| duodenal ulcer, gastric acid, and helicobacter pylori. | | 1991 | 2059691 |
| transport conditions and number of biopsies necessary for culture of helicobacter pylori. | stuart's transport medium with a charcoal impregnated swab was tested for transport of biopsies from the gastric antrum for culture of helicobacter pylori. biopsies were cultured under microaerophilic conditions either within 2 h or after a delay of 24 h at 4 degrees c. in 65 patients referred for gastroscopy two biopsies were taken. helicobacter pylori was found in 39 patients. the rate of survival of helicobacter pylori was found to be as high in stuart's transport medium after 24 h at 4 degre ... | 1991 | 2060517 |
| biotype and macromolecular profiles of cytotoxin-producing strains of helicobacter pylori from antral gastric mucosa. | biotype, genome, protein and plasmid profile diversity amongst 40 epidemiologically unrelated strains of helicobacter pylori was studied. strains were api zym biotypes ii, iii and iv but most (87%) were biotype ii. four subsets of strains were defined on a combination of motility (56% positive) and cytotoxin production (44% positive). a close association (p = 0.45) between these two features was observed for 69% of strains. each strain of h. pylori had a unique dna type defined by either haeiii ... | 1991 | 2060760 |
| helicobacter pylori infection--its prevalence and diagnosis in israel. | | 1991 | 2061022 |
| chronic atrophic gastritis in a population at risk for gastric carcinoma. | gastric mucosa of 585 patients at risk for gastric carcinoma and undergoing oesophago-gastroscopy for dyspeptic symptoms was examined histologically and histochemically. sixteen (2.7%) of the patients studied showed gastric carcinoma. the intestinal type of gastric carcinoma was the most common, present in males over 40 yrs old, and was found in 1:16. early cancers were present in 3 patients. chronic atrophic gastritis of the a, b and ab types was present in 32.8%. types a and ab were noted spor ... | 1991 | 2064339 |
| underestimation of helicobacter pylori infection rate by biopsy urea broth test. | | 1991 | 2064505 |
| [effect of fu-zheng qu-xie on gastric disease infected with campylobacter pyloridis]. | chinese herbal medicine and gentamycin were used separately in the treatment of 75 cases of gastric disease by campylobacter pyloridis (cp). surveying the changes of the gastrofiberscope, pathological test, bacteriology and immunology. this study, found that in the chinese herbal medicine group clinical symptoms were obviously improving the effective rate for cp being 80% (24/30), the death rate for cp 30% (9/30), and the effective rate for patho-histological changes 50% (15/30). differences of ... | 1991 | 2065393 |
| helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa. | the authors' previous observation that many of the monoclonal antibodies against helicobacter pylori cross-react with the cells of the human gastric mucosa prompted them to investigate the possibility that gastric self-antigens cross-reacting with h. pylori could be involved in the immune response against this organism. it was found that three antibodies against h. pylori, cb-4, cb-10, and cb-14, that cross-react with the human gastric mucosa also intensely cross-reacted with murine gastric epit ... | 1991 | 2065920 |
| detection and identification of helicobacter pylori by the polymerase chain reaction. | a polymerase chain reaction for the specific detection of helicobacter pylori was developed using a primer pair derived from the nucleotide sequence of the urease a gene of h pylori. specific amplification of a 411 base pair dna fragment from all strains of h pylori tested was achieved. ten organisms were detected using the pcr and the technique permitted direct detection of h pylori in clinical biopsy samples. pcr will be useful for both prospective and retrospective investigation of the aetiol ... | 1991 | 2066432 |
| helicobacter pylori and abo blood groups. | a serological study was carried out to assess the prevalence of antibodies to helicobacter pylori and compare it with the distribution of abo blood groups. serum samples from 402 healthy blood donors were tested with an igg enzyme linked immunosorbent assay. there was no difference in blood groups between those who were seropositive and those who were seronegative, which suggests that blood group o is not a risk factor for acquiring h pylori infection. | 1991 | 2066433 |
| pharmacokinetics of cefuroxime and ciprofloxacin in gastric mucosa: comparison to in vitro inhibitory concentrations against helicobacter pylori. | antibiotic concentrations in serum and gastric mucosa were measured in a previously described animal model (antimicrob agents chemother 1990; 34:25-28) using a high-pressure liquid chromatography (hplc) technique. cefuroxime 30 mg/kg, and ciprofloxacin 20 mg/kg were given by intramuscular injection. cefuroxime showed a bimodal tissue concentration curve with an initial mucosal peak of 2.97 micrograms/g at 1 hour. after falling to undetectable levels, a second peak of 1.47 micrograms/g occurred a ... | 1991 | 2067414 |
| chronic active gastritis after eradication of campylobacter (now: helicobacter) pylori. results of a medium term follow-up study. | 11 patients with c.p.-associated chronic gastritis underwent a triple therapy with bismuth-subsalicylate, amoxicillin susp. and metronidazole. the c.p.-status and the inflammation parameters "polymorphonuclear leucocytes in the epithelium". "polymorphonuclear leucocytes in the lamina propria", "lympho-plasmacellular infiltrate in the lamina propria", "congestion and edema of the lamina propria" and "inflammatory alteration of the epithelium" were determined semi-quantitatively in semi-thin-secti ... | 1991 | 2068004 |
