| disseminated oesophagostomiasis in the rhesus monkey. | disseminated oesophagostomiasis was diagnosed at necropsy of 5 rhesus monkeys (macaca mulatta). nodular lesions were in visceral organs as well as in the colon and mesentery. lesions varied greatly with respect to degree of organ involvement and damage due to parasite invasion. in 2 monkeys, nodular lesions were in the colon, mesentery, liver, kidneys, abdominal wall, urinary bladder, and uterus; in 1 of these 2 monkeys, a nodular lesion inhabited by a parasite was in a lung. the ectopic nodules ... | 1975 | 126218 |
| detailed time course of ovum transport in the rhesus monkey (macaca mulatta). | | 1975 | 130170 |
| glycolytic control mechanisms in myometrium from pregnant rhesus monkeys. | | 1975 | 130943 |
| proceedings: neuromuscular and cardiovascular studies with dimethyl tubocurarine in anaesthetized cats, rhesus monkeys and man. | | 1976 | 130951 |
| plasma levels of unconjugated steroids in male baboons (papio hamadryas) and rhesus monkeys (macaca mulatta). | in an attempt to find suitable animal models to aid in the study of the reproductive processes of the human male, plasma levels of unconjugated pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, 20alpha-dihydroprogesterone, 17-hydroxyprogesterone, androstenedione, testosterone, dihydrotestosterone, oestrone and oestradiol were measured in 18 male baboons and 10 male rhesus monkeys and the steroid levels were compared with those previously established in normospermic, middle-aged men. ... | 1976 | 132836 |
| epizootic staphylococcal infections in subhuman primates after surgical operation. | in late october, 1974, staphylococcus aureus postoperative wound infection was recorded in a nonhuman primate (macaca mulatta) which had recently undergone surgical operation. infection in a second monkey appeared approximately 2 weeks later, and a clustering of 6 cases appeared over the next 3-week period. the clinical spectrum included septicemia in 2 monkeys and skin infection at the surgical incision site of several others. investigation revealed a uniform and consistent association of a pha ... | 1976 | 132881 |
| fetal lung lecithin metabolism in the glucose-intolerant rhesus monkey pregnancy. | fetal lung lecithin metabolism was examined in rhesus monkey gestations complicated by glucose intolerance secondary to maternal streptozotocin (stz) administration. fetuses of stz-treated mothers were delivered at 85% to 89% of term and were compared to two control groups of fetuses from normal pregnancies--one group age-matched to the stz pregnancies, and the other composed of fetuses delivered in the final 10% of gestation. in the glucose-intolerant pregnancies, two measures of fetal lung lec ... | 1976 | 133326 |
| attempted experimental cross infections with mammalian guinea-worms, dracunculus spp. (nematoda: dracunculoidea). | dracunculus medinensis and d. insignis are morphologically indistinguishable. experiments to test the susceptibility of various mammalian hosts to these two guinea worm species are described. infective 3rd-stage larvae of d. medinensis were administered to each of four raccons (procyon lotor): infective 3rd-stage larvae of d. insignis were administered to a rhesus monkey (macaca mulatta), two dogs, two ferrets (mustela putorius furo), and a marten (martes americana). d. medinensis was not found ... | 1976 | 134642 |
| properties and physiological effects of thermal carbon black. | studies have been carried out to determine the possible physiological effects of contact with carbon black made by the thermal process. contact was made by ingestion, skin application and/or inhalation. ingestion and/or skin application do not appear to lead to any changes from the normal. inhalation exposures do not produce pulmonary function changes (antemortem or postmortem studies) but may lead to moderate to severe "perifocal" emphysema in rhesus monkeys (not observed in guinea pigs). inhal ... | 1976 | 136503 |
| laparoscopy in macaca mulatta: specialized equipment employed and initial observations. | laparoscopy in rhesus monkeys and specialized equipment developed or adapted for this procedure are described. repeated laparoscopy in the same animal throughout the menstrual cycle showed by morphological and hormonal criteria that this technique does not significantly influence follicular growth, ovulation, luteal function or cycle length. observations of the side of ovulation and other follicle/corpus luteum relationships are also described. | 1976 | 136512 |
| [the immunobiology of m-proteins of streptococcus pyogenes. iii. immunization of rhesus monkeys (macaca mulatta)]. | rhesus monkeys were used for the examination of immunogenicity of various preparations of m-antigens of streptococcus pyogenes, types 1, 12, and 19. the antigens were applied in various dosages, but always with alumniumhydroxide as adjuvant. the challenge infection was provided by the homologous type, in some cases by an additional heterologous type. after intravenous infection all the animals fell ill, as the high dose of infective agents led to poisoning. the majority of immunized animals, how ... | 1976 | 136887 |
| fetal pancreatic glucagon responses in glucose-intolerant nonhuman primate pregnancy. | rhesus monkey pancreatic alpha-cell function in streptozotoc-induced glucose-intolerant pregnancy is similar to that in normal primate pregnancy. specifically, basal maternal and fetal plasma glucagon levels equate, and the fetal alpha cell does not respond to the glucagonogenic stimulus of either intravenous alanine or insulin-induced hypoglycemia. this contrasts with the accelerated maturation of the fetal beta cell in glucose-intolerant pregnancy, and does not support the concept of functiona ... | 1977 | 138366 |
| anatomically orthogonal qrs electrocardiogram of the baboon (papio hamadryas) and the macaque (macaca mulatta). sex and species differences. | peak amplitudes of the qrs complex were evaluated in 28 adult macaques (macaca mulatta) and 28 adult baboons (papio hamadryas), using two anatomically orthogonal lead systems. the anteroposterior (z) and the transversal (x) component of the cardiac electric field was smaller in females than in males. comparison of qrs amplitudes in baboons and macaques indicates that the loop of the spatial vectorcardiogram is situated further ventrally and to the right in the former. the relationship between ve ... | 1977 | 140402 |
