Publications

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an epidemic of aseptic meningitis due to echo-virus type 30: epidemiologic features and clinical and laboratory findings. 19705465458
the seattle virus watch program. i. infection and illness experience of virus watch families during a communitywide epidemic of echovirus type 30 aseptic meningitis. 19705465459
[epidemics of echo-9 virus meningitis in avignon region]. 19705470843
an outbreak among kibbutz children of a febrile illness associated with echo virus type 4. 19705472335
[virological and epidemiological studies during a combined coxsackie b3-mumps virus meningitis epidemic]. 19705478525
[epidemiologic and virologic clarification of a meningitis outbreak in the capital city of berlin, produced by type-30 echo virus]. 19705487977
epidemiologic, clinical and virological findings of exanthematous summer grippe due to echo 9 virus in tokushima district, japan. 19705489630
virus multiplication in organ cultures of human embryo small intestine. 19705491325
echo virus type 22 infection in a premature infant. 19705495064
[epidemic due to echo virus 30. i. clinical and biological study]. 19705501754
[epidemic due to echo virus 30. ii. virological and epidemiological study]. 19705501755
[a retrospective study of 83 cases of children with aseptic meningitis]. 19705503255
[incidences of echo and coxsackie virus among healthy children]. 19705504820
[meningitis due to echo 30 virus]. 19705510698
[virological and serological studies of accumulated occurrence of aseptic meningitis due to echo-virus type 30 and coxackie virus type b3 and b5]. 19705522389
aseptic meningitis associated with echovirus type 9' on oahu, hawaii. 19705530419
[meningitis aused by echo-30 virus in children]. 19715539683
[acute virus myocarditis in infants and children]. 19715558771
isolation of echovirus type 11 from two cases of burkitt's tumour and three cases of other tumours. 19675582280
segregation of mouse virulent and avirulent echo virus type 9 strains and the correlation of mouse-virulence with the "temperature" (rct/40) marker. 19675600963
[the effect of epsilon-aminocaproic acid (a protease inhibitor) on the deproteinization of echo 7 virus determined by loss of photosensitivity]. 19675607291
[experimental infection of mice induced by echo virus types 7, 8, 11 and 13 adapted to them]. 19675611753
[the antiviral action of interferon in a tissue culture]. 19675618664
[echo 6-type virus isolated from a case of acute cerebellar ataxia]. 19675625450
echo-11 as a respiratory virus: quantitation of infection in man.through a series of controlled experiments in volunteers, quantitative aspects of infection, illness, and immunity to echo-11 virus were studied. echo-11 is a transmissable viral infection in man and equally infectious to the upper respiratory and the intestinal tracts. the rate of infection was directly related to the dose of virus exposure, but any infectious dose of virus produced illness in only about one-third of the infected subjects. the infectious dose for man varied over a billionfold r ...19685653210
effects of temperature and time of exposure upon viability of echo viruses types 1, 2, 3, 5, and 20. 19685654514
an outbreak of type 26 echovirus infection with exanthem in an infant home near tokyo. 19685654948
central nervous system disease in humans due to simultaneous epidemics of echovirus type 9 and western encephalomyelitis virus infection in alberta. 19685657183
outbreak of febrile illness associated with e.c.h.o. virus type 5 in maternity unit in singapore. 19685689193
occurrence of echovirus 33 infections in ontario. 19685690127
[echovirus type 33 in southern germany (bavaria). epidemiological studies after isolation of the virus from cerebrospinal fluid]. 19685707652
[studies on echo 9 viruses. iv. studies of the genetic properties s, d, ms and e of "hot" and "cold" mutants]. 19685708827
mutability towards l plaque character of the echo virus 19 s particles. ii. variation of mutation rate figures in different s clones obtained from the same echo virus 19 strain. 19685709349
[virological and clinical observations in echo-virus infections by type 6, 30, and 33 in dresden and surroundings]. 19685731178
[epidemic occurrence of echo virus type 6 and type 30 infections during the late summer 1967 in berlin]. 19685745199
[echo virus 8(1) as cause of a group disease in a children's unit]. 19685754323
the virus watch program: a continuing surveillance of viral infections in metropolitan new york families. vii. observations on viral excretion, seroimmunity, intrafamilial spread and illness association in coxsackie and echovirus infections. 19695762818
[virological, epidemiological and clinical observations during an echo virus type 6 epidemic]. 19695792450
structural requirements of selective inhibition of enteroviruses by 2-(alpha-hydroxybenzyl)-benzimidazole and related compounds. 19695799019
the growth of echovirus 1 in hep-2 cells treated with antibody to the host cells. 19695803272
an unusual acute abdomen in pregnancy. an echo 8 virus infection. 19695805085
[epidemic aseptic meningitis in the takatsuki district in the summer of 1967]. 19695817478
