| impairment of salicylate uptake from rat small intestine following pretreatment with a folic acid antagonist. | | 1976 | 6686 |
| the narcotic discriminative stimulus complex: relation to analgesic activity. | the ability of drugs to produce the narcotic discriminative stimulus complex is found to be highly correlated with their analgesic activity; in contrast, no relation with their antidiarrhoeal activity is evident. the findings suggest that the narcotic discriminative stimulus complex is a centrally mediated effect of narcotic drugs. | 1976 | 6689 |
| localization of dopamine receptors in the rat cerebral cortex. | | 1976 | 6700 |
| circling behaviour produced by asymmetric medial raphé nuclei lesions in rats. | | 1976 | 6702 |
| limiting factors in the antagonism of neuroleptics on dopamine-sensitive adenylate cyclase. | | 1976 | 6703 |
| antiacetylcholine activities of psychoactive drugs: a comparison of the 3hquinuclidinyl benzilate binding assay with conventional methods. | | 1976 | 6704 |
| noradrenergic influence on the stereotyped behaviour induced by amphetamine, phenethylamine and apomorphine. | | 1976 | 6705 |
| pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (-)-isomer. | | 1976 | 6706 |
| accumulation of cgmp in striatum of rats injected with narcotic analgesics: antagonism by naltrexone. | | 1976 | 6708 |
| the kinetics of enzyme action and inhibition in intact tissues and tissue slices, with special reference to cholinesterase. | | 1976 | 6713 |
| identification of monohydroxylated metabolites of cannabidiol formed by rat liver. | cannabidiol (cbd) was metabolized in vitro by rat liver enzymes. unchanged cbd and eight monohydroxylated metabolites were isolated and positively identified. as previously reported, 7-hydroxy-cbd was the major metabolite. the second most abundant metabolite was 6alpha-hydroxy-cbd; whereas only a trace amount of 6beta-hydroxy-cbd was found. in addition hydroxylation occurred in all positions of the pentyl side chain, 4 inches-hydroxy-cbd being most abundant. 3 inches-hydroxy-cbd was formed in ha ... | 1976 | 6714 |
| benzodiazepines: gaba and glycine receptors on single neurons in the rat medulla. | | 1976 | 6725 |
| effects of lilly 110140, a specific inhibitor of 5-hydroxytryptamine uptake, on food intake and on 5-hydroxytryptophan-induced anorexia. evidence for serotoninergic inhibition of feeding. | | 1976 | 6727 |
| correlation between neuroleptic-induced suppression of stereotyped behaviour and hva concentrations in rat brain. | | 1976 | 6728 |
| a simple superfusion technique for studying release of radiolabelled 5-hydroxytryptamine from blood platelets without interference of reuptake. | | 1976 | 6729 |
| contraversive circling behaviour produced by unilateral electrolytic lesions of the ventral noradrenergic bundle mimicking the changes seen with unilateral electrolytic lesions of the locus coeruleus. | | 1976 | 6733 |
| catecholamines then and now. | | 1976 | 6738 |
| catecholamines in blood. | | 1976 | 6739 |
| sympathomimetic bronchodilators and animal models for assessing their potential value in asthma. | | 1976 | 6741 |
| the hypothalamo-pituitary-adrenocortical system. | | 1976 | 6744 |
| synaptic mechanisms in the substantia nigra. | | 1976 | 6745 |
| preliminary investigations of the metabolism and pharmacological activity of beta-hydroxytryptamines in mammals. | beta-hydroxytryptamine and beta-hydroxy-5-hydroxytryptamine were incubated with rat liver slices and oxidative deamination was established as the main route of metabolism: in both instances the corresponding indole-3-glycollic acids and indole-3-ethane diols were the major metabolites. however, the rates of deamination of beta-hydroxylated tryptamines, as measured manometrically, were found to be much slower than those of tryptamines nonhydroxylated in the side chain. the pharmacological activit ... | 1976 | 6751 |
| differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system. | in gallamine-immobilized cats, the caudate nucleus and the nucleus accumbens septi were perfused by means of a push-pull cannula and dopamine was measured in the perfusate. chlorpromazine (10 mg kg(-1)) and clozapine (20 mg kg(-1)), administered intravenously, enhanced the release of dopamine. the effect of chlorpromazine was similar in both regions whereas that of clozapine was more pronounced in the nucleus accumbens than in the caudate nucleus. furthermore, in the rat, sulpiride, clozapine an ... | 1976 | 6752 |
| the effect of cholinesterase inhibitors on the antimuscarinic effect of hemicholinium-3 (hc-3) in the rat. | the effect of hemicholinium-3 (hc-3) on responses of the rat isolated bladder and ileum to acetylcholine and carbachol was investigated in the absence and presence of a number of anticholinesterases. responses of the bladder to acetylcholine were potentiated by dfp, edrophonium, bw284c51 and physostigmine but were unaffected by the specific butyrylcholinesterase inhibitor iso-ompa. responses to carbachol were not potentiated by the anticholinesterases. hc-3 (1.7 x 10(-4) m) inhibited responses t ... | 1976 | 6755 |
| effect of blockade of 5-hydroxytryptamine re-uptake on drug-induced antinociception in the rat. | | 1976 | 6756 |
| influence of stomach emptying rate on tissue radioactivity after 14c imipramine in the rat. | | 1976 | 6759 |
| the effect of imipramine on isolated innervated guinea pig and rat urinary bladder preparations. | | 1976 | 6760 |
| interaction of beta-phenethylamine with dopamine and noradrenaline in the central nervous system of the rat. | | 1976 | 6762 |
| indwelling catheters for direct recording of arterial blood pressure and intravenous injection of drugs in the conscious rat. | | 1976 | 6764 |
| inhibition of rat synaptosomal catecholamine uptake by niflumic acid and indomethacin. | | 1976 | 6766 |
| effect of edetate disodium and reduced glutathione on absorption of acetazolamide from gi tract of rats. | the absorption of acetazolamide suspensions from in situ rat gastric and intestinal loop segments was studied. in 1 hr, 66.2 and 64.3% remained unabsorbed from the rat stomach and intestine, respectively. although 1% (w/v) reduced glutathione and 1% (w/v) (24 mm) edetate disodium had no effect on gastric absorption, drug absorption from the rat intestine (1 hr) was increased 1.5 and 2 times, respectively. it was hypothesized that the relatively poor intestinal absorption was due primarily to the ... | 1976 | 6773 |
| further studies on angiotensin tachyphylaxis. | rabbit aorta and rat fundus do not display tachyphylaxis to angiotensin ii (asp1)angiotensin ii) at 37 degrees c. these tissues do, however, display tachyphylaxis to sar1angiotensin ii (n-methylglycine 1 angiotensin ii) and dimethylglycine angiotensin ii, respectively, at this temperature. at 22 degrees c, both tissues displayed rapid tachyphylaxis to asp1angiotensin ii which was reversed on prolonged incubation in peptide-free medium. at 37 degrees c, but at a lower than normal ph (ph 6.5 inste ... | 1976 | 6785 |
| studies on adrenal phenylethanolamine n- methyltransferase (pnmt) with s k & f 64139, a selective inhibitor. | sk&f 64139 is a potent, reversible inhibitor of phenylethanolamine n-methyltransferase; its ic50 concentration in our standard assay system was 1 x 10(-7) m. kinetically, the compound is a competitive inhibitor with respect to norepinephrine but is uncompetitive when s-adenosylmethionine is the variable substrate. in contrast to a previously reported compound (sk&f 7698), the drug is only a weak alpha receptor antagonist (kb = 6 x 10(-6) m). in both the rat and squirrel monkey, sk&f 64139 produc ... | 1976 | 6786 |
| effect of fatty acids on the disposition of ammonia. | subcoma doses of fatty acids and ammonium salts injected intraperitoneally at the same time into rats or cats act synergistically to produce coma. under these circumstances, the blood ammonia, is more than double that when the nh4+ is given alone. after these observations a rat liver homogenate system was utilized to study the effect of fatty acids on ammonia utilization in urea, glutamate and glutamine synthesis in vitro. acetylglutamate-catalyzed urea synthesis was completely inhibited by 45 m ... | 1976 | 6789 |