| influence of matching for rhla (sd) antigens and of mixed lymphocyte reactivity on allograft survival in unrelated rhesus monkeys. | | 1977 | 141128 |
| the complete haemogram and phagocytic activity in rhesus monkeys (macaca mulatta). | | 1977 | 141678 |
| transient postocclusive renal vasospasm in conscious rhesus monkeys. | transient postocclusive renal vasospasm occurred in nine conscious postoperative monkeys with electromagnetic flowmeters implanted on the left renal artery. during an interval of 5-7 days, beginning approximately 1 wk after the implantation of an electromagnetic flowmeter and pneumatic occlusive cuff on the renal artery, occlusions produced by 2- to 15-s inflations of the cuff were invariably followed by flow reduction of 40%-90%, which began 30-60 s after occlusion and lasted from 3 to 60 min. ... | 1977 | 144441 |
| muscle spindles in nonhuman primate extrinsic auricular muscles. | muscle spindles were sought in peri-auricular muscles of several primate species (rhesus monkey, woolly monkey, and baboon). transverse sections cut at 10 mu and stained primarily by a silver impregnation technique were examined using light microscopy. spindles were identified on the basis of standard criteria. posterior and/or superior auricular muscles of each species were found to contain spindles. at least some muscles innervated by facial nerve have classical spindles as component structure ... | 1977 | 144446 |
| topical bioavailability of a potential anti-acne agent (sc-23110) as determined by cumulative excretion and areas under plasma concentration time curves. | the topical bioavailability of a potential anti-acne agent ([14c]-sc-23110) was determined in the rhesus monkey, an animal model relevant to man. by the method of cumulative excretion in urine and feces the percutaneous absorption of 21 microgram/cm2 of the free base form was determined to be 0.58 +/- 0.16 (sd) percent of the applied dose. the mean areas under the plasma concentration time curves (auc) following topical and intravenous administration were also determined. the ratior of the auc's ... | 1978 | 146056 |
| serum levels of testicular and adrenal steroids after dexamethasone adn hcg-administration in the laboratory-maintained rhesus monkey. | | 1978 | 146998 |
| studies in the monkey (macaca mulatta) on the effect of (+/-)-6-fluorotryptophan and (+/-)-p-chlorophenylalanine on plasma tryptophan [proceedings]. | | 1978 | 147717 |
| karyological and electron-microscopic studies in myocardial cells of primates after experimentally induced cardiac hypertrophy. | precocious polyploidization in hypertrophic hearts of infants with congenital malformation can be reproduced banding the ascending aorta of young rhesus monkeys. electron micrographs show hypoxic changes, signs of dna, rna, and protein synthesis as well as degenerative changes comparable to human hearts. enforced polyploidization of cor pulmonale is found in rhesus exposed to coal quartz dust for 48 months. the pig heart, containing disturbed mitoses, serves as a model for incomplete mitoses. du ... | 1977 | 149202 |
| hormonal regulation of ovarian folliculogenesis in rhesus monkeys: i. concentrations of serum luteinizing hormone and progesterone during laparoscopy and patterns of follicular development during successive menstrual cycles. | | 1978 | 149571 |
| spontaneously occurring hypertension in wild rhesus monkeys. | in this study naturally occurring hypertension in wild rhesus monkeys has been noted with a frequency of 13 out of 428 monkeys examined. the maximum systolic/diastolic blood pressure was 242/140 mm of hg. clinically there was evidence of grade i retinopathy in one case only, otherwise the animals did not manifest any symptom to suggest illness. biochemical examination revealed normal plasma angiotensin activity but the level of serum sodium was slightly elevated. the serum potassium, blood urea ... | 1975 | 151170 |
| serological matching for d locus antigens improves kidney allograft survival in rhesus monkeys. | a prospective study performed in unrelated, unimmunized rhesus monkeys revealed that serological matching for d-associated ia1 antigens improves kidney allograft prognosis, provided that the recipients are nonreactive in mixed lymphocyte cultures (mlc) against their donors. mlc-negative host-donor combinations showed a more than 3-fold increase in the mean survival time as compared with mlc-positive combinations. apparently, compatibility for the most important mlc-stimulating determinants is re ... | 1978 | 151948 |
| immunologic study of t and b lymphocytes in thymectomized monkeys after irradiation and autologous bone marrow transplantation. | rhesus monkeys were exposed to total-body gamma-irradiation (60co) with 700r following adult thymectomy, and then protected with autologous bone marrow. transplantation immunity in txibm animals was impaired: skin allografts survived for 19 to 38 days. the percentage of t and b lymphocytes studied by the rosette technique and immunofluorescent staining for ig did not substantially change when examined in early as well as late periods after txibm. functional capacities of lymphocytes were measure ... | 1978 | 153246 |
| effect of implant duration on in vivo sensitivity of electromagnetic flow transducers. | twenty-three electromagnetic flow transducers with lumen diameters of 3.5-6.0 mm were implanted in rhesus monkeys and baboonss for 12 h to 120 days. each flow transducer was calibrated 1) in vitro on dialysis tubing with saline before implantation, 2) in vivo the last day of the implant period, and 3) again in vitro after the flow transducer was recovered. three other flow transducers were implanted on femoral arteries of baboon just central to an arteriovenous silastic shunt, and were calibrate ... | 1979 | 154848 |
| histochemical characteristics of the masseter and temporalis muscles of the rhesus monkey (macaca mulatta). | the histochemical characteristics, cross-sectional area and capillary of the skeletal muscle fibers of the anterior and posterior regions of the superficial masseter and the temporalis muscles are described for juvenile and adult rhesus monkeys of both sexes. slow twitch fatigue resistant (s), fast twitch fatigue resistant (fr) and fast twitch fatigable (ff) fibers were found in varying proportions throughout the muscles; however some fibers with an intermediate myofibrillar atpase activity were ... | 1979 | 154857 |
