| [new antimicrobial agent series, xxvii: rokitamycin]. | | 1987 | 3127613 |
| isolation of mycoplasma pneumoniae from synovial fluid samples in a patient with pneumonia and polyarthritis. | a patient with a long history of arthritis developed pneumonia. two weeks into her hospital course, the patient developed effusions in her knee and wrist that yielded cultures positive for mycoplasma pneumoniae. to our knowledge, this is the third reported case of m pneumoniae isolation from a joint and the first report of isolation of m pneumoniae from two joints in a patient without hypogammaglobulinemia. the evidence suggests that in individuals with atypical pneumonia and joint effusions, m ... | 1988 | 3128197 |
| prevalence of chlamydia trachomatis and mycoplasma pneumoniae in children with and without pharyngitis. | the prevalence of chlamydia trachomatis, mycoplasma pneumoniae, group a beta-hemolytic streptococcus, and other treatable organisms was studied in children with and without pharyngitis. children aged 2 to 12 years were evaluated between november 1985 and april 1986 in three family practice offices in the salt lake city area. chlamydia trachomatis was not detected in the pharynx of any of the children studied. mycoplasma pneumoniae was cultured from 5 percent of the 242 children studied, group a ... | 1988 | 3128634 |
| nonrespiratory complications of m. pneumoniae infection. | mycoplasma pneumoniae infection occurs in more than 10 million americans each year. most patients have a mild respiratory illness; only 5 percent develop clinical pneumonia. nonrespiratory complications may involve skin, joints, central nervous system, heart, liver, kidneys or blood; some lead to significant morbidity and mortality. immune-inflammatory responses appear to be the cause of these manifestations. | 1988 | 3128944 |
| [infection caused by mycoplasma pneumoniae]. | | 1988 | 3129146 |
| isolation of mycoplasma pneumoniae from children with lower-respiratory-tract infections. | the prevalence and clinical pictures of mycoplasma pneumoniae infections among children were studied using culture and serological techniques. the isolation rate was 22% (195 of 885) in pneumonic patients and 11% (66 of 600) in non-pneumonic patients. in patients three years of age or less, m. pneumoniae was isolated at the same rate from febrile and afebrile cases and from wheezy and non-wheezy cases. in older patients, however, m. pneumoniae was frequently isolated from febrile but non-wheezy ... | 1988 | 3129522 |
| [effects of several macrolide antibiotics on mycoplasma pneumoniae--susceptibility of m. pneumoniae infected l cells to macrolide antibiotics]. | | 1987 | 3130440 |
| mycoplasma and ureaplasma in bronchoalveolar lavage fluids from immunocompromised hosts. | the significance of mycoplasma spp. and ureaplasma urealyticum infection in immunocompromised patients has not been clearly established. we identified mycoplasma or ureaplasma in bronchoalveolar lavage fluid from 12 of 61 (20%) immunocompromised patients with pulmonary infiltrates. a complete microbiological investigation was made on the bronchoalveolar lavage fluids, and mycoplasma pneumoniae was the sole agent detected in three instances, suggesting that it may have been the cause of the infil ... | 1988 | 3131061 |
| [effect of immunosuppressive therapy on the occurrence of infectious complications]. | | 1987 | 3132877 |
| comparison of gen-probe commercial kit and culture technique for the diagnosis of mycoplasma pneumoniae infection. | the gen-probe rapid diagnostic system was compared with a culture method for the detection of mycoplasma pneumoniae in clinical specimens. of 116 clinical specimens, 103 (88.8%) yielded identical results. the relative sensitivity and specificity of the probe were both 89%. rapid turnaround time and its sensitivity and specificity indicate that the probe test is a practical method for the rapid diagnosis of m. pneumoniae infections. | 1988 | 3133385 |
| [study of the attachment of mycoplasma pneumoniae using enzyme-linked immunosorbent assay]. | | 1988 | 3135359 |
| [in vitro activity of new quinolones against mycoplasma pathogenic to humans]. | the in vitro activity of new quinolones was evaluated against mycoplasma pneumoniae (10 strains) and mycoplasma hominis (approximately equal to 70 strains) by agar dilution, and against ureaplasma urealyticum (approximately equal to 115 strains) by broth dilution. the static effect of pefloxacin, ofloxacin, ciprofloxacin, enoxacin was investigated for all the strains. rosoxacin was included in the tests for u. urealyticum and m. hominis. pefloxacin, ofloxacin, ciprofloxacin and enoxacin were wit ... | 1988 | 3136430 |
| [clinical study of m. pneumoniae infections in children]. | | 1988 | 3136891 |
| prospective study on the etiology of community-acquired pneumonia in children and adults in spain. | the cause of primary pneumonia was diagnosed in 157 of 198 children and 165 of 207 adults seen as inpatients or outpatients in a 12-month period. in children mycoplasma pneumoniae and pneumococcus were identified in 79 and 29 cases respectively. twenty-nine of 53 cases of viral infection in children were caused by respiratory syncytial virus, two-thirds of the cases occurring in children under three years of age. no children died of pneumonia. in adults pneumococcus was the most common pathogen, ... | 1988 | 3137033 |
| etiological diagnosis of pneumonia in military conscripts by combined use of bacterial culture and serological methods. | the combined use of microbiological, serological and clinical laboratory methods was evaluated for etiological diagnosis of pneumonia in 106 military conscripts. special attention was paid to rapid diagnosis of pneumococcal pneumonia and its differentiation from viral and mycoplasmal pneumonia. the microbial etiology could be established in 91 (86%) of the pneumonia patients. pneumococcal etiology was definitely established in 32 (30%) patients and considered probable in an additional 21 patient ... | 1988 | 3137034 |