| helicobacter pylori in children. | the clinical manifestations of helicobacter pylori (formerly campylobacter pylori) infection in children overlap with those encountered in adults but there are some important differences. the aim of this review is to describe the range of manifestations of this infection in children, together with means of diagnosis and treatment. | 1991 | 2068024 |
| [the humoral and cellular immunity indices of patients with long-term nonhealing stomach ulcers with the presence of campylobacter pylori]. | the authors relate the data on humoral and cellular immunity in patients with long nonhealing gastric ulcers. it has been shown that if these patients have campylobacter pylori, there are no specific differences in the response of the immune system. during cicatrization, positive changes can be seen, namely an increase of t helper and decrease of suppressor activity of t lymphocytes together with a decline of the content of iga and igg. | 1991 | 2068663 |
| [helicobacter pylori in patho- and morphogenesis of chronic gastritis and peptic ulcer]. | review of the literature on the role of helicobacter pylori (hp) in the patho- and morphogenesis of chronic gastritis (cg) type b, gastric ulcer (gu) and duodenal ulcer (du) is presented. various hypotheses of pathogenetic effect of hp, histologic and ultrastructural characteristics of changes in the gastric and duodenal mucosa in hp infection are presented. the majority of authors consider hp as a possible pathogenic factor in cg type b, gu and du. however, there are works in which hp is regard ... | 1991 | 2069534 |
| helicobacter pylori, the bacterial cause of peptic ulcers and its potential impact on dental workers. | | 1991 | 2069765 |
| [helicobacter pylori and gastroduodenal pathology. first part: pathophysiology and diagnostic methods]. | | 1991 | 2070961 |
| [helicobacter pylori and gastroduodenal pathology. second part: clinical aspects and therapy]. | | 1991 | 2070962 |
| helicobacter pylori: aggressor or innocent bystander? | helicobacter pylori seeks gastric mucosa, whether found in the stomach, duodenum, or barrett's esophagus. definitive diagnosis can be secured by appropriate stains of mucosal biopsies and culture, but the rapid urease test, breath isotope studies, and serologic testing are also useful. the frequency of colonization increases with advancing age, but infection occurs earlier in underdeveloped countries. although the reservoir is uncertain, water or food transmission seems likely. there is sufficie ... | 1991 | 2072788 |
| peptic ulcer disease in children. | primary duodenal ulcer disease occurs in children of all ages, but is most often seen in those over 10 years. as in the adult, it often pursues a chronic course. primary gastric ulcer is seen in children under 6 years, is more unusual, and does not tend to recur. stress ulcers are seen most often in infants and in critically ill children and are asymptomatic until the complications of hemorrhage or perforation appear. drug-related ulcers are being seen more frequently as the use of nonsteroidal ... | 1991 | 2072794 |
| some perspectives on peptic ulcer. | in this article, the author comments on the following topics: whether peptic ulcer is a disease or just the sign of another process; whether the crater has a multifactorial origin; the ubiquity of helicobacter pylori and the conclusion that a specific strain will doubtless prove to be the cause of some, but not all, ulcers; the inherent definitional problem of "nonulcer dyspepsia"; and the controversy over how much gastric acid needs to be reduced to speed the healing of peptic ulcer. | 1991 | 2072797 |
| helicobacter pylori and gastric carcinoma. | a retrospective study was performed on gastric carcinomas to establish the prevalence of helicobacter pylori infection in gastric epithelium adjacent to the tumour. a total of 105 carcinomas were studied. the overall prevalence of helicobacter pylori infection was 59%. the prevalence in different age cohorts from patients with gastric carcinoma was compared with that in patients suffering from non-ulcer dyspepsia and, based on serological testing, with that in healthy blood donors. the presence ... | 1990 | 2076886 |
| [campylobacter pylori in gastroduodenal pathology]. | | 1990 | 2084340 |
| synergism between clindamycin and colloidal bismuth subcitrate against helicobacter (campylobacter) pylori in vitro. | a combination of clindamycin and colloidal bismuth subcitrate was evaluated for synergistic inhibition of helicobacter pylori employing the agar dilution method. a total of 47 clinical isolates of helicobacter pylori were examined. synergistic interaction was observed in 36%, additive behaviour in 64% of the strains. no antagonism could be detected. | 1990 | 2085373 |
| [enzyme-linked immunosorbent assay for the serodiagnosis of campylobacter pylori infection]. | antibody activities to campylobacter pylori in serum were estimated by an enzyme-linked immunosorbent assay (elisa) to crude antigens, prepared by sonication of whole organisms obtained from bacterial culture in 100 patients with chronic gastritis. significantly raised serum igg antibody activities to c. pylori was found in colonised patients with gastritis, especially in patients with active gastritis. high activities were also found beyond the age of 30. in 6 patients cleared of c. pylori with ... | 1990 | 2086012 |
| activity of cefixime against helicobacter pylori and affinities for the penicillin-binding proteins. | cefixime induced the formation of rounded cells from the spiral bacillary form of helicobacter pylori at the mic or less. three main penicillin-binding proteins, called a, b and c, were separated from h. pylori. cefixime had the strongest affinity to penicillin-binding protein b. the binding of cefixime to this protein may induce the formation of rounded h. pylori cells. | 1990 | 2088199 |
