| a phase one safety study of lactobacillus reuteri conducted in the peruvian amazon: observations from the field. | clinical research on probiotics presents challenging issues for researchers, regulators, and funding agencies, and these issues become more complex when united states federally funded research is conducted outside the united states. here, we describe the design and results of a phase i safety study of lactobacillus reuteri dsm 17938 conducted as a community-based trial under the food and drug administration investigative new drug (fda ind) program in a small town in the peruvian amazon. forty-fi ... | 2014 | 24515943 |
| novel two-component regulatory systems play a role in biofilm formation of lactobacillus reuteri rodent isolate 100-23. | this study characterized the two-component regulatory systems encoded by bfrkrt and cemakr, and assessed their influence on biofilm formation by lactobacillus reuteri 100-23. a method for deletion of multiple genes was employed to disrupt the genetic loci of two-component systems. the operons bfrkrt and cemakr showed complementary organization. genes bfrkrt encode a histidine kinase, a response regulator and an atp-binding cassette-type transporter with a bacteriocin-processing peptidase domain, ... | 2014 | 24509500 |
| selenium effects on the metabolism of a se-metabolizing lactobacillus reuteri: analysis of envelope-enriched and extracellular proteomes. | selenium (se) has received great attention in the last few years, as it is considered to be essential for human health (prevention of viral infections, heart diseases and ageing-related diseases). se deficiency can be counteracted by the administration of selenium-enriched probiotics that are able to convert inorganic selenium into less toxic and more bio-available organic forms. this study was performed on lactobacillus reuteri lb2 bm dsm 16143, a probiotic lab previously demonstrated to be abl ... | 2014 | 24481235 |
| role of lactobacillus reuteri cell and mucus-binding protein a (cmba) in adhesion to intestinal epithelial cells and mucus in vitro. | lactobacillus reuteri, a symbiotic inhabitant of the gastrointestinal tract in humans and animals, is marketed as a probiotic. the ability to adhere to intestinal epithelial cells and mucus is an interesting property with regard to probiotic features such as colonization of the gastrointestinal tract and interaction with the host. here, we present a study performed to elucidate the role of sortase (srta), four putative sortase-dependent proteins (sdps), and one c-terminal membrane-anchored cell ... | 2014 | 24473252 |
| optimisation of oat milk formulation to obtain fermented derivatives by using probiotic lactobacillus reuteri microorganisms. | functional advantages of probiotics combined with interesting composition of oat were considered as an alternative to dairy products. in this study, fermentation of oat milk with lactobacillus reuteri and streptococcus thermophilus was analysed to develop a new probiotic product. central composite design with response surface methodology was used to analyse the effect of different factors (glucose, fructose, inulin and starters) on the probiotic population in the product. optimised formulation w ... | 2015 | 24464238 |
| meta-analysis: lactobacillus reuteri strain dsm 17938 (and the original strain atcc 55730) for treating acute gastroenteritis in children. | lactobacillus reuteri atcc 55730 has been shown to provide a moderate clinical effect in the treatment of acute gastroenteritis (age) in children. however, as the l. reuteri atcc 55730 strain was found to carry potentially transferable resistance traits for tetracycline and lincomycin, it was replaced by a new strain, l. reuteri dsm 17938, without unwanted plasmid-borne antibiotic resistance. bioequivalence of the two strains has been suggested. we aimed to systematically evaluate data on the ef ... | 2014 | 24463209 |
| prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. | infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life and are often responsible for hospitalization, feeding changes, use of drugs, parental anxiety, and loss of parental working days with relevant social consequences. | 2014 | 24424513 |
| probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice. | the decline of circulating testosterone levels in aging men is associated with adverse health effects. during studies of probiotic bacteria and obesity, we discovered that male mice routinely consuming purified lactic acid bacteria originally isolated from human milk had larger testicles and increased serum testosterone levels compared to their age-matched controls. further investigation using microscopy-assisted histomorphometry of testicular tissue showed that mice consuming lactobacillus reut ... | 2014 | 24392159 |
| molecular characterization of host-specific biofilm formation in a vertebrate gut symbiont. | although vertebrates harbor bacterial communities in their gastrointestinal tract whose composition is host-specific, little is known about the mechanisms by which bacterial lineages become selected. the goal of this study was to characterize the ecological processes that mediate host-specificity of the vertebrate gut symbiont lactobacillus reuteri, and to systematically identify the bacterial factors that are involved. experiments with monoassociated mice revealed that the ability of l. reuteri ... | 2013 | 24385934 |
| beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice. | recent studies suggest health benefits including protection from cancer after eating fermented foods such as probiotic yogurt, though the mechanisms are not well understood. here we tested mechanistic hypotheses using two different animal models: the first model studied development of mammary cancer when eating a westernized diet, and the second studied animals with a genetic predilection to breast cancer. for the first model, outbred swiss mice were fed a westernized chow putting them at increa ... | 2014 | 24382758 |
| a simulated mucus layer protects lactobacillus reuteri from the inhibitory effects of linoleic acid. | lactobacillus reuteri is a commensal, beneficial gut microbe that colonises the intestinal mucus layer, where it makes close contact with the human host and may significantly affect human health. here, we investigated the capacity of linoleic acid (la), the most common polyunsaturated fatty acid (pufa) in a western-style diet, to affect l. reuteri atcc pta 6475 prevalence and survival in a simulated mucus layer. short-term (1 h) survival and mucin-agar adhesion assays of a log-phase l. reuteri s ... | 2013 | 24311313 |
| lactobacillus reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial. | to evaluate the effect of oral lactobacillus reuteri (l reuteri) first on the incidence and severity of necrotising enterocolitis (nec) and second on sepsis. | 2014 | 24309022 |
