Publications

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[morphological, biological and physiological studies of trichophyton rubrum. ii. studies on amino acid assimilation and vitamin requirements]. 196213919071
microscopic morphology of trichophyton rubrum. 196113919606
[on the differential diagnosis of trichophyton mentagrophytes and trichophyton rubrum]. 196213960322
[unapparent skin disease due to trichophyton rubrum manifested by furunculosis]. 196313971098
black dot tinea capitis caused by trichophyton rubrum. 196313986152
[infection by trichophyton rubrum and cushing's syndrome]. 196214013868
differentiation of trichophyton rubrum from trichophyton mentagrophytes. 196314057957
[dermatophytosis caused by trichophyton rubrum]. 196314077670
[on the clinical polymorphism achieved by trichophyton rubrum]. 196314078771
[on difficulties in differentiating between trichophyton mentagrophytes and trichophyton rubrum]. 196314121849
the fatty acids of trichophyton rubrum. 196414124857
immune responses to trichophyton rubrum infections. 196314148786
onychomycosis of the right thumbnail, due to microsporum lanosum. dermatophytosis of the feet with onychomycosis. (causative organism undetermined, probably trichophyton rubrum). 196414149734
[on the dermatophytes in the essen area 1962/63 with special reference to the methods for delimitation of trichophyton rubrum from trichophyton mentagrophytes]. 196414191299
studies on hyperpigmented form of trichophyton rubrum. 196414240696
trichophyton rubrum infection resistant to griseofulvin. 196414240697
enzyme make-up of trichophyton rubrum and t. mentagrophytes. ii. amylase activity. 196414257101
[predisposition to infection by trichophyton rubrum: biochemical and functional studies]. 196414257111
[on familial trichophyton rubrum infection]. 196514265080
[on the treatment of trichophyton rubrum infections with itsenko-cushing's syndrome with griseofulvin]. 196514287681
[growth differences between trichophyton rubrum and trichophyton mentagrophytes on nail keratin in vitro]. 196414291440
the treatment of trichophyton rubrum infections of the toenails and feet with a new ultrafine form of griseofulvin. 196514323110
differentiation of trichophyton rubrum and trichophyton mentagrophytes by pigment production. 196514325898
[the mode of infection of hair by trichophyton mentagrophytes and trichophyton rubrum in vitro]. 196514326806
tinea barbae caused by trichophyton rubrum. 195514360797
[chamber shoe disinfection in epidermophytosis and trichophyton rubrum infection]. 196014404362
treatment of cutaneous trichophyton rubrum infection with human immune globulin. 196014417201
trichophyton rubrum: exposure and infection within household groups. 196014420791
recurrent cushing's syndrome with trichophyton rubrum infection. 195914426466
the isolation of strains of trichophyton rubrum which produce a melanin-like substance in culture media. 196114457365
[in vitro studies on the effect of selected antifungal preparations on epidermophyton kaufmann-wolf-priestley and epidermophyton rubrum castellani]. 196114479794
epidemiology, clinical presentation and diagnosis of onychomycosis.onychomycosis is a common nail disease, responsible for up to 50% of diseases of the nail. the distribution of different pathogens is not uniform; it depends on various factors such as climate, geography and migration. however, studies have revealed that two dermatophytes, trichophyton rubrum and trichophyton mentagrophytes, account for more than 90% of onychomycoses. onychomycosis can be divided into four major clinical presentations: distal subungal (the most common form of the disease), proxi ...200314510968
two hundred ninety-six cases of onychomycosis in children and teenagers: a 10-year laboratory survey.there is still little data available about the epidemiology of childhood onychomycosis. looking at our laboratory figures over a 10-year period provided us with some useful information. nail keratin samples were taken by dermatologists from 21,557 patients with nail conditions, mainly in the brussels region. the specimens were examined by direct microscopy and/or histology, and cultured on sabouraud medium agar. only patients less than 17 years of age were considered as children. clinical inform ...200314521552
constituents of the argentinian medicinal plant baccharis grisebachii and their antimicrobial activity.the resinous exudate of baccharis grisebachii which is used to treat ulcers, burns, and skin sores in argentina showed activity towards dermatophytes and bacteria. two diterpenes, eight p-coumaric acid derivatives, and two flavones were isolated from the exudate and the structures elucidated by spectroscopic methods. 3-prenyl-p-coumaric acid and 3,5-diprenyl-p-coumaric acid were active towards epidermophyton floccosum and trichophyton rubrum with mics of 50 and 100-125 microg/ml, respectively. t ...200314522435