| enzyme-linked immunosorbent assay for detection of mycoplasma pneumoniae specific immunoglobulin m. | an elisa was developed for the detection of igm antibodies to mycoplasma pneumoniae in human sera, using microtiter plates coated with rabbit antiserum to human igm selecting for igm antibodies in the first reaction step. the specific antibodies were detected using enzyme-labelled, detergent-solubilized antigen. the complement fixation test was used as reference method. in a prospective study of 59 patients with community-acquired pneumonia, 13 of whom had evidence of mycoplasmal etiology, the e ... | 1988 | 3137050 |
| parameters of mycoplasma pneumoniae infection in syrian hamsters. | an animal model for evaluating the potency of mycoplasma pneumoniae vaccines was developed with hamsters. factors that influence hamster infection by m. pneumoniae were defined, and parameters for assessment of intensity of pulmonary disease were established. colonization of hamster lungs was determined by culture, and intensity of lung disease was assessed histopathologically and expressed numerically as a lung pathological score. intratracheal inoculation of the challenge was superior to the i ... | 1988 | 3137169 |
| hamster challenge potency assay for evaluation of mycoplasma pneumoniae vaccines. | a hamster immunization challenge assay described in the accompanying paper (m. f. barile, d. k. f. chandler, h. yoshida, m. w. grabowski, r. harasawa, and s. razin, infect. immun. 56:2443-2449, 1988) was used to examine protection against mycoplasma pneumoniae disease by passive immunization and to evaluate the protective potency of a formalin-inactivated whole-cell and a cell extract m. pneumoniae vaccine. passive immunization with a globulin fraction of hyperimmune mule antiserum to m. pneumon ... | 1988 | 3137170 |
| [lymphocyte subsets in relation to immunosuppression in mycoplasma pneumoniae pneumonia]. | | 1988 | 3137286 |
| repetitive dna sequences in mycoplasma pneumoniae. | two types of different repetitive dna sequences called repmp1 and repmp2 were identified in the genome of mycoplasma pneumoniae. the number of these repeated elements, their nucleotide sequence and their localization on a physical map of the m. pneumoniae genome were determined. the results show that repmp1 appears at least 10 times and repmp2 at least 8 times in the genome. the repeated elements are dispersed on the chromosome and, in three cases, linked to each other by a homologous dna sequen ... | 1988 | 3138660 |
| ultrastructure of mycoplasma pneumoniae exposed to macrolide antibiotics during cultivation on a glass surface and in an organ culture, in relation to their mycoplasma-killing activity. | the macrolide antibiotics midecamycin acetate (mom), erythromycin (em), midecamycin (mdm), josamycin (jm) and rokitamycin (rkm) showed killing activity against mycoplasma pneumoniae strain fh-p24. the activity of mom, em and jm was not influenced by the number of organisms inoculated, but that of rkm was markedly decreased by a large inoculum. scanning electron microscopic observations showed many long filaments crossing over each other with small colonies when the organisms were cultivated on a ... | 1988 | 3139385 |
| igm binding to sialosyllactosaminylparagloboside in a patient with polyradiculoneuropathy due to mycoplasma pneumoniae infection. | igm in serum without paraprotein in a patient with polyradiculoneuropathy due to a mycoplasma pneumoniae infection reacted specifically with a ganglioside, sialosyllactosaminylparagroboside (slpg), in a human peripheral nerve on a thin-layer chromatogram plate by an immunostaining technique. this finding suggests the possibility that anti-slpg antibody in the patient's serum may play a role in the pathogenesis of neuropathy. | 1988 | 3140569 |
| carbohydrate structures as onco-developmental antigens and components of receptor systems. | | 1988 | 3140611 |
| culture-amplified immunological detection of mycoplasma pneumoniae in clinical specimens. | we have employed a monoclonal antibody directed to a mycoplasma pneumoniae membrane-associated protein antigen in a culture-amplified detection system. eleven culture-positive sputum specimens were detected significantly more early by the immunoassay. specimens culture-positive for other probable mycoplasma spp. were negative by this technique. | 1988 | 3141107 |
| evidence for occurrence of passively adsorbed i antigen activity on a cultured strain of mycoplasma pneumoniae. | the aim of this study was to investigate whether i antigen occurs in association with mycoplasma pneumoniae in a form that may be immunogenic during natural infection or experimental immunization. i antigen activity was detected by radioimmunoassay in suspensions of m. pneumoniae my11965 and in the soluble phase of mycoplasma lysates prepared with triton x-100. there was evidence for the occurrence of i antigen in at least two macromolecular forms. the first form partitioned in the lipid phase f ... | 1988 | 3141277 |
| regions of mycoplasma pneumoniae cytadhesin p1 structural gene exist as multiple copies. | the mycoplasma pneumoniae cytadhesin p1 structural gene with flanking regions was labeled by nick translation and used as a probe to analyze gene copy number in m. pneumoniae. multiple bands of genomic dna were hybridized by the probe. to establish what part of the p1 gene existed as multiple copies, the p1 gene and regions adjacent to the 3' and 5' ends were divided with restriction enzymes into 14 segments ranging in size from 174 to 651 base pairs. these pieces were purified on agarose gels, ... | 1988 | 3141282 |
