| the effects of a hydroxyl group on some chemical and biological properties of n-pentyl ammonium salts. | the effects of a hydroxyl group on the activity and affinity of compounds related to n-pentyltrimethylammonoum have been studied on the guinea-pig ileum, frog rectus, acetylcholinesterase and on partitioning (rm) and size (phiov, vm). the hydroxyl group lowered affinity in all tests, confirming the importance of hydrophobic forces in binding to receptors. activity on the ileum was lowered appreciably but on the rectus only slightly. the effects on rm did not indicate any interactions between hyd ... | 1978 | 31434 |
| the influence of neuroleptics on amphetamine metabolism in the rat and guinea-pig. | | 1978 | 31438 |
| a possible augmentation of the extraneuronal adrenaline uptake caused by inhibition of the neuronal component. | | 1978 | 31439 |
| adrenergic and 'non-adrenergic' components in the contractile response of the vas deferens to a single indirect stimulus. | 1. the mechanical response of the longitudinal smooth muscle of the rat vas deferens to stimulation of its motor nerves by a single pulse has been examined. the motor nerves were stimulated in vivo via the spinal outflows in the pithed rat or in vitro by field stimulation. 2. the contraction in the whole vas consisted of two components, an initial, rapid, brief contraction reaching a maximum at 300 msec and a second, slower and more prolonged contraction reaching its maximum at 600 msec. when th ... | 1978 | 31466 |
| 2-methoxyphenylethanolamines, potential beta-adrenergic blocking agents. | the effect of the introduction of a 2-methoxy substituent on the beta-adrenergic antagonistic properties of a series of 3- and 4-substituted phenylethanolamines (1) was studied. both the series of bromo- and methyl-substituted compounds behaved similarly, indicating that electronic forces are not significant in determining beta-adrenergic antagonist activity. when compared with the corresponding phenylethanolamines without a 2-methoxy substitutent, the 2-methoxy-4-substituted derivatives (3a and ... | 1978 | 31474 |
| molecular properties of the adrenergic alpha receptor. 2. optimum covalent inhibition by two different prototypes of polyamine disulfides. | | 1978 | 31477 |
| nondepressant beta-adrenergic blocking agents. 1. substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols. | a series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for beta-adrenergic blocking activity and direct myocardial depressant action. the cis- and trans-diols 12--15 were found to retain the beta-blocking potency of propranolol but to lack its myocardial depressant action. compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent. | 1978 | 31485 |
| on the effect of some important groups of drugs on peristaltic activity in isolated frog stomach. | | 1978 | 31519 |
| [recent neurochemical data on hepatic encephalopathy]. | | 1978 | 31522 |
| slow synaptic excitation mediated by serotonin in auerbach's plexus. | | 1978 | 31569 |
| the site of action of capsaicin on the guinea-pig isolated ileum. | | 1978 | 31571 |
| synthesis of some alkoxybenzamide derivatives as smooth muscle relaxant agents. | the preparation of 16 new n-substituted p-aminobenzamide derivatives which contain diethylaminoethyl-n-methylpiperazine, piperidine and morpholine moieties were described. preliminary pharmacological testing of representative compounds showed that some of the prepared compounds possess anticholinergic and antihistaminic activities. | 1978 | 31627 |
| [the potentiating effect of a new alpha-adrenergic blocking agent (e-643) on the action of bronchodilators (author's transl)]. | | 1978 | 31666 |
| toxicities of sea anemone (anemonia sulcata) polypeptides in mammals. | | 1978 | 31713 |
| [transplantation immunology and pregnancy]. | | 1978 | 31742 |
| a new chromogenic substrate for gamma-glutamyl transpeptidase. | | 1978 | 31816 |
