| inactivation of environmental mycobacteria by free chlorine and uv. | the resistance of environmental mycobacteria (em) against chlorine and ultraviolet (uv) was evaluated for determination of the ct value and uv dose to inactivate em. chlorine disinfection experiments were done on mycobacterium fortuitum in oxidant demand-free buffered water at the worst condition (ph 8.5, 4 degrees c) and normal condition (ph 7.0, 20 degrees c). the ct value for 3log inactivation of m. fortuitum was 600 times greater than that of escherichia coli. uv experiments were performed f ... | 2010 | 19945731 |
| venous catheter-associated bacteremia caused by rapidly growing mycobacteria at a medical center in central taiwan. | infections due to rapidly growing mycobacteria (rgm) are increasing worldwide, especially in immunocompromised hosts, but data on the clinical features of patients with rgm bacteremia are limited in taiwan. this study was performed to determine the features associated with rgm. | 2009 | 19949759 |
| in vitro drug susceptibility of 2275 clinical non-tuberculous mycobacterium isolates of 49 species in the netherlands. | in this study, 2275 clinical isolates of 49 species of non-tuberculous mycobacteria isolated in the netherlands were subjected to standardised drug susceptibility testing using the middlebrook 7h10 agar dilution method. clarithromycin and rifabutin were most active, with 87% and 83% of all isolates, respectively, being susceptible. susceptibility to ciprofloxacin (44%) and amikacin (32%) was limited and was mostly restricted to mycobacterium kansasii, mycobacterium xenopi, mycobacterium fortuitu ... | 2010 | 20006470 |
| design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents. | a series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against mycobacterium tuberculosis h37rv (mtb), mycobacterium smegmatis (mc(2)), and mycobacterium fortuitum following the broth micro dilution assay method. compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (inh) and rifampicin (rif) and could be ... | 2010 | 20056418 |
| activity of various drugs alone or in combination against mycobacterium fortuitum. | interest in mycobacterium fortuitum has increased since it was recognized as an emergent pathogen. the objective of this study was to screen a large number of drug combinations in order to evaluate the activity of classical and new potentially useful antibiotics against m. fortuitum. twenty m. fortuitum clinical isolates were studied with 51 combinations of two drugs and 47 combinations of three drugs belonging to different families: fluoroquinolones, linezolid, macrolides, rifamycins, aminoglyc ... | 2010 | 20063030 |
| host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease. | rapidly growing mycobacteria (rgm) are environmental organisms classified under the broader category of nontuberculous mycobacteria. the most common rgm to cause human diseases are mycobacterium abscessus, mycobacterium chelonae, mycobacterium fortuitum, and mycobacterium massiliense. infections due to the rgm are an emerging health problem in the united states. chronic pulmonary disease and skin/soft-tissue infections are the two most common disorders due to these organisms. clinical outcomes i ... | 2010 | 20081053 |
| nontuberculous mycobacterial lung disease. | there is increasing awareness that nontuberculous mycobacteria (ntm) lung diseases are becoming more prevalent. nontuberculous mycobacterial diseases could legitimately be seen as an emerging public-health threat. | 2010 | 20087178 |
| genitourinary infections caused by nontuberculous mycobacteria at a university hospital in taiwan, 1996-2008. | genitourinary infections caused by nontuberculous mycobacteria (ntm) are rarely reported. the medical records of all patients with genitourinary ntm infections treated at national taiwan university hospital from 1996-2008 were retrospectively reviewed. fifteen patients were identified, of whom 10 (67%) were male. more than two-thirds of patients had underlying conditions, the most common of which was chronic renal disease. only one patient had aids. acid-fast smears of urine were negative in all ... | 2010 | 20132253 |
| nontuberculous mycobacteria: susceptibility pattern and prevalence rate in shanghai from 2005 to 2008. | an increasing incidence of disease caused by nontuberculous mycobacteria (ntm) is being reported. the purpose of this study was to determine the isolation rates of ntm from various clinical specimens, and their antimicrobial susceptibility patterns, over a 4-year period in shanghai. | 2010 | 20137367 |
| high efficacy of clofazimine and its synergistic effect with amikacin against rapidly growing mycobacteria. | the aim of this study was to determine whether clofazimine, dapsone and cycloserine may be suitable antimicrobial agents for the treatment of infections due to rapidly growing mycobacteria (rgm). the antimicrobial activity of the three drugs against 117 mycobacterium abscessus isolates, 48 mycobacterium fortuitum isolates and 20 mycobacterium chelonae isolates was evaluated based on their broth microdilution minimal inhibitory concentrations (mics) against the isolates. clofazimine was highly ef ... | 2010 | 20138481 |
| lung disease caused by nontuberculous mycobacteria. | although the incidence of tuberculosis has reduced in developed countries, there is a growing interest in nontuberculous mycobacteria (ntm) as a cause of lung disease. however, ntm are a heterogeneous group and most of the data come from only three species: mycobacterium avium complex, mycobacterium kansasii and mycobacterium abscessus. still, information about these three species is confusing because it is based mainly on retrospective studies and series of clinical cases performed in developed ... | 2010 | 20154623 |
| [cutaneous and soft skin infections due to non-tuberculous mycobacteria]. | the frequency of isolation as well as the number of species of non-tuberculous mycobacteria (ntm) has increased in the last years. nearly every pathogenic species of ntm may cause skin and soft tissue infections, but rapidly growing mycobacteria (mycobacterium fortuitum, mycobacterium chelonae and mycobacterium abscessus), mycobacterium marinum and mycobacterium ulcerans are the most commonly involved. many of these cutaneous mycobacteriosis, such as rapidly growing mycobacteria, m. marinum, myc ... | 2010 | 20172423 |
