogenic component (wac) from m. tuberculosis wax d for induction of adjuvant arthritis (aa) in the rat, this component was digested with an ag-degrading enzyme. the enzyme-digested wac was able to produce aa. the severity of aa was almost comparable to that of the nondigested wac. this finding suggests that the ag portion of the wac does not seem to be essential for aa induction and indirectly poin ... | 1976 | 819382 |
| three simple tests as an adjunct to the niacin test for the small mycobacteriology laboratory. | with the change in the management of tuberculosis, many bacteriology laboratories should be prepared to examine sputum for the presence of acid-fast bacilli. the niacin test is the most reliable test that can be performed in any mycobacteriology laboratory to differentiate mycobacterium tuberculosis from the other acid-fast bacilli, but it is not perfect. other tests can be used to supplement it are cord formation, growth at 24 c, and the catalase test at 68 c. incompletely identified strains sh ... | 1976 | 819396 |
| a mycobacteriology proficiency testing program using simulated sputum specimens. | the new york state department of health proficiency testing program in mycobacteriology determines the ability of a laboratory to isolate the acid-fast bacillus present in a simulated specimen and to identify the strain. until 1964 the specimens were autoclaved normal sputa seeded with mycobacteria. when mandatory testing was introduced by law in 1964, more specimens were needed. these have been prepared in simulated sputum bases, first skimmed milk, then granulated hog gastric mucin. the bases ... | 1976 | 819397 |
| [mixed crystal tuberculoprotein from h37rv strain of mycobacterium tuberculosis (author's transl)]. | | 1976 | 819703 |
| [immunity against mycobacterium, with special reference to the experiments using bcg cell wall]. | | 1976 | 819704 |
| [drug resistance of mycobacterium (including clinical studies)]. | | 1976 | 819705 |
| [biochemical genetics of drug resistance of mycobacterium]. | | 1976 | 819706 |
| [response to ppd in tuberculosis patients infected with m tuberculosis and m bovis]. | | 1976 | 819758 |
| [the effects of haptenic presentation on b and t cell responses]. | in this study the effect of haptenic presentation on the nature of immune response was investigated. haptens (such as p-aminobenzoic acid, p-amino sulphanilic acid and p-aminoarsanilic acid) were coupled to an amino acid (tyrosine) alone, a protein (bovine serum albumine) a bacteria (m. tuberculosis) and injected to guinea pigs. hapten specific humoral immune response was determined by either quantitative precipitin test or passive hemolysin test. macrophage migration inhibition and skin tests w ... | 1976 | 819762 |
| investigation of the inhibitory activity of some mycobacterial strains on growth of the intratracheally transplanted deals' sarcoma in guinea pigs. | in this paper the authors describe and analyse results that they obtained by infection of the guinea pig organism carried out by subcutaneous or intratracheal application with five mycobacterial strains, namely myco bovis bcg-praha, myco the h37ra, myco kansasii, myco fortuitum and myco smegmatis. at predetermined time intervals following subcutaneously or intratracheally performed infection (on 7th, 16th, 28th and 56th day after infection) transplantation of a deals' guinea pig sarcoma cell sus ... | 1976 | 819851 |
| pelvic tuberculosis. | pelvic tuberculosis (tbc) was diagnosed in 20 patients studied during the years 1971 to 1975. fourteen patients were born outside the united states. the most frequent presenting complaints were infertility (14 patients), pelvic pain (6), and amenorrhea (4). only 5 patients gave a history of previous treatment for tbc. results of pelvic examination were normal in 11 patients; results of chest x-rays were normal in 15. sixteen patients had endometrial biopsies, 10 of which showed granulomatous end ... | 1976 | 819884 |
| [mechanism of the effect of acridine compounds and furadonine on the delay in the development of drug resistance of mycobacterium tuberculosis]. | | 1975 | 819924 |
| [lauryl sulfate method in culturing sputum for primary isolation of mycobacteria]. | | 1975 | 819948 |
| [fluorescence microscopy]. | | 1975 | 819949 |
| [primary resistance in 126 cases of pulmonary tuberculosis]. | | 1976 | 819999 |