| deodorization of pig feces by actinomycetes. | peg feces, a malodorous substance causing environmental pollution, were completely deodorized within 2 days by streptomyces. the optimum conditions for deodorization were as follows: ph, 8.6 to 10; temperature, 35 to 40 degrees c; moisture content, 42 to 63%; and minimum amount of inoculum, 2 g of seed culture per 10 g of fresh feces. many kinds of microorganisms were isolated from the deodorized feces, of which only actinomycetes were found to have the ability to deodorize. two strains with str ... | 1978 | 31838 |
| [hyperglycemic effect and glycogenolytic action of catecholamines]. | | 1978 | 31843 |
| active site in zymogens. proton magnetic resonance ph titration curves of histidine-57 in porcine and bovine trypsinogens and in their complexes with bovine pancreatic trypsin inhibitor (kunitz). | | 1978 | 31899 |
| characterization of glutathione reductase from porcine erythrocytes. | glutathione reductase (nad(p)h: oxidized-glutathione oxidoreductase, ec 1.6.4.2) was purified to homogeneity from porcine erythrocytes by use of affinity chromatography on 2',5'-adp-sepharose 4-b. analytical ultracentrifugation experiments were analysed to give the following physical parameters for the enzyme: s20,w = 5.7 s, d20,w = 50 microgram2/s, and mw = 103 000 (protein concentration, 0.5 mg/ml). the frictional ratio was 1.37 and the stokes radius was 4.3 nm. the enzyme molecule is a dimer ... | 1978 | 31912 |
| spectrophotometric titration of phenolic groups of pepsin. | the ionization of tyrosine residues in diazotized pepsin under various solvent conditions was studied. all tyrosyl residues of the protein titrated normally with a pk of 10.02 in 6 m guanidine hydrochloride solution. on the other hand, two stages in the phenolic group titration curve were observed for the inactivated protein in the absence of guanidine hydrochloride; only about 10 tyrosine residues ionized reversibly up to ph 11, above which titration was irreversible. the irreversible titration ... | 1978 | 31919 |
| factors influencing the release of acetylcholine from the myenteric plexus of the ileum of the guinea-pig and rabbit. | 1 the effects of electrical stimulation, changes in external ion concentrations and various drugs on acetylcholine release from the myenteric plexus were measured by bioassay in the presence of physostigmine and by recording the responses of the longitudinal muscle. in preparations from the guinea-pig, the acetylcholine output per pulse increased with decreasing frequency of stimulation and reached its maximum at a frequency of 0.017 hz (1/min) and thus ensured that the output per unit of time w ... | 1978 | 31960 |
| a phenoxypropanolamine derivative (ro363) with selective beta1-receptor stimulant actions. | | 1978 | 32049 |
| irreversible beta-adrenoceptor blockade of atrial rate and tension responses. | the competitive reversible beta-adrenoceptor antagonist activity of ro 03-5255 [1-(5-acetylaminobenzfuran-2-yl)-2-isopropylaminoethanol] upon isoprenaline-induced increases of the rate and tension of guinea-pig isolated atria is described. the chlorinated derivative [ro 03-7894; 1-[5-chloracetylaminobenzfuran-2-yl)-2-isopropyl-aminoethanol] in contrast exhibited concentration-dependent non-competitive irreversible blocking activity as measured by depression of the maximum responses which were no ... | 1978 | 32050 |
| blockade by wb 4101 of alpha-adrenoceptors in the rat vas deferens and guinea-pig taenia caeci. | the effectiveness of wb 4101, a recently described alpha-adrenoceptor antagonist, in blocking an excitatory and two inhibitory responses to alpha-receptor activation was studied. one of the inhibitory responses was the reduction by the selective alpha-agonist amidephrine of carbachol contractures of isolated guinea-pig taenia caeci. wb 4101 antagonised this inhibition with a schild plot slope of 0.99 and a pa2 of 8.9. the same pa2 value was obtained for blockade of the contractile effect of amid ... | 1978 | 32052 |