| [clinical features of pneumothorax in patients with active nontuberculous mycobacterial lung disease]. | this study was retrospectively conducted to clarify the clinical features of pneumothorax in patients with active nontuberculous mycobacterial (ntm) lung disease. the patients were 9 men and 7 women, with a median age of 70. pathogenic mycobacteria were 12 mycobacterium avium complex, 2 mycobacterium kansasii, and 2 mycobacterium fortuitum. more than one lung field was affected by ntm disease in 11 patients, whereas 4 patients were given a diagnosis of mild ntm disease only at the onset of pneum ... | 2010 | 20184239 |
| in vitro activity of a new isothiazoloquinolone, ach-702, against mycobacterium tuberculosis and other mycobacteria. | in this work, we describe the activity of ach-702 against clinical isolates of mycobacterium tuberculosis and six different nontuberculous mycobacteria. the mic(50) and mic(90) of both susceptible and drug-resistant m. tuberculosis strains tested were 0.0625 and 0.125 microg/ml, respectively. the mic(50) and mic(90) values for mycobacterium fortuitum isolates were 0.0625 microg/ml in both cases; mycobacterium avium complex isolates showed mic(50) and mic(90) values of 0.25 and 4 microg/ml, respe ... | 2010 | 20231398 |
| predominance of mycobacterium fortuitum-chelonae complex in ghatampur field area, endemic for leprosy. | non-tuberculous mycobacteria (ntm) are commonly found in the environment. as exposure to environmental mycobacteria has been reported to immunomodulatory in this study, the presence of environmental mycobacteria was investigated in soil, drinking water and drainage sample in ghatampur, india, which is known for high endemicity for leprosy. soil, drinking water from the hand pumps/wells and also drainage water collected in pools was collected in clean containers and cultured for environmental myc ... | 2008 | 20329381 |
| mycobacterium fortuitum infections associated with laparoscopic gastric banding. | mycobacterium fortuitum, a rapidly growing atypical mycobacteria, is commonly found in soil and water. this organism is most often known to cause skin, bone, and soft tissue infections associated with local trauma, surgical procedures, and in patients with immunodeficiency. nosocomial infections associated with a variety of contaminated devices and equipment have also been widely documented. this report presents the first cases of m. fortuitum infection following laparoscopic gastric banding pro ... | 2011 | 20336391 |
| peritonitis due to mycobacterium fortuitum following gastric banding. | mycobacterium fortuitum is a rapid growing nontuberculous organism that has rarely been associated with peritonitis in an otherwise healthy host. we describe a patient who developed peritonitis due to the organism after gastric banding operation, which resolved after removal of the gastric band and institution of appropriate antibiotic therapy. | 2010 | 20339182 |
| in vitro activities of dc-159a, a novel fluoroquinolone, against mycobacterium species. | the in vitro activities of dc-159a against seven species of mycobacterium were compared with moxifloxacin, gatifloxacin, levofloxacin, and rifampin. dc-159a was the most active compound against quinolone-resistant multidrug-resistant m. tuberculosis (mic(90), 0.5 microg/ml) as well as drug-susceptible isolates (mic(90), 0.06 microg/ml). the anti-tubercle bacilli activity of dc-159a was 4- to 32-fold more potent than those of currently available quinolones. dc-159a also demonstrated the highest a ... | 2010 | 20368403 |
| in vitro antibiotic susceptibility of rapidly growing nontuberculous mycobacteria isolated from patients with microbial keratitis. | this study was undertaken to determine the antibiotic susceptibility and minimum inhibitory concentrations (mic) of amikacin, tobramycin, ciprofloxacin, gatifloxacin, azithromycin, and clarithromycin against rapidly growing nontuberculous mycobacteria isolated from patients with keratitis. | 2010 | 20373881 |
| mycobacterium fortuitum infection following patellar tendon repair: a case report. | | 2010 | 20439674 |
| utility of high-performance liquid chromatography analysis of mycolic acids and partial 16s rrna gene sequencing for routine identification of mycobacterium spp. in a national reference laboratory. | high-performance liquid chromatography analysis of mycolic acids and partial gene sequencing for the first 500-bp 5' end of the 16s rrna gene were used singularly and in combination to evaluate the final identification of species. examination of 200 cultures revealed 100 strains of slowly growing mycobacteria (sgm), 91 strains of rapidly growing mycobacteria (rgm), and 9 strains of other genera. sgm were discriminated in complexes with both methods for 56 strains, composed primarily of the mycob ... | 2010 | 20466195 |
| [a first case of non-tuberculous mycobacterial disease caused by mycobacterium septicum accompanied with tuberculous subcutaneous abscess]. | | 2010 | 20491285 |
| hansen's disease (leprosy) complicated by secondary mycobacterial infection. | a patient with hansen's disease received corticosteroids for a type 1 leprosy reaction and subsequently developed a new cutaneous lesion at the original biopsy site from which mycobacterium fortuitum was cultured. a review of the literature found only two other cases of coinfection with atypical mycobacteria and mycobacterium leprae, although there are many reports of pulmonary tuberculosis in patients with leprosy. this case highlights the diagnostic difficulties encountered when a patient has ... | 2011 | 20494478 |
| images in clinical medicine. piercing-related nontuberculous mycobacterial infection. | | 2010 | 20505180 |
| subcutaneous aspergillosis with coexisting atypical mycobacterial infection. | a 60-year-old woman, a known diabetic and asthmatic, was admitted for acute exacerbation of chronic obstructive pulmonary disease. physical examination revealed two soft nodules in the left infra axillary region. fine needle aspiration cytology (fnac) showed fungal granulomatous reaction suggestive of fungal infection. periodic acid schiff stain (pas stain) revealed pas positive, acutely branching, septate fungal hyphae. wet mount of the aspirate revealed plenty of pus cells and branching septat ... | 2010 | 20551559 |
| mycobacterium conceptionense infection after breast implant surgery, france. | | 2010 | 20587205 |
| multiple cutaneous squamous cell carcinomas in a patient with interferon gamma receptor 2 (ifn gamma r2) deficiency. | disseminated squamous cell carcinoma (scc) of the skin is exceedingly rare in children. scc occurs after immunodeficiency from immunosuppression in organ transplant recipients or patients with hiv infection or leukaemia, but has not been reported in primary immunodeficiencies other than epidermodysplasia verruciformis. interferon gamma receptor 2 (ifn gamma r2) deficiency is an exceedingly rare primary immunodeficiency, conferring almost selective predisposition to mycobacterial diseases. a diss ... | 2010 | 20587411 |
