| diagnosis and management of atypical mycobacterial lymphadenitis in children. | one hundred and thirty children with superficial atypical mycobacterial lymphadenitis have been treated between 1958 and 1974. the introduction of double mantoux testing has provided a reliable means of differentiating human and bovine from atypical infection and has enabled us to cease the routine use of antituberculous drugs. adequate local surgical excision has become the treatment of choice. | 1976 | 812977 |
| primary tuberculous complex of the skin. | | 1976 | 813020 |
| [studies on indication of surgical treatment for open negative cases based on findings of tubercle bacilli cultivated from resected cavities (author's transl)]. | | 1975 | 813046 |
| [inoculation frequency of tuberculosis mycobacteria in patients with various lung diseases]. | | 1975 | 813092 |
| review of tuberculosis among the orang asli (aborigines) in west malaysia from 1951-1970. | | 1975 | 813093 |
| synthesis of some 2-aminonicotinic acid derivatives. | the nucleophilic exchange of chlorine atom in 2-chloro-3-cyanopyridine with morpholine, piperidine and pyrrolidine was carried out. acids, amides, thioamides, esters and hydrazides were derived from the obtained compounds (fig. 1). some of these compounds showed only moderate tuberculostatic activity. | 1975 | 813189 |
| [typing of mycobacterium tuberculosis with the aid of phages and other methods]. | | 1975 | 813213 |
| [determination of the activity of pulmonary tuberculosis]. | | 1975 | 813214 |
| [efficacy of fluorescence microscopy in the detection of acidoresistant bacilli from the sputum]. | | 1975 | 813254 |
| [effect of the nature of the bacillus elimination on the healing of destructive pulmonary tuberculosis]. | | 1976 | 813391 |
| [supplement to the 1972 recommendations for the therapy of respiratory tract tuberculosis]. | | 1975 | 813405 |
| [pathogenesis of certain mycobacterioses in a chemically damaged liver of the rabbit (author's transl)]. | cirrhosis of the liver was provoked in adult rabbits by the administration of ccl4/0,3 ml subcutaneously two times a week during a period of six weeks. it was found that the infection by m. tuberculosis, m. avium and m. kansasii causes a considerably greater dissemination than in the case with the livers of rabbits unaffected by cirrhosis, and that even a non-pathogenic strain (m. intracellulare) is pathogenic, if the liver is affected. our findings confirm the lowered resistance of a chemically ... | 1975 | 813406 |
| [study of rifampicin in the treatment of tuberculosis and nonspecific inflammatory lung diseases]. | benemecin, a polish rifampicin was tested in vitro and clinically for the treatment of 2 groups of patients, i.e. 28 patients with chronic destructive tuberculosis of the lungs and 30 patients with non-specific pneumonia. high tuberculostatic activity of the drug in vitro was found. the clinical trials showed high efficiency of benemecin in the treatment of chronic destructive tuberculosis of the lungs and pneumonia of non-specific etiology. the drug was mainly well tolerated by the patients. | 1975 | 813565 |
| isolation, characterization, and function of 6-mycolyl-6'-acetyltrehalose in the h37ra strain of myocobacterium tuberculosis. | the major mycolic acid containing extractable lipid of the h37ra strain of mycobacterium tuberculosis was established to be 6-mycolyl-6'-acetyltrehalose (mat). this new glycolipid was extracted from harvested cells with chloroform-methanol (2:1, v/v) and initially precipitated out in acetone. a series of column (deae-cellulose, silicic acid, and sephadex lh-20) and preparative thin-layer chromatography steps yielded a homogeneous preparation. a single sugar was released by saponification and it ... | 1976 | 813763 |
| immune-mediated demyelination in the rabbit retina after intraocular injection of antigen. | | 1976 | 813819 |
| effect of rifampin on immunity to tuberculosis and on delayed hypersensitivity to purified protein derivative. | mice vaccinated with mycobacterial ribonucleic acid (rna) produced a high immune response and did not develop delayed hypersensitivity to purified protein derivative (ppd), and rifampin had no effect on the immune response. mice vaccinated with viable h37ra cells produced a high immune response and did develop delayed hypersensitivity to ppd. rifampin had no effect on this immune response, but reduced the footpad reactions to ppd. both mycobacterial rna and poly(a:u) served as adjuvants for indu ... | 1976 | 814098 |