| antagonism of central histamine h1 receptors by antipsychotic drugs. | the activity of 8 widely antipsychotic drugs as antagonists of central histamine h1 receptors was determined from the inhibition of the binding of 3h-mepyramine to a membrane fraction from guinea-pig brain. the phenothiazines examined, clorpromazine, fluphenazine, thioridazine and trifluoperazine, were all potent h1 antagonists. both alpha- and beta-flupenthixol were potent inhibitors, but butaclamol, although less potent, showed stereospecificity. haloperidol and spiperone were markedly weaker ... | 1978 | 32056 |
| ganglion and cholinergic blocking activities of some synthetic quaternised quinoline derivatives. | | 1978 | 32134 |
| in vitro cultivation of leprosy bacilli in hyaluronic acid-based medium. 2. progress and developing concept of the role of hyaluronic acid suggested by culture and armadillo infection studies. | progress is summarized relating to the verification, identification of m. leprae and understanding of the process of adaptation the pathogen passes through before in vitro growth takes place. it is recognized that hyaluronic acid apparently does not serve as a source of energy but the possibility is presented that it plays a role in the reconstruction of m. leprae cell walls made "leaky" by constant intracellular life. this apparently occurs, in culture, initially by the development of coccoid f ... | 1978 | 32143 |
| crystalline reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase from pig adrenocortical mitochondria. essential histidyl and cysteinyl residues of the nadph-binding site and environment of the adrenodoxin-binding site. | pig nadph-adrenodoxin reductase was crystallized from pig adrenocortical mitochondria and its physicochemical properties were investigated. pig nadph-adrenodoxin reductase is a typical flavoprotein. its optical absorption spectrum showed peaks at 272, 377, and 450 nm in the oxidized form. the adrenodoxin reductase contained one fad per mol. the molecular weight was 49,000. the isoelectric points of the adrenodoxin reductase and its complex with adrenodoxin were 5.3 and 4.6, respectively. pig nad ... | 1978 | 32168 |
| concentrations of hydrogen ions, oxygen, carbon dioxide and bicarbonate in porcine follicular fluid. | | 1978 | 32217 |
| the effect of pge1 on peristalsis and on perivascular nerve inhibition of peristaltic activity in guinea-pig isolated ileum. | the effect of pge1 on peristalsis of guinea-pig isolated ileum was examined using a modified trendelenburg method to evoke and record peristaltic activity. pge1 (14 nm, 0.11 microm and 0.56 microm) increased peristaltic activity of both longitudinal and circular muscle, mainly by increasing the amplitude of contraction. preparations of ileum subjected to a 'minimal' peristaltic stimulus were more sensitive to the effects of pge1 than were preparations subjected to a 'just-maximal' peristaltic st ... | 1978 | 32240 |
| effects of the antiemetic drug domperidone on guinea-pig isolated gastrointestinal tissue [proceedings]. | | 1978 | 32289 |
| uptake of amphetamine by guinea-pig lung in vitro [proceedings]. | | 1978 | 32312 |
| effects of 5-hydroxykynurenamine, a metabolite of 5-hydroxytryptamine, on guinea-pig isolated trachea. | | 1979 | 32367 |
| evidence for the existence of another type of histamine h2-receptor in guinea-pig ileum. | | 1979 | 32369 |
| metoclopramide reverses inhibitions of electrically-induced contractions of guinea-pig isolated ileum by anti-inflammatory drugs. | | 1979 | 32372 |
| ca2+-dependent tension generation in chemically 'skinned' cardiac trabeculae: effect of ph [proceedings]. | | 1978 | 32392 |
| [pharmaco-kinetic aspects of protein-binding (author's transl)]. | binding of drugs to plasma proteins will influence distribution and elimination especially if factors interfere altering the extent of binding. these factors are: dependence on species, age, h+-concentration, speed of i.v. injection or the interaction of another drug for instance. considering the quantitative aspects changes in binding to the plasma proteins will turn only then relevant to drug action if the extent of alteration is very large or the drugs are bound to a very high degree. but the ... | 1978 | 32427 |
