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ige reactivity and cross-reactivity of japanese monkeys (macaca fuscata) to japanese cedar (cryptomeria japonica) and cypress (chamaecyparis obtusa) pollen allergens.the natural occurrence of japanese cedar (cryptomeria japonica, cj) pollinosis has been reported in japanese monkeys (macaca fuscata). however, the reactivity to japanese cypress (chamaecyparis obtusa, co) pollen allergens in these monkeys has not yet been reported.199910336604
ige reactivity and cross-reactivity of japanese monkeys (macaca fuscata) to japanese cedar (cryptomeria japonica) and cypress (chamaecyparis obtusa) pollen allergens.the natural occurrence of japanese cedar (cryptomeria japonica, cj) pollinosis has been reported in japanese monkeys (macaca fuscata). however, the reactivity to japanese cypress (chamaecyparis obtusa, co) pollen allergens in these monkeys has not yet been reported.199910336604
detection of entamoeba dispar dna in macaque feces by polymerase chain reaction.we used the polymerase chain reaction (pcr) to determine the prevalence of entamoeba histolytica and e. dispar in the wild population of macaque monkeys (macaca fuscata) in mt. takasaki, oita prefecture, japan. of the 101 samples collected, 41 (42.57%) were found to be positive for e. dispar. however, no e. histolytica was detected from the collected samples. the results of this survey demonstrate the high prevalence of e. dispar in macaque monkeys in the study area. moreover, they provide addit ...199910344544
urine as another potential source for template dna in polymerase chain reaction (pcr).this technical note examines the potential for preparing template dna in polymerase chain reactions (pcr) from urine in japanese macaques (macaca fuscata). microsatellite band patterns from urine samples showed close agreement with those of blood and fecal samples, and only a few hundred microl of urine yielded a template dna for pcr. this research will increase the opportunity for scientists to examine the genetic backgrounds of their target animals by using non-invasive sample collection in th ...199910402038
angiographic and histologic effects of fundus photodynamic therapy with a hydrophilic sensitizer (mono-l-aspartyl chlorin e6).to demonstrate the efficacy of the photosensitizer mono-l-aspartyl chlorin e6 (npe6) in closing choroidal vessels at low energy levels, that tissue uptake and clearance are rapid, and that low concentrations of drug are needed to achieve clinical effects.199910406627
angiographic and histologic effects of fundus photodynamic therapy with a hydrophilic sensitizer (mono-l-aspartyl chlorin e6).to demonstrate the efficacy of the photosensitizer mono-l-aspartyl chlorin e6 (npe6) in closing choroidal vessels at low energy levels, that tissue uptake and clearance are rapid, and that low concentrations of drug are needed to achieve clinical effects.199910406627
reproductive termination in female japanese monkeys: a comparative life history perspective.this study explores the question of reproductive termination (loss of reproductive ability) in female japanese macaques (macaca fuscata) from the arashiyama west (texas) troop. we used a large sample of completed lives to identify reproductively terminated female japanese macaques and to consider reproductive termination in japanese macaques from a comparative life history perspective, which permits meaningful comparisons to be made with human female menopause. we classified a female as reproduc ...199910423262
reproductive termination in female japanese monkeys: a comparative life history perspective.this study explores the question of reproductive termination (loss of reproductive ability) in female japanese macaques (macaca fuscata) from the arashiyama west (texas) troop. we used a large sample of completed lives to identify reproductively terminated female japanese macaques and to consider reproductive termination in japanese macaques from a comparative life history perspective, which permits meaningful comparisons to be made with human female menopause. we classified a female as reproduc ...199910423262
the incidence of japanese cedar pollinosis and sensitization to the pollen allergens among japanese monkeys in a troop.the natural occurrence of japanese cedar (cryptomeria japonica; cj) pollinosis has been reported in japanese monkeys (macaca fuscata), an appropriate animal model for developing antipollinosis therapies. however, there has been no study on the incidence of japanese cedar pollinosis in monkeys. to evaluate the incidence of cj pollinosis in japanese monkeys, we investigated the presence of pollinosis symptoms among monkeys in a troop, and the response to cj allergens in pollinosis monkeys. we exam ...199910447752
the incidence of japanese cedar pollinosis and sensitization to the pollen allergens among japanese monkeys in a troop.the natural occurrence of japanese cedar (cryptomeria japonica; cj) pollinosis has been reported in japanese monkeys (macaca fuscata), an appropriate animal model for developing antipollinosis therapies. however, there has been no study on the incidence of japanese cedar pollinosis in monkeys. to evaluate the incidence of cj pollinosis in japanese monkeys, we investigated the presence of pollinosis symptoms among monkeys in a troop, and the response to cj allergens in pollinosis monkeys. we exam ...199910447752
the incidence of japanese cedar pollinosis and sensitization to the pollen allergens among japanese monkeys in a troop.the natural occurrence of japanese cedar (cryptomeria japonica; cj) pollinosis has been reported in japanese monkeys (macaca fuscata), an appropriate animal model for developing antipollinosis therapies. however, there has been no study on the incidence of japanese cedar pollinosis in monkeys. to evaluate the incidence of cj pollinosis in japanese monkeys, we investigated the presence of pollinosis symptoms among monkeys in a troop, and the response to cj allergens in pollinosis monkeys. we exam ...199910447776
the incidence of japanese cedar pollinosis and sensitization to the pollen allergens among japanese monkeys in a troop.the natural occurrence of japanese cedar (cryptomeria japonica; cj) pollinosis has been reported in japanese monkeys (macaca fuscata), an appropriate animal model for developing antipollinosis therapies. however, there has been no study on the incidence of japanese cedar pollinosis in monkeys. to evaluate the incidence of cj pollinosis in japanese monkeys, we investigated the presence of pollinosis symptoms among monkeys in a troop, and the response to cj allergens in pollinosis monkeys. we exam ...199910447776
can macaques perceive place of articulation from formant transition information?an important problem in speech perception is to determine how humans extract the perceptually invariant place of articulation information in the speech wave across variable acoustic contexts. although analyses have been developed that attempted to classify the voiced stops /b/ versus /d/ from stimulus onset information, most of the human perceptual research to date suggests that formant transition information is more important than onset information. the purpose of the present study was to deter ...199910462798
