| comparative in vitro activity of the new oral cephalosporin bay v 3522 against aerobic and anaerobic bacteria. | the in vitro activity of the new oral cephalosporin bay v 3522 against 229 aerobic and 330 anaerobic clinical isolates was determined using the agar dilution technique. for comparison, amoxicillin, amoxicillin/clavulanate, cefaclor, cefadroxil, cefuroxime, cephalexin, ciprofloxacin, clindamycin, co-trimoxazole, doxycycline, erythromycin and metronidazole (only anaerobic bacteria) were tested. bay v 3522 was found to have high activity against staphylococcus aureus, staphylococcus epidermidis, en ... | 1990 | 2261923 |
| synthesis and antibacterial activity of the metabolites of 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1h,5h- benzo[i,j]quinolizine-2-carboxylic acid (opc-7251). | the metabolites of 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1h,5h- benzo[i,j]quinolizine-2-carboxylic acid (opc-7251) (1), which has a potent antibacterial activity against gram-positive bacteria, characteristically propionibacterium acnes, were synthesized to confirm their structures and to examine their antibacterial activity. the structures of three major metabolites (2, 3a and 4) were identified by means of comparison with the synthetic compounds. the antibacterial activ ... | 1990 | 2268907 |
| bacteremia due to anaerobic bacteria in newborns. | awareness of the role of anaerobic bacteria in neonatal bacteremia has increased in recent years. the incidence of recovery of anaerobes in neonatal bacteremia varies, according to different studies, between 1.8% and 12.5%. of the 178 cases reported in the literature, 73 were due to bacteroides species (69 were the bacteroides fragilis group), 57 clostridium species (mostly clostridium perfringens), 35 peptostreptococci, 5 propionibacterium acnes, 3 veillonella species, 3 fusobacterium species, ... | 1990 | 2277280 |
| isolation and characterization of a polysaccharide antigen from propionibacterium acnes released by a glycine-specific chemical protein degradation procedure. | an acid-labile antigenic polysaccharide has been isolated from both cell walls and culture media of propionibacterium acnes using a new chemical degradation procedure which liberates protein-bound or associated carbohydrate. lyophilized cells and culture media were treated with a suspension of mercuric oxide in a solution of alkaline mercuric cyanide for several hours at room temperature liberating water-soluble polysaccharide material. the antigenic polysaccharide was freed of reaction products ... | 1990 | 2282114 |
| tnf and inhibition of growth of plasmodium falciparum. | the mechanism of intra-erythrocyte death of plasmodium chabaudi in vivo has not yet been elucidated. here we summarise recent experiments in which serum from mice undergoing a successful immune response to this parasite did not inhibit plasmodium falciparum in vivo unless the p. chabaudi infection and tnf levels were high enough to cause illness in the host. this was true for the 556ka and ds strains of p. chabaudi in intact mice, but not for 556ka in nude mice, which did not generate inhibitory ... | 1990 | 2283147 |
| the influence of various factors on the human resident skin flora. | various factors, e.g. prolonged occlusion, skin disinfectants, systemic antimicrobials, can have an impact on the ecosystem of the normal human skin flora for a short time. these impacts are of clinical importance in the treatment of some skin diseases, where members of the normal human skin flora are involved in the pathogenesis of the disease, e.g. propionibacterium acnes in acne vulgaris, corynebacterium species in erythrasma, trichomycosis palmellina and pitted keratolysis, pityrosporum orbi ... | 1990 | 2285575 |
| [torpid endophthalmitis in pseudophakia: diagnostic and therapeutic difficulties. apropos of 4 cases]. | the authors report four cases of chronic endophthalmitis following extracapsular cataract extraction with intraocular lens implantation in the posterior chamber. the first attack of intraocular inflammation occurred in the form of recurrent iridocyclitis two to six months after surgery. the first attack usually responded well to local corticosteroids. after many relapses of inflammation, increasingly resistant to medical treatment, a severe attack occurred leading to the decision to treat such e ... | 1990 | 2290004 |
| malignant pleural effusions: meaning of pleural-fluid ph determination. | in 36 patients with malignant pleural effusions, we determined the ph and the glucose concentration of the pleural fluid. twenty-one of 36 patients (58.3%) had a low ph (less than 7.30) and 15 had a normal ph (greater than or equal to 7.30; 7.13 +/- 0.12 vs. 7.37 +/- 0.05; p less than 0.0005). the patients with low ph had significantly lower glucose concentrations than those with normal ph (2.7 +/- 1.4 vs. 6.3 +/- 2.9 mmol/l; p less than 0.0005). twenty-one of 34 patients (61.7%) had a glucose c ... | 1990 | 2300387 |
| lethality of morphine in mice infected with toxoplasma gondii. | opiates modulate a variety of immune responses. we investigated the effect of morphine on the pathogenesis of an acute toxoplasma gondii infection. repeated s.c. injections with morphine sulfate (300 mg/kg) every 36 hr addicted mice and increased markedly the mortality of mice infected with an avirulent strain of t. gondii (86%) vs. 0% mortality in addicted and control mice, respectively, p less than .001). however, a single challenge with morphine (300 mg/kg) also markedly (p less than .001) in ... | 1990 | 2313590 |
| diagnosis and treatment of chronic postoperative bacterial endophthalmitis. | bacterial endophthalmitis has been recognized as a significant cause of chronic, delayed-onset inflammation following extracapsular cataract extraction (ecce) with posterior chamber intraocular lens implantation. the diagnosis of chronic postoperative bacterial endophthalmitis should be suspected in any case of chronic, refractory inflammation following ecce. although successful treatment may require surgical intervention in some cases, others may respond to antibiotic therapy alone. | 1990 | 2313707 |
| dorsal midbrain encephalitis caused by propionibacterium acnes. report of two cases. | a syndrome of dorsal midbrain dysfunction in association with a central nervous system anaerobic diphtheroid infection is described. two cases of infection with propionibacterium acnes manifested as shunt malfunctions with a clinical dorsal midbrain syndrome. magnetic resonance images showed increased signal in the midbrain tectum which has decreased slowly over time. the evidence suggesting that this syndrome represents bacterial midbrain encephalitis is discussed. | 1990 | 2319325 |