| skin and soft-tissue infection caused by non-tuberculous mycobacteria in taiwan, 1997-2008. | the aim of this study was to investigate the clinical, microbiological, and pathological characteristics and the outcomes of skin and soft-tissue infection (ssti) caused by non-tuberculous mycobacteria (ntm). medical records of 50 patients with ssti caused by ntm identified from 2005 to 2008 and 63 patients previously reported in a medical centre from 1997 to 2004 were reviewed. the annual incidence (per 100,000 outpatients and in-patients) ranged from 0·57 in 2005, 0·38 in 2007, to 1·1 in 2008, ... | 2011 | 20598210 |
| susceptibility of rapidly growing mycobacteria isolated from cats and dogs, to ciprofloxacin, enrofloxacin and moxifloxacin. | rapidly growing mycobacteria (rgm) cause infections in cats and dogs which require prolonged antibacterial medication for resolution. in australia, pathogens from the mycobacterium fortuitum and mycobacterium smegmatis clusters are responsible for most of the rgm infections in cats and dogs. as fluoroquinolones are often recommended for treating such infections, 14 m. fortuitum isolates, 51 isolates from the m. smegmatis cluster and 2 m. mageritense isolates, collected from feline and canine pat ... | 2011 | 20619975 |
| occurrence of mycobacterium spp. and other pathogens in lymph nodes of slaughtered swine and wild boars (sus scrofa). | mycobacterium spp. and other pathogens were investigated in 258 swine lymph nodes (129 with and 129 without apparent lesions), and 120 lymph nodes (60 with and 60 without lesions) from wild boars (sus scrofa). a total of lymph nodes from swine and wild boars were collected of different animals. submaxillar and mesenteric lymph nodes were submitted to microbiological examination and colonies suggestive of mycobacterium spp. (alcohol-acid bacilli) were submitted to pcr restriction assay (pra). in ... | 2011 | 20621319 |
| antibiotic susceptibility pattern of rapidly growing mycobacteria. | the rapidly growing mycobacteria (rgm) causing human infections primarily consist of the mycobacterium fortuitum group, mycobacterium abscessus and mycobacterium chelonae. the antibiotic susceptibility testing is important to determine the appropriate therapy as the antibiotics used to treat rgm are different from those used for treating infections caused by slow growers of mycobacteria. | 2010 | 20622384 |
| liquid vs. solid culture for tuberculosis: performance and cost in a resource-constrained setting. | national health laboratory services tuberculosis (tb) laboratory, south africa. | 2010 | 20626948 |
| mycobacterium chelonae and mycobacterium fortuitum infection following open fracture: a case report and review of the literature. | we report a case of dual nontuberculous mycobacterial infections complicating an open distal radius and ulna fracture after polytrauma in a 35-year-old man. there was persistent wound discharge after definitive fixation of this fracture, but microbiological cultures did not yield any organism. the patient underwent multiple debridement, and subsequent tissue grew mycobacterium chelonae and mycobacterium fortuitum. despite appropriate chemotherapy and surgical debridement the infection persisted ... | 2010 | 20644316 |
| measurement of the rates of synthesis of three components of ribosomes of mycobacterium fortuitum: a theoretical approach to qrt-pcr experimentation. | except for the ribosomal protein l12 (rpll), ribosomal proteins are present as one copy per ribosome; l12 (rpll) is unusual because it is present as four copies per ribosome. thus, the strategies used by mycobacterium fortuitum to regulate ribosomal protein synthesis were investigated, including evaluations of the rates of chain elongations of 16s rrna, rpll and ribosomal protein s12 (rpsl). | 2010 | 20644643 |
| effects of photodynamic therapy on rapidly growing nontuberculous mycobacteria keratitis. | the authors investigated the antimicrobial effect of methylene blue (mb)-mediated photodynamic therapy (pdt) on mycobacterium fortuitum keratitis. | 2011 | 20811055 |
| soft tissue infection due to mycobacterium fortuitum following acupuncture: a case report and review of the literature. | we report the first case of a post-acupuncture soft tissue infection due to mycobacterium fortuitum. two months after finishing an acupuncture treatment session, an immunocompetent 23-year-old woman developed cellulitis at the side of the needle insertions and the acid-fast bacillus was isolated from a closed abscess. the patient was successfully treated with a proper drug combination. we review the literature concerning the infection source and the risks for skin and soft tissue infection due t ... | 2010 | 20818105 |
| breast infections with atypical mycobacteria following reduction mammaplasty. | reduction mammaplasty is one of the most common plastic surgery procedures performed in the us, with the goal of correcting symptomatic macromastia. more than 70,000 cases were performed in 2009, with few complications and low infection rates. the authors present two cases of breast infections with mycobacterium fortuitum and one with mycobacterium chelonei following bilateral reduction mammaplasty. infection with these organisms is exceptionally rare following breast surgery in the absence of a ... | 2010 | 20829252 |
| control of mycobacterium fortuitum and mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of balb/c mice. | mycobacterium fortuitum is a rapidly growing nontuberculous mycobacterium that can cause a range of diseases in humans. complications from m. fortuitum infection have been associated with numerous surgical procedures. a protective immune response against pathogenic mycobacterial infections is dependent on the granuloma formation. within the granuloma, the macrophage effector response can inhibit bacterial replication and mediate the intracellular killing of bacteria. the granulomatous responses ... | 2010 | 20835610 |
| light insensitive silver(i) cyanoximates as antimicrobial agents for indwelling medical devices. | ten silver(i) cyanoximates of agl composition (l = nc-c(no)-r, where r is electron withdrawing groups: -cn, -c(o)nr(2), -c(o)r' (alkyl), -c(o)oet, 2-heteroaryl fragments such as 2-pyridyl, 2-benzimidazolyl, 2-benzoxazolyl, 2-benzthiazolyl) were synthesized and characterized using spectroscopic methods and x-ray analysis. crystal structures of four complexes were determined and revealed the formation of two-dimensional (2d) coordination polymers of different complexity in which anions exhibit bri ... | 2010 | 20873734 |
