| effects of hiv-1 tat protein on human t cell proliferation. | in inducing immunodeficiency in human immunodeficiency virus (hiv)-1 infection, a role for the hiv-1 tat protein has been suggested. in addition to effects on viral transcription, the protein has been ascribed immunosuppressive functions, which were investigated in this study. proliferation of purified t cells to cd3 monoclonal antibodies immobilized to plastic plates was inhibited up to 70% by addition of 5 micrograms/ml of the tat protein. this inhibitory effect, however, was not observed in t ... | 1992 | 1396975 |
| nucleocapsid protein of hiv-1 and its zn2+ complex formation analysis with electrospray mass spectrometry. | the zn2+ binding properties of the synthetic nucleocapsid protein (ncp7) of hiv-1, containing two zinc-binding domains, have been studied using electrospray mass spectrometry (es-ms). es-ms measurements revealed strong binding of zn2+ by ncp7. its shorter fragments, ncp7-(1-35)- and (29-55)-peptides, each containing only one zinc-binding domain, bind one equivalent of zn2+ ions tightly. es-ms studies allows these fragments to be distinguished in terms of their binding affinity: they showed stron ... | 1992 | 1397325 |
| gas gangrene following intra-arterial injection of oral medication in a drug abuser. | we report a patient in whom intra-arterial injection of oral medication led to the development of fulminating gas gangrene and death, despite the initial clinical symptoms being minor. we believe that prophylactic antibiotics should be administered to patients following intra-arterial injection of oral medication especially if immunocompetence, such as from human immunodeficiency virus (hiv) infection, is likely. | 1992 | 1397355 |
| the hiv-1 nef gene product. | | 1992 | 1397652 |
| discovery and characterization of an hiv-1 tat antagonist. | ro 5-3335, 7-chloro-5-(2-pyrryl)-3h-1,4-benzo-diazepin-2-(h)-one, has been shown to inhibit gene expression controlled by the human immunodeficiency virus-1 (hiv-1) ltr promoter. the inhibition was specific for the viral transcriptional transactivator tat. the compound did not inhibit the basal activity of the hiv-1 ltr or the activity of promoters not responsive to tat. consistent with its mode of action, ro 5-3335 inhibited hiv-1 replication (ic50 = 0.1-1 microm) by reducing viral rna synthesi ... | 1992 | 1397654 |
| proteins with abortifacient, ribosome inactivating, immunomodulatory, antitumor and anti-aids activities from cucurbitaceae plants. | 1. the biochemical characteristics and biological activities of eight cucurbitaceae plant proteins designated trichosanthin (isolated from tubers of trichosanthes kirilowii), beta-trichosanthin (isolated from tubers of trichosanthes cucumeroides), alpha- and beta-momorcharins (isolated from seeds of momordica charantia), momorchochin (isolated from tubers of momordica cochinchinensis), luffaculin (isolated from seeds of luffa acutangula) and luffin-a and luffin-b (isolated from seeds of luffa cy ... | 1992 | 1397965 |
| a high-level expression vector for human cells. | we have developed a vector (psupexp), for high-level expression of genes, that is dependent on transactivation of the human immunodeficiency virus 1 (hiv-1) long terminal repeat (ltr) by the hiv-1 transactivator protein, tat. the foreign gene, expressed under transcriptional control of the hiv-1 ltr, and the tat gene, expressed under transcriptional control of sv40 early promoter, are expressed from the same plasmid. the vector also has the neomycin resistance-encoding gene (neo), with g418 bein ... | 1992 | 1398142 |
| post-transfusional human retrovirus infection in 41 italian beta-thalassemic patients. | previous studies have demonstrated that htlv-i is present in italy both in endemic form in southern apulia and in epidemic form among the population of intravenous drug addicts. in the present paper we intend to evaluate the risk for transfusional htlv-i transmission in our country, as well as the already known risk for hiv1. | 1992 | 1398283 |
| neuropathology of the spinal cord in the acquired immunodeficiency syndrome. | the neuropathologic findings in the spinal cord were reviewed in 138 consecutive autopsies of patients with the acquired immunodeficiency syndrome. in all cases both the brain and spinal cord were examined by conventional histologic techniques, and in 63 cases immunohistochemistry was used to detect human immunodeficiency virus (hiv), toxoplasma gondii, cytomegalovirus, and jc papovavirus antigens. the most common observation was a normal spinal cord (60%). vacuolar myelopathy (vm) was observed ... | 1992 | 1398640 |
| phlebotomy practices/needles stick injuries/hepatitis b status/among interns in a dublin hospital. | needlestick injury is the most important risk event for human immunodeficiency virus (hiv) and hepatitis b virus (hbv) transmission to health-care workers. we examined phlebotomy practices, the frequency of needle stick injuries, the reporting of such injuries and hepatitis b status among interns in st james's hospital during a six month period. this study took the form of a questionnaire. the response rate was 100%. 72% had at least one needlestick injury during this time period, 23% had injuri ... | 1992 | 1399472 |
| hiv envelope protein is recognized as an alloantigen by human dr-specific alloreactive t cells. | recent studies from this laboratory reported the mapping of the full profile of t-cell allorecognition regions of hla-dr2 beta subunit. the results indicated the presence of an allodeterminant within dr2 beta regions 141-156. in another study, we have shown that this allodeterminant is one of five regions of structural homology between the dr2 beta molecule and the hiv-envelope protein gp120 region 254-268. the fact that gp120 peptide 254-268 is homologous to the allodeterminant within the dr2 b ... | 1992 | 1399720 |
| activity and dimerization of human immunodeficiency virus protease as a function of solvent composition and enzyme concentration. | the activity of human immunodeficiency virus 1 (hiv-1) protease has been examined as a function of solvent composition, incubation time, and enzyme concentration at 37 degrees c in the ph 4.5-5.5 range. glycerol and dimethyl sulfoxide inhibit the enzyme, while polyethylene glycol and bovine serum albumin activate the enzyme. when incubated at a concentration of 50-200 nm, the activity of the protease decreases irreversibly with an apparent first-order rate constant of 4-9 x 10(-3) min-1. the pre ... | 1992 | 1400318 |
| equal inhibition of hiv replication by stereoisomers of phosphatidyl-azidothymidine. lack of stereospecificity of lysosomal phospholipase a1. | glycerol-1-p and glycerol-3-p stereoisomers of dipalmitoylphosphatidylazidothymidine were synthesized and found to have equal antiretroviral activity in hiv-infected ht4-6c cells. it was anticipated that the glycerol-1-p isomer would be less active because of slow metabolic conversion by cellular phospholipases a and c, but the antiretroviral results suggested that the human cell line (ht4-6c) may have phospholipases capable of hydrolyzing 2,3-dipalmitoyl-sn-glycerol-1-phospho-5'-azidothymidine ... | 1992 | 1400346 |