| propionibacterium acnes orbital abscess. | | 1990 | 2322146 |
| peripheral teflon catheters. potential source for bacterial contamination of orthopedic implants? | to detect low numbers of bacterial cells on teflon catheters removed from peripheral veins, 74 catheter tips were incubated in thioglycollate media for up to ten days. fifteen (20.3%) of the catheters were found to be culture-positive. propionibacterium acnes was isolated from seven, staphylococcus epidermidis from six, and staphylococcus haemolyticus and staphylococcus hominis from one each, all common skin organisms associated with infection of implants. an increase in documentation of bacteri ... | 1990 | 2323139 |
| propionibacterium acnes endophthalmitis two years after extracapsular cataract extraction. | | 1990 | 2333931 |
| [monitoring natural killer cell activity in the blood of patients with malignant pleural effusion after intrapleural administration of corynebacterium parvum]. | in a group of 14 patients with a malignant pleural effusion treated by intrapleural administration of corynebacterium parvum, in addition to other treatment of the generalized malignant process the activity of nk cells was investigated before administration, on the 7th and 21st day after instillation of the vaccine. the mean rise of this activity was significant at the 5% level of significance. the activity of nk cells was equally significantly influenced by age. the survival of patients, althou ... | 1990 | 2340567 |
| propionibacterium acnes in a spondylitis with palmoplantar pustulosis. | | 1990 | 2344218 |
| enhanced tumor necrosis factor and interleukin-1 in an experimental model of massive liver cell necrosis/fatal hepatitis in mice. | studies were conducted to investigate possible roles of tumor necrosis factor (tnf) and interleukin-1 (il-1) in liver cell necrosis/fatal hepatitis in mice which were injected with propionibacterium acnes (p.acnes) and subsequently 7 days later with a small dose of lipopolysaccharide-endotoxin (lps). higher serum levels of tnf were observed in the model, and enhanced production of both tnf and il-1 was also found in hepatic as well as splenic adherent cells that were isolated from mice pretreate ... | 1990 | 2358165 |
| the interaction of naegleria fowleri amoebae with murine macrophage cell lines. | the present study was undertaken to determine whether murine macrophage cell lines exhibited in vitro amoebicidal activity comparable to that elicited by activated murine peritoneal macrophages. peritoneal macrophages activated in vivo by bacillus calmette-guérin or propionibacterium acnes demonstrated significant cytolysis of naegleria fowleri amoebae. the macrophage cell line raw264.7 also effected cytolysis of amoebae, but to a lesser extent than that elicited by activated peritoneal macropha ... | 1990 | 2359044 |
| [comparative study of the bacterial flora in both uterocervical and uterine regions]. | the relationship between indigenous bacterial floras in the lower genitals and the uterocervical region is of importance due to a barrier-like role against ascending infections through the mechanism of the localized protection at a boundary of the uterocervical region. therefore, bacterial flora in the uterocervical and uterine regions was studied in cases for which gynecological operations were performed (n = 77). 1. ratios of incidences of the detection of bacteria on the uterocervical and in ... | 1990 | 2362354 |
| effector phenotype and immunologic specificity of t-cell-mediated adoptive therapy for a murine tumor that lacks intrinsic immunogenicity. | the mca 102 sarcoma has been defined by a variety of immunologic studies as a tumor lacking intrinsic immunogenicity. nevertheless, we have recently demonstrated the feasibility of generating therapeutically effective lymphocytes for adoptive immunotherapy of this tumor. procedures to achieve this required in vivo priming of syngeneic mice to elicit preeffector cells followed by in vitro sensitization (ivs) with tumor cells in the presence of il-2. by selective depletion of t cell subsets in viv ... | 1990 | 2364440 |
| vaccination of humans against cutaneous leishmaniasis: cellular and humoral immune responses. | brazilian army conscripts were vaccinated against american cutaneous leishmaniasis by using nonliving polyvalent promastigote leish vaccine 5 or leish vaccine 6 (vaccines with five or six leishmania stocks) with or without corynebacterium parvum. no statistically significant differences in lymphocyte stimulation indices were found between vaccinated groups with or without c. parvum, but lymphocyte stimulation indices of all vaccinees were significantly higher (p less than 0.001) than those of th ... | 1990 | 2365458 |
| bacteria from solid tumours. | bacteria were grown from 63 (69%) of 91 specimens from necrotic tumours in 63 patients. of the tumours, 14 were abdominal, 5 pelvic, 23 of the head and neck, 4 of the lungs, 4 mediastinal, 2 lymphatic, 3 of the breast, and 8 were miscellaneous. aerobic or facultatively anaerobic bacteria only were present in 12 (19%) specimens, anaerobes only in 10 (16%), and mixed aerobic and anaerobic bacteria in 41 (65%). a total of 83 anaerobic and 47 aerobic and facultatively anaerobic bacteria were isolate ... | 1990 | 2374159 |
| [histochemical study of proliferating cells in the spleen in mice with acute hepatic injury]. | when heat-killed propionibacterium acnes (p. acnes) and lipopolysaccharide (lps) were injected into mice, liver cell necrosis with infiltrating neutrophils and macrophages were induced. proliferating cells in the spleen were histochemically investigated. p. acnes injection rapidly produced hyperplasia of neutrophils and macrophages in the red pulp of the spleen. the proportion of bromodeoxyuridine positive cells reached a peak at 5 days after injection of p. acnes. these results indicate that pr ... | 1990 | 2376907 |
| involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice. | the possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. balb/c mice were primed with propionibacterium acnes to induce the infiltration of mononuclear cells into the liver. immunohistochemical study showed that most of the accumulated mononuclear cells at 7 days were mac-2 positive, suggesting that they were activated macrophages. an injection of lipopolysaccharide resulted in massive hepatic necrosis and high mortality ... | 1990 | 2379780 |
| infectious arthritis caused by propionibacterium acnes: a new case. | | 1990 | 2396878 |