| oral administration of lactobacillus reuteri during the first year of life reduces caries prevalence in the primary dentition at 9 years of age. | the aim of this study was to evaluate the effect on oral health, at age 9 years, of daily oral supplementation with the probiotic lactobacillus reuteri, strain atcc 55730, to mothers during the last month of gestation and to children through the first year of life. the study was a single-blind, placebo-controlled, multicenter trial involving 113 children: 60 in the probiotic and 53 in the placebo group. the subjects underwent clinical and radiographic examination of the primary dentition and car ... | 2014 | 24296746 |
| the influence of stevia glycosides on the growth of lactobacillus reuteri strains. | use of stevia-derived sweeteners was recently officially approved by the european commission, and their application in the food industry has increased, especially in functional foods. however, there are scarce data about the influence of stevia on probiotic bacteria, which are important both as an inhabitant of the human gut and as a functional food additive. taking into consideration the broad application of lactobacillus reuteri in functional foods, the aim of the research was to evaluate the ... | 2014 | 24251876 |
| probiotics for infantile colic: a systematic review. | infantile colic is a common paediatric condition which causes significant parental distress. increased intestinal coliform colonization in addition to alteration in lactobacillus abundance and distribution may play an important role in its pathogenesis. the objectives of this systematic review are to evaluate the efficacy of probiotic supplementation in the reduction of crying time and successful treatment of infantile colic. | 2013 | 24238101 |
| microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. | wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. impact of the microbiome upon the mammalian wound healing process is poorly understood. we discover that supplementing the gut microbiome with lactic acid microbes in drinking water accelerates the wound-healing process to occur in half the time required for matched control animals. further, we find that lactobacillu ... | 2013 | 24205344 |
| clinical and microbiological effects of lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study. | the aim of this randomized placebo-controlled clinical trial was to evaluate the effects of lactobacillus reuteri-containing probiotic lozenges as an adjunct to scaling and root planing (srp). | 2013 | 24164569 |
| lactobacillus reuteri-specific immunoregulatory gene rsir modulates histamine production and immunomodulation by lactobacillus reuteri. | human microbiome-derived strains of lactobacillus reuteri potently suppress proinflammatory cytokines like human tumor necrosis factor (tnf) by converting the amino acid l-histidine to the biogenic amine histamine. histamine suppresses mitogen-activated protein (map) kinase activation and cytokine production by signaling via histamine receptor type 2 (h2) on myeloid cells. investigations of the gene expression profiles of immunomodulatory l. reuteri atcc pta 6475 highlighted numerous genes that ... | 2013 | 24123819 |
| probiotics to prevent or treat excessive infant crying: systematic review and meta-analysis. | importance excessive infant crying is common, distressing, but without proven effective prevention or management options. probiotics may be a promising solution. objective to examine whether probiotics are effective in the prevention/management of crying ("colic") in infants 3 months or younger. data sources a systematic search of medline, embase, and the cochrane library, supplemented by the metaregister of controlled trials. study selection studies that randomized infants 3 months or younger t ... | 2013 | 24100440 |
| enzymatic activity of lactobacillus reuteri grown in a sweet potato based medium with the addition of metal ions. | the effect of metal ions on the enzymatic activity of lactobacillus reuteri was studied. the enzymatic activity was determined spectrophotometrically using the corresponding substrate. in the control group, l. reuteri mf14-c, mm2-3, sd2112, and dsm20016 produced the highest α-glucosidase (40.06 ± 2.80 glu u/ml), β-glucosidase (17.82 ± 1.45 glu u/ml), acid phosphatase (20.55 ± 0.74 ph u/ml), and phytase (0.90 ± 0.05 ph u/ml) respectively. the addition of mg(2+) and mn(2+) led to enhance α-glucosi ... | 2013 | 24083112 |
| improvement of gastrointestinal health status in subjects consuming lactobacillus reuteri ncimb 30242 capsules: a post-hoc analysis of a randomized controlled trial. | gastrointestinal (gi) symptoms are conditions that are frequently observed in clinical practice. a post-hoc analysis has been undertaken to evaluate the effect of bile salt hydrolase-active l. reuteri ncimb 30242 on gi health status based on rome iii questionnaire response in otherwise healthy hypercholesterolemic subjects. | 2013 | 24074303 |
| biotransformation of glycerol to 3-hydroxypropionaldehyde: improved production by in situ complexation with bisulfite in a fed-batch mode and separation on anion exchanger. | 3-hydroxypropionaldehyde (3hpa) is an important c3 chemical that can be produced from renewable glycerol by resting whole cells of lactobacillus reuteri. however the process efficiency is limited due to substrate inhibition, product-mediated loss of enzyme activity and cell viability, and also formation of by-products. complex formation of 3hpa with sodium bisulfite and subsequent binding to amberlite ira-400 was investigated as a means of in situ product recovery and for overcoming inhibition. ... | 2013 | 24060827 |
| probiotics, prebiotics, and dietary fiber in the management of functional gastrointestinal disorders. | at best, currently available therapies provide symptomatic relief from functional gastrointestinal disorders (fgd). no existing therapy, however, can influence the natural course of any of these disorders, prompting interest in new and safe treatment options. this paper summarizes the clinical evidence from randomized controlled trials (rcts) and their meta-analyses of the effectiveness of probiotics, prebiotics, and dietary fiber in the treatment of fgd in the pediatric population. while it is ... | 2013 | 24029785 |
| functional characterization of sucrose phosphorylase and scrr, a regulator of sucrose metabolism in lactobacillus reuteri. | lactobacillus reuteri harbours alternative enzymes for sucrose metabolism, sucrose phosphorylase, fructansucrases, and glucansucrases. sucrose phosphorylase and fructansucrases additionally contribute to raffinose metabolism. glucansucrases and fructansucrases produce exopolysaccharides as alternative to sucrose hydrolysis. l. reuteri lth5448 expresses a levansucrase (ftfa) and sucrose phosphorylase (scrp), both are inducible by sucrose. this study determined the contribution of scrp to sucrose ... | 2013 | 24010626 |
