| [effect of the ionic form of cationite on influenza virus sorption]. | | 1979 | 530114 |
| the epidemiology of influenza in canada, 1977-78. | | 1979 | 546507 |
| effect of influenza infection on the phagocytic and bactericidal activities of pulmonary macrophages. | the effect of mouse-adapted influenza a/pr/8/34 virus on pulmonary macrophage function was evaluated by using an in vitro system which allowed direct virus interaction with macrophages and then separate analysis of the steps required for bacterial clearance by macrophages. infection of macrophages with this virus resulted in the appearance of a hemagglutinating activity on the macrophage surface; expression of this activity was inhibited by amantadine, 2-deoxyglucose, and cycloheximide and by pr ... | 1979 | 546791 |
| [morphometric study of the bronchopulmonary lymphoid system in the normal mouse and the mouse infected with influenza virus]. | morphometric study of mouse bronchus-associated lymphoid tissue (balt) using an image analyser and histological sections at close and regular intervals was carried out in lungs of control and influenza infected mice two to three months old. the mean area of balt did not reach 0,1 p. 100 of the whole mean area of examined lung sections in control mice; this percentage was significantly greater one month after primary exposure to influenza virus. | 1979 | 547752 |
| surveillance of the antibody status to current influenza strains in the norwegian population. 1: method of serum sampling and evaluation of the a/ussr/77 (h1n1) impact in various age groups in 1978. | every autumn approximately 900 randomly selected sera from various regional bacteriological laboratories are received at the niph and assayed for the presence of haemagglutination-inhibition antibodies to current influenza strains. after three years of preliminary investigations the system is now working successfully. it is possible, in retrospect, to assess the impact of various influenza strains in different age groups and regions of the country. in particular, after the reappearance of the h1 ... | 1979 | 548838 |
| an association between sub-arachnoid haemorrhage and influenza a infection. | the sera of 25 patients with confirmed sub-arachnoid haemorrhage were assayed by complement fixation for 14 viruses. twenty (80%) showed elevated titres to influenza a virus compared with 3 out of 25 (12%) of control subjects matched for age, sex and district and 3 out of 17 (17%) of a group of patients with other neurological disorders. a seasonal variation in the notification of sub-arachnoid haemorrhage appeared to be related to changes in the incidence of influenza a infection. | 1979 | 548946 |
| [effect of plant extracts on the growth of influenza viruses. i. effect of plant extracts on the growth of influenza viruses in cultures of chick embryo fibroblasts and in chick embryos]. | | 1979 | 549452 |
| [isolation of influenza virus in tucuman--1976]. | | 1979 | 550224 |
| [recirculation of influenza a virus (h1n1). the epidemic of january-march 1979 in moldavia]. | | 1979 | 550251 |
| [preparation of an influenza vaccine from allantoic viral cultures inactivated with uv irradiation]. | | 1979 | 550532 |
| [obtaining a lyophilized preparation of inactivated influenza vaccine]. | | 1979 | 550533 |
| [characteristics of measuring the neuraminidase activity and total protein in influenza virus preparations of an allantoic nature]. | | 1979 | 550537 |
| [effect of parenteral vaccination on the characteristics of experimental influenza in mice]. | | 1979 | 550540 |
| [effect of the vaccination method on the level of protection from influenza infection in mice]. | | 1979 | 550541 |
| [change in the proliferative activity of mouse splenocytes under the influence of native and inactivated influenza virus]. | | 1979 | 550542 |
| [influenza epidemic process as a self-regulating system]. | | 1979 | 550544 |
| [obtaining concentrated influenza virus preparations by adsorption liquid chromatography]. | | 1979 | 550554 |
| influenza surveillance. serological trends in military recruits, 1978-1979. | | 1979 | 550721 |
| guillain-barré syndrome: the swine influenza virus vaccine incident in the united states of america, 1976-77: preliminary communication. | | 1979 | 552571 |
| [serologic survey of human type a influenza virus infection following 10-year periods of prevalence of h3n2 strains]. | distribution of h.i.a. against a/new jersey/8/76 (hsw1n1), a/pr/8/34 (h0n1), a/fm/1/47 (h1n1), a/japan/305/57 (h2n2) influenza virus strains was determined in 553 serum samples, previously tested for a/hong kong/1/68 virus, collected in the late summer of 1977 in milan and bari. for all variants, distinctive antibody patterns were obtained which reflect periods of prevalence of these viruses in man. so, the peak of positivity and the higher h.i.a. levels were found for a/new jersey/8/76 strain i ... | 1979 | 552822 |
