| application of portable ultrasound scanners in the measurement of post-void residual urine. | the aims of the present study were to investigate the impact of research subjects' characteristics on the accuracy of the bladderscan when the latter is used to measure post-void residual urine volume, and to evaluate differences between bladderscan and catheterization in terms of the expenditure of time and of human and material resources. subjects in the present study were 71 patients undergoing inpatient or outpatient rehabilitation therapy. post-void residual urine was measured with the blad ... | 2005 | 16237633 |
| primary lymphoepithelioma-like carcinoma of minor salivary gland: a case report with immunohistochemical and in situ hybridization studies. | lymphoepithelioma-like carcinomas (lec) of salivary glands represent rare epithelial malignancies, with most cases affecting the parotid gland. to our knowledge, there was only one lec arising from the minor salivary gland described in the english-language literature. | 2006 | 16240326 |
| homozygous deletion genotype of angiotensin converting enzyme confers protection against migraine in man. | studies have shown that migraine may have a major genetic component. meanwhile, angiotensin converting enzyme (ace) gene has been implicated as a genetic factor associated with migraine. we designed a case-control study to investigate the association between ace and migraine in 240 migraine patients and 200 healthy controls, matched by age and sex. there was no significant difference in allelic frequency (i and d) and genotype polymorphism (dd, di and ii) of the ace gene in migraine patients and ... | 2005 | 16252613 |
| cytotoxic phenylpropanoid glycosides from the stems of smilax china. | bioassay-guided fractionation of an ethanol extract of smilax china led to the isolation of nine phenylpropanoids including six new compounds, smilasides a-f (1-6), and three known phenylpropanoids, smiglaside e, heloniosides b, and 2',6'-diacetyl-3,6-diferuloylsucrose. structural elucidation of isolates 1-6 was based on spectroscopic data analysis. these new phenylpropanoids were evaluated against several human tumor cell lines. | 2005 | 16252910 |
| high prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in south taiwan. | we attempted to determine the prevalence of genital human papillomavirus (hpv) infection in women attending gynecologic practitioners in south taiwan. | 2006 | 16256180 |
| the lrrk2 i2012t, g2019s, and i2020t mutations are rare in taiwanese patients with sporadic parkinson's disease. | | 2005 | 16256409 |
| prevalence of cervical human papillomavirus in taiwanese women. | to define the prevalence rate of cervical human papilloma virus (hpv) using dna oligonucleotide microarray and its correlation with risk factors in taiwanese women in metropolitan taipei. | 2005 | 16265998 |
| taiwankadsurins a, b, and c, three new c19 homolignans from kadsura philippinensis. | [structures: see text] three novel c19 homolignans, designated taiwankadsurins a (1), b (2), and c (3), were isolated from the aerial parts of taiwanese medicinal plant kadsura philippinensis. the structures of 1-3, which have a 3,4-{1'-[(z)-2''-methoxy-2''-oxo-ethylidene]}-pentano(2,3-dihydro-benzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton, were determined by spectroscopic analyses, especially 2d nmr techniques (hmbc and noesy). compound 2 exhibited mild cytotoxic ... | 2005 | 16268562 |
| cystic fibrosis with homozygous r553x mutation in a taiwanese child. | it has been reported that cystic fibrosis is very rare in asians, and its clinical expression and genetic mutations are different from those found in caucasians. we report the case of a boy who had chronic diarrhea with failure to thrive and frequent respiratory tract infections beginning at the age of 2 months. he developed bronchiectasis with chronic severe hypoxemia and pancreatic insufficiency by the age of 3 years and 5 months, which raised the consideration of cystic fibrosis. dna analysis ... | 2005 | 16283068 |
| association of genetic polymorphisms of mk, il-4, p16, p21, p53 genes and human gastric cancer in taiwan. | to assess gastric cancer risk and clinical-pathological factors associated with genetic polymorphisms of mk, il-4, p16, p21 and p53 genes. | 2005 | 16289646 |
| probabilistic risk assessment for personal exposure to carcinogenic polycyclic aromatic hydrocarbons in taiwanese temples. | to assess how the human exposure to airborne carcinogenic polycyclic aromatic hydrocarbons (pahs) during working in or visiting a typical taiwanese temple, we present a probabilistic risk model, appraised with reported empirical data. two approaches are applied, one based on animal-derived benzo[a]pyrene (b[a]p) toxic equivalents (b[a]p(eq)) of individual pahs and one is assumed that the potency of pah mixtures is linked to their b[a]p level. the model integrates probabilistic exposure profiles ... | 2006 | 16293284 |
| a probabilistic transmission dynamic model to assess indoor airborne infection risks. | the purpose of this article is to quantify the public health risk associated with inhalation of indoor airborne infection based on a probabilistic transmission dynamic modeling approach. we used the wells-riley mathematical model to estimate (1) the co2 exposure concentrations in indoor environments where cases of inhalation airborne infection occurred based on reported epidemiological data and epidemic curves for influenza and severe acute respiratory syndrome (sars), (2) the basic reproductive ... | 2005 | 16297217 |
| functional assays of hla a2-restricted epitope variant of latent membrane protein 1 (lmp-1) of epstein-barr virus in nasopharyngeal carcinoma of southern china and taiwan. | human leukocyte antigen (hla) a2 was consistently associated with increased risk for nasopharyngeal carcinoma (npc) in chinese populations. previously we have reported that an epstein-barr virus (ebv) strain carrying an hla a2-restricted epitope variant of lmp-1 is prevalent in npc in southern china and taiwan (lin et al., j. gen. virol. 85: 2023-2034, 2004). the variant has mutation selectively involved one of the two anchor residues in position 2 (125 l-->f) and an additional mutation in posit ... | 2005 | 16307312 |
| cytotoxic clerodane diterpenoids from casearia membranacea. | bioassay-guided fractionation of the etoac extract of casearia membranacea leaves and twigs afforded three new clerodane diterpenes, caseamembrins m-o (1-3), and the known rel-(2s,5r,6r,8s,9s,10r,18s,19r)-2-(2-methylbutyryloxy)-6-hydroxy-18,19-di-o-acetyl-18,19-epoxycleroda-3,13(16),14-triene (4) and caseamembrin d (5). the structures of 1-3, including the relative configurations, were established by extensive nmr spectroscopic analyses. the cytotoxic activities of the isolated diterpenoids agai ... | 2005 | 16309320 |