cloning and sequencing of the cdna species for mammalian dimeric dihydrodiol dehydrogenases.cynomolgus and japanese monkey kidneys, dog and pig livers and rabbit lens contain dimeric dihydrodiol dehydrogenase (ec 1.3.1.20) associated with high carbonyl reductase activity. here we have isolated cdna species for the dimeric enzymes by reverse transcriptase-pcr from human intestine in addition to the above five animal tissues. the amino acid sequences deduced from the monkey, pig and dog cdna species perfectly matched the partial sequences of peptides digested from the respective enzymes ...199910477285
evaluation of reaction of primate brain to grafted pc12 cells.intrastriatal implantation of polymer-encapsulated pc12 cells, which constitute a dopaminergic cell line derived from rat pheochromocytoma, has proved useful for ameliorating parkinsonian symptoms in several kinds of animals. in considering the clinical application of this technique, we should make sure that pc12 cells are rejected completely by the host immune system in case the capsule breaks. in the present study, unencapsulated pc12 cells were injected into the brain of japanese monkeys (mac ...199910478724
evaluation of reaction of primate brain to grafted pc12 cells.intrastriatal implantation of polymer-encapsulated pc12 cells, which constitute a dopaminergic cell line derived from rat pheochromocytoma, has proved useful for ameliorating parkinsonian symptoms in several kinds of animals. in considering the clinical application of this technique, we should make sure that pc12 cells are rejected completely by the host immune system in case the capsule breaks. in the present study, unencapsulated pc12 cells were injected into the brain of japanese monkeys (mac ...199910478724
human is a unique species among primates in terms of telomere length.trf (terminal restriction fragments) length in various tissues of non-human primates such as macaca mulatta (rhesus monkey), macaca fuscata (japanese monkey), macaca fascicularis (crab-eating monkey), pan troglodytes (common chimpanzee), and pongo pygmaeus (orangutan) was at least 23 kb without exception, which was quite different from that of human somatic tissues (smaller than 10 kb). the distribution pattern of telomerase activity among tissues was similar between human and non-human primates ...199910491289
the innervation of outer hair cells: 3d reconstruction from tem serial sections in the japanese macaque.transmission electron micrographs from serial sections were obtained from the neural pole of outer hair cells (ohcs) in the japanese macaque (macaca fuscata) and reconstructions of nerve terminals were made using computer software. data are based on observations of six cells in the basal turn, eight in the middle turn and four in the apex. in general, the number of afferent (type ii) terminals on each ohc increased from base to apex, and for a given turn, the numbers appeared unrelated to ohc ro ...199910491951
fibrous structure of connective tissue in the vocal fold of the japanese monkey (macaca fuscata).fibrous structures in the vocal fold were studied in 8 adult japanese monkeys. their vocal folds were fixed with formalin and longitudinal and cross-sections were prepared. some of the samples were treated with 10% naoh to digest cellular components and elastic fibers, and some of them were treated with 90% formic acid to digest cellular components and collagen fibers. each sample was then fixed with oso4, dehydrated, dried at the critical point, ion-coated, and studied under a scanning electron ...199910502963
fibrous structure of connective tissue in the vocal fold of the japanese monkey (macaca fuscata).fibrous structures in the vocal fold were studied in 8 adult japanese monkeys. their vocal folds were fixed with formalin and longitudinal and cross-sections were prepared. some of the samples were treated with 10% naoh to digest cellular components and elastic fibers, and some of them were treated with 90% formic acid to digest cellular components and collagen fibers. each sample was then fixed with oso4, dehydrated, dried at the critical point, ion-coated, and studied under a scanning electron ...199910502963
social rank and sex-biased maternal investment in captive japanese macaques: behavioural and reproductive data.this study investigated the relationship between social rank and sex-biased maternal investment in captive japanese macaques (macaca fuscata) using reproductive and behavioural data. high-ranking mothers showed a significantly male-biased secondary sex ratio, spent more time in contact with and carried male infants for longer than female infants. low-ranking mothers showed no bias in secondary sex ratio nor in the time spent in contact with male and female infants, but carried female infants for ...199910567830
fatal measles virus infection in japanese macaques (macaca fuscata).an outbreak of natural measles virus infection occurred in a group of japanese macaques (macaca fuscata). over a period of 4 months, 12 of 53 japanese macaques died following a 2-23-day history of anorexia, diarrhea, and dermatitis. the monkeys were kept in outdoor exhibits but had been moved temporarily into indoor caging and then transferred to new outdoor exhibits. ten monkeys died while they were in temporary caging, and two monkeys died after they were moved to new outdoor exhibits. the dia ...199910568440
free-field audiogram of the japanese macaque (macaca fuscata).the audiograms of three japanese macaques and seven humans were determined in a free-field environment using loudspeakers. the monkeys and humans were tested using tones ranging from 8 hz to 40 khz and 4 hz to 22.4 khz, respectively. at a level of 60 db sound pressure level the monkeys were able to hear tones extending from 28 hz to 37 khz with their best sensitivity of 1 db occurring at 4 khz. the human 60-db hearing range extended from 31 hz to 17.6 khz with a best sensitivity of -10 db at 2 a ...199910573911
sensitization to grass, ragweed, mugwort pollen allergens in japanese monkeys (macaca fuscata): preliminary report.the natural occurrence of japanese cedar (cj, cryptomeria japonica) pollinosis has been reported in japanese monkeys (macaca fuscata). furthermore, most of these monkeys with cj pollinosis have immunoglobulin (ig) e sensitization to japanese cypress (chamaecyparis obtusa) pollen. however, specific ige to other pollens has not yet been reported.199910594546
sensitization to grass, ragweed, mugwort pollen allergens in japanese monkeys (macaca fuscata): preliminary report.the natural occurrence of japanese cedar (cj, cryptomeria japonica) pollinosis has been reported in japanese monkeys (macaca fuscata). furthermore, most of these monkeys with cj pollinosis have immunoglobulin (ig) e sensitization to japanese cypress (chamaecyparis obtusa) pollen. however, specific ige to other pollens has not yet been reported.199910594546
disynaptic pyramidal excitation in forelimb motoneurons mediated via c(3)-c(4) propriospinal neurons in the macaca fuscata.in contrast to findings in the cat, it recently has been shown that disynaptic pyramidal epsps only rarely are observed in forelimb motoneurons of the macaque monkey in the intact spinal cord or after a corticospinal transection in c(5). this finding has been taken to indicate that the disynaptic pyramidal excitatory pathway via c(3)-c(4) propriospinal neurons (pns) is weakened through phylogeny when the monosynaptic cortico-motoneuronal connection has been strengthened. we reinvestigate this is ...199910601484