| [studies on the biological characteristics of the new type a1 influenza virus]. | | 1979 | 552966 |
| [circulation of three types of influenza a virus in the roman population during the winter of 1977-78]. | | 1979 | 554129 |
| [vaccination against influenza (author's transl)]. | the author refers to the problems of vaccination against influenza with regards to the most recent epidemiological and clinical acquisitions. | 1979 | 554553 |
| [epidemiology of influenza viruses in trieste during the winter of 1977-1978]. | | 1979 | 554620 |
| [influenza in umbria from september 1977 to may 1978]. | from september 1977 through may 1978 a research project was conducted to determine the presence of haemagglutination inhibiting antibodies (h.i.a.) on three influenza viruses: a/victoria/3/75, a/urss/90/77 and b/hong kong/8/73. participating in the project were 1066 persons residing in the region of umbria, italy, ages ranging from 0- - 60. the results obtained showed the possibility of diffusion in umbria of all three of the strains studied due to the low protective levels found in the particip ... | 1979 | 554621 |
| influenza epidemiology in genoa between 1975 and 1978. | | 1979 | 554622 |
| [outbreak of equine influenza caused by a new strain of equine myxovirus subtype 2. i. etiology]. | during an outbreak of acute respiratory disease in algeria, a strain of equine influenza virus was isolated. this strain, a/equine/algiers/72, bears an important antigenic drift from the prototype strain a/equine/miami/1/63, but is closely related to a strain isolated in 1971 in japan (a/equine/sachiyama/1971). | 1977 | 555280 |
| [outbreak of equine influenza by a new strain of myxovirus type 2. ii. epizootiology]. | during an epizootic of equine acute respiratory disease in algeria, a strain of equine influenza virus was isolated. sera examination by hemagglutinin inhibition test and complement fixation test confirmed the etiology of the disease. the first and second outbreak of the disease remained localised. the third outbreak spread within few months to all parts of the country. horses vaccinated with a commercial equine influenza vaccine remained healthy. | 1977 | 555281 |
| serological investigations on the circulation of an influenza virus a(h1n1) strain in swine and horses. | | 1979 | 556169 |
| studies on the inhibitory effect of lectins on myxo-virus release. | lectins of different specificities do not interfere with the maturation of myxo-viruses; their inhibitory effect on virus replication is mainly due to prevention of the detachment of infectious virus particles from the host cell. in chick embryo fibroblasts infected with an influenza virus and treated with concanavalin a, budding occurs into intracytoplasmic vacuoles, but this phenomenon is not observed with a parainfluenza virus and with different cells. | 1977 | 558281 |
| influenza virus infection of a cell-cycle mutant of chinese hamster ovary cells. | | 1977 | 558282 |
| cell-free coupling of influenza virus rna transcription and translation. | a cell-free coupled system for the transcription and translation of fowl plague virus rna is described. the system utilizes a new nuclease-preincubated rabbit reticulocyte lysate that has a high sensitivity to exogenous mrna and a very low level of nuclease activity. translation of the viral proteins in the coupled system is strictly dependent upon the viral transcriptase activity. in the coupled system the optimal concentration of magnesium is intermediate between the optimum for transcription ... | 1977 | 559102 |
| method for assigning temperature-sensitive mutations of influenza viruses to individual segments of the genome. | | 1977 | 560753 |
| [circulating and secretory antibodies in mice after administration of influenza virus by various routes]. | | 1979 | 544981 |
| [characteristics of influenza virus depending on temperature of replication]. | | 1979 | 544982 |
| the m protein of influenza viruses has no immunizing effect. | influenza a virus m protein was prepared by electrophoresis in sds polyacrylamide gel from virus particles which had been pretreated with octylglucoside to remove the surface glycoproteins; m antigens from the influenza virus strains a/victoria/3/75 (h3n2), a/fpv/rostock (hav1n1) and a/chick/germany/49 (hav2neq1) did not protect mice against a lethal challenge infection with the virulent victoria strain. | 1979 | 545115 |
