| [cariogenicity of propionibacterium acnes, streptococcus intermedius and streptococcus mutans in germ-free rats]. | a comparative study has been made on the cariogenic potentials of propionibacterium acnes atcc 11828, streptococcus intermedius oe-1 and streptococcus mutans oz-1. the strains of p. acnes and s. intermedius have chondroitinase activity. as metabolic end-products, the p. acnes strain produces mainly a weak acid, propionic acid, whereas strong lactic acid is the main product of the strains of s. intermedius and s. mutans. five germ-free rats were used for infection with each bacterial strain. the ... | 1989 | 2637631 |
| protection of mice against vaccinia and herpes simplex virus infection by propionibacterium acnes. | heat-killed cell suspension of several propionibacterium acnes strains were prepared and studied for their protective activity in viral infection of mice and immunomodulating properties. majority of the strains caused marked spleen enlargement in the treated mice. these changes persisted for several weeks. only some of the tested strains enhanced significantly primary humoral immune response against sheep red blood cells. there was no increase, however, in neutralizing or hemagglutination-inhibi ... | 1989 | 2639640 |
| propionibacterium acnes immunotherapy in chronic recurrent canine pyoderma. an adjunct to antibiotic therapy. | in a randomized, double-blind, placebo-controlled study, dogs with chronic recurrent pyoderma were treated with antibiotics plus intravenous injections of either propionibacterium acnes or placebo. responses (an increase, decrease, or clearing of lesions) were measured and evaluated statistically. eighty percent (12 of 15) of the dogs treated with antibiotics and p acnes compared with 38% (five of 13) of the dogs treated with antibiotics and placebo responded with significant improvement or comp ... | 1989 | 2647969 |
| regulation of insulin and interleukin-1 release after propionibacterium acnes-induced macrophage activation in mice. | the administration of a potent activator of macrophages (m phi), propionibacterium acnes, in nondiabetic mice was associated with the release of significant amounts of interleukin-1 (il-1) in the peritoneal cavity and plasma within 4 hours after treatment. shortly before il-1 peaks were observed, the levels of pancreatic insulin, [3h]leucine-proinsulin, and insulin/total protein ratio were elevated, and followed by a transient but marked hyperinsulinemia at 4 hours after treatment. a single dose ... | 1989 | 2648066 |
| soluble malarial antigens are toxic and induce the production of tumour necrosis factor in vivo. | heat-stable soluble products of rodent malarial parasites induce activated peritoneal macrophages to secrete tumour necrosis factor (tnf) in vitro. since heat-stable parasite antigens are known to be present in the circulation of patients with malaria and it has been suggested that much of the pathology of malaria is due to tnf, we investigated the ability of such antigens to induce the production of tnf in vivo and to be toxic to mice. injection of antigens obtained from plasmodium yoelii or fr ... | 1989 | 2654012 |
| propionibacterium acnes in sarcoidosis. | | 1989 | 2657925 |
| intravascular coagulation in the development of massive hepatic necrosis induced by corynebacterium parvum and endotoxin in rats. | when escherichia coli endotoxin was intravenously injected into rats given killed corynebacterium parvum 6 days previously, fibrin deposition and endothelial cell injury occurred in hepatic sinusoids at 1.5 h and were intensified thereafter. serum alanine aminotransferase values were increased along with prothrombin time and decreased plasma levels of antithrombin iii and coagulation factor viii:c at 5 h. antithrombin iii concentrate (plus heparin) or superoxide dismutase infused concurrently wi ... | 1989 | 2660248 |
| characterization of a new spontaneously developed murine mammary adenocarcinoma in syngeneic balb/c hosts. | a mouse mammary tumor cell line, designated jc, has been established from a spontaneously developed primary adenocarcinoma of an aged virgin female balb/c mouse. isoenzyme analyses including glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and peptidase proved that this cell line is of murine origin and devoid of contamination from other species. karyotyping revealed that the number of chromosome ranged from 26 to 100, with a modal number of 40. electron microscopic examination detected ... | 1989 | 2666384 |
| propionibacterium acnes causes postoperative brain abscesses unassociated with foreign bodies: case reports. | propionibacterium acnes was isolated in pure culture from brain abscesses that occurred in two patients after intracranial surgery. although such infections are usually associated with cerebrospinal fluid shunts and other foreign bodies, these cases clearly demonstrate the pathogenicity of this anaerobic diphtheroid in the absence of such. progression of p. acnes infection in the central nervous system can be insidious. to treat such infections adequately, therapy cannot rely upon some standard ... | 1989 | 2666880 |
| [bacterial skin flora, host defense and skin infections]. | resident skin flora consists of coagulase-negative staphylococci, micrococci, aerobic and anaerobic coryneform organisms (i.e. propionibacterium acnes) as well as gram-negative rods (i.e. acinetobacter). their growth is favoured by increased temperature and humidity and modified by body location, age, sex and chronic diseases (i.e. diabetes mellitus). occupation, hospitalization, soaps and disinfectants as well as medications exert promoting and inhibiting influences, too. in addition, environme ... | 1989 | 2693140 |
| suppression of resistance to salmonella typhimurium in young chickens inoculated with corynebacterium parvum. | the effect of corynebacterium parvum on resistance to salmonella typhimurium infection was evaluated in young chickens. one-day-old chickens were inoculated subcutaneously (sc) or intraperitoneally (ip) with 1.4 mg killed c. parvum and challenged by ip injection with 5.0 x 10(7) s. typhimurium 4 days later. spleen and bursa of fabricius weights were not altered in the c. parvum-inoculated chickens. a transient increase in thymus weight occurred 3 days after inoculation with c. parvum. phytohemag ... | 1989 | 2695051 |
| role of respiratory-burst products from polymorphonuclear leukocytes in the antitumor activity of propionibacterium acnes vaccine. | tumor cells injected into balb/c mice together with heat-killed 48-h p. acnes cells were rendered nontumorigenic as early as 12 h after injection, as determined by the inability of the tumor cells to give rise to tumors when transferred to a new host. determination of tumor cell antigen levels by elisa indicated that the tumour antigens had virtually disappeared by 24 h after injection of tumor cells and p. acnes. in contrast, in control animals injected with tumor cells only, there was an initi ... | 1989 | 2706641 |
