| a stochastic assembly model for nipah virus revealed by super-resolution microscopy. | understanding virus assembly mechanisms is important for developing therapeutic interventions. nipah virus (niv) is of interest because of its high mortality rate and efficient human-human transmissions. the current model for most enveloped viruses suggests that matrix proteins (m) recruit attachment glycoproteins (g) and fusion glycoproteins (f) to the assembly site at the plasma membrane. here we report an assembly model that differs in many aspects from the current one. examining niv proteins ... | 2018 | 30076303 |
| sendai virus v protein inhibits the secretion of interleukin-1β by preventing nlrp3 inflammasome assembly. | inflammasomes play a key role in host innate immune responses to viral infection by caspase-1 (casp-1) activation to facilitate interleukin-1β (il-1β) secretion, which contributes to the host antiviral defense. the nlrp3 inflammasome consists of the cytoplasmic sensor molecule nlrp3, adaptor protein asc, and effector protein pro-caspase-1 (pro-casp-1). nlrp3 and asc promote pro-casp-1 cleavage, leading to il-1β maturation and secretion. however, as a countermeasure, viral pathogens have evolved ... | 2018 | 30021903 |
| nipah virus in kerala: a deadly zoonosis. | | 2018 | 29935330 |
| nipah virus control needs more than r&d. | | 2018 | 29900857 |
| enhancing preparation for large nipah outbreaks beyond bangladesh: preventing a tragedy like ebola in west africa. | the nipah virus has been transmitted from person-to-person via close contact in non-urban parts of india (including kerala may 2018), bangladesh, and the philippines. it can cause encephalitis and pneumonia, and has a high case fatality rate. nipah is a one health zoonotic infectious disease linked to fruit bats, and sometimes pigs or horses. we advocate anticipating and preparing for urban and larger rural outbreaks of nipah. immediate enhanced preparations would include standardized guidance o ... | 2018 | 29879523 |
| sixty seconds on . . . nipah virus. | | 2018 | 29871862 |
| nipah virus outbreak in india. | | 2018 | 31876482 |
| [research progress in enveloped glycoproteins and the membrane-fusion mechanism of nipah virus]. | nipah virus (niv) is the pathogen of an emerging zoonotic disease that is highly lethal and infectious. niv seriously impacts human lives and the property in the epidemic areas and poses a great threat to the global public health security. this paper provides a brief introduction to the morphological structure, and physiological function of the attachment protein g and the fusion protein f, which are both crucial glycoproteins located on the surface of the virus envelope. moreover, recent advanc ... | 2016 | 29963835 |