| the use of quaternary ammonium disinfectants selects for persisters at high frequency from some species of non-tuberculous mycobacteria and may be associated with outbreaks of soft tissue infections. | non-tuberculous mycobacteria (ntm) are increasingly important as opportunistic infections after major and minor surgical procedures, likely because they are ubiquitous and not effectively killed by many commonly used disinfectants. outbreaks of soft tissue infections with ntm appeared related to the use of commercial disinfectants based on quaternary ammonium compounds (qacs). | 2010 | 20926395 |
| mycobacterium fortuitum in cutaneous infections. | three cases of culture proven primary cutaneous infections caused by mycobacterium fortuitum, a rapidly growing non tuberculous mycobacterium, are reported. the first case was treated with ciprofloxacin and the other two, with trimethoprim / sulphamethoxazole with an excellent outcome. | 1997 | 20944384 |
| phenotypic and genotypic characteristics of mycobacterium isolates from fighting fish betta spp. in malaysia. | mycobacteriosis due to mycobacteria is one of the most common bacterial diseases in ornamental fish. we describe here the phenotypic and genotypic characteristics of mycobacterium isolates from fighting fish betta spp. using atcc mycobacterium marinum, mycobacterium fortuitum and mycobacterium chelonae as references. a total of four isolates (m1, m2, m3, m4) were obtained from four out of 106 fish samples using selective agar, and identified to mycobacterium genus using acid-fast staining and 16 ... | 2010 | 20971487 |
| non-tuberculous mycobacterial infections of the skin: a retrospective study of 29 cases. | the incidence of infections caused by non-tuberculous mycobacteria has increased in recent years, due to a rise in dermatological procedures and a greater prevalence of immunosuppression in the general population. this study investigated the clinical and microbiological findings of non-tuberculous mycobacterial skin infections. the study population included 29 patients from whom non-tuberculous mycobacteria were cultured after isolation from skin biopsy materials, cutaneous abscesses or exudates ... | 2010 | 21039785 |
| [identification and isolation of non-tuberculous mycobacteria from environmental samples.] | non-tuberculous mycobacteria (ntm) found frequently in tap water and environment cause important opportunistic infections in immunocompromised patients. the aim of this study was to isolate and identify non-tuberculous mycobacteria in soil, raw milk and water distribution system samples in mersin (a province located at mediterranean region of turkey). a total of 101 water, 124 soil and 40 milk samples collected from the central part and suburban parts of mersin during november 2003-may 2004 peri ... | 2010 | 21063989 |
| design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4(1h)-quinolones. | a series of 23 new 1-methyl-2-alkenyl-4(1h)quinolones have been synthesized and evaluated in vitro for their antimycobacterial activities against fast growing species of mycobacteria, such as mycobacterium fortuitum, m. smegmatis and m. phlei. the compounds displayed good to excellent inhibition of the growth of the mycobacterial test strains with improved antimycobacterial activity compared to the hit compound, evocarpine. the most active compounds, which possessed chain length of 11-13 carbons ... | 2010 | 21106378 |
| approaches towards optimising the gamma interferon assay for diagnosing mycobacterium bovis infection in african buffalo (syncerus caffer). | the application of diagnostic tests for bovine tuberculosis in wildlife poses formidable technical difficulties and the use of the gamma interferon assay offers a simplified approach to testing wild animal species. we compared the performance of the gamma interferon assay in african buffalo (syncerus caffer) under the recommended guidelines for interpretation of test results and found a high sensitivity (92.1%) at the cost of a greatly reduced specificity (68.3%). the optimised cut-off value for ... | 2010 | 21122932 |
| mycobacterium immunogenum skin infections: two different presentations. | | 2010 | 21128921 |
| mycobacterium fortuitum and mycobacterium chelonae biofilm formation under high and low nutrient conditions. | the rapidly growing mycobacteria (rgm) are broadly disbursed in the environment. they have been recovered from freshwater, seawater, wastewater and even potable water samples and are increasingly associated with non-tuberculous mycobacterial disease. there is scant evidence that non-tuberculous mycobacteria (ntm) and rgm form biofilms. therefore, an experimental system was designed to assess the ability of rgm to form biofilms under controlled laboratory conditions. a flat plate reactor flow cel ... | 1998 | 21182694 |
| pathology in practice. cutaneous mycobacteriosis. | | 2011 | 21235368 |
| the clinical course of rapidly growing nontuberculous mycobacterial peritoneal dialysis infections in asians: a case series and literature review. | peritoneal dialysis (pd)-related infections due to rapidly growing nontuberculous mycobacterium (rgntm) are rare in asians and have variable clinical outcomes. | 2011 | 21272129 |
| mycobacterium fortuitum from lesions of slaughtered pigs in ibadan, nigeria. | to ascertain the cause of tuberculous-like lesions in pigs slaughtered in a local abattoir in ibadan (south-western nigeria), a total of 516 pigs were inspected over a period of four months, 18 of which had gross lesions suggestive of tuberculosis at post-mortem. mycobacterial culture and molecular typing (genotype mycobacterium cm [common mycobacteria] assay) analysis were used to identify and confirm the mycobacteria species responsible for these lesions. results show that 2.3% (12/516) of the ... | 2010 | 21309469 |
| synthesis and biological evaluation of analogues of akt (protein kinase b) inhibitor-iv. | inhibitors of the pi3-kinase/akt (protein kinase b) pathway are under investigation as anticancer and antiviral agents. the benzimidazole derivative akt inhibitor-iv (chembridge 5233705) affects this pathway and exhibits potent anticancer and antiviral activity. to probe its biological activity, we synthesized akt inhibitor-iv and 21 analogues using a novel six-step route based on zrcl(4)-catalyzed cyclization of 1,2-arylenediamines with a,ß-unsaturated aldehydes. we examined effects on viabilit ... | 2011 | 21319800 |
| importance of antibiotic penetration in the antimicrobial resistance of biofilm formed by non-pigmented rapidly growing mycobacteria against amikacin, ciprofloxacin and clarithromycin. | to study the resistance of biofilms developed by non-pigmented rapidly growing mycobacteria (nprgm) against amikacin, ciprofloxacin and clarithromycin in an in vitro model using clinical strains of different species. | 2011 | 21333405 |