| immunosuppressive iridoids from the fruits of gardenia jasminoides. | a new iridoid, gardaloside (1), and a new safranal-type monoterpene, jasminoside g (2), together with 10 known compounds including nine iridoids and a second safranal-type monoterpene, were isolated from the fruits of gardenia jasminoides. the structures of 1 and 2 were established on the basis of spectroscopic evidence. of these compounds, geniposide (3), 6alpha-hydroxygeniposide (5), ixoroside (7), and shanzhiside (8) showed significant inhibition of il-2 secretion by phorbol myristate acetate ... | 2005 | 16309325 |
| cytotoxic prenylflavonoids from artocarpus elasticus. | five new prenylated flavonoids, artelastoheterol (1), artelasticinol (2), cycloartelastoxanthone (3), artelastoxanthone (4), and cycloartelastoxanthendiol (5), along with five known compounds, were isolated from the root bark of artocarpus elasticus. the structures of 1-5 were elucidated by spectroscopic methods and through comparison with data reported in the literature. the previously known compound artonol a (6) exhibited cytotoxic activity against the a549 human cancer cell line, with an ed5 ... | 2005 | 16309328 |
| detection of rhd(el) in rhd-negative persons in clinical laboratory. | the rhesus (rh) blood group is the most polymorphic human blood group system, and it is clinically significant in transfusion medicine. about 15% of caucasoid people are rhd-negative, whereas in the asian population, the rhd-negative blood type only occurs in 0.1% to 0.5%. however, approximately 30% of apparently rhd-negative taiwanese people actually were rhd(el). traditionally, we verify rhd(el) by a serologically adsorption-elution procedure with polyclonal anti-d. in our recent report, rhc p ... | 2005 | 16310514 |
| pulsed-field gel electrophoresis, plasmid profiles and phage types for the human isolates of salmonella enterica serovar enteritidis obtained over 13 years in taiwan. | plasmid profile, phage typing, and pulsed-field gel electrophoresis (pfge) patterns of 124 salmonella enteritidis strains isolated in 1998-2002 in taiwan were analysed and the results were compared with those of the 63 strains obtained in 1991-1997, so that molecular subtypes and epidemic strains for salmonella enteritidis over a 13-year period (1991-2002) could be elucidated. | 2005 | 16313420 |
| aberrant promoter methylation of ednrb in lung cancer in taiwan. | hypermethylation has been shown in the promoter region of the endothelin receptor b (ednrb) gene in several human tumors, but its role in lung cancer formation is unclear. in this study, genomic dna from lung cancer patients was subjected to methylation-specific pcr to determine the methylation status of the ednrb gene in lung cancer. aberrant methylation of the ednrb gene was detected in 32.9% (26 of 79) lung cancer patients. promoter hypermethylation of ednrb was found to significantly differ ... | 2006 | 16328051 |
| the hogg1 ser326cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance. | increased oxidative stress has been observed to contribute the development of insulin resistance. oxidative stress is known to increase the conversion of deoxyguanosine (dg) to 8-hydroxy-2'-deoxyguanosine (8-ohdg). human 8-oxoguanine glycosylase (hogg1) is the key component responsible for the removal of 8-ohdg from oxidatively damaged dna. the repair activity of the hogg1 ser326cys gene variant has been demonstrated to be lower than that of the hogg1 ser/ser genotype. therefore, the possible as ... | 2006 | 16333523 |
| atmospheric polycyclic aromatic hydrocarbons (pahs) in asia: a review from 1999 to 2004. | polycyclic aromatic hydrocarbons (pahs) are present in both gaseous and particulate phases. these compounds are considered to be atmospheric contaminants and are human carcinogens. many studies have monitored atmospheric particulate and gaseous phases of pah in asia over the past 5 years. this work compares and discusses different sample collection, pretreatment and analytical methods. the main pah sources are traffic exhausts (acpy, fl, flu, pa, pyr, chr, bep) and industrial emissions (bap, baa ... | 2006 | 16343719 |
| novel deletion mutations of the dax1 (nr0b1) gene in two taiwanese families with x-linked adrenal hypoplasia congenita. | to analyze the dax1 (nrob1) gene in taiwanese families with adrenal hypoplasia congenita. | 2005 | 16355812 |
| replication of association of il1 gene complex members with ankylosing spondylitis in taiwanese chinese. | to test the association of interleukin 1 (il1) gene family members with ankylosing spondylitis (as), previously reported in europid subjects, in an ethnically remote population. | 2006 | 16361275 |
| lack of association between infection with a novel human coronavirus (hcov), hcov-nh, and kawasaki disease in taiwan. | we investigated whether infection with a novel human coronavirus (hcov), called "new haven coronavirus" (hcov-nh)--which is similar to and likely represents the same species as another novel hcov, hcov-nl63--is associated with kawasaki disease (kd) in taiwan. fifty-three patients with kd were enrolled in our study. serum, peripheral-blood mononuclear cells, nasopharyngeal aspirates, throat swabs, and rectal swabs from these patients were assayed for hcov-nl63 by real-time reverse-transcriptase ( ... | 2006 | 16362893 |
| taiwan: aids ngos fight to keep human rights law. | thirty-seven government deputies, all members of the ruling democratic progress party (dpp), have recently proposed a bill to eliminate article 6-1 of taiwan's aids prevention and control act (1997). | 2005 | 16365972 |
| new insights into the pathological mechanisms of cerebrotendinous xanthomatosis in the taiwanese using genomic and proteomic tools. | cerebrotendinous xanthomatosis (ctx) is an autosomal recessive lipid-storage disorder caused by a deficiency of the mitochondrial sterol 27-hydroxylase. genetic analysis utilizing sscp and direct dna sequencing identified a new mutation. one base-pair of cytosine was deleted at codon 326 on exon 2 of cyp27 in all ctx patients while their father was heterozygotic. this novel point deletion predicts a frameshift in mrna (pro(102) -->leu) and results in the appearance of a premature termination cod ... | 2006 | 16372260 |