| contact neodynium-yttrium-aluminum garnet laser acts as a sterilizing scalpel. | as a cold knife cuts through contaminated or infected wounds, bacteria are dragged along with the blade of the knife through the entire wound. herein, the effect of incisions made with a cold knife is compared with that of incisions made by a contact neodynium-yttrium-aluminum garnet (nd:yag) laser. agar plates were inoculated with multiple strains of exogenous, endogenous, hospital-acquired and multiple antibiotic resistant strains of bacteria. while the cold knife dragged bacteria to sterile a ... | 1990 | 2403698 |
| complications associated with ommaya reservoirs in patients with cancer. the princess margaret hospital experience and a review of the literature. | the complications associated with the use of ommaya reservoirs in 106 patients with meningeal involvement due to malignant disease are reviewed. twenty-seven patients had acute lymphoblastic leukemia, 12 acute myelogenous leukemia, 3 chronic lymphocytic leukemia, 34 lymphoma, 29 carcinoma, and 1 chronic myelocytic leukemia. there were 11 technical complications, including 1 death due to misplacement of the catheter, 2 mild intraventricular hemorrhages, and 5 malfunctioning reservoirs; 3 required ... | 1990 | 2404479 |
| attempts to correlate interferon induction and activation of natural killer cells by corynebacterium parvum. | intraperitoneal (i.p.) injection of poly i:poly c resulted in high interferon titers in the peritoneal wash fluid and in the serum of mice, which was maximal at 4 to 6 h after injection. in contrast, no interferon could be measured in the peritoneal fluid at various times after injection of c. parvum. also, all attempts to induce serum interferon by c. parvum were unsuccessful. however, both poly i:poly c and c. parvum were causing the activation of natural killer (nk) cells in the cell populati ... | 1985 | 2408996 |
| comparison of the neovascular effects of stimulated macrophages and neutrophils in autologous rabbit corneas. | the ability of peritoneal exudate macrophages and neutrophils to induce neovascularization was tested in autologous rabbit corneas. macrophages and neutrophils elicited by proteose peptone or glycogen and macrophages activated by c parvum were purified, pelleted, and implanted 1-2 mm from the corneal limbus. neovascular responses were evaluated by daily slit-lamp observations and terminal whole-mount and histologic examinations of colloidal carbon-perfused vessels. pellets of elicited macrophage ... | 1985 | 2409810 |
| interferon inducibility in mice treated with corynebacterium parvum. | mice were given single intraperitoneal (i.p.) injections of corynebacterium parvum, followed, after different time intervals, by i.p. injections of the interferon inducers polyinosinic-polycytidylic acid (poly-i:poly-c), 10-carboxymethyl-9-acridanone (cma) or herpes simplex virus. with all three inducers production of interferon in the peritoneal cavity was enhanced in c. parvum-pretreated mice. production of circulating interferon in c. parvum-pretreated mice was enhanced with cma and depressed ... | 1985 | 2409917 |
| hyporesponsiveness to augmentation of murine natural killer cell activity in different anatomical compartments by multiple injections of various immunomodulators including recombinant interferons and interleukin 2. | augmentation of natural killer (nk) cell activity has been observed after the single administration of a wide variety of biological response modifiers (brm); however, multiple injections of brm have resulted in hyporesponsiveness to nk augmentation in both preclinical and clinical studies. in these studies, hyporesponsiveness to augmentation of nk cell activity occurred after multiple injections of interferon (ifn recombinant human ifn-alpha a/d and recombinant ifn-gamma) and interleukin 2 and w ... | 1985 | 2411797 |
| comparative study of chemotherapy and/or immunotherapy of established experimental brain tumors. | | 1985 | 2415843 |
| enzyme production of propionibacteria from patients with acne vulgaris and healthy persons. | 375 strains of propionibacteria isolated from pustules, comedones, and from normal skin of patients with acne vulgaris and from healthy persons have been examined for their enzymatic activity. in contrast to healthy individuals, protease and caseinase production of strains from acne patients was significantly lower. on the other hand, dna'ase production of strains from acne lesions was increased, and lecithinase could be demonstrated in strains from acne patients only. | 1985 | 2416168 |
| antimicrobial activity of various immunomodulators: independence from normal levels of circulating monocytes and natural killer cells. | the effects of 89sr treatment on the natural host resistance of cd-1 mice and the enhancement of resistance by immunomodulators to infection with listeria monocytogenes or herpes simplex virus type 2 (hsv-2) were determined. in the cd-1 mouse, single-dose treatment with 89sr caused a profound decrease in the number of circulating monocytes (mo), lymphocytes, and polymorphonuclear leukocytes (pmn) within 1 week. there was also marked functional impairment of the mo inflammatory response, as well ... | 1986 | 2416693 |
| on the role of endogenous interferon in natural and induced antiviral resistance. | | 1985 | 2417549 |
| immunological adjuvants of natural origin and their adverse effects. | | 1986 | 2422897 |
| [microbial pathogenesis of whipple's disease]. | in a case of whipple's disease with electron microscopic demonstration of rod-shaped bacteria we could isolate propionibacterium acnes (former name: corynebacterium anaerobium), actinomyces, and lactobacillus from duodenal biopsies by the aid of modern anaerobic culture technique. simultaneously we found a dysbiosis (increase of anaerobic coca and anaerobes) in du odenal juice. after antibiotic treatment propionibacterium and lactobacillus disappeared and an other type of dysbiosis (appearance o ... | 1986 | 2424711 |
| aspartate-assisted immune stimulation: its importance in antitumor and antiviral protection. | immune stimulators such as corynebacterium parvum (cp) are useful for antitumoral and antiviral therapy. however, the immune trigger cannot be reactivated without adversely affecting the disease. we have tried to amplify the results yielded by a single injection of cp by using either interleukin-2 (il2) or aspartate salts (asp). in the present report, we show that il2 has no detectable clinical effect. in contrast, the addition of an asp salt increases the antiviral and antitumoral protection af ... | 1986 | 2426209 |
| immune modulating therapy in gastrointestinal cancer. | | 1986 | 2426941 |