| reduced t cell reactivity in vasectomized rhesus monkeys: association with histocompatibility type. | the capacity of peripheral lymphocytes from rhesus monkeys which had been vasectomized for 7 or 11 years to stimulate and respond to normal rhesus lymphocytes in mixed lymphocyte cultures (mlc) was tested to determine whether vasectomy affects immunologic reactivity. the ability to respond in mlc, a t cell function, was significantly reduced in the 11-year vasectomized animals and in two 7-year vasectomized animals. the ability to stimulate in mlc, a b cell function, was significantly increased ... | 1979 | 155014 |
| are d and dr antigens identical? a review of available data for man and the rhesus monkey. | | 1979 | 156430 |
| the rhla complex of rhesus monkeys. xi: positive mlc reactions between identical sibs caused by alloimmunization. | d-locus identical pairs of monkeys were alloimmunized. an exchange of skin and blood between initially mlc-negative unrelated monkeys frequently led to strong mutual reactivity in mixed cultures. this was not the case when rhla identical siblings were similarly (mutually) immunized. these data led to the postulation of a second rhla-linked mlc locus, named d', which exerts its influence only after alloimmunization. interestingly, strong mlc responsiveness between the rhla identical siblings coul ... | 1979 | 156969 |
| [absorption, body distribution, metabolism, and excretion of dieldrin in non-human primates and other laboratory animals (author's transl)]. | using 14c-labelled dieldrin, the resorption, body distribution, and rate of excretion as well as the metabolism was investigated qualitatively and quantitatively. the experiments with mice, rats, rabbits, rhesus monkeys, and chimpanzees were performed under identical conditions to obtain reliably comparable results. | 1979 | 156995 |
| monoamines and sexual behaviour in non-human primates. | the experiments described were concerned with elucidating the involvement of monoamines in the sexual behaviour of rhesus monkeys. the measurement of perturbations in the levels and turnover of the acid metabolites of serotonin and dopamine in cisternal cerebrospinal fluid, occurring in response to hormonal manipulations which alter proceptivity and receptivity, has not clarified the ways in which hormones and amines interact. however, the use of psychoactive drugs which alter the activity of mo ... | 1978 | 157266 |
| toxicology studies in mice, beagle dogs and rhesus monkeys given chlorozotocin (nsc 178, 248). | chlorozotocin was studied for toxic effects in beagle dogs and rhesus monkeys. the results are the subject of this report. the compound was administered i.v. as single and 5 daily doses in dogs and monkeys; and, in dogs, as 10 consecutive daily doses, once weekly for 6 weeks and for 5 daily doses followed by 9 days rest repeated 3 times. the most prominent toxicities in both species were dose-related renal tubular lesions. these appeared as a necrosis at the most toxic levels and a nephrosis at ... | 1979 | 157561 |
| influence of blood transfusions and matching for dr antigens on kidney allograft survival in unrelated rhesus monkeys. | kidney transplantations were performed in unrelated, immunosuppressed rhesus monkeys matched for two dr antigens and given five pretransplant transfusion of whole blood. the host-donor combinations were either reactive or nonreactive in mixed lymphocyte culture (mlc) and shared up to three a and b locus antigens with their blood and kidney donors. although previous monkey experiments had shown a definite positive influence of dr matching as well as of pretransplant transfusions on graft survival ... | 1979 | 158241 |
| differentiation and regulation of peripheral androgen metabolism in rats and rhesus monkeys. | the sex-unique metabolic network for steroids is induced neonatally in male rats. the metabolic clearance rates (mcr) of dehydroepiandrosterone and testosterone are similar for both sexes of rats despite quantitatively significant sex differences in individual enzyme activities of adults; neonatally androgenized females had a 2-to 3-fold increase in mcr but cyproterone had no effect. the mcrt and mcrdha of castrated adult male rhesus monkeys are the same as those of normal males; the mcrdha is 4 ... | 1979 | 159625 |
| the migration of 111indium-labelled polymorphonuclear leucocytes into the oral cavity in the rhesus monkey. | | 1979 | 161583 |
| resuscitation of the monkey brain after one hour's complete ischemia. ii. brain water and electrolytes. | adult normothermic rhesus monkeys were submitted to one hour's complete cerebral ischemia, followed by periods of blood recirculation varying from 45 min to 24 h. the functional impact of ischemia and the subsequent recovery was monitored by electrophysiological recording and a distinction was made between animals with signs of functional recovery and animals without recovery. prior to ischemia the water content of the gray matter was 81.1 plus or minus 0.3% (mean plus or minus s.d.) and of the ... | 1975 | 162836 |
| responses of primate spinothalamic tract neurons to electrical stimulation of hindlimb peripheral nerves. | the responses of spinothalamic tract neurons were studied by extra- and intracellular recordings from the lumbosacral spinal cord in anesthetized rhesus monkeys (macaca mulatta). the neurons were identified by antidromic activation from the contralateral diencephalon. they were then classified by the mildest form of mechanical stimulation applied to the ipsilateral hindlimb. the effects of electrical stimulation of the nerve(s) supplying the receptive field were investigated. graded electrical s ... | 1975 | 162940 |
| an electron microscopic study of virus particles in rhesus monkey placenta. | examination of chorionic villi from rhesus monkey placenta revealed the presence of c-type virus particles budding from syncytial trophoblast, pericytes, hofbauer cells, and mesenchyme. in addition, particles, were found budding from cells of the cytotrophoblastic cell column and decidual basalis. they measured 30 nm in diameter, had a dense central core, surrounded by a narrow, electron-lucent zone, and were enclosed by an outer unit membrane. | 1975 | 164011 |