| characterization of virus-specific messenger rnas from avian fibroblasts infected with fowl plague virus. | in cell-free protein synthesizing systems from wheat embryos, messenger rnas extracted from chick embryo fibroblasts infected with fowl plague virus direct the synthesis of nine virus-specific polypeptides, two of which may be related to the virus-specific glycopolypeptides. all of the mrnas are complementary in sequence to virion rna, and rnas which do not contain poly a appear to be translated as efficiently as their polyadenylated counterparts. under certain conditions of incubation, virion r ... | 1977 | 561162 |
| synthesis of influenza virus polypeptides in cells resistant to alpha-amanitin: evidence for the involvement of cellular rna polymerase ii in virus replication. | influenza virus polypeptides were not synthesized in wild-type cho-s-infected cells in the presence of alpha-amanitin, but were synthesized in cho-amal cells, a mutant cell line whose dna-dependent rna polymerase ii is specifically resistant to this drug, indicating that this cellular enzyme is involved in influenza virus replication. the results of experiments designed to detect viral polypeptides synthesized from primary transcripts suggest that the synthesis of a cellular rna species by rna p ... | 1977 | 561196 |
| ocular abnormalities after influenza immunization. | | 1977 | 561590 |
| virulence factors of influenza a viruses: wsn virus neuraminidase required for plaque production in mdbk cells. | the genetic basis for the distinctive capacity of influenza a/wsn/33 (h0n1) virus (wsn virus) to produce plaques on bovine kidney (mdbk) cells was found to be related to virus neuraminidase. recombinant viruses that derived only the neuraminidase of wsn virus were capable of producing plaques, whereas recombinant viruses identical to wsn except for neuraminidase did not produce plaques. with viruses that do not contain wsn neuraminidase, infectivity of virus yields from mdbk cells was increased ... | 1977 | 561860 |
| replication of animal viruses in differentiating muscle cells: influenza virus a. | cells were cultured from the breast muscle of 11- to 12-day-old chick embryos and were grown under conditions optimal for the development of the cells into terminally differentiated, fused myotubes. myotubes were infected with influenza virus a/ann arbor/6/60(h2n2) at high multiplicity, and synthesis of virus-specific proteins and rnas was detected by haemadsorption, fluorescence microscopy and/or isotope labelling and electrophoresis techniques. provided that myotubes were maintained at tempera ... | 1977 | 562389 |
| stereo surface replicas of culture cells for high-resolution electron microscopy. | | 1977 | 562418 |
| effect of nitrogen dioxide on influenza virus infection in hamster trachea organ culture. | | 1977 | 563599 |
| on the mechanism of inhibition of influenza virus replication by amantadine hydrochloride. | the results of analyses of fowl plague virus-specific rna and protein synthesis in infected chick embryo fibroblasts incubated in amantadine hydrochloride are reported. they indicate that provided amantadine is present from the time of virus addition no expression of the virus genome occurs and that the synthesis of even the first detectable transcripts catalysed by the polymerase of the infecting virus particles is prevented. in agreement with previous reports it is concluded that amantadine pr ... | 1978 | 563896 |
| [parent structures of influenza virus in infected cells]. | the fate of influenza virus (a/fpv/weilbridge) parental structures was studied in permissive (chick fibroblasts) and nonpermissive (ehrlich ascitic carcinoma cells) cell systems. the cells were infected with the virus labeled with 3h-precursors of rna of the pulse label and by polymerase reaction in vitro. in the cytoplasm, the functionally active parental structures were found in the area of nucleocapsids (40-50 s). upon recentrifugation in cesium chloride gradient, some of these structures sho ... | 1977 | 564099 |
| viral antigens and impurities in influenza vaccines. evaluation by immunoelectrophoretic methods. | laurell electrophoretic methods were used to evaluate internal influenza virus antigens and immunogenic impurities (from the fertile egg) in influenza whole virus and subunit preparations. it could be found that subunit preparations obtained after selective solubilization of the surface antigens with cetyltrimethylammoniumbromide are essentially free from internal structure proteins, ribonucleoprotein, and matrix protein. in addition impurities (non viral antigen substances) are considerably red ... | 1977 | 564309 |