| interferon-mediated protection of b16 melanoma cells from cytotoxicity by activated macrophages. | corynebacterium parvum-activated macrophages (m phi), purified by adherence, were cytotoxic for b16 melanoma cells maintained in vitro. pretreatment of the melanoma cells for 18 hr with interferon-alpha/beta or -gamma (ifn-alpha/beta or -gamma) caused a reduced susceptibility of the b16 cells to m phi-mediated cytotoxicity. the ifn-induced protective effect of b16 cells from cytotoxic m phi was found to be dose dependent. in addition, ifn-gamma was more protective than ifn-alpha/beta. the protec ... | 1986 | 2427205 |
| effects of diethylstilbestrol on propionibacterium acnes immunomodulation: inhibition of macrophage activation and antitumor activity. | exposure of mice to diethylstilbestrol (des) inhibited propionibacterium acnes-induced antitumor activity in vivo against the b16f10 subcutaneous tumor. the inhibitory effect was associated with inhibition by des of the characteristic p. acnes induced splenomegaly and changes in splenic and peritoneal macrophages (m phi) cell populations. the characteristic p. acnes induced reductions in m phi alkaline phosphodiesterase i (apd) ectoenzyme activity and in total rna synthesis, proposed biochemical ... | 1986 | 2430037 |
| natural immunity to grafts of fld-3 erythroleukemia cells by irradiated mice. | mice were irradiated and infused with balb/c friend virus-induced fld-3 erythroleukemia cells. growth of the cells was estimated by measuring splenic incorporation of 5-iodo-2'-deoxyuridine-125i 5 days after cell transfer. balb/cj and c3h mice were 'poor responders' in that fld-3 cells grew well in their spleens, while mice of other strains were 'good responders', resisting the growth of fld-3 cells. no h-2 or fv genetic locus was associated with resistance. athymic nude mice and mice depleted o ... | 1986 | 2430178 |
| [comparative studies of the immunostimulating (paramunizing) effectiveness of bcg, levamisole, corynebacterium parvum and preparations of pock viruses in various in vivo and in vitro tests]. | | 1986 | 2430381 |
| the effect of oral zinc administration on sebum free fatty acids in acne vulgaris. | free fatty acids in sebum arise from lipolytic action of bacterial lipases. we have demonstrated an inhibitory effect of zinc on the lipase of the three propionibacterium species found in human pilosebaceous follicles. we were also able to show a small corresponding fall in the free fatty acid content of skin surface lipid in vivo in acne patients treated with zinc, though this failed to reach statistical significance. | 1986 | 2430400 |
| corynebacterium parvum in malignant pleural effusion. a randomized prospective study. | in a randomized trial, pleurodesis was attempted with corynebacterium parvum in one group and bleomycin in another. patients with malignant pleural effusion which required repeated drainage were treated with instillation of one of these agents after complete drainage of the pleural effusion. there were 32 patients who could be evaluated. sixty-five per cent of the patients treated with c. parvum had no recurrence after one treatment and another 29% after two treatments. in the bleomycin group, t ... | 1986 | 2430825 |
| interferon production in propionibacterium acnes treated mice. | interferonogenic properties of propionibacterium acnes (pa) was studied in vivo and in vitro using cba, balb/c and 129aoboy strains of mice. ifn was induced only in cba strain after i.v. pa injection. balb/c and 129aoboy mice did not produce ifn. in the sera of cba mice, obtained after i.p. injection of pa, interferon was not found. however, spleen cells of these mice produced ifn beginning from the 3rd day after injection. this interferon response lasted until the 10th week. furthermore, in viv ... | 1986 | 2431669 |
| prolongation of survival of mice bearing the eb and esb lymphoma by treatment with interferon inducers alone or in combination with corynebacterium parvum. | the objective of this study was to evaluate if pretreatment with corynebacterium parvum (c. parvum) augments the effects of interferon (ifn) inducers on survival of dba/2 mice transplanted with two syngeneic lymphoma variants, the low metastatic eb and the high metastatic esb tumor. the involvement of ifn in the treatment effects was investigated. as inducers of ifn-alpha/beta newcastle disease virus (ndv), polyinosinic-polycytidylic acid (polyi:polyc), and 10-carboxymethyl-9-acridanone (cma) we ... | 1986 | 2431778 |
| tests on protection against viral diseases. | despite many attempts to find reliable in vitro criteria for the efficacy of biological response modifiers--brms (immunomodulators, paramunity inducers) animal challenge models are still the only way to demonstrate the totality of interlocking defense mechanisms. challenge models with mouse pathogenic viruses provide an excellent possibility to study protective effects of brms against acute or chronic forms of viral diseases. for comparative studies two completely different virus challenge model ... | 1986 | 2431829 |
| symptomatic treatment of recurrent malignant pleural effusions with intrapleurally administered corynebacterium parvum. clinical response is not associated with evidence of enhancement of local cellular-mediated immunity. | intrapleural injection of corynebacterium parvum (cbp) has been recently proposed as a useful symptomatic treatment of recurrent malignant effusions. although the result is often a fibrotic thickening of the pleura, cbp is thought to stimulate the effector cells present in the effusion and, possibly, to activate the antitumor cytotoxic activity of the pleural fluid mononuclear cells. to test this hypothesis, we studied 7 patients with recurrent malignant pleural effusions caused by lung cancer a ... | 1987 | 2436513 |
| role of interferon, antibodies and macrophages in the protective effect of corynebacterium parvum on encephalomyocarditis virus-induced disease in mice. | treatment of mice with corynebacterium parvum enhances their resistance to encephalomyocarditis (emc) virus infection. in emc-virus-infected mice, pretreated with c. parvum, neither interferon production nor antibody responses were increased. a decrease of virus recovery was observed in cultures of macrophages taken from the peritoneum of mice early after injection of c. parvum and infected with emc-virus in vitro. the data suggest that c. parvum acts by increasing intrinsic antiviral activity o ... | 1987 | 2440381 |
| [isolation of propionibacterium acnes from a cervical lymph node in whipple's disease]. | | 1987 | 2440756 |