[a case of paralytic disease caused by echo 9 virus]. 19655827616
[the role of echo virus 19 in the etiology of several epidemic outbreaks of an acute respiratory nature]. 19655828875
the outbreak of unknown infectious disease in the meon valley 1948, clinically diagnosed in retrospect as an echo virus infection. 19655829617
nonfatal bulbospinal paralysis due to echo 4 virus. 19655832554
[hemagglutinating properties of enteroviruses and use of the hemagglutination reaction and the hemagglutination inhibition test for practical purposes. 3. experience with the study of the hemagglutinating action of freshly isolated viruses from the echo group and possibilities for the practical use of hemagglutination tests]. 19645837359
[epidemics caused by echo-virus type 9]. 19655850132
[research on the hemagglutinating character of some strains of echo virus]. 19655864432
[sensitivity of viruses to visible light after their cultivation in the presence of vital dyes]. 19655872539
the incidence of echo virus infections in infancy and childhood. 19655874173
[an outbreak of aseptic meningitis due to eho-virus type 4 in shizuoka area]. 19655880230
[a paralytic patient with a condition similar to the spinal form of poliomyelitis and with echo 4-type virus in the spinal fluid]. 19655894488
[epidemic of aseptic meningitis due to echo virus type 4. epidemic breakout in the town of karumai-cho, iwate prefecture in 1964]. 19655894985
[an epidemic of aseptic meningitis due to echo virus 6]. 19655894998
[case of bilateral ascending paralysis caused by echo-14 virus]. 19655895234
[clinical observations on encephalomyelitis with abdominal signs at onset and on the isolation of a virus from patients' feces]. 19655897037
[summer epidemic of an exanthematous disease induced by echo 9 virus in infants]. 19665909653
acute glomerulonephritis associated with echo virus type 9 infection. 19665921336
effect of l-cystine and sulfated polysaccharides on replication of echovirus type 32 in monkey kidney cells. 19665924440
[studies on echo-9 virus. i. serological variation of echo-9 (hill) virus under the influence of temperature]. 19665933500
echovirus type 18 infection: an unusual exanthem. 19665939742
[susceptibility of some strains of human tumor cells to some viruses of the echo group]. 19665942913
[meningitis caused by echo virus type 4. an infectious disease in which relative bradycardia can occur]. 19665943399
[aseptic meningitis caused by echo virus 6 (endemia in the south of iwate prefecture in the summer of 1965)]. 19665951454
[from acute anterior poliomyelitis to poliomyelitis-like infectious syndromes]. 19665955193
experimental infection of beagles with echo virus type 6. 19665970318
[epidemic of "acute enteric disease" associated with infection by "echo 14" virus]. 19665990993
comparison of bouyant density of two mutants of echo 6 by density gradient ultracentrifugation. 19676023428
paroxysmal atrial tachycardia associated with echo 9 virus infection. 19676024218
potassium-deficient medium as a reversible nontoxic inhibitor of echo 12 virus replication. 19676028946
outbreak of aseptic meningitis due to echo-9 virus. 19676047550
chromatographic characterization of echovirus prototype strains. 19676051515
[study of heat and pressure inactivation of some echo virus strains]. 19676059743
[hemagglutination by certain types of echo virus. ii. preliminary study of the heterogeneity of hemagglutinin types 3, 6, 7, 11, 12 and 29, by chromatography on calcium phosphate]. 19676062790
[effects of hydrostatic pressure and temperature on inactivation of infectivity and hemagglutinin of several echo virus strains]. 19676062791
an outbreak of meningitis due to echovirus type 4 in grimsby in 1963. i. clinical features and virus isolation. 19676072052
outbreak of e.c.h.o. virus type 30 in a general practice. 19676081003
isolated myocarditis with recovery of echo type 9 virus from the myocardium. 19676081133
incidence of coxsackievirus b type 4 (cb4) infections concomitant with onset of insulin-dependent diabetes mellitus.from september 1979 to august 1981, a total of 25 children with newly diagnosed insulin-dependent diabetes mellitus (iddm) were admitted for management to the pediatric ward, lubbock general hospital, lubbock, texas. parents of the 24 admitted patients gave informed consent for their child to participate in the study. while hospitalized, all study patients donated early-phase (acute) blood samples and specimens for virus isolation attempts. eighteen of the 24 patients originally enrolled in the ...19846086833
[electron microscopic diagnosis of viral diseases].rotaviruses were detected in 58 among 194 children with nonbacterial gastroenteritis whose feces were examined by direct electron microscopy and immune electron microscopy (iem). identification of coxsackie b viruses isolated from patients with infectious-allergic myocarditis by iem and the neutralization tests gave similar results (coxsackie b6). besides, iem detected the accompanying virus types.19846087565