| experience with monovalent and bivalent influenza vaccines in canada 1976. | laboratory examination of vaccines from four manufacturing companies and prepared with a/new jersey/8/76 and a/victoria/3/75 strains (clinical results, cf. these proceedings, pp. 267-272). when diluting the concentrated suspensions of vaccine, loss of activity can be avoided by adding a small amount of tween 80 to the diluent. | 1977 | 564310 |
| swine-like influenza virus infection in a wisconsin farm family. | | 1977 | 564374 |
| overview of clinical trials of influenza vaccines, 1976. | | 1977 | 564375 |
| safety of influenza vaccination in allergic children. | one hundred forty-two allergic children aged three to 18 years were studied for evaluation of the usefulness of skin testing with influenza vaccine as a means of identifying those children who could be immunized safely despite their allergies to chickens, eggs, or feathers. one hundred twenty-eight children were fully immunized with bivalent influenza a/new jersey/76-a/victoria/75 vaccine. twelve children had positive skin tests and were not immunized, and two developed positive skin tests after ... | 1977 | 564376 |
| description of a technique for the analysis of antineuraminidase antibodies oriented to h2n2 and h3n2 influenza virus strains. | a method for the analysis of mixtures of antineuraminidase (an) antibodies oriented to antigenically different neuraminidases of h2n2 and h3n2 influenza virus strains is described. the method is based on the finding that the different classes of an antibodies give different titer ratios when reacting with the recombinants a/bel/42 (h0)-a/sing/1/57 (n2) and a/equine/prague/1/56 (heg1)-a/hong kong/1/68 (n2) and a mixture of both recombinants. these titer ratios are determined under the experimenta ... | 1978 | 564681 |
| application of the egg-bit technique in poultry-disease research. | experiments were carried out to determine the usefulness of the egg-bit technique (ebt) in poultry virus research with various agents available on the market. the ebt was found satisfactory for propagating 9 strains of avian influenza virus of different antigenic groups, with only minor differences resulting when the procedure used two sources of gelatin, presence or absence of cacl2, or commercial or specific-pathogen-free embryos. | 1977 | 564687 |
| radioimmunoprecipitation assay for quantitation of serum antibody to the hemagglutinin of type a influenza virus. | a double-antibody radioimmunoprecipitation (rip) assay has been developed to provide a sensitive and specific measure of antibody to hemagglutinins of h3n2 influenza viruses. chloramine t was used to radiolabel purified hemagglutinins to high specific activity without loss of antigenicity. the purity of the labeled hemagglutinin was confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis, which also established that both the ha(1) and ha(2) polypeptides were iodinated. radiolabele ... | 1978 | 564916 |
| [effect of the influenza virus and its structural components on the animal immunocompetence system]. | the authors studied the effect of the influenza virus a (pr8/34) and of its structural components on the immunological reactivity of mice. the enzyme of the external coat of the influenza virus--neuraminidase--possessed an immunodepressive action. administration of neuraminidase led to the elimination of sialic acids from the surface of lymphocytes and to the reduction of their electrophoretic mobility. the mechanism of the immunodepressive action of neuraminidase is discussed. | 1978 | 566139 |
| recurrent guillain-barré syndrome following influenza vaccine. | two patients recovered from an attack of guillain-barré syndrome and then had a second attack of this disease, with a shorter latent period, following monovalent influenza vaccination. these cases suggest that an attack of guillain-barré syndrome may result in greater risk of future episodes of the syndrome in conjunction with exposure to influenza or other vaccinations. | 1978 | 566873 |
| investigations on the involvement of swine influenza a virus (hsw1n1) in the influenza outbreak recorded in a town of romania during the 1976--1977 winter season. | seroepidemiological investigations performed with 1,620 serum samples and serodiagnostic tests with 166 paired sera demonstrated that swine influenza virus type a/new jersey 8/76 (hsw1n1) played no role in the epidemiology of human influenza in a large town of romania during 1977. | 1978 | 567886 |
| effects of sialylation of influenza virions on their interactions with host cells and erythrocytes. | | 1978 | 567887 |