| protein deficiency in carbon tetrachloride-induced hepatic lesions. | the influence of protein deficiency on the hepatotoxicity of carbon tetrachloride (ccl4) was investigated in a group of rhesus monkeys. animals fed a protein-rich diet served as controls. the results indicate that protein-deficiency protects the liver against acute hepatotoxicity of this drug. the protective effect is abolished if the animals are administered phenobarbital prior to the administration of ccl4. the protective action is due to a reduction, in protein deficiency, of the endoplas ... | 1975 | 164171 |
| physicochemical characterization of rhesus low density lipoproteins. | the serum low density lipoprotein (ldl; p 1.019-1.050 g/ml) of the normal macaca mulatta monkey (rhesus), kept on a low-fat purina primate chow diet, was isolated by ultracentrifugal flotation, and its physicochemical properties were compared with those previously reported for human ldl. rhesus ldl was found to be chemically similar to human ldl. the values for the sedimentation (s25, w-o) and diffusion (d25,w-o) coefficients were 7.09 s and 2.50 times 10- minus-7 cm-2 sec- minus-1, respectively ... | 1975 | 164895 |
| comparison of the lipopretein profiles and the effect of n-phenylpropyl-n-benzyloxy acetamide in primates (38473). | analytical ultracentrifugation showed cebus and rhesus monkeys had two low density components while only one was present in squirrel monkeys. in untreated or w1372 treated monkeys, neither chylomicrons nor very low density lipoproteins were detected on analytical ultracentrifugation. chylomicrons were not observed on agarose gel electrophoresis. ultracentrifugal analysis showed w1372 treatment decreased the amount of ldl in all animals and also the hdl in cebus monkeys on an atherogenic diet. bo ... | 1975 | 165529 |
| the effect of nicotinic acid on the metabolism of the plasma lipoproteins of rhesus monkeys. | the effect of nicotinic acid was investigated in rhesus monkeys. subcutaneous injections of nicotinic acid lower the plasma very low density lipoprotein (vvldl) and low density lipoprotein (hdl) concentration. the fall in ldl concentration is not accompained by any change in the lipid or protein composition of either lipoprotein. analysis by sephadex gel chromatography and polyacrylamide-gel electrophoresis showed that the proteins of monkey vldl and ldl are qualitatively similar to those of hum ... | 1975 | 165824 |
| induction of cholangiocarcinoma following treatment of a rhesus monkey with aflatoxin. | | 1975 | 166028 |
| experimental cerebral vasospasm and cyclic adenosine monophosphate (c-amp). | blood induced acute and chronic cerebral vasospasm were studied in rhesus monkeys by serial angiography. two vasoactive agents were evaluated. in acute spasm, phosphodiesterase inhibition by aminophylline consistently reversed the vasospasm. this agent alone was ineffective in chronic spasm and required the addition of isoproterenol to produce reversal of vasospasm. it is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-amp in vascular smooth muscle which ... | 1975 | 166052 |
| restricted sleep regime in rhesus monkeys: differential effect of one night's sleep loss and selective rem deprivation. | | 1975 | 166263 |
| immunofluorescent demonstration of plasma protein entry into arterial wall by cholesterol, epinephrine, norepinephrine and angiotensin ii. | thepresence of igg and beta-lipoprotein in thoracic and abdominal aortas of 33 rhesus monkeys under various conditions was observed by immunofluorescence and interference filter technique. in untreated and placebo control monkeys, a definite fluorescence due to igg was seen in highly limited areas of the subendothelial space and the innermost layers and a weak but positive fluorescence due to beta-lipoprotein was sometimes show in highly limited spots of the subendothelial space, but not the med ... | 1975 | 166554 |
| effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas. | pretreatment of human fibroblast cultures with human leukocyte interferon (hif, 1,000 iu/ml) resulted in a 24-h delay of virus replication after infection with vaccinia virus and herpes simplex virus type 1 and type 2. additional hif treatment 24 h after infection effectively lowered the maximum yield of viral infectivity. equal results were obtained in simian cells with 3,000 iu of hif per ml. the spread of two cell-bound herpesviruses, varicella zoster virus and medical lake macaque herpesviru ... | 1975 | 166924 |
| multiple herpesvirus simiae isolation from a rhesus monkey which died of cerebral infarction. | a rhesus monkey housed in the new england regional primate research center for more than 4 yr died after an illness of 19 da. clinical signs included central nervous system involvement and ulcers on the labial mucosa. microscopically, the cause of death was established as multiple cerebral infarction. lesions characteristic of herpesvirus infections were not present in the brain nor in any other tissue; however, herpesvirus simiae was isolated from oral and anal swabs as well as from tongue and ... | 1975 | 167229 |
| specific immune adherence assay for human hepatitis a antibody application to diagnostic and epidemiologic investigations. | a specific immune adherence (ia) test for hepatitis a antibody in human serum was described employing liver extract of marmosets infected with cr326 strain human hepatitis a virus. persons with hepatitis a, but not hepatitis b, developed hepatitis a ia antibody soon after onset of the acute illness and this persisted thereafter. there was very close agreement in the tests for human hepatitis a immune adherence, complement fixing (cf) and neutralizing antibodies. ia antibodies appeared to develop ... | 1975 | 167376 |
| mammalian liver alcohol dehydrogenases. | literature on the properties of liver alcohol dehydrogenase (adh) from man, horse and rat is reviewed and discussed under two major headings: 1) physical and chemical properties of adh and 2) structure-function relationship in isoenzymes. under the first heading are discussed: molecular weight, subunit composition catalytic sites per molecule, sulfhydryl groups, end groups, amino acid composition, role of zn++ in the structure and function, coenzyme specificity and binding, conformational change ... | 1975 | 167554 |