| diagnostic standards of tuberculosis--revised. | | 1976 | 814255 |
| [the 50th annual meeting symposium. i. immunological activity of mycobacteria (author's transl)]. | | 1975 | 814362 |
| reappraisal of the activity of morphazinamide against m. tuberculosis. | morphazinamide was shown to have an in vitro activity similar to an equimolar concentration of pyrazinamide. this activity was not due, as had been previously assumed, to pyrazinamide formed by hydrolysis from morphazinamide, since it was demonstrated in slide cultures containing tubercle bacilli which were incubated with freshly prepared dilutions of morphazinamide in acid medium for several successive periods of only 1 hour, during which time little hydrolysis occurred. a new method was used f ... | 1975 | 814663 |
| notes on the organization of tuberculosis bacteriology and its quality control. | the time-scale of tuberculosis allows the centralization of identification and sensitivity tests on positive cultures with the advantages of better efficiency, economy and safety. the system operated in england and wales is described with its methods of quality control. the incidence of false resistance in new cases is less than 0-1 per cent and that of missed resistance little more. arguments are advanced against the use of blind chemotherapy on new patients in britain. | 1975 | 814664 |
| the genetics of mycobacteria and mycobacteriophages - a review. | the genus mycobacterium, despite its medical importance, has so far received relatively little attention from bacterial geneticists. nevertheless examples of the transfer of genes from one strain to another by means of transformation, phage-mediated transduction and direct cellular contact have been reported. the modification of strains by experimental or naturally occurring lysogeny has been studied in some detail and there is evidence that phage may contribute significantly to variation within ... | 1975 | 814665 |
| [eliminating the tuberculosis bacillus from camel's milk and hair]. | | 1975 | 814690 |
| [transfer to the leukocytes of neonates by means of the plasma of patients with tuberculosis and of healthy persons of the ability to depress migration under the influence of antigens of mycobacterium tuberculosis in vitro]. | a study was made of the effect of the blood plasma of patients suffering from tuberculosis and of healthy individuals on the in vitro migration in the presence of old tuberculin and the bcg vaccine of the leukocytes of neonates sensitive and insensitive to these antigens. plasma of tuberculosis patients and more rarely of healthy persons created favourable conditions for depression of migration with old tuberculin and the bcg vaccine of the neonatal leukocytes insensitive to it on autoplasma, i. ... | 1975 | 814751 |
| multiplication of mycobacterium tuberculosis and mycobacterium bovis in microtus agrestis (field vole). | the multiplication of bacteria is examined by quantitative culture from the organs of two groups of field voles injected intraperitoneally with a large dose of m. tuberculosis or a small dose of m. bovis and killed at intervals during a period of up to 3 months after the injection. m. tuberculosis given in a dose of 7 x 10(5) viable units did not multiply, or multiplied only to a small extent. none of the animals in the group died from tuberculosis and the macroscopical lesions found at autopsy ... | 1976 | 814785 |
| [antitubercular agents. xvi. use of hmo computations in the study of structure-activity relationship of antitubercular agents. iii]. | | 1975 | 815004 |
| fructose-1,6-diphosphate aldolase of mycobacterium tuberculosis h37rv. | | 1975 | 815159 |
| gas chromatographic characterization of mycobacteria: analysis of fatty acids and trifluoroacetylated whole-cell methanolysates. | mycobacterium avium, m. bovis strain bacillus calmette-guerin (bcg), m. kansasii, and m. tuberculosis were studied by gas-liquid chromatography. methylated fatty acids of the mycobacterial lipids and trifluoroacetyl (tfa) derivatives of whole-cell methanolysates were analyzed. both the fatty acid and the tfa chromatograms showed reproducible differences between the various mycobacteria studied. chromatograms from different strains of one and the same species showed negligible differences. fatty ... | 1976 | 815272 |
| [morphology and structure of mycobacterium tuberculosis]. | | 1975 | 815688 |
| [mode of growth of mycobacterium tuberculosis]. | | 1975 | 815689 |