| development of a framework for sustainable uses of resources: more paper and less plastics? | taiwan's epa has implemented a new guideline called the "plastic products restriction policy", prohibiting some industries to use plastics as packaging materials for the sake of sustainable use of resources. the significant effect resulting from this policy is the substitution of plastic products with paper products. is this policy beneficial to achieve future sustainability? i attempt to analyze the resource choice between renewable resources and exhaustible resources for production of final pr ... | 2006 | 16380163 |
| identification of ocrl1 mutations in two taiwanese lowe syndrome patients. | the oculocerebrorenal syndrome of lowe (ocrl) is a rare x-linked multisystem disorder characterized by congenital cataracts, mental retardation, and renal tubular dysfunction. the ocrl1 gene responsible for lowe syndrome has been mapped to chromosome xq24-q26. we analyzed two taiwanese ocrl patients and their families. in case 1, a splicing mutation (889-11 g --> a) was identified in intron 10 of the ocrl1 gene. the mother is a heterozygous carrier. the 889-11 g --> a mutation results in an abno ... | 2005 | 16381338 |
| no alcoholism-protection effects of adh1b*2 allele in antisocial alcoholics among han chinese in taiwan. | suggested that the genetic variation at adh1b and aldh2 influences the risk of alcoholism. the adh1b*2 and aldh2*2 alleles had been thought to be protective against alcoholism. recent studies have suggested that either physiological tolerance of blood acetaldehyde, or innate insensitivity to it, or both may play a crucial role in keeping alcoholism from developing by protecting against adverse reactions. aldh inactive form resulting from aldh2*2, which slows the elimination of acetaldehyde and t ... | 2005 | 16385179 |
| risk of oral nonmalignant lesions associated with human papillomavirus infection, betel quid chewing, and cigarette smoking in taiwan: an integrated molecular and epidemiologic study. | in contrast to previous studies about the association of oral squamous cell carcinoma with human papillomavirus (hpv) 16/18, the associations between nonmalignant oral lesions (chronic inflammation, submucous fibrosis, leukoplakia, and squamous papilloma) and hpv are much less well understood. | 2006 | 16390239 |
| absence of significant associations between four akt1 snp markers and schizophrenia in the taiwanese population. | akt1 (v-akt murine thymoma viral oncogene homolog 1) is a protein kinase isoform of akt. five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of akt1 have been reported to be significantly associated with schizophrenia. we tested for the presence of these five single-nucleotide polymorphisms in a taiwanese population by genotyping 218 co-affected schizophrenia families. both single locus and haplotypes analyses showed no associatio ... | 2006 | 16395129 |
| effect of the mother's consumption of traditional chinese herbs on estimated infant daily intake of lead from breast milk. | infant exposure to lead through breast milk is of special concern because breast milk is considered the best food source for infants under 6 months. in this study, a total of the mothers provided colostrum samples once in the early postpartum period, but only 16 of them provided breast milk weekly at 1-60 days postpartum. the geometric mean of lead concentrations in all colostrum samples (n=72) was 7.68+/-8.24 microg/l. the concentration of lead in the breast milk of the consumption group (the m ... | 2006 | 16398988 |
| interaction of the g182c polymorphism in the apoa5 gene and fasting plasma glucose on plasma triglycerides in type 2 diabetic subjects. | apolipoprotein av (apoa5) is an important determinant of plasma triglyceride concentration. this study aimed to investigate the relationship of an amino acid substitution at position 182 (g182c) of the apolipoprotein av (apoa5) gene with triglyceride concentration in a taiwanese population. | 2005 | 16401313 |
| interactive effects between cyp1a1 genotypes and environmental polychlorinated dibenzo-p-dioxins and dibenzofurans exposures on liver function profile. | previous studies reported that polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdd/fs) induced hepatic cytochrome p-4501a1 (cyp1a1). the aim of this study was to examine the interactive influence of cyp1a1 genotypes and pcdd/fs exposure on liver function profile. pcdd/fs levels and liver function parameters were determined in serum and correlated with genetic polymorphism of cyp1a1/msp 1 in 225 human volunteers who had no or minimal occupational exposure to pcdd/f. the results showed that ... | 2006 | 16407087 |
| localization of a susceptibility locus for hepatocellular carcinoma to chromosome 4q in a hepatitis b hyperendemic area. | chromosome 4q is one of the most common regions with a high frequency of allelic loss in hepatocellular carcinoma (hcc). to identify the hcc-susceptibility locus on chromosome 4q, we have performed linkage and family-based association analyses on chinese families with hcc from taiwan, where hepatitis b is hyperendemic. using 77 microsatellite markers spanning chromosome 4q on 52 multiplex families, we found suggestive evidence of linkage to 4q22.3-28.1 with a maximum two-point heterogeneity lod ... | 2006 | 16407824 |
| biochemistry examinations and health disorder evaluation of taiwanese living near incinerators and with low serum pcdd/fs levels. | the main objective of this study was to establish background levels of serum pcdd/fs and biochemistry of residents living near municipal waste incinerators (mwis) which had been operating between 1 and 8 years, and also to examine the association between the serum pcdd/fs levels and health outcomes of interest. information on medical history, life-style, and dietary habits was obtained by questionnaire interview. significantly elevated levels of glucose and blood urea nitrogen (bun) were found i ... | 2006 | 16412497 |
| cyp2c9 polymorphism and warfarin sensitivity in taiwan chinese. | warfarin prevents thromboembolism in patients with prosthetic heart valvular replacement. cytochrome p4502c9 (cyp2c9) is polymorphic in human and is principally responsible for the metabolism of warfarin. however, known cyp2c9 polymorphisms cannot entirely account for the low dose requirement of warfarin in chinese-taiwanese receiving mitral valve replacement. we screened a new polymorphism of cyp2c9 and investigated its role in warfarin sensitivity. | 2006 | 16413010 |