| antagonistic effect of interferon-gamma on tat-induced transactivation of hiv long terminal repeat. | interferon-gamma (ifn-gamma) has been shown to inhibit human immunodeficiency virus (hiv) replication in macrophages. however, the site of its effect on the hiv infectious cycle is unknown. we show here that ifn-gamma inhibits the transactivation of hiv long terminal repeat (ltr) during viral infection and that it antagonizes tat effect in ht4lacz-1 cells. ht4lacz-1 is an indicator cd4+ hela cell line for hiv infectivity, because it harbors a hiv ltr-lacz gene susceptible to transactivation by t ... | 1992 | 1400376 |
| human dna polymerases alpha and beta are able to incorporate anti-hiv deoxynucleotides into dna. | deoxynucleoside analogs, azt and/or ddn, are the therapeutic agents currently utilized to inhibit the human immunodeficiency virus (hiv) reverse transcriptase. the effects of their anabolic products, azt-triphosphate (azt-tp) and ddctp on human cellular dna metabolic processes were studied using highly purified, structurally and enzymatically defined forms of the two major human host dna polymerases, alpha and beta, and compared to those of the reverse transcriptase purified from hiv viron. huma ... | 1992 | 1400458 |
| indeterminate western blot patterns in a cohort of individuals at high risk for human immunodeficiency virus (hiv-1) exposure. | our objective was to map serial patterns of western blot reactivity over time of a cohort of initially elisa-negative, western blot-indeterminate individuals from a high-risk group and to determine if these individuals were at increased risk of harboring occult hiv-1 infection. a 2-year prospective study used serial elisa, two types of western blot, immunologic profiles, hiv-1 culture, and analysis by polymerase chain reaction. subjects were 20 elisa-negative, western blot indeterminate homosexu ... | 1992 | 1400898 |
| relationship between frequency of infectious human immunodeficiency virus type 1-harboring cells and kinetics of viral replication: a simple procedure for quantitation of infectious virus-carrying cells in blood samples. | statistical analysis of a limiting dilution assay (lda) showed that the occurrence of infectious human immunodeficiency virus type 1 (hiv-1)-harboring cells in serially diluted samples of peripheral blood mononuclear cells (pbmcs) of hiv-1-seropositive patients fits the model describing a single-hit poisson distribution. this observation led to the discovery that there is a direct correlation (r = 0.957) between the number of hiv-1-positive cells and the time when viral culture produces 1 ng of ... | 1992 | 1400950 |
| detection of binding antibodies to native and recombinant human immunodeficiency virus type 1 envelope glycoproteins following recombinant gp160 immunization measured by flow cytometry and enzyme immunoassays. the aids vaccine clinical trials network. | the ability of antibody induced by vaccination with recombinant gp160 (rgp160) to bind to native and recombinant human immunodeficiency virus type 1 (hiv-1) envelope glycoproteins was measured. thirty-three hiv-1-seronegative healthy adult volunteers were injected four times with 40 or 80 micrograms of an hiv-1lav envelope glycoprotein candidate vaccine per dose. the vaccine consisted of rgp160 produced in insect tissue culture cells infected with a recombinant baculovirus which contains the gp1 ... | 1992 | 1400960 |
| development of oligonucleotide primers and probes against structural and regulatory genes of human immunodeficiency virus type 1 (hiv-1) and their use for amplification of hiv-1 provirus by using polymerase chain reaction. | the polymerase chain reaction is a powerful technique for amplifying a few copies of double-stranded genetic material to millions of copies in a few hours. the sensitivity and specificity of the polymerase chain reaction technique depend to some extent on the nucleotide sequences of the oligonucleotide primer pair used in the amplification. we report new oligonucleotide primers and probes which can be used for the amplification and detection of human immunodeficiency virus type 1 provirus sequen ... | 1992 | 1400991 |
| neisseria spp. and aids. | neisseria meningitidis from various serogroups and two commensal neisseriae (n. sicca and n. perflava) were isolated from 15 patients at various stages of human immunodeficiency virus infection in this clinical and bacteriological study. the cases were grouped into the following three classes: (i) infections with an n. meningitidis strain of a serogroup known to be pathogenic (a, b, or c) and apparently independent of the human immunodeficiency virus infection, (ii) infections with a n. meningit ... | 1992 | 1400993 |
| early detection of antibody to human immunodeficiency virus type 1 by using an antigen conjugate immunoassay correlates with the presence of immunoglobulin m antibody. | sequential plasma samples obtained from 16 individuals who seroconverted were tested for the presence of antibody to human immunodeficiency virus type 1 (hiv-1) by an antigen conjugate enzyme immunoassay (eia) and a conventional antibody conjugate assay. in 11 of these individuals, the antigen conjugate assay detected antibody to hiv-1 2 to 11 days (mean, 5.5 days) earlier than the antibody conjugate assay. in 11 individuals, hiv-1 p24 antigen was detected a median of 6.5 days (range, 3 to 14 da ... | 1992 | 1401002 |
| evidence that lo's mycoplasma (mycoplasma fermentans incognitus) is not a unique strain among mycoplasma fermentans strains. | mycoplasma fermentans incognitus has attracted much interest either as a cofactor for the progression of aids or as a pathogenic agent in non-aids-related diseases (s.-c. lo, m. s. dawson, p. b. newton iii, m. a. sonoda, j. w.-k. shih, w. f. engler, r. y.-h. wang, and d. j. wear, am. j. trop. med. hyg. 41:364-376, 1989; s.-c. lo, m. s. dawson, m. wong, p. b. newton iii, m. a. sonoda, w. f. engler, r.y.-h wang, j. w.-k. shih, h. j. alter, and d. j. wear, am. j. trop. med. hyg. 41:601-616, 1989; s ... | 1992 | 1401012 |
| evaluation of an indirect immunofluorescence assay for confirmation of human immunodeficiency virus type 1 antibody in u.s. blood donor sera. | an indirect immunofluorescence assay (ifa) was evaluated as a confirmatory test for antibody to human immunodeficiency virus type 1 in u.s. blood donor sera previously found to be repeatedly reactive by enzyme immunoassay. ifa results were 100% concordant with a licensed western blot (immunoblot) for 53 negative and 49 positive samples. four samples which exhibited antibody to viral proteins from more than one gene, yet were indeterminate by western blot by the manufacturer's criteria, were also ... | 1992 | 1401028 |
| activation of infectious virus from latent human immunodeficiency virus infection of monocytes in vivo. | individuals infected with hiv may be asymptomatic for years before progressing to overt aids. since hiv can latently infect monocytoid cell lines, we examined whether hiv latency occurs in monocytes in vivo. freshly isolated monocytes from asymptomatic seropositive individuals examined before and after culture were positive for hiv dna, but not rna, as measured by polymerase chain reaction, showing that hiv latency occurs in monocytes in vivo. coculture of these latently infected monocytes with ... | 1992 | 1401081 |