| microsomal reductive glycosidase. | rat liver microsomes contain a phenobarbital inducible, nadph dependent, reductive glycosidase capable of cleaving several anthracycline antibiotics, including adriamycin and daunorubicin, to deoxyaglycone products. the ph optimum for the reaction ranges from 7 to 7.4, and no metal requirements are noted. molecular oxygen reversibly inhibits the microsomal enzyme greater than 95% at 20% oxygen partial pressure. carbon monoxide, skf 525a and sulfhydryl reagents are not inhibitory to the reaction, ... | 1976 | 6790 |
| neutral protease activity and erythropoietin production in the rat after cobalt administration. | the generation of erythropoietin purportedly involves the interaction of an enzyme, of renal origin, and a circulating plasma protein substrate. cobalt, which has the capacity to stimulate erythropoietin formation, was evaluated for its effects on renal and plasma protease activity; in addition, the nature of the erythrogenic mechanism was investigated. rats receiving one s.c. injection of cobalt demonstrated significant increases in activity of renal cathepsins a and b. the activity of a plasma ... | 1976 | 6791 |
| cholestyramine-induced inhibition of salicylazosulfapyridine (sulfasalazine) metabolism by rat intestinal microflora. | the effect of multiple oral administration of the hypocholesterolemic agent cholestyramine (a strongly basic anion-exchange resin) on the metabolism of salicylazosulfapyridine by microflora present in the colon and cecum was assessed in conventional rats by following the time course of salicylazosulfapyridine and its metabolites in the urine and feces. the intestinal metabolism of salicylazosulfapyridine (a single 100 mg/kg oral dose), which involves reduction of the azo linkage by bacterial azo ... | 1976 | 6792 |
| evaluation of the discriminative effects of morphine in the rat. | the discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete trial avoidance task. stimulus control of behavior was attained with a dose of morphine one-third to one-tenth of that used in previous studies. morphine produced dose-related discriminative effects over a 100-fold dose range. the stimulus control produced by the discriminative effects of morphine met the following criteria for classification as a specific narcotic effect: 1) oxymorphone, levor ... | 1976 | 6794 |
| pentamidine transport and sensitivity in brucei-group trypanosomes. | sensitivity to pentamidine of bloodstream forms and culture forms of trypanosoma brucei brucei, strains of this subspecies, and strains of t. brucei rhodesiense characteristically differs in vitro. analyses of transport parameters for pentamidine uptake in these organisms show differences that correspond with drug sensitivity. long slender bloodstream forms of t. b. brucei have a high affinity for the drug and high rates of uptake at indicated by km and vmax values for 3hpentamidine transport. a ... | 1976 | 6797 |
| hemodynamics of experimentally hypertensive rats in conscious and anesthetized states. | cardiac output was measured by a pulse contour method in reno-vascular hypertensive rats, deoxycorticosterone (doc) hypertensive rats and normotensive control wistar rats in the conscious state. all rats were male in sex and 12-13 weeks of age (2-3 weeks after operation in the hypertensive rats). cardiac output per body weight was not significantly different among the groups. therefore, the hypertension in the experimentally hypertensive rats in the conscious state was ascribable to an increased ... | 1976 | 6808 |
| radioreceptor assay of prolactin. | the authors prepared the prolactin marker with iodine-125 and made iodine-125-human prolactin and iodine-125-sheep prolactin. to make the complex, iodine-125-human prolactin was incubated with prolactin receptors isolated from female rat liver cell membranes. this complex is reversible and can be replaced by cold human prolactin. studies with mammary glands of various animals have indicated that the prolactin receptor seemed to be a peptide or a protein of macromolecules in chemical nature. ... | 1976 | 6810 |