| [genetic study of mycobacterium tuberculosis]. | | 1975 | 815690 |
| [metabolism of mycobacterium tuberculosis]. | | 1975 | 815691 |
| [drug resistance of mycobacterium tuberculosis]. | | 1975 | 815692 |
| [chemistry and biological activities of the components of mycobacterium tuberculosis]. | | 1975 | 815693 |
| [tuberculin protein]. | | 1975 | 815694 |
| [polysaccharides of mycobacterium tuberculosis]. | | 1975 | 815695 |
| [glycolipids of mycobacterium tuberculosis]. | | 1975 | 815696 |
| [phospholipids]. | | 1975 | 815697 |
| [cord factor]. | | 1975 | 815698 |
| [wax d]. | | 1975 | 815699 |
| [experimental tuberculosis]. | | 1975 | 815700 |
| [experimental lung cavity]. | | 1975 | 815701 |
| [host-parasite relationship in the transmission of tuberculosis]. | | 1975 | 815702 |
| [antimycobacterial immunity]. | | 1975 | 815703 |
| [culture media and colony formation of mycobacterium tuberculosis]. | | 1975 | 815704 |
| [microbial sensitivity tests for mycobacterium tuberculosis]. | | 1975 | 815705 |
| [primary drug resistance]. | | 1975 | 815706 |
| [a study of prevalence of resistance to major drugs among newly admitted pulmonary tuberculosis patients in 1972. part 2. studies on the factors related to the prevalence of drug resistance (author's transl)]. | | 1975 | 815707 |
| [the clinical significance of the critical drug concentration of rifampicin. report 1. studies on the mic of rifampicin to tubercle bacilli isolated from the rifampicin untreated patients using 1% ogawa medium (author's transl)]. | | 1976 | 815708 |
| [a study of the ph phage susceptibility of m. tuberculosis isolated from tuberculosis patients (author's transl)]. | | 1976 | 815709 |
| [the clinical significance of the critical drug concentration of rifampicin. report 2. clinical investigation: the emergence and reversion of resistance (author's transl)]. | | 1976 | 815710 |
| [clinico-bacteriological parallels in patients operated on for fibrous-cavernous pulmonary tuberculosis]. | | 1975 | 815903 |
| [primary drug resistance of mycobacterium tuberculosis to antitubercular drugs and its clinical significance]. | | 1975 | 815904 |
| [primary drug resistance of mycobacterium tuberculosis in patients with coniotuberculosis]. | | 1975 | 815905 |
| improvements for consistently inducing experimental allergic encephalomyelitis (eae) in rats: i. without using mycobacterium. ii. inoculating encephalitogen into the ear. | several methods of inducing experimental allergic encephalomyelitis (eae) in rats were examined using different (i) rat strains, (ii) combinations of encephalitogen with different adjuvants, and (iii) sites of encephalitogen inoculation. the time course and severity of the ensuing diseases were determined and methods delineated for inducing a disease with limited variability and high incidence. omitting the mycobacterial component from the adjuvant eliminated the complication of adjuvant arthrit ... | 1976 | 815915 |
| specific acquired resistance and activity of migration inhibition factor (mif) in spleens of mice with chronic tuberculosis. | the antimycobacterial resistance of the host (as evaluated by mycobacterial counts in spleens) and the in vitro cell-mediated immunological mechanisms ((cellular immune reactivity) assayed by the activity of migration inhibition factor in splenic fragments) were compared in the course of experimental chronic tuberculosis infection. mice, either unvaccinated or vaccinated with killed mycobacteria suspended in saline and then either untreated or treated with azathioprine, were used in the study. t ... | 1975 | 816003 |
| miliary tuberculosis following homograft valve replacement. | postoperative septicaemia with infective endocarditis is a recognized complication of open-heart surgery, in particular homograft or prosthetic replacement of cardiac valves. several infective organisms, both bacterial and fungal, have been incriminated but infection due to tubercle bacilli has not, to our knowledge, been reported. the clinicopathological features of this condition are discussed. during a five-year period, over 800 homograft replacements in the aortic and/or mitral positions hav ... | 1976 | 816028 |