| an unusual case of a cervical mass due to nontuberculous mycobacterium fortuitum infection. | mycobacterium fortuitum, of the class of nontuberculous mycobacteria, rarely causes cervical lymphadenopathy and head and neck masses. however, we treated a woman with a neck mass that was indeed caused by a mycobacterial infection. our case is unique in that prompt recognition of the infection and treatment with antimicrobials averted surgery. generally, both antibiotics and surgery are recommended, and in rare instances, infections can resolve with antibiotics alone. nontuberculous m fortuitum ... | 2008 | 21339921 |
| development of multiplex pcr assays based on the 16s-23s rrna internal transcribed spacer for the detection of clinically relevant nontuberculous mycobacteria. | to accelerate the identification and differentiation of clinically relevant nontuberculous mycobacteria (ntm) with two sets of multiplex pcr (mpcr) targeting the 16s-23s rrna internal transcribed spacer (its) region for timely patient management. | 2011 | 21395629 |
| synthesis of n-substituted 2-[(1e)-alkenyl]-4-(1h)-quinolone derivatives as antimycobacterial agents against non-tubercular mycobacteria. | in an effort to improve biological activities and to examine antimycobacterial-lipophilicity relationships of 2-[(1e)-alkenyl)]-4-(1h)-quinolones, we have synthesized a series of 30 quinolones by introducing several alkyl groups, an alkenyl and an alkynyl group at n-1. all synthetic compounds were first tested in vitro against mycobacterium smegmatis and the most active compounds (mic values ~3.0-7.0 µm) were further examined against three other rapidly growing strains of mycobacteria using a mi ... | 2011 | 21429630 |
| pleural effusion in an immunocompetent woman caused by mycobacterium fortuitum. | mycobacterium fortuitum is a non-tuberculous mycobacterium that can cause pneumonia, abscess and empyema in subjects with predisposing lung diseases. however, pleurisy with effusion is rare. herein, we report the case of a 74-year-old immunocompetent female patient without apparent risk factors, who suffered haemorrhagic pleural effusion as the main clinical manifestation. pleural nodules were detected by computed tomography scan, and microbiological analysis revealed m. fortuitum in the absence ... | 2011 | 21459911 |
| new quinolin-4-yl-1,2,3-triazoles carrying amides, sulphonamides and amidopiperazines as potential antitubercular agents. | three new series of quinoline-4-yl-1,2,3-triazoles carrying amides, sulphonamides and amidopiperazines were synthesized through multi-step reactions. the required intermediate, [1-(6-methoxy-2-methylquinolin-4-yl)-1h-1,2,3-triazol-4-yl]methanol (2) was prepared by treating 4-azido-6-methoxy-2-methylquinoline (1) with propargyl alcohol. three different series of compounds were synthesized from this intermediate. all the newly synthesized compounds were characterized by spectral and elemental anal ... | 2011 | 21489660 |
| chronic breast abscess due to mycobacterium fortuitum: a case report. | abstract: introduction: mycobacterium fortuitum is a rapidly growing group of nontuberculous mycobacteria more common in patients with genetic or acquired causes of immune deficiency. there have been few published reports of mycobacterium fortuitum associated with breast infections mainly associated with breast implant and reconstructive surgery. case presentation: we report a case of a 51-year-old caucasian woman who presented to our one-stop breast clinic with a two-week history of left breast ... | 2011 | 21592364 |
| nasal infection due to mycobacterium fortuitum. | introduction: mycobacterium fortuitum, a rapidly growing non-tuberculous atypical mycobacterium, is commonly found in soil and water. this organism generally causes skin, bone, and soft tissue infections following local trauma or surgical procedures, and in immunodeficient patients. the case reported here is, to our knowledge, the first published report of m. fortuitum nasal infection. case report: the authors report the case of a 3-year-old girl with intranasal tumour-like swelling associated w ... | 2011 | 21596645 |
| interaction of n-methyl-2-alkenyl-4-quinolones with atp-dependent mure ligase of mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. | objectives the aim of this study was to comprehensively evaluate the antibacterial activity and mure inhibition of a set of n-methyl-2-alkenyl-4-quinolones found to inhibit the growth of fast-growing mycobacteria. methods using the spot culture growth inhibition assay, mics were determined for mycobacterium tuberculosis h(37)rv, mycobacterium bovis bcg and mycobacterium smegmatis mc(2)155. mics were determined for mycobacterium fortuitum, mycobacterium phlei, methicillin-resistant staphylococcus ... | 2011 | 21622974 |
| bone marrow infection with mycobacterium fortuitum in a diabetic patient. | incidence and prevalence of mycobacterium fortuitum infection vary greatly by location and death is very rare except in disseminated disease in immunocompromised individuals. we present what we believe is the first case of bone marrow infection with mycobacterium fortuitum in an hiv negative patient. bone marrow examination revealed presence of numerous acid fast bacilli which were confirmed as mycobacterium fortuitum on culture and by molecular analysis. patient was managed successfully with am ... | 2011 | 21798140 |
| species identification of neglected nontuberculous mycobacteria in a developing country. | in developing countries where tuberculosis is still a health challenge, the prevalence of nontuberculous mycobacterial diseases is expected to rise as medical conditions that compromise the immune system become more widespread. in the current study, we aimed to determine the presence and diversity of nontuberculous mycobacteria (ntm) causing infections in iranian patients. sixty-seven clinical ntm isolates were identified using conventional and molecular methods, including pcr-restriction fragme ... | 2011 | 21788699 |
| mycobacterium fortuitum misidentified as corynebacterium jeikeium in catheter-related bloodstream infection. | | 2011 | 21784558 |
| canaliculitis involving mycobacterium fortuitum after dacryocystorhinostomy with silicone stenting. | | 2011 | 21784223 |