| [sepsis due to propionibacterium acnes?]. | | 1989 | 2707126 |
| effects of bile acids on liver cell injury by cultured supernatant of activated liver adherents cells. | when heat-killed propionibacterium acnes (p. acnes) is intravenously injected into mice followed by an intravenous injection of a small amount of lipopolysaccharide (lps) 7 days later, most of the mice die of massive hepatic cell necrosis within 24 hours of lps injection. in addition, when the liver adherent cells including kupffer cells are separated from the mice 7 days after p. acnes injection and incubated in vitro with lps, remarkable activity of the cytotoxic factor is found in the culture ... | 1989 | 2707549 |
| activation of murine peritoneal macrophages by saikosaponin a, saikosaponin d and saikogenin d. | macrophage activation by saikosaponins and saikogenins was investigated and compared with that by other saponins and macrophage stimulants. saikosaponins a and d induced a marked cell accumulation in the peritoneal cavity when administered intraperitoneally. among saikosaponins and saikogenins tested, saikosaponin d significantly activated peritoneal macrophages in terms of enhancement of phagocytic activity, increased level of cellular lysosomal enzyme (acid phosphatase), induction of cytostati ... | 1989 | 2707937 |
| automated analysis of 2,3-diamino-2,3-dideoxy-d-glucuronic acid by cation exchange chromatography with fluorometric postcolumn derivatization. | 2,3-diamino-2,3-dideoxy-d-glucuronic acid (diaminoglucuronic acid) occurs as its di-n-acetyl derivative as a unique constituent of some bacterial cell walls. a sensitive chromatographic method for its determination is described. diaminoglucuronic acid was well separated from glucosamine and galactosamine in about 80 min on a dionex dc-6a cation exchange column (0.9 x 18 cm, 50 degrees c) with a sodium citrate buffer (ph 5.28) containing boric acid (0.2 m). the amino sugars in the eluate were mon ... | 1989 | 2712291 |
| hyperthermia induced polyphosphate changes in propionibacterium acnes as studied by 31p nmr. | the polyphosphate component in 31p nmr spectra of the gram-positive propionibacterium acnes increased after hyperthermia treatment. the cells were exposed to temperatures in the interval from 15 degrees c to 45 degrees c. the amount of polyphosphate increased with increasing temperature. there were no temperature induced changes in the other phosphorous components seen in the spectra with exception of a decrease in atp for higher temperatures. the increase in polyphosphates was less than that ob ... | 1989 | 2712997 |
| role of novel adjuvants in specific active immunotherapy. | | 1989 | 2717639 |
| role of lipids in augmenting the antibacterial activity of benzoyl peroxide against propionibacterium acnes. | antimicrobial activity and physicochemical properties of benzoyl peroxide (bp) were investigated to determine the mechanism of action for the compound as an antiacne agent. the mics and mbcs against nine strains of propionibacterium acnes ranged between 100 and 800 micrograms/ml in a nutrient broth system, with a median fourfold increase in activity demonstrated when lipid was added. the partition coefficient of bp in a 50:50 artificial skin lipid and water system was greater than 2,500, with th ... | 1989 | 2729927 |
| augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow. | a variety of biologic response modifiers (brm) can potently augment nk activity in nonlymphoid organs. by using the liver as a model organ, we have shown that this augmentation of organ-associated nk activity is coincident with a 10- to 15-fold increase in the number of large granular lymphocytes (lgl) which can be isolated. the present study was designed to investigate the mechanism by which brm induce this increase in liver-associated lgl and the coincident increase in hepatic nk activity. ini ... | 1989 | 2732472 |
| lymphocytes generated by in vivo priming and in vitro sensitization demonstrate therapeutic efficacy against a murine tumor that lacks apparent immunogenicity. | the adoptive transfer of sensitized lymphocytes is an effective means to mediate the regression of established tumors. however, successful therapy can only be demonstrated in animal models where tumors are intrinsically immunogenic, capable of eliciting systemic immunity. to explore the potential of this therapeutic approach to tumors of less immunogenicity, we have selected and used a murine tumor, mca 102, for the current study because all attempts to immunize syngeneic mice failed. we report ... | 1989 | 2738408 |
| focal infections of the central nervous system due to propionibacterium acnes. | propionibacterium acnes as the single cause of intracranial infections has rarely been described. we present four patients in whom the infection arose as a result of a breach of skin tegument, and postulate that p. acnes is an under-recognised pathogen. | 1989 | 2745987 |
| chemiluminescence in a macrophage cell line modulated by biological response modifiers. | we have studied a murine macrophage cell line, j774, and found these cells capable of a zymosan-triggered chemiluminescent oxidative burst. such activity was enhanced by preincubation with corynebacterium parvum (cp), bacillus calmette-guerin, and lipopolysaccharide (lps). under similar conditions, cp and lps were shown to enhance j774-mediated tumor cell lysis. we have also demonstrated that murine interferon alpha + beta rendered j774 cells more sensitive to the actions of cp and lps. these re ... | 1989 | 2746137 |
| [antibody activity to propionibacterium acnes in bronchoalveolar lavage fluid in sarcoidosis]. | while increased levels of circulating antibody to various microorganisms have been reported in sarcoidosis patients, the pathogenesis of the disease is still unknown. in this report, the levels of antibody activities against propionibacterium acnes (p. acnes) were measured in bronchoalveolar lavage fluid (balf) in patients with sarcoidosis, using an enzyme-linked immunosorbent assay method. each immunoglobulin class of antibody activity to p. acnes was corrected by albumin concentrations in balf ... | 1989 | 2747059 |
| serotonin and tryptamine metabolism in the acute hepatic failure model: changes in tryptophan and its metabolites in the liver, brain and kidney. | when heat-killed propionibacterium acnes, a gram-positive anaerobe, is intravenously injected into mice followed by an intravenous injection of gram-negative lipopolysaccharide (lps) 7 days later, most of the mice die of massive hepatic cell necrosis within 24 hours of lps injection. using this experimental model, acute hepatic failure was induced in mice, and the tryptophan metabolism in the liver, brain and kidney was studied. as a result, the tryptophan level was remarkably high in all three ... | 1989 | 2748146 |