| age changes in the pubic symphysis of macaca mulatta. | age changes in the pubic symphyses of 142 cayo santiago rhesus monkeys (known age, sex and maternal genealogy) are described. symphyseal development is sexually dimorphic. males generate a ridge and furrow system which is gradually replaced by a solid ankylosis at the mid-sagittal plane. female development parallels that of the male until puberty. with pregnancy and delivery, relaxation and reaggregation of pelvic ligaments binding the symphysis destroy the symphyseal face. continued bearing of ... | 1975 | 167589 |
| control of hepatic glycogen metabolism in the rhesus monkey: effect of glucose, insulin, and glucagon administration. | the effects of intravenous glucose, insulin and glucagon admininistration on the hepatic glycogen synthase and glycogen phosphorylase systems were assessed in the anesthetized rhesus monkey. results were correlated with measurements of hepatic cyclic amp (camp) concentrations and plasma glucose, insulin, and glucagon concentrations. both glucose and insulin administration promoted significant inactivation of phosphorylase by 1 min, which was followed by more gradual activation of synthase. neit ... | 1975 | 167592 |
| isolation and partial characterization of the major apolipoprotein component of bovine serum high density lipoprotein. | the delipidated protein component of bovine serum high density lipoprotein was fractionated by gel filtration on a sephadex g-150 column (equilibrated with buffer containing 6 m urea) into three fractions: i, ii and iii. fractions i and ii together constitute 88% of all the protein weight of bovine high density lipoprotein, whereas fraction iii accounts for the remaining 12%. analysis of the fractions by sodium dodecyl sulfate-polyacrylamide electrophoresis reveals that fraction i consists mostl ... | 1975 | 167837 |
| complete and apparently specif local tumor regression using syngeneic or xenogeneic "tumor-immune" rna extracts. | syngeneic and xenogeneic rna-rich extracts of lymphoid tissues were used in an immunotherapeutic regimen to treat strain 2 guinea pigs that were given intradermal injections of a uniformly lethal dose (1 x 10(6)) of line 10 diethylnitrosamine-induced transplantable hepatoma cells. when 1 x 10(7) syngeneic nonsensitive peritoneal exudate cells, 2.5 mg rna from line 10-immune strain 2 guinea pigs or line 10-immune rhesus monkeys, and 1.0 mg of a line-10 tumor-specific antigen preparation were inje ... | 1975 | 167938 |
| complete klüver-bucy syndrome in man. | a 22 year old right-handed man suffered a viral meningoencephalitis, possibly herpetic, resulting in bilateral damage to the temporal lobes as confirmed by appropriate clinical, electrophysiological and neuroradiological studies. extended clinical neuropsychological evaluation documented all the characteristic features of the syndrome described by klüver and bucy following bilateral ablation of the temporal lobes in adult rhesus monkeys, including "psychic blindness," oral exploration, hypermeta ... | 1975 | 168031 |
| immunological relationship between delta herpesvirus of patas monkeys and varicells-zoster virus of humans. | the delta herpesvirus (dhv) which produced outbreaks of exanthematous disease in patas monkeys was shown to have a close immunological relationship to varicella-zoster (v-z) virus of man. immunization of rhesus monkeys with dhv or v-z virus resulted in the development of neutralizing antibodies to both viruses and also in the production of complement-fixing antibodies to v-z virus. immunoglobulin m neutralizing antibody to v-z virus was demonstrated in the serum of a rhesus monkey immunized with ... | 1975 | 168152 |
| the isolation of monkey b virus (herpesvirus simiae) from the trigeminal ganglia of a healthy seropositive rhesus monkey. | | 1975 | 169266 |
| augmentation of lymphocyte cytotoxicity by antibody to herpesvirus saimiri associated antigens. | sera from owl monkeys infected with herpesvirus saimiri (hvs) mediated antibody-dependent lymphocyte cytotoxicity (adlc) against virus-infected owl monkey kidney cells. peripheral blood lymphocytes from rhesus monkeys served as effector cells in this cytotoxic assay. adlc titers increased along with membrane immunofluorescence (mf) titers but among some sera, the adlc titers were much higher than expected from the mf titers, suggesting that multiple serum factors were involved in mediating adlc ... | 1975 | 169525 |
| neutralizing antibody responses to varicella-zoster virus. | neutralization of varicella-zoster (v-z) virus by human sera and immune rhesus monkey sera was enhanced by fresh guinea pig complement. there was no marked difference in the degree to which complement enhanced neutralization by sera from current v-z virus infections and sera from long-past varicella infections. immunoglobulin g neutralizing antibody in sera from varicella cases was enhanced by complement to a slightly higher degree than was immunoglobulin m (igm) antibody, and immunoglobulin g n ... | 1975 | 170206 |
| characterization of monkey peripheral neutrophil granules during infection. | rhesus monkey (macaca mulatta) neutrophils were shown to contain the azurophilic granule maker enzymes myeloperoxidase and beta-glucuronidase but were deficient in the specific granule markers alkaline phosphatase (akp) and lysozyme. isopycnic centrifugation of leukocyte homogenates on linear sucrose gradients resulted in cosedimentation of myeloperoxidase and beta-glucuronidase with an equilibrium density of 1.18. after an intravenous inoculation of monkeys with salmonella typhimurium akp activ ... | 1975 | 170208 |
| cytoplasmic inclusions of neurons in the monkey visual cortex (area 19). | several unusual neuronal inclusions were found in certain cells of the rhesus monkey visual cortex (area 19): 1. filamentous bodies, present in the small stellate cells of layer iv, globoid, 0.3-0.6 mum in diameter, consisting of fine 50 a filaments in a hexagonal meshwork. these are often associated with the labyrinthine bodies. 2. labyrinthine bodies found exclusively in the small stellate cells of layer iv, including certain neurons with dispersed ribosomes. these are 0.4-0.7 mum in diameter ... | 1975 | 170843 |