| practical application of bovine tuberculin ppd in testing cattle in great britain. | a national tuberculin testing trial was carried out in 8151 cattle in 132 herds due for normal herd testing and distributed throughout the 11 animal health administrative regions of england, scotland and wales. the numbers selected from each region were in approximately equal proportions to the total cattle populations of the regions and comprised a representative sample of the national herd. the standard intradermal comparative tuberculin test using weybridge avian and human purified protein de ... | 1976 | 816049 |
| presence of antibodies reacting with a ribonucleoprotein from mycobacterium tuberculosis in sera from leprous patients. | antibodies reacting with a ribonucleoprotein isolated from m. tuberculosis could be found in sera of leprous patients (lepromatous type of disease). the antibody titers are very high. there is a highly significant difference between the titers of leprous patient and tuberculosis patients. this renders our finding important for diagnostic purpose. | 1976 | 816112 |
| [tuberculocidal activity of lithium hydrochloride, the potassium salt of dichlorisocyanuric acid and sulfochloranthine]. | | 1975 | 816121 |
| liquefaction of caseous foci in tuberculosis. | | 1976 | 816235 |
| distribution of mycobacteria grown in vivo in the organs of intravenously infected mice. | suspensions of 35-day-old mycobacterium tuberculosis h37rv prepared from stirred liquid cultures and injected intravenously into cd-1 mice accumulated in the lungs at a significantly higher concentration that that seen with logarithmically growing cells. mice were infected with logarithmic 8-day-old or stationary phase 35-day-old suspensions of h37rv, and 24 hours later, the bacilli within pooled lung and splenic homogenates were recovered by differential centrifugation. the bacilli were then ho ... | 1976 | 816236 |
| mutational studies of the drug-resistance of m. tuberculosis with special reference to p-aminosalicylic acid, ethambutol, isoniazid and rifampicin. | in the m. tuberculosis h37rv and in the human tubercular strains isolated from patients, the localization of genetic determinants of drug-resistance to antitubercular chemotherapeutic drugs in current use was studied. data obtained through the treatment of the resistanct strains with acridine dyes and ethidium bromide, and the analysis of irreversible elimination of resistance markers support the hypothesis of an extrachromosomal locus for the p-aminosalicylic acid (pas)-resistance and confirm a ... | 1975 | 816363 |
| the non-passage of mycobacteria from freund's complete adjuvant granuloma depots to arthritic joints. | the intra-articular injection of antigen after immunization with that antigen in fca, the mycobacterial component of which consisted of live m. avium or dead 125i-m. tuberculosis, resulted in identical chronic disease, experimental allergic arthritis. in the former case live mycobacteria could be isolated from the subcutaneous granuloma which developed at the injection site, and from arthritic joints into which 10 mug wet weight (equivalent of 2 mug dry weight) had been injected with this antige ... | 1975 | 816368 |
| purification and properties of dna-dependent rna polymerase from mycobacterium tuberculosis h37rv. | rna polymerase (nucleosidetriphosphate: rna nucleotidyltransferase dna-dependent), ec 2.7.7.6) was purified approximately 200 fold from mycobacterium tuberculosis h37rv cells. the purified enzyme has a molecular weight of about 330 000-350 000 and is composed of four subunits. the subunits beta', beta and sigma have molecular weights different from those of escherichia coli polymerase; the fourth, alpha subunit has a similar weight. the purified enzyme is a thousand-fold more sensitive to rifamp ... | 1976 | 816387 |
| [reactivity of the neuroglia in guinea pigs sensitized with mycobacteria tuberculosis]. | the changes in the glial cell reactivity depended on the phase and severity of the pathological process in the experimental allergic encephalomyelitis induced in guinea pigs by injection of mycobacteria tuberculosis in a mixture of arlacel and vaselin. these reactivity changes measured by the method of inhibition of the glial cell migration in the tissue culture was specific of the nervous tissue antigens. the same changes in the reactivity could be induced in the tissue culture of the glial cel ... | 1975 | 816399 |
| [influence of various combinations of antitubercular agents on the course of experimental tuberculous infections and development of drug resistance]. | | 1975 | 816709 |
| separation of an adjuvant-active glycolipid lacking peptide moiety from wax d preparation of mycobacterium tuberculosis strain aoyama b. | | 1976 | 816734 |