| numerical analysis of page protein patterns and the taxonomic relationships within the 'mycoplasma mycoides cluster'. | twenty-six isolates belonging to the 'mycoplasma mycoides cluster' have been characterized by one-dimensional sds-page of their cellular proteins. a numerical classification based on the resulting patterns and using a correlation coefficient revealed four distinct phenons at a similarity (s) level of 70%, comprising: (a) bovine group 7 strains; (b) m. capricolum and f38-like strains; (c) m. mycoides subsp. capri and lc strains ('subsp. mycoides'); (d) m. mycoides subsp. mycoides (sc). at the 75% ... | 1987 | 3141559 |
| presence of anaplerotic reactions and transamination, and the absence of the tricarboxylic acid cycle in mollicutes. | cell extracts of the fermentative mollicutes acholeplasma laidlawii b-pg9, acholeplasma morum s2, mycoplasma capricolum 14, mycoplasma gallisepticum s6, mycoplasma pneumoniae fh, mycoplasma hyopneumoniae j and m. genitalium g-37, and the non-fermentative mycoplasma hominis pg-21, mycoplasma hominis 1620 and mycoplasma bovigenitalium pg-11 were examined for 39 cytoplasmic enzyme activities associated with the tricarboxylic acid (tca) cycle, transamination, anaplerotic reactions and other enzyme a ... | 1988 | 3141576 |
| [mycoplasma pneumoniae cultured from a healthy population aged 8 to 16]. | throat cultures have been taken from 100 persons on may 1986 and 100 persons on december 1986. finally 200 throat cultures have been taken and cultures were determined for m. pneumoniae. m. pneumoniae has been isolated in 3 female and 2 male cases which sum up to 5 cases (2.5%). all these cases were asymptomatic and 8-16 old-year. all samples has taken in spring. these show parallelism with other research in the same subject. the isolation of m. pneumoniae in 2.5 percent has shown that m. pneumo ... | 1987 | 3141751 |
| [characteristics of the immunologic response to mycoplasma pneumoniae as a polyclonal lymphocyte activator]. | m. pneumoniae, used as mitogen, was shown to initiate the synthesis of antibodies to salmonellae in the culture of lymphocytes obtained from healthy donors as actively as lectins and staphylococcus aureus protein a. in these experiments igg antibodies were mainly synthesized. the serological study of a group of persons (333 subjects) for 2.5 years revealed that seroconversion to m. pneumoniae and simultaneously to viruses occurred in 78% of cases. in more than a half of the cases a rise in the t ... | 1988 | 3143202 |
| [accelerated laboratory diagnosis of bacterial pneumonia]. | the effectiveness of countercurrent immunoelectrophoresis (cie) used for the accelerated differential diagnosis of pneumococcal, staphylococcal, mycoplasmal and legionella infections in cases of pneumonia has been shown. the presence of correlation between the results obtained in the bacterial study of sputa and bronchial washings and in cie has been revealed, which gives grounds for recommending cie for the accelerated diagnosis of pneumococcal pneumonia on the basis of the analysis of sputa, b ... | 1988 | 3143206 |
| in vitro activity of florphenicol. | florphenicol was active at a lower concentration than chloramphenicol against over half of 234 recent clinical bacterial isolates. the majority (98%) of the isolates were inhibited by florphenicol at a concentration of 8 mg/l or less. florphenicol was particularly effective against chloramphenicol resistant strains of haemophilus influenzae. klebsiella aerogenes and bacteroides spp. florphenicol was bacteristatic for salmonellae and escherichia coli but bactericidal for haemophilus influenzae. f ... | 1988 | 3143587 |
| mesothelial cell proliferation and localized pleural pseudotumour associated with mycoplasma pneumoniae infection. | a 9-year-old boy had serological evidence of mycoplasma pneumoniae infection. mycoplasma organisms were cultured from throat swabs. a chest x-ray and computed tomography revealed a localized pleural tumour with pleural fluid containing mesothelial cells. it is suggested that mesothelial cell hyperplasia developed as a "reactive change" following m. pneumoniae infection. | 1988 | 3143593 |
| laboratory diagnosis of mycoplasma pneumoniae infection. 1. direct detection of antigen in respiratory exudates by enzyme immunoassay. | direct and indirect antigen capture enzyme immunoassays (ag-eia) have been developed for the detection of mycoplasma pneumoniae in nasopharyngeal aspirates or sputum from respiratory infection. the sensitivity of the two ag-eia were similar, but the indirect method using polyclonal rabbit and guinea-pig antisera was more convenient. the ag-eia had a detection limit of 10(4-4.5) colony-forming units/ml of sample. it was specific for m. pneumoniae and gave a low level response with m. genitalium. ... | 1988 | 3145891 |
| laboratory diagnosis of mycoplasma pneumoniae infection. 2. comparison of methods for the direct detection of specific antigen or nucleic acid sequences in respiratory exudates. | the efficiency of the direct detection of mycoplasma pneumoniae in respiratory exudates by an antigen capture, indirect enzyme immunoassay (ag-eia), has been compared with its detection with a cdna probe ('gen-probe assay') directed against the specific ribosomal rna sequences of the organism ('mycoplasma pneumoniae rapid diagnostic system', gen-probe, san diego, california). both assays showed excellent specificity against a range of mycoplasma species suspended in negative nasopharyngeal aspir ... | 1988 | 3145892 |
| [species-specific monoclonal antibodies against mycoplasma pneumoniae: antibody specificities, antigen characterization, and rapid antigenic detection method]. | | 1988 | 3146601 |
| detection of specific igm antibodies for the diagnosis of mycoplasma pneumoniae infections: a clinical evaluation. | the diagnostic value of detection of specific igm antibodies was analysed in mycoplasma pneumoniae infections. in a retrospective clinical and serological study, m. pneumoniae igm antibodies were determined by a mu-capture elisa using enzyme-labelled antigen. the study group consisted of 91 patients with significantly raised titers in paired sera or a single high titer of complement fixation antibodies. about 40% of the patients had been treated with antibiotics ineffective against m. pneumoniae ... | 1988 | 3146809 |