| [bovine tuberculosis, isolation of mycobacteria from cattle]. | | 1976 | 820000 |
| [case finding by means of microscopy of sputum]. | | 1976 | 820001 |
| pulmonary tuberculosis in scotland: a national sample survey and follow-up (1968-70). 1. the characteristics of the cases notified in 1968. | a survey has been undertaken of a 50 per cent random sample of 865 patients notified as having pulmonary tuberculosis in 1968 in scotland. the estimated notification rate for the total population was 33.3 per 100,000. the highest rate for males was 89.8 for those aged 55 or more and for females 29.5 for those aged 25 to 54. the rates for bacteriologically confirmed cases were 51.6 and 16.0, respectively, for these two groups. an independent radiological assessor reported the characteristic appea ... | 1975 | 820025 |
| [use of nekal bx for pretreatment of clinical material before culture to diagnose tuberculosis (author's transl)]. | recently, also detergents have been proposed for use in the pretreatment of clinical material for cultural demonstration of mycobacterium tuberculosis. one of such substances is the anionic detergent. neckal bx (diisobutyl naphthaline sulphonate) which in combination with 0.5% sodium hydroxide, is capable of homogenization and decontamination of the material within 16-18 h of action. at the same time, the mycobacteria are accumulated in the sediment by precipitation in the presence of barium, ca ... | 1976 | 820130 |
| tuberculin antigens: the need for purification. | | 1976 | 820226 |
| results of typing of "m. tuberculosis" with seven known and two adapted phages. | | 1975 | 820283 |
| phage typing of strains of "m. tuberculosis" in the netherlands. | | 1975 | 820284 |
| phage typing report of 125 strains of "mycobacterium tuberculosis". | | 1975 | 820285 |
| phage typing of japanese strains of "m. tuberculosis". | | 1975 | 820286 |
| phage typification of 100 strains of "mycobacterium tuberculosis" isolated in czechoslovakia. | | 1975 | 820287 |
| phage susceptibility patterns of "m. tuberculosis" strains freshly isolated from virginia patients. | | 1975 | 820288 |
| sulfatides of mycobacterium tuberculosis: the structure of the principal sulfatide (sl-i). | the gross structural features of five families of multiacylated trehalose 2-sulfates elaborated by mycobacterium tuberculosis strain h37rv are described. the principal sufatide sl-i is a 2,3,6,6'-tetraacyl-alpha,alphs'-d-trehalose 2'-sulfate, whose component carboxylate substituents (and homolgy) were previously established. in the present study the specific locations of the acyl substituents were assigned. the desulfated glycolipid (sl-i-cf) was methanolyzed on a column of diethylaminoethylcell ... | 1976 | 820371 |
| contact sensitivity in rabbits sensitized with dinitrophenylated mycobacterium tuberculosis. | | 1976 | 820433 |
| effect of treatment with the methanol extraction residue fraction of killed tubercle bacilli (mer) on the development of spontaneous pulmonary metastases from syngeneic implants of tumor 3ll in c57b1 mice. | treatment of c57b1 mice with the methanol extraction residue fraction of killed tubercle bacilli (mer) shortly before or after surgical removal of a syngeneic implant of lung carcinoma 3ll reduced the incidence of spontaneous, fatally progressing pulmonary metastases in a large number of instances. under certain conditions, the protective action of mer was pronounced and statistically significant. small quantities of mer (0.2 mg) were optimally effective, when administered i.p. two days before o ... | 1976 | 820672 |
| methanol extraction residue fraction of tubercle bacilli (mer) and other mycobacterial extracts as systemic immunity adjuvants in cancer immunotherapy. | four mycobacterial extracts--two water soluble and two water insoluble--were tested for their immunostimulatory and antitumor activities: mer, the methanol extraction residue fraction of tubercle bacilli (insoluble); hiu i, an insoluble component of the membrane of whole cells of bacillus calmette-guérin (bcg); hiu ii, a soluble component of bcg; and lederer's wsa, a soluble extract of mycobacterium smegmatis. in a hemolytic plaque-forming cell assay, mer, hiu ii and wsa showed immunostimulator ... | 1976 | 820673 |