| effect of taurine on alteration in adrenal functions induced by stress. | when rats were exposed to immobilized cold stress, adrenaline content in the adrenal gland as well as noradrenaline content in the brain stem were reduced drastically, while noradrenaline content in the atria was not altered by the application of stress. oral administrations of taurine (4-7 g/kg/day, for 3 days) prevented the stress-induced decline of adrenaline in the adrenal gland and this preventive effect could not be duplicated by the administration of l-isoleucine or dl-methionine. in hypo ... | 1975 | 6814 |
| prolonged moderate hypothermia and experimental endotoxin shock. | | 1976 | 6824 |
| the effect of chitin powder on the healing of skin wounds. | locally administered chitin powder has influences favourably the healing of the circular, open skin wounds on the dorsum. the tensil strength of the 7 days' incised skin wounds on the dorsum has increased under the effect of chitin powder suspension administered 3 days before the incision. the total hydroxyproline content was not influenced significantly by the chitin powder either in the case of circular open skin wounds or of incised dorsal skin wounds. | 1976 | 6829 |
| differential effects of neuroleptic and other psychotropic agents on acquisition of avoidance in rats. | | 1976 | 6855 |
| adenylate cyclase and gastric acid secretion. | | 1976 | 6866 |
| selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase in sympathetic ganglia in organ culture: role of glucocorticoids as modulators. | | 1976 | 6895 |
| serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors. | | 1976 | 6896 |
| induction of tyrosine 3-monooxygenase elicited by carbamylcholine in intact and denervated adrenal medulla: role of protein kinase activation and translocation. | | 1976 | 6897 |
| electron spin resonance study of 17o-enriched oxybenzoapyrene radical. | | 1976 | 6898 |
| trans-synaptic regulation of ribonucleic acid biosynthesis in rat adrenal medulla. | | 1976 | 6899 |
| enzyme activities of jejunal mucosa in experimental blind loop syndrome of rat. | | 1976 | 6913 |
| methanol poisoning in the folate-deficient rat. | | 1976 | 6915 |
| different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents. | the influence of clonidine on alpha-adrenoreceptors in the central nervous system of rats and mice has been investigated. both functional events due to postsynaptic receptor stimulation (flexor reflex activity, motor activity) and biochemical changes have been considered. 1. clonidine was less potent in stimulating the hindlimb flexor reflex activity of spinal rats than in inhibiting the alpha-methyltyrosine-induced disappearance of noradrenaline in the spinal cord and in the whole brain of rats ... | 1976 | 6918 |
| noradrenaline synthesis and utilization: control by nerve impulse flow under normal conditions and after treatment with alpha-adrenoreceptor blocking agents. | the changes in the synthesis and utilization or noradrenaline cranial and caudal to an acute section of the rat spinal cord have been used to investigate the importance of nerve impulses for these processes. 1. cranial to a lesion of the spinal cord, the alpha-methyltyrosine-induced disappearance of noradrenaline was accelerated by the alpha-adrenoreceptor blocking agents yohimbine (10 mg/kg), piperoxan (60 mg/kg) and tolazoline (50 mg/kg). in the absence of nerve impulses caudal to a lesion of ... | 1976 | 6919 |
| studies of rat pineal gland guanylate cyclase. | | 1976 | 6922 |
| beta adrenergic-blockers decrease adrenergically stimulated n-acetyltransferase activity in pineal glands in organ culture. | | 1976 | 6923 |