| comparison of antigens in sonic and pressure cell extracts of mycobacterium tuberculosis. | comparisons were made of the yield, chemical content, and biological activity of filtrates and extracts obtained by sonic and pressure cell disruption of bacilli from 4- and 8-week-old proskauer and beck cultures of the h37rv strain (tmc no. 102) of mycobacterium tuberculosis. the culture filtrates were dialyzed, freeze-dried, reconstituted in saline, and sterilized by membrane filtration. the viable bacilli were washed and resuspended in distilled water and subsequently disrupted either by soni ... | 1976 | 816743 |
| immune response of guinea pigs with deal's sarcoma to different strains of mycobacteria. | | 1976 | 816967 |
| mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type. | quantitative structure-activity studies have been performed for a series of 2-substituted isonicotinic acid hydrazides by correlating electronic, steric, and lipophilic properties of the substituents with the biological activity date (mic) from serial dilution tests with mycobacterium tuberculosis (strain h 37 rv). the reaction rates for the quaternization of 2-substituted pyridines with methyl iodide were also determined. the rate constants show a similar dependence on the steric and electronic ... | 1976 | 817022 |
| tuberculosis of the tongue. | | 1976 | 817039 |
| a comparison of several intradermal tuberculins in macaca mulatta during an epizootic of tuberculosis. | during an epizootic of tuberculosis in rhesus monkeys, several intradermal test reagents were compared for accuracy in detecting tuberculosis and for strength of reaction elicited. a purified protein derivative of mycobacterium bovis, similar to one which will probably be approved for official veterinary testing and thus eliminate tuberculin-mammalian intradermic from commercial production, was among those evaluated. none of the reagents was found to be superior to tuberculin-mammalian intraderm ... | 1976 | 817080 |
| experimental studies on the etiology of pulmonary cancer. | | 1975 | 817115 |
| investigations of pyrazine derivatives. part iv. synthesis and tuberculostatic activity of some 6-alkoxypyrazine-2-carboxylic acids. | by alcoholysis of 2-cyjano-6-chloropyrazine corresponding 6-alkoxypyrazine-2-imidoesters (1,6,11,16) were formed, which were then transformed in esters and amides of 6-alkoxypyrazine-2-carboxylic acids. some of these compounds show a weak tuberculostatic activity. | 1976 | 817274 |
| [clinico-morphologic and bacteriologic correlations in children and adolescents operated on for tuberculosis of the respiratory organs]. | | 1976 | 817282 |
| [intermittent chemotherapy of chronic forms of pulmonary tuberculosis]. | | 1976 | 817283 |
| [determination of the activity of recently diagnosed mild forms of pulmonary tuberculosis in adults]. | | 1976 | 817284 |
| ultraviolet susceptibility of bcg and virulent tubercle bacilli. | to test the effectiveness of irradiating the upper air of a room with ultraviolet light at reducing the concentration of airborne tubercle bacilli, the susceptibility to the germicidal effects of ultraviolet light, z, was determined for various mycobacteria. virulent tubercle bacilli and bacille calmette-guérin (bcg) were equally susceptible to ultraviolet radiation, whereas mycobacterium phlei had 10 times their resistance (z, approximately one-tenth that for m. tuberculosis). the effectiveness ... | 1976 | 817628 |
| a continuing survey of primary drug resistance in tuberculosis, 1961 to 1968. a u.s. public health service cooperative study. | from 1961 through 1968 the incidence of primary drug resistance was monitored among patients admitted to 22 participating hospitals. the patients were believed to have newly diagnosed, previously untreated, bacteriologically proved pulmonary tuberculosis. during the study period the level of primary resistance to isoniazid, streptomycin, and para-aminosalicylic acid remained very low; there was no indication that primary resistance to these drugs was increasing. investigation of patient historie ... | 1976 | 817629 |
| computer files and analyses of laboratory data from tuberculosis patients. ii. analyses of six years' data on sputum specimens. | laboratory data on sputum specimens from patients with pulmonary mycobacterioses between 1968 and 1973 were analyzed. specimens were cultured on middlebrook 7h10 and/or 7h11 medium; blue light fluorescence microscopy was used to examine specimen smears. an admission series of 6 sputum specimens detected 94.7 per cent of all culture-positive patients. only 62 per cent of patients who were culture positive in the admission series would have been detected by smear alone. quantitative agreement of s ... | 1976 | 817630 |