| treatment of mice with indomethacin leads to the appearance of a 125,000 dalton plasma protein with the characteristics of an acute phase reactant. | sds-page analysis of plasma samples from mice injected with high, but nontoxic, concentrations of indomethacin led to the detection of elevated levels of a 125,000 dalton protein. the appearance of this protein was rapid, occurring within 24 hrs after a single injection of the drug. treatment of mice with similar concentrations of sulindac and derivatives, the indomethacin analogs mk-410 and mk-555, or high doses (1 mg/day) of aspirin, did not induce the appearance of this protein. however, the ... | 1987 | 2442392 |
| endogenous production of tumor necrosis factor in normal mice and human cancer patients by interferons and other cytokines combined with biological response modifiers of bacterial origin. | the priming effect of endogenous biological response modifiers (brms), interferons (ifns), and interleukin-2 (il2), and the triggering effect of brms of bacterial origin, ok-432 and corynebacterium parvum, on endogenous production of the tumor necrosis factor (tnf) were investigated in mice. tnf activity in serum was measured by in vitro cytotoxicity assay with l-929 cells as a target. the i.v. injection of ok-432 (3ke per mouse) triggered tnf maximally (mean value: 30 u/ml) after 2 h, with a si ... | 1987 | 2445926 |
| isotretinoin--an explanation for its long-term benefit. | isotretinoin is of undisputed benefit in the treatment of acne. in doses of 1 mg/kg/day for 4 months the drug produces a highly significant reduction in sebum excretion rate (90 +/- 3%) in comedone formation as measured by assessing follicular casts (70 +/- 5%), and in surface propionibacterium acnes. however, the mechanisms of long-term clinical remission are not well understood. there are however, risk factors which predetermine the outcome to treatment with isotretinoin. younger subjects (14- ... | 1987 | 2446935 |
| [immunotherapy of mice bearing myeloma and el4 leukemia]. | | 1987 | 2447213 |
| modulation of major histocompatibility complex (mhc) expression by interferons and microbial agents. independent regulation of mhc class ii expression and induction of tumoricidal activity in bone marrow-derived mononuclear phagocytes. | in a pure population of rat bone marrow-derived mononuclear phagocytes (bmm phi), the expression of major histocompatibility complex (mhc) molecules and ability to manifest tumoricidal activity were simultaneously studied. resting bmm phi, which express low levels of mhc class ii molecules and do not manifest tumoricidal activity, become strongly mhc class ii-positive, and evolve tumoricidal activity within 24 h when incubated with macrophage-activating lymphokines (maf) or gamma interferon (ifn ... | 1988 | 2456605 |
| the use of non-specific immunopotentiators in experimental trypanosoma cruzi infection. | the effects of levamisole, isoprinosine and corynebacterium parvum on trypanosoma cruzi (y strain) experimental infection of mice were studied. in prophylactic treatment these drugs reduced the peak of parasitaemia, and had no apparent effect on mortality rate or on histopathological and electrocardiographic findings. levamisole and isoprinosine had no effect when used after infection. electrocardiograms were obtained from all chronic chagasic mice. the most frequent changes were left atrial ove ... | 1988 | 2459820 |
| [pleurodesis as a palliative method in the treatment of pleural effusions of malignant etiology]. | | 1988 | 2460882 |
| [interferon production and natural killer activity of peripheral blood lymphocytes obtained from patients with multiple sclerosis]. | interferon (ifn) -system of patients with multiple sclerosis (ms) during the stable stage of the disease activity was investigated. thirty six patients were divided into 3 groups of mild, moderate and severe patients according to the scores of disability status scale (dss). ifn-alpha producibility and natural killer (nk) activity of peripheral blood lymphocytes (pbl) or large granular lymphocytes (lgl) fractionated from pbl were determined by culturing with hela cells persistently infected with ... | 1988 | 2464533 |
| enhancement of nonspecific resistance to viral infection by chemically synthesized lipid a-subunit analogs with different backbone structures and acyl groups. | protection against vaccinia virus infection and induction of interferon (ifn) were investigated in propionibacterium acnes-primed mice following treatment with chemically synthesized lipid a-subunit derivatives. the antiviral activity was based on the reduction of numbers of tail lesions in mice injected intravenously with the test compounds 1 day before virus infection. gla-27, a 4-o-phosphono-d-glucosamine carrying 3-o-tetradecanoyl (c14) and n-3-tetradecanoyloxytetradecanoyl [c14-o-(c14)] gro ... | 1988 | 2465734 |
| a randomized trial of intracavitary bleomycin and corynebacterium parvum in the control of malignant pleural effusions. | fifty-eight patients with malignant pleural effusions were entered into a prospectively randomized clinical trial comparing the efficacy of a local instillation of bleomycin or corynebacterium parvum (c. parvum) in controlling fluid reaccumulation after simple needle aspiration (thoracentesis). the response was assessed at 30 days by chest x-ray and clinical examination. there were 44 evaluable patients; 18 of 25 (72%) of those receiving bleomycin and 9/19 (47%) of those who had c. parvum gained ... | 1989 | 2467327 |
| the microbial content and complement c3 cleaving capacity of comedones in acne vulgaris. | complement c3 deposition around lesions is an early event in the inflammation of acne vulgaris. the aims of this study were to determine the relationship between the capacity of individual comedones to cleave complement c3 and their microbial flora. the contents of 48 open comedones were expressed from the upper back of acne vulgaris patients and each comedo was homogenized individually and assayed for microbial content and capacity to induce cleavage of complement c3 in an in vitro assay system ... | 1988 | 2467483 |
| intracavitary therapy with bleomycin for the treatment of malignant pleural effusions. | this paper briefly reviews the incidence of malignant pleural effusions (mpe) and the measures that have been used to treat this condition. the role of intracavitary bleomycin in controlling mpe, the doses used, and morbidity associated with its use are reviewed in depth with reference to multicenter studies that the author has coordinated as well as the published literature. the short- and long-term results reported when bleomycin was used alone or as compared with other agents are discussed. t ... | 1989 | 2475118 |