| oral lactobacillus reuteri gmn-32 treatment reduces blood glucose concentrations and promotes cardiac function in rats with streptozotocin-induced diabetes mellitus. | impaired regulation of blood glucose levels in diabetes mellitus (dm) patients and the associated elevation of blood glucose levels are known to increase the risk of diabetic cardiomyopathy (dc). in the present study, a probiotic bacterium, lactobacillus reuteri gmn-32, was evaluated for its potential to reduce blood glucose levels and to provide protection against dc risks in streptozotocin (stz)-induced dm rats. the blood glucose levels of the stz-induced dm rats when treated with l. reuteri g ... | 2014 | 24001238 |
| metabolic fate of ochratoxin a as a coffee contaminant in a dynamic simulator of the human colon. | ochratoxin a (ota) is a mycotoxin frequently encountered in coffee. the relevance of this contaminant in the colon upon digestion necessitates a study on its interaction with colon microbiota. here, the fate of ota during colon digestion was investigated using a dynamic simulator of the human gut. the influence of coffee as a food matrix was taken into account, as it may affect the colonic microbial ecosystem and, consequently, the fate of ota. biodegradation was followed by measuring ota concen ... | 2013 | 23993484 |
| characterization of α-galacto-oligosaccharides formed via heterologous expression of α-galactosidases from lactobacillus reuteri in lactococcus lactis. | α-galacto-oligosaccharides (α-gos) are produced by transgalactosylation reactions of α-galactosidase (α-gal) or by conversion of raffinose family oligosaccharides by levansucrase. similarly to β-gos, α-gos have the potential to mimic glycan receptors on eukaryotic cells and act as molecular decoys to prevent bacterial infection; however, data on transgalactosylation reactions of α-gal remain scarce. the α-gal gene sequence from lactobacillus reuteri was cloned into an α-gal negative strain of la ... | 2014 | 23942880 |
| no effect of probiotics on respiratory allergies: a seven-year follow-up of a randomized controlled trial in infancy. | supplementation with the probiotic lactobacillus reuteri reduced the incidence of ige-associated allergic disease in infancy. this treatment might therefore also reduce the risk of asthma and allergic rhinoconjunctivitis in school age. | 2013 | 23902407 |
| microbial reprogramming inhibits western diet-associated obesity. | a recent epidemiological study showed that eating 'fast food' items such as potato chips increased likelihood of obesity, whereas eating yogurt prevented age-associated weight gain in humans. it was demonstrated previously in animal models of obesity that the immune system plays a critical role in this process. here we examined human subjects and mouse models consuming westernized 'fast food' diet, and found cd4(+) t helper (th)17-biased immunity and changes in microbial communities and abdomina ... | 2013 | 23874682 |
| magnetic chitosan beads for covalent immobilization of nucleoside 2'-deoxyribosyltransferase: application in nucleoside analogues synthesis. | cross-linked magnetic chitosan beads were prepared in presence of epichlorohydrin under alkaline conditions, and subsequently incubated with glutaraldehyde in order to obtain an activated support for covalent attachment of nucleoside 2'-deoxyribosyltransferase from lactobacillus reuteri (lrndt). changing the amount of magnetite (fe(3)o(4)) and epichlorohydrin (epi) led to different macroscopic beads to be used as supports for enzyme immobilization, whose morphology and properties were characteri ... | 2013 | 23832437 |
| gluco-oligomers initially formed by the reuteransucrase enzyme of lactobacillus reuteri 121 incubated with sucrose and malto-oligosaccharides. | the probiotic bacterium lactobacillus reuteri 121 produces a complex, branched (1 → 4, 1 → 6)-α-d-glucan as extracellular polysaccharide (reuteran) from sucrose (suc), using a single glucansucrase/glucosyltransferase (gtfa) enzyme (reuteransucrase). to gain insight into the reaction/product specificity of the gtfa enzyme and the mechanism of reuteran formation, incubations with suc and/or a series of malto-oligosaccharides (moss) (degree of polymerization (dp2-dp6)) were followed in time. the st ... | 2013 | 23804502 |
| direct spray drying and microencapsulation of probiotic lactobacillus reuteri from slurry fermentation with whey. | formulations of dietary probiotics have to be robust against process conditions and have to maintain a sufficient survival rate during gastric transit. to increase efficiency of the encapsulation process and the viability of applied bacteria, this study aimed at developing spray drying and encapsulation of lactobacillus reuteri with whey directly from slurry fermentation. | 2013 | 23795825 |
| salivary iga response to probiotic bacteria and mutans streptococci after the use of chewing gum containing lactobacillus reuteri. | we investigated whether ingestion of probiotic bacteria could influence salivary iga levels, specific anti-mutans streptococci iga levels and specific antibodies towards the ingested probiotic bacterium. the study was a randomised, double-blind, placebo-controlled trial, where the test group (n = 11) received twice daily chewing of gum containing lactobacillus reuteri (2 × 10(8) cfu per dose) and the control group (n = 12) received placebo. resting saliva was collected before and after 12 weeks ... | 2013 | 23737255 |
| privileged incorporation of selenium as selenocysteine in lactobacillus reuteri proteins demonstrated by selenium-specific imaging and proteomics. | an analytical approach was developed to study the incorporation of selenium (se), an important trace element involved in the protection of cells from oxidative stress, into the well-known probiotic lactobacillus reuteri lb2 bm-dsm 16143. the analyses revealed that about half of the internalized se was covalently incorporated into soluble proteins. se-enriched proteins were detected in 2d gels by laser ablation inductively coupled plasma mass spectrometry imaging (la-icp msi) and identified by ca ... | 2013 | 23660472 |
| oral supplementation with probiotic l. reuteri ncimb 30242 increases mean circulating 25-hydroxyvitamin d: a post hoc analysis of a randomized controlled trial. | low serum 25-hydroxyvitamin d is a risk factor for osteoporosis, cardiovascular disease, diabetes, and cancer. disruption of noncholesterol sterol absorption due to cholesterol-lowering therapies may result in reduced fat-soluble vitamin absorption. | 2013 | 23609838 |