ciclopirox gel in the treatment of patients with interdigital tinea pedis.background tinea pedis (athlete's foot) is the most common fungal infection in the general population. ciclopirox, a broad-spectrum hydroxypyridone antifungal, has proven efficacy against the organisms commonly implicated in tinea pedis; trichophyton rubrum, t.mentagrophytes and epidermophyton floccosum.200314567368
[epidemiological survey of dermatophytosis in spain (april-june 2001)].a three-month (april-june 2001) cross-sectional study was designed to assess the epidemiological profile of dermatophytosis in spain.200314572379
in vitro analysis of the ability of trichophyton rubrum to become resistant to terbinafine.in this study, we have investigated in vitro the resistance frequency and development of resistance to terbinafine of trichophyton rubrum. results demonstrated that naturally occurring mutants are rare and that t. rubrum appears to have little capacity to develop resistance to terbinafine even after prolonged exposure.200314576134
deep infection by trichophyton rubrum in an immunocompromised patient.dermatophytes are common pathogens of skin but rarely cause invasive disease. we present a case of deep infection by trichophyton rubrum in an immunocompromised patient. t. rubrum was identified by morphological characteristics and confirmed by pcr. invasiveness was apparent by histopathology and immunohistochemistry. the patient was treated successfully with itraconazole.200314605189
epidemiology of dermatophyte infection in auckland, new zealand.this report describes the epidemiology of culture-proven dermatophyte infection in auckland, new zealand. the authors undertook a retrospective review of laboratory data for the period from june 1999 to july 2002. there were 10 004 dermatophyte isolates. the most common isolates were trichophyton rubrum (69%) and trichophyton mentagrophytes (19%). microsporum canis was mainly isolated from children. the prevalence of t. mentagrophytes increased with patient age (p < 0.001). trichophyton rubrum w ...200314616492
evaluation of in vitro resistance in patients with onychomycosis who fail antifungal therapy.with the increased awareness of onychomycosis and the increasing use of antifungals for this indication, it is prudent to be concerned about the possible emergence of resistant strains. there has been substantial work on the development of standardized methods for testing the in vitro resistance of various fungi and yeasts to the currently available antifungal agents. however, relatively little research has been published concerning the resistance of dermatophyte species.200314657630
derivatives of phosphate schiff base transition metal complexes: synthesis, studies and biological activity.we report the synthesis and structural characterization of series of tetra- and hexacoordinate metal chelate complexes of phosphate schiff base ligands having the general composition lmx(n).h(2)o and l(2)mx(n) (l=phosphate schiff base ligand; m=ag(+), mn(2+), cu(2+), zn(2+), cd(2+), hg(2+), or fe(3+) and x=no(3)(-), br(-) or cl(-)). the structure of the prepared compounds was investigated using elemental analysis, ir, 1h and 31p nmr, uv-vis, mass spectra, solid reflectance, magnetic susceptibili ...200414670488
epidemiology of dermatophytoses in an area south of tehran, iran.dermatophyte infections have been considered to be a major public health problem in many parts of the world. the aim of this study was to identify the etiological and epidemiological factors of dermatophyte infections in an area south of tehran. a total of 1254 patients suspected to have dermatophytic lesions were examined over a period of three years (1999-2001). material collected from skin, hair, and nails was submitted to direct microscopic examination using koh, cultured in sabouraud dextro ...200314682452
clinical characteristics and mycology of onychomycosis in autoimmune patients.onychomycosis is the most common nail disorder in adults. predisposing factors are immunosuppression, poor peripheral circulation, diabetes mellitus, increasing age, nail trauma, and tinea pedis. autoimmune patients, who carry many of these predisposing factors, have never been studied. autoimmune patients, with underlying autoimmune skin diseases; pemphigus, systemic lupus erythematosus (sle), mixed connective tissue disease (mctd), scleroderma, dermatomyositis and cutaneous vasculitis, as well ...200314696780
itraconazole pulse therapy in the treatment of disto-lateral subungual onychomycosis.to assess the efficacy of itraconazole pulse therapy in disto-lateral subungual onychomycosis.200314700485