species-specific tt viruses and cross-species infection in nonhuman primates.viruses resembling human tt virus (ttv) were searched for in sera from nonhuman primates by pcr with primers deduced from well-conserved areas in the untranslated region. ttv dna was detected in 102 (98%) of 104 chimpanzees, 9 (90%) of 10 japanese macaques, 4 (100%) of 4 red-bellied tamarins, 5 (83%) of 6 cotton-top tamarins, and 5 (100%) of 5 douroucoulis tested. analysis of the amplification products of 90 to 106 nucleotides revealed ttv dna sequences specific for each species, with a decreasi ...200010627523
activity of smooth pursuit-related neurons in the monkey periarcuate cortex during pursuit and passive whole-body rotation.smooth pursuit and vestibularly induced eye movements interact to maintain the accuracy of eye movements in space (i.e., gaze). to understand the role played by the frontal eye fields in pursuit-vestibular interactions, we examined activity of 110 neurons in the periarcuate areas of head-stabilized japanese monkeys during pursuit eye movements and passive whole-body rotation. the majority (92%) responded with the peak of their modulation near peak stimulus velocity during suppression of the vest ...200010634896
activity of smooth pursuit-related neurons in the monkey periarcuate cortex during pursuit and passive whole-body rotation.smooth pursuit and vestibularly induced eye movements interact to maintain the accuracy of eye movements in space (i.e., gaze). to understand the role played by the frontal eye fields in pursuit-vestibular interactions, we examined activity of 110 neurons in the periarcuate areas of head-stabilized japanese monkeys during pursuit eye movements and passive whole-body rotation. the majority (92%) responded with the peak of their modulation near peak stimulus velocity during suppression of the vest ...200010634896
sural--lateral plantar nerve communications in japanese macaque.it is generally accepted that the sural nerve in humans contains exclusively sensory and autonomic fibers. recently, however, a few clinical reports have suggested that the human sural nerve contains motor fibers. on the other hand, it is known that motor fibers are present in the sural nerve of rats and dogs, and that the fibers reach intrinsic muscles of the foot via a communicating branch to the lateral plantar nerve. the author investigated the communicating branch between the sural and late ...199910659577
the effect of marker frequency disparity on the discrimination of gap duration in monkeys.duration-discrimination thresholds of the silent interval (gap) between two successive tones (markers) were measured in four japanese monkeys. the task was serial discrimination, and monkeys were required to release the lever when the gap duration decreased from 200 ms. monkeys successfully acquired the task, and gap thresholds of monkeys were revealed to be larger than previous data with human subjects. gap thresholds were not affected by marker frequency when the two markers were identical in ...199910664785
the effect of marker frequency disparity on the discrimination of gap duration in monkeys.duration-discrimination thresholds of the silent interval (gap) between two successive tones (markers) were measured in four japanese monkeys. the task was serial discrimination, and monkeys were required to release the lever when the gap duration decreased from 200 ms. monkeys successfully acquired the task, and gap thresholds of monkeys were revealed to be larger than previous data with human subjects. gap thresholds were not affected by marker frequency when the two markers were identical in ...199910664785
malaria infection induces rapid elevation of the soluble fas ligand level in serum and subsequent t lymphocytopenia: possible factors responsible for the differences in susceptibility of two species of macaca monkeys to plasmodium coatneyi infection.the intraerythrocytic stage of the simian malaria parasite plasmodium coatneyi (cdc strain) was intravenously inoculated into two species of macaques with different susceptibilities to infection with this parasite, including four japanese macaques (macaca fuscata) and three cynomolgus macaques (m. fascicularis). the japanese macaques infected with p. coatneyi developed severe clinical manifestations similar to those of severe human malaria and eventually became moribund, while the infected cynom ...200010678924
cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys.although brain cell viability depends largely on cerebral circulation, mechanisms of blood flow control, such as autoregulation, or of the pathogenesis of functionally impaired blood supply to brain regions, such as in cerebral vasospasm after subarachnoid hemorrhage, have not been clearly defined. our recent studies support the hypothesis that nitric oxide, released from nitrergic nerves, plays a crucial role as a neurotransmitter in vasodilating cerebral arteries from primate and subprimate ma ...200010683579
cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys.although brain cell viability depends largely on cerebral circulation, mechanisms of blood flow control, such as autoregulation, or of the pathogenesis of functionally impaired blood supply to brain regions, such as in cerebral vasospasm after subarachnoid hemorrhage, have not been clearly defined. our recent studies support the hypothesis that nitric oxide, released from nitrergic nerves, plays a crucial role as a neurotransmitter in vasodilating cerebral arteries from primate and subprimate ma ...200010683579
subdural applications of no scavenger or no blocker to the cerebellum depress the adaptation of monkey post-saccadic smooth pursuit eye movements.we examined pharmacologically whether cerebellar long-term depression (ltd) may play a role in the adaptation of smooth pursuit eye movements in two macaca fuscata, which were trained to pursue a target moving in the horizontal plane in a 3 degrees step-10 deg/s ramp mode. the monkeys showed small catch-up saccades followed by 6-8 deg/s post-saccadic pursuit movements. adaptation of the post-saccadic pursuit velocity was induced by repetition of acceleration of the target to 20 deg/s after the c ...200010683844
bilateral receptive field neurons and callosal connections in the somatosensory cortex.earlier studies recording single neuronal activity with bilateral receptive fields in the primary somatosensory cortex of monkeys and cats agreed that the bilateral receptive fields were related exclusively to the body midline and that the ipsilateral information reaches the cortex via callosal connections since they are dense in the cortical region representing the midline structures of the body while practically absent in the regions representing the distal extremities. we recently found a sub ...200010724460