| non-specific resistance to babesia divergens in the mongolian gerbil (meriones unguiculatus). | inoculation of mature gerbils with bcg gave protection to subsequent infection with b. divergens when inoculated by the intracardiac and intraperitoneal routes, the latter showing a dose dependent relationship. bcg vaccination was most effective in immature gerbils (less than 4 weeks old), which are innately resistant to b. divergens. vaccination of gerbils with killed propionesbacterium acne and zymosan a failed to elicit a protective response, which contrasts conspicuously with rodent babesia ... | 1989 | 2759766 |
| [changes in production of platelet activating factor by adherent hepatocytes of mice with experimental liver failure]. | it is thought that the platelet activating factor (paf) enhances the immune response and inflammatory reaction. we studied the production of paf from liver adherent cells. as a result, liver adherent cells produced paf, when they were stimulated with calcium ionophore. in addition, when mice were treated with heat-killed propionibacterium acnes and the mononuclear cells were infiltrated into the liver, a significantly larger amount of paf was produced compared to normal mice. | 1989 | 2770018 |
| diphtheroids as ocular pathogens. | unlike corynebacterium diphtheriae and propionibacterium acnes, the pleomorphic gram-positive rods known as diphtheroids are generally regarded as nonpathogenic contaminants of the human external eye. we reviewed five years of microbiology records at wills eye hospital and studied a series of eight cases of apparently infectious keratitis associated with heavy growth of diphtheroids on cultures of ulcer scrapings. all of these cases included indolent ulcers that occurred almost exclusively in el ... | 1989 | 2774033 |
| hematologic interactions of endotoxin, tumor necrosis factor alpha (tnf alpha), interleukin 1, and adrenal hormones and the hematologic effects of tnf alpha in corynebacterium parvum-primed rats. | endotoxin reduces the release among other cytokines of tumor necrosis factor (tnf) and interleukin 1 (il-1) and causes peripheral lymphopenia and a dose-response-dependent initial neutropenia followed by a monophasic neutrophilia. tnf alone induces lymphopenia and an initial neutropenia followed by a biphasic neutrophilia. il-1 alone induces lymphopenia and a monophasic neutrophilia. tnf-plus-il-1 caused a greater lymphopenia than either monokine alone, suggesting that both monokines contribute ... | 1989 | 2786048 |
| analysis of the proinflammatory property of epidermal cyst contents: chemotactic c5a anaphylatoxin generation. | we investigated in vitro the contents of epidermal cysts for complement activation and found that they activated complement mainly through the alternative pathway. chemotactic c5a anaphylatoxin produced by the cyst contents after contact with serum most likely plays a significant role in the initiation and aggravation of inflammation in ruptured epidermal cysts. our additional study disclosed that components of three representative follicular resident microorganisms (pityrosporum ovale, propioni ... | 1989 | 2786384 |
| [interleukin-2 production and receptor expression of alveolar lymphocytes stimulated by propionibacterium acnes in sarcoidosis]. | we previously reported that alveolar lymphocytes in patients with active sarcoidosis are sensitized to propionibacterium acnes (p. acnes) which may play a significant role in the induction of alveolitis in these patients. however, the mechanism of lymphocyte activation is not fully understood. in this study, we further investigated the production of interleukin-2 (il-2), and the responsiveness to il-2 of alveolar lymphocytes obtained from sarcoidosis patients and stimulated by p. acnes in vitro. ... | 1989 | 2787441 |
| [infections by anaerobes in children: frequency of isolation and antimicrobial resistance]. | we studied the frequency of isolation and antimicrobial susceptibility of strict anaerobic bacteria isolated in a paediatric hospital. a total of 1,753 samples from purulent material and hemocultures were processed. one hundred and thirty strains were isolated from 95 children: 44 from 48 cases of peritonitis (91.7%), 2 from 8 brain abscesses (25%), 23 from 124 soft tissue abscesses (18.5%), 4 from 64 empyemas or lung abscesses (6.3%) and 22 from 1,509 hemocultures (1.5%). mixed infection (anaer ... | 1989 | 2788434 |
| management options for propionibacterium acnes endophthalmitis. | the authors reviewed the management of nine culture-proven cases of propionibacterium acnes endophthalmitis which presented at an average of 4 months after extracapsular cataract extraction (ecce) and posterior chamber intraocular lens (pc iol) implantation. the initial signs included a white intracapsular plaque (9/9), vitritis (9/9), granulomatous uveitis (4/9), nongranulomatous uveitis (5/9), hypopyon (4/9), beaded fibrin strands in the anterior chamber (3/9), and diffuse intraretinal hemorrh ... | 1989 | 2788852 |
| [comparison of the effectiveness and adverse effects of a corynebacterium parvum vaccine made in czechoslovakia with coparvax, a british preparation made by wellcome, in the treatment of malignant pleural effusions]. | malignant pleural effusion complicates various malignant diseases, most frequently lung and breast cancer. a group of 20 patients with this complication were treated with the czechoslovak vaccine corynebacterium parvum and the english preparation coparvax, and their effects and side-effects were compared. within 4 weeks following the application, 7 patients died. in 9 surviving patients, the exudate ceased to be replenished and in 4 persons, after intrapleural application of the preparation, it ... | 1989 | 2790915 |
| toxicity of il-2 and corynebacterium parvum following direct intracranial injection. | the toxicity of il-2 and/or c. parvum when injected directly into the mouse brain was examined by survival and histopathology using different numbers of injections, different doses of il-2, different solvents for the il-2, and different doses and routes of administration of c. parvum. two injections was found significantly to increase mortality (19%) over a single injection (4%). mortality from two injections of 30,000 u (23%) or 60,000 u (20%) was higher than from two injections of 15,000 u (12 ... | 1989 | 2795120 |