| susceptibility of rapidly growing mycobacteria and nocardia isolates from cats and dogs to pradofloxacin. | rapidly growing mycobacteria (rgm) and nocardiae can cause severe or refractory infections in cats and dogs. prolonged antibacterial therapy is required to cure these infections. as fluoroquinolones have been used in combination therapy for treating rgm infections, isolates from the mycobacterium smegmatis cluster (n=64), mycobacterium fortuitum cluster (n=17), and m. mageritense cluster (n=2), collected from feline and canine patients, underwent susceptibility testing to pradofloxacin. the mic( ... | 2011 | 21726965 |
| mycobacterium fortuitum infection following adalimumab treatment for psoriasis and subsequent complication-free treatment with alternate tnf-a blockers. | tumor necrosis factor-a (tnf-a) inhibitors, such as adalimumab, are often used to treat psoriasis and psoriatic arthritis. while it is well known that these agents increase the risk of reactivation tuberculosis, recent evidence suggests that the risk of other nontuberculous mycobacterial (ntm) infections is on the rise. we report cutaneous mycobacterium fortuitum in a 60-year-old woman with psoriasis who had been receiving adalimumab therapy for psoriatic arthritis for six months. no other risk ... | 2011 | 21818515 |
| molecular cloning, purification, and characterization of a superoxide dismutase from a fast-growing mycobacterium sp. strain jc1 dsm 3803. | a cytosolic superoxide dismutase (sod) was purified and characterized from a fast-growing mycobacterium sp. strain jc1 dsm 3803 grown on methanol. the native molecular weight of the purified sod was estimated to be 48 kda. sds-page revealed a subunit of 23 kda, indicating that the enzyme is a homodimer. the enzyme activity was inhibited by h(2)o(2) and azide. the purified sod contained 1.12 and 0.56 g-atom of mn and fe per mol of enzyme, respectively, suggesting that it may be a fe/mn cambialist ... | 2011 | 21717325 |
| antifungal, antibacterial and antimycobacterial activity of entada abysinnica steudel ex a. rich (fabaceae) methanol extract. | the purpose of the study was to investigate the antifungal, antibacterial and antimycobacterial properties of methanol extract of entada abysinnica steudel ex. a. rich (fabaceae) leaves used by herbalists from the lake victoria region, kenya. the extract was tested against four strains of mycobacteria (mycobacterium tuberculosis, mycobacterium kansasii, mycobacterium fortuitum, and mycobacterium smegmatis) using bactec mycobacteria growth indicator tube (mgit) 960 system and the proportional met ... | 2010 | 21808560 |
| mycobacterium marinum infections in humans and tracing of its possible environmental sources. | the low frequency of nontuberculous mycobacterial infections, nonspecific symptoms for individual mycobacteria, and the lack of specific identification methods could alter correct diagnosis. this study presents a combined microbiology and molecular-based approach for mycobacterium marinum detection in four aquarists with cutaneous mycobacterial infection. simultaneously, ecology screening for m. marinum presence in the aquarists' fish tanks was performed. a total of 38 mycobacterial isolates o ... | 2011 | 22182182 |
| Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis. | Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing. | 2011 | 22032579 |
| peritoneal dialysis-associated nontuberculous mycobacterium peritonitis: a systematic review of reported cases. | background: peritonitis caused by nontuberculous mycobacterium (ntm) is an important complication in peritoneal dialysis (pd) patients.methods: cases of pd complicated by ntm peritonitis reported in the english language literature were identified in the pubmed database. the characteristics of these cases were reviewed.results: in 41 articles, we identified 57 cases of pd-associated ntm peritonitis in patients ranging from 5 to 82 years. the prevalent clinical findings of these cases were fever, ... | 2011 | 21891775 |
| septic arthritis caused by mycobacterium fortuitum and mycobacterium abscessus in a prosthetic knee joint: case report and review of literature. | nontuberculous mycobacterium (ntm) is an infrequent cause of prosthetic knee joint infections. simultaneous infection with different ntm species in a prosthetic knee joint has not been previously reported. a case of prosthetic knee joint infection caused by mycobacterium abscessus and m. fortuitum is described in this report. the patient was successfully treated with adequate antibiotics and surgery. the clinical features of sixteen previously reported cases of prosthetic knee joint infection ca ... | 2011 | 21963746 |
| Comparative study with two different enrichments in the culture media used in the disinfectant efficacy assay. | Recent changes in Brazilian legislation for commercial disinfectants have been published due to the recent epidemic of nosocomial infections caused by rapidly growing mycobacteria (RGM) in many states of Brazil over the last 8years. One of these documents requires that all the manufacturers provide evidence of efficacy of sterilizing and disinfectant products, used for semi critical medical devices, against the Mycobacterium bovis BCG Moreau and Mycobacterium abscessus subsp. bolletii INCQS 0059 ... | 2011 | 22197720 |
| mycobacterium fortuitum prosthetic valve endocarditis: a case for the pathogenetic role of biofilms. | background: prosthetic valve endocarditis presents unique challenges for both diagnosis and treatment. a potential role of biofilm has been hypothesized in the pathogenesis of these infections. methods: a patient with infective endocarditis involving a stentless (freestyle) porcine prosthetic aortic valve with annular abscess and paravalvular leak 8 months after implantation is reported. results: the infected valve did not show vegetations or perforations, but histiocytic inflammation was seen a ... | 2011 | 22196518 |
| intrathecal drug delivery device infection and meningitis due to mycobacterium fortuitum: a case report. | intrathecal drug delivery device infection with mycobacterium fortuitum has not been reported previously. we report a case of an implanted baclofen pump infection and associated mycobacterium meningitis due to mycobacterium fortuitum. the entire pump system was removed and the patient was treated successfully with a prolonged regimen of antibiotics. | 2008 | 22151146 |
| Identification and treatment of nontuberculous Mycobacterium sinusitis. | The purpose of this study was to identify the incidence of atypical Mycobacterium identified by routine sinus cultures and review the recent literature on management. | 2011 | 22185748 |