| the effect of acth and several antimetabolites of vitamin b6 on the activity of tyrosine aminotransferase in the liver of intact and hypophysectomized rats. | acth injected intraperitoneally in a dose of 140 units per 1 kg of body weight to intact rats or to rats subjected to hypophysectomy 24 hours before the experiment produced an increase in the activity of tyrosine-aminotrasferase in the liver (4.5 or 2.5 times, respectively) in comparison with the normal. d-cycloserine and its dimere injected intraperitoneally to the intact starving rats in a dose of 2.0-2.5 g per 1 kg of body weight produced in 4 hours a sharp elevation in the liver of the activ ... | 1975 | 6954 |
| beta-adrenergic blockade reduces the severity of acute renal failure in rats. | propranolol administration in the hypoxic model of acute renal failure (arf) in rats has reduced plasma renin activity (pra) and uraemia as compared to untreated controls. p113 has no effect on uraemia but increased pra in arf. a combination of both drugs is no more effective in reducing uraemia than propranolol alone. these results support the view that beta-adrenergic blockade by propranolol reduces the severity of arf by preventing the post-hypoxic release of renin. | 1976 | 6958 |
| the inhibition by adp of nadph-supported adrenal steroid 11beta-hydroxylation. | the 11beta-hydroxylation of deoxycorticosterone to form corticosterone in adrenal mitochondria has been found to be inhibited by adp and atp, with adp being the more inhibitory of the two. the evidence suggests that the adp directly affects the enzyme system. | 1976 | 6972 |
| the startle response in rats: effect of ethanol. | the effects of acute and chronic ethanol intake on the startle response was examined in male rats. ethanol given ip produced a dose-dependent decrease in the amplitude of the startle response measured 30 min later. with a dose of 1 g/kg, the effect was evident at 15 min and had recovered substantially by 60 min. the effect of ethanol on the startle response was potentiated by pretreatment of the animals with pimozide, haloperidol, and p-chlorophenylalanine but not by propranolol, phenoxybenzamin ... | 1976 | 6973 |
| plasma angiotensin ii levels and water intake following beta-adrenergic stimulation, hypovolemia, cellular dehydration and water deprivation. | a comparison of the effects of extracellular and intracellular thirst stimuli on plasma levels of angiotensin ii was made in rats. the administration of polyethylene glycol and isoproterenol elicited a strong drinking response and resulted in a significant increase in plasma angiotensin ii. there was a significant correlation between the volume of water intake and plasma angiotensin ii levels following the injection of polyethylene glycol but not following isoproterenol. drinking was also elicit ... | 1976 | 6974 |
| selective depleting effect of syrosingopine on brain catecholamine levels with relation to morphine analgesia in the rat. | reserpine was the most potent, rescinnamine the next and syrosingopine the weakest in the depleting effects on brain amines of rauwolfia alkaloids. after syrosingopine, brain dopamine (da) was decreased to a smaller degree and with a shorter duration as compared with norepinephrine (ne) and serotonin (5-ht), whereas reserpine elicited a marked and long lasting reduction in these amines. accordingly, syrosingopine induced a depletion of brain ne and 5-ht without alteration in brain da content 2-4 ... | 1976 | 6976 |
| problems in identification of the beta-adrenergic receptor. | | 1976 | 6980 |
| mechanisms and regulation of biosynthesis of saturated fatty acids. | | 1976 | 6981 |
| possible actions of opiates upon synapses. | | 1976 | 6994 |
| prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. | reserpine (1 mg/kg) was administered to pregnant rats on days 12, 13 and 14 of gestation. although adrenal tyrosine hydroxylase and dopamine beta-hydroxylase activities were normal in the offspring at 4 days of postnatal age, both were elevated by 17 days and the elevations persisted into adulthood. the changes may result from permanently increased sympatho-adrenal stimulation. | 1975 | 7001 |