bilateral receptive field neurons and callosal connections in the somatosensory cortex.earlier studies recording single neuronal activity with bilateral receptive fields in the primary somatosensory cortex of monkeys and cats agreed that the bilateral receptive fields were related exclusively to the body midline and that the ipsilateral information reaches the cortex via callosal connections since they are dense in the cortical region representing the midline structures of the body while practically absent in the regions representing the distal extremities. we recently found a sub ...200010724460
specialized basement membrane of monkey maturation stage ameloblasts mediates firm ameloblast-enamel association by its partial calcification.a basement membrane-like structure associated with the maturation stage ameloblasts of the monkey (macaca fuscata) tooth germ was examined with high resolution electron microscopy. the tissue was prepared either with or without demineralization. this structure was composed of a lamina lucida-like (lamina lucida) and lamina densa-like (lamina densa) structure. the latter was made up of a fine "cord" network, the major constituent of the basement membrane. it was closely associated with the third ...200010742445
ultrastructural verification of anchoring role of lamina fibroreticularis of dental basement membrane in odontogenesis.in a previous study of the developing tooth a characteristic fibrillar layer associated with the basement membrane of the inner enamel epithelium was found to be a highly specialized lamina fibroreticularis of the basement membrane which is unusually rich in basotubules, 10 nm wide microfibril-like structures. in this study this layer was further examined in detail in the hope of ultrastructurally elucidating its role in odontogenesis. tooth germs of the monkey (macaca fuscata) were processed fo ...199910742957
role of the pretectal nucleus of the optic tract in short-latency ocular following responses in monkeys.when a large-field image is suddenly moved in front of an observer, an ocular following response (ofr) with short latency (<60 ms in monkey and <85 ms in human) is observed. previous studies have shown that neurons in the pretectal nucleus of the optic tract (not) of the monkey respond to movements of large-field visual stimuli. to understand the potential role of the not in the ofr, we first recorded single-unit activity in the not of four monkeys (macaca fuscata). sixty-six not neurons preferr ...200010789943
transplantation of cryopreserved mouse, chinese hamster, rabbit, japanese monkey and rat ovaries into rat recipients.partial ovaries from mice, hamsters, rabbits, japanese monkeys and rats have survived deep-freezing and returned to a normal morphological state after being thawed and transplanted into the rat uterine cavity. this report describes the ice-free cryopreservation of mouse and other ovaries at -196 degrees c by vitrification. the vitrification solution was based on the solutions reported by rall & fahy [16]. after ovaries had been exposed to the vitrification solution, they were frozen, with their ...200010803357
transplantation of cryopreserved mouse, chinese hamster, rabbit, japanese monkey and rat ovaries into rat recipients.partial ovaries from mice, hamsters, rabbits, japanese monkeys and rats have survived deep-freezing and returned to a normal morphological state after being thawed and transplanted into the rat uterine cavity. this report describes the ice-free cryopreservation of mouse and other ovaries at -196 degrees c by vitrification. the vitrification solution was based on the solutions reported by rall & fahy [16]. after ovaries had been exposed to the vitrification solution, they were frozen, with their ...200010803357
parietal neurons represent surface orientation from the gradient of binocular disparity.in order to elucidate the neural mechanisms involved in the perception of the three-dimensional (3d) orientation of a surface, we trained monkeys to discriminate the 3d orientation of a surface from binocular disparity cues using a go/no-go type delayed-matching-to-sample (dmts) task and examined the properties of the surface-orientation-selective (sos) neurons. we recorded 57 sos neurons from the caudal part of the lateral bank of the intraparietal sulcus (area cip) of three hemispheres of two ...200010805708
parietal neurons represent surface orientation from the gradient of binocular disparity.in order to elucidate the neural mechanisms involved in the perception of the three-dimensional (3d) orientation of a surface, we trained monkeys to discriminate the 3d orientation of a surface from binocular disparity cues using a go/no-go type delayed-matching-to-sample (dmts) task and examined the properties of the surface-orientation-selective (sos) neurons. we recorded 57 sos neurons from the caudal part of the lateral bank of the intraparietal sulcus (area cip) of three hemispheres of two ...200010805708
analysis of japanese monkeys (macaca fuscata) and dogs with naturally occurring japanese cedar (cryptomeria japonica) pollinosis.the natural occurrence of cj pollinosis has been found in japanese monkeys and dogs. these animals have reactivity to cj major allergens. monkeys and dogs can serve as a suitable animal model in the study of cj pollinosis.200010815234
analysis of japanese monkeys (macaca fuscata) and dogs with naturally occurring japanese cedar (cryptomeria japonica) pollinosis.the natural occurrence of cj pollinosis has been found in japanese monkeys and dogs. these animals have reactivity to cj major allergens. monkeys and dogs can serve as a suitable animal model in the study of cj pollinosis.200010815234
widespread gene transfection into the central nervous system of primates.we attempted in vivo gene transfection into the central nervous system (cns) of non-human primates using the hemagglutinating virus of japan (hvj)-ave liposome, a newly constructed anionic type liposome with a lipid composition similar to that of hiv envelopes and coated by the fusogenic envelope proteins of inactivated hvj. hvj-ave liposomes containing the lacz gene were applied intrathecally through the cisterna magna of japanese macaques. widespread transgene expression was observed mainly in ...200010822302
altered expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in acutely rejected myocardium and coronary arteriosclerosis in cardiac allografts of nonhuman primates.matrix metalloproteinases (mmps) and tissue inhibitors of metalloproteinases (timps) are important in any process of tissue remodeling. however, there is no report evaluating their expression in cardiac allografts in human or non-human primates. heterotopic cardiac transplantation was performed on japanese monkeys. subjects were treated with chimeric anti-human lymphocyte function-associated antigen-1 monoclonal antibody for 2 weeks. heart grafts were harvested at days 1-95 (n = 7). native monke ...200010836646
altered expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in acutely rejected myocardium and coronary arteriosclerosis in cardiac allografts of nonhuman primates.matrix metalloproteinases (mmps) and tissue inhibitors of metalloproteinases (timps) are important in any process of tissue remodeling. however, there is no report evaluating their expression in cardiac allografts in human or non-human primates. heterotopic cardiac transplantation was performed on japanese monkeys. subjects were treated with chimeric anti-human lymphocyte function-associated antigen-1 monoclonal antibody for 2 weeks. heart grafts were harvested at days 1-95 (n = 7). native monke ...200010836646