| malignant lymphoma resembling burkitt's tumour in rhesus monkeys: (light- and electron microscopic studies). | spontaneous tumours of the haematopoetic system have been only rarely observed in nonhuman primates. we had the opportunity to carry out light and electron microscopic investigations of three lymphomas in immature rhesus monkeys from our colony. all animals had tumours of both retroperitoneum and lymph nodes. the relatively uniform lymphoblastic or lymphoreticular tumour cells as well as the massive occurence of the so-called "starry sky macrophages" were histologically characteristic. histochem ... | 1975 | 170906 |
| isolation of foamy virus from rhesus, african green and cynomolgus monkey leukocytes. | foamy virus (fv) was recovered regularly from the leukocyte of rhesus and cynomolgus monkeys and somewhat less often from african green monkey leukocytes. virus was found in virtually all organs of experimentally infected rhesus monkeys. no illness or pathologic abnormalities were noted in these animals or in any of the naturally infected animals in spite of the prolonged period of viral persistence in various organs and tissues. | 1975 | 171409 |
| triton induced hyperlipoproteinemia in rhesus monkeys. | | 1975 | 172443 |
| effects of collagenase upon the intervertebral disc in monkeys. | the authors studied 5 rhesus monkeys for the effects of annulotomy, with or without the addition of a bacterially-derived collagenase into the nuclear-evacuated centrum of lumbar intervertebral discs. the animals were sacrificed from 3 weeks to 21 months after the single or staged double procedures. the earliest radiographic changes were loss of height of the interspace at 7 days, erosion of the vertebral body margins at 3 weeks, malalignment at 6 weeks, osteophytic formation at 3 1/2 months, sc ... | 1976 | 172611 |
| immune adherence and complement-fixation tests for human hepatitis a. diagnostic and epidemiologic investigations. | the reliable propagation of cr326 strain of human hepatitis a virus in saguinus mystax marmosets has permitted the development of specific serum neutralization, complement-fixation (cf), and immune adherence (ia) assays for hepatitis a antigen and antibody. the cf and ia assays were made possible by the use of livers of cr326-infected marmosets as a source of hepatitis a antigen. all assays were shown to be specific for hepatitis a. cases of hepatitis b did not show development of hepatitis a an ... | 1975 | 173600 |
| the mythology of various hepatitis a virus isolates. | several types of viral hepatitis may exist. hepatitis a (ms-1 type) can be transmitted to marmosets and chimpanzees. virus-like particles, which may be parvo- or enteroviruses and which have been demonstrated in feces of this type of hepatitis, do not share cross-reacting antigens with hepatitis b but do cross-react with fecal hepatitis a antigen. hepatitis a (gb type), which also does not cross-react with hepatitis b, is not antigenically identical with ms-1; it can be transmitted to marmosets ... | 1975 | 173601 |
| a rhesus monkey model for the study of bolivian hemorrhagic fever. | two groups of rhesus monkeys were inoculated with either 10(5) (group 1) or 10(3) (group 2) plaque-forming units of machupo virus, the etiologic virus of bolivian hemorrhagic fever. the monkeys were observed for clinical signs; body temperatures, viremias, hematologic changes, and virus-neutralizing antibody were measured. the onset of clinical signs for groups 1 and 2 occurred on days 4-6 and 7-10, respectively, with fever, anorexia, and depression. these and other signs became more severe, and ... | 1976 | 173762 |
| effect of acute inhibition of adrenocorticotrophin secretion on plasma corticosteroids in the rhesus monkey (macaca mulatta). | the half-life of plasma cortisol in the rhesus monkey (m. mulatta), determined by two methods, was about 130 min and longer than that in man; it was unaffected by administration of dexamethasone. dexamethasone (5 mg, i.v.) immediately inhibited the secretion of acth from the monkey pituitary. the plasma half-life of nh2-terminal immunoreactive acth was found to be about 55 min which was much longer than the biological half-life. the adrenal synthesis of cortisol was inhibited by metyrapone which ... | 1975 | 173773 |
| natural and experimentally induced antibodies to defined mammalian type-c virus proteins in primates. | using sensitive radiommunoprecipitation assays for highly purified type-c rna tumor virus proteins, we found that 5 of 16 clinically normal gibbons (including 4 of 5 normal animals from a colony with 2 cases of lymphoma) and 4 of 4 experimentally inoculated gibbons formed antibodies to the major structural protein (p30) of gibbon ape leukemia virus (galv). an additional woolly monkey immunized with the closely related simian sarcoma virus also formed antibodies detectable with galv p30. of 20 pa ... | 1975 | 173868 |
| diaphragmatic herniation of the liver in macaques demonstrated by intravenous hepatography. | a suspected diagnosis of diaphragmatic herniation of the liver in 2 monkeys (macaca fascicularis and macaca mulatta) was confirmed radiographically by using various contrast media. experimental compound ag 60.99, which is selectively concentrated in the liver and spleen, allowed excellent visualization of these 2 organs and confirmed the presence of a portion of the liver in the right thorax. cholografin meglumine was subsequently utilized to determine the location of the gall bladder. other pot ... | 1975 | 173919 |
| coronary artery fine structure in rhesus monkeys: the early atherosclerotic lesion and its progression. | | 1976 | 174072 |
| the cerebrospinal fluid: current concepts of its formation. | until recently it has been generally accepted that the choroid plexuses are the major source of the cerebrospinal fluid (csf). however, data now indicate that significant contributions to the csf are made at extrachoroidal sites. csf production studies and 24na transport studies in normal and plexectomized rhesus monkeys supportive of substantial extrachoroidal csf formation will be presented. although the exact mechanisms of csf formation remain to be defined, ultrafiltration is probably involv ... | 1976 | 174480 |