| letter: evidence for infection by two distinct strains of myobacterium tuberculosis in pulmonary tuberculosis. | | 1976 | 817631 |
| carbohydrate analysis of concanavalin a-reactive and concanavalin a-nonreactive mycobacterial polysaccharides. | concanavalin a-nonreactive polysaccharide and 2 concanavalin a-reactive polysaccharides of differing concanavalin a affinities that had been purified from culture filtrates of mycobacterium tuberculosis were subjected to carbohydrate analysis by gas and gas-liquid chromatography. concanavalin a-nonreactive polysaccharide was found to be d-arabinogalactan, and the concanavalin a-reactive polysaccharide of highest affinity was found to be d-arabinomannan. the lower affinity concanavalin a-reactive ... | 1976 | 817632 |
| [quantitative evaluation of the effect of depression of mycobacterium tuberculosis intracellular multiplication under the influence of antibacterial preparations]. | the use of the average effective dose (ed50) for estimation of the activity of antitubercle drugs against mycobacteria situated inside the cells is proposed. the dose-effect dependence for rifampicin and cycloserin was found. expedience in the use of the regressive analysis for determination of a number of parameters characterizing qualitatively and quantitatively the effect of the antitubercle drugs on the intracellular multiplication of the bacteria was shown. the programme developed by the au ... | 1975 | 817645 |
| miliary tuberculosis presenting with multifocal oral lesions. | | 1976 | 817774 |
| diagnosis, prevention and early therapy of tuberculosis. | | 1976 | 817877 |
| the differentiation of an adult's bloodstain from that of a child using an indirect fluorescent antibody technique. | a procedure is described for the detection of specific antimicrobial antibodies in bloodstains. the technique is described and the relationship between antibody concentration and the age of the doner is reported. it is shown that, provided foetal blood can be excluded, an unknown bloodstain may be identified as that of a person over 15 years with a high degree of confidence. | 1975 | 817999 |
| cycloserine plus ethionamide plus pyrazinamide in the treatment of patients excreting isoniazid-resistant tubercle bacilli following previous chemotherapy. | | 1976 | 818010 |
| analysis of the cell wall of five strains of myocbacterium tuberculosis bcg and of an attenuated human strain, w 115. | the chemical composition of the deproteinized, delipidated cell walls of five strains of bcg and of an attenuated human strain of mycobacterium tuberculosis has been established, with special focus on their poly-l-glutamic acid content. all the cell walls have the same overall composition. their poly-l-glutamic acid content varies from 0 to 4.6%. a correlation between the poly-l-glutamic acid content and the biological properties of the bcg strains reported in the literature could not be establi ... | 1976 | 818013 |
| adjuvant effect of cord factor, a mycobacterial lipid. | cord factor was a good adjuvant in mice and rats but exerted little if any adjuvant effect in guinea pigs. in rats, cord factor not only enhanced antibody production but also induced delayed hypersensitivity. wax d was a weak adjuvant in mice. cord factor caused a marked inflammatory swelling at the sites of injection in mice, but it caused no such swelling in rats and guinea pigs. | 1976 | 818016 |
| enhancement activity of anti-mycobacterial sera in experimental mycobacterium bovis (bcg) infection in mice. | the passive transfer of rabbit anti-mycobacterial immunoglobulins was directed against either living or soluble extracts of mycobacterium tuberculosis strain h37rv, which promotes the multiplication of the bcg strain of m. tuberculosis in the spleen of mice infected with low doses of this latter strain. this enhancing effect was reduced significantly when antisera were absorbed with living bcg. moreover, such treatment led to the removal of all hemagglutinating antibodies when antisera were test ... | 1976 | 818022 |