| Mycobacterium mucogenicum and other non-tuberculous mycobacteria in potable water of a trauma hospital: a potential source for human infection. | This study examined the frequency of occurrence of non-tuberculous mycobacteria (NTM) in potable water samples from a main trauma hospital in Mexico City. Sixty-nine potable water samples were collected, 23 from each source: cistern, kitchen tap and bathroom showers. Of the 69 samples, 36 harboured NTM species. Twenty-nine of the 36 isolates were Mycobacterium mucogenicum, two Mycobacterium rhodesiae, one Mycobacterium peregrinum, one Mycobacterium fortuitum and three were Mycobacterium spp. Hos ... | 2012 | 22055394 |
| Antibacterial spectrum and cytotoxic activities of serrulatane compounds from the Australian medicinal plant Eremophila neglecta. | Aims: To determine the antibacterial spectrum and cytotoxic activities of serrulatane compounds from the Australian plant Eremophila neglecta. Methods and Results: Antimicrobial activities of serrulatane compounds 8,19-dihydroxyserrulat-14-ene (1) and 8-hydroxyserrulat-14-en-19-oic acid (2) were tested against Gram-negative and Gram-positive bacteria including human and veterinary pathogens and some multidrug-resistant isolates. Minimum inhibitory concentrations (MICs) and minimum bactericidal ... | 2012 | 21988135 |
| [Breast implant infection by Mycobacterium fortuitum in a patient with systemic lupus erythematosus]. | In recent decades there has been an increase in the number of breast implants for reconstruction and cosmetic purposes. Infection is a severe complication mostly caused by Staphylococcus aureus or coagulase-negative staphylococci. Mycobacteria are an infrequent cause of infection in this type of surgery. We describe a case of Mycobacterium fortuitum infection in a patient with lupus, subjected to a prosthetic replacement. These patients are more prone to unusual opportunistic infections. Treatme ... | 2011 | 22051625 |
| molecular identification and typing of mycobacterium massiliense isolated from postsurgical infections in brazil. | one hundred thirty-one cases of postsurgical infections were reported in southern region of brazil between august 2007 and january 2008. thirty-nine (29.8%) cases were studied; this report describes epidemiological findings, species identification, antimicrobial susceptibility and clonal diversity of rapidly growing mycobacteria isolated in this outbreak. | 2011 | 22230849 |
| deletion of the entire interferon-γ receptor 1 gene causing complete deficiency in three related patients. | complete interferon-γ receptor 1 (ifn-γr1) deficiency is a primary immunodeficiency causing predisposition to severe infection due to intracellular pathogens. only 36 cases have been reported worldwide. the purpose of this article is to describe a large novel deletion found in 3 related cases, which resulted in the complete removal of the ifngr1 gene. | 2016 | 26931784 |
| in vitro activity of tp-271 against mycobacterium abscessus, mycobacterium fortuitum, and nocardia species. | the in vitro activities of tp-271, a novel fluorocycline antimicrobial, against 22 isolates of mycobacterium abscessus, 22 isolates of mycobacterium fortuitum, and 19 isolates of nocardia spp. were studied by a microtiter broth dilution method. the mic(90)s for m. abscessus, m. fortuitum, and nocardia spp. were 0.5 μg/ml, 0.03 μg/ml, and 8 μg/ml, respectively. tp-271 was significantly more active than the respective control drug in virtually all tests. | 2012 | 22585214 |
| enzymatic degradation of phenazines can generate energy and protect sensitive organisms from toxicity. | diverse bacteria, including several pseudomonas species, produce a class of redox-active metabolites called phenazines that impact different cell types in nature and disease. phenazines can affect microbial communities in both positive and negative ways, where their presence is correlated with decreased species richness and diversity. however, little is known about how the concentration of phenazines is modulated in situ and what this may mean for the fitness of members of the community. through ... | 2015 | 26507234 |
| properties of catechol 1,2-dioxygenase in the cell free extract and immobilized extract of mycobacterium fortuitum. | polycyclic aromatic hydrocarbons (pah) are carcinogenic compounds which contaminate water and soil, and the enzymes can be used for bioremediation of these environments. this study aimed to evaluate some environmental conditions that affect the production and activity of the catechol 1,2-dioxygenase (c12o) by mycobacterium fortuitum in the cell free and immobilized extract in sodium alginate. the bacterium was grown in mineral medium and lb broth containing 250 mg l(-1) of anthracene (pah). the ... | 2013 | 24159319 |
| penicillium chrysogenum dsoa associated with marine sponge (tedania anhelans) exhibit antimycobacterial activity. | a strain of penicillium chrysogenum was isolated from tedania anhelans (marine sponge) collected from indian ocean (8°22'30″n latitude and 76°59'16″ longitude) and deposited in culture collection centers. the strain subjected to different culture conditions for production of extrolites were extracted using ethyl acetate and chloroform. when both extracts were subjected for antibacterial activity, latter had high activity. minimum inhibitory concentration of chloroform extract ranged from 31.25-1 ... | 2016 | 26717859 |
| synthesis and characterization of new n-(4-(4-chloro-1h-imidazol-1-yl)-3-methoxyphenyl)amide/sulfonamide derivatives as possible antimicrobial and antitubercular agents. | in this paper we report the sar studies of a series of n-(4-(4-chloro-1h-imidazol-1-yl)-3-methoxyphenyl)amide and n-(4-(4-chloro-1h-imidazol-1-yl)-3-methoxyphenyl)sulfonamide derivatives 6(a-o) and 7(a-o), were synthesized in good yields and characterized by (1)h nmr, (13)c nmr and mass spectral analyses. the preparation of the key intermediate highlights an optimized palladium catalyzed (pd₂(dba)₃/ruphos) buchwald cross-coupling of intermediate 2 and 3. the newly synthesized compounds were eval ... | 2014 | 24361479 |
| design and synthesis of positional isomers of 5 and 6-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1h-benzimidazoles as possible antimicrobial and antitubercular agents. | in this letter, we report the structure-activity relationship (sar) studies on series of positional isomers of 5(6)-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1h-benzimidazoles derivatives 7(a-j) and 8(a-j) synthesized in good yields and characterized by (1)h nmr, (13)c nmr and mass spectral analyses. the crystal structure of 7a was evidenced by x-ray diffraction study. the newly synthesized compounds were evaluated for their in vitro antibacterial activity against staphylococcus aure ... | 2013 | 23942420 |