| the influence of biologic factors on the surgical decision in advanced neuroblastoma. | molecular markers greatly affect the outcome of neuroblastoma. this study evaluated the influence of trk-a and myelocytomatosis viral-related oncogene, neuroblastoma-derived (mycn) on the role of surgery in advanced neuroblastoma. | 2006 | 16418884 |
| a pilot study of a new thrombolytic agent for acute ischemic stroke in taiwan within a five-hour window. | this study was the first clinical trial in taiwan of a new thrombolytic agent human tissue urokinase type plasminogen activator (htupa) in patients with acute ischemic stroke. | 2006 | 16424373 |
| human thelaziasis occurrence in taiwan. | a 62-year-old woman presented with unilateral eye swelling and itching. subsequent examination showed the cause was an infestation of the parasitic worm thelazia callipaeda. the vector leading to human infection is the fly. the possible mechanisms of infection for this patient are discussed. although this is a known form of ocular infection, especially in asia, this is one of few reported cases in taiwan. | 2006 | 16430440 |
| in-depth investigation of escalator riding accidents in heavy capacity mrt stations. | in 2000, the accident rate for escalator riding was about 0.815 accidents per million passenger trips through taipei metro rapid transit (mrt) heavy capacity stations. in order to reduce the probability and severity of escalator riding accidents and enhance the safety of passengers, the drury and brill model [drury, c.g., brill, m., 1983. human factors in consumer product accident investigation. hum. factors 25 (3), 329-342] for in-depth investigation was adopted to analyze the 194 escalator rid ... | 2006 | 16434013 |
| patterns of genetic variation in the hypertension candidate gene grk4: ethnic variation and haplotype structure. | association studies using single nucleotide polymorphisms (snps) have the potential to help unravel the genetic basis of hypertension. nevertheless, to date, association studies of hypertension have yielded ambiguous results. it is becoming clear that such association studies must be interpreted within the context of the genetic structure of the populations being studied, and patterns of variation within specific genomic regions. with this in mind we analyzed genetic variation in the g protein-c ... | 2006 | 16441255 |
| epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in taiwan in 2003. | taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (sars) infections in 2003. two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe sars infections to help us investigate epidemiological and genetic factors associated with the sars coronavirus (sars-cov). sars-cov infections were detected by using enzyme immunoassays and confirmed by a combination of western blot assays, neutralizing antibod ... | 2006 | 16455884 |
| the cblb gene and graves' disease in children. | the cblb gene functions as a negative regulator of autoimmunity. impairment of the cbl-b signaling pathway may contribute to human autoimmune disease. dbsnp rs2305035 is a c/t polymorphism located in exon 10 of the cblb gene. we report an association study of this polymorphism in children with graves' disease. the patients were 158 unrelated children (125 girls) with graves' disease, aged 9.8 +/- 3.3 years. the controls consisted of 237 adults without a history of autoimmune disease. the c allel ... | 2005 | 16459459 |
| first thelazia callipaeda infestation report in a dog in taiwan. | an ocular thelazia callipaeda infestation was found in a male domestic dog in taiwan during regular examination. this is the first report of the parasite from pet animal in taiwan. the infested dog showed normal bodily condition but slight conjunctival congestion. this parasite has been reported in humans in southeast asia, china and korea. in 1998, first human case was reported in the central area of taiwan. the dogs infected with t. callipaeda may have important implication in the infestation ... | 2006 | 16462129 |
| genetic diversity of noroviruses in taiwan between november 2004 and march 2005. | noroviruses are a major health burden and are responsible for the majority of outbreaks of gastroenteritis in the world. human noroviruses can be genetically divided into two main genogroups (gi and gii) and subdivided into many genotypes. in this study, stool specimens collected from 12 outbreaks of gastroenteritis in taiwan were screened for viral agents between the 23rd of november 2004 and 9th of march 2005. noroviruses were detected in all outbreaks. we detected six different norovirus geno ... | 2006 | 16463123 |
| mutation analysis of crouzon syndrome in taiwanese patients. | crouzon syndrome is an autosomal-dominant disorder that causes premature fusion of the cranial suture. crouzon, pfeiffer, and apert syndromes are caused by mutations in the extracellular, third immunoglobulin-like domain, and adjacent linker regions (exons iiia and iiic) of the fibroblast growth factor receptor 2 (fgfr2) gene. we screened 12 crouzon syndrome patients for mutations in exons iiia and iiic of the fgfr2 gene by polymerase chain reaction (pcr) and direct sequencing. mutations were de ... | 2006 | 16470531 |
| a novel heterozygous missense mutation 377t > c (v126a) of tgif gene in a family segregated with holoprosencephaly and moyamoya disease. | to identify whether any mutations of candidate genes including shh, zic2, six3, and tgif exist in a taiwanese family segregated with holoprosencephaly (hpe) and moyamoya disease. | 2006 | 16475235 |
| work stress among nursing home care attendants in taiwan: a questionnaire survey. | care attendants constitute the main workforce in nursing homes, but their heavy workload, low autonomy, and indefinite responsibility result in high levels of stress and may affect quality of care. however, few studies have focused of this problem. | 2007 | 16476432 |
| detection of hunter syndrome (mucopolysaccharidosis type ii) in taiwanese: biochemical and linkage studies of the iduronate-2-sulfatase gene defects in mps ii patients and carriers. | hunter syndrome (mucopolysaccharidosis type ii) is an x-linked recessive lysosomal storage disease caused by a defect of the iduronate-2-sulfatase (ids) gene. the result is impaired ids enzyme function. | 2006 | 16480701 |