| in vitro influence of mycoplasma species on the stimulation of human polymorphonuclear granulocytes. | the influence of mycoplasma species (sp.) on the stimulation of human polymorphonuclear neutrophil granulocytes (pmng) was determined by means of the luminol-dependent chemiluminescence (cl) method. when opsonized mycoplasma sp. were used the cl response of pmng was greater than in the presence of nonopsonized strains. nonopsonized and nonspecifically opsonized mycoplasma sp. showed a different cl response pattern. the stimulation of pmng was with m. pneumoniae significantly weaker than with the ... | 1988 | 3146844 |
| dna probe versus culture for detection of mycoplasma pneumoniae in clinical specimens. | the laboratory diagnosis of mycoplasma pneumoniae is often difficult because of lengthy and complicated cultural methods and serological tests that may be both insensitive and nonspecific. in this study, 82 patients suspected of mycoplasma pneumonia were cultured for m. pneumoniae, and their respiratory secretions were tested by a dna probe for m. pneumoniae. the probe test was 100% sensitive and 98% specific compared to culture. this dna probe, then, is an effective alternative method for the d ... | 1988 | 3147159 |
| [survey of the antibody level of mycoplasma pneumonia in healthy population in yunnan province]. | | 1988 | 3147812 |
| development of urease conjugated enzyme-linked immunosorbent assays (elisa) for the detection of igm and igg antibodies against mycoplasma pneumoniae in human sera. | urease conjugated enzyme linked immunosorbent assays (elisa) were developed for the detection of human igm and igg antibodies against mycoplasma pneumoniae. results obtained by elisa were compared with complement fixation test (cft); which showed that of the 214 serum specimens tested, 80 were found to have antibody against m. pneumoniae. elisa revealed that 70 of these specimens were igg antibody, and 27 of them also contain igm antibody. cft failed to detect the presence of antibody against m. ... | 1988 | 3147832 |
| [the isolation of mycoplasma from the bronchoalveolar lavage fluid and its antibody titer measurement in chronic obstructive pulmonary disease]. | | 1988 | 3148372 |
| isolation and characterization of mycoplasma genitalium strains from the human respiratory tract. | mycoplasma genitalium, an organism first isolated from the urethras of two men with nongonococcal urethritis, has been found in throat specimens from military recruits participating in an inactivated mycoplasma pneumoniae vaccine field trial in 1974-1975. four of 16 preserved throat isolates, previously identified as strains of m. pneumoniae, have now been shown to be mixtures of m. pneumoniae and m. genitalium. purification of these mixed mycoplasmas by selection of single colonies confirmed th ... | 1988 | 3148632 |
| isolation of the adherence protein of mycoplasma pneumoniae by fractionated solubilization and size exclusion chromatography. | the 168-kda adherence protein of m. pneumoniae was solubilized and purified to homogeneity. optimal yield was obtained by pretreatment of whole m. pneumoniae cells with buffer containing 1% chaps and subsequent extraction with octylglucosid at a detergent to protein ratio of 5 and at octylglycoside concentrations between 1.5 and 2%. contaminating membrane proteins with high molecular masses were removed by pretreatment with 1% chaps and proteins of low molecular masses by size exclusion chromato ... | 1988 | 3149486 |
| [studies on the infection with mycoplasma pneumoniae. (i)--isolation of m. pneumoniae and clinicopathological analysis]. | | 1988 | 3150016 |
| concomitant mycoplasma pneumoniae and virus infection in children with acute lower respiratory infections. | | 1988 | 3150211 |
| preparative electroelution of specific protein antigens from mycoplasma pneumoniae: use in an enzyme-linked immunosorbent assay (elisa). | a rapid, simple and preparative method is described for the recovery of the seven highest molecular weight proteins (hmwp) from mycoplasma pneumoniae membrane. the yield of proteins obtained was approximately 90%. the method involved the separation of m. pneumoniae proteins by sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page), followed by electroelution of hmwp. these eluted antigens were used in an elisa to measure igg antibodies in sera from 9 blood donors and 9 patients wi ... | 1988 | 3150937 |
| longitudinal study on the therapy of mycoplasma pneumoniae infections with ciprofloxacin on syrian hamsters. | | 1987 | 3151338 |
| severe mycoplasma pneumonia in three sisters with sickle cell disease. | mycoplasma pneumoniae, which usually causes mild infections in normal children, has been shown to cause isolated cases of severe pneumonia in children with sickle cell disease. we recently observed an outbreak of mycoplasma pneumonia in three sisters with homozygous sickle cell disease. two of them required hospitalization, and one progressed to respiratory failure requiring prolonged ventilatory assistance. all eventually recovered without long-term pulmonary complications. familial outbreaks a ... | 1986 | 3153238 |
| [membranoproliferative glomerulonephritis and mycoplasma pneumoniae infection]. | on the occasion of a new case and review of 9 others in the literature, the authors seek to establish the hallmarks of the nephritis occurring after m. pneumoniae infection. it often consists of an acute nephritic syndrome, 10 to 40 days after a respiratory tract infection; hematological abnormalities are not constant. histological examination of the kidney shows a type i membranoproliferative glomerulonephritis in 2, dense deposit disease in 2 and tubulo-interstitial nephritis in one. immunoflu ... | 1985 | 3157358 |