| regulation of antibody response in different immunoglobulin classes. i. selective suppression of anti-dnp ige antibody response by preadministration of dnp-coupled mycobacterium. | selective suppression of ige antibody response was demonstrated. preadministration of dnp-coupled mycobacterium (dnp-tbc) inhibited the formation of anti-dnp ige antibody induced by dnp-oa without any suppressive effect on anti-dnp igg antibody response. secondary anti-dnp ige antibody response by dnp-oa was also significantly depressed by the preadministration of dnp-tbc. anti-oa ige antibody response induced by dnp-oa was also depressed by dnp-tbc, whereas anti-oa ige antibody response induced ... | 1976 | 820800 |
| in vitro studies on the mechanism of acquired resistance to tuberculous infection. i. the relationship between lymphocytes and macrophages in cellular immunity to tuberculous infection. | the relationship between lymphocytes and macrophages in cellular immunity against tuberculous infection was studied by means of an in vitro cell culture system without addition of streptomycin. the peritoneal macrophages were obtained from normal mice or mice immunized with heat-killed tubercle bacilli in paraffin oil, boosted with live bcg and infected with h37rv cells in vitro. the infected monolayers of macrophages were cultivated for 48 hr with immune lymphoid cells obtained from immunized m ... | 1976 | 820895 |
| [immunological properties of attenuated tuberculosis strain "bk-kharkov". i. the comparative characteristics of the structural lipids and their relationship to the immunogenic properties of the "bk-kharkov" and bcg strains]. | | 1976 | 820948 |
| [rifampicin combined with ethambutol and other antitubercular drugs in the treatment of patients with pulmonary tuberculosis. early results. i. bacteriological evaluation]. | | 1976 | 821043 |
| prevention of phagosome-lysosome fusion in cultured macrophages by sulfatides of mycobacterium tuberculosis. | intracellular parasites (e.g., mycobacterium tuberculosis, toxoplasma gondii, and some chlamydiae) may promote their survival within the host by acting from within phagosomes to prevent phagolysosome formation, thus avoiding exposure to the lysosomal hydrolases. the present studies demonstrate that when sulfatides of m. tuberculosis (anionic trehalose glycolipids largely responsible for the neutral red reactivity of virulent strains) are administered to cultured mouse peritoneal macrophages, the ... | 1976 | 821057 |
| serological diagnosis of tuberculosis: a report of 12 months' clinical experience. | this study reports the use of an agglutination test as a routine diagnostic aid for tuberculosis. we have found this to be both useful and reliable in clinical practice. the overall reliability was greater than 90%, 13 false results being obtained in the 222 patients tested. false negatives (4) were less common than false positives (9). the major advantage of the test is its speed, serological diagnosis being available overnight as compared with an average of one month for diagnosis by culture. | 1976 | 821170 |
| bacteriophage typing of mycobacterium tuberculosis strains isolated in south east england. | the species mycobacterium tuberculosis may be subdivided by its susceptibility to lysis by bacteriophages. in this study 300 strains have been typed with six phages to determine the prevalence of various phage types in south east england. the distribution of the phage types is considered in relation to the patients' racial origins and the clinical presentation of disease, whether pulmonary or extrapulmonary. the technical aspects of phage typing are described and modifications of existing techni ... | 1976 | 821195 |
| the detection of antibodies to mycobacterium tuberculosis by microplate enzyme-linked immunosorbent assay (elisa). | the detection of antibodies to mycobacterium tuberculosis by enzyme-linked immunosorbent assay has proved to be a potentially useful technique for the serodiagnosis of tuberculosis. the technique is capable of full automation. the use of a purified antigen should further improve the sensitivity of the method. | 1976 | 821196 |
| tuberculosis of the larynx masquerading as carcinoma. | a patient with laryngeal and pulmonary tuberculosis is described. the similarity between the clinical presentation and gross appearance of laryngeal carcinoma and tuberculosis in this patient and others reported in the literature is emphasized. laryngeal biopsy is necessary to establish the correct diagnosis, but this must be done only after the proper precautions are taken to reduce the risk of infection to the physician performing the biopsy. examination of the chest x-ray and acid-fast stain ... | 1976 | 821379 |