| neuroretinitis due to seronegative syphilis associated with human immunodeficiency virus. | syphilis serologic testing is felt to be extremely reliable. a case of syphilitic neuroretinitis is reported where serologic testing was negative due to human immunodeficiency virus infection. a prompt response to high-dose intravenous penicillin was achieved. | 1992 | 1401162 |
| adenovirus infection of the large bowel in hiv positive patients. | to describe the microscopic appearance of adenovirus infection in the large bowel of human immunodeficiency virus (hiv) positive patients with diarrhoea. | 1992 | 1401177 |
| alopecia universalis in a patient seropositive for the human immunodeficiency virus. | | 1992 | 1401321 |
| perceptions of aids susceptibility among minority and nonminority women at risk for hiv infection. | two hundred seventy-two women sampled from mass transit waiting areas in an urban center completed anonymous surveys of aids-related risk behavior, perceptions of susceptibility, and knowledge. variable patterns of human immunodeficiency virus (hiv) risk behaviors were identified, with 22% of women reporting high-risk behavior. perceptions of susceptibility were associated with an interaction between ethnicity and level of risk; nonminority women at high risk reported greater concern about aids ... | 1992 | 1401388 |
| independent and synergistic effects of disulfide bond formation, beta 2-microglobulin, and peptides on class i mhc folding and assembly in an in vitro translation system. | we have examined the post-translational processing, intrachain disulfide bond formation, folding, and assembly of mhc class i h chains with beta 2-microglobulin after coupled in vitro translation of homogeneous mrna and transport of nascent chains into canine microsomal vesicles. the formation of native alpha 3 domain conformation was dependent on conditions that optimized intrachain disulfide bond formation, and efficient folding of the alpha 1 alpha 2 domain required exposure to antigenic pept ... | 1992 | 1401922 |
| factors influencing hiv-1 banding patterns in miniaturized western blot testing of dried blood spot specimens. | in the hiv seroprevalence survey among childbearing women (scbw), antibodies to human immunodeficiency virus type 1 are detected using enzyme immunoassays (eia) and western blot (wb) methods modified to accommodate samples of blood dried on special collection paper. dried blood spot (dbs) eluates positive by eia are tested by one of two wb methods, the miniblot technique using equipment from immunetics corporation and the pbs integra assay (pageblot) from genetic systems. in this report we compa ... | 1992 | 1401956 |
| incidence of zidovudine-resistant human immunodeficiency virus isolated from patients before, during, and after therapy. | the zidovudine sensitivity of 372 isolates of human immunodeficiency virus (hiv) obtained from 237 patients before, during, and after treatment with zidovudine was examined. virus resistant to > 0.5 micrograms/ml (1.87 microm) zidovudine was isolated from most patients (93%) after 36 months of therapy. zidovudine-sensitive virus was isolated from 5 of 15 patients who had ended antiretroviral therapy but had previously shed resistant virus. the emergence of sensitive virus after end of therapy ap ... | 1992 | 1402026 |
| diagnosis of vertical human immunodeficiency virus type 1 infection by whole blood culture. | the qualitative and quantitative performance of a human immunodeficiency virus type 1 (hiv-1) whole blood culture method was assessed for use in the diagnosis of vertical hiv-1 infection. this method requires < 1 ml of whole blood and allows for the quantification of blood virus load. hiv-1 was isolated from 36 (95%) of 38 whole blood specimens from 27 hiv-1-infected children compared with 0 of 16 whole blood specimens from 16 uninfected children. hiv-1 titers were significantly higher in severe ... | 1992 | 1402027 |
| initial low cd4 lymphocyte counts in recent human immunodeficiency virus infection and lack of association with identified coinfections. | initial cd4 lymphocyte counts were studied in 244 patients with human immunodeficiency virus (hiv) seroconversion. the cd4 cell counts at initial presentation after seroconversion were normally distributed (mean, 579/mm3; sd, 252). the mean percentage of cd4 cells was 26.1% (sd, 5.6). cd4 cell counts were < 500/mm3 in 41% and < 200/mm3 in 4%. the mean calculated duration of hiv infection was 7.7 months, which was not significantly different between the highest and lowest cd4 count quartiles (8.1 ... | 1992 | 1402028 |
| effect of human immunodeficiency virus infection on cell-mediated immunity in tuberculosis. | | 1992 | 1402040 |
| neoplastic disease in the head and neck of patients with aids. | immunosuppression increases the risk of developing malignancies. in immunosuppression due to human immunodeficiency virus (hiv) disease the common head and neck tumors are kaposi's sarcoma and non-hodgkin's lymphoma. squamous cell carcinoma has also been reported. kaposi's sarcoma is the commonest neoplastic disease in aids. the incidence of lymphoma is rapidly increasing. this article reviews the incidence, clinical presentation and management of these diseases in the head and neck in aids pati ... | 1992 | 1402051 |
| [an effective concentration method for human immunodeficiency virus type 1 (hiv-1)]. | we designed an effective virus concentration method to prevent the infection with human immunodeficiency virus type 1 (hiv-1) in laboratories. the absorbent of minicon concentrators (amicon division, m.r. grace & co.-conn.) was changed to chitin, a mucopolysaccharide extracted from the shells of japanese pink crab. hiv-1 in the supernatant of hiv-1 infected molt-4 cells was concentrated by minicon and the new concentrators. the new concentrator showed good concentration rate and equality of conc ... | 1992 | 1402090 |
| ultra-high-resolution scanning electron microscopy of vaccinia virus and its recombinant carrying the gag gene of human immunodeficiency virus type 1. | fl cells infected with vaccinia virus or its recombinant carrying the gag gene of human immunodeficiency virus type 1 (hiv-1) were examined by ultra-high-resolution scanning electron microscopy. virions, whether located extracellularly or intracellularly, had a brick-shaped or watermelon appearance as a whole. extracellular virions observed on the surface of infected cells had variable surface ultrastructures depending on the manner in which particular virions were wrapped in cell membranes. mos ... | 1992 | 1402523 |
| crosslinking cd4 by human immunodeficiency virus gp120 primes t cells for activation-induced apoptosis. | during human immunodeficiency virus (hiv) infection there is a profound and selective decrease in the cd4+ population of t lymphocytes. the mechanism of this depletion is not understood, as only a small fraction of all cd4+ cells appear to be productively infected with hiv-1 in seropositive individuals. in the present study, crosslinking of bound gp120 on human cd4+ t cells followed by signaling through the t cell receptor for antigen was found to result in activation-dependent cell death by a f ... | 1992 | 1402655 |