prevalence of foot diseases in outpatients attending the institute of dermatology, bangkok, thailand.two thousand patients who visited the outpatient department at the institute of dermatology, bangkok, were assessed for the presence of foot diseases by questionnaire and physical examination. abnormalities were detected in 741 individuals (37.1%). nonfungal conditions were more prevalent (31.4%), mainly consisting of eczema (254 cases, 12.7%) and psoriasis (176 cases, 8.8%). fungal disease was observed in 119 cases (6.0%). there were 76 cases (3.8%) with tinea pedis and 33 cases (1.7%) with ony ...200414723731
tinea barbae (tinea sycosis): experience with nine cases.tinea barbae is a rare dermatophytosis that affects the hair and hair follicles of the beard and mustache. this paper presents 9 cases of tinea barbae observed over an 18-year period of time and classified as follows: 1 was superficial and 8 were deep (6 folliculitis-like and 2 kerion-like). most of the cases (4) were associated with topical steroid therapy, others with pet contact (3 cases) and one with diabetes. the causal agents isolated were: trichophyton rubrum in 3; microsporum canis in 3; ...200314739517
[clinical types of onychomycosis].clinical classification of onychomycosis is based on how the pathogenic agent penetrates the unguis. the disto-lateral sub-ungual variety is the most common. dermatophytes (especially trichophyton rubrum) and scytalidium in tropical regions (sc hyalium, sc dimidiatum) are the most frequent toenail pathogens. progression of a yellow friable sub-ungual hyperkeratosis associated with longitudinal striations and/or xanthonychial or leuconychial zones (sometimes pigmented with trichophyton rubrum nig ...200314743110
dermatophyte agents in the city of são paulo, from 1992 to 2002.dermatophytosis are superficial mycoses caused by fungi that can invade stratum corneum and keratinized tissues. in order to study the frequency of dermatophytes species and the clinical manifestations caused by these fungi, in são paulo, sp, brazil, the authors analyzed cultures isolated at the mycology laboratory from a selected population (15,300 out-patients of the hospital das clínicas, department of dermatology, faculty of medicine of university of são paulo) from january 1992 to june 2002 ...200314743665
pcr and pcr-rflp techniques targeting the dna topoisomerase ii gene for rapid clinical diagnosis of the etiologic agent of dermatophytosis.we have focused on the dna topoisomerase ii genes of several pathogenic fungi, and developed polymerase chain reaction (pcr) and pcr-restriction fragment length polymorphism (rflp) methods targeting this gene for identification of dermatophytes.200414757280
antimicrobial activity of hyptis ovalifolia towards dermatophytes.the essential oil and the aqueous, hexane and methanolic fractions from hyptis ovalifolia leaves were evaluated for their antifungal activity in vitro against 60 strains of dermatophytes: 10 strains of microsporum canis, 10 of m. gypseum, 20 of trichophyton rubrum and 20 of t. mentagrophytes. the extracts inhibited growth of the dermatophytes tested at different concentrations. the most biologically active was the essential oil from the leaves which inhibited 57 isolates (95%) at a concentration ...200414762526
multiplication of an ancestral gene encoding secreted fungalysin preceded species differentiation in the dermatophytes trichophyton and microsporum.dermatophytes are human and animal pathogenic fungi which cause cutaneous infections and grow exclusively in the stratum corneum, nails and hair. in a culture medium containing soy proteins as sole nitrogen source a substantial proteolytic activity was secreted by trichophyton rubrum, trichophyton mentagrophytes and microsporum canis. this proteolytic activity was 55-75 % inhibited by o-phenanthroline, attesting that metalloproteases were secreted by all three species. using a consensus probe co ...200414766908
[sycosis of the beard caused by trichophyton rubrum (castellani) sabouraud]. 195114822634
trichophyton rubrum tinea capitis in a young child.while the primary etiologic agent of tinea capitis in the united states has varied over the past century, the last several decades have been marked by a predominance of infection with trichophyton tonsurans. related anthropophilic organisms commonly isolated in other dermatophytoses are infrequently observed in tinea capitis. we report the unusual occurrence of tinea capitis in a young boy infected with trichophyton rubrum.200414871330
trichophytic granuloma (tinea profunda) due to trichophyton rubrum. 195214893975
[ringworm caused by trichophyton rubrum in algerian medical practice]. 195114934318
cicatrizing tinea capitis caused by trichophyton rubrum (trichophyton purpureum. 195214952024