| comparison of mycobacterium africanum, m. tuberculosis and m. bovis by their utilization of carbon and nitrogen sources. | | 1975 | 821405 |
| structure-activity correlations in a homologous series of 2-substituted isonicotinic acid hydrazides. | | 1976 | 821772 |
| the application of hückel molecular orbital calculations to study of antituberculotic activity of thioamides. | | 1976 | 821773 |
| isociatrate lyase in mycobacteria. | | 1976 | 821851 |
| a new practical classification of the mycobacteria. | a new classification is presented for mycobacteria cultured from clinical specimens. five categories were defined on temperature requirement, and these were subdivided into 14 groups by pigmentation, oxygen preference and tween hydrolysis. support for some of the groups and for the recognition of certain important species within others was provided by drug-sensitivity tests. less than 1-0% of the opportunist mycobacteria met in britain eluded classification by these means. | 1976 | 822166 |
| letter: transmission of tuberculosis. | | 1976 | 822179 |
| [secondary drug resistance of mycobacterium tuberculosis in coniotuberculosis and pulmonary tuberculosis]. | | 1976 | 822417 |
| [characteristics of the action of ethambutol in experimental tuberculosis]. | | 1976 | 822418 |
| [the relationship between structure and tuberculostatic effect in the benzylamine group]. | | 1976 | 822433 |
| [koch's bacillus in the blood and muscle of tuberculous cattle]. | | 1976 | 822481 |
| a comparative study of daily followed by twice- or once-weekly regimens of ethambutol and rifampicin in the retreatment of patients with pulmonary tuberculosis: second report. | three hundred and twenty-nine patients with isoniazid-resistant cultures, 66% with radiographically far advanced disease and 86% with cavities, have been treated with rifampicin and ethambutol and followed-up for 2 years after the end of treatment. the drugs were given daily for 12 weeks (600 mg rifampicin and 25 mg/kg ethambutol), thereafter once- or twice-weekly (600 or 1200 mg rifampicin and 50 mg/kg ethambutol) for a total of 12, 18 or 24 months (in the 600 mg group for 12 months only). with ... | 1976 | 822547 |
| study of adverse reactions to a once-weekly regimen of streptomycin plus a slow-release preparation of isoniazid in high dosage for six months. | a once-weekly regimen of streptomycin (1 g) plus a slow-release preparation of isoniazid (matrix isoniazid) in high dosage, namely 50 mg/kg body-weight for rapid inactivators of isoniazid and 35 mg/kg for slow inactivators, was prescribed for 6 months to 64 tuberculous patients (27 rapid, 37 slow). the regimen was tolerated by most the of the patients. however, 4 rapid and 3 slow inactivators had a modification of the regimen, mainly for giddiness. there were no cases of peripheral neuropathy. n ... | 1976 | 822548 |
| the treatment of tuberculosis of the female genital tract with streptomycin, pas and isoniazid. | an analysis has been made of the results of treatment of 206 patients with tuberculosis of the female genital tract, using a combination of streptomycin, pas and isoniazid for 18 months or two years. there was no follow-up in 21 cases. one hundred and sixty-six patients (90 per cent of those traced) were judged to be cured after an average period of six years from the end of treatment. in 19 cases (10 per cent) drug treatment failed and operation was employed. the results of surgical treatment u ... | 1976 | 822549 |
| [current information on the epidemiology and clinical aspects of tuberculosis]. | | 1976 | 822601 |
| [disinfecting action of peracetic acid against mycobacterium tuberculosis]. | | 1976 | 822606 |
| modifications in the establishment of allergic encephalomyelitis (eae) in rats; an imporved assay for immunosuppressant drugs. | eae induced in lewis rats by guinea-pig spinal cord and such lipid adjuvants as hexadecane or squalene (without the mycobacterial component) is more sensitive to lower doses of cyclophosphamide and some select immunosuppressive agents than the conventional eae induced using freund's complete adjuvant. in addition, these animals do not suffer from adjuvant arthritis which may be induced if the bacterial component is present. these modifications in the conventional assay have enhanced its ability ... | 1976 | 822699 |