| the effect of butaclamol and of other neuroleptic agents on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. | the effects of the two enantiomers of butaclamol and of several neuroleptics on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity was investigated. the (+) but not the (-) enantiomer of butaclamol reverses the apomorphine-elicited enzyme inhibition. (+) butaclamol is more potent than the other tested neuroleptics. all the tested neuroleptics reverse the apomorphine-elicited enzyme inhibition but their relative potency differs. using two criteria, namely the concen ... | 1975 | 7003 |
| subsynaptosomal distribution, inhibition, and characterization of the binding of (14c) 5-oh-indole-3-acetaldehyde to brain preparations. | the distribution of the monoamine oxidase (mao) dependent binding of 14c serotonin as well as of pre-formed 14c 5-oh-indole-3-acetaldehyde to synaptic subfractions paralleled the gross distribution of mao. the binding of 14c serotonin and mao activity in brain preparations was inhibited by cns antidepressants (imipramine) or stimulants (caffeine), by hallucinogens (n,n-dimethyltryptamine), sedatives (chlorpromazine), and other drugs. the protein-lipid nature of the binding macromolecule was dete ... | 1976 | 7005 |
| changes in skeletal muscle cell ph during graded changes in pco2. | blood perfusing isolated dog gracilis muscles was equilibrated with co2 tensions ranging from 30 to 120 mm hg, resulting in venous p co2 from 35 to 135 mm hg. extracellular ph values ranged from 6.96 to 7.41, and muscle cell ph, calculated from dmo distribution, ranged from 6.64 to 6.94. when intracellular ph was plotted as a function of the corresponding extracellular ph, a linear relationship (r = 0.92) was observed throughout the entire ph range. the slope deltaphi/deltaphe was 0.64, without ... | 1976 | 7009 |
| cholinergic changes during conditioned suppression in rats. | levels of acetylcholine were significantly elevated in the telencephalon and diencephalon + mesencephalon of rats killed by near-freezing during conditioned suppression of food-reinforced lever pressing, whereas levels of serotonin, dopamine, and norepinephrine were not altered. these neurochemical changes were not seen in rats serving as controls for conditioning experience, activity levels, or stimulus presentation. | 1976 | 7016 |
| plasmatic arterionecrosis and its thrombotic occlusion. | | 1976 | 7030 |
| the genetic basis for responses to major transplantation antigens. | | 1976 | 7037 |
| effect of atropine sulfate, papaverin hc1 and antihistaminic preparations on isolated organs of various experimental animals. | | 1975 | 7039 |
| species and phenobarbitone-induced differences in the kinetic constants of liver microsomal harmine o-demethylation. | 1. the apparent kinetic constants for the o-demethylation of harmine to harmol by 10 000 g supernatant fractions from livers of mice, rats, guinea-pigs, rabbits, cats and cows have been determined. the km values were 10-39 mum and vmax 0-25 and 1-65 nmol/mg protein/min. 2. optimal conditions of incubation time and nadp requirements differed between species. in all species except cat and cow the rate of o-demethylation of harmine was linear for 5 min, but in the latter species was linear for 15 m ... | 1976 | 7043 |
| content of neuroactive amino acids in the hypothalamus and liver of rats in experimental stomach ulcer and their changes under the effect of cholinolytic drugs. | | 1975 | 7089 |
| rats and bilharziasis in guadeloupe. | the rats in guadeloupe (rattus rattus and rattus norvegicus) may play a part in schistosomiasis in three ways: - by harbouring fertile s. mansoni, a fact which serves to increase the total population of the parasite and may eventually take part in the infestation of man; - by harbouring a great number of ribeiroia marini, a trematode whose larval stages sterilize biomphalaria glabrata, the vector of schistosomiasis; - simply by eating b. glabrata. the quantitative influence of these contradicto ... | 1975 | 7114 |