| intralenticular abscess. | intralenticular abscess is an uncommon complication of surgery or trauma. a case of intralenticular abscess following penetrating trauma is presented. in this case, the offending organism was identified as propionibacterium acnes. this organism is considered to be a cause of slowly progressing endophthalmitis and has been implicated as a cause of the so-called toxic lens syndrome. | 1989 | 2803777 |
| propionibacterium acnes isolated from explanted intraocular lens in pseudophakic bullous keratopathy. | propionibacterium acnes is an anaerobic bacterium that has been reported to produce ocular infection or inflammation following surgery or penetrating trauma. it has been well documented as an etiologic agent associated with infections of prosthetic implants, including intraocular lenses (iols). p. acnes is part of the natural flora of the external eye and has biological properties that may promote, heighten, or prolong an inflammatory response. it not only resists in vitro degradation by reticul ... | 1989 | 2805713 |
| an experimentally-induced acute hepatic failure model in various strains of mice. | when balb/cajc1 mice are intravenously injected with heat-killed propionibacterium acnes (p. acnes) followed by an intravenous injection of lipopolysaccharide (lps) 7 days later, massive necrosis is induced in the liver tissue and most of the mice die within 24 hours of lps injection. using this experimental model, acute hepatic failure was induced in various strains of mice and the difference in the response was studied. as a result, as in balb/cajc1 mice, acute hepatic failure was also induced ... | 1989 | 2806831 |
| [the response of alveolar lymphocytes induced by propionibacterium acnes in pulmonary sarcoidosis: correlation with clinical studies, pulmonary function studies and bronchoalveolar lavage]. | current concepts of the pathogenesis of sarcoidosis suggest that the alveolitis in this disorder is related to increased numbers of helper t-cells within the lungs. however, the mechanism of this accumulation of lymphocytes is not known. we have reported that proliferation of alveolar lymphocytes induced by p. acnes is increased in patients with active sarcoidosis. to determine whether the response of alveolar lymphocytes would be useful in staging the activity of pulmonary sarcoidosis, we studi ... | 1989 | 2810973 |
| [spondylitis of the cervical spine caused by non-sporogenic anaerobes]. | | 1989 | 2811118 |
| infectious arthritis caused by propionibacterium acnes: a report of two cases. | propionibacterium acnes, a micro-organism with low pathogenicity, rarely causes arthritis in a joint without a prosthesis. this report deals with two cases of p acnes infectious arthritis probably caused by direct penetration of the micro-organism into the joint space during arthrocentesis, despite the use of strict disinfection procedures. p acnes isolated from synovial fluid cannot be dismissed as a bothersome contaminant without due consideration of the clinical status of the individual patie ... | 1989 | 2818021 |
| two-dimensional gel electrophoresis of ribosomal proteins from propionibacterium acnes and granulosum. | ribosomal proteins (r-proteins) from a type i strain (atcc 11827) and a type ii strain (atcc 11828) of propionibacterium acnes (p. acnes) and from a propionibacterium granulosum (p. granulosum) strain (atcc 11829-2) were analyzed using two-dimensional polyacrylamide gel electrophoresis (two-dimensional page), for the purpose of genetical analysis of the p. acnes type i and type ii strains and the p. granulosum strain. among the fifty r-proteins in all, almost all of the proteins were electrophor ... | 1989 | 2818796 |
| bone marrow derived macrophages have polyamine and ectoenzyme phenotypes distinct from resident macrophages. | several prototype macrophage (mo) populations were compared for differences in ectoenzyme phenotype and polyamine content. resident peritoneal mo and corynebacterium parvum (cp)-activated peritoneal mo expressed unique ectoenzyme phenotypes, while bone marrow derived mo (bmdmo), obtained from stem cells after 7 days in culture with colony stimulating factor, and thioglycollate (tg)-elicited peritoneal mo exhibited a similar ectoenzyme phenotype. all of the mo populations, however, differed in po ... | 1988 | 2835568 |
| effect of macrophage activation on resistance of mouse peritoneal macrophages to infection with herpes simplex virus types 1 and 2. | to define the effect of heterogeneity of murine peritoneal macrophages (m phi) on intrinsic resistance to herpes simplex virus (hsv) infection, several m phi populations were characterized for their response to infection with hsv type 1 (hsv-1) and hsv-2. steady-state resident m phi (res m phi) were compared in parallel with m phi activated with corynebacterium parvum (now designated propionibacterium acnes) (cp m phi) and thioglycollate-elicited inflammatory m phi (tg m phi). res m phi were com ... | 1988 | 2841412 |
| effect of endotoxin on release of reactive oxygen intermediates by rat hepatic macrophages. | reactive oxygen intermediates released by activated hepatic macrophages have been implicated in the pathogenesis of a rat model of liver injury induced by sequential administration of corynebacterium parvum and endotoxin. in this model, c. parvum causes extensive infiltration of the liver with activated macrophages, but severe liver injury occurs only after subsequent exposure to endotoxin. we have therefore investigated the effects of endotoxin on the release of reactive oxygen intermediates by ... | 1988 | 2846404 |
| influence of immunomodulatory agents on bovine humoral and cellular immune responses to parenteral inoculation with bovine rotavirus vaccines. | sodium diethyldithiocarbamate (dtc), mycobacterium cell wall extract (mcwe, regressin), killed corynebacterium parvum (c. parvum, immunoregulin) and muramyldipeptide (mdp) were each combined with purified, live bovine rotavirus and inoculated into 3 month-old holstein-friesian calves in order to examine their ability to potentiate specific humoral and cellular immune responses. the vaccinated calves were boosted twice at 3 and 6 weeks after initial vaccine inoculation. the rotavirus was administ ... | 1988 | 2847397 |
| bacterial products as immunomodulating agents. | | 1985 | 2858453 |
| adverse effect of intrapleural corynebacterium parvum as adjuvant therapy in resected stage i and ii non-small cell carcinoma of the lung. ludwig lung cancer study group. | intrapleural corynebacterium parvum 7 mg or placebo was administered postoperatively as adjuvant therapy to patients with resected stage i and ii non-small cell lung cancer in a prospective, randomized, multicenter trial. a total of 475 patients were entered into this study between july, 1977, and february, 1979. of this group, 405 can be evaluated, with an average follow-up time of 4.6 years. more side effects, especially fever and chest pain, were observed in patients receiving corynebacterium ... | 1985 | 2860271 |