| comparison of corynebacterium parvum and bordetella pertussis with freund's complete adjuvant as immunopotentiators for beta-human chorionic gonadotropin linked to an atoxic fragment of tetanus toxin. | corynebacterium parvum and bordetella pertussis were compared with freund's complete adjuvant (fca) for their abilities to potentiate the immune response to haptenic beta-human chorionic gonadotropin covalently coupled to an atoxic 54,000-molecular-weight fragment of tetanus toxin (beta-hcg-ttii). the ability of each adjuvant to enhance production of antibodies to hcg in rabbits was measured by 125i-hcg radioimmunoassay. at sera dilutions of 1:10,000, analysis of variance for the 8-week postimmu ... | 1989 | 2475138 |
| analysis of propionibacterium acnes-induced non-specific immunity to trypanosoma brucei in mice. | mice treated with dead propionibacterium acnes (previously called corynebacterium parvum), up to 30 days before infection with any of three strains of trypanosoma brucei, were more able to limit the level of first-wave parasitaemia than untreated controls. reduced parasitaemia was not due to enhanced phagocytosis of input parasites and was associated with a dramatic reduction in the proportion of multiplying t. brucei in the blood of treated as compared to control mice. for 4 days after p. acnes ... | 1989 | 2476711 |
| characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to corynebacterium parvum or poly i: poly c. | the biological significance of acid labile interferon alpha is presently unknown. we examined the putative production of acid labile interferon in vitro from human peripheral blood mononuclear cells induced with corynebacterium parvum or poly i: poly c. both agents induced up to 1200 iu/ml interferon, and the interferon was 80 to 90% acid labile. the interferons were typed by antibody neutralization of their antiviral activity. contrary to previous reports, c. parvum induced predominantly interf ... | 1989 | 2483976 |
| modulation of macrophage functions by corynebacterium parvum preparations. | corynebacterium parvum has been used as an anti-tumor agent in both animal experiments and clinical trials; nevertheless it is not well established the mechanism of action, since both t-dependent and t-independent ways of action have been proposed. on the other hand, mononuclear phagocytic system activation cannot be ruled out in the immunomodulation carried out by c. parvum. in the attempt to better understand the effects of c. parvum on macrophage functions, experiments were carried out on tum ... | 1989 | 2491287 |
| protective effect of sk&f 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action. | the effect of a new, structurally novel, dual inhibitor of arachidonic acid (aa) metabolism, sk&f 86002, was studied in two murine models of endotoxin shock. the first model was the injection of c57bl/6 mice with lipopolysaccharide (lps) in combination with d-galactosamine (d-gal), which resulted in death within 6-48 hr. treatment of these mice with sk&f 86002 (100 mg/kg, p.o.) 30 min to 2 hr prior to the administration of d-gal and lps protected the animals from mortality. protection was also p ... | 1989 | 2492908 |
| epithelial dendritic cells and connective tissue macrophages in oral carcinogenesis and the effects of systemic corynebacterium parvum. | epithelial dendritic cells (edc) and connective tissue macrophages were examined during the induction and growth of oral squamous cell carcinomas in sprague-dawley rats treated with the carcinogen 4-nitroquinoline n-oxide (4nqo) and the immune potentiator corynebacterium parvum. splenomegaly was induced in all animals receiving c. parvum. acetone-fixed frozen sections of the palate and tongue were stained using an indirect immunoperoxidase technique and monoclonal antibodies to rat ia (mrc ox-6) ... | 1989 | 2493998 |
| contamination of k-sol corneal storage medium with propionibacterium acnes. | k-sol is a widely used corneal preservation medium. it has an excellent record for corneal storage and no previous report of contamination. during september 1988, on five of our k-sol-stored donor rims propionibacterium acnes grew. cultures of unopened k-sol also yielded p acnes. this report reviews previous contaminations of corneal storage media and the special characteristics of p acnes that enabled it to survive precautions taken against infection. the detection of p acnes was not obvious, a ... | 1989 | 2502104 |
| corneal ulcers associated with disposable hydrogel contact lenses. | four patients developed corneal ulcers associated with the use of disposable extended-wear hydrogel contact lenses. bacteria were recovered from corneal ulcers in three of the patients. three patients discarded their contact lenses after ten or more days of extended wear; the corneal ulcers in these patients developed toward the end of the wearing cycle. the fourth patient removed her contact lenses every two days for cleaning and disinfection and discarded them for a new pair on a weekly basis. ... | 1989 | 2502923 |
| lipoarabinomannan from mycobacterium tuberculosis induces the production of tumour necrosis factor from human and murine macrophages. | we show here that purified lipoarabinomannan (lam) from mycobacterium tuberculosis can cause the release of tumour necrosis factor (tnf) in vitro from human blood monocytes and activated mouse peritoneal macrophages, and the production of tnf in vivo in mice pretreated with propionibacterium acnes, with a potency comparable to that of lipopolysaccharide (lps) from gram negative bacteria. like lps, lam binds to polymyxin b. we confirmed that its activity was distinct from any contaminating lps an ... | 1989 | 2503277 |
| discrepancy in the abilities of lymphokines and bacteria to mediate tumor protection in vivo and/or tumoricidal activity by macrophages in vitro. | in the present study, the ability of lymphokines (maf and ifn gamma) and microbial agents (cp and lm) to induce and maintain tumoricidal activity in bmmp in vitro and to enhance local resistance to the da rat d-12 ascites tumor in vivo was assessed comparatively. under standard conditions in vitro, i.e., when present during the 24-hr induction and the 36-hr effector phase, both lymphokines and microbes were similarly potent for eliciting tumoricidal activity in bmmp. when the activating agents w ... | 1989 | 2506137 |
| lung-phase immunity to schistosoma mansoni. flow cytometric analysis of macrophage activation states in vaccinated mice. | a delayed-type hypersensitivity response has been postulated as the effector mechanism of lung-phase immunity to schistosoma mansoni. we have sought evidence for this response by examining the state of alveolar macrophage activation in c57bl/6 mice vaccinated with radiation-attenuated cercariae, and challenged with normal parasites. as an index of activation, the capacity of macrophages to produce an oxidative burst upon stimulation with pma, was measured at the single cell level by a flow cytom ... | 1989 | 2506284 |