[detection of coxsackie virus b in sewage and a correlation with serous meningitis morbidity].the results of parallel virological examinations of sewage from collectors of individual districts, aeration stations, and materials from patients with serous meningitis for 1979-1982 are presented. an attempt was made to determine the relationship between the frequency of detection of enteroviruses, in particular, coxsackie b1, in sewage and the number of patients with serous meningitis. enteroviruses isolated from sewage and from patients with serous meningitis were found to be similar by the ...19846087566
aggravation of coxsackievirus, group b, type 3-induced myocarditis and increase in cellular immunity to myocyte antigens in pregnant balb/c mice and animals treated with progesterone.male balb/c mice inoculated with a heart-adapted variant of coxsackievirus, group b, type 3 (cvb3m) develop severe myocarditis characterized by extensive focal lesions of inflammatory cells and necrosis of the myocardium. females generally develop minimal myocarditis except when infected during the first and third trimesters of pregnancy. enhanced myocarditis is usually accompanied by elevations in virus concentrations in the heart, virus-specific antibody titers, and lymphocyte mediated cytolyt ...19846088088
immunopathology of acute rheumatic fever and rheumatic heart disease. the demonstration of coxsackie group b viral antigen in the myocardium.immunopathologic studies were performed on heart tissue of patients with acute rheumatic fever with carditis and chronic rheumatic heart disease. coxsackie group b viral antigen was demonstrated in 3 heart specimens of patients clinically compatible with active rheumatic fever. in two of these the pathologic findings were compatible with acute rheumatic carditis. immunoglobulin was detected in 2 and complement in one of these heart specimens. all of the chronic rheumatic heart specimens and the ...19836088158
poliovirus and echovirus survival in tetrahymena pyriformis culture in vivo.axenic cultures of tetrahymena pyriformis, strain i mt iv, grown in a defined medium at room temperature, were used to study interactions of these protozoa with vaccination strain l sc 2ab of poliovirus type 1, vaccination strain p 712 of poliovirus type 2 and with type 30 echovirus, strain 480/78. t. pyriformis cultures in media containing 10(3.0) tcd50/1 ml of type poliovirus, 10(3.0) tcd50/1 ml of type 2 poliovirus or 10(2.5) tcd50/1 ml echovirus 30 and in virus-free medium did not differ one ...19846088623
replicase gene of coxsackievirus b3.a cdna copy covering two-thirds of the coxsackievirus b3 genome was cloned in the psti site of the pbr322 vector. a nucleotide sequence containing the gene for the viral replicase and the 3' noncoding region of the coxsackievirus b3 genome was determined. the predicted amino acid sequence of the coxsackievirus b3 replicase was shown to be remarkably similar to that of the poliovirus 1 replicase. the 3' noncoding region, in contrast, was only weakly homologous to the poliovirus 1 sequence but sho ...19846088796
coxsackievirus b3 persistence and myocarditis in nfr nu/nu and +/nu mice.nfr nude (nu/nu) and euthymic (+/nu) littermates were infected with coxsackievirus b3 (cbv-3) and assayed for virus persistence in the heart, pancreas and spleen, for development of myocarditis and for antibody production. the virus grew to higher titer and persisted longer in hearts of nu/nu mice. in both types of mice there was comparable myocarditis with a mononuclear cell inflammatory response, and there was some evidence of chronic lesions for up to 21 days in +/nu and 28 days in nu/nu mice ...19846088960
influence of diabetes mellitus heredity on susceptibility to coxsackievirus b4.using the criteria of virus susceptibility as defined by the 50 percent lethal dose response and the percent cumulative mortality response it was shown that the diabetic mutation db, located on chromosome 4, exerted a particular influence on the host response to cb4 challenge. neither the yellow obese mutation ay on chromosome 2 nor the misty coat color mutation located one centimorgan from the db mutation had the same effect on cb4 response. the obese diabetic mutation ob located on chromosome ...19846089704
[viral lesions of the heart]. 19846089715
epidemiologic, clinical, and laboratory features of coxsackie b1-b5 infections in the united states, 1970-79.in the period 1970 through 1979, the coxsackie b1, b2, b3, b4, and b5 viruses constituted 24 percent of more than 18,000 enteroviruses isolated and reported through national surveillance. young children, especially males, were most frequently affected: 48 percent of the national surveillance population were less than 5 years of age, including 30 percent who were less than 1 year old. among the most frequently reported clinical syndromes associated with b infection were meningitis (in 56 percent ...19846091168
diabetes heredity and disease: effects on humoral immunity and virus infection. 19846091612
cardiac injury in myocarditis induced by coxsackievirus group b, type 3 in balb/c mice is mediated by lyt 2 + cytolytic lymphocytes.male balb/c mice inoculated with a heart-adapted variant of coxsackievirus, group b, type 3 (cvb3) develop severe myocarditis 7 days later. the lesions are characterized by mononuclear cell inflammation and myocyte necrosis. infected t-lymphocyte-deficient mice show either minimal or no cardiac injury, although virus concentrations in the hearts of t-cell-deficient and -sufficient animals are similar. adoptive transfer of 2 x 10(6) cvb3 immune thy 1+ cells into cvb3-infected t-cell-deficient mic ...19846091924