| impact of a short-term community-based cleanliness campaign on the sources of dengue vectors: an entomological and human behavior study. | in june 2002, a considerable number of cases of dengue fever/dengue hemorrhage fever were reported in south taiwan. to effectively reduce the sources of dengue vectors, the government conducted a weeklong community-based cleanliness campaign. the study reported here was designed to evaluate the effectiveness of the campaign. the sources of dengue vectors were evaluated according to changes in the ovitrap index. this index significantly decreased from 66.7 percent before the campaign to 39.3 perc ... | 2006 | 16483083 |
| uniform deletion junctions of complete azoospermia factor region c deletion in infertile men in taiwan. | to determine the deletion junctions of infertile men in taiwan with azoospermia factor region c (azfc) deletions and to evaluate the genotype/phenotype correlation. | 2006 | 16491273 |
| cespitulactones a and b, new diterpenoids from cespitularia taeniata. | two new diterpenoids, designated cespitulactones a (1) and b (2), were isolated from a sample of the soft coral cespitularia taeniata collected in taiwan. compound 1 possesses a novel structure with a bond cleavage between c-10 and c-11, and having a 14-membered lactone ring junction between c-10 and c-12. their structures were elucidated on the basis of extensive spectroscopic analysis and chemical derivatization. the isolated compounds were also evaluated for cytotoxicity toward human cancer c ... | 2006 | 16495058 |
| junceellolides j-l, 11,20-epoxybriaranes from the gorgonian coral junceella fragilis. | three new 11,20-epoxybriarane diterpenoids, junceellolides j-l (1-3), along with a known metabolite, 4, have been isolated from the gorgonian coral junceella fragilis. the structures of these metabolites were elucidated using spectroscopic methods. the cyclohexane rings were found to exist in boat form in briaranes 1 and 4 and in chair form in 2 and 3. the structure of 1 was further confirmed by chemical conversion and single-crystal x-ray diffraction analysis. the relationship between (13)c nmr ... | 2006 | 16499329 |
| a clinicopathologic and molecular study of follicular lymphoma in taiwan. | the clinicopathologic and molecular features of follicular lymphoma (fl) in taiwan have not been well defined. we conducted a retrospective study including history review, immunohistochemistry, and molecular study for the major breakpoint region (mbr) of t(14;18) and correlated these findings with survival. | 2006 | 16507209 |
| lack of g2019s lrrk2 mutation in a cohort of taiwanese with sporadic parkinson's disease. | mutations in the leucine-rich repeat kinase 2 (lrrk2) gene have been shown to cause autosomal dominant and sporadic parkinson's disease (pd). we report here the frequency of a common heterozygous mutation, 2877510g>a, which produces a glycine-to-serine amino acid substitution at codon 2019 in idiopathic taiwanese pd. the extreme rarity of the g2019s mutation in our population suggests the occurrence of this mutation resulted from a common european founder. | 2006 | 16511860 |
| parvovirus b19 infection in patients with rheumatoid arthritis in taiwan. | to investigate the role of human parvovirus b19 infection in the pathogenesis of rheumatoid arthritis (ra) in taiwan. | 2006 | 16511938 |
| toxicokinetics/toxicodynamics of arsenic for farmed juvenile milkfish chanos chanos and human consumption risk in bfd-endemic area of taiwan. | this paper presents a toxicokinetic/toxicodynamic analysis to appraise arsenic (as) bioaccumulation in farmed juvenile milkfish chanos chanos at blackfoot disease (bfd)-endemic area in taiwan, whereas probabilistic incremental lifetime cancer risk (ilcr) and hazard quotient (hq) models are also employed to assess the range of exposures for the fishers and non-fishers who eat the contaminated fish. we conducted a 7-day exposure experiment to obtain toxicokinetic parameters, whereas a simple criti ... | 2006 | 16513169 |
| retrospective study of the total insertion period of peripherally inserted central catheter: discussion of anti-thrombogenic surface and other biomaterial requirements. | a retrospective study of patients' records on reviewing the purpose of venous catheter insertion (chemotherapy, blood transfusion, antibiotics or parenteral nutrition); total period of insertion; reason for catheter removal. 120 admitted patients who received fluoroscopic guide picc (4-french single lumen silicone rubber catheter) insertions into distal svc via antecubital region of forearm. we retrospectively review human factors including the patients' laboratory data of pre- and post-insertio ... | 2006 | 16518017 |
| prognostic role of c-jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in taiwan. | overexpression or activation of c-jun has been implicated in the pathogenesis of several types of cancer. treatment of oral cells with areca nut extract in culture can increase c-jun proto-oncogene mrna levels. the purpose of this study was to investigate the possible role of c-jun activation in the pathogenesis and prognosis of areca quid chewing-related oral cancer in taiwan. | 2006 | 16520839 |
| transgenerational effects of betel-quid chewing on the development of the metabolic syndrome in the keelung community-based integrated screening program. | the transgenerational metabolic effects of betel-quid chewing have been reported in mice but not in humans. | 2006 | 16522918 |
| clinical characteristics and survival of trisomy 18 in a medical center in taipei, 1988-2004. | trisomy 18 is the second most common autosomal trisomy in newborns. the birth prevalence of this disorder is approximately 1 in 3,000 to 1 in 8,000, and the life span of the majority of patients is less than 1 year. as information regarding outcome in trisomy 18 is rather fragmentary in the literature, this study is aimed at investigating the survival and natural history of trisomy 18. we also evaluated the survival age and management of trisomy 18 in two different periods, before and after the ... | 2006 | 16528742 |
| human pcdd/pcdf levels near a pentachlorophenol contamination site in tainan, taiwan. | a pentachlorophenol (pcp) manufacturing plant in southern taiwan discontinued production in 1989. the site of the abandoned plant was heavily contaminated by pcdd/pcdfs, impurities formed in the pcp production process. serum samples collected from 27 residents living near the deserted plant were evaluated to determine whether this contamination had associated serum levels of pcdd/pcdfs in local residents. the average level of 17 tested congeners ranged from 556 to 5240 pg/g lipid (mean, 1670 pg/ ... | 2006 | 16529794 |
| han chinese cell and genome bank in taiwan: purpose, design and ethical considerations. | | 2006 | 16534213 |