| cyclic amp in developing muscle of the rhesus monkey: effect of prostaglandin e. | cyclic amp levels, measured by a competitive protein-binding assay and by a prelabeling technique with adenine-14 c, were determined on fetal, infant, and adult heart, diaphragm, and skeletal muscle of the rhesus monkey (macaca mulatta); the effect of pge on cyclic amp accumulation was also studied. the levels of cyclic amp were higher in the 3 types of muscle from 150-day fetuses (91% of term) than in adult muscles and even higher at 78-100 days fetal age, and histological evidence indicated th ... | 1976 | 174762 |
| control of glycolysis in skeletal muscle from fetal rhesus monkeys. | in our studies of metabolic control mechanisms in skeletal muscle from rhesus fetus we have determined the tissue levels of the metabolic intermediates and cofactors of the glycolytic pathway and have calculated the mass-action ratios for each reaction. skeletal muscle from rhesus fetuses (macaca mulatta), 90-155 days of gestational age, and from adult rhesus monkeys was used in these experiments. the apparent equilibrium constants for hexokinase and phosphofructokinase (pfk) in these tissues we ... | 1976 | 175343 |
| cells in regions of rhesus monkey brain and pituitary retain radioactive estradiol, corticosterone and cortisol differentially. | | 1976 | 175885 |
| cyclic amp phosphodiesterase activity in fetal and adult muscle of the rhesus monkey. | | 1976 | 176071 |
| recovery of herpes simiae (b virus) from both primary and latent infections in rhesus monkeys. | the suspected ability of herpes simiae (b virus) to persist in a latent form has been confirmed in rhesus monkeys. the virus was recovered from primary oral lesions of 2 young monkeys and again, 6 months after disappearance of symptoms, from cultures of gasserian ganglia taken from the same individuals. b virus was identified by its effects in vivo and in vitro and in cross neutralization tests with antisera to reference b virus and herpes simplex virus. tests showed that the same virus was pres ... | 1975 | 177038 |
| antigenic characterization of intermediate adenovirus 14-11 strains associated with upper respiratory illness in a military camp. | an unusual variant of adenovirus (av) 11 was isolated from throat and rectal swabs from six persons with upper respiratory illness in a spanish military camp in march 1969. the same strain was serologically related to the upper respiratory illness of seven other men among 25 sample cases studied in detail. after strain purification, the virus was grouped as an av by standard biological tests; it possessed the usual titers of group-specific hexon antigen but only low hemagglutinin titers (1:4 to ... | 1976 | 177365 |
| multiple testing for the detection of b virus antibody in specially handled rhesus monkeys after capture from virgin trapping grounds. | eight groups of rhesus monkeys totaling over 1,000 animals were captured in the virgin trapping grounds of jammu and kashmir, india. individual caging and special handling technics were utilized to prevent cross-contamination during capture, holding, and subsequent shipment to quarantine facilities in the united states. immediately following the arrival of the monkeys, 5 consecutive blood samples were obtained at approximately 2-wk intervals, and the sera were rested for neutralizing antibody ag ... | 1976 | 177807 |
| characterization of the plasma lipoproteins and apoproteins of the erythrocebus patas monkey. | patas monkey lipoproteins were fractionated into four distinct classes by a combination of ultracentrifugation and geon-pevikon block electrophoresis and characterized with respect to their chemical and physical properties. very low density lipoproteins (vldl) were isolated at d is less than 1.006, were triglyceride rich, and were in the size range 300-850 a. they were similar in apoprotein content to the vldl of man, dog, and swine. the patas monkey low density lipoprotein referred to as ldl-i ... | 1976 | 178359 |
| comparative sensitivity of the bgm cell line for isolation of enteric viruses. | the bgm line of african green monkey kidney cells was less sensitive than primary rhesus monkey kidney cells or human fetal diploid kidney cells for isolation of certain echoviruses and adenoviruses from fecal specimens. | 1976 | 178630 |
| maturation in vitro of oocytes recovered from prepubertal rhesus monkeys. | | 1976 | 178865 |
| the nonhuman primates as models for studying human atherosclerosis: studies on the chimpanzee, the baboon and the rhesus macacus. | there is no dearth of experimental techniques for producing the hyperlipoproteinemia resulting in atherosclerotic complications and for myocardial infarction in the non human primates. most of the recent experiments which have given information of great value have been studied with relatively expensive animals for a long period of time up to 6-7 years. it is evident that no animal model perfectly duplicates the human disease or satisfies all desirable requirements. the chimpanzees, representativ ... | 1976 | 179299 |
| effective antiviral prophylaxis and therapy by systemic application of human interferon in immunosuppressed monkeys. | rhesus monkeys treated with antilymphocytic globulin were infected with vaccinia virus or with medical lake macaque herpesvirus. at the sites of inoculation of vaccinia virus, animals not treated with interferon developed typical pustulous reactions and then smaller secondary lesions. human leukocyte interferon (5 x 10(5) international units per day) injected intramuscularly, either from one day before to three days after infection or for seven days beginning on the first day of primary reaction ... | 1976 | 180202 |
| prophylactic control of simian hemorrhagic fever in monkeys by an interferon inducer, polyriboinosinic-polyribocytidylic acid-poly-l-lysine. | a nuclease-resistant complex of polyriboinosinic-polyribocytidylic acid containing poly-l-lysine and carboxymethylcellulose was used as prophylactic treatment of simian hemorrhagic fever in rhesus monkeys. this infection has proven uniformly fatal to more than 50 monkeys. treatment 8 hr before infection and repeatedly thereafter completely prevented the development of viremia and death. untreated animals died before development of antibodies to the virus. none of the treated animals developed an ... | 1976 | 180207 |