| letter: reliability of the acid-fast smear procedure. | | 1976 | 822710 |
| reactivation of genito-urinary tuberculosis: a retrospective review of 838 cases. | relapse occurred in 53 cases out of 838 consecutive cases of genito-urinary tuberculosis, followed for periods of 11 months to 27 years. initial and recurrent disease is classified, and the treatment given is described. length of inactivity is estimated, and correlated with the type of therapy given. sensitivity of the organisms to chemotherapy is stated. conclusions suggest that a life-long follow-up, at yearly intervals, of patients with genito-urinary tuberculosis is justified, as recurrences ... | 1975 | 823023 |
| [hygienic evaluation of the operating effectiveness of purification installations for the sewage from tuberculosis institutions]. | | 1976 | 823075 |
| partial characterization of a factor extracted from sensitized lymphocytes that inhibits the growth of mycobacterium tuberculosis within macrophages in vitro. | spleen lymphocytes of bcg-immunized mice contain a soluble factor that inhibits in vitro the growth of the h37rv strain of mycobacterium tuberculosis within normal peritoneal macrophages. the water-soluble extracts of sensitized lymphocytes, disrupted by freezing and thawing, although less active than the corresponding viable cells retained a significant growth-inhibiting activity. dialysis against distilled water, lyophilization, exposure to ribonuclease and deoxyribonuclease, and storage at -2 ... | 1976 | 823109 |
| synergism of immunogenic and adjuvant-active components of mycobacterial wax d in the induction of adjuvant arthritis. | two derivatives of wax d, one possessing immunogenicity and the other adjuvant activity, were tested for the possible role in the induction of adjuvant arthritis (aa) in rats. the former, a water-soluble arthritogenic and immunogenic component (wac), in incomplete freund's adjuvant, was able to induce delayed hypersensitivity (dh) and mild aa, but failed to function as an adjuvant in rats. the latter, an acetylated wax d (ad) and its subfraction, ad6, did exert adjuvant activity, but were free f ... | 1976 | 823121 |
| use of droplet plating method and cystine-lactose-lactng electrolyte-deficient medium in routine quantitative urine culturing procedure. | droplet plating of 0.01 ml of 10(-2) dilutions of mixed sonically treated urines onto cystine-lactose electrolyte-deficient agar permits formation of discrete, easily counted colonies within a small circumscribed area without interference by proteus overswarm. each colony is considered as arising from a single viable cell. the single dilution permits precise reproducible quantitation of urine bacteria population within the range 10(4) to 10(6) cells/ml of sample. droplet-plated counts were found ... | 1976 | 823176 |
| importance of isolation of nocardia in sputum of patients of tuberculosis diagnostic centre. | | 1976 | 823262 |
| separation of a water-soluble adjuvant (maf3) from delipidated cells of mycobacterium tuberculosis strain aoyama b by hydrogenolysis and gel filtration. | a water-extract from hydrogenolyzed cells of mycobacterium tuberculosis strain aoyama b was separated into four portions (f-1 to f-4 fractions) by gel filtration with a sephadex g-100 column. the third peak (called maf3) eluted from the column was the most adjuvant-active fraction. the molecular weight determined by gel filtration was around 16 000 daltons. maf3 consisted of heteropolymer(s) composed of approximately 76 to 79% neutral sugars (ara, gal, man, and glc) and 19% mucopeptide (murn, gl ... | 1976 | 823353 |
| importance of culturing lung-tissue biopsy. | | 1976 | 823435 |
| [the present significance of animal experiment and bacterial cultivation for the diagnosis of tuberculosis (author's transl)]. | | 1976 | 823540 |
| [nuclear magnetic resonance in the study of drug-sensitive and drug-resistant mycobacteria tuberculosis]. | | 1976 | 823545 |
| [meningoencephalitis caused by "anonymous" mycobacteria]. | | 1976 | 823546 |
| [current methods of microbiological diagnosis of tuberculosis]. | | 1976 | 823547 |
| [diagnostic problems in genitourinary tuberculosis (author's transl)]. | | 1976 | 823620 |