in vitro antifungal activity of sertaconazole against 309 dermatophyte clinical isolates.three hundred and nine strains belonging to 11 species of dermatophyte moulds were tested against sertaconazole following mainly the national committee for clinical laboratory standards (m38-p) for filamentous fungi. however, several important factors such as the temperature (28 degrees c vs 35 degrees c) and time of incubation (4-10 d vs 21-74 h), have been modified. sertaconazole was active against all the clinically important dermatophyte moulds involved in human infections tested. overall ge ...200314998079
toenail onychomycosis in estonia.the aim of our study was to evaluate the clinical features, predisposing factors and pathogens of toenail onychomycosis in estonia. during study period we interviewed and examined 436 dermatological patients with clinical signs of toenail onychomycosis in all counties of estonia. in 69% of cases, the clinical diagnosis of onychomycosis was confirmed by the mycological analysis. the most common clinical symptoms of onychomycosis both in mycologically proven and non-proven cases were discolorizati ...200414998401
trichophyton rubrum in the external auditory meatus.we report the case of a 28-year-old immunocompetent male suffering from otitis externa. the right external auditory meatus was filled with cerumen and detritus, the tympanic membrane covered wallpaper-like with layers of fungi. mycological analysis revealed trichophyton rubrum. with further examination tinea pedis of plantar and interdigital type and concomitant onychomycosis of the toenails due to t. rubrum could be detected. the auditory meatus was cleaned and treated topically with clotrimazo ...200414998407
antidermatophytic activity of extracts from psoralea corylifolia (fabaceae) correlated with the presence of a flavonoid compound.extracts obtained from seeds of psoralea corylifolia showed several degrees of antifungal activity against trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum and microsporum gypseum by the disc diffusion method on a sabouraud dextrose agar (sda) medium. methanol extract of the seeds at 250 microg exhibited the maximum inhibition with a halo of 28 mm diameter. six different bands were obtained when the methanol extract was subjected to tlc. 13c nmr and mass spectra reveale ...200415036462
antibacterial and antifungal activity of syzygium jambolanum seeds.the water and methanolic extracts of syzygium jambolanum seeds were examined for antibacterial and antifungal activity in vitro using the disc diffusion method, minimum inhibitory concentration, minimum bactericidal concentration and minimum fungicidal concentration. activity against gram positive bacteria (bacillus subtilis, staphylococcus aureus), gram negative bacteria (salmonella typhimurium, pseudomonas aeruginosa, klebsiella pneumoniae and escherichia coli) and fungal strains (candida albi ...200415036477
[tinea capitis in children from goiânia, brazil].during the period january 1999 to july 2002 a total de 164 cases of tinea capitis were diagnosed by mycological examination in instituto de patologia tropical e saúde pública of the universidade federal de goiás. of the 164 patients 94 (57.3%) were males, with an age of 3 months to 13 years. laboratory studies were performed by direct examination with 20% koh and cultivated on mycobiotic agar medium and sabouraud dextrose agar with chloramphenicol. the following species were identified: microspo ...200315049102
the influence of surface carbohydrates during in vitro infection of mammalian cells by the dermatophyte trichophyton rubrum.in order to better understand the role played by surface glycoconjugates during host cell adhesion and endocytosis of trichophyton rubrum, we looked for the presence of carbohydrate-binding adhesins on the microconidia surface and their role on cellular interaction with epithelial and macrophages cells. the interaction of t. rubrum with chinese hamster ovary epithelial cells and their glycosylation-deficient mutants demonstrated a higher adhesion index in lec1 and lec2 mutants, that express mann ...200415059626
pharmacokinetic investigation of oral itraconazole in stratum corneum level of tinea pedis.in the present study, the authors administered 100 mg itraconazole (itcz) twice daily for a period of 1 week to six patients with hyperkeratotic type tinea pedis, and examined its efficacy, safety profile, and usefulness. itcz concentration in stratum corneum was also measured to examine the mobility of the drug into the affected site of planta pedis. itcz concentration in the stratum corneum of the affected part was first detected at 1 week after the completion of administration, gradually incr ...200415078426
cloning and functional expression of a mungbean defensin vrd1 in pichia pastoris.it was shown previously that a bacterially expressed mungbean defensin vrcrp exhibited both antifungal and insecticidal activities. to isolate this protein in a large quantity for its characterization, the defensin cdna was expressed in pichia pastoris and the recombinant defensin (rvrd1) was purified. the recombinant vrd1 was shown to inhibit the growth of fungi such as fusarium oxysporum, pyricularia oryza, rhizoctonia solani, and trichophyton rubrum and development of bruchid larva. the prote ...200415080630