| stable expression of transdominant rev protein in human t cells inhibits human immunodeficiency virus replication. | the human immunodeficiency virus (hiv) rev protein is essential for viral structural protein expression (gag, pol, and env) and, hence, for viral replication. in transient transfection assays, mutant forms of rev have been identified that inhibit wild-type rev activity and therefore suppress viral replication. to determine whether such transdominant rev proteins could provide long-term protection against hiv infection without affecting t cell function, t leukemia cell lines were stably transduce ... | 1992 | 1402661 |
| surveillance of human immunodeficiency virus (hiv) antibodies in medicolegal autopsies in finland--monitoring early changes in hiv-seropositivity among risk groups and average population. | in order to cooperate with voluntary screening programs aimed at the surveillance of the hiv epidemic in finland, we have studied medicolegal autopsies for hiv antibodies since 1986 using an enzyme immunoassay on postmortem sera. the investigation covered 47.4% and 39.2%, respectively, of all deaths under the age of 65 years in the metropolitan areas of helsinki and turku--two cities on the densely populated southern coast of finland from which most hiv infections have thus far been detected. ni ... | 1992 | 1402751 |
| reduced azole susceptibility of oral isolates of candida albicans from hiv-positive patients and a derivative exhibiting colony morphology variation. | approximately 50% (15/28) of a selection of oral isolates of candida albicans from separate individuals infected with the human immunodeficiency virus (hiv) exhibited low susceptibility to ketoconazole as determined by hyphal elongation assessment. nine of these isolates exhibited colony morphology variation or switching at 37 degrees c, of which six expressed low ketoconazole susceptibility. to determine whether colony morphology variation could give rise to derivatives with reduced azole susce ... | 1992 | 1402791 |
| dideoxyinosine for chronic hepatitis b infection. | six patients positive for both human immunodeficiency virus (hiv) and hepatitis b were studied to assess the effect of dideoxyinosine (ddi) on hepatitis b virus (hbv) replication. two patients died during the follow-up period and four had at least 8 weeks of therapy. one patient demonstrated hbv dna suppression and became transiently negative. in the remaining five patients, there was no appreciable change in hbv dna levels during ddi therapy. ddi was well tolerated in all patients, the only sig ... | 1992 | 1402828 |
| hiv-2 infections in a rural senegalese community. | in a community study in rural senegal, 22 human immunodeficiency virus type-2 (hiv-2) seropositive cases and 64 matched controls were examined clinically and evaluated immunologically. the presence of clinical signs was highly correlated with hiv-2 seropositivity: 9 anti-hiv-2 positive patients and 5 controls presented with clinical signs (odd ratio [or] = 8.2, confidence limits [cl] 2-35). the main symptom associated with hiv-2 seropositivity was a chronic cough (or = 18.5, cl 1.8-899). the pre ... | 1992 | 1402831 |
| sera from simian immunodeficiency virus-infected rhesus macaques inhibit lymphocyte proliferation. | rhesus macaque monkeys infected with the simian immunodeficiency virus (siv) develop a syndrome mimicking acquired immunodeficiency syndrome (aids) in humans. we had demonstrated previously that sera from individuals infected with human immunodeficiency virus (hiv) inhibit the proliferation of lymphocytes from healthy noninfected subjects and that this phenomenon was associated with the development of clinical aids. thus, we sought to determine whether sera from siv-infected monkeys would also i ... | 1992 | 1403349 |
| optimism, coping, psychological distress, and high-risk sexual behavior among men at risk for acquired immunodeficiency syndrome (aids). | in a cohort of gay men responding to the threat of acquired immunodeficiency syndrome (aids), dispositional optimism was associated with less distress, less avoidant coping, positive attitudes as a coping strategy, and fewer aids-related concerns. men who knew they were seropositive for human immunodeficiency virus (hiv) were significantly more optimistic about not developing aids than men who knew they were seronegative for hiv. this aids-specific optimism was related to higher perceived contro ... | 1992 | 1403625 |
| a model-based estimate of hiv infectivity via needle sharing. | critical to understanding the spread of the human immunodeficiency virus via needle sharing among drug users is the infectivity, i.e., the conditional probability of infection given injection with a shared, contaminated syringe. a simple mathematical model was constructed that relates infectivity to the prevalence of infection in needles used by drug users, the mean shared injection frequency among drug users, the probability that a needle is disinfected prior to use, and the mean aids incubatio ... | 1992 | 1403641 |
| the human immunodeficiency virus tat protein increases the transcription of human alu repeated sequences by increasing the activity of the cellular transcription factor tfiiic. | the hiv tat protein is able to upregulate the transcription by rna polymerase iii of cotransfected or endogenous cellular alu-repeated sequences in both hela and jurkat t cells. this effect is mediated by an increase in the activity of transcription factor tfiiic, which binds to the b box in the rna polymerase iii alu promoter. this is the first example of an effect of the tat protein on the transcription of a cellular gene or on the activity of a cellular transcription factor. the significance ... | 1992 | 1403646 |
| dose-dependent toxicokinetics of l-689,502, a potent human immunodeficiency virus protease inhibitor, in rats and dogs. | l-689,502, n-[2(r)-hydroxy-1(s)-indanyl]-5(s)-(1,1-dimethylethoxy- carbonylamino)-4(s)-hydroxy-6-phenyl-2(r)-(4-[2-(4- morpholinyl)ethoxy]phenyl)methyl hexanamide, is a potent inhibitor of human immunodeficiency virus-1 protease. the effect of dose on the elimination kinetics of l-689,502 was studied in rats and dogs. after i.v. administration, total plasma clearance of l-689,502 in rats decreased with increasing dose; the clearance decreased from 181 ml/min/kg at 1 mg/kg to 86 ml/min/kg at 20 m ... | 1992 | 1403775 |
| factors associated with psychological help-seeking in hiv disease. | the study was aimed at evaluating the psychosocial and psychopathological characteristics of individuals with human immunodeficiency virus (hiv) infection seeking psychological help compared with a sample not seeking help. two hundred and seventy-one hiv seropositive (hiv+ve) subjects belonging to three transmission categories (90 gay men, 154 intravenous drug users and 27 heterosexuals) who were assessed at their first clinic appointment and offered access to psychological help were studied. su ... | 1992 | 1404001 |