| congenital tuberculosis. | congenital tuberculosis is a rare and often fatal disease. this report concerned a premature infant in whom the disease was found after postpartum diagnosis in the mother. use of endotracheal tube aspirates to diagnose tuberculosis in the infant is a unique feature of this case. | 1976 | 823645 |
| [peracetic acid as a disinfectant in the fight against tuberculosis--experimental data-- (author's transl)]. | m. tuberculosis is susceptible to peracetic acid as a disinfectant. however, there is no unanimity how the transmission of mycobacteriaceae can be prevented and which quantitative requirements are necessary for its action. in practical work protein-like substances and varying numbers of tubercle bacilli are important in the efficacy of sputum disinfection. the tuberculocide effect of peracetic acid is scarcely influenced by such admixtures or by the number of test organisms. a preliminary attemp ... | 1976 | 823717 |
| [sensitivity tests of mycobacteria to inh, sm, emb and rmp in a semi-liquid serum-sauton-agar (author's transl)]. | in this article a simple method of sensitivity testing of mycobacteria in semi-liquid serum-sauton-agar as ahsk-test is described and first results are reported. the sensitivity to inh, sm, emb and rmp is tested. in comparative tests between the economical-test and the ahsk-test a total of 100 strains of mycobacteria of different sensitivity are investigated. the results largely agree with each other, from which the evaluation of the sensitivity test in the ahsk-test in 54% of the strains after ... | 1976 | 823718 |
| [morphological and bacteriological investigations of pulmonary apical scars (author's transl)]. | 207 apical lung pieces of 128 autopsies with macroscopical visible changes of so called pulmonary apical caps were investigated with histologic and bacteriologic methods. histologically, 19% of all cases showed tuberculous changes, 43% suspicious tuberculous changes and 38% no tuberculous changes. mycobacteria were found only in one case by bacteriological methods. the morphological results were correlated with the findings of mass chest x-ray (so-called vrru). it became evident, that half of al ... | 1976 | 823719 |
| [persistance of the agent of tuberculosis in the body as an l-form and its damging effect]. | | 1976 | 823731 |
| [role of l-forms of bacteria and mycoplasma in the etiology and pathogenesis of several acute and chronic diseases]. | | 1976 | 823732 |
| tuberculin shock in red mice and cf1 mice immunized with strains of bcg or mycobacterium tuberculosis. | groups of red mice and cf1 mice immunized intravenously with varying doses of a weak and a strong strain of bcg and a strain of m. tuberculosis were challenged 3-4 weeks later with 2 or 0.5 mg of purified tuberculin injected intravenously. the shock sensitivity of the animals in the individual groups was evaluated on the basis of the number of deaths and the survival times after challenge. in the red mice, the strain of m. tuberculosis induced a significantly greater sensitivity than the bcg str ... | 1976 | 823795 |
| recent studies in the epidemiology of tuberculosis, based on the risk of being infected with tubercle bacilli. | this review describes recent epidemiological studies, based upon the risk of infection with tubercle bacilli. in the netherlands the risk of infection has been decreasing steeply and exponentially for many years, but in some developing countries there was little secular trend in the absence of intensive control measures. variations in the risk of infection with age are being examined. a comprehensive statistical analysis has shown that the major risk of development of tuberculosis is following a ... | 1976 | 823803 |
| [application of the distal bronchial brushing technic to the bacteriological diagnosis of pulmonary tuberculosis]. | the tubercle bacillus was sought in samples obtained by bronchial brushing in 36 patients whose tuberculosis was demonstrated and in whom a direct examination of the sputum had given only negative results. in 5 cases, the tubercle bacillus was demonstrated only in the sample obtained by brushing, by direct examination and positive cultures in one case and in the other cases, culturutum coughed up after brushing. | 1976 | 823845 |