| [intranuclear centers of influenza virus reproduction during the early stage of infection]. | at 1--3 hours after infection of chick fibroblasts and a continuous dog kidney cell line mdck with wsn and fpv viruses large virus specific structures were found containing parent nucleocapsids, newly synthesized virus-specific rna and newly synthesized protein. the buoyant density of these structures in cesium chloride was 1.30--1.32 g/ml. the amount of newly synthesized rna and protein in these structures increased linearly for 3 hours of infection. the parent and newly synthesized rna in the ... | 1978 | 567891 |
| [effect of ribovirine (1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboximide) on rna-dependent rna-polymerase induction and virus-specific polysome formation in cell cultures infected with influenza a virus]. | | 1978 | 568351 |
| experimental investigation of changes in the antigenic structure of influenza viruses during their persistence. | systems of persistent influenza infection produced in the cultures of human embryonal kidneys and in the diploid cells of human embryonal lungs under the effect of a/hong-kong/1/68 and a/victoria/35/72 viruses were characterized. the cell systems were studied in the course of 4--3u passages, i. e., from 40 to 289 days. a total of 102 viruses were isolated during the period of observation, out of which 44 were examined for the antigenic profile of ha and na. the antigenic structure of the initial ... | 1978 | 569169 |
| dna sequences in influenza virions. | during the propagation of a (h3n2) influenza virus in chick embryos, incorporation of 3h-thymidine into virions takes place, whereas no such incorporation occurs with newcastle disease virus. incorporation of 3h-thymidine is a result of dna synthesis. this virion-associated dna is present in cores obtained after treatment of virions with bromelain. | 1978 | 569183 |
| growth of some attenuated influenza viruses in hamster tracheal organ cultures. | hamster tracheal organ cultures were infected with different influenza viruses and the metabolic activity measured using a tetrazolium reduction assay. in addition, relative ciliary activity was observed, virus multiplication measured, and histological studies were made. the hamster organ cultures proved relatively simple to set up and were sensitive to infection with influenza viruses; and the tetrazolium reduction was a reliable objective measure of relative tissue damage correlating well with ... | 1978 | 569249 |
| host range recombinants of fowl plague (influenza a) virus. | | 1978 | 569394 |
| influence of the infection with lipid-containing viruses on the metabolism and pools of phospholipid precursors in animal cells. | the influence of infection with three different lipid-containing rna viruses, newcastle disease virus, fowl plague virus, and semliki forest virus on the phosphatidylcholine precursors of chick embryo cells and of baby hamster kidney (bhk) cells has been measured. in chick embryo cells infection with newcastle disease virus does not influence the energy charge, or the distribution and absolute pool sizes of the precursors or the choline phosphotransferase activity. in chick embryo cells infected ... | 1978 | 569579 |
| host defense mechanisms against influenza virus: interaction of influenza virus with murine macrophages in vitro. | the interaction of mouse macrophages with influenza virus was examined as part of a study into the defense mechanisms against influenza infection. macrophages exposed to a/port chalmers/1/73 virus produced infectious foci on susceptible indicator cell monolayers. sampling of supernatant fluids and cells from infected macrophage cultures showed release of virus adsorbed to the cell surface. active virus replication in macrophages could not be demonstrated. exposing macrophages to specific antibod ... | 1978 | 569645 |
| [electronoptical studies of the effect of 1-[p-(methylnitrosamino)-benzylidenamino]-adamantane on the fowl plague virus (fpv) in cell culture]. | the adamantanamine derivative 1-[p-(methylnitrosamino)-benzylidenamino]-adamantane (mbaa) at a concentration of 40 microgram/ml demonstrated no effect on adsorption of fowl plague virus (fpv) on chick embryonal cells. the penetration of the virions took place by means of pinocytosis. in the final stages of penetration the virions became gradually disintegrated. under the influence of mbaa, after break-down of the membrane of pinocytic vesicles a swollen part of the virus core remained in cytopla ... | 1978 | 569933 |
| [aggregation and deformation of virions and subviral structures of influenza virus type a in interaction with antibodies]. | | 1978 | 571174 |