superficial mycoses and hiv infection in yaounde.the incidence of superficial infections in patients with human immunodeficiency virus (hiv) is increasing in yaounde. to determine the prevalence of superficial mycoses in hiv-positive subjects, a study was carried out in different hospital settings in yaounde over a period of 18 months. clinical observations were followed by the culture of samples on sabouraud's glucose agar. of the 148 hivab-positive patients examined, 79 (44 males and 35 females) had at least one superficial mycosis (53%). th ...200415096139
epidemiologic surveillance of cutaneous fungal infection in the united states from 1999 to 2002.cutaneous fungal infections are common in the united states, and causative organisms include dermatophytes, yeasts, and nondermatophyte molds. these organisms are in constant competition for their particular environmental niche, often resulting in the emergence of one or more predominant pathogens and displacement of other less competitive species. changes in the incidence of fungal pathogens can be followed from laboratory culture results of infected cutaneous tissues over time. these data can ...200415097959
a comparative survey of serum androgenic hormones levels between male patients with dermatophytosis and normal subjects.fungal growth can be influenced by human physiological mediators such as androgenic hormones. the aim of this study was to investigate a possible relationship between androgenic hormones and susceptibility to dermatophytosis. to this purpose we measured the levels of testosterone, androstendione, and dehydroepianderosterone sulfate (dhea-s) in 60 male patients with dermatophytosis due to epidermophyton floccosum and trichophyton rubrum by enzyme link immunoassay. serum testosterone concentration ...200415118212
antifungal drug response in an in vitro model of dermatophyte nail infection.despite terbinafine being fungicidal against trichophyton rubrum in standard nccls assays and rapidly accumulating in nails in vivo, onychomycosis patients require prolonged terbinafine treatment to be cured. to investigate this, we developed a more clinically relevant onychomycosis in vitro test model. human nail powder inoculated with t. rubrum and incubated in liquid rpmi 1640 salt medium, which did not support growth alone, developed extensive and invasive mycelial growth. antifungal drugs w ...200415124869
prevalence of fungal foot infections in patients with diabetes mellitus type 1 - underestimation of moccasin-type tinea.in diabetic patients, mycotic infections may increase the risk of developing diabetic foot syndrome. however, few data are available on the prevalence of fungal foot infections in patients with diabetes. during a conference attended by patients with long-term diabetes, 95 individuals with type 1 diabetes mellitus (52 men, 43 women, mean disease duration 35.8 years) were examined for fungal infections of the feet. as well as frequency of infection and risk profiles, the level of patient awareness ...200415146373
severe generalized deep dermatophytosis due to trichophyton rubrum (trichophytic granuloma) in a patient with atopic dermatitis. 200415148118
agar sublimation test for the in vitro determination of the antifungal activity of morpholine derivatives.we studied the in vitro antifungal activities of a wide range of antimycotic agents, including amorolfine, terbinafine, naftifine, five morpholine derivatives, ciclopiroxolamine, bifonazole, clotrimazole, ketoconazole, itraconazole, fluconazole, voriconazole, flucytosine, amphotericin b, nystatin, and caspofungin, against candida albicans and trichophyton rubrum by conventional agar diffusion tests and by a novel sublimation method. for the sublimation method, 6 mm filter paper disks were soaked ...200415189181
the successful treatment of trichophyton rubrum nail bed (distal subungual) onychomycosis with intermittent pulse-dosed terbinafine.the standard treatment of trichophyton rubrum nail bed onychomycosis (or distal subungual onychomycosis [dso]) with daily terbinafine for 12 weeks involves treating for a fixed period shorter than the time required for complete replacement of the nail bed and overlying nail plate by normal growth. the same total amount of terbinafine pulse-dosed for approximately 12 months would treat the patient until normal replacement of the mycotic nail bed has occurred.200415210459
white superficial onychomycosis: epidemiological, clinical, and pathological study of 79 patients.to analyze the epidemiology, responsible agents, clinical features, and outcome of white superficial onychomycosis (wso).200415210460