| patients with systemic lupus erythematosus at risk for pneumocystis carinii pneumonia. | we describe 6 cases of patients with systemic lupus erythematosus (sle) who developed pneumocystis carinii pneumonia. all were treated with high dose corticosteroids, and all developed the infection within 4 months of beginning new or revised cytotoxic therapy. all patients tested (5 of 6) were negative for human immunodeficiency virus (hiv). those patients who developed pneumocystis carinii pneumonia had more severe lymphocytopenia (median 595 vs 833/mm3) and received higher doses of corticoste ... | 1992 | 1404153 |
| six strains of human immunodeficiency virus type 1 isolated in japan and their molecular phylogeny. | five strains of human immunodeficiency virus type 1 (hiv-1) were isolated from five japanese hemophilia patients. two isolates, hiv-1[gun-1] and hiv-1[gun-2], were from brother patients with hemophilia b and the other three isolates, hiv-1[gun-3], hiv-1[gun-4], and hiv-1[gun-5], were from hemophilia a patients. another hiv-1 strain, hiv-1[gun-6], was isolated from a canadian male homosexual with aids. the restriction endonuclease cleavage maps of the proviral genomes of these six hiv-1 strains r ... | 1992 | 1404418 |
| non-acquired immune deficiency syndrome-defining malignancies in a hospital-based cohort of human immunodeficiency virus-infected patients: bordeaux, france, 1985-1991. groupe d'epidémiologie clinique du sida en aquitaine. | | 1992 | 1404453 |
| aids/hiv crisis in developing countries: the need for greater understanding and innovative health promotion approaches. | epidemiologic data on morbidity and mortality have shown that the acquired immunodeficiency syndrome/human immunodeficiency virus (aids/hiv) epidemic is relatively widespread in the developing countries of the world, especially in the already economically deprived regions of sub-saharan africa. africa is estimated to have approximately 5 million seropositive individuals, and by the year 2000, this number is expected to include 10 million hiv-infected children. improved control over this epidemic ... | 1992 | 1404473 |
| antioxidants selectively suppress activation of nf-kappa b by human t-cell leukemia virus type i tax protein. | oxygen radical scavengers, such as dithiocarbamates and cysteine derivatives, inhibit activation of the ubiquitous transcription factor nuclear factor kappa b (nf-kappa b) after treatment of cells with tumor necrosis factor, phorbol ester, and interleukin-1. an involvement of oxygen radicals was more directly evident from the induction of nf-kappa b by low concentrations of h2o2 and the demonstration that cells stimulated with various nf-kappa b inducers release h2o2 and superoxide. in this stud ... | 1992 | 1404592 |
| identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. | we have probed the structural organization of the human immunodeficiency virus type 1 integrase protein by limited proteolysis and the functional organization by site-directed mutagenesis of selected amino acid residues. a central region of the protein was relatively resistant to proteolysis. proteins with altered amino acids in this region, or in the n-terminal part of the protein that includes a putative zinc-binding motif, were purified and assayed for 3' processing, dna strand transfer, and ... | 1992 | 1404595 |
| epstein-barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of nf-kappa b activity. | the epstein-barr virus latent membrane protein (lmp) is an integral membrane protein that is expressed in cells latently infected with the virus. lmp is believed to play an important role in epstein-barr virus transformation and has been shown to induce expression of several cellular proteins. we performed a series of experiments that demonstrated that lmp is an efficient transactivator of expression from the human immunodeficiency virus type 1 long terminal repeat (hiv-1 ltr). mutation or delet ... | 1992 | 1404600 |
| macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual v3 envelope sequence homogeneity in comparison with t-cell-tropic isolates: definition of critical amino acids involved in cell tropism. | previous experiments indicate that the v3 hypervariable region of the human immunodeficiency virus (hiv) envelope protein influences cell tropism of infection; however, so far no consistent v3 sequence can account for macrophage or t-cell tropism. in these experiments, we studied infectious recombinant hiv clones constructed by using v3 region sequences of hiv isolates from 16 patients to search for sequences associated with cell tropism. remarkable homology was seen among v3 sequences from macr ... | 1992 | 1404602 |
| complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: evidence for limited defectiveness and complementation. | previous studies of the genetic and biologic characteristics of human immunodeficiency virus type 1 (hiv-1) have by necessity used tissue culture-derived virus. we recently reported the molecular cloning of four full-length hiv-1 genomes directly from uncultured human brain tissue (y. li, j. c. kappes, j. a. conway, r. w. price, g. m. shaw, and b. h. hahn, j. virol. 65:3973-3985, 1991). in this report, we describe the biologic properties of these four clones and the complete nucleotide sequences ... | 1992 | 1404605 |
| coexpression of the simian immunodeficiency virus env and rev proteins by a recombinant human adenovirus host range mutant. | recombinant human adenoviruses (ads) that replicate in the intestinal tract offer a novel, yet practical, means of immunoprophylaxis against a wide variety of viral and bacterial pathogens. for some infectious agents such as human immunodeficiency virus (hiv), the potential for residual infectious material in vaccine preparations must be eliminated. therefore, recombinant human ads that express noninfectious hiv or other microbial proteins are attractive vaccine candidates. to test such an appro ... | 1992 | 1404612 |
| an adenosine at position 27 in the human immunodeficiency virus type 1 trans-activation response element is not critical for transcriptional or translational activation by tat. | tat protein binds to the trans-activation response (tar) element of human immunodeficiency virus type 1 rnas and activates gene expression at the level of transcription in mammalian cell lines and translation in xenopus oocytes. certain residues within tar are important for tat binding in vitro, including residue a-27, which appears to be able to be modified in a tat-dependent manner in xenopus oocytes (l. sharmeen, b. bass, n. sonenberg, h. weintraub, and m. groudine, proc. natl. acad. sci. usa ... | 1992 | 1404615 |
| minimal requirements for the human immunodeficiency virus type 1 v3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution. | the third variable domain (v3) of the human immunodeficiency virus type 1 external envelope contains determinants of cell tropism, cytopathicity, and infectivity and elicits antibodies able to block infectivity in vitro and in vivo. our study encompassed point-mutational analysis of hxb-2 viruses containing patient-derived v3 regions and expressing a non-syncytium-inducing, low-replicating phenotype in t-cell line supt1. the mutation within v3 of a serine at position 306 into an also naturally o ... | 1992 | 1404617 |