| the isolation of carbon dioxide-requiring (carboxyphillic) type 19 pneumococcus (streptococcus pneumoniae) from diseased guinea-pigs. | type 19 pneumococcus was isolated only in anaerobic cultures from tissue fluids of guinea-pigs suffering from exudative pericarditis and pleuropneumonia. the organism was pathogenic to mice even after 40 subcultures. further study showed it to be carboxyphilic rather than anaerobic. the necessity of specifying various atmospheric conditions in the diagnostic bacteriological isolation routine is emphasized. | 1978 | 32435 |
| the effect of temperature on mixed function amine oxidase intrinsic fluorescence and oxidative activity. | | 1978 | 32477 |
| pharmacological characterization of histamine receptors mediating the stimulation of cyclic amp accumulation in slices from guinea-pig hippocampus. | | 1978 | 32479 |
| tyrosine hydroxylase and dopa decarboxylase activities in the guinea-pig uterus: further evidence for functional adrenergic denervation in association with pregnancy. | | 1979 | 32500 |
| growth and cell replacement in the new-born pig intestine. | | 1978 | 32546 |
| fertilization: a uterine glycosaminoglycan stimulates the conversion of sperm proacrosin to acrosin. | acrosin is a proteinase required for mammalian fertilization, and in freshly ejaculated spermatozoa exists as an inactive zymogen, proacrosin. a factor prsent in uterine flushings of gilts stimulates the conversion of highly pruified boar proacrosin to acrosin. characterization of this factor indicates that its active component is a glycosaminoglycan. | 1979 | 32621 |
| gonadotrophic hormones and testicular descent. | the effect of fetal decapitation on gubernacular development and testicular descent was studied in the pig. gubernacular development was unaffected and testicular descent occurred normally in decapitated fetuses. neither testicular descent nor gubernacular development could be induced by hcg or lh-rh, administered to naturally unilateral cryptorchid prepuberal pigs in doses comparable to those used in human therapy. gubernacular development and, subsequently, testicular descent seem to be indepe ... | 1978 | 32850 |
| differentiation of the roles of histamine h1- and h2-receptors in the mediation of the effects of histamine in the isolated working heart of the guinea-pig. | 1 differentiation of the roles of histamine h1- and h2-receptors in the mediation of the effects of histamine on the isolated working heart of the guinea-pig was achieved through the use of histamine and selective histamine receptor agonists and antagonists. 2 histamine over the dose range 10(-9) mol to 10(-6) mol produced dose-related increases in sinus rate, left intraventricular pressure (lvp)max, lvdp/dtmax, coronary flow, aortic flow, total cardiac output and external pressure-volume work. ... | 1979 | 32943 |
| lack of release of prostaglandins from isolated perfused lungs during pulmonary hypertension and oedema. | 1 the effects on pulmonary prostaglandin synthesis of pulmonary hypertension and oedema have been studied. 2 seventeen isolated lungs of rabbit, cat and guinea-pig were perfused with plasma, whole blood or krebs ringer solution in a recirculating system. 3 the venous effluent from the lungs superfused (10 ml/min) a series of smooth muscle tissues sensitive to prostaglandins and thromboxane a2; these were: rat stomach strip, rat colon, chick rectum and rabbit aorta. 4 left atrial pressure was inc ... | 1979 | 32945 |
| the sites of action of 5-hydroxytryptamine in nerve-muscle preparations from the guinea-pig small intestine and colon. | 1 the sites of action of 5-hydroxytryptamine (5-ht) were examined in isolated segments of guinea-pig intestine. mechanical records were taken from the longitudinal muscle of the ileum and proximal colon and from the circular muscle of the ileum and distal colon.2 in order to examine direct actions of 5-ht, nerve-mediated responses were blocked with tetrodotoxin (0.2 mug/ml). there was a gradient in the responsiveness of the longitudinal muscle of the ileum; in the proximal ileum it was usually u ... | 1979 | 32947 |