| the involvement of dendritic cells in the handling of the immune stimulant c. parvum. a morphological investigation using immunoperoxidase techniques. | in earlier experiments we showed that locally administered corynebacterium parvum (c. parvum) stimulated the t-cell system and had a beneficial effect on the recurrence rate of surgically resected cancers of the uterine cervix. in this paper we report the use of an immunoperoxidase technique to trace c. parvum antigen in the draining lymph nodes. in a guinea pig model the popliteal lymph node was studied after the injection of 70 micrograms of c. parvum in the hind footpad. at 6 h, intact bacter ... | 1985 | 2861687 |
| comparative in-vitro activity of sch 34343 and other antimicrobial agents against anaerobic bacteria. | the activity of sch 34343 was determined against 575 strains of anaerobic bacteria by an agar-dilution method. its activity was compared with that of benzylpenicillin, piperacillin, cefoxitin, imipenem, clindamycin, metronidazole, chloramphenicol, vancomycin, fusidic acid and bacitracin. sch 34343 and imipenem were the most active agents tested. based on these results, sch 34343 appears to be a promising antimicrobial agent for anaerobic infections and warrants further clinical investigations. | 1985 | 2863246 |
| intrapleural and intravenous corynebacterium parvum in patients with resected stage i and ii non-small cell carcinoma of the lung. the ludwig lung cancer study group. | a prospective randomized trial compared the administration of intrapleural plus intravenous corynebacterium parvum (c. parvum) versus placebo in patients with resected stage i and stage ii non-small cell bronchogenic carcinoma. treatment consisted of 7 mg c. parvum injected into the pleural space and 7 mg c. parvum intravenously once between days 6 and 12 postoperatively and 7 mg intravenously every 3rd month during the 1st year. intrapleural administration of 35 cc of saline served as the place ... | 1986 | 2876772 |
| protection of mice against intestinal amoebiasis with bcg, corynebacterium parvum and listeria monocytogenes. | treatment with corynebacterium parvum or bcg, or infection with live listeria monocytogenes was found to protect mice against subsequent infection with entamoeba histolytica. complete protection was obtained in mice treated with 10(7) (colony forming units) of bcg but not with 10(5). partial protection was achieved with 10(6) of bcg. these data provide evidence that non-specific immunity plays an important role in the host defense against amoebic infection. | 1986 | 2880331 |
| mechanism of decline of natural killer cell activity in corynebacterium parvum-treated mice: inhibition by erythroblasts and thy 1.2+ lymphocytes. | injection of (c57bl/6 x dba/2)f1 mice with corynebacterium parvum (cp), iv, resulted in a depression of splenic natural killer (nk) cell activity 7-17 days after treatment. this decline in reactivity was accompanied by an increase in splenic tumor-binding cells and a decrease in cytotoxic tumor-binding cells as evaluated in a single-cell assay. morphologic analysis indicated that the increased tumor-binding cells following cp injection were due to erythroblasts binding to yac-1 tumor cells. with ... | 1987 | 2887687 |
| ischaemic mouse thigh model for evaluation of pathogenicity of non-clostridial anaerobes. | a mouse thigh model has been devised in which the growing culture of non-clostridial anaerobe in the ischaemic tissue produces inflammatory swelling and death. the swelling of the right thigh served as an index of pathogenicity of the test strain in comparison to the negatively reacting left thigh which received injection of the control strain of bifidobacterium infantis. actinomyces naeslundii exceptionally caused death in all animals within 24 h. mortality and thigh swelling were pronounced (g ... | 1989 | 2914729 |
| modulation of hematoporphyrin derivative-sensitized phototherapy with corynebacterium parvum in murine transitional cell carcinoma. | the interaction of photodynamic therapy (pdt) with hematoporphyrin derivative (hpd) and immunotherapy with corynebacterium parvum (cp) was studied in a murine transitional cell carcinoma (mbt-2) model. c3h/he mice were transplanted subcutaneously in the hind limb with 2.5 x 10(5) tumor cells. one day after transplantation, mice were randomized into groups to receive saline (control), pdt, cp 25 micrograms, cp 250 micrograms, cp 25 micrograms + pdt, and cp 250 micrograms + pdt. pdt was administer ... | 1989 | 2919485 |
| peptostreptococcus magnus does not cause hematogenous infections in experimental arthroplasties. | rabbits with cemented endoprostheses in the knee joints were given 1-ml intravenous injections of suspensions containing peptostreptococcus magnus (3 x 10(8) colony-forming units/ml) on three consecutive days seven weeks postoperatively. the animals were killed after another seven weeks. the bacterial challenge did not result in infection. this is in contrast to a previous study using the same experimental system with another anaerobic bacterial species, propionibacterium acnes, which caused inf ... | 1989 | 2924473 |
| endophthalmitis due to propionibacterium acnes sequestered between iol optic and posterior capsule. | a 68-year-old woman had delayed onset, persistent uveitis following routine extracapsular cataract extraction with posterior chamber intraocular lens implantation. the patient initially responded to topical steroids, but developed a whitish capsular plaque through to represent possible propionibacterium acnes endophthalmitis. a vitrectomy and capsular biopsy yielded cultures positive for p. acnes only after nine days. the intraocular lens was left in place. light and electron microscopy revealed ... | 1989 | 2927902 |
| characteristics of toxic shock syndrome toxin 1-induced lectin-like activity and inhibitor(s) in rabbit serum. | in adult rabbits intravenously injected with toxic shock syndrome toxin 1 (tsst-1) or staphylococcal enterotoxin b, serum lectin-like activity (detectable by cation-dependent agglutination of bacteria) developed. this activity was sensitive to heat, trypsin, and formaldehyde but resistant to neuraminidase or galactose oxidase. formaldehyde-fixed propionibacterium acnes or escherichia coli cells reactive with plant lectins provided sensitive targets for titration of serum agglutination activity t ... | 1989 | 2928648 |
| reverse effect of gram-positive bacteria vs. gram-negative bacteria on adjuvant-induced arthritis in germfree rats. | germfree (gf) f344 rats developed severe adjuvant-induced arthritis with a 100% incidence after a single intradermal injection of heat-killed mycobacterium bovis (bcg). specific pathogene-free (spf) rats developed less severe arthritis with a lower incidence. the rats colonized with escherichia coli or bacteroides developed mild disease comparable to that in spf rats. the rats colonized with bifidobacterium, propionibacterium acnes, lactobacillus casei, l. fermentum, l. murini, and l. acidophilu ... | 1985 | 2931580 |