| association of rheumatoid factor production with fcgammariiia polymorphism in taiwanese rheumatoid arthritis. | fcgamma receptors (fcgammar) impact upon the development of inflammatory arthritis through immune complex stimulation and proinflammatory cytokine production. fcgammariia, fcgammariotaiotaiotaa and fcrgammaiiib polymorphisms were genotyped in 212 rheumatoid arthritis (ra) patients and 371 healthy control subjects using an allelic-specific polymerase chain reaction (pcr). no significant skewing in the distribution of fcgammariia h/r131, fcgammariiia f/v158 and fcgammariiib na1/na2 was found betwe ... | 2006 | 16542359 |
| prevalence of human immunodeficiency virus and sexually transmitted infections and risky sexual behaviors among men visiting gay bathhouses in taiwan. | this study aimed to investigate the prevalence of human immunodeficiency virus (hiv) and sexually transmitted infections (stis) and predictors of risky sexual behaviors among men visiting gay bathhouses. | 2006 | 16543861 |
| a comparison of major histocompatibility complex snps in han chinese residing in taiwan and caucasians. | genetic dissection of complex diseases is both important and challenging. the human major histocompatibility complex is involved in many human diseases and genetic mechanisms. this highly polymorphic chromosome region has been extensively studied in caucasians but not as well in asians. thus, we compared genotypic distributions, linkage disequilibria and haplotype blocks between caucasian and taiwan's han chinese populations. moreover, we investigated the population admixture and phylogenetic sy ... | 2006 | 16544196 |
| mutation analysis of gaucher disease patients in taiwan: high prevalence of the recncii and l444p mutations. | gaucher disease, the most prevalent lysosomal storage disease characterized by a remarkable degree of clinical variability, results from deleterious mutations in the beta-glucosidase gene. although >200 mutations in the gene for human beta-glucosidase have been described, most genotype/phenotype studies have focused on screening for a few common mutations. in the present study, whole gene sequencing analysis was performed. we sequenced eight patients with type 1, five patients with type 2, and s ... | 2006 | 16546416 |
| process of self-identity transformation in women with autistic adolescent. | the purpose of this study was to understand the self-identity transformation in women with adolescent autistic children. in this study, in-depth interviews were used to collect data. eight mothers were recruited who had autistic children aged 13-21 and who were those children's primary caregivers. each mother was interviewed from one to four times. four themes emerged through these mothers rethinking their connection with others during middle age. these included (1) relationships revisited; (2) ... | 2006 | 16547906 |
| increased prevalence of interleukin-1 receptor antagonist gene polymorphism in patients with chronic rhinosinusitis. | to assess the association of the interleukin (il)-1beta and the il-1 receptor antagonist (il-1ra) gene polymorphisms with chronic rhinosinusitis (crs). | 2006 | 16549749 |
| quantitative profile of estrogen receptor variants/isoforms in taiwanese women with breast cancer. | to quantify er variants/isoforms for women with breast cancer in taiwan, an area with remarkably low breast cancer rates, but with an early onset and poor prognosis. | 2006 | 16551498 |
| dimensions of hospital nurses' quality of working life. | this paper is a report of a study describing the quality of working life of nurses in taiwan. the purpose of the study was to gather data on which to base a questionnaire to be used in further research. | 2006 | 16553697 |
| nurses' perceptions of severe acute respiratory syndrome: relationship between commitment and intention to leave nursing. | this paper reports a study which aimed to: (1) investigate the relationship between nurses' commitment to the nursing profession and organization and their intention to leave; (2) investigate nurses' perceptions of the possibility of acquiring severe acute respiratory syndrome infection and its moderation of their commitment to the nursing profession and the organization and their consequent intentions to leave the profession and the organization following the severe acute respiratory syndrome o ... | 2006 | 16553703 |
| absence of association of a polymorphic ggc repeat at the 5' untranslated region of the reelin gene with schizophrenia. | reelin is an extracellular matrix glycoprotein that plays an important role in guiding neuronal migration, lamination and connection during embryonic brain development. several reports suggest that reduced reelin expression is associated with human mental illnesses such as schizophrenia, mood disorders and autism. human reelin cdna has been cloned and contains a polymorphic ggc repeat at the 5' untranslated region. in view of the possible regulation of reelin gene expression by this ggc polymorp ... | 2006 | 16556465 |
| spatial analysis of potential carcinogenic risks associated with ingesting arsenic in aquacultural tilapia (oreochromis mossambicus) in blackfoot disease hyperendemic areas. | this work analyzed spatially potential carcinogenic risks associated with ingesting arsenic (as) contents in aquacultural tilapia (oreochromis mossambicus) in coastal regions of southwestern taiwan, where the blackfoot disease prevails. sequential indicator simulation (sis) was used to reproduce as exposure distributions in groundwater based on their three-dimensional variability. a target cancer risk (tr) associated with ingesting as in aquacultural tilapia was calculated to evaluate the potent ... | 2006 | 16568791 |
| g-2548a polymorphism of the leptin gene is correlated with extreme obesity in taiwanese aborigines. | we examined the genetic associations of the g-2548a polymorphism in the promoter of the leptin (lep) gene and the gln223arg (q223r) polymorphism of the leptin receptor (lepr) gene with obesity. two hundred twenty-six obese aboriginal subjects (bmi > or = 27 kg/m2) and 182 aboriginal subjects with normal weight (bmi < 25 kg/m2) participated in this study. the polymorphisms of lep g-2548a and lepr q223r were genotyped by polymerase chain reaction/restriction fragment length polymorphism, and their ... | 2006 | 16571841 |
| cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: two novel mutations in the notch3 gene in chinese. | cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil) is a hereditary disorder caused by notch3 mutations, usually localized to exons 3 and 4, and characterized by recurrent subcortical infarctions, dementia and leukoencephalopathy. so far, there has been only limited information about cadasil in chinese population. | 2006 | 16580020 |