studies on karyotype evolution in higher primates in relation to human chromosome 14 and 9 by comparative mapping of immunoglobulin c epsilon genes with fluorescence in situ hybridization.karyotypic homologies in relation to human chromosome 14 and 9 were studied through comparative mapping of the immunoglobulin c epsilon genes in higher primates by fluorescence in situ hybridization (fish) technique. the c epsilon genes will be suitable probes for the analysis of evolutionary rearrangements due to that the multiple recombinational events such as gene duplications and deletions have occurred repeatedly in the immunoglobulin ch gene family (igh@) during the course of primate evolu ...199910859938
connections between the medial temporal cortex and the ca1 subfield of the hippocampal formation in the japanese monkey (macaca fuscata).the connections between the medial temporal cortical areas and ca1 of the hippocampus were examined in the japanese monkey (macaca fuscata) by means of retrograde and anterograde tract-tracing methods with wheat germ agglutinin-conjugated horseradish peroxidase (wga-hrp) and fluorescent dyes (fast blue and diamidino yellow). the posterior parahippocampal (areas tf1, tf2, and th), perirhinal (areas 35 and 36), and ventral inferotemporal areas (areas teav and tepv) were reciprocally connected with ...200010867659
species difference in enantioselectivity for the oxidation of propranolol by cytochrome p450 2d enzymes.we examined and compared enantioselectivity in the oxidation of propranolol (pl) by liver microsomes from humans and japanese monkeys (macaca fuscata). pl was oxidized at the naphthalene ring to 4-hydroxypropranolol, 5-hydroxypropranolol and side chain n-desisopropylpropranolol by human liver microsomes with enantioselectivity of [r(+)>s(-)] in pl oxidation rates at substrate concentrations of 10 microm and 1 mm. in contrast, reversed enantioselectivity [r(+)<s(-)] in pl 5-hydroxylation and n-de ...200010903420
species difference in enantioselectivity for the oxidation of propranolol by cytochrome p450 2d enzymes.we examined and compared enantioselectivity in the oxidation of propranolol (pl) by liver microsomes from humans and japanese monkeys (macaca fuscata). pl was oxidized at the naphthalene ring to 4-hydroxypropranolol, 5-hydroxypropranolol and side chain n-desisopropylpropranolol by human liver microsomes with enantioselectivity of [r(+)>s(-)] in pl oxidation rates at substrate concentrations of 10 microm and 1 mm. in contrast, reversed enantioselectivity [r(+)<s(-)] in pl 5-hydroxylation and n-de ...200010903420
incidence of listeria monocytogenes in wild animals in japan.between 1991 and 1993, the intestinal contents and feces of wild animals in japan were examined for the presence of listeria. the wild animals examined included 623 mammals (11 species) and 996 birds (18 species). listeria species were isolated from 38 (6.1%) of the 623 mammalian samples and 133 (13.4%) of 996 bird samples. the highest incidence of listeria in the mammals was found in japanese monkeys (20.0%) and that in birds was found in crows (43.2%). the incidence of listeria in japanese mon ...200010907701
incidence of listeria monocytogenes in wild animals in japan.between 1991 and 1993, the intestinal contents and feces of wild animals in japan were examined for the presence of listeria. the wild animals examined included 623 mammals (11 species) and 996 birds (18 species). listeria species were isolated from 38 (6.1%) of the 623 mammalian samples and 133 (13.4%) of 996 bird samples. the highest incidence of listeria in the mammals was found in japanese monkeys (20.0%) and that in birds was found in crows (43.2%). the incidence of listeria in japanese mon ...200010907701
factors influencing the salience of temporal cues in the discrimination of synthetic japanese monkey (macaca fuscata) coo calls.if temporal position of a frequency inflection is the most salient communication cue in japanese macaque smooth early and smooth late high coos, then macaques should perceive coos differing only along the early-late dimension as belonging to different classes. the perceived similarity of synthetic coos and temporally reversed variants were evaluated, using multidimensional scaling of macaque discrimination latencies. original calls and calls temporally reversed in the frequency domain could be d ...200010913991
interference from irrelevant features on visual discrimination by macaques (macaca fuscata): a behavioral analogue of the human stroop effect.to study the operation of selective attention in a conflict situation with automatic processes, we trained 4 japanese macaques (macaca fuscata) extensively on a manual go/no-go task. the monkey had to discriminate either the color, shape, motion direction, or location of a visual stimulus. in each trial, the behavioral meaning of the relevant feature (go or no-go) could either be congruent or incongruent with irrelevant features of the same stimulus. reaction times were slowed, and error rates i ...200010913998
structural variations of the vwa locus in humans and comparison with non-human primates.the humvwa locus was examined in 160 samples from the japanese population. a total of 142 fragments were sequenced, and the counterpart sequences were also determined in non-human primates. in humans, 10 different alleles were found; they could be grouped into seven allelic classes based on the total number of repeats. no variation was observed in the alleles 17, 18 and 19, which showed consensus sequence structures and in the allele 14, which showed a different structure. new variation was foun ...200010978593
evolution of the abo blood group gene in japanese macaque.we determined 5 sequences of japanese macaque abo blood group gene exon 7 (ca. 0.5 kb) and 2 sequences for exon 5 and intron 6 (ca. 1.7 kb). we compared those data with published sequences of other old world monkey species, and the results suggest that alleles a and b were polymorphic in the ancestral species of macaques, and that b type allele evolved independently in macaque and baboon lineages.200010984838
the effect of disparity on the very earliest ocular following responses and the initial neuronal activity in monkey cortical area mst.movement of the visual scene evokes tracking movement with the eyes (ocular following response, ofr) at short latency (miles, f.a., kawano, k., optican, l.m., 1986. short-latency ocular following responses of monkey. i. dependence on temporospatial properties of visual input. j. neurophysiol. 56, 1321-1354). we examined the effect of binocular disparity on the initial ofr. the dependence of the ofr on horizontal disparity steps was studied in three monkeys (macaca fuscata), and the associated un ...200010997582
bilateral receptive field neurons in the hindlimb region of the postcentral somatosensory cortex in awake macaque monkeys.single-neuron activities were recorded in the hindlimb region of the primary somatosensory cortex and part of area 5 in awake japanese monkeys. a total of 1050 units were isolated from five hemispheres of four animals. receptive fields (rfs) and submodalities were identified for 90% of isolated neurons in areas 3a and 3b. the percentage decreased as the recoding site moved to the more caudal areas. deep or skin submodality neurons were dominant in area 3a or area 3b, respectively. deep submodali ...200011037280
