| [haemophylus influenzae. morbidity and the problem of specific prevention]. | | 1979 | 115185 |
| nitroblue tetrazolium (nbt) reduction by bacteria. some properties of the reaction and its possible use. | all the s. albus, e. coli and p. aeruginosa strains examined reduced nitroblue tetrazolium (nbt) to dark blue formazan. the amount of formazan produced was proportional to the number of bacteria. under the same growth conditions, an equal number of bacteria of various strains produced different amounts of formazan. however, there were statistically verified differences in the nbt-reduction between the three species examined. the nbt-reduction took place in all phases of growth but was most inten ... | 1979 | 115226 |
| pharmacological modification of experimental tardive dyskinesia. | cebus apella monkeys subjected to chronic haloperidol administration develop neurologic disturbances very similar to neuroleptic-induced acute dystonia human beings. after varying lengths of time, certain monkeys develop a prolonged dyskinetic syndrome resembling tardive dyskinesia (td), as seen clinically. two monkeys with signs of td were given single intramuscular injections of various compounds with known effects on the catecholaminergic, cholinergic, serotoninergic and gaba-ergic neurotrans ... | 1979 | 115227 |
| a pharmacological and in vitro comparison of three oral cephalosporins. | the pharmacology of cephradine, cephalexin and a new oral cephalosporin, cefaclor, has been compared in six volunteers. cefaclor was absorbed rapidly and was cleared from the serum more rapidly than the other two agents. this was probably partially due to its instability in serum at body temperature, which was investigated. against a wide range of common pathogens cefaclor was the more active oral cephalosporin. in particular the activity against neisseria gonorrhoeae and haemophilus influenzae ... | 1979 | 115833 |
| commissural columns in the sensory-motor cortex of monkeys. | callosally projecting cells and the terminal ramifications of their axons were identified in the monkey sensory-motor cortex by retrograde and anterograde labeling techniques, often by double labeling cells and axons in the same animal. bundles of callosal fibers terminate in small column-like zones 0.5-1 mm wide in the motor cortex (area 4) and in the first (si) and second (sii) somatic sensory areas. such columns are aligned in register to form elongated strips extending mediolaterally in the ... | 1979 | 115905 |
| [an experimental study on pseudomonas osteomyelitis with special reference to the production of experimental osteomyelitis in mice (author's transl)]. | i) the author has successfully produced a model of experimental osteomyelitis caused by pseudomonas aeruginosa using the following procedure though such a demonstration has been said to be very difficult. after impregnation in a solution containing about 10(5) pseudomonas aeruginosa, 3 mm silk thread of no. 5 was dried under low-pressure atmosphere and then inserted into the metaphysis of right tibia of a mouse. this method can be produced experimental osteomyelitis in 100% of the animals. in th ... | 1979 | 115949 |
| putreanine in developing monkey brain: relation to polyamines. | | 1979 | 115966 |
| long-term effects of early undernutrition and environmental stimulation on learning performance of adult rats. | early undernutrition was achieved in rats by increasing litter size; the undernourished groups were reared from birth to 21 days in litters of 18 pups per dam and the control groups in litters of six pups per dam. each of these groups was divided at weaning into two sub-groups: previously undernourished, stimulated (pus+) and non-stimulated (pus-); and control, stimulated (cs+) and non-stimulated (cs-). from weaning, all animals were fed ad libitum. environmental manipulation began at weaning an ... | 1979 | 115974 |
| focal epithelial hyperplasia in rabbit oral mucosa. | several papules on the floor of the mouth and the ventral surface of the tongue of a zinc-deficient rabbit were studied by light and electron microscopy. these papules appeared to be consistent with focal epithelial hyperplasia of man and chimpanzees. there was a concurrence of cytoplasmic vacuolization with the appearance of viral particles within the nucleus. intranuclear crystalline viral aggregates were frequently observed in the upper spinous cells. | 1979 | 115979 |
| influence of dietary protein on the anti-inflammatory and ulcerogenic effects and on the pharmacokinetics of phenylbutazone in rats. | influence of dietary protein deficiency on the anti-inflammatory and ulcerogenic effects and on the kinetics of phenylbutazone was studied in male sprague-dawley rats fed ad libitum a 21% (control) or a 5% (low) protein diet for 3 weeks. a low protein diet fed to a decrease in body weight gain, plasma proteins, albumin, globulins, hepatic total and microsomal proteins and in cytochrome p-450. phenylbutazone produced a greater ulcerogenic effect in rats fed a low protein diet than in control rats ... | 1979 | 115991 |
| organization of nucleolar dna in resting lymphocytes as revealed by the diaminobenzidine technique. | | 1979 | 116008 |
| dietary salt (sodium) and hypertension. | | 1979 | 116541 |
| effects of biorhythms on blood flow distribution in the pregnant uterus (macaca mulatta). | ten rhesus monkeys were studied between 143 and 161 days of gestation. the unanesthetized animals were confined to restraining chairs and maintained in a controlled environment with continuous monitoring of spontaneous uterine dynamics. forty-five determinations of blood flow distribution were made using radionuclide-labeled microspheres. the microsphere injections confirmed a circadian pattern of uterine blood flow. these biorhythms are related to alterations in distribution of blood flow to pl ... | 1979 | 116548 |