| species differences in catecholamine uptake and storage, cyclic amp levels and adenyl cyclase activity in heart muscle. | | 1978 | 33007 |
| a radiometric method for the measurement of l-asparagine synthetase activity: comparison with available methods. | | 1978 | 33075 |
| evidence for multiple electronic forms of two-electron-reduced lipoamide dehydrogenase from escherichia coli. | results are presented which demonstrate that the 2-electron-reduced lipoamide dehydrogenase (ec 1.6.4.3) from escherichia coli is a mixture of species. in catalysis, this enzyme cycles between the oxidized and the 2-electron-reduced forms. three spectrally distinct species are indicated in the ph range 5.8 to 8.0 from measurements of the fluorescence and visible spectra during dithionite titration. these have the following properties. 1) a fluorescent form where the fad is oxidized and the activ ... | 1979 | 33177 |
| a comparison by 220-mhz nmr of histidine hydronium ion titrations in porcine pancreatic ribonuclease and an extensively deglycosylated derivative. | 220-mhz nmr was used to observe the titration behavior of the 5 histidine residues in porcine pancreatic ribonuclease (ribonucleate pyrimidine-nucleotido-2'-transferase (cyclizing), ec 3.1.4.22) and a derivative prepared by removal of 80% of the attached carbohydrate from this glycoprotein. resonances due to histidine c-2 protons were observed over the full ph range for 3 of the residues; such resonances for the remaining 2 histidine residues broadened out as the ph was increased. resonances due ... | 1979 | 33180 |
| structural studies of fc receptors. i. binding properties, solubilization, and partial characterization of fc receptors of macrophages. | | 1979 | 33218 |
| the use of a colour reagent for the detection and estimation of benzodiazepines and their benzophenone derivatives. | | 1978 | 33228 |
| possible differences in alpha-adrenoceptors in rat, guinea-pig and rabbit spleen. | | 1979 | 33240 |
| morphology and molecular composition of isolated postsynaptic junctional structures. | the solubilization of isolated brain synaptosomal plasma membranes by various detergents was studied and in each case found to depend upon detergent concentration. by using conditions sufficient to extract maximally protein and phospholipid from the membranes, postsynaptic junctional particles were isolated with each of four detergents and their ultrastructural appearances and protein contents compared. two basic structural forms were identified. one, isolated with triton x-100, consists of a pl ... | 1978 | 33388 |
| the destruction of pig helminth ova and larvae in a slurry treatment process. | it was established that a thermophilic system for the treatment of pig slurry at 55 degrees c rapidly killed the free living stages of three common pig parasites. this treatment could be beneficially incorporated in any pig slurry recycling process, whether to land or to animals. | 1978 | 33482 |
| proceedings of paediatric societies. north american society for pediatric gastroenterology and european society for paediatric gastroenterology and nutrition, joint meeting, paris, france may 4-6 1978. | | 1978 | 33525 |
| nervous control of pancreatic exocrine secretion in pigs. | the pancreatic secretion of fluid, bicarbonate and protein in response to electrical stimulation of the vagus and splanchnic nerves, to exogenous and endogenous secretin and to various pharmacological agents was studied in anesthetized young pigs (21 kg). vagal stimulation increased flow, bicarbonate output and protein output in a frequency dependent manner; the half maximal effective frequency was 2--4 hz and the maximal effective frequency 12 hz. the secretory response to vagal stimulation was ... | 1979 | 33532 |
| enhancement of the viscosity of mucin by serum albumin. | the interaction of serum albumin with a model epithelial mucin from pig stomach was explored by rotary viscometry. during 30 min of incubation of human serum albumin(20mg/ml) and pig gastric mucin (8mg/ml) in iso-osmotic buffers at 37 degrees c, the solution became markedly viscous. viscosity enhancement was proportional to albumin concentration (2-40mg/ml), was most pronounced under conditions of low shear rate (less than 45s-1), and was considerably greater than the additive or multiplicative ... | 1978 | 33658 |