| influenza and myoglobinuria in brothers. | two adult brothers became ill within 48 hours of each other, and both had severe myoglobinuria. one brother died of oliguric renal failure. the other did not have renal failure and survived. acute influenza a infection was documented serologically and from throat washings in the surviving brother, and by isolation of the influenza a virus from throat cultures and lung tissue of the brother who died. it is not certain whether a genetic myopathy made these brothers susceptible to viral-induced myo ... | 1979 | 571980 |
| the coupling of transcription from influenza virions to translation in vitro. | the optimum conditions for the coupling of fowl plague virus (fpv) transcription to an in vitro reticulocyte translation system have been established and shown to be close to those required for maximum rna synthesis by purified fpv virions. products have been characterized by the peptides they yield on limited proteolysis in sds and it has been shown that virus nucleoprotein (np) and matrix (m) protein are made. the smallest virus coded polypeptide, the non-structural protein (ns), is made in on ... | 1979 | 572213 |
| nucleotide sequence coding for the n-terminal region of the matrix protein influenza virus. | after polyadenylation in vitro of the influenza virus rna segment which contains the coding information for the matrix protein, a cdna copy can be made using the primer p(dt)8-da and reverse transcriptase. the sequence of 166 nucleotides of the cdna was determined by a modification [brownlee, g. g. & cartwright, e. m. (1977) j. mol. biol, 114, 93--117] of the plus/minus method [sanger, f. & coulson, a. r. (1975) j. mol. biol. 94, 441--481] and adaptation of the "dideoxy" method [sanger, f., nick ... | 1979 | 572297 |
| replication of two influenza virus strains and a recombinant in hef and lep cells. | the replication of influenza viruses a/nws-d, a/ws-mk and their r12 recombinant in human embryo fibroblast (hef) and human diploid fibroblast (lep) cell lines was studied. in hef cells virus nws-d and recombinant r12 induced synthesis of virus-specific macromolecules and produced infectious virions; virus ws-mk induced synthesis of virus complementary rna (crna), virion rna (vrna), protein, rnp and non-infectious virions, but haemagglutinin cleavage was impaired and the virions formed contained ... | 1979 | 574155 |
| transplacental transmission and neonatal infection with swine influenza virus (hsw1n1) in swine. | to study the question of chronicity or latency of swine influenza virus (hsw1n1) infections in swine, newborn pigs were exposed to the virus in two experiments, and pregnant gilts were exposed in another experiment. of five pigs exposed at 5 days of age, virus was isolated from throat swab samples of all (up to 10 postexposure days (ped) in one pig) and from a blood sample from one pig on ped 1 and 3. virus was not isolated from urine, tissues, or explants of organs from pigs euthanatized ped 20 ... | 1979 | 575027 |
| a study on the role of birds in the spread of infections. | during three expeditions undertaken in march 1977 to june 1978, 797 cloacal swabs were collected from birds of 54 species. seven salmonella strains of six serotype were isolated from larus ridibundus (five strains), corvus frugilegus and acrocephalus schoenobaenus (one each). four strains of influenza a (hav2 na4v) virus were isolated from larus ridibundus. for the first time in czechoslovakia, two strains of yucaipa paramyxovirus were isolated, both of them from troglodytes troglodytes. these r ... | 1979 | 575902 |
| influenza pandemics in perspective. | | 1977 | 576459 |
| influenza: vaccines or amantadine? | | 1977 | 576634 |
| mortality from pneumonia and risk conditions during influenza epidemics. high influenza morbidity during nonepidemic years. | increases in mortality from pneumonia and high-risk chronic diseases have not occurred during recent influenza epidemics. excess mortality during the past four influenza epidemics in the united states is attributable to influenza reported as a primary cause of death, and the average excess was only about 4,000 deaths per epidemic. most clinical influenza severe enough to cause hundreds of millions of days of bed disability during nonepidemic as well as epidemic years is not caused by the influen ... | 1977 | 577246 |
| influenza a infection simulating pulmonary embolism. | the diagnosis of pulmonary embolism is generally established when the patient has characteristic pulmonary perfusion abnormalities in the setting of an appropriate clinical history and with no concurrent cardiopulmonary disease on chest x-ray film. the initial evaluation, including positive pulmonary perfusion scan, of four young black women suggested the diagnosis of pulmonary emboli. a syndrome of respiratory tract viral infection then developed, and further evaluation by angiography and perfu ... | 1977 | 578163 |