intra- and interlaboratory study of a method for testing the antifungal susceptibilities of dermatophytes.the national committee for clinical laboratory standards (nccls) m38-a standard for the susceptibility testing of conidium-forming filamentous fungi does not explicitly address the testing of dermatophytes. this multicenter study, involving six laboratories, investigated the mic reproducibility of seven antifungal agents tested against 25 dermatophyte isolates (5 blinded pairs of five dermatophyte species per site for a total of 300 tests), using the method of dermatophyte testing developed at t ...200415243047
cloning and characterization of trichophyton rubrum genes encoding actin, tri r2, and tri r4.the three structural genes of trichophyton rubrum encoding actin (3,429 bp) and two antigens, tri r2 (2,950 bp) and tri r4 (3,988 bp), were cloned and characterized. they contained six, four, and five exons, respectively. the t. rubrum actin protein sequence revealed extremely high homology to other fungal actins.200415243098
photodynamic treatment of the dermatophyte trichophyton rubrum and its microconidia with porphyrin photosensitizers.the application of photosensitizers for the treatment of fungal infections is a new and promising development within the field of photodynamic treatment (pdt). dermatophytes, fungi that can cause infections of the skin, hair and nails, are able to feed on keratin. superficial mycoses are probably the most prevalent of infectious diseases in all parts of the world. one of the most important restrictions of the current therapeutic options is the return of the infection and the duration of the trea ...200415244503
scanning electron microscope imaging of onychomycosis.although scanning electron microscope technology has been used for more than 60 years in many fields of medical research, no studies have focused on obtaining high-resolution microscopic images of onychomycosis of the toenail caused by trichophyton rubrum in a geriatric population. to provide new insight into the intricate structure and behavior of chronic toenail onychomycosis, we produced three-dimensional images of onychomycosis obtained from two geriatric patients with confirmed growth of t ...200415265994
frequency and risk factors of dermatophytosis in students living in rural areas in eskişehir, turkey.our study included 2384 students from five villages around eskişehir, turkey. we asked every student for their personal identification and also for their sanitation in order to get an idea about dermatophytosis. samples taken from suspicious lesion were collected and inoculated onto sabouraud dextrose agar slants. for identification of fungi which were grown, macroscopic appearance of colonies, microscopic examination and biochemical tests were used. we found suspicious lesions in 245 (10.3%) an ...200415281399
onychomycosis caused by an isolate conforming to the description of trichophyton raubitschekii.trichophyton raubitschekii is currently regarded as a synonymous name betokening a variant form of trichophyton rubrum. nonetheless, isolates conforming to this morphotaxonomic concept have morphological, physiological and clinical features very different from those of typical t. rubrum. isolates are mainly obtained from subjects originating from certain tropical and subtropical countries, and are mainly obtained from upper body skin infections, rarely from onychomycosis. in this paper the autho ...200415283242
[a case of tinea capitis with a couple of nodular lesions possibly resulting from topical application of tacrolimus].we herein report a case of tinea capitis initially showing a couple of nodular lesions. the patient was a 66-year-old woman who had seen a nearby dermatologist for itching on her head and had been treated with a topical steroid followed by tacrolimus application for one month. because pseudolymphoma-like erythematous nodules developed at two sites, she visited us. two weeks after stopping all medication, some slight scaling was found around these nodules. on koh direct microscopic examination, m ...200415284831
dermatophytosis in children and adolescents in gdansk, poland.during a 3-year period (1999-2001) a total of 94 cases of dermatophytosis were seen in patients from 0 to 18 years of age attending the department of dermatology, venerology and allergology of gdańsk medical university. mycoses were diagnosed on the basis of clinical picture and direct microscopy and were confirmed by positive cultures. the most frequent pathogens were microsporum canis (62%) and trichophyton rubrum (12%). the most often forms of dermatophytosis in children were tinea cutis glab ...200415310339