| synthesis of chloromethyl ketone derivatives of fatty acids. their use as specific inhibitors of acetoacetyl-coenzyme a thiolase, cholesterol biosynthesis and fatty acid synthesis. | a general route for the synthesis of chloromethyl ketone derivatives of fatty acids is described. 5-chloro-4-oxopentanoic acid, 7-chloro-6-oxoheptanoic acid, 9-chloro-8-oxononanoic acid and 11-chloro-10-oxoundecanoic acid were synthesized by this method and tested as covalent inhibitors of pig heart acetoacetyl-coa thiolase. the k1 decreased by approx. 20-fold for each pair of methylenes added to the chain length, showing that the initial stage in inhibitor binding occurs at a non-polar region o ... | 1978 | 33667 |
| [action of some gastric antisecretory drugs on histamine h2-receptors (author's transl)]. | a series of compounds endowed with gastric antisecretory activity were examined for their possible effects on histamine h2 receptors in different experimental conditions. the data obtained suggest that, apart from cimetidine, all the other compounds are devoid of antagonistic properties on h2 receptors. the inhibitory effect observed in some of the examined preparations is probably connected with unspecific actions. | 1978 | 33682 |
| [effect of 8-n-phenethyl-1-oxa-2-oxo-3,8-diazaspiro(4,5)decane hydrochloride (decaspiride) on histamine receptors]. | | 1978 | 33688 |
| exchange of free and bound coenzyme of flavin enzymes studied with [14c]fad. | the exchange of bound fad for free fad was studied with d-amino acid oxidase (d-amino acid:oxygen oxidoreductase (deaminating), ec 1.4.3.3) and beta-d-glucose oxidase (beta-d-glucose:oxygen 1-oxidoreductase, ec 1.1.3.4). for a simple measurement of the reaction rate, equimolar amounts of the enzyme and [14c]fad were mixed. the exchange occurred very rapidly in the holoenzyme of d-amino acid oxidase at 25 degrees c, ph 8.3 (half life of the exchange: 0.8 min), but slowly in the presence of the su ... | 1979 | 33712 |
| lack of primary defect in maldescended testis of the neonatal pig. | | 1978 | 33732 |
| characterization of hypophysiotropic hormones in porcine hypothalamic extracts. | | 1978 | 33800 |
| isoelectric focusing of thyroid-stimulating antibody of graves' disease. | | 1978 | 33803 |
| [antihistaminic and antiserotonin properties of new complex tropine esters]. | the antihistaminic and antiserotonin properties of 16 new tropine esters, analogues of atropine, tropacin and tropaphen, were studied. all of them were found to lessen the spasmogenic effects of histamine and serotonin. the intensity of the antihistaminic and antiserotonin action of the drugs varied depending upon the structure of the radical at the alpha-carbon atom in the acidic part of the molecule. both types of the activity are most marked in the desoxymethyl propyl and butyl analogues of a ... | 1979 | 33829 |
| [tetrahydropyridoazepine and tetrahydropyridoazepinone derivatives. i. derivatives of 2,3,4,5-tetrahydro-1h-pyrido[3,2b]azepine and of the corresponding lactam]. | preparation of n-derivatives of 2,3,4,5-tetrahydro-1h-pyrido[3,2-b]azepine and, in one case, of 2,3,4,5-tetrahydro-1h-pyrido[3,2-b]azepine-2-one was achieved by introducing the substituents cocl, conh2, co2(ch2)3n(ch3)2, coch2br and (ch2)3n(ch3)2. the pharmacological results indicate some effect on the ans. | 1978 | 33830 |
| kinetics and mechanism of action of aldehyde reductase from pig kidney. | | 1978 | 33851 |
| differences between 15-hydroxyprostaglandin dehydrogenase from pig placenta and human placenta [proceedings]. | | 1978 | 33855 |
| proceedings of the international embryo transfer society. fifth annual conference - 14-16 january, 1979. | | 1979 | 33864 |
| [proteolytic activity of the human gastric juice]. | | 1979 | 33883 |