| [homologous and heterologous antibody induction in influenzal infection and immunization]. | serological examinations were carried out in 72 patients with influenza and 384 volunteers immunized with a vaccine from different strains of influenza a virus. a high level of antibody (greater than 1:64) was found to protect against influenza infection by a homologous strain as well as strains with certain immunologic affinity in the main virus structures, hemagglutinin and neuraminidase. | 1977 | 579009 |
| the localization of influenza virus in the respiratory tract of ferrets: the importance of early replication events in determining tissue specificity. | | 1977 | 579185 |
| effects of individual inhalation of aerosolized amantadine hydrochloride in mice infected with influenza virus a/bethesda 10/63 (h2n2) and a/hong kong 1/68 (h3n2). | | 1979 | 582762 |
| antibody response to monovalent a/new jersey/8/76 influenza vaccine in pregnant women. | the decision to implement a mass immunization program with a/new jersey/8/76 (hsw1n1) influenza vaccine provided a unique opportunity to evaluate immunological responses during pregnancy. fifty-nine pregnant and 27 nonpregnant women participated in this study. influenza virus hemagglutination-inhhibition antibody titers were determined to a/new jersey/8/76 (hsw1n1), a/japan/305/57 (h2n2), and a/hong kong/8/68 (h3n2) before and after a single dose of monovalent (200 chick cell agglutination units ... | 1979 | 583151 |
| [effect of thiazolinone-4 derivatives on the course of experimental viral and malignant diseases]. | | 1979 | 583357 |
| a single gene determines the host range of influenza virus. | | 1977 | 593388 |
| [study of antibodies to the influenza virus a2 in the tears of patients with keratitis]. | | 1977 | 593642 |
| depression of rat neutrophil exudation and motility by influenza virus. | purified influenza a and b viruses (3000 ha units) were injected intraperitoneally into rats. 1 h later the animals were given starch solution intraperitoneally, after which the number and composition of the exuded cells were determined at intervals. both influenza a and b viruses depressed neutrophil exudation into the peritoneal cavity for a period of 10 to 17 h after the starch injection. the exudation of leukocytes other than neutrophils (a mixture of mononuclear cells and 5% to 10% eosinoph ... | 1977 | 594666 |
| [determining the intensity of circulation and variability of influenza virus by the presence and dynamics of antihemagglutinins in placental gamma globulins]. | | 1977 | 595549 |
| cold adapted variants of influenza a. ii. comparison of the genetic and biological properties of ts mutants and recombinants of the cold adapted a/aa/6/60 strain. | the genetic and biological properties of 13 recombinant influenza a clones derived at 25 degrees c from the a/aa/6/60-cold variant (by crosses with 4 different wild type strains) were compared with a set of 5-fu induced ts-mutants. the 5-fu mutants had previously been placed into 7 complementation-recombination groups; the a/aa/6/60-cold parent (pi-7) and the 12 cold recombinant clones which were ts were shown to share a lesion with only one of these groups. the parental strain and 5 recombinant ... | 1977 | 597038 |
| [studies of influenza in palermo, 1970-75]. | epidemiological surveillance of influenza was carried out in palermo betwen 1970 and 1975. antigenic structure of viral strains a/h3n2 isolated from influenza patients during winter outbreaks was studied in comparison with reference strains circulating in the same periods in other parts of the world. antigenic drift of hemagglutinin, of neuraminidase, or of both, was observed in palermo isolates, which were progressively different from hong kong/68 strain; 1973 and 1975 isolates were similar to ... | 1977 | 597390 |
| [optimal temperature of enzyme activity and heat resistance of neuraminidases as attenuation markers for influenza viruses]. | neuraminidase activity of virulent and vaccinal strains a/england/42/72, a/scotland/840/74 and a/victoria/3/75 assessed at different temperatures did not show significant differences in the temperature optima of enzyme activity. vaccinal strains were attenuated by apr-8 recombination and selection of mutants resistant to serum inhibitors (alice, rit 4025, rit 4050 strains). on the contrary, differences were found in the thermal inactivation of the neuraminidase between wild and vaccinal strains, ... | 1977 | 597391 |