| mineralization of the enamel of ovine permanent central incisor teeth using microhardness and histological techniques. | | 1979 | 116728 |
| restriction of plasmid-mediated transformation in bacillus subtilis 168. | when plasmids carrying leucine genes of bacillus subtilis 168 were isolated from a restriction and modification deficient (r-m-) strain and used for transformation of a restricting strain b. subtilis 168 leu rece4, the number of transformants was greatly reduced. transformation of rec+ strain (transformation by integration of the donor dna into the chromosome) with the plasmids was not affected irrespective of whether the recipient carried the r+ or r- phenotype. these results show that the plas ... | 1979 | 117281 |
| study of the anti-tumor effect of polypeptide pineal extract. | bovine pineal polypeptide extract (ppe) exerted an anti-tumor effect on mouse-transplantable tumors: mammary cancer (rsm), squamous cell cervical carcinoma (scc), hepatoma-22a and lympholeukemia lio-1, and had no effect on harding-passey melanoma and leukemia l-1210. it was shown that ppe possessed the ability to decrease the incidence of dmba-induced mammary adenocarcinomas in rats. the daily administration of 0.5 mg ppe prolonged the life span of rats by 25% and failed to influence spontaneous ... | 1979 | 117414 |
| cost-benefit studies of vaccinations in finland. | the benefits of vaccination are, in general, recognized. for some diseases these benefits are obvious. when starting or evaluating new vaccination programmes, a more critical approach is needed. before starting vaccination against measles and rubella in finland a cost-benefit study was performed. according to those studies the net benefits of each vaccination would be ca. 100 million finnish marks in 25-30 years. those benefits not measurable in money value of human life, decrease of suffering, ... | 1979 | 118069 |
| [modelling modification of chemical mutagenesis in human cells. iii. linear index of protection as the standardized criterion of modification]. | the effect of substances with radioprotective activity, apaetp 2,3 (aminopropylaminoethylthiophosphoric acid 2,3), apaetp 3,3 and cystaphos, on chromosome aberrations, induced by thiotepa in the culture of human lymphocytes was investigated. it is shown that the obtained curves "concentration -- effect" for thiotepa can be described by equations rho = 1 -- e-(kc + alpha)2 and x = e -(kc + alpha)2 --1 for aberrant cells and for chromosome breaks in the presence of the investigated substances. on ... | 1979 | 118079 |
| isolation and characterization of recombinant dna plasmids carrying drosophila trna genes. | recombinant plasmids carrying drosophila melanogaster trna genes were constructed by ligation of hindiii-cleaved drosophila dna to hindiii cut pbr322 dna. 90 clones were isolated that contained genes for one or more of eleven trnas. 43 of the plasmids were characterized by a number of methods: restriction nuclease digestion; agarose gel electrophoresis; hybridization with individual, purified, 125i-labelled drosophila trna molecules and in situ hybridization to drosophila chromosomes. the result ... | 1979 | 118082 |
| significance of the detection of beta-galactosidase and of beta-xylosidase in the taxonomic study of the genus haemophilus. | a total of 314 strains of haemophilus, isolated from clinical samples, were studied for the production of beta-galactosidase and beta-xylosidase. none of the h. influenzae strains studied (9 beta-lactamase positive strains and 129 beta-lactamase negative strains) possessed these enzymes. both enzymes were almost constantly observed among strains of h. paraphrophilus (10 strains studied) and of h. paraphrohaemolyticus (9 strains studied). among the other species (h. parainfluenzae, 55 strains; h. ... | 1979 | 118191 |
| comparison of two antigen detection techniques in a primate model of haemophilus influenzae type b infection. | rapid diagnosis of haemophilus influenzae type b meningitis is possible using immunological tests for capsular antigen (polyribophosphate, prp), such as countercurrent immunoelectrophoresis (cie) and latex particle agglutination (lpa). we compared two tests in monkeys with evolving, serially quantitated h. influenzae type b bacteremia (n = 23) and meningitis (n = 21). in vitro, the lpa test was sensitive to 0.5 ng of prp/ml of saline, and the cie test was sensitive to 1.0 ng/ml; in serum, howeve ... | 1979 | 118934 |
| serological grouping of meningococci and encapsulated haemophilus influenzae strains by latex agglutination. | the latex agglutination method, utilizing antibody-coated latex particles, was adapted for serogrouping of neisseria meningitidis and serotyping of encapsulated haemophilus influenzae strains from agar plates. it was found to give more clear-cut results than conventional slide agglutination. a 100% agreement with the antiserum agar method was found for all strains isolated from blood or cerebrospinal fluid. many meningococcal strains from nasopharyngeal carriers are autoagglutinable, but some of ... | 1979 | 118981 |
| [drug resistance of bacteria isolated from patients with chronic nonspecific broncho-pulmonary diseases]. | | 1979 | 119214 |
| [studies on the influence of various factors in phagocytic process with sera of rabbits immunized by an extract from "haemophilus influenzae" type a (author's transl)]. | | 1979 | 119456 |