| [characteristics of helicobacter (campylobacter) pylori infection in our field]. | the presence of helicobacter pylori in the stomach in patients with clinical signs of gastroduodenal disease and its possible relationship with several clinical, endoscopic and anatomopathologic characteristics of the illness were prospectively evaluated in 359 patients. h. pylori was isolated from 388 samples in 216 patients (60% of colonization). in patients with endoscopic and, or, anatomopathologic evidence of gastroduodenal alterations the microorganism was isolated in 67% of the instances ... | 1990 | 2089203 |
| detection of helicobacter pylori in gastric brushings. | | 1990 | 2091356 |
| [t-lymphocytes of the gastric mucosa in peptic ulcer]. | chronic ulcer edges and pylorus of 6 stomachs removed because of ulcer and 10 biopsies of the stomach pylorus from patients with duodenal ulcer were studied. t-helpers and t-suppressors (cytotoxic) were revealed by the indirect three-step immunoperoxidase method with the use of monoclonal antibodies okt-4 and okt-8, respectively. t-suppressors (cytotoxic) prevailed among interepithelial gastric lymphocytes in both normal conditions and ulcer. t-helpers dominated in the mucosa tunica propria. the ... | 1990 | 2091578 |
| [detection of campylobacter pylori in gastric mucosa--relation to gastroscopy findings and degree of gastritis]. | in 862 unselected gastroscopies we could confirm the high percentage of campylobacter pylori infection in the antral gastric mucosa strongly associated with chronic superficial gastritis and active inflammatory signs. significant correlation with age concerned the normal findings only. in patients with duodenal ulcers we found in 91% gastritis and in 88% campylobacter pylori in antral mucosa. a small group with duodenal ulcers was campylobacter pylori-negative as well as without gastritis signs. ... | 1990 | 2091669 |
| comparison of four different methods for detection of helicobacter pylori from gastric biopsies. | helicobacter pylori are commonly found colonizing the gastric mucosa of different populations. its presence may be important in the pathogenesis of gastritis and peptic ulcer disease. the detection rates vary widely depending upon the diagnostic methods applied. in this study, multiple gastric biopsies were taken from the fundal and antral mucosa of 25 patients during endoscopy. in one patient, the procedure was repeated about two months after the initial biopsy. a total of 52 sets of specimens ... | 1990 | 2091902 |
| relative merits of various rapid biopsy urease tests for diagnosis of helicobacter pylori (campylobacter pylori). | three rapid urease tests, i.e., liquid urea broth containing phenol red as indicator, liquid urea broth containing bromothymol blue as indicator and clo gel were compared in 109 patients of dyspepsia for the diagnosis of campylobacter pylori (helicobacter pylori) infection. mean time taken for positive reaction in liquid broth with phenol was 3 minutes (range 0.6 to 5.3 minutes) with bromothymol blue was 3.5 minutes (range 0.4 to 5.5 minutes) while with clo gel it was 101 minutes (range 11-261 m ... | 1990 | 2092020 |
| unusual features of helicobacter (campylobacter) pylori--associated gastritis in india. a study of 200 cases. | helicobacter (campylobacter) pylori has been cultured from the antral biopsies of 85-90% of patients of gastritis, gastric ulcer and duodenal ulcer at different centres. studies conducted all over the world have firmly implicated this organism in the aetiology of active superficial gastritis and recurrences of duodenal ulcer. two hundred patients with upper abdominal pain, distension, vomiting and/or haemetemesis were subjected to ogd scopy. in 163 of these patients there was endoscopic evidence ... | 1990 | 2092022 |
| association of peptic ulcer with helicobacter pylori and the recurrence rate. a three year follow-up study. | helicobacter pylori is associated with 70-100% of peptic ulcers. relapse of infection has been shown to cause recurrences of ulcers in a large number of studies. we diagnosed 137 cases of peptic ulcer (121 du; 16 gu) during a 3 year period. of these, 117 were positive for h pylori. sixty six of the 117 cases staying in the vicinity of the hospital were followed up for a minimum period of 3 months upto a maximum period of 3 years. in 91 examinations there was relapse of h pylori infection and ulc ... | 1990 | 2092024 |
| relapse of helicobacter pylori infection after different treatment regimens. a 3-month follow-up study. | helicobacter pylori infection of gastric antrum is associated with a majority of cases of peptic ulcer (70-100%). studies have shown that when this organism is eradicated, the recurrence of ulcer falls to less than one-third of those in whom the infection persists or relapses. monotherapy with bismuth salts, tinidazone or amoxycillin has been shown to result in early relapse and recurrence of ulcers. however, dual or triple therapy regimens are more effective. we conducted a randomised controlle ... | 1990 | 2092026 |
| does helicobacter pylori play a role in the pathogenesis of peptic ulcer? part i: no. helicobacter pylori is a commensal in the stomach. | | 1990 | 2092033 |
| does helicobacter pylori play a role in the pathogenesis of peptic ulcer? part ii. yes, helicobacter pylori is a pathogenetic factor in peptic ulcer. | | 1990 | 2092034 |
| [biochemical, physiological, and enzymatic study of 78 strains of helicobacter (campylobacter) pylori isolated from gastroduodenal biopsies]. | a biochemical, physiological and enzymatic study of 78 c. pylori strains isolated from gastroduodenal biopsies is reported. all strains were positive in the oxidase, catalase and urease tests. 97.4% produced sh2 in the lead acetate band and 79.4% showed beta-hemolytic activity in sheep blood agar. in the antibiotic selection tests, c. pylori was characterized to be resistant to nalidixic acid and sensitive to cefalotin . the enzymatic study demonstrated the presence of acid and alkaline phosphat ... | 1990 | 2094388 |