| fortuitous vasculitis. | a 43-year-old man with a cardiac device for dilated cardiomyopathy presented with fever, night sweats, and weight loss. investigations revealed pancytopenia, acute renal failure, abnormal lung function, and raised inflammatory markers. a renal biopsy demonstrated pauci-immune necrotizing crescentic glomerulonephritis. he was diagnosed with pulmonary-renal antineutrophil cytoplasmic antibody-negative systemic small vessel vasculitis. he commenced immunosuppression with prednisolone and cyclophosp ... | 2012 | 22250755 |
| microbial pathogens in source and treated waters from drinking water treatment plants in the united states and implications for human health. | an occurrence survey was conducted on selected pathogens in source and treated drinking water collected from 25 drinking water treatment plants (dwtps) in the united states. water samples were analyzed for the protozoa giardia and cryptosporidium (epa method 1623); the fungi aspergillus fumigatus, aspergillus niger and aspergillus terreus (quantitative pcr [qpcr]); and the bacteria legionella pneumophila (qpcr), mycobacterium avium, m. avium subspecies paratuberculosis, and mycobacterium intrace ... | 2016 | 27260619 |
| mixed infection of an atypical mycobacterium and aspergillus following a cryopreserved fat graft to a face. | we report a chronic infection of a patient who received a cryopreserved fat graft on her face. a 22-year-old female patient presented with multiple abscesses of her face. four months previously, she received a second fat graft with the fat harvested at a previous surgery which was cryopreserved for 2 months. on examination, she had tender erythematous nodules on both cheeks. a computed tomography of her neck showed multiple peripheral enhancing nodular lesions. in an open pus fungus culture, asp ... | 2013 | 24036751 |
| commercial disinfectants during disinfection process validation: more failures than success. | disinfection process validation is mandatory before introduction of a new disinfectant in hospital services. commercial disinfection brands often question existing hospital policy claiming greater efficacy and lack of toxicity of their products. inadvertent inadequate disinfection leads to morbidity, patient's economic burden, and the risk of mortality. | 2016 | 27656441 |
| [atypical agents of wound infection and targeted samples]. | all open wounds are primarily contaminated and subsequently colonized by microorganisms, predominantly bacteria. only about 30% of chronic wounds are also infected. factors which favor the development of infection are the following: large quantity of bacteria, presence of virulence factors, their quantity and number, predominantly the synergy of aerobic and anaerobic bacteria, and formation of biofilm. common agents of infection of acute and chronic wounds are staphylococcus aureus, mrsa, strept ... | 2012 | 23193825 |
| phytochemical and antimicrobial investigations of stilbenoids and flavonoids isolated from three species of combretaceae. | the antimicrobial activity and chemistry of the african combretaceae has been well studied in recent years. the present study aimed to investigate the phytochemistry and antimicrobial activity of lesser known members of this family viz. c. hereroense, c. apiculatum and c. collinum. pulverized leaves of c. collinum and c. apiculatum, and the fruit of c. hereroense were extracted with organic solvents and subjected to preparative chromatography. seventeen phenolic constituents including four phena ... | 2012 | 22546149 |
| synthesis of novel isothiazolopyridines and their in vitro evaluation against mycobacterium and propionibacterium acnes. | in this paper we describe synthesis, structures and some physicochemical properties of 20 isothiazolopyridines 8-13 substituted differently into an isothiazole ring as well as their in vitro antibacterial assays against mycobacterium tuberculosis h37rv, mycobacterium fortuitum pcm 672 and propionibacterium acnes pcm 2400. compound 13a was found to be the most active derivative against m. tuberculosis h37rv, demonstrating 100% growth inhibition of microorganisms in the primary screen (minimum inh ... | 2013 | 23850103 |
| antibacterial activity and cytotoxicity analysis of halistanol trisulphate from marine sponge petromica citrina. | an aqueous extract and fraction from the marine sponge petromica citrina have antibacterial activity. we performed a chemical and biological characterization of the antibiotic substance from p. citrina and investigated its mode of action on staphylococcus aureus cells. | 2012 | 22729926 |
| microbiological quality and occurrence of nontuberculous mycobacteria in fresh-squeezed orange juice samples purchased from street vendors in mexico city. | nontuberculous mycobacteria (ntm) are potentially pathogenic agents commonly found in a natural ecosystem. for this reason, food is considered another source of ntm transmission for humans. the aims of this study were to evaluate the microbiological quality and the occurrence of ntm in fresh-squeezed orange juice samples purchased from street vendors. all 102 samples analyzed were positive for aerobic mesophilic bacteria (amb), with limits ranging from 1.8 to 6.2 log cfu/ml. a total of 55 (54%), ... | 2016 | 28221956 |
| noncanonical smc protein in mycobacterium smegmatis restricts maintenance of mycobacterium fortuitum plasmids. | research on tuberculosis and leprosy was revolutionized by the development of a plasmid transformation system in the fast-growing surrogate, mycobacterium smegmatis. this transformation system was made possible by the successful isolation of a m. smegmatis mutant strain mc(2)155, whose efficient plasmid transformation (ept) phenotype supported the replication of mycobacterium fortuitum pal5000 plasmids. in this report, we identified the eptc gene, the loss of which confers the ept phenotype. ept ... | 2014 | 25197070 |
| efficacy of decontamination and sterilization of a single-use single-incision laparoscopic surgery port. | to determine the efficacy of decontamination and sterilization of a disposable port intended for use during single-incision laparoscopy. | 2013 | 23718663 |
| molecular identification of mycobacterium species of public health importance in cattle in zimbabwe by 16s rrna gene sequencing. | mycobacterium species are naturally found in the environment as well as in domestic animals such as cattle. so far, more than 150 species of mycobacterium, some of which are pathogenic, have been identified. laboratory isolation, detection and identification of mycobacterium species are therefore critical if human and animal infections are to be controlled. the objective of this study was to identify mycobacterium species isolated in cattle in zimbabwe using 16s ribosomal rna gene amplification ... | 2015 | 26668660 |