| immunological reaction of guinea-pigs following intranasal mycoplasma pneumoniae infection and immunization with the 168 kda adherence protein. | humoral responses to mycoplasma pneumoniae proteins, especially the 168 kda protein, were demonstrated by western blotting in sera and bronchial washings of all groups of infected or immunized guinea-pigs. however, infection was not prevented by these local and systemic antibodies. hilar lymphocytes of infected and immunized guinea-pigs were stimulated in vitro by sonicated m. pneumoniae antigen and by the 168 kda protein. stimulation was significantly lower in animals which had been infected tw ... | 1988 | 3171546 |
| changes in the epidemiological pattern of mycoplasma pneumoniae infections in denmark. a 30 years survey. | a seroepidemiological survey has shown a remarkable shift in the previously reported regular cyclic pattern of mycoplasma pneumoniae epidemics which culminated every 4.5 years during the period 1958-74. the last of four regular epidemics occurred in 1972. it was followed by 'premature' epidemics in 1975 and 1977/8 which inaugurated a change from an epidemic to an endemic pattern of the infection in denmark. over the following 9 years (1978-86) there has been an irregular but significant decrease ... | 1988 | 3181319 |
| rapid etiological diagnosis of pneumonia in young men. | the major findings and conclusions of the present study are: 1. evidence of the etiology of the pneumonia was established in 86% of 106 young men with pneumonia. pneumococcus was the most common etiologic agent; it was detected definitely in 30% of the pneumonia patients, and possibly in another 20%, by blood culture, sputum culture, antigen detection, and serological methods. 2. pneumococcal antigen detection from purulent pretreatment sputum samples was the best rapid diagnostic method for pne ... | 1988 | 3187395 |
| serum adenosine deaminase activity with mycoplasma pneumoniae. | | 1988 | 3191780 |
| [epidemic occurrence of pneumonia caused by mycoplasma pneumoniae in children]. | | 1988 | 3210550 |
| mri appearances of the cns manifestations of mycoplasma pneumoniae: a report of two cases. | two patients are reported with mycoplasma pneumoniae-related cervical myelitis. magnetic resonance imaging in each case demonstrated clinically silent lesions suggesting more extensive neurological involvement. this supports the concept of widespread immunologically mediated disease occurring as a remote effect of initial m. pneumoniae respiratory infection. differences from the mri appearances of a patient with mycoplasma-related guillian-barré syndrome imply that more than one antigenic determ ... | 1988 | 3221251 |
| [studies on plasma levels and clinical efficacy of rokitamycin in pediatrics]. | pharmacokinetic and clinical evaluations of rokitamycin (rkm, tms-19-q), a new macrolide antibiotic, were carried out. rkm was administered orally to 14 patients with congenital heart diseases before cardiocatheterization and angiography. peak plasma levels of rkm were observed at 30 minutes after the administration at dosages of 5, 10, 15 mg/kg. although the reason is not clear, there were great variations among plasma levels. peak plasma levels of patients with relatively good absorption were ... | 1988 | 3221436 |
| host reactions to mycoplasma pneumoniae infections in guinea-pigs preimmunized systemically with the adhesin of this pathogen. | guinea-pigs developed systemic and local humoral responses after intraperitoneal immunization with the isolated adhesin (168 kda protein) of mycoplasma pneumoniae cells. hilar lymphocytes of these animals showed proliferation after in vitro stimulation with the 168 kda protein or sonicated m. pneumoniae whole cell antigen. animals preimmunized and subsequently infected with m. pneumoniae showed increased m. pneumoniae-specific igg, iga and adherence inhibiting antibody activities. nevertheless t ... | 1988 | 3237055 |
| [epidemiology of pneumonia caused by mycoplasma pneumoniae in children]. | | 1988 | 3237524 |
| [neurologic manifestations caused by mycoplasma pneumoniae. presentation of 4 cases]. | | 1987 | 3274126 |
| autoantibodies to the mitotic spindle apparatus in mycoplasma pneumoniae disease. | antibodies to the mitotic spindle apparatus (ms) have been detected in only a very few patient sera studied for antinuclear antibodies by routine screening (g. a. mccarty, d. w. velencia, and m. j. fritzler, j. rheumatol. 11:213-218, 1984). we found anti-ms antibodies to be quite common in sera from patients with mycoplasma pneumoniae, especially in those who developed cold agglutinins (71%). absorption experiments indicated that the formation of anti-ms antibodies is not triggered by epitopes o ... | 1988 | 3277919 |
| prophylactic treatment of chronic bronchitis. | exacerbations of chronic bronchitis may be caused by a variety of bacterial and viral agents. there is ample documentation of a role for hemophilus influenza, streptococcus pneumonia, mycoplasma pneumoniae, influenza a and b viruses, and several other respiratory viruses in causing these exacerbations. because of the lack of frequency of exacerbations (once every 20 to 78 weeks) and the wide range of pathogens, trials of prophylaxis with antibiotics have been difficult to conduct. controlled tri ... | 1988 | 3283884 |
| [cold agglutinin disease]. | cold agglutinin disease is a normo- or macrocytic anemia due to antibodies, active under body temperature, mostly belonging to the immunoglobulin class m. initially the agglutination of erythrocytes with acrocyanosis is reversible at body temperature. high antibody activity or long lasting period of coldness lead to intravascular or intrahepatic hemolysis, but high risk anemia is rare. beside the idiopathic form, infection induced (especially infectious mononucleosis, cytomegalovirus, mycoplasma ... | 1988 | 3286990 |
| [pneumonia caused by mycoplasma pneumoniae]. | | 1988 | 3290782 |