| acne vulgaris. treatments and their rationale. | | 1985 | 2932686 |
| the effect of bone marrow depletion on prostaglandin e-producing suppressor macrophages in mouse spleen. | the i.p. injection of corynebacterium parvum (cp) into cba/j mice effected increases in macrophage colony-forming cells (m-cfc) when spleen cells were cultured with l cell culture filtrate as a source of colony-stimulating factor. significant increases in phagocytic macrophages (m phi) with fc receptors for igg2a and igg2b immune complexes were additionally noted among the spleen cells in these mice. these m phi effectively inhibited con a-induced lymphocyte proliferation, probably reflecting a ... | 1985 | 2933455 |
| suppression of murine nk activity induced by corynebacterium parvum: further characterization and abrogation of suppressor cells. | formalin-killed corynebacterium parvum (cp), given at a dose of 0.4-0.7 mg/mouse iv or ip, induced suppressor cells for nk activity in b6c3f1 mice. the suppressor cells belong to at least two different populations, plastic adherent and nonadherent, and were not depleted by antibodies specific for thy-1.2, iak, or nk-1.2 surface markers. administration of p-i:c, an interferon-inducer, to animals 18 h before the assay did not affect the suppressor activity. hypotonic shock treatment of splenocytes ... | 1986 | 2935247 |
| suppression and abrogation of suppression of induced nonspecific cytotoxicity against tumor cells. | fresh spleen cells obtained from normal mice of various strains including athymic mice and nk-less beige mice were found to suppress in a h-2-nonrestricted manner nonspecific cytotoxic activity of in vitro-cultured normal mouse spleen cells or that of nonadherent peritoneal exudate cells from mice treated with propionibacterium acnes. natural killer-insensitive mm2 ascites tumor cells were used as the target of assay of the cytotoxicity. the suppressive activity of fresh spleen cells was not aff ... | 1985 | 2935654 |
| tumor-specific suppressor t-cells which inhibit the in vitro generation of cytolytic t-cells from immune and early tumor-bearing host spleens. | spleen cells from dba/2 mice, after immunization with syngeneic p815 mastocytoma cells and corynebacterium parvum, respond to p815 in vitro with a brisk, secondary-type generation of cytotoxic cells. this cytotoxicity is mediated by antigen-specific t-lymphocytes and correlates with resistance to in vivo challenge. this model confirms the observations of previous investigators made in semisyngeneic hosts using an in vivo transfer model. spleen cells from "early" tumor-bearing hosts (tbhs), 7-12 ... | 1986 | 2936451 |
| [proof of the effectiveness of a clotrimazole cream paste in acne vulgaris]. | the efficacy of clotrimazol cream paste containing a penetration enhancer in the treatment of acne vulgaris was objectified by investigating the sebum composition. following treatment over three and six weeks, the ratio of triglyceride to free fatty acid significantly increased, which indicated an effective reduction of the lipase activity of propionibacterium acnes within the sebaceous follicle. | 1986 | 2938349 |
| acne vulgaris. the past. the present and the future. | | 1985 | 2939675 |
| splenocytes from tumor-bearing corynebacterium parvum treated mice maintain interleukin-2 and -3 activity. | systemic and local administration of the bacterium corynebacterium parvum (more accurately known as propionibacterium acnes) is reported to exert antitumor action via activated macrophages or short-lived cytotoxic t lymphocytes (ctl), respectively. this study examined the effect of c. parvum treatment on resulting in vitro interleukin levels, which are components in the sequence of events leading to the development of effective ctl. c. parvum administration prevented palpable fibrosarcoma develo ... | 1986 | 2939948 |
| reaction of the thymus and the bursa of fabricius in chickens inoculated with corynebacterium parvum. | | 1985 | 2940837 |
| acne vulgaris in childhood. pathogenesis and management. | acne vulgaris is a common skin disorder. although it is most prevalent in the second decade of life, its beginnings are heralded by increased activity of the sebaceous glands and faulty follicular keratinization, which are already evident in mid to late childhood. the subsequent and increasing proliferation of the follicular anaerobic diphtheroid microflora contribute further as an important pathogenic factor in the generation of inflammatory lesions. treatments of acne, therefore, are aimed at ... | 1986 | 2941198 |
| [treatment of skin changes in acne using propionibacterium antigens in the form of an oral vaccine]. | | 1986 | 2942740 |
| qualitative and quantitative changes in cutaneous bacteria associated with systemic isotretinoin therapy for acne conglobata. | quantitative cultures in 40 patients treated with systemic isotretinoin demonstrated a significant reduction in the anaerobic diphtheroid, propionibacterium acnes within one month of therapy and a continued suppression during 5 months of treatment. this reduction persisted after discontinuation of isotretinoin therapy despite a return of sebum excretion to pretreatment levels. surface aerobic bacteria showed a significant reduction in the total number of organisms and significant qualitative cha ... | 1986 | 2943823 |
| rational therapy for acne vulgaris: an update on topical treatment. | acne vulgaris is a disorder of sebaceous follicles that usually begins at the time of the sharp increase in androgen production that occurs in adolescence. this disease is most prevalent among teenagers, but it does occur in patients in their twenties and thirties. three major areas of pathophysiology have been identified in acne: hyperkeratinization and obstruction of sebaceous follicles, resulting from abnormal desquamation of follicular epithelium; an androgen-stimulated increase in the produ ... | 1986 | 2945846 |
| the in vitro antimicrobial effect of azelaic acid. | various strains of cutaneous micro-organisms were tested in vitro for their survival rates in 0.5 mol/l (8.4% w/v) azelaic acid solution. all bacterial strains exhibited large reductions in viability (at least 40-fold) over a 24 h test period, but little response was noted with pityrosporum ovale. the bactericidal effect of azelaic acid was reduced considerably in the presence of nutrients. minimum inhibitory concentrations (mics) and minimum bactericidal (or fungicidal) concentrations (mbcs) we ... | 1986 | 2947607 |