| effect of antibiotics on the formation of specific antibodies. | immune response to staphylococcal haemolysin and haemophilus influenzae capsular antigen administered simultaneously with antibiotics was studied in rabbits. in addition to specific humoral antibodies, the quantitative values of igg, iga, igm and c'3 complement were determined. statistically significant deficiency of immune response was observed in all cases in animals which were given the antigen with the antibiotic in comparison with the controls which were immunized by the antigen alone. stat ... | 1979 | 119810 |
| nucleotide binding to glycogen phosphorylase b in the crystal. | | 1979 | 119868 |
| pharyngeal beta-hemolytic streptococci: a study in american military dependent children stationed in west germany. | | 1979 | 119925 |
| effect of inosine on warm renal ischemia in monkeys and dogs. | | 1979 | 120023 |
| synchronization of eeg activity of male rhesus monkeys macaca mulatta treated with ovocyclin. | bipolar stainless steel electrodes were stereotaxically implanted in hypothalamus and cortex of six male monkeys. the effect of intramuscular injection of estradiol dipropionate (ovocyclin) in a dose of 10 mg/d was observed on eeg activity on 3 successive days. on the first day, slow waves appeared only in preoptic and on the second day also in posterior hypothalamus. generalized slowing with an increase in amplitude appeared in all the hypothalamic areas and cortex on the third day. this sugges ... | 1979 | 120113 |
| residues of ddt in a norwegian fruitgrowing district two and four years after the termination of ddt usage. | this study describes the extent of ddt contamination in a typical fruit growing district in norway two and four years after the ddt ban. residues of ddt in man, dairy cows and soil were about five to one hundred times higher than in the control groups, while residues found in samples from the marine biota were the same or moderately higher (figure 3). the residues of ddt in cows, gulls and parts of the marine samples showed a significant decrease from 1972 to 1974, while the level in soil was al ... | 1979 | 120139 |
| [effect of enkephalin and morphine on gastric secretion and gastric blood flow]. | | 1979 | 120296 |
| nervous functioning during ontogenesis: facts and reflections. | | 1979 | 120624 |
| lipid pattern of erythrocyte membrane of calf and adult cattle. | | 1979 | 120656 |
| experimental studies on the mechanism of the nitroglycerin effect. | the regional decrease of the speed and extent of the contraction and the relaxation of the canine myocardium induced by coronary ligation was enhanced by intravenously administered nitroglycerin (gtn), simultaneously with the decrease of the left ventricular pressure, while the increase of myocardial fiber length caused by that procedure was partly abolished. the above changes could be reproduced by gtn applied directly onto the ischaemic myocardial surface even before the decrease of the left v ... | 1979 | 120673 |
| [measles and temporary increase in masculine births: coincidence or causality?]. | data from three west-african populations shows significant increase of sex-ratio. in two of them a considerable excess of male births came from conceptions the year following an epidemic of measles. this is limited to the villages affected by this epidemic. these facts seem to be similar to those related to hepatitis and sex-ratio. they suggest similarities between measles virus and surface antigens of y sperms. this hypothesis could be tested by immunological investigation. | 1979 | 120780 |
| [identification of a virus similar to hepatitis b virus in non-a non-b hepatitis]. | hepatitis b virus-like particles (including dane particles) with dna polymerase activity but negative for hbs ag have been identified in non-a, non-b hepatitis sera positive for hc ag. although specifically associated with the particles, hc ag is not a surface antigen of the hepatitis c virus identified here for the first time. the relationship of this agent with hbv seems obvious, and deserves further study. | 1979 | 120782 |
| [vitamin d and reproduction in wistar rats]. | females have received from weaning a semi-synthetic diet (0,35% ca; 0,32% p; 0,03% mg), with or without vitamin d (+/- d). fertility of these females was not changed. at weaning, the young from mothers--d had lower weight, calcemia and phosphatemia, but the ash content of the femur was the same as for young from mothers + d. young rats from mothers +/- d were given the diet with or without vitamin d. 19 days after weaning, the diet of the mother (+/- d) appears to be the principal factor for gr ... | 1979 | 120790 |
| [effect of progesterone on male and female sex behavior induced by steroid hormones in adult ovariectomized ewes]. | ovariectomized adult ewes daily treated with i/m injections of testosterone propionate (10 mg/day) or oestradiol benzoate (200 microgram/day) show male-like sexual behaviour and simultaneously a permanent female receptivity. additional daily treatment with 100 mg of progresterone results in a rapid decrease in male sexual responses both when ewes are treated with testosterone and with oestradiol. no effect is observed on the female receptivity. cyproterone acetate (100 mg/day) given to ewes in a ... | 1979 | 120792 |
| barbiturates in neurosurgery. | | 1979 | 120795 |
| the influence of the mode of morphine administration on tolerance and dependence. | | 1979 | 121358 |
| the effect of l-alpha acetyl methadol in morphine-dependent rats. | | 1979 | 121361 |