| oral administration of lactobacillus reuteri gmnl-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats. | type 2 diabetes mellitus (dm), characterized by peripheral insulin resistance, is the most common form of diabetes. probiotics are live micro-organisms that, when administered in adequate amounts, confer delaying effect on dm development. in this study, the effects lactobacillus reuteri gmnl-263 (lr263), a new probiotic strain developed by our laboratory, on insulin resistance and the development of hepatic steatosis in high-fructose fed rats were explored. furthermore, the relevant regulatory p ... | 2013 | 23590862 |
| metabolism of isomalto-oligosaccharides by lactobacillus reuteri and bifidobacteria. | commercial isomalto-oligosaccharides (imo) are functional food ingredients. they are composed of α(1→6)- and α(1→4)-linked oligosaccharides. imo are partially indigestible, and dietary imo stimulate beneficial members of intestinal microbiota, including lactobacilli and bifidobacteria. however, data on imo metabolism by lactobacilli are not available. it was the aim of this study to identify metabolic pathways of imo metabolism in lactobacilli. this study focused on the host-adapted species lact ... | 2013 | 23565659 |
| pre- and post-natal lactobacillus reuteri supplementation decreases allergen responsiveness in infancy. | we have previously shown that lactobacillus reuteri supplementation from pregnancy week 36 and to the infant through the first year of life decreased the prevalence of ige-associated eczema at 2 years. the underlying immunological mechanisms are unknown, however. | 2013 | 23517039 |
| effects of lactobacillus reuteri pta 5289 and l. paracasei dsmz16671 on the adhesion and biofilm formation of streptococcus mutans. | probiotics have decreased the counts of salivary mutans streptococci (ms) in clinical studies. the aim of this study was to compare the effects of lactobacillus reuteri pta 5289 and l. paracasei dsmz16671 on the adhesion of a reference strain and a clinical isolate of streptococcus mutans and on the counts of ms in a biofilm. the adhesion of s. mutans ingbritt and the clinical isolate s. mutans 2366 to a smooth glass surface and saliva-coated hydroxyapatite (sha) were studied in the presence of ... | 2013 | 23503788 |
| lactobacillus reuteri influences regrowth of mutans streptococci after full-mouth disinfection: a double-blind, randomised controlled trial. | this study assessed whether the persistence of lactobacillus reuteri dsm 17938 and atcc pta 5289 in saliva could delay the regrowth of mutans streptococci (ms) after a full-mouth disinfection with chlorhexidine (chx). a randomised, double-blind, placebo-controlled study with a 6-week intervention period and 3- and 6-month follow-up was performed. 62 healthy subjects with moderate to high counts of ms were randomly assigned to a test group (n = 32) or a placebo group (n = 30). before onset of the ... | 2013 | 23486236 |
| 454 pyrosequencing analysis on faecal samples from a randomized dbpc trial of colicky infants treated with lactobacillus reuteri dsm 17938. | to analyze the global microbial composition, using large-scale dna sequencing of 16 s rrna genes, in faecal samples from colicky infants given l. reuteri dsm 17938 or placebo. | 2013 | 23468874 |
| lactobacillus reuteri dsm 17938 changes the frequency of foxp3+ regulatory t cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis. | necrotizing enterocolitis (nec) is an inflammatory disease of the intestine in premature infants. lactobacillus reuteri dsm 17938 improves survival and reduces the incidence and severity of nec in a rodent model. foxp3(+) regulatory t cells (tregs) maintain intestinal homeostasis by controlling inflammation and inducing tolerance. to determine whether there are insufficient numbers of tregs to control inflammation in nec and to determine if lr17938 increases the frequency of tregs, we studied se ... | 2013 | 23437165 |
| efficacy of orally applied probiotic capsules for bacterial vaginosis and other vaginal infections: a double-blind, randomized, placebo-controlled study. | to assess the efficacy of orally administered capsules containing the probiotics lactobacillus rhamnosus gr-1 and lactobacillus reuteri rc-14 (lactogyn, jgl, rijeka, croatia) compared to placebo in otherwise healthy women diagnosed with bacterial vaginosis. | 2013 | 23395559 |
| probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. | osteoporosis can result from intestinal inflammation, as is seen with inflammatory bowel disease. probiotics, microorganisms that provide a health benefit to the host when ingested in adequate amounts, can have anti-inflammatory properties and are currently being examined to treat inflammatory bowel disease. here, we examined if treating healthy male mice with lactobacillus reuteri atcc pta 6475 (a candidate probiotic with anti-tnfα activity) could affect intestinal tnfα levels and enhance bone ... | 2013 | 23389860 |
| a novel cell modification method used in biotransformation of glycerol to 3-hpa by lactobacillus reuteri. | the aim of the present study was to develop a new cell modification method to facilitate the cell separation from broth. in order to reduce the transfer limitation of substrate and product caused by general immobilization methods in the following biotransformation of glycerol, the carboxyl-functioned superparamagnetic nanoparticle (mnp) was directly attached to the surface of lactobacillus reuteri for 3-hydroxypropionealdehyde producing. the modification process could be finished in several minu ... | 2013 | 23359000 |
| spatiotemporal maps reveal regional differences in the effects on gut motility for lactobacillus reuteri and rhamnosus strains. | commensal bacteria such as probiotics that are neuroactive acutely affect the amplitudes of intestinal migrating motor complexes (mmcs). what is lacking for an improved understanding of these motility effects are region specific measurements of velocity and frequency. we have combined intraluminal pressure recordings with spatiotemporal diameter maps to analyze more completely effects of different strains of beneficial bacteria on motility. | 2013 | 23316914 |
| feeding spinach thylakoids to rats modulates the gut microbiota, decreases food intake and affects the insulin response. | thylakoid membranes derived from green leaf chloroplasts affect appetite-regulating hormones, suppress food intake, reduce blood lipids and lead to a decreased body weight in animals and human subjects. thylakoids also decrease the intestinal in vitro uptake of methyl-glucose in the rat. the aim of this study was to investigate the effect of dietary thylakoids on the gut microbiota composition, mainly the taxa of lactobacilli and bifidobacteria, in rats fed either a thylakoid-enriched diet or a ... | 2013 | 25191569 |