| association study of genetic polymorphisms of slc2a10 gene and type 2 diabetes in the taiwanese population. | the gene encoding solute carrier family 2, facilitated glucose transporter, member 10 (slc2a10, previously known as glucose transporter 10 [glut10]) is a promising candidate gene for type 2 diabetes since it is highly expressed in liver and pancreas and is located on human chromosome region 20q12-q13.1, a region previously shown to harbour type 2 diabetes susceptibility genes. we investigated whether the slc2a10 gene could be a type 2 diabetes susceptibility gene in the taiwanese population. | 2006 | 16586067 |
| factors influencing organotin distribution in different marine environmental compartments, and their potential health risk. | tributyltin (tbt) and triphenyltin (tpt) in different marine environmental compartments such as seawater, sediments, and inshore fishes were investigated in 21 taiwanese harbors between 2001 and 2004 in order to determine the major factors influencing their distribution. the existence of major input sources and the limited water exchange rate inside the harbors were indicated by higher tbt concentrations in seawater from inner harbor than from outer harbor areas. the levels of tbt in sediments w ... | 2006 | 16597459 |
| abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the taiwanese population- not correlated with insulin receptor substrate-1 gly972arg/ala513pro polymorphism. | insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (pcos) are related with the polymorphisms in the genes encoding the insulin receptor substrate (irs) proteins, especially gly972arg/ala513pro polymorphism being reported to be associated with type-2 diabetes and pcos. we intended to assess the prevalence of abnormal glucose tolerance (agt) and insulin resistance in taiwanese pcos women. we also tried to assess whether the particular identity of gly972arg/ala513pro polymorp ... | 2006 | 16603055 |
| the synergistic effects of the il-9 gene and environmental exposures on asthmatic taiwanese families as determined by the transmission/disequilibrium test. | asthma occurs in genetically susceptible individuals in the presence of environmental factors. the interleukin-9 (il-9) gene, one of the cytokine genes located on chromosome 5q31, plays an important role in the development of asthmatic syndrome by enhancing both t-cell and mast-cell function. this study investigated gt repeat polymorphism of the il-9 gene and the gene-environment interactions, which may predispose individuals to asthma and atopy pathogenesis. in this study, we used the transmiss ... | 2006 | 16611254 |
| characterisation of antimicrobial resistance patterns and class 1 integrons among escherichia coli and salmonella enterica serovar choleraesuis strains isolated from humans and swine in taiwan. | escherichia coli isolates from humans (n=110) and swine (n=61) and salmonella enterica serovar choleraesuis isolates (n=95) from swine in southern taiwan were characterised for antimicrobial resistance patterns and class 1 integrons. all e. coli isolates and s. choleraesuis isolates were multidrug resistant and demonstrated high resistance to beta-lactams, aminoglycosides, tetracycline, sulfonamides, spectinomycin, chloramphenicol and nalidixic acid. by polymerase chain reaction and dna sequenci ... | 2006 | 16621462 |
| human becoming practice around the globe: exploring the art of living true presence. | in this column, the human becoming practice methodology is illuminated and some of the questions that people have asked about living the art of human becoming are presented. the human becoming teaching-learning processes are discussed as a way of coming to know what it takes to live true presence, and the role of stories in teaching-learning human becoming practice is explored. previously published human becoming practice stories are presented as an answer to many of the questions that persons h ... | 2006 | 16624980 |
| amplified fragment length polymorphism, serotyping, and quinolone resistance of campylobacter jejuni and campylobacter coli strains from chicken-related samples and humans in taiwan. | the high-resolution genotyping method of amplified fragment length polymorphism (aflp) analysis was used to study the genetic relationships between campylobacter jejuni isolates from chicken-related samples (n = 32) and humans (n = 27) as well as between campylobacter coli isolates from chicken-related samples (n = 27) and humans (n = 5). these isolates were collected between 1994 and 2003 in taiwan. all c. jejuni and c. coli isolates showed highly heterogeneous fingerprints. c. jejuni isolates ... | 2006 | 16629019 |
| a common missense variant in the lrrk2 gene, gly2385arg, associated with parkinson's disease risk in taiwan. | mutations in the lrrk2 gene are a cause of autosomal dominant parkinson's disease (pd). whether lrrk2 variants influence susceptibility to the commoner, sporadic forms of pd remains largely unknown. data are particularly limited concerning the asian population. in search for novel, biologically relevant variants, we sequenced the lrrk2 coding region in taiwanese patients with pd. four newly identified variants and another variant recently found in a taiwanese pd family were tested for associatio ... | 2006 | 16633828 |
| two novel phex mutations in taiwanese patients with x-linked hypophosphatemic rickets. | x-linked hypophosphatemic rickets (xlh) is an x-linked dominant disease characterized by renal phosphate wasting, hypophosphatemia, aberrant vitamin d metabolism, and defective bone mineralization. the disease is caused by mutations in the phex gene (phosphate-regulating gene with homologies to endopeptidases on the x-chromosome) located at xp22.1. to date, a variety of phex mutations have been identified in these patients. | 2006 | 16636593 |
| a pbtk/td modeling-based approach can assess arsenic bioaccumulation in farmed tilapia (oreochromis mossambicus) and human health risks. | a biologically based risk-assessment model of arsenic (as) exposure evaluated farmed tilapia (orechromis mossambicus) and human health during tilapia consumption in an area of southwestern taiwan where blackfoot disease (bfd) occurs. the risk assessment addressed exposures to city residents who lived in taipei, taichung, and kaohsiung, as well as subsistence fishers living in the bfd area who consumed tilapia. the models implemented included a physiologically based toxicokinetic and toxicodynami ... | 2005 | 16637146 |