| the ultrastructural features of laser trabeculopuncture and cyclodialysis. problems related to successful treatment of chronic simple glaucoma. | microexplosions induced by a q-switched nd:glass laser working above optical breakdown power density levels are able to destroy the inner wall of schlemm's canal and to tear open both the supraciliary and suprachoroidal space. furthermore, the ciliary muscles bundles may be disrupted, becoming subsequently permeable to the aqueous and thus also acting as a new outflow route. however, whereas breaks of the inner wall of schlemm's canals are sealed in the monkey by the activity of endothelial cell ... | 1979 | 121373 |
| [therapy of chronic respiratory tract infections in children, including mucoviscidosis (author's transl)]. | in respiratory tract infections in children a distinction must be made between frequently recurring infections and genuine chronic infections due to specific anatomical factors, immunological defects or congenital diseases such as mucoviscidosis. the most frequent pathogens are haemophilus influenzae, pneumococci, staphylococcus aureus, streptococcus pyogenes, enterococci, pseudomonas aeruginosa and klebsiella, s. aureus predominates in infants. the same applies for mucoviscidosis, in which p. a ... | 1979 | 121731 |
| bacterial transformation. | | 1979 | 121792 |
| mutagenicity of nitrosocarbaryl and other methylating nitrosamides as related to uptake in haemophilus influenzae. | differences greater than 6,000-fold in the mutagenic potency of three nitrosamides that are methylating agents [n-methyl-n-nitrosourea (mnu), n-methyl-n'-nitro-n-nitrosoguanidine (mnng) and n-nitrosocarbaryl (nc)] could be accounted for in part by differences in their uptake into the haemophilus influenzae cells. uptake was roughly correlated with the octanol/water partition coefficient. the most potent mutagen, nc, was concentrated by the cells. the least potent, mnu, was essentially excluded f ... | 1979 | 121978 |
| [distribution of different phage types of s. paratyphi b in spain]. | | 1979 | 122277 |
| in vitro activity of piperacillin, a new semisynthetic penicillin with an unusually broad spectrum of activity. | the in vitro activity of piperacillin (t-1220), a new semisynthetic derivative of aminobenzylpenicillin, was investigated. the majority of streptococci and pneumococci were inhibited by 0.12 micrograms/ml; the staphylococci and enterococci were inhibited by 2 micrograms/ml. piperacillin was slightly more active against neisseria and haemophilus influenzae than was ampicillin. piperacillin was active against all members of the enterobacteriaceae including the klebsiella, 58% of which were inhibit ... | 1978 | 122518 |
| [exploration of parotid saliva proteins by means of one-and-two-dimensional immunelectrophoresis, immunodiffusion and discelectrophoresis (author's transl)]. | the protein composition of human parotid saliva was explored by means of one- and two-dimensional immunelectrophoresis as well as by a modified ouchterolony-technique and discelectrophoresis, where usually at least 14 components of parotid-saliva-proteins can be differentiated. according to the results of immunelectrophoresis and discelectrophoresis, the kind and number of protein components are interindividually constant, yet, there are great interindividual differences concerning the concentra ... | 1975 | 123615 |
| micrococcus lysodeikticus atpase. purification by preparative gel electrophoresis and subunit structure studied by urea and sodium dodecylsulfate gel electrophoresis. | micrococcus lysodeikticus atpase was purified by preparative gel electrophoresis after its "shodk wash" release from the membrane. the method afforded the highest yield of pure protein in the minimum time as compared with former purification procedures. the pure protein had a specific activity of 7 mumol pi-min- minus 1-mg- minus 1 with incubation times not longer than 3 min, 345 000 mol. wt and was not stimulated by trypsin. by gel electrophoresis at alkaline ph (8.5) in 8 m urea or in sokiu ... | 1975 | 123783 |
| evidence that the deferential vein acts as a local transport system for androgen in the rat and the dog. | ligation of the deferential vein of the rat has been shown to bring about a reduction in the androgen-dependent activity of the prostatic rna polymerase enzyme. in the dog, the content of androgens in this vein is of the order of that found in the testicular vein and many times higher than that of peripheral plasma. it seems that the cauda epididymidis alone is sufficient to maintain the ipsilateral lobes of the prostate and seminal vesicles providing an intact ductus deferens and contralateral ... | 1975 | 123961 |
| fatal immune complex glomerulonephritis without deposits. | repeated intravenous injections of egg albumin in rabbits produced small antigen-excess complexes and severe glomerulonephritis. immunoglobulins and complement in the glomeruli were not clearly demonstrated by immunofluorescence; deposits were found to be sparse by electron microscopy. this study demonstrates that soluble immune complexes are responsible for the glomerular reaction. the apparent absence of deposits is thus not sufficient to exclude an immune complex pathogenesis. | 1975 | 123971 |
| fenfluramine-induced enhancement of confinement motor activity: an indirect 5-hydroxytryptamine-like action? | | 1975 | 124023 |
| an (8;12) translocation, balanced, 46 chromosomes. repository identification no. gm-213. | | 1975 | 124242 |
| suspected "b"-vitamin deficiency of sheep fed a protein-free urea containing purified diet. | | 1975 | 124720 |
| editorial: acne, soap and chocolate. | | 1975 | 125375 |