| photodestruction of endogenous porphyrins in relation to cellular inactivation of propionibacterium acnes. | during growth of propionibacterium acnes on eagles medium protoporphyrin was accumulated inside the cells and coproporphyrin, both as a free base as metalcontaining, outside the cells. the photochemical processes in the endogenous porphyrins were studied by fluorescence spectroscopy during continuous irradiation of propionibacterium acnes in suspension. the irradiation caused initially an increase in the content of protoporphyrin in the cells in comparison to that which had been accumulated duri ... | 1986 | 2948330 |
| comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris. | a 2.5% formulation of benzoyl peroxide was compared with its vehicle, and with a 5% and a 10% proprietary benzoyl peroxide gel preparation in three double-blind studies involving 153 patients with mild to moderately severe acne vulgaris. the 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules). desquamation, erythema, and symptoms of burning with the 2.5% gel wer ... | 1986 | 2948929 |
| in vitro and in vivo evaluation of a-56268 (te-031), a new macrolide. | the in vitro and in vivo antibacterial activity of a-56268 (te-031), the 6-o-methyl derivative of erythromycin, was compared with those of erythromycin and other reference drugs. a-56268 had the same spectrum of antibacterial activity as erythromycin. a-56268 was generally 1 log2 dilution more potent or equal to erythromycin against all organisms except haemophilus influenzae and propionibacterium acnes, for which a-56268 was 1 log2 dilution and 3 log2 dilutions, respectively, less potent. the m ... | 1986 | 2949695 |
| antigen-specific suppression of the in vitro cytotoxic response by a soluble factor produced by corynebacterium parvum-induced allospecific suppressor cells. | the adjuvant corynebacterium parvum, when administered intravenously during an ongoing alloimmunization, induces alloantigen-specific splenic suppressor cells which inhibit primary and secondary in vitro sensitizations. we have previously shown that these cells produce a soluble suppressor factor in culture. we now further characterize this factor and its mechanism of action. release of this suppressive factor is dependent upon specific restimulation of the splenic suppressor cell with the sensi ... | 1987 | 2949854 |
| [antibiotic susceptibility of propionibacterium acnes; changes in the last 15 years at the department of dermatology, kansai medical university]. | | 1986 | 2951538 |
| uptake of protoporphyrin and violet light photodestruction of propionibacterium acnes. | the uptake of protoporphyrin ix by propionibacterium acnes in suspension has been studied by fluorescence spectroscopy. protoporphyrin, after it was injected into a cell suspension, was firstly bound to receptors on the cell surface and in this state protoporphyrin was non-fluorescent. subsequently, probably as a result of lateral diffusion in the cell wall, these protoporphyrin-receptor complexes formed dimers. the final step in the overall uptake process of protoporphyrin by the cells from the ... | 1987 | 2953128 |
| no photoinactivation of propionibacterium acnes with soft laser treatment. | | 1987 | 2956136 |
| antibodies to p. acnes and p. acnes exocellular enzymes in the normal population at various ages and in patients with acne vulgaris. | total serum igm and igg agglutinins to p. acnes and neutralizing antibodies to p. acnes lipase, hyaluronate lyase and acid phosphatase were measured in normal individuals of different age groups. agglutinins to p. acnes were detected in infants at 4 months of age and were present at a high level throughout life. a switch from predominantly igm agglutinins in children, to igg agglutinins in adults, occurred during adolescence. anti-p. acnes lipase antibodies were present in 20% of teenagers and 1 ... | 1987 | 2956986 |
| [pathomechanism, bacteriology and treatment of acne changes]. | | 1987 | 2957292 |
| the production of inflammatory compounds by propionibacterium acnes and other skin organisms. | culture supernatants from four species of skin microorganisms (p. acnes, p. avidum, p. granulosum and s. epidermidis) were assayed for smooth muscle contracting substances which are indicative of inflammatory activity. at least three types of smooth muscle contracting substances were detected. these were: first, a substance active on a rat fundic strip preparation and antagonized by n,n-dmt. activity was enhanced when cultures were grown in the presence of tryptophan. this substance was probably ... | 1987 | 2958076 |
| [occurrence and levels of serum antibodies against propionibacterium antigens in persons of various ages]. | | 1987 | 2959828 |
| in vitro activity of vancomycin and teicoplanin against anaerobic bacteria. | the in vitro activity of vancomycin and teicoplanin, a new glycopeptide antimicrobial, was determined against a total of 286 anaerobic bacteria including bacteroides fragilis group (100), b. melaninogenicus (21), b. bivius (16), fusobacterium spp. (15), peptococcus spp. (20), peptostreptococcus spp. (21), clostridium perfringens (23), c. difficile (41) and propionibacterium acnes (29). minimum inhibitory concentrations (mic) were determined using an antimicrobial incorporation technique in wilki ... | 1987 | 2962846 |
| azelaic acid. | this review is an update on the literature accumulated over the past 10 years following the original observation that azelaic acid, a naturally occurring and nontoxic c9 dicarboxylic acid, possesses significant biologic properties and a potential as a therapeutic agent. these studies have shown that azelaic acid is a reversible inhibitor of tyrosinase and other oxidoreductases in vitro and that it inhibits mitochondrial respiration. it can also inhibit anaerobic glycolysis. both in vitro and in ... | 1987 | 2963038 |
| the microbial colonization of inflamed acne vulgaris lesions. | seventy one papules in the early stages of inflammatory development were isolated from acne vulgaris affected skin and their content of micro-organisms characterized. the progress of lesions prior to excision was monitored by tracing an area of the upper back onto a transparent acetate sheet. this template was used the next day, and in some cases after 3 days, to identify inflamed lesions of less than 1 day and 2-3 days duration. these were biopsied, and pilosebaceous units isolated by micro-dis ... | 1988 | 2964856 |
| [propionibacterium acnes septicemia in a mycosis fungoides]. | | 1988 | 2970819 |
| the antibiotic susceptibility of propionibacterium acnes: a 15-year bacteriological study and retrospective evaluation. | | 1988 | 2971698 |