| comparison of two pig intestinal brush border peptidases with the corresponding renal enzymes. | intestinal dipeptidyl peptidase iv and gamma-glutamyltransferase were compared to the corresponding kidney enzymes with respect to immunological and electrophoretic properties. the influences of selected effectors on the two enzymes were also studied. the two kidney peptidases exhibited the reaction of total identity with the corresponding intestinal enzymes in immunodiffusion. furthermore, the intestinal dipeptidyl peptidase iv and gamma-glutamyl transferase showed the same inhibition patterns ... | 1979 | 33889 |
| anesthesia of swine under field conditions. | | 1979 | 33956 |
| glycoproteins and blood group activity. oligosaccharides of a+ hog submaxillary glycoproteins. | | 1979 | 33982 |
| superoxide radical as an intermediate in the oxidation of hydroxylamines by mixed function amine oxidase. | | 1979 | 34088 |
| the effect of muscarine on cholinoceptive neurones subserving the peristaltic reflex of guinea-pig isolated ileum. | | 1978 | 34117 |
| transport function of hypothalamic tanycyte ependyma: how good is the evidence? | | 1978 | 34122 |
| absence of tyrosine hydroxylase activity and dopamine beta-hydroxylase immunoreactivity in intrinsic nerves of the guinea-pig ileum. | | 1979 | 34125 |
| [biochemical aspects of acute cadmium poisoning in pigs]. | | 1978 | 34254 |
| [microbiology of various liver products]. | the proportions of mesophilic, thermophilic and psychrophilic microorganisms were investigated in the total number of microbes and aerobic sporogenic microorganisms in delicatessen liver sausages and liver cheeses. at the same time the content of ammonia and the ph of the products were determined. the largest part of the microflora comprised mesophilic microorganisms, 10 to 25% of which belonged to the sporogenic microflora. the incidence of staphylococci, enterococci and coliform microorganisms ... | 1979 | 34256 |
| a sensitive method for the assay of guanylate cyclase activity. | a method for the assay of guanylate cyclase is described utilizing alpha-[32p]-gtp as substrate for the enzyme reaction. 100-150 microgram of enzyme protein is incubated in a 15.6 mm tris-hcl buffer incubation mixture, ph 7.6. the reaction is stopped by the addition of edta. the [32p]-cyclic gmp formed is separated by a two-step column chromatography on dowex 50w-x4 ion-exchange resin and neutral alumina. the recovery for cyclic gmp was about 70%. the blank values ranged from 0.001-0.003% of the ... | 1978 | 34307 |
| the role of the colostrum in relation to immunity and survival in the newborn ruminant and pig. a seminar held in the institut national agronomique de paris-grignon, 78850 thiverval-grignon, france. april 25, 26 and 27th 1978. | | 1978 | 34350 |
| [h2-antihistaminics, iii: synthesis and h2-antihistaminic activity of sulfoxides and sulfones analogous to metiamide (author's transl)]. | | 1979 | 34376 |
| the role of link-protein in the structure of cartilage proteoglycan aggregates. | proteoglycan fractions were prepared from pig laryngeal cartilage. the effect of link-protein on the properties of proteoglycan-hyaluronate aggregates was examined by viscometry and analytical ultracentrifugation. aggregates containing link-protein were more stable than link-free aggregates at neutral ph, at temperatures up to 50 degrees c and in urea (up to 4.0m). oligosaccharides of hyaluronate were able to displace proteoglycans from link-free aggregates, but not from the link-stabilized aggr ... | 1979 | 34388 |
| cooperative binding of coenzyme in d-amino acid oxidase. | | 1979 | 34428 |
| studies on the structure-activity relationship of adrenergic beta-mimetic benzylamine derivatives. iv.1) aryl-substituted 1-aminotetralins and 1-aminoindans. | | 1978 | 34486 |
| induction of spermatogenesis in the naturally cryptorchid pig. | abdominal testes of adult, naturally unilaterally cryptorchid boars were subjected to continuous artificial cooling for 5, 15, 25, or 45 days. this treatment initiated development of the spermatogenic epithelium. after a cooling period of 45 days there was complete differentiation in many seminiferous tubules. the results indicate that the spermatogenic arrest in abdominally located testes is not due to an inborn defect in the testis, but is caused by the maintenance of the testis at the abdomin ... | 1979 | 34533 |