elimination of some enteroviruses in the excrements of experimentally infected rats (rattus norvegicus) and gulls (larus ridibundus).young rats of both sexes, weight 150-170 g, the first laboratory progeny of captured wild parent pairs, were used throughout this experiment. rats in two experimental groups comprising a total of 34 animals were infected orally with type 2 poliovirus vaccine strain given in each group at doses of 500, 5000 or 50,000 tcd50. in the first experiment, the presence of poliovirus in rat excrements was detectable irregularly till day 13, in the second experiment till day 2 after infection. small quanti ...19846092458
characterization and myocarditic capabilities of coxsackievirus b3 variants in selected mouse strains.two variants of coxsackievirus b3 (cvb3) were compared with the original myocarditic parent variant (cvb3m) for myocarditic properties in several strains of mice. the ts1r variant produced little to no myocarditis in any of the nine mouse strains examined. the ts10r variant and cvb3m could be differentiated on the basis of the extent of myocarditis induced in mice of selected h-2b and h-2k haplotypes and in the female versus the male responses of two other inbred strains. virus quantities recove ...19846092681
experimental coxsackie b3 virus myocarditis in golden hamsters. ii. evaluation of left ventricular function in intact in situ heart 14 months after inoculation.the hemodynamic changes of the left ventricle (lv) of golden hamsters surviving for 14 months after acute coxsackie b3 virus myocarditis were assessed with the use of a high fidelity micromanometer pressure system. of 25 infected hamsters, 10 survived to the 14th month, and 4 of these had cardiomegaly. body weight (bw) was 150.0 +/- 20.7 g (mean +/- sd) (controls, 164.5 +/- 20.1 g, ns); heart weight (hw), 0.499 +/- 0.084 g (controls, 0.448 +/- 0.035 g, ns); and hw/bw, 3.39 +/- 0.79 x 10(-3) (con ...19846092735
[lesions of the vascular tract of the eye (uveitis) caused by enteroviruses in man and monkeys].strains of poliomyelitis, echo-11 and coxsackie a7 viruses have first been shown to produce uveitis and keratouveitis in javan macaca and green monkeys inoculated intraocularly. the most marked clinical picture of the eye affection in monkeys (keratoleukoma and opacity of the anterior chamber humor, edema and hyperemia of the iris, significant changes in the iris colour, development of posterior synechias, marked dilation of the pupil to 5-7 mm, no pupil reaction to light) was observed after ino ...19846093386
[characteristics of enterovirus infection in cultures of human and mouse hybrid cells].lines of human-mouse hybrid cells susceptible to infection with poliomyelitis types i, ii, iii, echo type 1 and 12, and coxsackie a7 viruses have been derived. the presence in the hybrid cells of 2 and 3 genomes of the nonpermissive cell partner (mouse) was shown not to inhibit enterovirus reproduction. hybrid cultures differed in their sensitivity to the mutagenic action of poliomyelitis virus. there was no correlation between poliomyelitis virus yield and the number of chromosome breaks in hyb ...19846093387
myocarditis and cardiomyopathy.with more widespread application of emb techniques, a significant percentage of iccm patients have been found to have lymphocytic myocarditis on biopsy. it is now appreciated that patients with myocarditis may also present with isolated abnormalities of left ventricular diastolic function, dysrhythmias, and/or complaints of chest discomfort with normal coronary angiograms. epidemiologic and serologic data incriminate a viral etiology underlying many cases of acute myocarditis and iccm. although ...19846093491
elution of enteric viruses from mississippi estuarine sediments with lecithin-supplemented eluents.isoelectric casein supplemented with lecithin was tested for its ability to recover enteric viruses from estuarine sediments of varied sand, silt, and clay composition. recoveries were higher when lecithin was incorporated into an eluent as compared with trials with only the casein solution. semipurified soybean lecithin (3%) allowed the highest overall recovery of virus from all sediments tested; crude soybean lecithin produced the lowest recovery. a difference in the percentage of virus able t ...19846093692
agarose isoelectrofocusing of intact virions.a convenient and accurate method for determining the isoelectric points of intact virions is described. tritium-labeled poliovirus 1 (strains brunhilde and lsc-2) and echovirus 1 (isolates v239, v248, v212, r115 and 4ch-1) were successfully focused into sharp bands at their respective isoelectric points using a thin-layer agarose isoelectric focusing system. in situ detection of labeled virus bands in the agarose was by fluorography. freezing and thawing of virus samples prior to isoelectric foc ...19846094606
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