| [comparative study of campylobacter pyloridis and campylobacter jejuni under electron microscope]. | specimens were made by preparing the ultrathin sections after negative staining and ruthenium red staining. the specimens were observed under electron microscope. results revealed that the shapes of campylobacter pyloridis (cp) and c. jejuni (cj) were similar, but distinctive differences in their structures were observed. cp had one to five sheathed flagella at one end with bulbous tips. cj had only one unsheathed flagellum on each end without a bulbous tip. the cell body of cp was longer than t ... | 1990 | 2094635 |
| [helicobacter pylori and gastro-duodenal pathology]. | helicobacter pylori (hp) were found in 878 (73%) of 1205 patients undergoing upper g-i endoscopy with multiple biopsies for gastroduodenal diseases. hp were present in similar percentages among patients with active (89%) or healed (81%) peptic ulcer as well as in non ulcerous dyspeptics affected with gastritis (85%). 96% of active chronic gastritis were infected by hp as compared with 55% of quiescent gastritis. antral gastritis was more frequently active in patients with ulcer diseases (76%) th ... | 1990 | 2094841 |
| eradication of campylobacter pylori and recurrence of duodenal ulcer. a six-month follow-up study. | fifty-four patients were studied, 41 men and 13 woman, aged 26-76 years, suffering from duodenal ulcer that healed 4-8 weeks after colloidal bismuth subcitrate therapy (360 mgr twice a day). all patients underwent endoscopy before treatment, 4-8 weeks and 6 months later. biopsy was taken for campylobacter pylori (c.p.) detection by urease test. all patients were c.p. positive initially. the organisms were eradicated in 36/54 patients (67%) at the end of therapy. ulcer healing was obtained after ... | 1990 | 2095099 |
| adherence of helicobacter pylori cells and their surface components to hela cell membranes. | four helicobacter pylori strains were used to develop in vitro methods to assess adherence to hela cells. using direct detection by microscopy, adhesion scores increased with the initial bacteria-to-cell ratio. the urease method assessed h. pylori bound to hela cells by their urease activity. the percentage of the original inoculum adhering to hela cells remained constant for initial ratios from 10(2) to 10(5) bacteria per cell. an elisa using anti-h. pylori serum assessed whole bacteria or comp ... | 1990 | 2097496 |
| helicobacter pylori--our knowledge is growing. | | 1990 | 2099416 |
| detection of helicobacter pylori from endoscopic biopsies and the biochemical characteristics of these isolates. | helicobacter pylori (formerly campylobacter pylori) has been recently described as a gastritis-associated bacterium. we examined endoscopic biopsies of 100 patients with dyspepsia and found h. pylori in the gastric antrum of 34 (34%) by either culture, urease tests and/or histology. thirty-one out of 41 patients (75.6%) confirmed to have chronic active gastritis histologically had h. pylori in their gastric antrum compared to 3 out of 59 patients (5.1%) with dyspepsia but normal histology (p les ... | 1990 | 2102969 |
| campylobacter pylori infection: experience in a multiracial population. | over a 15-month period, 399 patients with dyspepsia were investigated for the presence of campylobacter pylori infection. half of the patients (50.6%) had campylobacter organisms in the antrum of the stomach. c. pylori was found in 96.1% of patients with histological changes of chronic active gastritis in the antrum. of patients with duodenal and gastric ulcers, 87.8% and 87.5%, respectively, had campylobacter organisms, as did 39.3% of patients with non-ulcer dyspepsia. c. pylori infection was ... | 1990 | 2103410 |
| histological identification of helicobacter pylori in early and advanced gastric cancer. | | 1990 | 2103734 |
| gastric histology and plasma gastrin response to a meal in patients with duodenal ulcer disease after five years treatment with ranitidine. | fifty asymptomatic patients with duodenal ulcer disease, aged 31-82 years, who had received ranitidine maintenance therapy continuously for five or more years without a symptomatic recurrence, were studied. fasting plasma gastrin concentrations were normal (mean 24 pmol/l, s.d. +/- 22) while the post-prandial gastrin response was variable with maximum plasma concentrations ranging from 16 to 309 pmol/l. endoscopy revealed six asymptomatic peptic ulcers. histological examination of gastric biopsi ... | 1990 | 2103756 |
| dosage of colloidal bismuth subcitrate in duodenal ulcer healing and clearance of campylobacter pylori. | sixty consecutive patients with endoscopically proven duodenal ulcers were given colloidal bismuth subcitrate tablets either as 120 mg q.d.s. or 240 mg b.d., in a randomized single-blind study. the efficacy of each regimen was determined by endoscopic examination and antral biopsy at 4 weeks; if the ulcer remained unhealed, treatment was continued and endoscopy repeated at 8 weeks. the ulcer-healing efficacy of the two regimens was identical; however, in the four times daily group only 27% remai ... | 1990 | 2104073 |
| the interaction between helicobacter pylori culture filtrate and indomethacin: effects on the integrity of human gastric antral mucosa and its prostaglandin e2 production in vitro. | histopathological methods and radioimmunoassay were used to assess the microstructure and prostaglandin e2 production by paired specimens of human gastric antral mucosa; the specimens were studied after 48 h of incubation in base-line tissue culture medium, helicobacter pylori culture filtrate, h. pylori culture control fluid, indomethacin, and h. pylori culture filtrate plus indomethacin. when applied alone, the filtrate did not affect the structure of the mucosal tissue or its prostaglandin e2 ... | 1990 | 2104089 |