| abilities of activated macrophages to manifest tumoricidal activity and to generate reactive nitrogen intermediates: a comparative study in vitro and ex vivo. | the abilities of lymphokines and heat-killed bacteria to induce and to maintain tumoricidal activity and/or the secretion of reactive nitrogen intermediates (rni) were comparatively assessed in bone marrow-derived mononuclear phagocytes (bmm phi) in vitro and in adherent peritoneal cells (apc) ex vivo. in showing that the kinetics of tumoricidal activity and of secretion of rni induced by macrophage-activating agents in bmm phi and/or in peritoneal cells do largely parallel each other, the prese ... | 1989 | 2511844 |
| erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure. | erythromycin resistant (emr) propionibacteria were isolated from the skin surface of 51% of patients treated with oral erythromycin and 42% of patients treated with topical clindamycin compared with 3% of untreated control subjects (p less than 0.001). amongst the topical clindamycin-treated patients, there was a higher incidence of emr propionibacterial carriage in those patients who had previously been treated with oral erythromycin (64%) than in patients with no known previous exposure to ery ... | 1989 | 2527056 |
| acne necroticans (varioliformis) versus propionibacterium acnes folliculitis. | | 1989 | 2527876 |
| role of propionibacterium acnes in cancer risk. | | 1989 | 2528369 |
| [azelaic acid in the treatment of acne]. | this review is an update of the literature accumulated over the past 6 years following the original observation that topically applied azelaic acid, a non-toxic c9 dicarboxylic acid, has a beneficial therapeutic effect on acne vulgaris. these studies have shown that azelaic acid has a modulating influence on the process of keratinization, and that it acts as a keratolytic and anti-comedogenic agent. there is evidence that it inhibits mitochondrial and microsomal oxido-reductases, including 5-alp ... | 1989 | 2530163 |
| microscopic changes of the urinary bladder in patients with primary tumors locally treated with corynebacterium parvum. | the study covered 34 patients with tumors of the urinary bladder treated surgically by transurethral resection and, as an adjuvant therapy, with corynebacterium parvum intravesically administered. microscopic observations were performed on smears stained with blue polychrome-tannin and the histologic study used preparata stained with hematoxylin-eosin and van gieson. after the second series of instillations, many biopsies from the same patient were taken. the investigation revealed the negativit ... | 1989 | 2533966 |
| [mechanism of azelaic acid action in acne]. | the physiopathologic mechanism of acne seems to be dependent on four main factors: a) sebum production and excretion; b) type of keratinization of the follicular channel; c) microbial colonization of the pilosebaceous unit and d) inflammatory reaction of the perifollicular area. azelaic acid is effective in the treatment of acne because it possesses an activity against all of these factors. azelaic acid is a competitive inhibitor of mitochondrial oxidoreductases and of 5 alpha-reductase, inhibit ... | 1989 | 2534550 |
| effect of sodium diethyldithiocarbamate, corynebacterium parvum and mycobacterium cell wall extract on in vitro blastogenic responses of bovine blood lymphocytes. | in vivo inoculation of three-month-old calves with sodium diethyldithiocarbamate (dtc), killed corynebacterium parvum or mycobacterium cell wall extract (mcwe) resulted in an enhancement of in vitro peripheral blood lymphocyte blastogenic responses to mitogens phytohemagglutinin (pha) and concanavalin a (con a) in the first three days after treatment. in a separate experiment, blood lymphocytes isolated from a healthy nontreated calf were incubated in vitro in presence of each of the same immuno ... | 1989 | 2536308 |
| delta-9-tetrahydrocannabinol inhibits macrophage protein expression in response to bacterial immunomodulators. | the objective of this study was to determine the effect of delta-9-tetrahydrocannabinol (delta-9-thc), the major psychoactive component of marihuana, on macrophage protein expression in response to bacterial immunomodulators. peritoneal macrophages of (b6c3)f1 mice receiving propionibacterium acnes exhibited a novel protein profile when compared to resident or vehicle-treated macrophages. in contrast, macrophages from mice treated with p. acnes in concert with delta-9-thc exhibited profiles for ... | 1989 | 2537903 |
| regulation of macrophage functions by l-arginine. | sites of inflammation with prominent macrophage infiltration, such as wounds and certain tumors, are uniquely deficient in free arginine. the effects of arginine availability on macrophage physiology were investigated. when cultured in media containing less than 0.1 mm l-arginine, rat resident peritoneal macrophages exhibited enhanced spreading, tumor cytotoxicity, superoxide production, phagocytosis, and protein synthesis. thus, arginine concentrations similar to those found in sites of inflamm ... | 1989 | 2538541 |
| aetiology of kawasaki disease. | thirteen serum samples from nine children with kawasaki disease and 23 control samples gave negative results on screening for antibodies to hog cholera virus, border disease of sheep, bovine diarrhoea virus, and equine arteritis virus. the sera from two children with kawasaki disease were cytotoxic; a possible link with cytotoxin from propionibacterium acnes is considered. | 1989 | 2539788 |
| bronchoalveolar leukocyte response in experimental silicosis: modulation by a soluble aluminum compound. | the biological properties of quartz have been related to its surface reactivity. we have addressed the role of particle surface reactivity in mediating the biological activity of quartz in mixed dusts, by treating the quartz with aluminum lactate. intratracheal instillation of untreated quartz in rats caused a rapid, sustained alveolitis and bronchoalveolar leukocytes obtained from these animals had enhanced activity in degrading fibronectin, but reduced ability to mount a respiratory burst. qua ... | 1989 | 2552617 |
| susceptibility of anaerobic bacteria to meropenem. | the activity of meropenem was determined against 350 strains of anaerobic bacteria by an agar dilution method. it was compared with those of piperacillin, cefoxitin, imipenem, clindamycin, metronidazole and chloramphenicol. meropenem and imipenem were the most active agents tested. on the basis of these results, meropenem appears to be a promising antimicrobial agent for anaerobic infections and warrants further clinical investigation. | 1989 | 2553656 |