| inhibition not facilitation of sexual behavior by pcpa. | it has been proposed that estrous behavior in the female rat may be under tonic inhibition by a central serotonergi system. studies conbining estrogen priming and the pharmacological depletion of serotonin have provided some support for this hypothesis. some evidence, however, is not consistent with this hypothesis. in the present study estrogen primed ovariectomized-adrenalectomized rats were administered p-chlorophenylalanine and were tested for lordosis behavior 66 and 70 hr later. lordosis w ... | 1975 | 125426 |
| activation and inactivation of rat liver phosphofructokinase by phosphorylation-dephosphorylation. | | 1975 | 126176 |
| variable nature of cartilage proteoglycans. | cartilage proteoglycan aggregates are separated from collagen and other non-proteoglycan protein by preparative rate zonal sedimentation under associative conditions. dissociative rate zonal sedimentation produces sedimented proteoglycan of lower protein content with a corresponding increase in the amount of less sedimentable protein-rich proteoglycan. an extensive number of sequential rate zonal sedimentations discloses that the proceess of disaggregation involves the separation of proteoglycan ... | 1975 | 126234 |
| [changes in ventilatory patterns before and after vagotomy in rabbits]. | ventilatory pattern have been investigated during rebreathing experiments. before vagotomy, a linear relation has been found between increasing tidal volume and decreasing inspiratory and expiratory durations. after vagotomy, these relations existed but expiratory duration remained almost constant. | 1975 | 126729 |
| [strontium and calcium metabolism. interaction of strontium and vitamin d]. | oral administration of strontium to calcium wellfed rats blocks the intestinal absorption of calcium. when high doses of vitamine d are given over long period, the inhibition of calcium intestinal absorption disapears. under these conditions the absorption of strontium is increased. it is suggested that there is only one absorption mechanism for these two cations. an overdose of the vitamine d increases the renal elimination of strontium but under these conditions the plasma concentration of the ... | 1975 | 126763 |
| [optical microscopic study of the effect of the hypothalamic hormone t.r.h. on certain cell types of rat anterior hypophysis]. | a cytological and optical microscopic study of the anterior lobe of hypohysis in the wistar adult rat 10, 30 or 60 minutes after intravenous injection of 50 mug of synthetic trh discloses modifications of thyrotropic cells and prolactin cells. it's possible to recognize a quick degranulation of the prolactin cells (with a maximum at the 10th minute) and a slower degranulation of the thyrotropic cells (perceptible at the 10th minute and very pronounced at the 60th minute). the somatrotopic cells ... | 1975 | 126765 |
| [electrofocusing of hydrolases in rat brush border enterocytes]. | different hydrolases (cellobiase, enterokinase, lactase, leucine aminopeptidase, alcaline phosphatase and trehalase) of the brush border's enterocytes of the rat have been studied by electrofocusing. every hydrolase is focused in a single peak, the pi of which is given. | 1975 | 126772 |
| [effect of a beryllium complex on growth of pseudomonas fluorescens (types r and s). i. influence on the lag phase]. | the toxicity of beryllium for pseudomonas fluorescens is studied with the aid of an anionic complex of the element which is stable in peptone medium at ph 6 during the period of investigation. the toxic effect is characterized by an increase in the lag phase which is proportional to the square of the beryllium concentration. further, a process of progressive adaptation is observed when the concentration of the beryllium complex is gradually increased. | 1975 | 126778 |
| letter: safety of retinoic acid in acne therapy. | | 1975 | 126796 |
| effect of methysergide, a blocker of serotonin receptors, on plasma prolactin levels in lactating and ovariectomized rats. | the effect of methysergide (mes, 2.5 mg/100 g body wt), a serotonin antagonist, on prolactin release has been studied in lactating and ovariectomized rats. mes caused significant increases in prolactin release in both animals. studies in ovariectomized, hypophysectomized rats indicate that this effect is not due to a decrease in the peripheral metabolism of prolactin. in vitro incubations of anterior pituitary fragments with mes failed to demonstrate any increase in prolactin release, suggesting ... | 1975 | 126860 |
| amino-acid sequence of the cyanogen-bromide fragment from human plasminogen that forms the linkage between the plasmin chains. | the complete amino acid sequence of a cyanogen bromide fragment (122 residues) obtained from plasminogen is described. this fragment forms the overlap between heavy (a) and light (b) chains of human plasmin. the particular arginyl-valyl bond cleaved in the second step of the activation process is shown to be arg98-val99 in this fragment. this site is not very similar to the one in the nh2-terminal part of the molecule (arg68-met69). remarkable homologies with the 'triple loops' ('kringle structu ... | 1975 | 126863 |
| elementary particles in isolated rat liver and spleen nuclear membranes. | elementary spherical particles similar to those described in the mitochondria are found in isolated rat liver and spleen nuclear membranes. the particles are characterized by electron microscopy of sections and preparations negatively stained with phosphotungstic acid or with the atpase histochemical reaction product. the particles exhibit adenosine triphosphatase activity and have a mushroom-like shape with a sphere about 85-90 angstrom in diameter attached to inner face of the inner nuclear me ... | 1975 | 126876 |