| [campylobacter (helicobacter) pylori-induced cost effectiveness-risk considerations]. | | 1990 | 2107370 |
| helicobacter pylori in gastroduodenal disease. | helicobacter pylori is a recently described gram-negative micro-organism, which plays an important role in the pathogenesis of peptic ulcer disease and gastritis. in this paper an outline is given of the history and the pathophysiology of helicobacter pylori, as well as the therapeutic studies aimed at eradication of the bacterium in various clinical entities. | 1990 | 2110652 |
| unsaturated fatty acids and viability of helicobacter (campylobacter) pylori. | helicobacter (campylobacter) pylori was found to be sensitive to the toxic effects of an unsaturated fatty acid (arachidonic acid). data are presented that support the hypothesis that exogenous catalase added to basal media enhances the growth of h. pylori by preventing the formation of toxic peroxidation products from long-chain unsaturated fatty acids. | 1990 | 2112559 |
| hydrophobic characterisation of helicobacter (campylobacter) pylori. | cell-surface hydrophobicity of helicobacter (formerly campylobacter) pylori was tested by aqueous two-phase partitioning and hydrophobic interaction chromatography. the hydrophobicity of h. pylori greatly exceeded that of campylobacter fetus subsp. fetus, c. jejuni and bacillus subtilis. a partition coefficient (pc) of hydrophobicity in the two-phase system was determined for h. pylori. pc was dependent on ph and the pc value was increased by greater than 20-fold at ph 2.5. lithium cations incre ... | 1990 | 2113100 |
| the 14co2 urea breath test for helicobacter pylori infection. | | 1990 | 2118567 |
| association of helicobacter pylori with acid peptic disease in karachi. | the prevalence of h. pylori infection in 200 dyspeptic patients undergoing upper g.i. endoscopy was investigated by histology and rapid urease test. h. pylori was associated with 86% cases of chronic gastritis, 84.6% cases of duodenal ulcers and 78.5% of gastric ulcers. none of the 15 histologically normal gastric biopsies showed h. pylori. | 1990 | 2123260 |
| helicobacter pylori induces lymphocyte activation in peripheral blood cultures. | helicobacter pylori-induced in vitro stimulation of mononuclear cells was characterized by measuring dna synthesis response, interferon-gamma (ifn-gamma) secretion and the number of immunoglobulin-secreting cells. the strength of these responses was measured in 51 subjects comprising 36 dyspeptic patients from the gastroenterological unit and 15 members of the laboratory staff. nineteen subjects had antibodies to h. pylori and 32 did not. the responses were compared with respect to h. pylori ant ... | 1990 | 2124957 |
| validation of a simplified carbon-14-urea breath test for routine use for detecting helicobacter [correction of heliobacter] pylori noninvasively. | a carbon-14 (14c) urea breath test for detecting helicobacter pylori with multiple breath sampling was developed. carbon-14-urea (110 kbq) administered orally to 18 normal subjects and to 82 patients with helicobacter infection. the exhaled 14c-labeled co2 was trapped at 10-min intervals for 90 min. the total 14c activity exhaled over 90 min was integrated and expressed in %activity of the total dose given. in normals, a mean of 0.59% +/- 0.24% was measured, resulting in an upper limit of normal ... | 1990 | 2125066 |
| a placebo controlled trial of bismuth salicylate in helicobacter pylori associated gastritis. | in a placebo controlled prospective clinical trial of bismuth salicylate in helicobacter pylori associated gastritis, 52 adult patients were randomly allocated to treatment with bismuth salicylate or placebo. helicobacter pylori were totally cleared in 77% patients in bismuth group but none in placebo group (p less than 0.001). resolution of gastritis (p less than 0.001) and improvement of symptoms (p less than 0.01) were significantly better in patients where h. pylori infection cleared as comp ... | 1990 | 2125658 |
| helicobacter pylori associated chronic gastritis and peptic ulceration in patients taking non-steroidal anti-inflammatory drugs. | helicobacter pylori is now recognized as a frequent cause of histological chronic gastritis, and this has radically changed our understanding of this common condition. in the light of these developments, the traditional view that non-steroidal anti-inflammatory drugs are one of the common 'environmental' causes of chronic gastritis has been re-examined. gastric mucosal biopsies have been studied from 430 patients undergoing routine upper gastrointestinal endoscopy, 99 of whom had recently been t ... | 1990 | 2129639 |
| helicobacter pylori infection treated with a tripotassium dicitrato bismuthate and metronidazole combination. | seventy-two patients with h. pylori infection in their antral mucosa took part in the study. forty-three received metronidazole 400 mg t.d.s. for two weeks, plus de-nol tabs 2 b.d. for four weeks, and the remaining 29 patients received metronidazole 400 mg t.d.s. for two weeks plus de-nol liquid 5 ml q.d.s. for four weeks. seven of 57 h. pylori isolates were found to have pre-treatment metronidazole resistance. success, in terms of eradication of h. pylori, was assessed using a one-month post-tr ... | 1990 | 2129652 |
| morphological study of the gastric antral mucosa colonized by campylobacter pylori. | antral biopsies from 56 patients who underwent gastroscopy for upper gastrointestinal symptoms were studied by transmission electron microscopy. campylobacter pylori was demonstrated in specimens from 39 patients. the bacteria were present in 3 of the 8 normal specimens and in 36 of the 48 cases with chronic gastritis. electron microscopy showed that organisms were located deep the mucous layer in intimate relation with the luminar surface of the antral epithelium. no ultra-structural evidence w ... | 1990 | 2131923 |