| the detection of measles specific immunoglobulin m antibodies using biotinylated antigens. | the methods of reverse type enzymeimmunoassay (eias) with biotinylated antigens were used to determine igm antibodies to measles virus in human sera. these antigens, either purified measles virus antigen or lysate type measles-vero antigen with lysate vero control antigen, were used in the two separate igm-tests. paired sera from 15 measles patients as well as 456 sera from patients with viral infections other than measles, with mycoplasma pneumoniae infections, from rheumatoid arthritis patient ... | 1988 | 3293626 |
| aetiology of acute pharyngitis and clinical response to empirical therapy with erythromycin versus amoxicillin. | one hundred and eighty-nine adults with acute pharyngitis had culture and serological evaluation for group a beta haemolytic streptococci (gabhs), mycoplasma pneumoniae, and branhamella catarrhalis. sixteen patients had evidence for infection with gabhs, none for m. pneumoniae, and one for b. catarrhalis. for those with gabhs, there was no significant difference between empirical treatment by erythromycin or amoxicillin. for those without gabhs, empirical treatment with erythromycin appeared to ... | 1988 | 3294074 |
| dna probes for detection and identification of mycoplasmas (mollicutes). | dna probes are expected to prove a specific, sensitive, rapid and inexpensive means for diagnosis of mycoplasma infections, replacing procedures that depend on cultivation of the fastidious organisms. probes made up of conserved genes, such as rrna genes, do offer the advantage of identifying and distinguishing multiple species with a single labeled reagent. the mycoplasmal rrna gene probe pmc5 was effective in detection and identification of mycoplasmas infecting cell cultures. however, use of ... | 1987 | 3312110 |
| identification and isolation of mycoplasmas by immunobinding. | this laboratory has developed an immunobinding assay (iba) to identify and detect mycoplasmas in a variety of specimens. the specimen is inoculated in volumes of 10 microliters onto nitrocellulose (nc) paper, which is then blocked, fixed, and incubated at room temperature. specific antimycoplasma polyclonal or monoclonal antibody is first added, followed by peroxidase-labeled antibody directed toward the first immunoglobulin. alternately, antimycoplasma igg can be purified and conjugated to hors ... | 1987 | 3312111 |
| significance of carbohydrate components of cell surfaces. | this article is focused on a family of carbohydrate structures which are (a) target antigens of autoantibodies and (b) onco-developmental antigens which change during embryonic development, cell differentiation, maturation and oncogenesis. among the carrier molecules of these saccharide structures is the receptor for epidermal growth factor. perturbation of these structures on the isolated receptor enhances autophosphorylation of the receptor glycoprotein. this suggests that the carbohydrate cha ... | 1987 | 3315506 |
| treatment of respiratory tract infections with cephalosporin antibiotics. | infections of the respiratory tract are among the most common causes for antibiotic prescribing. their diagnosis within the community is generally limited to clinical criteria, and microbiological information is frequently lacking. hospitalised patients with respiratory tract infections are more likely to undergo diagnostic sampling, but difficulties remain in reliably defining a microbial aetiology, thereby providing a confident basis for antibiotic selection. in considering the role of the cep ... | 1987 | 3319501 |
| evaluation of a microhaemagglutination test for the serological diagnosis of mycoplasma pneumoniae infections. | | 1987 | 3330747 |
| post-infectious leukoencephalopathy as a complication of mycoplasma pneumoniae infection. | we report a 9-year-old girl with leukoencephalopathy who demonstrated serologic evidence of a mycoplasma pneumoniae infection. she had a mild upper respiratory tract illness 10 days prior to admission and developed walking difficulty and somnolence. the neurologic symptoms progressed to semicoma and spastic paraplegia over a few days but began to improve on the fourth day. cranial computed tomography on the eleventh day revealed an area of diffuse low density in the white matter. cerebrospinal f ... | 1987 | 3334013 |
| [encephalitis in mycoplasma pneumoniae infections]. | | 1988 | 3340249 |
| epidemiology of acute respiratory illness during an influenza outbreak in a nursing home. a prospective study. | we observed an influenza epidemic caused by influenza a/arizona/82 (h3n2) in a nursing home during 1982 to 1983. a survey indicated that 59% of the residents were immunized before the outbreak. the outbreak was observed to begin in november, peak in february, and disappear in april. a significant level of herd immunity may have accounted for the slow progression through the nursing home. in addition, serologic evidence of concurrent infection with respiratory syncytial virus, parainfluenza virus ... | 1988 | 3341856 |
| an outbreak of mycoplasma pneumoniae pneumonia in two kibbutzim: a clinical and epidemiologic study. | during a period a 9 months, 125 individuals with pneumonia due to infection with mycoplasma pneumoniae were identified among 1,242 individuals in two israeli kibbutzim. the monthly incidence of m. pneumoniae pneumonia (mpp) was 13.3/1,000 population. of those infected, 93 (74.4%) were under the age of 18 years. the clinical course of mpp was mostly benign. the prominent signs and symptoms of disease were cough (100%), fine respiratory crepitations (77%), fever (37%), and diminished breathing sou ... | 1988 | 3356539 |
| [neurologic manifestations of mycoplasma pneumoniae]. | | 1988 | 3368602 |
| distinction of species and strains of mycoplasmas (mollicutes) by genomic dna fingerprints with an rrna gene probe. | genomic fingerprints of acholeplasma laidlawii, mycoplasma hominis, and mycoplasma pneumoniae strains were obtained by southern blot hybridization of the digested mycoplasmal dnas with an rrna gene probe. the hybridization patterns revealed genotypic heterogeneity among a. laidlawii and m. hominis strains and a remarkable degree of homogeneity among m. pneumoniae strains isolated from pneumonia patients during a 10-year period. genomic fingerprints with the rrna gene probe can thus serve as indi ... | 1988 | 3384931 |