| effects of various drugs on serum free and total tryptophan levels and brain tryptophan metabolism in rats. | various drugs known to bind to serum albumin were examined to determine whether or not they influenced the level of free tryptophan in serum in vitro and in vivo. possible relationships between the serum free tryptophan level and serotonin (5-ht) synthesis in the brain and the hypothermic effects of these drugs were investigated. of the drugs examined, sodium salicylate, sodium benzoate and indomethacin caused a significant increase in the concentration of serum free tryptophan and stimulated th ... | 1975 | 127058 |
| studies of substructure and tightly bound nucleotide in bacterial membrane atpase. | highly purified preparations of streptococcus faecalis atpase contain a similar but inactive protein detected by prolonged polyacrylamide gel electrophoresis. the inactive protein appears to arise by proteolytic cleavage of the major subunits in the enzyme. by use of a new technique, subunit analysis in sds gels was performed on the enzyme band and the inactive protein band excised from a polyacrylamide gel after electrophoresis. the results indicated that the atpase has the composition alpha3be ... | 1975 | 127088 |
| the significance of coronary arterial stenosis during cardiopulmonary bypass. | myocardial infarction may develop during an uneventful open-heart operation. in order to better understand this complication, we undertook an experimental study. the left circumflex coronary artery of 20 dogs was narrowed to 50 per cent of its area by a metal screw clamp to produce a localized coronary stenosis. regional myocardial perfusion in the distribution of both the stenotic circumflex and normal left anterior descending (lad) coronary arteries was measured by injection of a radioactive-l ... | 1975 | 127092 |
| role of mitochondrial calcium metabolism in the altered contractility of pressure-hypertrophied right ventricular myocardium. | pressure-hypertrophied right ventricular myocardium (rvh) demonstrates paradoxically increased oxygen consumption (mvo2) related to increase- in vitro energy-linked mitochondrial calcium flux. the present experiments were designed to measure mitochondrial ca retention in intact rvh and relate changes in mitochondrial ca metabolism to altered rvh contractility and relaxation. sixteen cats were pulmonary artery banded and their hearts plus paired controls were perfused with 45ca-labeled krebs-hens ... | 1975 | 127354 |
| [experiments and theoretical cell kinetic calculations on the problem of in vivo synchronization with vincristine in l 1210 ascites tumor cells and crypt cells of the mouse (author's transl)]. | experiments are described on synchronizing l 1210 ascites tumor cells and jejunal crypt cells of the mouse with vincristine. in both cases the percentage of mitoses increases to a peak value 4 hrs after application of vincristine and decreases during the following 8 hrs ("releasing time") to the level of the normal mitotic index. following this first mitotic peak no futher peak of neither the mitotic nor the labeling index was observed during 48 hrs in l 1210 ascites tumor cells and during 38 hr ... | 1975 | 127443 |
| immunosuppressive activity of heterologous antimacrophage sera. | antisera against rat macrophages were raised in rabbits and tested individually, serologically and in vivo, by injecting 1.5 ml/100 g into lew rats 1 and 4 days following a graft of cdf rat skin. 1. erythrocyte absorption reduced the mean lymphocytotoxic titer of antimacrophage sera from 1:16 to 1:1, but yielded strongly immunosuppressive sera. they extended the graft survival time from the normal rate of 11-14 days up to 217 days. 2. additional absorption with lymphocytes reduced this activity ... | 1975 | 127454 |
| the postnatal development of the white pulp in the rat spleen and the onset of immunocompetence against a thymus-independent and a thymus-dependent antigen. | the spleen of the rat contains 5 well delineated compartments: a central and peripheral part of the periarteriolar lymphatic sheath (pals), the marginal zone and the follicle with centre and corona. a study was made on the development of these compartments in correlation with the onset of immunocompetence of the spleen. the spleens of animals in the age range from 1-40 days were studied with the light and electron microscopes. immunocompetence was assessed by measuring serum antibody levels 5 da ... | 1975 | 127464 |
| the cytotoxic activity of mouse t lymphocytes against allogeneic cytotoxic t cells. | using a 51cr cytotoxicity assay, the sensitivity of murine cytotoxic t cells to t cell mediated cytotoxicity has been tested. two experimental approaches have been used. first, cytotoxic t-blast-lymphocytes (ctbl), enriched by the velocity sedimentation at 1 g were used both as cytotoxic effector cells and as 51cr-labelled target cells. it was found that murine ctbl are capable to lyse directly and specifically allogeneic ctbl within 200 minutes. the second approach used was to incubate ctbl tog ... | 1975 | 127466 |
| reaction of yeast phosphofructokinase with succinic and maleic anhydride. | modification of yeast phosphofructokinase by succinic and maleic anhydride influences the catalytic activity and the allosteric behaviour of the enzyme. depending on the degree of succinylation and maleinylation a decrease of maximum activity, an increase of the apparent affinity for fructose-6-phosphate, a decrease of the hill-coefficient and a diminution of atp-inhibition are observed. up to about 40% of the lysyl residues could be succinylated without dissociation of the hexameric protein, ho ... | 1975 | 127493 |