| helicobacter pylori and chronic antral erosions: our experience. | | 1990 | 2131932 |
| the influence of high blood levels of urea on the presence of campylobacter pylori in the stomach: a clinical study. | in order to determine whether urea influences the presence of campylobacter pylori (cp) in the stomach, the incidence of this infection was determined in patients with chronic renal failure who received no treatment (group a) or underwent regular hemodialysis (group b). a third group was examined as control. biopsies from the gastric antrum were taken for histological investigation and for cp detection. no significant differences among the 3 groups of patients were found with regards to the inci ... | 1990 | 2131933 |
| the first cases of helicobacter pylori (campylobacter pylori) reported from costa rica. | two gastric antrum biopsies of each of 92 consecutive patients undergoing gastroendoscopy were studied. the first biopsy was cultured for helicobacter (campylobacter) pylori. the second specimen was fixed and processed for histopathological analysis. the bacteria were isolated from 34 (81%) of 42 patients with nonspecific chronic gastritis, 19 (90%) of 21 cases of duodenal or gastric peptic ulcer, and from 3 (23%) of 13 normal patients. the overall frequency of isolation was 62 (67%) of the 92 c ... | 1990 | 2134727 |
| [histopathologic changes associated with the presence of helicobacter pylori in antral mucosa]. | helicobacter pylori is a gram negative bacteria which has recently been associated to tissular changes of the upper digestive tract, however, the causal role has not yet been determined. of 150 patients studied, 63 had tissular changes associated to helicobacter pylori (hp), 8 had hp without tissular related changes (of whom 3 suffered bulbar ulcus and 1 gastric ulcus); the rest of the patients had hiatus hernia associated to distal esophagitis or pyloric stenosis; and only one patient was found ... | 1990 | 2135572 |
| [clinical significance of helicobacter pylori]. | | 1990 | 2135580 |
| [can epigastric pain and non-ulcerative dyspepsia in children and adolescents be campylobacter pylori infection?]. | the authors examined 263 children and adolescents aged 5-20 years who suffered from so-called non-ulcerative dyspepsia or epigastric pain, because of the suspected presence of campylobacter pylori. in 31.9% of the examined subjects direct microbiological methods revealed its presence in the gastroduodenal mucosa. the confidence limit of positive results of campylobacter pylori in the population is between 27.58% and 38.84%, the probability being 95%. the authors proved a mutual correlation betwe ... | 1990 | 2136426 |
| [cytotoxic changes in cell cultures induced by newly isolated strains of campylobacter pylori]. | suspensions of primocultures of two strains of camplyobacter pylori, isolated from bioptic materials collected from patients with nodular hyperplasia of the pyloric antrum and with gastric ulcers were inoculated to 20-hour confluent or almost confluent cell cultures line vero, mccoy and ma 104 in test tubes and petri dishes. both strains of c. pylori adhered markedly to cell lines vero and mccoy and after 72 hours led to marked morphological changes of the cells. the changes were characterized i ... | 1990 | 2136427 |
| [determination of antibodies to campylobacter pylori in children and adolescents with gastroduodenal disorders]. | serological examination of antibodies against campylobacter pylori was made in 195 boys and girls aged 9-20 years. in all on account of gastrointestinal complaints endoscopy was indicated. the results of microbiological and histological finding), in particular in the antrum and corpus of the stomach). positive titres antrum and body of the stomach were compared with results of the complement fixation test and the elisa reaction. antibodies against c. pylori were detected in 64 of the examined su ... | 1990 | 2136428 |
| [campylobacter pylori--relation to gastric pathology and the effect of bismuth therapy]. | twenty-four patients with symptoms of gastric dyspepsia and active chronic gastritis in the antral mucosa were examined for the presence of campylobacter pylori before and after treatment with bismuth salts (12 patients) and antacids (12 patients). bismuth, contrary to the used antacid, significantly reduced the finding of c. pylori in the antral mucosa and had a favourable effect on the active form of chronic antral gastritis. | 1990 | 2136429 |
| [morphologic changes in chronic active superficial campylobacter pylori-positive antrum gastritis after treatment with bismuth]. | the authors investigated the effect of one month bismuth treatment (bismuthi citrici 120 mg per capsule), 4 x 120 mg/day, on morphological changes of the gastric mucosa along with the effect on campylobacter pylori (cp) in a group of 23 probands with histologically verified active superficial cp positive antrum gastritis. the probands suffered only from functional dyspepsia, to eliminate the action of other disease of the digestive tract on chronic gastritis. complete eradication of cp occurred ... | 1990 | 2136460 |
| [physiopathological basis for the treatment of peptic ulcer]. | peptic ulcer pathophysiology has advanced in several ways during the last years; the following facts has been put forward: a) there has been recognized specific receptors controlling oxyntic cell secretion for histamine, acetylcholine, gastrin and prostaglandins. agonists and antagonists for the above mentioned receptors has been synthesized. the physiology of the proton-pump located at the luminal side of the mucous membrane has been clarified. this pump is responsible for hcl secretion and can ... | 1990 | 2152274 |