| [the role of mycoplasma pneumoniae in acute pneumopathies in children]. | among 199 cases of bronchopulmonary infection in children observed over a 2-year period, 22 cases (11%) were due to mycoplasma pneumoniae. the diagnosis was based upon the complement fixation test on whole serum in half of the children and the research of specific igm by complement fixation test on fractioned serum and/or indirect immunofluorescence on the others. the mean age of children with mycoplasma pneumoniae was 6 years. the clinical and radiographic appearance of the affection was non sp ... | 1988 | 3393411 |
| mycoplasma pneumoniae infection associated with henoch-schonlein purpura. | | 1988 | 3397582 |
| bacteremic pneumococcal pneumonia in sweden: clinical course and outcome and comparison with non-bacteremic pneumococcal and mycoplasmal pneumonias. | 279 patients with 285 episodes of bacteremic pneumococcal pneumonia (pnb), treated at the 2 departments for infectious diseases in stockholm, sweden, were reviewed retrospectively. almost half of all episodes were caused by serotypes 3, 9 and 4 (in that order). the overall mortality rate was 7% and as low as 5% if patients with extrapulmonary complications were excluded. as in other studies male sex, alcoholism and absence of leukocytosis on admission to hospital were all associated with a highe ... | 1988 | 3399836 |
| igg response to mycoplasma pneumoniae in patients with community-acquired pneumonia determined by elisa. | in a prospective study of community-acquired, radiologically verified pneumonia, a solubilized mycoplasma antigen was used in an enzyme-linked immunosorbent assay (elisa) for the detection of igg-antibodies to mycoplasma pneumoniae in paired sera from 60 patients. all of the 13 patients with a positive complement fixation (cf) test for m. pneumoniae were positive in the elisa, and 46 out of 47 patients with a negative cf test were negative. the only false positive test was recorded from a patien ... | 1988 | 3408589 |
| many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence galnac beta 1-4gal found in some glycolipids. | pneumonia is one of the most common causes of death from infectious disease in the united states. to examine the possible role of carbohydrates as adhesion receptors for infection, several pulmonary pathogenic bacteria were studied for binding to glycosphingolipids. radiolabeled bacteria were layered on thin-layer chromatograms of separated glycosphingolipids, and bound bacteria were detected by autoradiography. the classic triad of infectious bacteria found in cystic fibrosis, pseudomonas aerug ... | 1988 | 3413084 |
| antibodies in the sera of mycoplasma pneumoniae-infected patients against proteins of mycoplasma genitalium and other mycoplasmas of man. | frequency and pattern of anti-mycoplasma genitalium antibodies in sera of 50 patients with mycoplasma pneumoniae-infection were examined by the western immunoblot method. the sera reacted with several proteins of m. genitalium. however, during the course of infection there was only a moderate increase of antibodies mainly against the bands of 135 and 105 kd in contrast to the more intense increase of numerous bands of m. pneumoniae. if antibodies against the 168 kd-adhesin of m. pneumoniae were ... | 1987 | 3425034 |
| activity of macrolides against organisms responsible for respiratory infection with emphasis on mycoplasma and legionella. | the activity of roxithromycin against legionella pneumophila in vitro was approximately the same as that of rokitamycin and superior to those of erythromycin and josamycin. in experimental pneumonia due to l. pneumophila none of the animals in the roxithromycin and rifampicin groups died by day 10 of the infection. the mic ranges of roxithromycin, erythromycin and rokitamycin for mycoplasma pneumoniae were 0.008-0.063, 0.004-0.008 and 0.016-greater than 125, respectively. in experimental pneumon ... | 1987 | 3429389 |
| [disseminated invasive aspergillosis associated with mycoplasma pneumoniae infection]. | disseminated aspergillosis is rare in patients not suffering from haematological disorders and myelo-suppression. we report a case of pulmonary cardiac and renal aspergillosis diagnosed at autopsy in a patient with chronic respiratory failure dying in the intensive care unit during an acute exacerbation. the role of risk factors associated with invasive aspergillosis in patients not suffering from myelosuppression is discussed (steroid therapy, chronic respiratory disease, concomitant viral or b ... | 1987 | 3432718 |
| demonstration of cross-reactive antibodies to mycoplasmas in human sera by elisa and immunoblotting. | varying levels of cross-reactivity to some mycoplasma species were observed in the sera of patients infected with mycoplasma pneumoniae and even in normal human sera by enzyme-linked immunosorbent assay (elisa). the absorption of the patients' sera with m. pneumoniae lysate showed the decrease in elisa titers not only to m. pneumoniae, but also to other mycoplasma species. these results suggested the existence of cross-reactive antibodies to mycoplasmas in human sera. cross-reactive antibodies t ... | 1987 | 3437828 |
| [pneumonia caused by mycoplasma pneumoniae in children]. | | 1987 | 3442012 |
| serological testing of human blood samples for infectious diseases in the abeokuta and the minna hospitals/nigeria. | in serological investigations undertaken in two hospitals in nigeria a total of 188 blood samples were examined and the following positive reactions for various diseases found: malaria 100%, leishmaniasis 9.5%, biharziasis 2.1%, yersinia 16.4%, legionella pn. 9%, gonorrhea 6%, syphilis 6.9%, measles 65.4%, rubella 84%, cytomegalic 78.2%, herpes simplex 67%, varicella 30.8%, resp. sync. virus 34.6%, influenza a 57.4%, influenza b 73.9%, para-influenza 1, 2, 3, 20.7%, 16.5%, 52.6%, adenovirus 25%, ... | 1987 | 3443750 |