bilateral receptive field neurons in the hindlimb region of the postcentral somatosensory cortex in awake macaque monkeys.single-neuron activities were recorded in the hindlimb region of the primary somatosensory cortex and part of area 5 in awake japanese monkeys. a total of 1050 units were isolated from five hemispheres of four animals. receptive fields (rfs) and submodalities were identified for 90% of isolated neurons in areas 3a and 3b. the percentage decreased as the recoding site moved to the more caudal areas. deep or skin submodality neurons were dominant in area 3a or area 3b, respectively. deep submodali ...200011037280
topographic effects on spatial data at a japanese macaque study site.in mountainous topography, actual travel distances and home range areas are larger than those measured on a flat map. this paper analyzed the increase in spatial measures that occurred when topography was taken into account for data collected at a mountainous study site of the japanese macaque. both travel distances and home range areas increased when measured on a computerized terrain model compared to those measured on a flat map. the travel distance changes varied among troops as well as indi ...200011078028
species-specific tt viruses in humans and nonhuman primates and their phylogenetic relatedness.by means of polymerase chain reaction with a primer pair (ng133-ng147) deduced from the untranslated region (utr) of tt virus (ttv), ttvs with markedly distinct genomic lengths were recovered from sera of humans and nonhuman primates, and their entire nucleotide sequences were determined. a human ttv [tgp96 of 2908 nucleotides (nt)] was obtained that was about 900 nt shorter than heretofore reported ttvs (3787-3853 nt). likewise, ttvs of chimpanzee occurred in two distinct genomic sizes [pt-ttv6 ...200011080484
gene therapy for attenuating cardiac allograft arteriopathy using ex vivo e2f decoy transfection by hvj-ave-liposome method in mice and nonhuman primates.cardiac allograft arteriopathy, which limits the long-term survival of recipients, is characterized by diffuse intimal thickening composed of proliferative smooth muscle cells. the transcription factor e2f plays a pivotal role in the coordinated transcription of cell-cycle regulatory genes. to test the hypothesis that double-stranded dna with specific affinity for e2f (e2f decoy) is effective in preventing intimal hyperplasia, we performed ex vivo single intraluminal delivery of e2f decoy into c ...200011090553
gene therapy for attenuating cardiac allograft arteriopathy using ex vivo e2f decoy transfection by hvj-ave-liposome method in mice and nonhuman primates.cardiac allograft arteriopathy, which limits the long-term survival of recipients, is characterized by diffuse intimal thickening composed of proliferative smooth muscle cells. the transcription factor e2f plays a pivotal role in the coordinated transcription of cell-cycle regulatory genes. to test the hypothesis that double-stranded dna with specific affinity for e2f (e2f decoy) is effective in preventing intimal hyperplasia, we performed ex vivo single intraluminal delivery of e2f decoy into c ...200011090553
acquisition and development of monkey tool-use: behavioral and kinematic analyses.four japanese macaques were trained in the use of a t-shaped rake. use the tool and development of the level of the skill of tool-use took place in three distinct stages. during stage 1, two of the monkeys seemed to use insight for initial solution, while fortuitous experiences led the other two monkeys to the solution. all the monkeys used the tool in a stereotyped manner and could retrieve food only when the tool was placed close to the food. at stage 2 the monkeys became able to manipulate th ...200011100944
biomechanical analysis of vertical climbing in the spider monkey and the japanese macaque.climbing is one of the most important components of primate locomotor modes. we previously reported that the kinesiological characteristics of vertical climbing by the spider monkey and japanese macaque are clearly different, based on their kinetics and kinematics. in this study, a more detailed analysis using inverse dynamics was conducted to estimate the biomechanical characteristics of vertical climbing in the spider monkey and japanese macaque. one of the main findings was the difference in ...200011102881
expression of membrane-type 1 matrix metalloproteinase in coronary vessels of allotransplanted primate hearts.the mechanisms of intimal thickening in cardiac allograft vasculopathy (cav) remain controversial after heart transplantation. matrix metalloproteinase-2 (mmp-2) plays a crucial role in degrading extracellular matrix (ecm) during neointimal formation. recently, it has been revealed that mmp-2 is activated by membrane-type 1 matrix metalloproteinase (mt1-mmp). this process involves tissue inhibitor of mmp-2 (timp-2), forming an mt1-mmp/timp-2/pro-mmp-2 complex. in this study, we hypothesize that ...200011124489
expression of membrane-type 1 matrix metalloproteinase in coronary vessels of allotransplanted primate hearts.the mechanisms of intimal thickening in cardiac allograft vasculopathy (cav) remain controversial after heart transplantation. matrix metalloproteinase-2 (mmp-2) plays a crucial role in degrading extracellular matrix (ecm) during neointimal formation. recently, it has been revealed that mmp-2 is activated by membrane-type 1 matrix metalloproteinase (mt1-mmp). this process involves tissue inhibitor of mmp-2 (timp-2), forming an mt1-mmp/timp-2/pro-mmp-2 complex. in this study, we hypothesize that ...200011124489
status of japanese monkeys under debate. 200011130045
status of japanese monkeys under debate. 200011130045
japanese monkeys perceive sensory consonance of chords.consonance/dissonance affects human perception of chords from early stages of development [e.g., schellenberg and trainor, j. acoust. soc. am. 100, 3321-3328 (1996)]. to examine whether consonance has some role in audition of nonhumans, three japanese monkeys (macaca fuscata) were trained to discriminate simultaneous two-tone complexes (chords). the task was serial discrimination (ax procedure) with repetitive presentation of background stimuli. each tone in a chord was comprised of six harmonic ...200011144600
japanese monkeys perceive sensory consonance of chords.consonance/dissonance affects human perception of chords from early stages of development [e.g., schellenberg and trainor, j. acoust. soc. am. 100, 3321-3328 (1996)]. to examine whether consonance has some role in audition of nonhumans, three japanese monkeys (macaca fuscata) were trained to discriminate simultaneous two-tone complexes (chords). the task was serial discrimination (ax procedure) with repetitive presentation of background stimuli. each tone in a chord was comprised of six harmonic ...200011144600
efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the japanese monkey, macaca fuscata.the infralimbic area (il) and prelimbic area (pl) have been postulated as an autonomic motor region in the medial prefrontal cortex. the present study was conducted to reveal the projection sites of il and pl of the monkey, macaca fuscata, using biotinylated dextran amine as an anterograde tracer. il and pl projected densely to the ventromedial caudate nucleus, the core and shell of the nucleus accumbens (acb), parvicellular lateral basal and magnocellular accessory basal nuclei of the amygdala, ...200111146055
changes in the retinotopical fiber order along the horizontal and dorsoventral axes of the nasal retina in the monkey optic chiasm.the fiber arrangement of the retinogeniculate pathways was investigated in the japanese monkey chiasm by iontophoretical injections into the lateral geniculate nucleus of wheat germ agglutinin conjugated to horseradish peroxidase. the present data demonstrated that the horizontal and dorsoventral axes of the nasal retina were rearranged in gross dorsoventral and posteroanterior orders in the chiasm. thus, foveal/parafoveal fibers passed across the dorsal chiasm in a cluster and midperipheral nas ...200011151450
reconstruction of the primate mandible with a combination graft of recombinant human bone morphogenetic protein-2 and bone marrow.this study evaluated whether recombinant human bone morphogenetic protein-2 (rhbmp-2) can be used to regenerate a resected part of the mandible in a primate model.200111152190
reconstruction of the primate mandible with a combination graft of recombinant human bone morphogenetic protein-2 and bone marrow.this study evaluated whether recombinant human bone morphogenetic protein-2 (rhbmp-2) can be used to regenerate a resected part of the mandible in a primate model.200111152190
spatial distribution of cingulate cells projecting to the primary, supplementary, and pre-supplementary motor areas: a retrograde multiple labeling study in the macaque monkey.we examined the location and spatial distribution of cingulate cortical cells projecting to the forelimb areas of the primary motor cortex (mi), supplementary motor area (sma), and pre-supplementary motor area (pre-sma) using a multiple retrograde labeling technique in the monkeys (macaca fuscata). the forelimb areas of the mi, sma and pre-sma were physiologically identified, based on the findings of intracortical microstimulation (icms) and single cell recording. three different tracers, diamid ...200111164252
cytoarchitectonic subdivisions of the parabrachial nucleus in the japanese monkey (macacus fuscatus) with special reference to spinoparabrachial fiber terminals.the cytoarchitectonic subnuclear organization of the parabrachial nucleus (pb) surrounding the brachium conjunctivum (bc) in the monkey was examined using the nissl method and the anterograde axonal flow method. pb of the monkey could be divided into the following subnuclei: the dorsal area (dpbm) along the medial surface of the medial three-fourths of bc in the caudal half of medial pb (pbm), the ventral area (vpbm) along the medial surface of the lateral one-fourth of bc in the rostral two-thi ...200111164257
a case of pulmonary acariasis in lung of japanese macaque.a 20-year-old female japanese macaque, weighing 8.7 kg, developed severe pulmonary acariasis. numerous whitish nodules, 2-4 mm, were scattered throughout the lungs. histologically multifocal granulomatous lesions consisting of a large number of eosinophils, epithelioid cells, foreign body type giant cells, and collagen fibers were aggregated around the mait bodies. numerous mast cells were also detected in the lesions by toluidine blue staining, and tested positive for tryptase by immunohistoche ...200111217071
axon trajectories in local circuits of the primary motor cortex in the macaque monkey (macaca fuscata).the intrinsic trajectories and terminal arbors of two axons and one horizontal axon collateral within the primary motor cortex (m1) were studied in the macaque monkey using injections of biotinylated dextran amine (bda) into the putative primary forelimb motor cortex, and two-dimensional (2-d) reconstruction of the individually labeled axons and collateral. (1) a long collateral of the main axon from a large pyramidal cell in layer vb of the putative forelimb area on the anterior bank of the cen ...200111223469
visually based path-planning by japanese monkeys.to construct an animal model of strategy formation, we designed a maze path-finding task. first, we asked monkeys to capture a goal in the maze by moving a cursor on the screen. cursor movement was linked to movements of each wrist. when the animals learned the association between cursor movement and wrist movement, we established a start and a goal in the maze, and asked them to find a path between them. we found that the animals took the shortest pathway, rather than approaching the goal rando ...200111240119
visually based path-planning by japanese monkeys.to construct an animal model of strategy formation, we designed a maze path-finding task. first, we asked monkeys to capture a goal in the maze by moving a cursor on the screen. cursor movement was linked to movements of each wrist. when the animals learned the association between cursor movement and wrist movement, we established a start and a goal in the maze, and asked them to find a path between them. we found that the animals took the shortest pathway, rather than approaching the goal rando ...200111240119
two possible mechanisms underlying nitrate tolerance in monkey coronary arteries.1. previous studies using isolated arteries have demonstrated cross-tolerance between nitric oxide (no) donors such as nitroglycerin (ntg) and sodium nitroprusside (snp). however, it remains unclear whether the vasorelaxing effect of atrial natriuretic peptide (anp), an activator of particulate guanylate cyclase, is affected by treatment with no donors. to investigate the cross-tolerance and interactions between ntg and anp in coronary vasorelaxant responses, we used two models of monkey coronar ...200111251637
high-performance liquid chromatographic analysis of the sulfation of 4-hydroxypropranolol enantiomers by monkey liver cytosol.we developed a new high-performance liquid chromatographic method using an ods column and a chiral column for the assay of racemic 4-oh-pl sulfate and enantiomeric 4-oh-pl sulfates, respectively. the method was successfully applied to measure phenolsulfotransferase (pst) activities for 4-oh-pl in cytosolic fractions from livers of japanese monkeys (macaca fuscata) and for comparison with its activity of cytosolic fractions from rat, rabbit, dog, and human livers and hep g2 cells. the activity wa ...200111270323
high-performance liquid chromatographic analysis of the sulfation of 4-hydroxypropranolol enantiomers by monkey liver cytosol.we developed a new high-performance liquid chromatographic method using an ods column and a chiral column for the assay of racemic 4-oh-pl sulfate and enantiomeric 4-oh-pl sulfates, respectively. the method was successfully applied to measure phenolsulfotransferase (pst) activities for 4-oh-pl in cytosolic fractions from livers of japanese monkeys (macaca fuscata) and for comparison with its activity of cytosolic fractions from rat, rabbit, dog, and human livers and hep g2 cells. the activity wa ...200111270323