| clinical changes in periodontal subjects with the probiotic lactobacillus reuteri prodentis: a preliminary randomized clinical trial. | the aim of this study was to assess the clinical effect of the administration of lactobacillus reuteri prodentis as a probiotic agent in the treatment of initial to moderate chronic periodontitis. secondary objectives were to evaluate the patient 'compliance' factor and to observe the potential side-effects of the probiotic agent. | 2013 | 23176716 |
| improved production of 3-hydroxypropionaldehyde by complex formation with bisulfite during biotransformation of glycerol. | 3-hydroxypropionaldehyde (3hpa) is an important specialty chemical which can be produced from glycerol using resting cells of lactobacillus reuteri. this biocatalytic route, however, suffers from substrate- and product-mediated loss of enzyme activity within 2 h of biotransformation. in order to overcome the inhibitory effects of 3hpa, complex formation with sodium bisulfite was investigated, optimized and applied for in situ capture of the aldehyde during biotransformation of glycerol in a fed- ... | 2013 | 23172314 |
| substrate channels revealed in the trimeric lactobacillus reuteri bacterial microcompartment shell protein pdub. | lactobacillus reuteri metabolizes two similar three-carbon molecules, 1,2-propanediol and glycerol, within closed polyhedral subcellular bacterial organelles called bacterial microcompartments (metabolosomes). the outer shell of the propanediol-utilization (pdu) metabolosome is composed of hundreds of mainly hexagonal protein complexes made from six types of protein subunits that share similar domain structures. the structure of the bacterial microcompartment protein pdub has a tandem structural ... | 2012 | 23151629 |
| isolation and characterization of novel 1,3-propanediol-producing lactobacillus panis pm1 from bioethanol thin stillage. | conversion of glycerol to 1,3-propanediol (1,3-pdo) is an attractive option to increase the economic efficiency of the biofuel industry. a bacterial strain that produced 1,3-pdo in the presence of glycerol was isolated from thin stillage, the fermentation residue of bioethanol production. this 1,3-pdo-producing organism was identified as lactobacillus panis through biochemical characteristics and by 16s rrna sequencing. characterization of the l. panis strain hereafter designated as pm1 revealed ... | 2013 | 23076589 |
| prophylactic probiotics to prevent death and nosocomial infection in preterm infants. | it has been suggested that probiotics may decrease infant mortality and nosocomial infections because of their ability to suppress colonization and translocation of bacterial pathogens in the gastrointestinal tract. we designed a large double-blinded placebo-controlled trial using lactobacillus reuteri to test this hypothesis in preterm infants. | 2012 | 23071204 |
| lactobacillus reuteri prevents diet-induced obesity, but not atherosclerosis, in a strain dependent fashion in apoe-/- mice. | to investigate whether the specific strains of lactobacillus reuteri modulates the metabolic syndrome in apoe-/- mice. | 2012 | 23056479 |
| lactobacillus reuteri maintains a functional mucosal barrier during dss treatment despite mucus layer dysfunction. | treatment with the probiotic bacterium lactobacillus reuteri has been shown to prevent dextran sodium sulfate (dss)-induced colitis in rats. this is partly due to reduced p-selectin-dependent leukocyte- and platelet-endothelial cell interactions, however, the mechanism behind this protective effect is still unknown. in the present study a combination of culture dependent and molecular based t-rflp profiling was used to investigate the influence of l. reuteri on the colonic mucosal barrier of dss ... | 2012 | 23029509 |
| probiotic lactobacillus reuteri strains atcc pta 5289 and atcc 55730 differ in their cariogenic properties in vitro. | the effects of probiotics on cariogenic biofilms remain controversial. our aim was to characterise two probiotic lactobacillus reuteri strains, atcc pta 5289 and atcc 55730 from a cariogenic standpoint in vitro. these strains are used in commercial products designed for oral health purposes. | 2012 | 23010217 |
| cholesterol lowering and inhibition of sterol absorption by lactobacillus reuteri ncimb 30242: a randomized controlled trial. | the percentage of hypercholesterolemic individuals not reaching their ldl-cholesterol (ldl-c) goal remains high and additional therapeutic strategies should be evaluated. the objective of this study was to evaluate the cholesterol-lowering efficacy and mechanism of action of bile salt hydrolase-active lactobacillus reuteri ncimb 30242 capsules in hypercholesterolemic adults. | 2012 | 22990854 |
| characterization of a small cryptic plasmid pk50-2 isolated from lactobacillus reuteri k50. | the complete nucleotide sequence of a cryptic plasmid, pk50-2, from lactobacillus reuteri k50 had been determined. it consisted of an 1866 bp circular molecule with a g+c content of 35%, from which two putative open reading frames (orfs) could be predicted. based on sequence similarity, the orf1 was not homologous to any known protein, while the n-terminus of the orf2 shared 56% and 64% identities with repb proteins of plasmid par141 and an unnamed plasmid in l. reuteri strain pa-16, members of ... | 2013 | 22982881 |
| lactobacillus reuteri crl1098 soluble factors modulate tumor necrosis factor alpha production in peripheral blood mononuclear cells: involvement of lipid rafts. | the aim of the present study was to evaluate the capacity of lactobacillus reuteri crl1098 soluble factors (lr-s) to modulate tnf-α production in peripheral blood mononuclear cells (pbmc) and to study lipid rafts participation in this response. pbmc treated with lr-s showed a reduced production of tnf-α. in addition, lr-s treatment activated erk and p38 mapk pathways in pbmc. lipid rafts participation in the reduced production of tnf-α by pbmc induced by lr-s was verified by lipid rafts disrupti ... | 2012 | 22982041 |
| lactobacillus reuteri dsm 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial. | to determine whether administration of lactobacillus reuteri (l reuteri) dsm 17938 is beneficial in breastfed infants with infantile colic. | 2013 | 22981952 |
| safety and tolerability of lactobacillus reuteri dsm 17938 and effects on biomarkers in healthy adults: results from a randomized masked trial. | there are few carefully-designed studies investigating the safety of individual probiotics approved under investigational new drug policies. | 2012 | 22970150 |