the novel azole r126638 is a selective inhibitor of ergosterol synthesis in candida albicans, trichophyton spp., and microsporum canis.r126638 is a novel triazole with in vitro activity similar to that of itraconazole against dermatophytes, candida spp., and malassezia spp. in animal models of dermatophyte infections, r126638 showed superior antifungal activity. r126638 inhibits ergosterol synthesis in candida albicans, trichophyton mentagrophytes, trichophyton rubrum, and microsporum canis at nanomolar concentrations, with 50% inhibitory concentrations (ic(50)s) similar to those of itraconazole. the decreased synthesis of ergo ...200415328084
evaluation of the drug treatment and persistence of onychomycosis.onychomycosis is a common nail disease responsible for approximately 50% of diseases of the nail. it occurs more in the elderly, though several cases have been reported among children. several factors influence, such as climate, geography, and migration. the two dermatophytes most commonly implicated in onychomycosis are trichophyton rubrum and t. mentagrophytes, accounting for more than 90% of onychomycoses. nonetheless, several other toxigenic molds have been implicated. for convenience, onych ...200415349516
secreted subtilisin gene family in trichophyton rubrum.secreted proteases constitute potential virulence factors of dermatophytes. a total of seven genes encoding putative serine proteases of the subtilisin family (sub) were isolated in trichophyton rubrum. based on sequence data and intron-exon structure, a phylogenetic analysis of subtilisins from t. rubrum and other fungi revealed a presumed ancestral lineage comprising t. rubrum sub2 and aspergillus subs. all other subs (sub1, sub3-7) are dermatophyte-specific and have apparently emerged more re ...200415363848
[clinical and parasitological observations on a second algerian case of cutaneous trichophytosis due to trichophyton rubrum]. 195015414004
benign course of dermatophytosis due to combined infection with epidermophyton floccosum and trichophyton rubrum; report of a case. 195015433438
origins of microsatellite diversity in the trichophyton rubrum-t. violaceum clade (dermatophytes).we analyzed the population structure of the anthropophilic dermatophyte species trichophyton violaceum, which mainly causes tinea capitis, and t. rubrum, the most frequently isolated agent of dermatophytosis worldwide. a microsatellite marker (t1) was developed by using the enrichment technique for microsatellites. the t1 marker containing a (gt)(8-10) repeat was proven to specifically amplify both species, underlining their close kinship. four polymorphic alleles were detected within a set of a ...200415472291
[contribution to the study of dermatomycosis in catalonia].we report the results of a study which aim was the mycological identification of specimens coming from patients included in a clinical trial. a total of 445 specimens from patients with clinical diagnosis of dermatomicosis were processed during 8 months (138 pityriasis versicolor, 28 cutaneous candidosis and 279 dermatophytosis). a 48% of pityriasis versicolor cultures were positive for malassezia furfur, 50% of candidosis cultures were positive for yeasts and 67% of dermatophytosis cultures wer ...199715482021
in vitro susceptibility testing of amorolfine in pathogenic fungi isolated from dermatomycosis patients in china.the antifungal susceptibility of isolates from chinese dermatomycosis patients to amorolfine was investigated following national committee for clinical laboratory standards (nccls) protocols. in total, 383 isolates were tested, including 132 strains from tinea pedis, 148 strains from tinea corporis/cruris, and 103 strains from onychomycosis. the minimum inhibitory concentration (mic) of amorolfine against dermatophytes ranged from 0.01 to 0.08 microg ml(-1). the mic(50) and mic(90) of amorolfine ...200415504124
trichoderma spp. antagonism to the dermatophyte trichophyton rubrum: implications in treatment of onychomycosis.onychomycosis--the dermatophytic invasion of the nail--is difficult to eradicate with drug treatment. the hyphae of the main invading pathogen, trichophyton rubrum, are often interwoven with the nail plate, preventing effective anti-mycotic agents from reaching its growing tips. an alternative approach to treat onychomycosis may possibly be the application of a biological control agent against the pathogen. in analogy with the success of biocontrol of phytopathogenic fungi, we screened a series ...200415518345
onychomycosis in cali, colombia.this study presents the epidemiological and mycological aspects of 299 patients with nail lesions who were referred to three diagnostic laboratories in the city of cali. the diagnosis of mycoses was established through visualization of mycotic structures in a direct microscopic examination of skin scrapings and by isolation. onychomycosis was found in 183 cases (61.2%), of which 141 were in toenails (44 in males and 97 in females), 38 in fingernails (9 males and 29 females), and 4 cases in toena ...200415518346