| use of phage f-phi wj-1 of mycobacterium fortuitum to discern more phage types of mycobacterium tuberculosis. | a total of 125 strains of mycobacterium tuberculosis from the southeastern area of the united states was subjected to phage typing. in addition to the five major mycobacteriophages, a new phage, f-phi wj-1, was used in the study. the results obtained with the five major phages were: type a0, 35.2%; type b, 29.6%, and type c, 4.0%. the remaining 21.2% of the strains phaged typed as subgroups a1 through a6. these percentages were similar to the typing results of earlier studies. the new phage, f-p ... | 1976 | 818112 |
| quantitative structure-activity relationships. 2. a mixed approach, based on hansch and free-wilson analysis. | based on the theoretical and numerical equivalence of hansch's linear multiple regression model and the modified free-wilson model a mixed approach is developed. the mixed approach is a combination of both models which makes use of the advantages of each model and widens the applicability of hansch and free-wilson analysis. the free-wilson approach now is applicable also in the case of parabolic dependence of biological activity on a particular physical property, e.g., log p or pi. a rational ex ... | 1976 | 818381 |
| [clinical studies on the phosphatide kaolin agglutination test (author's transl)]. | | 1976 | 818439 |
| animal models of arthritis. | the criteria for selecting and establishing a animal model for arthritis were described. rats are the most frequently used animals. adjuvant and myocobacterium induced arthritis provide a model of chronic joint inflammation, although significant differences exist when compared with human disease. a better model of arthritis in rats and mice can be induced by the injection of one strain of mycoplasma arthritidis. an even better model is presented by rabbits first immunized against a protein such ... | 1976 | 818450 |
| [letter: atypical tuberculosis bacteria]. | | 1975 | 818493 |
| proliferation of synovial tissue cells in rats with adjuvant disease. | proliferation of synovial lining cells and fibroblasts in adjuvant arthritis of rats was investigated by autradiographic methods. as manifestation of the generalized experimental disease increased labelling rates of both cell types were found in all joints. while in the knee joint this cellular proliferation was of a short duration, it progressed in the ankle joint until the joints were destroyed. it is concluded that increased cellular proliferation is an important mechanism leading to joint de ... | 1975 | 818601 |
| [detection of niacin with the paper strip test (author's transl)]. | preparation and application of reagent impregnated paper strips for the detection of niacin are described. 170 cultures of mycobacteria were tested with the paper strips and by the conventional aniline-cyanogen bromide method. the results obtained demonstrate a high degree of correlation. because of its advantages in comparison to the aniline-cyanogen bromide method-the toxic cyanogen bromide is omitted; malachite green does not disturb the reaction-the paper strip test can be recommended withou ... | 1975 | 818830 |
| [homogenization of the specimens for culturing mycobacteria by means of the detergents präwozell n-bx and ditalan e (author's transl)]. | in cooperation of four laboratories the efficiency of the two detergents präwozell n-bx (nekal bx) and ditalan e used for homogenization of diagnostic specimens for cultural investigations on tuberculosis was compared. the pretreatment of sputum specimens was done according to the directions given in "dab 7 (d.l.) - ddr" [german pharmacopocia 7(diagnostic laboratory methods) gdr]. percentage of positive cultures, time of growth and rate of contamination were evaluated. comparative investigations ... | 1975 | 818831 |
| [the value of guinea pig inoculation for the detection of tubercle bacilli in the patients specimens (author's transl)]. | 5912 specimens were examined by culture and animal experiment and the presence of tubercle bacilli was established with one or the other with both methods. an analysis of the results showed, that guinea pig tests in 29.1% of the cases were more accurate than were cultural methods. experimental inoculation is, therefore, still an essential part of the laboratory diagnosis of tuberculosis. materials which are either difficult to obtain, or are suspected to contain few mycobacteria only should be t ... | 1975 | 818832 |
| [a comment on paucibacillary findings in pulmonary tb from the clinical point of view (author's transl)]. | | 1976 | 819138 |