| a new nematode (allantonematidae) parasite of heliophilus (t diptera, syrphidae). | for the second time, the authors have found a new entomophagous nematode parasitic in syrphidae. the first species, which was described as syrphonematidae nov. fam., is living in the duct of various aphidophagous species of syrphidae. this one has been found in the hemocoel of adults of helophilus trivittatus fabricius and h. pendulus linneaus (eristalinae with aquatic rat tailed larvae). it seems to belong to the genus iotonchium (allantonematidae), which was known as yet only by the free-livin ... | 1975 | 7118 |
| presence of angiostrongylus cantonensis at la réunion. | the eosinophilic meningitis due to angiostrongylus cantonensis is well known on madagascar and on mauritius island, but was never described on reunion island. two cases have been lately oberved in doctor jay's department at gabriel martin's hospital. local achatines were dissected and contained larvae which, when absorbed by rats, were found in there brains ten days later. these larvae belong certainly to angiostrongylus genus, but the species has not yet been found with certitude. lately infest ... | 1975 | 7126 |
| search for persistent epizootic venezuelan encephalitis virus in guatemala, el salvador and nicaragua during 1970-1975. | evidence was sought during 1970-1975 of persistence of equine-virulent venezuelan encephalitis (ve) virus in regions of central america that were heavily involved in the epidemic-equine epizootic of 1969. (a) four sentinel horses were exposed in an arid, upland region of the atlantic drainage of guatemala during august-october 1970, but no horse became infected. (b) the epicenter region of the 1969 outbreak, in southwestern guatemala and southwestern el salvador, was studied during july 1970-feb ... | 1976 | 7139 |
| a decrease in cell-mediated immunity in uremia associated with an increase in activity of suppressor cells. | the graft-versus-host (gvh) reactivity of uremic and control spleen cells was studied by popliteal lymph node assay in the rat. the reaction evoked by cells from animals with severe uremia was conspicuously weaker than that evoked by control cells. the magnitude of the gvh reaction induced by control cells was directly proportional to dose, while with the uremic cells the same increases in dose led only to insignificant increases in the strength of the gvh reaction. when mixtures of syngeneic co ... | 1976 | 7140 |
| effects of hypoxia and freon 12 on mechanics of cardiac contraction. | data are presented which indicate that the mechanism of tension depression and subsequent recovery from dichlorodifluoromethane (freon 12), an aerosol gas recently described as a potent cardiac depressant agent, differs from that of hypoxia. to analyze these differences, 22 rat papillary muscles, contracting isometrically in a myograph, were studied during and subsequent to 15-min interventions of of hypoxia. freon 12 with adequate oxygenation, or freon 12 combined with hypoxia. during each of t ... | 1976 | 7144 |
| reduced high-energy phosphate levels in rat hearts. i. effects of alloxan diabetes. | significant alterations in heart carbohydrate and lipid metabolism are present 48 h after intravenous injection of alloxan (60 mg/kg) in rats. it has been suggested that uncoupling of oxidative phosphorylation occurs in the alloxanized rat heart in vivo, whereas normal oxidative metabolism has been demonstrated in alloxan-diabetic rat hearts perfused in vitro under conditions of adequate oxygen delivery. we examined the hypothesis that high-energy phosphate metabolism might be adversely affected ... | 1976 | 7145 |
| variations in the activity of various curarizing substances as a function of the time of administration. | this experiment was carried out upon the male-adulte-af spf-wister rat, anesthetized by the use of pentobarbital-na at the only dosage of 40 mg/kg/ip and put under artificial ventilation. the animals were divided into two groups: group i, "diurnal animals" curarized between 10 a.m and 4 p.m; group 2, "nocturnal animals" curarized between 9 and 12 p.m. four drugs of the curarimimetic (pachycurare, non-depolarizing) type: gallamine, d-tubocurarine, pancuronium and ah-8165 were studied at doses pre ... | 1975 | 7164 |
| central noradrenergic control of blood pressure. | | 1976 | 7183 |
| behavioral pharmacology and toxicology. | | 1976 | 7185 |