low-voltage direct current as a fungicidal agent for treating onychomycosis.onychomycosis, most commonly caused by two species of dermatophyte fungi--trichophyton rubrum and trichophyton mentagrophytes--is primarily treated with regimens of topical and systemic antifungal medications. this study was undertaken to evaluate in vitro the efficacy of low-voltage direct current as an antifungal agent for treating onychomycosis. agar plate cultures of t rubrum and t mentagrophytes were subjected to low-voltage direct current electrostimulation, and antifungal effects were obs ...200415547124
antifungal activities of essential oils from thymus quinquecostatus and t. magnus.the antifungal activities of essential oils from thymus quinquecostatus and t. magnus, which are species native to korea, were evaluated against seven common pathogenic fungi. additionally, the effects of the oils together with ketoconazole were tested by the checkerboard titer test. both of the two thymus oils showed significant inhibition of the tested fungi, with minimal inhibitor concentrations (mics) and minimal fungicidal concentrations (mfcs) in the range of 0.04-0.39 mg/ml and 0.19-0.78 ...200415549669
morphological evidences for onion-induced growth inhibition of trichophyton rubrum and trichophyton mentagrophytes.the antifungal activity of onion (allium cepa l.) on two important dermatophytes, trichophyton rubrum and trichophyton mentagrophytes, with special reference to morphological aspects was studied. growth of both fungi was found to be strongly inhibited by aqueous onion extract (aoe) as a dose-dependent manner. the extract showed fungicidal effect for both fungi at concentrations >3.12% (v/v). the fungus t. mentagrophytes was more affected by the onion as compared to t. rubrum at all concentration ...200415567239
deep dermatophytosis caused by trichophyton rubrum with concomitant disseminated nocardiosis in a renal transplant recipient.deep dermatophytosis and nocardiosis are uncommon infections. this article describes a patient who was immunosuppressed with deep dermatophytosis caused by trichophyton rubrum and concurrent disseminated nocardiosis. the infections occurred 16 years after the patient underwent renal transplantation, and may have been related to tacrolimus therapy.200415577763
antibacterial and xanthine oxidase inhibitory cerebrosides from fusarium sp. ifb-121, an endophytic fungus in quercus variabilis.two antibacterial and xanthine oxidase inhibitory cerebrosides, one of which is chemically new, were characterized from the chloroform-methanol (1:1) extract of fusarium sp. ifb-121, an endophytic fungus in quercus variabilis. by means of chemical and spectral methods [ir, electrospray ionization ms (esi-ms), tandem esi-ms, 1h and 13c nmr, distortionless enhancement by polarization transfer, cosy, heteronuclear multiple-quantum coherence, heteronuclear multiple-bond correlation, and 2-d nuclear ...200415588024
dermatophytes in the rural area of duzce, turkey.a total of 227 subjects (112 were male and 115 female), who were residents of the rural region of duzce, were examined for dermatomycosis. a total of 120 samples (47 nail fragments, 73 skin scales) were collected from 81 patients for mycological analysis on the basis of the results of clinical evaluation. all specimens collected were analysed by direct microscopy and culture. positive results were detected in the cultures of 53 (44.1%) of the 120 samples. about 46 (86.7%) samples also presented ...200415601451
bullous tinea pedis in two children.tinea pedis is a dermatophytic infection with a high prevalence in adults and also occasionally observed in children. we report here two cases of bullous tinea pedis, one due to trichophyton rubrum in a 6-year-old child and the second due to t. interdigitale in a 10-year-old child. we suggest that, despite the low prevalence of this infection in childhood, a potassium hydroxide test and a culture for fungi should always be performed when a child is examined for an inflammatory eruption of the fe ...200415601452
[the raubitschekii variant of trichophyton rubrum has reached germany].this is the second report on an isolation of the variety raubitschekii of trichophyton (t.) rubrum in germany. the patient was a young man born in cameroon who presented with an extensive tinea corporis et manuum. the variety raubitschekii can be distinguished from similar looking dermatophytes by its brownish color, by the formation of abundant t. rubrum-like macroconidia, by the production of urease, by a negative hair perforation test, and by dna analysis. in addition, further characteristics ...200515619081
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