| human immunodeficiency virus type 1 gag-protease fusion proteins are enzymatically active. | we have introduced mutations into the region of the genome of human immunodeficiency virus type 1 (hiv-1) that encodes the cleavage sites between the viral protease (pr) and the adjacent upstream region of the polyprotein precursor. segments containing these mutations were introduced into plasmids, and the retroviral proteins were expressed in escherichia coli. the mutations prevented cleavage between the pr and the adjacent polypeptide; however, other pr cleavage sites in the polyprotein were c ... | 1992 | 1404618 |
| restoration of cell surface cd4 expression in human immunodeficiency virus type 1-infected cells by treatment with a tat antagonist. | productive infection of t lymphocytes with human immunodeficiency virus type 1 (hiv-1) is accompanied by a diminution of surface cd4 receptors. treatment of chronically hiv-1-infected cd4-negative t cells in vitro with the tat antagonist ro 5-3335 resulted in a drug dose-dependent decrease in virus protein production and a reciprocal increase in surface cd4 display. the drug-treated cells remained viable, showed significantly reduced levels of the full-length and spliced hiv-1 mrnas as detected ... | 1992 | 1404619 |
| binding of serum immunoglobulins to collagens in iga nephropathy and hiv infection. | the mechanism of the binding of iga to the mesangium in iga nephropathy (igan) is unknown. interactions between iga and components of the mesangial matrix may contribute. we measured by enzyme-linked immunosorbent assay the binding of serum iga, igg, and igm from patients with igan, human immunodeficiency virus type i (hiv) infection, and healthy controls to purified native collagen types i to vi, and to an extract of normal kidney tissue. hiv infection is an appropriate disease control because ... | 1992 | 1405320 |
| [evaluation of the demand for tests for the detection of anti-human immunodeficiency virus antibodies in catalonia]. | most programs for the control of the acquired immunodeficiency syndrome (aids) contemplate the registry of cases as the principal source of information. despite the fact that these data have permitted important epidemiologic and clinical aspects of the disease to become known epidemiologic surveillance systems should be developed based on the detection of infection by the human immunodeficiency virus (hiv). | 1992 | 1405804 |
| [the impact of infection by the human immunodeficiency virus in the organization of health care services: new alternatives in health care]. | | 1992 | 1405805 |
| special health considerations for travelers. | special health considerations include many issues that affect travelers at both ends of the age spectrum. pulmonary diseases may seriously alter the physiologic responses to both cabin pressures in commercial airliners and exposure to high altitudes, but many of these responses can be predicted by blood gas determinations and simple measurements of pulmonary function conducted at sea level. cardiac events represent the most common and unpredictable health problems that threaten both serious morb ... | 1992 | 1405820 |
| [retrospective study of infection by the human immunodeficiency virus in pregnant women. future of the child and the mother]. | 5.4% (108 of 2,000) women have been confirmed for hiv 1 infection in brazzaville in 1987. 1,172 deliveries have been registered by study, 7.76% have been occurred in hiv+ women. the prevalence of miscarriages was significantly, higher in hiv+ women than in hiv- ones (p less than 0.001). the birth-weight of new-borns was not significantly different among the children born to hiv+ and hiv- mothers. there were the various probable reasons of death of children born to hiv+ mothers. more frequently t ... | 1992 | 1406211 |
| [endocrinological aspects of acquired immunodeficiency syndrome (aids)]. | the acquired immunodeficiency syndrome (aids) is a severe disease. lung, brain and digestive complaints that result in opportunistic infections and neoplasms are the most documented. the endocrine disorders, the description of which is recent on the basis of post-mortem data, motivated some authors to undertake studies in order to evaluate endocrine function in patients infected with human immunodeficiency virus (hiv). an increase in serum cortisol level due to stress adaptation in the early sta ... | 1992 | 1406212 |
| [simultaneous association of tubercular meningitis and cryptococcal meningitis in an african with human immunodeficiency virus hiv positive serology. university hospital center of bujumbura,burundi]. | the authors report a connection between a meningitis tuberculosis and a meningoencephalitis with cryptococcus in the case of an african vih+. the diagnostic of a meningitis tuberculosis was retained on an indirect arguments, this of meningoencephalitis of direct arguments (antigen cryptococcus, cultivation on sabouraud environment). the pulmonary tuberculosis and/or extrapulmonary tuberculosis is current in central africa during hiv infection, as well as the crytococcosis during aids. but, any o ... | 1992 | 1406216 |
| [peripheral and bone marrow hematological modifications in infection by the human immunodeficiency virus (hiv) in central africa. diagnostic and prognostic significance]. | from the 24 march 1988 to the 15 june 1989, we noticed the peripheric and medullar haematologic modifications of 46 patients infected by hiv, classified in the group iv of cdc. the haematologic modifications found are: a peripheric cytopenia with a constant anemia often serious, a leuconeutropenia, a mild or missing lymphopenia. in comparison: the bone marrow is often rich in the different lineage with more often a sharp lymphoplasmocytal reaction, sometime very characteristic on the cytological ... | 1992 | 1406219 |
| focus formation by the human immunodeficiency virus (hiv) in the immobilized mt-4 cell culture and its application to the evaluation of anti-hiv agents. | immunofluorescence studies were performed on the infection of monolayer cultures of immobilized mt-4 cells with human immunodeficiency virus type 1 (hiv-1). by using the anti-viral p24 monoclonal antibody, we could observe formation of foci of p24 antigen-positive cells within 3 to 4 days when the infection was initiated with a relatively small amount of the virus. frequency of the focus formation was in proportion to the dose of input virus (ranging from 0.001 to 0.1 pfu/cell), which allowed us ... | 1992 | 1406373 |
| mechanism of action of regulatory proteins encoded by complex retroviruses. | complex retroviruses are distinguished by their ability to control the expression of their gene products through the action of virally encoded regulatory proteins. these viral gene products modulate both the quantity and the quality of viral gene expression through regulation at both the transcriptional and posttranscriptional levels. the most intensely studied retroviral regulatory proteins, termed tat and rev, are encoded by the prototypic complex retrovirus human immunodeficiency virus type 1 ... | 1992 | 1406488 |