| phage type of tubercle bacilli isolated from patients with two or more sites of organ involvement. | to evaluate the possibility of separate pulmonary infections in human beings by different strains of mycobacterium tuberculosis, a search for multiple phage types within a single host was under-taken. culture isolates from 2 or more distinct anatomic sites of infection in the same patient were obtained from 87 persons. in 3 subjects, 2 distinct phage types were found. the possible explanations for 2 types in the same patient and the epidemiologic implications are discussed. | 1976 | 823847 |
| the pathogenicity of spheroplasts of mycobacterium tuberculosis. | guinea pigs were injected with spheroplasts of mycobacterium tuberculosis and were sacrificed after various intervals to study the state of the organisms and to evaluate the extent of disease. the spheroplasts persisted in the body of the animals for a considerable length of time. their presence, however, was not associated with either the development of tuberculin hypersensitivity or pathologic changes. it was found that the spheroplasts were pathogenic only when reverted in the animals to bact ... | 1976 | 823848 |
| dynamics of submerged growth of mycobacterium tuberculosis under aerobic and microaerophilic conditions. | when mycobacterium tuberculosis is grown in detergent-containing medium under continous agitation, multiplication is known to follow a logarithmic mode. when the cultures are not continuously shaken, but only agitated a few times a week to resuspend the bacilli and permit turbidity to be measured, the net increase suggests an arithmetic growth mode. it is shown here that a single pulse of aeration of an unshaken submerged culture of m. tuberculosis causes an almost instantaneous acceleration of ... | 1976 | 823851 |
| the effect of gravitational forces on the viability of spheroplasts of mycobacteria. | spheroplasts of mycobacterium smegmatis and mycobacterium tuberculosis were subjected to a wide range of centrifugal forces ranging from 583 g to 15 000 g after which their viability was determined by plating them on two types of media; one containing stabilizing agents and the other without them. though there were minor fluctuations in the viable counts, there was no consistent decrease in their viability even in the absence of osmotic stabilizers. | 1976 | 824042 |
| the management of massive hemoptysis in a patient with pulmonary tuberculosis. | | 1976 | 824102 |
| antagonistic action of streptococcus salivarius and streptococcus faecalis to mycobacterium tuberculosis. | streptococcus salivarius and streptococcus faecalis were found to inhibit the growth of mycobacterium tuberculosis on löwenstein-jensen and middlebrook 7h11 agars, but not on the latter medium when antibacterial drugs were added. s. faecalis was found to be more inhibitory than s. salivarius to 15 strains of m. tuberculosis. s. salivarius produced little or no inhibition of growth of runyon group iii organisms but was very antagonistic to runyon group i mycobacteria. | 1976 | 824304 |
| an attempt to cultivate mycobacteria in simple synthetic liquid medium containing lecithin-cholesterol liposomes. | an attempt was made to cultivate mycobacteria in a simple synthetic liquid medium containing lecithin-cholesterol liposomes. this lipid complex showed a marked growth-promoting effect on the submerged growth of m. tuberculosis and m. bovis. the role of lecithin as nutrient was suggested. the bacillary growth in such environment retained good viability, strong acid-fastness, and high virulence in mice. an avirulent strain of tubercle bacilli, h37ra, did not respond to lecithin-cholesterol liposom ... | 1976 | 824481 |
| accumulation of cholesterol esters in macrophages incubated with mycobacteria in vitro. | macrophages separated from the granulomatous lungs of tuberculous mice had a high amount of cholesterol esters. resident peritoneal macrophages of normal mice were very low in the ester content. however, when the cells were incubated with mycobacteria in hanks' solution the ester content of the mixture increased greatly. peritoneal macrophages harvested by induction with casein had a much larger amount of cholesterol esters than unstimulated resident cells. when such stimulated macrophages were ... | 1976 | 824482 |
| [selection of the method of treatment for noncavitary tuberculosis cases with negative sputum for more than 6 months based on culture findings of tubercule bacilli from resected specimens (author's transl)]. | | 1976 | 824492 |
| [immunotherapy of tuberculosis (literature review)]. | | 1976 | 824645 |