| thrombocytopenia and fatal intracerebral hemorrhage associated with mycoplasma pneumoniae pneumonia. | | 1986 | 3467231 |
| penetration of ofloxacin into bronchial secretions. | the penetration of ofloxacin into bronchial secretions was evaluated in 16 patients after administration of a single oral dose of ofloxacin 400mg. bronchial secretions were aspirated at bronchoscopy after 1 to 6 hours and serum was collected simultaneously. ofloxacin concentrations were measured by a microbiological assay method. considerable individual variations in serum and bronchial aspirate concentrations were recorded: bronchial aspirate concentrations varied between 1.1 mg/l and 4.5 mg/l ... | 1987 | 3481325 |
| [analysis of lymphocyte subsets in peripheral blood and bronchoalveolar lavage fluid in patients with pneumonia due to mycoplasma pneumoniae]. | | 1986 | 3488460 |
| in-vitro activity of roxithromycin against respiratory and skin pathogens. | the activity of roxithromycin was determined by a microdilution method, in comparison with erythromycin, spiramycin and josamycin. roxithromycin and erythromycin showed very similar mics against staphylococci, streptococcus pneumoniae, str. pyogenes and haemophilus influenzae. in most cases, spiramycin and josamycin appeared similarly or more active. the activity of roxithromycin against mycoplasma pneumoniae, legionella spp., chlamydia psittaci and, to some extent, against pasteurella spp. was ... | 1987 | 3501424 |
| total and specific ige responses in the acute and recovery phases of respiratory infections in children. | total ige and specific ige antibodies to common allergens were determined by the enzyme-linked immunosorbent assay in children with mycoplasma pneumoniae or respiratory syncytial virus (rsv) infections. the decrease of total ige from the acute to convalescent phase was observed in 105 of 134 (78.4%) children with m. pneumoniae infection and in 40 of 49 (81.6%) of those with rsv infection. similarly, many patients showed a decrease of the responses of specific ige in the convalescent phase of the ... | 1987 | 3505529 |
| [sero-epidemiological studies on mycoplasma pneumoniae infections in pneumonia in children]. | | 1986 | 3527438 |
| [incidence of mycoplasma pneumoniae infection in a population of hospitalized patients during an epidemic]. | during an outbreak with mycoplasma pneumoniae, a serological survey was performed with 3,165 sera from 1,900 hospitalized patients over a 33 months period. four hundred and eleven patients exhibit serological pattern suggestive for a recent infection. the main points are the following: the infection was more frequently (21.6%) detected in females than males, in the patients 5 to 19 years than in the other age groups; the incidence of the infection is the same in the group of patients hospitalize ... | 1986 | 3528997 |
| prevalence of legionnaires' disease in pneumonia patients admitted to a danish department of infectious diseases. | during a 14-month study period, 92 patients admitted to the university clinic for infectious diseases with pneumonia were investigated to determine the prevalence and severity of legionnaires' disease (ld). the diagnosis of ld was based on positive serology. antibodies to 10 different legionella antigens--legionella pneumophila serogroups 1-6, fluoribacter (legionella) bozemanae, f. dumoffii, f. gormanii, and tatlockia (legionella) micdadei--were measured by the microagglutination (ma) and indir ... | 1986 | 3532303 |
| viral and bacterial organisms associated with acute pharyngitis in a school-aged population. | to investigate the causes and clinical characteristics of acute pharyngitis among school-aged children (4 to 18 years), we obtained throat cultures for respiratory viruses, mycoplasma pneumoniae, group a streptococcus, and chlamydia trachomatis from 320 patients with sore throat and 308 controls without respiratory complaints. the study was conducted from january to april 1985 in a private pediatric practice in central new york state. sixty percent of the patients and 26% of the control subjects ... | 1986 | 3534196 |
| [stevens-johnson syndrome associated with mycoplasma pneumoniae infection. apropos of a pediatric case]. | a 13 years old girl presented an acute episode of fever, productive cough, purulent rhinorrhea and bilateral pulmonary crepitant rales. 36 hours later a maculopapular eruption appeared on the face, extended to all body and became bullous. pluriorificial mucous membranes lesions were associated (conjunctivae, buccal mucosa, lips, nasal mucosa, genitalia and the perirectal area). parenteral prednisone was administered and the extension of the eruption was stopped in a few hours. lesions healed in ... | 1986 | 3534784 |
| exacerbation of cyclosporine toxicity by concomitant administration of erythromycin. | cyclosporine (csa), an immunosuppressive drug widely used in clinical organ transplantation, causes a variety of side effects, including parenchymal complications of nephrotoxicity and hepatotoxicity. erythromycin ethinylsuccinate (ees), a macrolide antibiotic frequently administered to transplant patients afflicted with pneumonias caused by mycoplasma pneumoniae and legionella pneumophila, markedly potentiated parenchymal drug toxicity in nine (three renal and six cardiac) csa-treated allograft ... | 1987 | 3544386 |
| [mycoplasma etiology of acute pancreatitis]. | in a 10 year-old girl the clinical and laboratory findings led to the diagnosis of pancreatitis. at the same time an infection by mycoplasma pneumoniae was serologically stated. since there could not be found another cause for pancreatitis, a relation between pancreatitis and infection by mycoplasms is very probable. | 1986 | 3548105 |