| effect of routine probiotic, lactobacillus reuteri dsm 17938, use on rates of necrotizing enterocolitis in neonates with birthweight < 1000 grams: a sequential analysis. | necrotizing enterocolitis (nec) is a disease in neonates, often resulting in death or serious medical or neurodevelopmental complications. the rate of nec is highest in the smallest babies and many efforts have been tried to reduce the rate of nec. in neonates born below 1500 grams, the rate of nec has been significantly reduced with the use of various probiotics. this study examines the impact of routine use of a probiotic, lactobacillus reuteri dsm 17938 (biogaia®), on the rate of nec in neona ... | 2012 | 22947597 |
| characterization of a reuterin-producing lactobacillus reuteri bpl-36 strain isolated from human infant fecal sample. | a reuterin (3-hydroxypropinaldehyde, 3-hpa)-producing isolate from a human infant fecal sample was identified as lactobacillus reuteri bpl-36 strain. the organism displayed a broad-spectrum antimicrobial activity. the gene (gdh) encoding a glycerol dehydratase subunit was detected by pcr, thus confirming its reuterin-producing ability. reuterin concentration of 89.63 mm/ml was obtained in the mrs-glycerol medium after 16 h of incubation at 37 °c. the reuterin concentration required to inhibit th ... | 2012 | 26782041 |
| aluminum carboxymethyl cellulose-rice bran microcapsules: enhancing survival of lactobacillus reuteri kub-ac5. | this research aimed to enhance the survival of lactobacillus reuteri kub-ac5 from heat conditioning by using microencapsulation with aluminum carboxymethyl cellulose-rice bran (alcmc-rb) composites of different weight ratios of 1:0, 1:1, and 1:1.5. the cell/polymer suspension was crosslinked with aluminum chloride at different agitation speeds of 1200, 1500, and 2100 rpm. the alcmc microcapsules had significantly higher encapsulation efficiency, but lower microcapsule yield than the alcmc-rb mic ... | 2012 | 24751013 |
| probiotics to improve outcomes of colic in the community: protocol for the baby biotics randomised controlled trial. | infant colic, characterised by excessive crying/fussing for no apparent cause, affects up to 20% of infants under three months of age and is a great burden to families, health professionals and the health system. one promising approach to improving its management is the use of oral probiotics. the baby biotics trial aims to determine whether the probiotic lactobacillus reuteri dsm 17938 is effective in reducing crying in infants less than three months old (<13.0 weeks) with infant colic when com ... | 2012 | 22928654 |
| the effect of cell immobilization on the antibacterial activity of lactobacillus reuteri dpc16 cells during passage through a simulated gastrointestinal tract system. | cell immobilization has the ability to influence the survival and functional characteristics of probiotic bacterial strains in harsh environments. this study investigated the effect of cell immobilization and passage through a simulated gastrointestinal tract (gi) on the antibacterial activity of lactobacillus reuteri dpc16. antibacterial activity, reuterin production and diol dehydratase activity were assayed in recovered isolates of l. reuteri that had been immobilized in ca alginate-skim milk ... | 2012 | 22806742 |
| the effect of immobilization of probiotic lactobacillus reuteri dpc16 in sub-100 μm microcapsule on food-borne pathogens. | the aim of this study was to evaluate whether immobilizing a probiotic strain lactobacillus reuteri dpc16 in chitosan-coated alginate microcapsules affected their inhibitory performance against food-borne pathogens. the probiotic strain was encapsulated in sub-100 μm alginate microspheres which were further coated with chitosan. this type of probiotic microcapsules was investigated in a co-culture model for its effect against two food-borne pathogenic bacteria. the results confirmed the comparab ... | 2012 | 22806120 |
| intestinal origin of sourdough lactobacillus reuteri isolates as revealed by phylogenetic, genetic, and physiological analysis. | lactobacillus reuteri is both a gut symbiont and a stable member of sourdough microbiota. this study employed multilocus sequence analysis and an analysis of host-specific physiological and genetic traits to assign five sourdough isolates to rodent- or human-specific lineages. comparative genome hybridization revealed that the model sourdough isolate lth2584 had a genome content very similar to that of the model rodent isolate 100-23. these results demonstrate that sourdough isolates of l. reute ... | 2012 | 22798372 |
| probiotic effects of orally administered lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. a randomized clinical trial. | to investigate the effects of an orally administered probiotic on the oral microbiota. | 2012 | 22694350 |
| glycerol supplementation enhances l. reuteri's protective effect against s. typhimurium colonization in a 3-d model of colonic epithelium. | the probiotic effects of lactobacillus reuteri have been speculated to partly depend on its capacity to produce the antimicrobial substance reuterin during the reduction of glycerol in the gut. in this study, the potential of this process to protect human intestinal epithelial cells against infection with salmonella enterica serovar typhimurium was investigated. we used a three-dimensional (3-d) organotypic model of human colonic epithelium that was previously validated and applied to study inte ... | 2012 | 22693569 |
| randomised clinical trial: lactobacillus reuteri dsm 17938 vs. placebo in children with acute diarrhoea--a double-blind study. | probiotics may be of help for the management of acute diarrhoea, however, the effect is strain specific and efficacy needs to be proven. | 2012 | 22680836 |
| in vitro and in vivo characterization and strain safety of lactobacillus reuteri ncimb 30253 for probiotic applications. | lactobacillus reuteri ncimb 30253 was shown to have potential as a probiotic by reducing the proinflammatory chemokine interleukin-8. moreover, this strain was evaluated, by in vitro and in vivo techniques, for its safety for human consumption. the identity of the strain was investigated by metabolic profiling and 16s rrna gene sequencing, and in vitro safety evaluations were performed by molecular and metabolic techniques. genetic analysis was confirmed by assessing the minimum inhibitory conce ... | 2012 | 22642667 |
| bacterial species-characteristic profiles of molecular species, and the antigenicity of phospholipids and glycolipids in symbiotic lactobacillus, staphylococcus and streptococcus species. | human symbiotic bacteria, lactobacillus reuteri (lr) in the intestines, staphylococcus epidermidis (se) in skin and streptococcus salivalis (ss) in the oral cavity, contain dihexaosyl diglycerides (dh-dg) in concentrations equivalent to those of phosphatidyl glycerol (pg) and cardiolipin (cl), together with mono- to tetrahexaosyl dgs. the molecular species, as the combination of fatty acids in the dg moiety, were revealed to be bacterial species-characteristic, but to be similar between glycolip ... | 2012 | 22638862 |