| ampicillin resistant hemophilus influenzae meningitis in arkansas. | | 1975 | 127777 |
| effect of essential phospholipids on the properties of atpases of isolated rat liver plasma membranes of young and old animals. | "essential" phospholipids (epl), rich in dilinoleyl-phosphatidylcholine were given orally to young and 780-800 day-old rats. the double-labelled (14c/32p) dilinoleyl-phosphatidylcholine was incorporated in plasma membranes and the amounts incorporated into different organs investigated. old animals incorporated higher radioactivity than young. the 14c/32p ratio however decreased in comparison with the substance administered. the amount of (na+-k+)-atpase in rat liver plasma membranes of old anim ... | 1975 | 127894 |
| monoaminergic mechanisms in aversive brain stimulation. | in these experiments we have examined the role of brain monoamines in the fearlike aversive responses produced by the electrical stimulation of the dorsal midbrain tegmentum (dmt). chronic bipolar stimulating electrodes were bilaterally implanted into the dmt of 77 rats. electrical stimulation via 34 of these electrodes produced fearlike, escape seeking responses. these animals were then trained for stable stimulus escape using a decremental bar pressing paradigm. in this paradigm, each bar pre ... | 1975 | 128009 |
| influence of age on orthostatic changes in plasma renin activity and urinary catecholamines in man. | the authors studied plasma renin activity (pra), urinary epinephrine, norepinephrine and dopamine excretion and their mutual relationships in 54 healthy subjects under basal (recumbent) conditions and age-related orthostatic changes in these parameters. the test subjects were divided into six 10-years groups, according to their year of birth (1901-1910 to 1951-1960). in the oldest groups (1901-1910 and 1911-1920), both basal pra values and norephrine and epinephrine excretion and their postural ... | 1975 | 128010 |
| the effect of constant light and chemical sympathectomy on the development of serotonin, n-acetyltransferase and monoamine oxidase activities in the rat epiphyses. | the daytime activity of n-acetyltransferase per mg epiphysis decreased to 1/10 the newborn level by the age of 13 days, and subsequently remained unchanged. the night activity was equal to the day activity at the age of 3 days, was higher at the age of 6 days and was 20 x that of the day level at the age of 40 days. keeping animals in constant light after birth depressed the development of these diurnal differences in n-acetyltransferase activity and slowed down the decrease in enzyme activity a ... | 1975 | 128012 |
| identification and actions of gastric inhibitory polypeptide. | | 1975 | 128084 |
| [biology and classification position of chlamydia]. | | 1975 | 128097 |
| in vitro fertilisation of human oöcytes. | this paper describes attempts to cure infertility due to irremediable fallopian tube lesions by the laparoscopic recovery of pre-ovulatory ovarian oöcytes, their fertilisation in vitro, and their subsequent reimplantation into the uterine cavity. | 1975 | 128140 |
| inhibition of atp synthesis associated with 6-aminonicotinamide (6-an) teratogenesis in rat embryos. | pregnant rats were injected ip with 6 mg/kg 6-aminonicotinamide (6-an) at day 12 of gestation. embryos removed between 1 and 48 h later had reduced adenosine triphosphate (atp) concentrations, of about 50% of control values. all fetuses examined near term were malformed. nicotinamide (nam, 100 mg/kg) given ip 1 h after 6-an afforded protection: malformations occurred in only 15% of the survivors; and there was minimal atp reduction, 15% below control values. nam given 2 and 4 h after 6-an produc ... | 1975 | 128147 |
| normal and aberrant neuronal development in the cerebral cortex of human fetus and young infant. | several approaches utilized in ontogenetic investigations in laboratory animals have been explored in preliminary studies of morphogenetic events in the human cerebral cortex. 1. golgi studies of dendritic growth cones, filopodia, and other developmental processes have permitted specification of the maximal phase of dendritic growth and differentiation of pyramidal neurons in the hippocampus. this period spans the twentieth to twenty-eighth week of fetal development. 2. studies of the temporal p ... | 1975 | 128168 |
| [availability of mg2+, na+, and k+-atpase in the nuclei of the skeletal muscles of rabbits normally and during experimental muscular dystrophy]. | a comparative study was carried out in the properties of atpase system of the skeletal muscle nuclei in the rabbits in norm and with experimental muscular dystrophy conditioned by e-avitaminosis. it is shown that in the system, containing 1.5 mm of mgcl2, atpase system of the nuclei is activated by sodium and potassium ions. in norm maximum activation is observed with their presence in the medium, the concentration being 80 and 70 mm, respectively. with experimental muscular dystrophy maximum a ... | 1975 | 128169 |
| [histological, histoenzymatic and biochemical study of the liver and small intestine of rats during short periods of starvation]. | the structure and the activity of acid phosphatase, beta-glucuronidase, alkaline phosphatase and atp-ase in the liver and small intestine of rats receiving for 20 days a one-time, fixed at a certain time (2 o'clock) feeding was studied morphologically in dynamics in 2, 6, 24 and 48 hours after the last feeding. furthermore, parallel with this the activity of acid phosphatase, beta-glucuronidase, alpha-glucosidase and beta-acetylglucosaminidase was determined in homogenates by biochemical methods ... | 1975 | 128202 |