| complete regression of a guinea pig hepatocarcinoma by immunotherapy with "tumor-immune" rna or antibody to fibrin fragment e. | two novel immunotherapeutic regimens were developed for a uniformly lethal, intradermally growing transplantable ascites variant (line 10) of a diethylnitrosamine-induced hepatoma in strain 2 guinea pigs. in an apparently tumor-specific immunotherapy model, 32 guinea pigs were cured by the injection into the tumor area, five or seven days after tumor challenge, of syngeneic or xenogeneic rna extracts obtained from lymphoid tissues of line 10-immune strain 2 guinea pigs or rhesus monkeys, as part ... | 1976 | 181352 |
| pathology of chronic bolivian hemorrhagic fever in the rhesus monkey. | gross and microscopic lesions of bolivian hemorrhagic fever (bhf) are described in 10 rhesus monkeys that survived from 30 to 78 days after subcutaneous inoculation with a dose of 10(3) plaque-forming units (pfu) of machupo virus, a dose which produces a severe and generally fatal disease. six of the monkeys had been given low doses of homologous immune globulin when initial signs of infection appeared. monkeys exhibited clinical signs in two phases. the initial signs of acute infection which be ... | 1976 | 181994 |
| infection of wild and laboratory animals with machupo and latino viruses. | natural infection with machupo and latino viruses occurs only in the cricetine rodent calomys callosus. machupo virus induces fatal infection in suckling mice and hamsters, and in adult guinea-pigs, marmosets, and rhesus monkeys. latino virus kills only suckling hamsters; it produces chronic but non-viraemic infection in calomys rodents.machupo virus, in contrast, induces a viraemic immunotolerant infection in suckling calomys, and a split response in animals more than 9 days of age. tolerant in ... | 1975 | 182399 |
| status of arenavirus vaccines and their application. | a limited but definite need exists for vaccines against lassa, junin, and machupo viruses. medical and laboratory personnel, as well as defined high-risk population groups, require protection from these highly virulent agents. to date little work has been done on inactivated vaccines for these viruses. a live attenuated junin vaccine has been tested successfully in more than 600 persons, and a high-passage machupo virus strain has protected rhesus monkeys against lethal infection produced by a h ... | 1975 | 182407 |
| effect of indomethacin on cyclic amp phosphodiesterase activity in myometrium from pregnant rhesus monkeys. | our results indicate that indomethacin inhibits cyclic amp phosphodiesterase in the myometrium of the pregnant rhesus monkey under in vitro as well as in vivo conditions. kinetic data on extracts of myometrium from pregnant rhesus monkeys indicated two cyclic amp phosphodiesterase activities. the apparent km value for the high affinity enzyme averaged 3.9 mum and for the low affinity enzyme 23 mum; the vmax values averaged 0.56 and 1.4 nmoles cyclic amp hydrolized per mg protein min-1 respective ... | 1976 | 183237 |
| comparative epidemiological aspects of naturally occurring malignant lymphoma in domestic cats and rhesus monkeys. | | 1975 | 183676 |
| a new serum lipoprotein found in many rhesus monkeys. | | 1976 | 183769 |
| cardiovascular and neuromuscular effects of dimethyl tubocurarine in anaesthetized cats and rhesus monkeys. | intravenous dose-response relationships for dimethyl tubocurarine showed that vagal blockade only became appreciable (50-83%) at doses 8-16 times those sufficient for full neuromuscular paralysis in anaesthetized cats (0.0625 mg/kg) and rhesus monkeys (0.125 mg/kg); heart rate was unchanged. sympathetic function was unimpaired by supramaximal paralysing doses of 0.5 and 1 mg/kg in cats, but was reduced (20-41%) by comparable neuromuscular paralysing doses of 1 and 2 mg/kg in rhesus monkeys; thes ... | 1976 | 183800 |
| rhesus monkeys kidney cells persistently infected with simian virus 40: production of defective interfering virus and acquisition of the transformed phenotype. | monolayer cultures of llc-mk2 rhesus monkey kidney cells became persistently infected with simian virus 40 (sv40) when infected at a multiplicity of infection of 100 plaque-forming units/cell. a stable carrier state developed characterized by extensive viral proliferation without obvious cytopathic effect other than the slow growth of these cultures. by 11 weeks all cells produced the sv40 t antigen. in contrast, less than 5% of the cells produced v antigen. virus-free clonal isolates were obtai ... | 1976 | 184052 |
| replication of murine paramyxoviruses in hamster tracheal organ culture and comparison with standard tissue culture methods. | replication of sendai virus, pneumonia virus of mice, and sv5 was investigated in tracheal organ cultures from 2- to 4-day-old and 2- and 4-week-old hamsters, and viral infectivity in tracheal explants was compared with that in tissue culture monolayers. explants from 2- to 4-day-old hamsters produced higher titers of the three paramyxoviruses, as detected by hemadsorption with guinea pig and murine erythrocytes in primary rhesus monkey kidney cells. tracheal cultures from 2- and 4-week-old hams ... | 1976 | 184110 |
| stimulation of proliferation in stationary primary cultures of monkey aortic smooth muscle cells. part 2. effect of varying concentrations of hyperlipemic serum and low density lipoproteins of varying dietary fat origins. | the outgrowth of medial explants of thoracic aorta from rhesus monkeys has used to study the influence of hyperlipemic serum on cell proliferation. after 5-6 weeks of rapid growth in bme plus 10% normal serum, the cultures reach a stationary phase during which they show little mitotic activity. when it replaces 5% of the normal serum in the media, hyperlipemic serum induces another proliferative phase in the cultures, as measured by [3h1thymidine incorporation and increase in culture area. low d ... | 1976 | 184801 |
| potentiation of the acth response to metyrapone by l-dopa in the monkey. | the intravenous injection of l-dopa (15 mg/kg) to monkeys (macaca mulatta) failed to alter plasma concentrations of acth and of 11-deoxy-cortisol. when cortisol synthesis was blocked with iv metyrapone, potentiation of acth secretion by l-dopa became apparent. simultaneous injection of l-dopa and metyrapone resulted in a marked increase in plasma acth from 93 +/- 18 pg/ml to 432 +/- 80 pg/ml, whereas plasma 11-deoxycortisol increased from 1.5 +/- 0.2 mug/100 ml to 14.6 +/- 1.0 mug/100 ml 90 min ... | 1976 | 185048 |
| neurovirulence testing of oral poliovaccine in the rhesus monkey. | | 1976 | 186408 |