| n-hydroxyamino acids. irreversible inhibitors of pyridoxal 5'-phosphate enzymes and substrates of d- and l-amino acid oxidases. | | 1979 | 34607 |
| percutaneous absorption: in vivo experiments. | the percutaneous absorption of esters of nicotinic acid has been studied in vivo in man. the time for erythema to be produced has been measured both when the ester is applied continuously and in 'pulse' experiments when the ester is removed before the erythema develops. the results show that the erythema is produced long before steady state diffusion across the epidermis is established and the penetration of methyl nicotinate is characterized by d/l2 = 2.3 x 10(-4)s-1 where d is the diffusion co ... | 1979 | 34686 |
| pentobarbitone and skeletal muscle contractions: on the interaction with the effect elicited by the beta-adrenoceptor agonist, terbutaline. | the soleus, a slow-contracting muscle, and the extensor digitorum longus (edl), a fast-contracting muscle from guinea-pig were prepared for isometric recording in vitro. subtetanic contractions were evoked by transmural field-stimulation. pentobarbitone increased the force of contraction in both muscles. in the soleus it shifted the stimulation frequency-response curve to the left. terbutaline caused a decrease in the force of subtetanic contractions of the soleus, an effect which was dependent ... | 1979 | 34691 |
| the inhibitory effects of sex steroid hormones on electrically-induced contractions of the guinea-pig isolated ileum. | | 1979 | 34699 |
| evaluation of beta adrenoceptor antagonist affinity and cardioselectivity by radioligand-receptor assay. | | 1979 | 34714 |
| pharmacological properties of histamine-sensitive adenylate cyclase from mammalian brain. | | 1979 | 34718 |
| beta-adrenoceptor studies. 5. 1h nmr and ir spectroscopic analysis of the conformation of the hydrohalide salts of beta-adrenoceptor-blocking aryloxypropanolamines. evidence for a seven-membered ring structure with participation of two hydrogen bonds. | | 1979 | 34723 |
| alphaviruses in peninusular malaysia: i. virus isolations and animal serology. | a survey of the activity of three alphaviruses (sindbis, getah and chikungunya) in peninsular malaysia was conducted between 1962 and 1970. serum samples were examined from 3,917 vertebrates representing a wide variety of wild and domestic animals throughout the peninsula for hemagglutination-inhibiting and neutralizing antibodies. a total of 548,939 mosquitoes were collected from different habitats, including jungle, rural, suburban and urban areas, and the majority of the females taken were ex ... | 1978 | 34888 |
| [ribonuclease of cultured young pig kidney cells]. | two alkaline rnases and three forms of the enzyme are detected in the cell cytoplasm of the pigling kidney culture transplanted line (ib-rs-2) by gel filtration through sephadex g-100, g-150 and by chromatography on molselect se-50. the former two rnases are in complex with the enzyme inhibitor and the latter three forms manifest their action in the ph acid region. | 1978 | 34909 |
| effects of beta-adrenoceptor agonists on airway smooth muscle and on slow-contracting skeletal muscle: in vitro and in vivo results compared. | ten beta-adrenoceptor agonists were examined with respect to a) relaxation of pilocarpine-contracted trachea and depression of contractions of the soleus muscle of the guinea-pig in vitro and b) counteraction of histamine-induced bronchospasm and depression of contractions of the soleus muscle of the cat in vivo. there was a close correlation between the results obtained in vitro and results obtained on the corresponding tissues in vivo in spite of the different species used. a close correlation ... | 1979 | 34976 |
| electrogenesis of the plateau and pacemaker potential. | | 1979 | 35092 |