| hiv counseling and testing services from public and private providers--united states, 1990. | human immunodeficiency virus (hiv) counseling and testing (ct) services are key elements of the national hiv-prevention strategy (1,2). although the number and characteristics of persons receiving ct through publicly funded programs are monitored by cdc's ct data system (3), this system does not provide information about persons tested for hiv antibody by physicians in the private sector, hospitals, and other nonpublicly funded sources. this report summarizes data from cdc's 1990 national health ... | 1992 | 1406566 |
| surveillance for occupationally acquired hiv infection--united states, 1981-1992. | public health surveillance for and risk-assessment studies of human immunodeficiency virus (hiv) infection provide a basis for formulating measures to minimize the risk for occupational transmission of hiv to health-care workers (1-6). data on occupational transmission of hiv have been provided by two cdc-supported national surveillance systems: one initiated in 1981 for acquired immunodeficiency syndrome (aids) cases and one initiated in 1991 for hiv infections acquired through occupational exp ... | 1992 | 1406579 |
| community awareness and use of hiv/aids-prevention services among minority populations--connecticut, 1991. | human immunodeficiency virus (hiv)/acquired immunodeficiency syndrome (aids)-prevention efforts supported by the federal government include programs offered through community-based organizations (cbos) and state and local health departments (1). to assess the extent of community awareness and use of these hiv/aids-prevention services among hispanics and non-hispanic blacks in three cities in connecticut, the connecticut state department of health services (csdhs) included questions on hiv/aids-p ... | 1992 | 1406580 |
| specificity of anti-p25 antibodies produced against whole hiv-1 particles or soluble forms of the protein. | specificity of anti-p25 antibodies produced against either whole human immunodeficiency virus type 1 (hiv-1) particles in humans and chimpanzees, or against soluble forms of the protein in chimpanzees and rabbits was analyzed by elisa using a panel of 37 long (> or = 30 residues) or shorter (9-21 residues) overlapping peptides covering the entire p25 sequence. antibodies elicited by intact virions presented similar reactivity patterns in hiv-1-infected humans and in hiv-1-infected or immunized c ... | 1992 | 1406719 |
| cardiac structure and function in children with human immunodeficiency virus infection treated with zidovudine. | abnormalities of cardiac structure and function are common in children infected with the human immunodeficiency virus (hiv). it is unclear, however, whether these abnormalities are attributable to the disease itself, associated infections, or possible cardiotoxic effects of the most commonly used treatment, zidovudine. | 1992 | 1406818 |
| the candidate oncoprotein bcl-3 is an antagonist of p50/nf-kappa b-mediated inhibition. | the candidate oncogene bcl-3 was discovered as a translocation into the immunoglobulin alpha-locus in some cases of b-cell chronic lymphocytic leukaemias. the protein bcl-3 contains seven so-called ankyrin repeats. similar repeat motifs are found in a number of diverse regulatory proteins but the motifs of bcl-3 are most closely related to those found in i kappa b proteins in which the ankyrin repeat domain is thought to be directly involved in inhibition of nf-kappa b activity. no biological fu ... | 1992 | 1406939 |
| hiv: to vaccinate or not to vaccinate? | "improbability of effective vaccination against human immunodeficiency virus ...", declares the title of a new paper by dr albert sabin. but three immunologists see flaws in his argument. | 1992 | 1406988 |
| indications for open cervical node biopsy in hiv-positive patients. | open node biopsy was the method of choice for diagnosing human immunodeficiency virus (hiv) infection before serologic testing became available. currently, the otolaryngologist is often called on to assist in the management of hiv-positive patients with troublesome cervical adenopathy. today's questions are: what is the place of fine-needle aspiration (fna), and when is open cervical node biopsy indicated. a retrospective review was undertaken of 93 consecutive cervical node biopsies performed b ... | 1992 | 1408219 |
| lack of predictive value of maternal human immunodeficiency virus p24 antigen for transmission of infection to their children. | the association of maternal-to-infant transmission of human immunodeficiency virus type 1 (hiv-1) with maternal p24 antigenemia was assessed in 86 hiv-1-infected mothers. we retrospectively examined serum or plasma samples collected in the peripartum period (delivery +/- 11 days; sd 16.89 days; range, delivery +/- 2 months). immune complexes of p24 antigen and anti-p24 antibody were dissociated using acid hydrolysis (method a, glycine-hcl buffer; method b, hcl) in an attempt to increase the sens ... | 1992 | 1408485 |
| transient seroreversion in children born to human immunodeficiency virus 1-infected mothers. | | 1992 | 1408495 |
| biologic, foster, and adoptive parents: care givers of children exposed perinatally to human immunodeficiency virus in the united states. the pediatric spectrum of disease clinical consortium. | children born to human immunodeficiency virus (hiv)-infected mothers often do not live with a biologic parent because of drug use, illness, or death of the mother. public health officials need to know the number and proportion of children who will require care by someone other than a biologic parent (alternative care giver). the pediatric spectrum of disease project, conducted in six different geographic regions in the united states, assesses issues specific to hiv in children. among the informa ... | 1992 | 1408516 |
| delayed recognition of human immunodeficiency virus infection in preadolescent children. | thirty-two (18%) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (hiv-1) were first seen, and hiv was diagnosed, when they were 4 years of age and older. initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 idiopathic thrombocytopenic purpura, 1 neutropenia, 1 anemia); recurrent bacterial infections (10); pneumocystis carinii pneumonia (3); developmental delay (1); skin disorders (2) (1 ... | 1992 | 1408540 |
| electroporation of viral transactivator proteins into lymphocyte suspension cells. | | 1992 | 1408778 |
| issues concerning women and aids: sexuality. | in the us and globally women are contracting the human immunodeficiency virus (hiv) and developing the acquired immunodeficiency syndrome (aids) the fastest. worldwide, hiv is transmitted primarily through heterosexual intercourse. in the us, the proportion of women who have contracted aids by heterosexual transmission has increased from 11% in 1984 to 34% in 1990. women are at a greater risk than men for transmission by heterosexual intercourse as the ratio of women to men who acquire aids b ... | 1992 | 1408853 |