| acne vulgaris and malignancy. | seventy patients with lymphomas and leukaemias were interviewed. details of past acne vulgaris were recorded and a clinical examination performed. a history of acne was less common in the patients than in matched controls. in addition, fewer patients had received treatment prescribed by a medical practitioner for their acne than had the controls. examination revealed fewer patients with acne. these results suggest a reduced incidence of acne or its more severe forms in patients who have develope ... | 1988 | 2974720 |
| granulocyte activating factor released from propionibacterium acnes. a possible mediator of inflammation in acne vulgaris. | incubation of propionibacterium acnes but not of propionibacterium granulosum or propionibacterium avidum (for 30 min at 37 degrees c in physiological saline) released a soluble factor that produced enhanced chemiluminescence response of human granulocytes as well as increased chemotactic motility of these cells. sephadex g-25 filtration of the granulocyte activating factor (gaf) revealed its low molecular weight and apparent peptide character. thus, gaf may be a stimulus for inflammation in acn ... | 1988 | 2975904 |
| an ultrastructural examination of murine alveolar macrophages following intranasal administration of propionibacterium acnes. | light and electron microscopic analysis of murine lungs or isolated pulmonary cells was performed three days after intranasal administration of the bacterial immunostimulant, propionibacterium acnes (p. acnes). our observations indicated that pulmonary alveolar and airway macrophages (pams) were the only cells with p. acnes bacilli in their cytoplasm. bacilli were not observed in pulmonary interstitial macrophages, granulocytes, lymphocytes or pulmonary parenchymal cells such as type i and type ... | 1987 | 2980723 |
| activation of mouse macrophages causes no change in expression and function of phorbol diesters' receptors, but is accompanied by alterations in the activity and kinetic parameters of nadph oxidase. | mouse peritoneal macrophages activated in vivo by the injection of corynebacterium parvum release larger amounts of superoxide anion (o2-) than macrophages from control mice when stimulated with phorbol myristate acetate (pma). the biochemical bases for this enhanced response of activated macrophages have been investigated by studying the expression and function of receptors for the stimulant, and the activity of the enzyme nadph oxidase which is responsible for the production of o2- in leucocyt ... | 1985 | 2981767 |
| susceptibility of propionibacterium acnes to killing and degradation by human neutrophils and monocytes in vitro. | propionibacterium acnes, the target of inflammation in acne, was tested for its sensitivity to the bactericidal and degradative functions of human polymorphonuclear leukocytes (pmn), monocytes, and their fractions. p. acnes strains were not killed by pmn under any conditions and were variably killed by monocytes in the presence of serum from acne patients. control strains of staphylococcus aureus and micrococcus lysodeicticus were susceptible to both pmn and monocyte killing. p. acnes strains we ... | 1985 | 2989178 |
| oxygen-derived free radicals promote hepatic injury in the rat. | we have investigated the possible protective effect of superoxide dismutase and allopurinol in a rat model of mild and severe hepatic necrosis produced by corynebacterium parvum with or without endotoxin. histology showed a sinusoidal mononuclear cell infiltrate with multiple granulomata but variable degrees of hepatic necrosis. in the severe hepatic injury model there was a reduction in mortality, associated with a decrease in histologic and biochemical evidence of hepatic necrosis, after treat ... | 1985 | 2995189 |
| protease production by microorganisms associated with reproductive tract infection. | factors influencing pathogenicity of various microbes found in the female lower genital tract remain incompletely understood. protease production by cervico/vaginal microorganisms may alter or inactivate a variety of proteins important in host defense and structural-functional integrity including collagen-containing chorioamniotic membranes and uterine cervix. host tissues may be made more susceptible to other organisms' virulence factors by protease-producing members of genital tract local flor ... | 1986 | 3004213 |
| deficient ifn alpha production in hairy cell leukemia. | since the application of low doses of ifn-alpha is necessary to maintain remissions in hairy cell leukemia (hcl) it is of interest whether peripheral blood mononuclear cells (mnc) of hcl patients can be induced in vitro to produce ifn-alpha. 9 patients suffering from advanced hcl were included in the study. the diagnoses were confirmed by characteristic findings in peripheral blood and bone marrow biopsies. for ifn treatment we initially used natural ifn-alpha (bioferon) and switched later to re ... | 1986 | 3006840 |
| distribution of intrapleural and intravenous corynebacterium parvum in humans; 99mtc-, and 131i-labeled bacteria. | the distribution of corynebacterium parvum labeled with 131iodine or 99mtechnetium was studied in 17 patients with bronchogenic carcinoma. the labeled bacteria were given intravenously or intrapleurally and monitored by whole-body gamma tracking and samples of blood and urine. even though the rate of physical decay is quite different for 131iodine and 99mtechnetium, the tracking time of labeled bacteria was limited to 24 h after injection for both radioactive isotopes. technetium labeling was pr ... | 1986 | 3011262 |
| protection of mice against herpes simplex virus infection by a lactobacillus casei preparation (lc 9018) in combination with inactivated viral antigen. | heat-killed lactobacillus casei yit 9018 (lc 9018) cells enhanced the resistance to herpes simplex virus type 1 (hsv-1) in adult mice, but not significantly. the protection of mice against hsv-1 infection and the production of neutralizing antibodies were significantly enhanced by the administration of lc 9018 in combination with inactivated hsv-1 antigen. the optimal enhancement of resistance was seen in mice 14 days after the simultaneous administration of these substances. the resistance to h ... | 1986 | 3012292 |
| possible polyclonal b cell activation in mucocutaneous lymph node syndrome. | immunoserological studies on polyclonal b cell activation were carried out on 39 patients with mucocutaneous lymph node syndrome (mcls) and in age-matched healthy individuals. the incidence of anti-mite, p. acnes (kato) and eb virus antibodies, recently proposed as aetiological agents by some investigators, was increased in the patient group. serum immunoglobulin (ig) m level and igm-anti-dinitrophenyl (dnp) antibodies, which are considered to be parameters of polyclonal b cell activation, were ... | 1986 | 3015624 |