| [the igg antibody response in patients colonized by helicobacter pylori]. | the igg antibody response specific to helicobacter pylori was evaluated through elisa in a group of 92 gastric patients colonized by this bacteria. 74 had gastritis and 19 gastroduodenal ulcer. three control groups were studied in a similar way: normal adult volunteers (n = 17), adults with e coli or s typhi bacteremia (n = 30) and normal infants (n = 30). igg antibody response to h pylori was demonstrated in 98% of colonized patients and 0% of infants. asymptomatic individuals and those with ba ... | 1990 | 2152642 |
| failure of azythromycin to eradicate campylobacter pylori from the stomach because of acquired resistance during treatment. | | 1990 | 2153337 |
| typing of campylobacter pylori by bacterial dna restriction endonuclease analysis and determination of plasmid profile. | campylobacter pylori isolates from 37 symptomatic patients and 3 asymptomatic volunteers were examined by chromosomal dna restriction endonuclease analysis and determination of plasmid profile. restriction digests with hindiii, haeiii, pvuii, and bglii produced clear and reproducible results that permitted discrimination between different strains. only 35% of c. pylori isolates were found to have plasmid dna. isolates from different patients, including those from two pairs of siblings, had uniqu ... | 1990 | 2153701 |
| is herpes simplex virus associated with peptic ulcer disease? | to test the hypothesis that herpes simplex virus type 1 (hsv-1) may be associated with peptic ulcer disease, we examined ulcerative lesions of the distal stomach and proximal duodenum for the presence of nucleic acids and antibodies specific for hsv-1. utilizing in situ hybridization, immunocytochemistry, and polymerase chain reaction with sequencing, gastric or duodenal tissues from 4 of 22 patients (18%) with documented peptic ulcer disease demonstrated the presence of both specific hsv-1 nucl ... | 1990 | 2157877 |
| increased tight junction width in two children with ménétrier's disease. | protein-losing enteropathy (ple) and edema are usually the most prominent clinical features in children with ménétrier's disease. however, the changes in gastrointestinal mucosa that can cause ple have not been described yet in children. we studied by electron microscopy the mucosa of the gastric fundus, which is the site where macroscopic changes are most prominent, in two children with ménétrier's disease. we found that tight junction width was increased to 10.5 +/- 0.94 nm (mean +/- 1 sd) in ... | 1990 | 2167358 |
| signature patterns of dna restriction fragments of helicobacter pylori before and after treatment. | the genomic dna of helicobacter pylori was studied by electrophoretic analysis of restriction endonuclease fragments. twenty seven isolates from eight patients in the united kingdom, obtained before and after treatment with nitrofurantoin, and two reference strains from australia and peru were investigated. digestion of dna with haeiii, which gave the clearest band pattern of the 20 enzymes tested, showed that each set of isolates from a single patient had a unique band pattern. the dna signatur ... | 1990 | 2169483 |
| possible role of leukotrienes in gastritis associated with campylobacter pylori. | this study was done to evaluate the role of leukotrienes (lts) in gastritis associated with campylobacter pylori. biopsy specimens of gastric mucosa were obtained endoscopically from 18 patients with nonulcer dyspepsia for bacteriological and histological examination and extraction of lts. there was correlation between the ltb4 level in the mucosa and the degree of gastritis evaluated histologically. the level was higher when infiltration of neutrophils in the gastric mucosa was more extensive. ... | 1990 | 2170499 |
| comparison of anti-helicobacter (campylobacter) pylori igg antibodies between different areas of belgium. | we have collected sera from 4053 patients of different parts of belgium. sera were randomly selected whatever the kind of pathology. anti-helicobacter (campylobacter) pylori igg were determined with an elisa technique using whole formalized bacteria. the results suggest that the mean antibody titres differ between various areas, with an overall higher prevalence in the north-western part of the country. | 1990 | 2173316 |
| drug therapy for helicobacter pylori infection: problems and pitfalls. | antibacterial chemotherapy against helicobacter pylori is currently being assessed by open or randomized controlled clinical studies for its efficacy in eradicating this bacterium from the stomach of patients with gastritis or gastroduodenal ulcer. whereas there is presently no "optimal" agent and treatment scheme, the combination of some antibiotics (metronidazole, tinidazole, amoxicillin) with bismuth salts proves definitely superior in vivo to either of these agents administered alone. severa ... | 1990 | 2174642 |
| comparison of different tests for helicobacter pylori. | | 1990 | 2178404 |
| helicobacter pylori: controversies and an approach to management. | helicobacter pylori (formerly, campylobacter pylori) is a gram-negative, spiral-shaped bacterium with a strong affinity for gastric-type epithelium. convincing evidence indicates that h. pylori plays an etiologic role in the development of chronic, nonspecific gastritis, and it may play an important role in the pathogenesis of duodenal ulcer disease. an etiologic role for this organism in chronic gastric ulceration, nonulcer dyspepsia, and gastric carcinoma is not established. whereas the diagno ... | 1990 | 2179647 |
| rapid urease tests for campylobacter pylori. | | 1990 | 2180988 |