| asymptomatic hiv infection. a primary care disease. | asymptomatic human immunodeficiency virus infection is a disease entering the primary care arena more and more frequently. patients may be monitored in this setting until complications and clinical deterioration develop (typically after several years). as the disease progresses, referral to consultants who specialize in aids may be appropriate. however, many patients do not live near a major healthcare center and do not have the financial, physical, or emotional capability to travel to one as th ... | 1992 | 1409169 |
| rapid pulmonary cavitation due to mycobacterium tuberculosis and infection with human immunodeficiency virus (hiv 1) | | 1992 | 1409205 |
| cloning and chromosomal mapping of a human immunodeficiency virus 1 "tata" element modulatory factor. | a critical regulatory element in many promoters transcribed by rna polymerase ii is the "tata" box, which is located 25-30 nucleotides upstream of the transcription initiation site. tfiid is a biochemically defined hela cell nuclear fraction containing a transcription factor activity that binds specifically to the tata box and is critical in determining both basal and regulated promoter activity. recently, the gene for a tata-binding protein was cloned and found to bind to various tata elements ... | 1992 | 1409643 |
| small amino acid changes in the v3 hypervariable region of gp120 can affect the t-cell-line and macrophage tropism of human immunodeficiency virus type 1. | human immunodeficiency virus type 1 (hiv-1) strains display a high degree of heterogeneity in their biological properties that correlate with in vivo pathogenesis of the virus. we previously demonstrated that overlapping regions encompassing the third hypervariable domain (v3), within the envelope glycoprotein gp120 determine the tropisms of hiv-1 for t-cell lines and primary macrophages. studies with mutant viruses carrying one or more amino acid substitutions in the v3 loop have now identified ... | 1992 | 1409653 |
| mutational analysis of the integrase protein of human immunodeficiency virus type 2. | purified integrase protein (in) can nick linear viral dna at a specific site near the ends and integrate nicked viral dna into target dna. we have made a series of 43 site-directed point mutants of human immunodeficiency virus type 2 in and assayed purified mutant proteins for the following activities: site-specific cleavage of viral dna (donor cut), integration (strand transfer), and disintegration. in general, the different activities were similarly affected by the mutations. we found three mu ... | 1992 | 1409671 |
| activation of expression of genes coding for extracellular matrix proteins in tat-producing glioblastoma cells. | the tat protein of human immunodeficiency virus type 1 has been increasingly implicated in directly contributing to the disease aids by altering the expression of strategic cellular genes. in this study we demonstrate that the presence of the human immunodeficiency virus type 1 regulatory protein tat is associated with a significant induction in the expression of certain protein components of the extracellular matrix in glial-derived cells. northern blot analysis reveals that in cells expressing ... | 1992 | 1409674 |
| circular dichroism and molecular modeling yield a structure for the complex of human immunodeficiency virus type 1 trans-activation response rna and the binding region of tat, the trans-acting transcriptional activator. | transcription in the human immunodeficiency virus type 1 (hiv-1) retrovirus is regulated by binding the viral tat protein (trans-acting transcriptional activator) to the trans-activation response (tar) rna sequence. here, vacuum uv circular dichroism (vuv-cd) is used to study the structure of tar and its complex with two peptide fragments that are important for tat binding to tar. the vuv-cd spectrum of tar is typical of a-form rna and is minimally perturbed when bound to either the short or the ... | 1992 | 1409690 |
| inhibition of human immunodeficiency virus type 1 replication in human t cells by retroviral-mediated gene transfer of a dominant-negative rev trans-activator. | human immunodeficiency virus type 1 (hiv-1) is the causative agent of the acquired immunodeficiency syndrome (aids). currently, no satisfactory treatment for this viral disease is available. somatic gene therapy has been proposed as an alternative to conventional therapies. several antiviral gene therapy approaches including ribozymes, antisense inhibition, and rna-decoy strategies, as well as dominant-negative mutants of hiv-1 proteins (gag, tat, and rev) have been suggested. to prove the conce ... | 1992 | 1409715 |
| buspirone-induced psychosis in a human immunodeficiency virus-infected man. | | 1992 | 1410207 |
| 15-month followup of women methadone patients taught skills to reduce heterosexual hiv transmission. | heterosexual contact with intravenous drug users accounts for a growing proportion of cases of acquired immunodeficiency syndrome (aids) among women. in an earlier study designed to reduce sexual risk behavior, the authors randomly assigned 91 methadone maintained women to information-only or skills-building conditions. modest outcomes favored participants in the skills-building group. in this 15-month followup of 62 remaining study participants, skills-training group members were more likely th ... | 1992 | 1410230 |
| sexual practices and aids knowledge among women partners of hiv-infected hemophiliacs. | about 12 percent of the women sex partners of hemophilic men who are seropositive for the human immunodeficiency virus (hiv) have themselves become seropositive. questionnaires were completed in january 1988 by 15 women who were in long-term, monogamous relationships with hiv-positive hemophiliacs; 11 of the women were not hiv seropositive and 4 were. none of the couples was abstaining from sexual intercourse, and during the 4 weeks prior to responding, the couples had intercourse a mean of 6.2 ... | 1992 | 1410231 |
| brain abnormalities in male children and adolescents with hemophilia: detection with mr imaging. the hemophilia growth and development study group. | cranial magnetic resonance (mr) imaging was performed in 124 male patients (aged 7-19 years), from 14 institutions, in whom a diagnosis of moderate to severe hemophilia was made. blood tests in all subjects were negative for human immunodeficiency virus. findings in mr studies were abnormal in 25 (20.2%) subjects. six lesions in five subjects were classified as congenital. the most commonly identified congenital lesion was a posterior fossa collection of cerebrospinal fluid (five cases). twenty- ... | 1992 | 1410372 |
| [rheumatic manifestations associated with human immunodeficiency virus infection (hiv)]. | the number of subjects presenting articular manifestations associated with hiv-infection is constantly on increase due to the growing number of seropositive patients. the pathophysiological mechanism of this association is still unknown. a recent review of the literature has shown that spondyloarthritis are the most frequently observed articular manifestations in hiv-positive patients. septic arthritis are rare but severe. the immunodepression due to hiv-infection makes it difficult to use immun ... | 1992 | 1411209 |