| comparative evaluation of three lactobacilli with strain-specific activities for rats when supplied in drinking water. | to test the in vivo benefits of three lactobacilli and to compare their different efficacies based on strain-specific activities by using rats as an experimental model, a growth-promotion and a challenge trial were conducted. the three strains, lactobacillus salivarius g1-1, lactobacillus reuteri g22-2, and lactobacillus reuteri g8-5 shared antimicrobial, bile-salt-hydrolase and amylolytic activities in vitro, respectively. in the 17 day growth-promotion trial, 48 rats were allotted to four trea ... | 2012 | 22622624 |
| levansucrase and sucrose phoshorylase contribute to raffinose, stachyose, and verbascose metabolism by lactobacilli. | raffinose family oligosaccharides (rfos) in food are considered anti-nutritional factors. this study elucidated the role of α-galactosidase (α-gal), levansucrase, and sucrose phosphorylase for conversion of rfos by lactobacilli. quantification of gene expression by reverse-transcriptase quantitative pcr revealed that expression of levansucrase and sucrose phosphorylase by lactobacillus reuteri is increased more than 100 fold when sucrose or raffinose are available. fava bean (vicia faba) or fiel ... | 2012 | 22608234 |
| lactobacillus reuteri protects epidermal keratinocytes from staphylococcus aureus-induced cell death by competitive exclusion. | recent studies have suggested that the topical application of probiotic bacteria can improve skin health or combat disease. we have utilized a primary human keratinocyte culture model to investigate whether probiotic bacteria can inhibit staphylococcus aureus infection. evaluation of the candidate probiotics lactobacillus reuteri atcc 55730, lactobacillus rhamnosus ac413, and lactobacillus salivarius ucc118 demonstrated that both l. reuteri and l. rhamnosus, but not l. salivarius, reduced s. aur ... | 2012 | 22582077 |
| evaluation of clinical safety and tolerance of a lactobacillus reuteri ncimb 30242 supplement capsule: a randomized control trial. | a significant number of human clinical trials have reported no adverse effects associated with consumption of lactobacillus reuteri (l. reuteri). in the present study, the clinical safety and toxicology of oral ingestion of supplement capsules containing l. reuteri ncimb 30242 was investigated. a randomized group of 131 subjects received a dose of 2.9×10⁹ cfu l. reuteri ncimb 30242 capsules (n=67) or placebo capsules (n=64) twice daily for 9 weeks. clinical chemistry and hematological parameters ... | 2012 | 22561556 |
| development of a potential functional food prepared with pigeon pea (cajanus cajan), oats and lactobacillus reuteri atcc 55730. | the purpose of this study was to investigate the survival of lactobacillus reuteri atcc 55730 in creams, prepared with pigeon peas and oat. products were analysed to determine their content of protein, fibre, fat, carbohydrates and degree of likeness. viable numbers of l. reuteri and ph were determined after 1, 7, 14, 21 and 28 days of storage at 4°c. results showed significant differences (p < 0.05) in protein, fat, fibre and carbohydrate content between creams. no significant differences (p > ... | 2012 | 22533458 |
| the effect of lactobacillus reuteri on bone morphogenetic protein-7 and beta transforming growth factor gene expressions in streptozotocin-induced diabetic rat's kidneys. | diabetes mellitus is a serious health problem in the world and about 20 to 40% of the patients are being affected with diabetic nephropathy. the anti diabetic property of lactobacillus reuteri (l. reuteri) has been reported. the study designed to investigate the effect of l. reuteri on the expression of bmp-7 and tgf-beta genes, the two basic factors involved in diabetic nephropathy. this experimental study was carried out in two months. for this goal thirty male wistar rats with 12 weeks old an ... | 2012 | 24199466 |
| spectroscopic characterization of active-site variants of the pduo-type atp:corrinoid adenosyltransferase from lactobacillus reuteri: insights into the mechanism of four-coordinate co(ii)corrinoid formation. | the pduo-type adenosine 5'-triphosphate (atp):corrinoid adenosyltransferase from lactobacillus reuteri (lrpduo) catalyzes the transfer of the adenosyl-group of atp to co(1+)cobalamin (cbl) and co(1+)cobinamide (cbi) substrates to synthesize adenosylcobalamin (adocbl) and adenosylcobinamide (adocbi(+)), respectively. previous studies revealed that to overcome the thermodynamically challenging co(2+) → co(1+) reduction, the enzyme drastically weakens the axial ligand-co(2+) bond so as to generate ... | 2012 | 22480351 |
| probiotic supplements (lactobacillus reuteri dsm 17938 and atcc pta 5289) do not affect regrowth of mutans streptococci after full-mouth disinfection with chlorhexidine: a randomized controlled multicenter trial. | the aim of this study was to investigate the effectiveness of tablets containing two probiotic lactobacillus reuteri strains in inhibiting regrowth of salivary mutans streptococci (ms) after full-mouth disinfection (fmd) with chlorhexidine. the null hypothesis was that the levels of ms would not differ in comparison with a placebo protocol. the study population was comprised of 62 young adults (mean age 23 years) with moderate or high counts of salivary ms who volunteered after informed consent. ... | 2012 | 22472585 |
| design of a specific colonic mucus marker using a human commensal bacterium cell surface domain. | imaging living cells and organs requires innovative, specific, efficient, and well tolerated fluorescent markers targeting cellular components. such tools will allow proceeding to the dynamic analysis of cells and the adaptation of tissues to environmental cues. in this study, we have identified and synthesized a novel non-toxic fluorescent marker allowing a specific fluorescent staining of the human colonic mucus. our strategy to identify a molecule able to specifically bind to the human coloni ... | 2012 | 22427651 |
| evaluation of safety and tolerance of microencapsulated lactobacillus reuteri ncimb 30242 in a yogurt formulation: a randomized, placebo-controlled, double-blind study. | probiotic organisms have shown promise in treating diseases. previously, we have reported on the efficacy of microencapsulated lactobacillus reuteri ncimb 30242 in a yogurt formulation at lowering serum cholesterol levels in otherwise healthy hypercholesterolemic adults. this study investigates the safety and toxicology of oral ingestion of microencapsulated l. reuteri ncimb 30242 in a yogurt formulation. a randomized group of 120 subjects received a dose of 5 × 10(10) cfu microencapsulated l. r ... | 2012 | 22425689 |