| serum igm antibody and influenza a infection. | sucrose density gradient ultracentrifugation followed by haemagglutination inhibition for demonstrating specific influenza igm was evaluated as a means of confirming recent infection with influenza a viruses. specific igm antibodies were found in at least one serum obtained from 83% of patients with proven recent infection with influenza a viruses but in none of the sera from 21 individuals without evidence of infection. influenza igm antibodies persisted for up to 112 days after infection. the ... | 1977 | 599186 |
| the structural basis of the function of influenza virus glycoproteins. | | 1977 | 600203 |
| influenza--a review for clinicians. | | 1977 | 600255 |
| studies with live attenuated influenza virus in chronic bronchitis. | the use of live, recombinant virus for immunisation against influenza produced a number of respiratory illnesses, some severe, in patients with chronic obstructive airways disease. these patients are probably more susceptible to the influenza virus than are normal subjects. special care will be needed in testing these viruses on patients with respiratory disease. | 1977 | 601735 |
| [isolation of type b/hong kong/5/72 and type a/port chalmers/1/73 (h3n2) influenza viruses in quebec in 1974]. | | 1977 | 603860 |
| clinical acceptability of live influenza vaccine in high risk subjects and children. experience with three consecutive recombinant strains. | reactogenicity and immunogenicity of three recombinant strains, alice, rit 4025 and rit 4050, were re-examined by a retrospective analysis of the data from clinical trials and routine vaccination campaigns. special emphasis was put on the acceptability of vaccinal strains for the elderly, patients with chronic pulmonary diseases, subjects with atopy and children, as well as on the safety of repeated administrations of the vaccine to the general population. the incidence and nature of postvaccina ... | 1977 | 604091 |
| rna-rna hybridization between influenza viruses. | a study is described of the rnas of recombinant viruses made from a/pr/8/34, which is non-infectious for man, and wild human influenza a strains. by rna-rna hybridization it was possible to determine the proportion of the genome donated by each of the parents. the technique can be applied as a biochemical marker to detect the recombinants among parental viruses and moreover, it is a method to select the attenuated viruses among the recombinants. | 1977 | 604092 |
| live influenza vaccine in patients with chronic bronchopulmonary diseases. a multicenter study with two consecutive vaccinal strains. | live influenza vaccines rit 4025 and rit 4050, containing the recombinants of a/scotland/840/74 and a/victoria/3/75 with a/pr/8/34 virus respectively, were administered during the vaccination campaigns 1975-76 and 1976-77 to patients with established chronic bronchopulmonary diseases. the study was designed to assess the clinical acceptability of these vaccinal strains and to measure the effects of vaccination on pulmonary function in this population. clinical and respiratory function findings w ... | 1977 | 604093 |
| studies of respiratory function in volunteers given live influenza virus vaccine. | measurements of peak flow, vital capacity, fev1 and flow volume studies were performed in healthy volunteers for 20 weeks following intranasal vaccination with live-attenuated a/victoria/3/75 recombinants or placebo. despite differing attenuation of the two candidate strains, no effect on pulmonary function was detected. | 1977 | 604095 |
| procedures for characterisation of the genetic material of candidate vaccine strains. | two procedures for characterising the genomes of recombinant influenza viruses are described. the first of these involves ribonuclease t4 oligonucleotide fingerpart analysis of separated viral rnas labelled either in vivo or in vitro and the second utilises polyacrylamide gel electrophoresis to identify the double-stranded molecules formed by hybridisation between the complementary and virion rnas of two viruses. although the latter method is more suitable for routine screening purposes, both pr ... | 1977 | 604097 |
| the assay of influenza virus structural antigens in vaccines by rocket immunoelectrophoresis. | the internally situated influenza virus structural antigens (matrix and nucleoprotein) and the glycoprotein hemagglutinin were assayed using rocket immunoelectrophoresis or single radial diffusion following disruption of purified virus with 1% w/v sodium sarcosyl detergent. electrophoresis was carried out for 1-4 h in 0.05 m barbitone buffer at ph 8.6. the potency estimations of ha and m activity were similar for the two methods for bivalent beta-propiolactone inactivated whole virus vaccines. | 1977 | 604098 |