| changes in number and density of large granular lymphocytes upon in vivo augmentation of mouse natural killer activity. | nk activity of mice as well as humans and rats has been clearly associated with large granular lymphocytes (lgl). to better understand the effects of interferon (ifn) and ifn inducers on natural killer (nk) cells, we have compared the lgl in the spleens of normal and boosted mice. cells were fractionated by centrifugation on discontinuous percoll density gradients, and each fraction was tested for nk activity against yac-1 targets and for the presence of lgl. in vivo treatment with c. parvum (0. ... | 1985 | 2579157 |
| immunologic aspects of gynecologic cancer. | | 1985 | 2579358 |
| recent developments in immunomodulatory therapy. | | 1985 | 2579994 |
| anaerobic bacterial bacteremia: 12-year experience in two military hospitals. | clinical and microbiologic data of 296 patients with anaerobic bacteremia were reviewed. anaerobes were isolated with aerobic or facultative bacteremia in 23 instances. the bacteroides fragilis group accounted for 148 (70%) of 212 isolates of bacteroides species. b. fragilis accounted for 78% and b. thetaiotaomicron for 14%. among other species, there were 20 (6%) fusobacterium organisms, 63 (18%) clostridium isolates, and 53 (15%) anaerobic cocci. seventy-five patients died: 40 had b. fragilis ... | 1989 | 2584754 |
| [studies of the effects of bcg and corynebacterium parvum vaccines in experimental infection of mice with influenza virus. foot pad test, splenic indicator and histologic changes in the thymus gland, spleen and lymph nodes]. | evaluation of the influence of bcg and coparvax on reticulo-endothelial system in mouse was performed. mice were stimulated i.p. with bcg vaccine and coparvax vaccine. spleen index and histological changes in thymus, spleen and lymph nodes were evaluated after 14 days in mice vaccinated with bcg and after 7 days in mice vaccinated with coparvax. foot pad test was also performed by giving vaccine into three feet. tuberculin was injected into mouse foot pad on the day 7th and 14th and a lysate of ... | 1989 | 2586194 |
| effect of intracerebrally injected corynebacterium parvum on the development and growth of metastatic brain tumor in mice. | using kht tumor in a mouse metastatic tumor model, we examined the effect of intracerebral and/or intraperitoneal injections of corynebacterium parvum on the growth of metastatic brain tumor and the development of an inflammatory response in the central nervous system (cns). c. parvum given intraperitoneally had no effect on the development and growth of cns tumor, but did prolong the survival of mice by inhibiting the growth of systemic metastatic tumor, which was the cause of death in our tumo ... | 1989 | 2586725 |
| comparison of the nasal bacterial floras in two groups of healthy subjects and in patients with acute maxillary sinusitis. | the nasal bacterial flora was studied in 183 healthy men entering military service (entry group), 103 healthy recruits in service (service group), and 185 recruits with acute maxillary sinusitis. the 267 nasal and ipsilateral sinus aspirate findings in the same patients with acute maxillary sinusitis were compared pairwise. in the entry group presumed sinus pathogens were only rarely isolated from the nasal cavities: haemophilus influenzae in 4%, streptococcus pneumoniae in 1%, branhamella catar ... | 1989 | 2592539 |
| studies on antibacterial agents. i. synthesis of substituted 6,7-dihydro-1-oxo-1h,5h-benzo[i,j]quinolizine-2-carboxylic acids. | a series of substituted 6,7-dihydro-1-oxo-1h,5h-benzo[i,j]quinolizine-2-carboxylic acids was synthesized and tested for antibacterial activities. among them, 9-fluoro-6,7-dihydro-5-methyl-8-(4-methyl-1-piperazinyl)-1-oxo-1h,5h- benzo[i,j]quinolizine-2-carboxylic acid (opc-7241) exhibited potent antibacterial activity against gram-positive and -negative bacteria, including staphylococcus aureus and pseudomonas aeruginosa, and 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1h, 5h-be ... | 1989 | 2598310 |
| studies on route of immunization with a mixture of killed parasites and adjuvants against babesia rodhaini infection in mice. | a series of experiments were undertaken to determine the most effective route of immunization with a mixture of killed babesia rodhaini antigen (s antigen) and formalin-fixed corynebacterium parvum (propionibacterium acnes) bacterin (cpb) against challenge infection with b. rodhaini 3 weeks later. the mice pretreated with s antigen and cpb mixture intraperitoneally, but not intramuscularly, were significantly resistant to intraperitoneal (ip) or intravenous (iv) challenge with 10(6) organisms. t ... | 1989 | 2601229 |
| effect of corynebacterium parvum bacterin on artificial immunity against babesia rodhaini infection in mice. | | 1989 | 2601237 |
| effects of synthetic retinoids on the growth of bacteria and their susceptibility to antibiotics. | in patients treated with oral retinoids the recovery of propionibacterium acnes and other anaerobic bacteria in the skin is markedly reduced, whereas an increased colonization of the skin and a significant rise in the incidence of cutaneous staphylococcal infections are observed. since very little is known about the effects of retinoids on bacteria, in the present study we investigated the influence of 4 retinoids (isotretinoin, etretinate, arotinoid ethyl ester, arotinoid sulfone) in 15 differe ... | 1989 | 2614503 |
| propionibacterium acnes endophthalmitis: an unusual manner of presentation. | an unusual clinical presentation of propionibacterium acnes endophthalmitis as a solitary nodule on the corneal endothelial surface at the superior limbus in association with granulomatous uveitis is reported. the patient had previous extracapsular cataract surgery with intraocular lens implantation and two subsequent yag laser capsulotomies. the organism was grown from a microbiopsy of the nodule after a negative anterior chamber tap. the patient was treated with systemic antibiotics, his condi ... | 1989 | 2614715 |
| dissimilatory nitrate reduction by propionibacterium acnes. | propionibacterium acnes p13 was isolated from human feces. the bacterium produced a particulate nitrate reductase and a soluble nitrite reductase when grown with nitrate or nitrite. reduced viologen dyes were the preferred electron donors for both enzymes. nitrous oxide reductase was never detected. specific growth rates were increased by nitrate during growth in batch culture. culture ph strongly influenced the products of dissimilatory nitrate reduction. nitrate was principally converted to ni ... | 1989 | 2624464 |