| helicobacter pylori and the pathogenesis of gastroduodenal inflammation. | helicobacter pylori is a newly discovered gram-negative bacterium that lives in the human stomach and duodenum. infection with this organism is strongly associated with type b antral gastritis and with peptic ulcer disease. recent evidence from human volunteer studies, therapeutic trials with antimicrobial agents, and experiments with animal models indicates that h. pylori plays an etiologic role in the pathogenesis of type b gastritis. gastric metaplasia is observed in virtually all patients wi ... | 1990 | 2181029 |
| identification of campylobacter pylori in gastric biopsy smears. | the use of gastric biopsy imprint smears to diagnose campylobacter pylori was compared with the use of tissue sections and cultures. multiple gastric biopsies were taken from the mucosa of 42 patients during endoscopy. imprint smears were prepared from the samples used to make tissue sections; other samples were used for microbiologic culture. there was a good concordance (93%) between the morphologic diagnosis of c pylori in the air-dried, giemsa-stained smears and the tissue sections; the cyto ... | 1990 | 2181802 |
| evaluation of a selective enrichment technique for the isolation of campylobacter pylori. | to cultivate campylobacter pylori from contaminated biopsy specimens, brucella broth was supplemented with 10% fetal calf serum, 1% vitox, 1000 units/ml polymyxin b sulfate, 10 micrograms/ml vancomycin, and 2 micrograms/ml amphotericin b. pseudomonas aeruginosa, candida albicans, and enterococcus fecalis were cocultivated with c. pylori. all four strains of c. pylori were recoverable at 24 h. when 21 c. pylori strains were studied in pure culture, 86% grew in the selective enrichment medium. in ... | 1990 | 2182378 |
| campylobacter pylori: a new pathogen. | there is now considerable evidence suggesting that c. pylori is a human pathogen. the strong association between c. pylori and gastroduodenal disease is well documented. a number of hypotheses have been suggested for the pathogenic mechanisms of c. pylori-induced gastroduodenal disease, including the production of cytotoxins and the mechanical disruption of the epithelium. at the present time, treatment with a combination of antimicrobial agents eradicates the infection in approximately 50% of c ... | 1990 | 2183821 |
| campylobacter pylori and its role in peptic ulcer disease. | in almost all patients with genuine nondrug-induced duodenal or gastric ulcer there is evidence of gastric campylobacter pylori colonization and concomitant inflammation. c. pylori is only demonstrable in the duodenal cap when there is "gastric mucus metaplasia." suppression or eradication of c. pylori with antibiotic therapy may accelerate duodenal ulcer healing. the relapse rate of duodenal ulcer is less after temporary clearing or permanent eradication of c. pylori. as eradication of c. pylor ... | 1990 | 2184128 |
| [campylobacter pylori-helicobacter pylori. a long development]. | | 1990 | 2184426 |
| campylobacter (helicobacter) pylori. is peptic disease a bacterial infection? | | 1990 | 2184791 |
| purification and characterization of urease from helicobacter pylori. | urease was purified 112-fold to homogeneity from the microaerophilic human gastric bacterium, helicobacter pylori. the urease isolation procedure included a water extraction step, size exclusion chromatography, and anion exchange chromatography. the purified enzyme exhibited a km of 0.3 +/- 0.1 mm and a vmax of 1,100 +/- 200 mumols of urea hydrolyzed/min/mg of protein at 22 degrees c in 31 mm tris-hcl, ph 8.0. the isoelectric point was 5.99 +/- 0.03. molecular mass estimated for the native enzym ... | 1990 | 2188975 |
| [campylobacter pylori and its role in the etiopathogenesis of upper digestive tract diseases]. | | 1990 | 2192401 |
| [helicobacter pylori and gastric pathology]. | | 1990 | 2193600 |
| [does helicobacter pylori have a direct proteolytic effect in ulcerative disease?]. | helicobacter pylori (h.p.), has been shown, experimentally, to exert a proteolytic activity against mucous fractions. aim of this study was to assess the prevalence of h.p. in peptic ulcer and to analyze its possible influence on gastric mucus components, on peptic activity in gastric juice and the possible action on peptic secretion. 223 patients undergoing upper gastrointestinal endoscopy were analyzed for the presence of h.p. in the mucosa: 99 duodenal ulcer patients (d.u.), 58 gastric ulcer ... | 1990 | 2194877 |
| gastritis in the elderly. | the elderly have an increased prevalence of gastritis and the complications associated with it. the two major classes of acute and chronic gastritis, type a and b, are discussed as they relate to clinical findings, histologic features, and pathogenesis. an age-related increase in the frequency of helicobacter pylori (formerly campylobacter pylori) infection in the elderly parallels the known age-related increase in the prevalence of gastritis. the close association between gastritis in the elder ... | 1990 | 2194946 |
| helicobacter pylori (formerly campylobacter pyloridis/pylori) 1986-1989: a review. | | 1990 | 2196282 |
| a simple method to detect helicobacter pylori in gastric specimens. | | 1990 | 2196955 |
| bismuth therapy in gastrointestinal diseases. | bismuth therapy has shown efficacy against two major gastrointestinal disorders: peptic ulcer disease and diarrhea. in peptic ulcer disease it is as effective as the h2-receptor antagonists, costs considerably less, and offers a lower rate of relapse. when helicobacter pylori is implicated, bismuth acts as an antimicrobial agent, suppressing the organism but not eliminating it. in recent studies, bismuth compounds have been used with conventional antibiotics, producing elimination of the organis ... | 1990 | 2199292 |
| campylobacter pylori. a new era in gastroduodenal disorders? | | 1990 | 2199425 |