measurement of urinary and fecal steroid metabolites during the ovarian cycle in captive and wild japanese macaques, macaca fuscata.we measured the concentration of steroid hormones from urine, feces, and blood samples of two captive japanese macaques, macaca fuscata, during nonconceptive ovarian cycles to compare the patterns of the excreted steroids with those of circulating steroids. urine and feces were analyzed for estrone conjugates (e1c) and pregnanediol-3-glucronide (pdg) using enzyme immunoassays (eias), while plasma was analyzed for estradiol-17beta(e2), progesterone (p), and luteinizing hormone (lh) using radioimm ...200111283977
somatotopic arrangement and corticocortical inputs of the hindlimb region of the primary motor cortex in the macaque monkey.using japanese monkeys, we examined the somatotopic organization of the hindlimb region of the primary motor cortex (mi) with intracortical microstimulation. in the hindlimb region of the mi, areas representing distal movements (digits and ankle joints) were basically surrounded by those representing proximal movements (knee and hip joints). thus, the hindlimb region of the mi has a nested or horseshoe-like somatotopic representation. we then examined the topographic organization of corticocorti ...200111311401
somatotopic arrangement and corticocortical inputs of the hindlimb region of the primary motor cortex in the macaque monkey.using japanese monkeys, we examined the somatotopic organization of the hindlimb region of the primary motor cortex (mi) with intracortical microstimulation. in the hindlimb region of the mi, areas representing distal movements (digits and ankle joints) were basically surrounded by those representing proximal movements (knee and hip joints). thus, the hindlimb region of the mi has a nested or horseshoe-like somatotopic representation. we then examined the topographic organization of corticocorti ...200111311401
[experimental study of secondary bone graft of alveolar clefts using bone morphogenetic protein (bmp)].the purpose of this study was to evaluate the utility of recombinant human bone morphogenetic protein-2 (rhbmp-2) as a bone substitute on artificial alveolar clefts of adult macaca fuscata monkeys. first, we created simulated alveolar clefts to represent human bilateral alveolar clefts, and then we implanted a mixture of rhbmp-2 and autogeneous particulate marrow cancellous bone (pmcb) into these models, as experimental groups. the mixture ratio was varied as follows (mixture ratio = rhbmp-2: pm ...200111321800
an investigation of sensory deficits underlying the aphasia-like behavior of macaques with auditory cortex lesions.bilateral auditory cortex lesions in japanese macaques result in an aphasia-like deficit in which the animals are unable to discriminate two forms of their coo vocalizations. to determine whether this deficit is sensory in nature, two monkeys with bilateral lesions were tested for their ability to discriminate frequency and frequency change. the results indicated that although the animals were able to discriminate between sounds of different frequencies, they were unable to determine whether a s ...200111338194
object discrimination learning in aged japanese monkeys.the authors investigated the behavioral aging effects of japanese macaques in 3 object discrimination learning tasks: learning-set (ls) formation, go/no-go discrimination learning, and multiple discrimination reversals. aged monkeys showed deteriorated performance in these tasks compared with younger controls. hypothesis analysis of ls showed that aged monkeys had difficulty learning the lose-shift component of the hypothesis win-stay-lose-shift with respect to object. deficits in go/no-go succe ...200111345953
object discrimination learning in aged japanese monkeys.the authors investigated the behavioral aging effects of japanese macaques in 3 object discrimination learning tasks: learning-set (ls) formation, go/no-go discrimination learning, and multiple discrimination reversals. aged monkeys showed deteriorated performance in these tasks compared with younger controls. hypothesis analysis of ls showed that aged monkeys had difficulty learning the lose-shift component of the hypothesis win-stay-lose-shift with respect to object. deficits in go/no-go succe ...200111345953
relative pitch perception in japanese monkeys (macaca fuscata).to investigate whether monkeys perceive relative pitch, the author trained 3 japanese monkeys (macaca fuscata) to detect changes from rising to falling contours of 3-tone sequences. tone sequences were presented serially with transposition, so monkeys were urged to attend to cues other than the absolute frequency of a component tone. results from probe tests with novel sequences showed that monkeys discriminated by the relative pitch when the frequency ranges of sequences were within the trainin ...200111459159
relative pitch perception in japanese monkeys (macaca fuscata).to investigate whether monkeys perceive relative pitch, the author trained 3 japanese monkeys (macaca fuscata) to detect changes from rising to falling contours of 3-tone sequences. tone sequences were presented serially with transposition, so monkeys were urged to attend to cues other than the absolute frequency of a component tone. results from probe tests with novel sequences showed that monkeys discriminated by the relative pitch when the frequency ranges of sequences were within the trainin ...200111459159
seasonal changes of humoral and cellular immune responses to japanese cedar (cryptomeria japonica) pollen allergens in japanese monkeys (macaca fuscata) with pollinosis.the natural occurrence of japanese cedar [cryptomeria japonica (cj)] pollinosis has been reported in japanese monkeys (macaca fuscata). the present study was designed to investigate seasonal changes in immunological reactions to cj pollen allergens in monkeys with cj pollinosis. blood samples were collected from six monkeys with cj pollinosis before and after cj pollen season. seasonal changes in specific ige and igg to major allergens (cry j 1 and cry j 2) were observed before and after cj poll ...200111491404
seasonal changes of humoral and cellular immune responses to japanese cedar (cryptomeria japonica) pollen allergens in japanese monkeys (macaca fuscata) with pollinosis.the natural occurrence of japanese cedar [cryptomeria japonica (cj)] pollinosis has been reported in japanese monkeys (macaca fuscata). the present study was designed to investigate seasonal changes in immunological reactions to cj pollen allergens in monkeys with cj pollinosis. blood samples were collected from six monkeys with cj pollinosis before and after cj pollen season. seasonal changes in specific ige and igg to major allergens (cry j 1 and cry j 2) were observed before and after cj poll ...200111491404
age changes in plasma igf-1 concentration in free-ranging japanese macaques (macaca fuscata).to obtain fundamental data on the endocrine background for the wild japanese macaque (macaca fuscata) growth profiles, we have measured plasma insulin-like growth factor 1 (igf-1) concentrations of free-ranging and open-enclosed japanese macaques from five different regions in their habitat. general features of the igf-1 levels in those troops were: 1) an age-dependent increase in the young macaques and 2) distinctively higher values among several adult females. the age changes in igf-1 levels d ...200111515673
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