| toxicology of inhalation anesthetics and metabolites. | | 1976 | 7186 |
| mechanism of action of miconazole: labilization of rat liver lysosomes in vitro by miconazole. | miconazole, a potent antifungal agent, labilizes rat liver lysosomes. its labilizing effect is followed by measuring the release of lysosomal hydrolases, namely, acid phosphatase, beta-glucuronidase, and arylsulfatase a. the effect of miconazole is concentration dependent in the range of 10(-5) to 1.2 x 10(-4) m. however, at higher concentrations, miconazole inhibits enzyme release but does not inhibit enzyme activities per se. the effect of miconazole depends on the drug/lysosome ratio and is i ... | 1976 | 7188 |
| solubilization and partial purification of steroid sulfatase from rat liver: characterization of estrone sulfatase. | | 1976 | 7200 |
| the binding of penicillin antibiotics to a human liver protein. | | 1976 | 7205 |
| phosphatidylinositol exchange protein. effects of membrane structure on activity and evidence for a ping-pong mechanism. | | 1976 | 7210 |
| effect of various detergents on kinetic characteristics of lipid peroxidation systems in rat liver microsomes. | | 1976 | 7212 |
| cell populations in a renal lesion produced by local injection of xenogeneic spleen cells in cyclophosphamide-treated rats. | the frequency and distribution of donor and host lymphoid cells in different stages of a lesion produced by injecting mouse spleen cells beneath the renal capsules of rats treated 24 h previously with cyclophosphamide have been studied by immunofluorescent staining with species-specific anti-lymphocyte sera. donor cells were predominant in the early stages of the reaction and penetrated the outer part of the renal cortex, but by day 7 when the lesion reached its maximum extent most of the infilt ... | 1975 | 7220 |
| facilitation of the growth of an allogeneic tumour by suppressor cells in newborn rats. | the intravenous injection of as few as 15 walker tumour cells into newborn rats consistently resulted in the development of pulmonary metastases and the death of the recipient within 2 weeks. neither the outcome of tumour cell injection nor the interval until death could be modified by transferring 2 x 10(7) lymphocytes from tumour-immune adult rats to the neonataal hosts. in contrast with this failure to transfer adoptive anti-tumour immune responses to intact recipients, the administration of ... | 1976 | 7221 |
| suppressor cells in homograft tolerant rats. | if sufficient normal syngeneic lymphocytes to effect skin graft rejection are transferred to homograft tolerant rats, a prolonged period elapses before lymphoid cells from the recipient acquire normal levels of gvh responsiveness against tissues of which the donor was previously tolerant (silvers and billingham, 1970; elkins, 1972; miyamoto and mccullagh, 1974). although the ability of lymphoid populations of such animals to mount gvh reactions can be demonstrated to reside in donor type cells d ... | 1976 | 7222 |
| interactions of some acceptors with superoxide anion radicals formed by the nadph-specific flavoprotein in rat liver microsomal fractions. | in rat liver microsomal fractions oxidation of adrenaline was effected by superoxide anion radicals (o2-), whereas cytochrome c, 2,6-dichlorophenol-indophenol and ferricyanide accepted electrons from nadph-specific flavoprotein only directly. nitro blue tetrazolium was reduced both by o2- and by the direct acceptance of electrons. elevation of ph and addition of menadione shift the nitro blue tetrazolium reduction towards the o2--dependent pathway. from the values of the kinetic constants for in ... | 1976 | 7236 |
| evidence for the involvement of cytochrome p-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes. | | 1976 | 7252 |
| cytochrome p450 as an oxene transferase. | | 1976 | 7255 |
| inactivation of phosphoenolpyruvate carboxykinase by acetaldehyde. | | 1976 | 7256 |
| regulation of adrenal tyrosine hydroxylase activity: neuronal versus local control studied with apomorphine. | | 1976 | 7260 |