| the effect of hormone induced stress upon the extent of alkylation of rat liver nucleic acids by n-methyl-n-nitrosourea. | an examination was made of the effect of treatment with methylating agents of varying carcinogenic potency and with stress inducing hormones upon dna synthesis in the resting liver of the rat. with the methylating agents an early stimulation of dna synthesis was observed, but this was depressed below the control levels at later times and with higher doses; hormone administration also resulted in a depression of dna synthesis but, without any initial stimulation at the dosage employed. under cond ... | 1975 | 128216 |
| bacteriophage p13234mo-mediated intra- and intergroup transduction of antibiotic resistance among streptococci. | numerous streptococcal strains representing serogroups a, c, and g were tested for transducibility to antibiotic resistance by the temperate group a streptococcal phage p13234mo. the resistance markers carried by group a donor strains included the erl1 factor determining inducible resistance to erythromycin, lincomycin and streptogramin-b type antibiotics as well as chromosomally located mutations for streptomycin and spectinomycin resistance. erl1, presumably of plasmid nature, was transduced t ... | 1975 | 128266 |
| brain and spinal cord lesions in pigs inoculated with swine vesicular disease (ukg strain) virus and coxsackievirus b5. | pigs inoculated intravenously with swine vesicular disease virus (ukg strain), those inoculated with coxsackievirus b5, and other pigs exposed by pen contact to the same viruses developed diffuse encephalomyelitis. perivascular cuffing, with lymphocytes and formation of neuroglia cell foci, were most prominent in telencephalon, diencephalon, and mesencephalon. encephalitis was of mild to severe intensity. severity of lesions was more extensive and severe in the pigs exposed to swine vesicular di ... | 1975 | 128305 |
| (+)-catechin effects on x-rays irradiated skin of rats. | the effect of (+)-catechin on the skin of rats previously irradiated was a net decrease of amps content and a partial recovery of the insoluble collagen-loss due to x-rays. | 1975 | 128328 |
| editorial: subunits of myosin. relations to atpase activity and mechanical function of muscle. | under certain conditions the specific atpase activity of myosin of a given muscle can be altered. the cause of this alteration can only lie in the myosin molecule itself. to produce an enzymatic activity of myosin, an interaction between their light and heavy chains is necessary. however, the specific activity appears to be determined mainly by light chains. hence, one ought also to look for a basis of the changed activity in changes of the subunits of myosin. there are strong indications that t ... | 1975 | 128346 |
| inactivation of carotenoid-producing and albino strains of neurospora crassa by visible light, blacklight, and ultraviolet radiation. | suspensions of neurospora crassa conidia were inactivated by blacklight (bl) radiation (300 to 425 nm) in the absence of exogenous photosensitizing compounds. carotenoid-containing wild-type conidia were less sensitive to bl radiation than albino conidia, showing a dose enhancement factor (def) of 1.2 for dose levels resulting in less than 10% survival. the same strains were about equally sensitive to shortwave ultraviolet (uv) inactivation. the kinetics of bl inactivation are similar to those o ... | 1976 | 128556 |
| [0utbreak of anaerobic enterotoxemia of calves]. | | 1975 | 129914 |
| cross-circulation study of natriuretic factors in postobstructive diuresis. | to study the role of circulating natriuretic factors in the postobstructive diuresis that occurs after relief of bilateral, but not unilateral ureteral ligation, cross-circulation was carried out between normal recipient rats and donor rats have either 24-h bilateral (bul) or unilateral (uul) ureteral ligation. with bul donors, there was a rapid marked increase in sodium and water excretion in the recipient rats, sustained for 80-140 min, with a peak approximately 10 times control values. with u ... | 1976 | 130386 |
| studies on in vitro carcinogenesis. i. autoradiographic and biochemical study on the incorporation of labelled methylcholantrene into mouse embryonic cells. | the incorporation of radioactive labelled methylcholanthrene into cba/t6t6 mouse embryonic fibroblast cultures was studied by using light and electronmicroscopic autoradiographic and also liquid scintillation counting techniques. during 24 hrs treatment time at the applied methylcholanthrene concentrations (0.01-2.5 mug/ml) the proportion of cells labelled with 3h-methylcholanthrene and the number of grains above the cells showed a relationship with the duration of treatment and also with the do ... | 1976 | 130740 |
| [morphological and biochemical studies on the retinal blood vessels of streptozotocin diabetic rats (author's transl)]. | | 1975 | 130794 |
| [histochemical study of carbonic anhydrase and hco3(-)-stimulated adenosine triphosphatase in the rat stomach during hydrochloric acid secretion]. | by means of histochemical methods it was established that carboanhydrase of the parietal cells of fundal glands and hco-3 stimulated atp-ase of the rat's gastric mucosa capillaries disposed next to the parietal cells were activated by food and histamine. the obtained data confirm the idea of the multicellular functional essembly sustaining hcl secretion (r. i. salganik, 1974). should gastrin induce the formation of histamine in endocrinous cells and the histamine activate carboanhydrase in parie ... | 1976 | 130854 |
| uncoupling of mitochondrial oxidative phosphorylation by thallium. | | 1976 | 130908 |