| association of nramp 1 gene polymorphism with susceptibility to tuberculosis in taiwanese aboriginals. | the human homologue of mice natural-resistance-associated macrophage protein 1 (nramp 1) gene, nramp 1, has been reported to play a role in susceptibility to tuberculosis in humans. the aboriginal population in taiwan has a five-fold higher prevalence of tuberculosis than people of han ethnicity. whether genetic factors such as nramp 1 polymorphism play a role in the prevalence of tuberculosis in taiwanese aboriginals should be clarified. | 2006 | 16638645 |
| cat-scratch disease in veterinary-associated populations and in its cat reservoir in taiwan. | in taiwan, the first human case of cat-scratch disease (csd) was diagnosed by a serologic test in 1998. since then, no studies have been conducted to understand the epidemiology of the infection in taiwan. therefore, this study is the first epidemiologic survey of csd in cats and humans in this country. using veterinary-associated individuals as the study population, it was identified that 1.7% of them were seropositive for b. henselae, and residence was the only factor associated with seroposit ... | 2006 | 16641017 |
| killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis. | to investigate the role of the killer cell immunoglobulin-like receptor (kir) gene's repertoire in the pathogenesis of rheumatoid arthritis (ra) in taiwan. | 2006 | 16641046 |
| xenicane-type diterpenes with cytotoxicity from xenia florida. | chromatographic investigation of an acetone extract of the octocoral xenia florida afforded three new xenicane diterpenes, namely, florxenilide a (1), florxenilide b (2), and florxenilide c (3), in addition to seven known xenicane diterpenes and two known cadinene sesquiterpenes. structures were elucidated through spectroscopic analysis, especially 2d nmr, and chemical derivatization. the absolute configuration of 1 was determined by noesy, cd, and mosher's methods. florxenilides a (1) and b (2) ... | 2006 | 16643051 |
| inhibitors of kb-like gene polymorphisms in rheumatoid arthritis. | to investigate the role of inhibitor of kb-like (ikbl) gene polymorphisms in the pathogenesis of rheumatoid arthritis (ra) in taiwan. | 2006 | 16644022 |
| arsenic exposure and type 2 diabetes: a systematic review of the experimental and epidemiological evidence. | chronic arsenic exposure has been suggested to contribute to diabetes development. we performed a systematic review of the experimental and epidemiologic evidence on the association of arsenic and type 2 diabetes. we identified 19 in vitro studies of arsenic and glucose metabolism. five studies reported that arsenic interfered with transcription factors involved in insulin-related gene expression: upstream factor 1 in pancreatic beta-cells and peroxisome proliferative-activated receptor gamma in ... | 2006 | 16675414 |
| conflicting results regarding the semaphorin gene (sema5a) and the risk for parkinson disease. | | 2006 | 16685660 |
| human intestinal capillariasis (capillaria philippinensis) in taiwan. | capillaria philippinensis was first reported in 1963 in the philippines. major outbreaks have occurred in the philippines and thailand. this article reviews the known 30 intestinal capillariasis cases in taiwan from january 1983 to december 2003. the infected cases were diagnosed each year with the exception of 1984 and 2002, making taiwan a capillaria-prevalent area. two taiwanese aboriginal tribes, the ami and paiwan, presented a high prevalence. the males and elderly also had a high infection ... | 2006 | 16687685 |
| different human papillomavirus 16/18 infection in chinese non-small cell lung cancer patients living in wuhan, china. | inconsistency in the prevalence of infection by human papillomavirus (hpv) in lung cancer patients was found between different countries with racial and geographic variations. our previous reports have indicated that a high-risk hpv 16/18 dna was frequently detected in chinese lung cancer patients living in taichung, taiwan (cheng et al. cancer res. 2001;61:2799-803). thus, we conducted this study to verify whether there was a similar hpv 16/18 infection prevalence in lung cancer patients from w ... | 2006 | 16690730 |
| polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease. | chronic obstructive pulmonary disease (copd) is a multifactorial disease influenced by genetic and environmental factors, particularly cigarette smoking. although cigarette smoke may be directly mutagenic, polymorphisms in the genes controlling acquired somatic mutations may also contribute, at least to some extent, to the observed differing susceptibilities to copd. to investigate the involvement of genetic polymorphisms of p53 and p21 in the pathogenesis of copd, the authors performed a case-c ... | 2006 | 16697770 |
| human metapneumovirus as a causative agent of lower respiratory tract infection in four patients: the first report of human metapneumovirus infection confirmed by rna sequences in taiwan. | human metapneumovirus (hmpv) has been described as a human pathogen associated with respiratory disease in most parts of the world from all age groups. this report presents the first 4 cases of hmpv disease confirmed by the sequences of pcr products in taiwan. | 2006 | 16709547 |
| first report of two taiwanese siblings with sialidosis type i: a 10-year follow-up study. | we report the clinical features, electrophysiological findings and genetic characteristics of the first two taiwanese siblings ever reported with sialidosis type i. we also provide a 10-year follow-up result. enzymological analysis revealed a primary sialidase deficit. the back-averaged electroencephalography demonstrated myoclonic jerk-related cortical activities and the somatosensory evoked potential studies revealed giant cortical components. during the 10-year follow-up, the brain magnetic r ... | 2006 | 16712870 |
| association between the tap2 gene codon 665 polymorphism and graves' disease. | a total of 95 patients with active graves' disease (gd) and 105 normal healthy subjects were enrolled in this study, which attempted to determine whether single-site polymorphisms of the transporter associated with antigen processing 2 (tap2) gene contribute to an individual's susceptibility to gd. such polymorphisms were detected using polymerase chain reaction (pcr)-based restriction analysis. associations between gd and the three site polymorphisms of the tap2 gene at codons 379, 565, and 665 ... | 2006 | 16721835 |