| bacterial meningitis in navojo indians. | an analysis of 219 confirmed cases of bacterial meningitis among navajo indians during a 5-year period, july 1, 1968, through june 30, 1973, revealed that 56 percent were caused by haemophilus influenzae, 26 percent by neisseria meningitidis, 6 percent by mycobacterium tuberculosis, and 6 percent by other organisms. the annual incidence of h. influenzae meningitis (17.7 per 100,000 persons) and that of pneumococcal meningitis (8.0 per 100,000) were much higher than the rates for these diseases r ... | 1976 | 824672 |
| atypical radiographic appearance and clinical presentation of pulmonary tuberculosis. | fourteen patients with unusual presentation of pulmonary tuberculosis are described. often, exposure to the tubercle bacillus was not apparent. in other cases, there was tuberculous infection or reactivation of a previous focus in individuals with altered immunity. the radiographic presentation often differed from the classic cavitating upper lobe disease. persistent pneumonia, cavities, and nodules were seen in other areas of the lung including the anterior segments and the lung bases. isolated ... | 1976 | 824742 |
| retreatment of drug-sensitive relapses of pulmonary tuberculosis following chemotherapy with standard drugs. | forty-four tuberculous patients who relapsed with strains sensitive to the initial drugs they had received, namely streptomycin and isoniazid, were retreated with the same drugs for a year. one died of tuberculosis, and two had treatment changed for unfavourable response. all the other 41 showed a bacteriological response, and all but one were culture-negative at 1 year or when last assessed. | 1976 | 824775 |
| [comparison of the efficiency of a modified ogawa medium and the media used for culture investigation on tuberculosis in routine (author's transl)]. | in cooperation of nine laboratories a modified ogawa medium containing asparagine was compared with the media used in the gdr for culture investigations on tuberculosis in routine [german pharmacopoeia (diagnostic laboratory methods) gdr]. the efficiency of the modified ogawa medium containing asparagine instead of sodiumglutamate was comparable to that of the original ogawa medium and did not show any better results. by this means it is once more evident that ogawa medium is an efficient medium ... | 1976 | 824874 |
| [presence and significance of mycobacteria in animals (proceedings)]. | | 1976 | 824890 |
| [radioimmunologic demonstration of mycobacterium tuberculosis and corresponding antibody (proceedings)]. | | 1976 | 824892 |
| adjuvant arthritis in the rat. distribution of fluorescent material after footpad injection of rhodamine-labelled tubercle bacilli. | adjuvant disease in the rat may represent a cell-mediated response to tuberculous material disseminated from the original injection site, but previous studies have provided only indirect evidence for this dissemination. in the present experiments tubercle bacilli labelled in vitro with rhodamine isothiocyanate (ritc) were injected into a footpad as freund's complete adjuvant. serial studies showed two varieties of fluorescent material in the tissues (1) intracellular and extracellular intact and ... | 1975 | 825055 |
| immunological characteristics of the armadillo, dasypus sabanicola. | the immunological responses of the armadillo are of interest because of its susceptibility to generalized lepromatoid infection with mycobacterium leprae. in this study, specimens of dasypus sabanicola were found to have a typical mammalian distribution of lymphoid cells in thymus, spleen, lymph nodes and blood. their complement was active in bactercidal, protozoan immobilization and haemolytic systems. blood lymphocytes responded to phytohaemagglutinin and to pokeweed mitogen. sensitization wit ... | 1976 | 825337 |
| discovery, chemistry, and activity of amikacin. | elucidation of the mechanism of r-factor-mediated resistance to aminoglycoside antibiotics was a noteworthy scientific achievement that led to the search for and design of new structural modifications of aminoglycosides that would render them resistant to inactivation by bacterial enzymes and increase their activity against resistant organisms. amikacin is a derivative of kanamycin a, obtained through acetylation with the l(-)-gamma-amino-alpha-hydroxybutyryl side chain at the c-1 amino group of ... | 1976 | 825583 |
| management of tuberculosis. | | 1976 | 825661 |