| implantation ability of the potential probiotic strain, lactobacillus reuteri pl519, in "salchichón," a traditional iberian dry fermented sausage. | the purpose of this study was to investigate the potential of incorporating the probiotic l. reuteri pl519 into the manufacturing of iberian dry fermented sausages, and to observe its effect on the sensory properties of these meat products. specific polymerase chain reaction (pcr) was carried out to detect the presence of probiotic strain at high counts in the inoculated sausages. changes due to probiotic inoculation on physicochemical parameters were determined and the impact on sensory quality ... | 2016 | 22417437 |
| characterization of lactic acid bacteria-based probiotics as potential heavy metal sorbents. | to isolate and characterize lactic acid bacteria (lab) and determine whether they could potentially be used as heavy metal (cadmium and lead) absorbing probiotics. | 2012 | 22404232 |
| histamine derived from probiotic lactobacillus reuteri suppresses tnf via modulation of pka and erk signaling. | beneficial microbes and probiotic species, such as lactobacillus reuteri, produce biologically active compounds that can modulate host mucosal immunity. previously, immunomodulatory factors secreted by l. reuteri atcc pta 6475 were unknown. a combined metabolomics and bacterial genetics strategy was utilized to identify small compound(s) produced by l. reuteri that were tnf-inhibitory. hydrophilic interaction liquid chromatography-high performance liquid chromatography (hilic-hplc) separation is ... | 2012 | 22384111 |
| [which treatments for infantile colics?]. | infantile colics or excessive crying represent a source of stress for parents and a frequent reason for encounter in primary care. | 2012 | 22365343 |
| characterization of intestinal lactobacillus reuteri strains as potential probiotics. | this study was conducted to evaluate the probiotic properties of lactobacillus reuteri isolated from human infant feces (less than 3 months). out of thirty-two representative l. reuteri strains isolated from the infant human feces, nine isolates (i.e. lr5, lr6, lr9, lr11, lr19, lr20, lr25, lr26 and lr34) showed survival in acid, bile and simulated stomach-duodenum passage conditions, indicating their high tolerance to gastric juice, duodenal juice and bile environments. the nine isolates did not ... | 2012 | 26781736 |
| lactobacillus reuteri crl 1101 highly produces mannitol from sugarcane molasses as carbon source. | mannitol is a natural polyol extensively used in the food industry as low-calorie sugar being applicable for diabetic food products. we aimed to evaluate mannitol production by lactobacillus reuteri crl 1101 using sugarcane molasses as low-cost energy source. mannitol formation was studied in free-ph batch cultures using 3-10% (w/v) molasses concentrations at 37 °c and 30 °c under static and agitated conditions during 48 h. l. reuteri crl 1101 grew well in all assayed media and heterofermentativ ... | 2012 | 22350320 |
| host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice. | beneficial microbes and probiotics are promising agents for the prevention and treatment of enteric and diarrheal diseases in children; however, little is known about their in vivo mechanisms of action. we used a neonatal mouse model of rotavirus diarrhea to gain insight into how probiotics ameliorate acute gastroenteritis. | 2012 | 22343914 |
| influence of in-situ synthesized exopolysaccharides on the quality of gluten-free sorghum sourdough bread. | the majority of gluten-free breads on the market are of poor sensory and textural quality. exopolysaccharides (eps) formed from sucrose during sourdough fermentation can improve the technological properties of gluten-free breads and potentially replace hydrocolloids. in this study, the influence of in situ formed eps on dough rheology and quality of gluten-free sorghum bread was investigated. dextran forming weissella cibaria mg1 was compared to reuteran producing lactobacillus reuteri vip and f ... | 2012 | 22342455 |
| lack of an effect of lactobacillus reuteri dsm 17938 in preventing nosocomial diarrhea in children: a randomized, double-blind, placebo-controlled trial. | to evaluate the efficacy of administering lactobacillus reuteri dsm 17938 for the prevention of nosocomial diarrhea. | 2012 | 22306046 |
| transcriptional and metabolomic consequences of luxs inactivation reveal a metabolic rather than quorum-sensing role for luxs in lactobacillus reuteri 100-23. | autoinducer-2 (ai-2)-mediated quorum sensing has been extensively studied in relation to the regulation of microbial behavior. there are, however, two potential roles for the ai-2 synthase (luxs). the first is in the production of ai-2 and the second is as an enzyme in the activated methyl cycle, where it catalyzes the conversion of s-ribosylhomocysteine to homocysteine. the by-product of the reaction catalyzed by luxs is (s)-4,5-dihydroxy-2,3-pentanedione, which spontaneously forms the furanone ... | 2012 | 22287522 |
| molecular characterisation and biomass and metabolite production of lactobacillus reuteri lpb p01-001: a potential probiotic. | lactobacillus reuteri lpb p01-001 was isolated from the gastrointestinal tract of wild swine and was characterised by biochemical testing and sequencing of gene 16s rrna. a simple and low-cost culture medium based on cane sugar (2.5% p/v) and yeast extract (1% p/v) was used in the production of this probiotic. the fermentative conditions were a) ph control at 6.5 and b) no ph control; both were set at 37°c in a 12 l slightly stirred tank bioreactor. fermentation parameters such as the specific g ... | 2012 | 24031812 |
| a novel delivery system of probiotic drop and its effect on dental caries risk factors in cleft lip/palate children. | the aim of the present study was to investigate the effect of the probiotic bacterium lactobacillus reuteri on the levels of salivary mutans streptococci and lactobacilli in children with cleft lip/palate who used the novel drop containing l. reuteri. | 2012 | 21309653 |
| comparative evaluation of probiotics effects on plasma glucose, lipid, and insulin levels in streptozotocin-induced diabetic rats. | diabetes is a chronic disorder caused by the relative decrease in insulin production from the pancreas, tissue resistance to insulin, or both. daily consumption of probiotics, particularly lactobacilli, has been proposed as a new strategy for prevention or control of diabetes. | 2017 | 28608654 |
| diabetes-associated microbiota in fa/fa rats is modified by roux-en-y gastric bypass. | roux-en-y gastric bypass (rygb) and duodenal jejunal bypass (djb), two different forms of bariatric surgery, are associated with improved glucose tolerance, but it is not clear whether the gut microbiota contributes to this effect. here we used fa/fa rats as a model of impaired glucose tolerance to investigate whether (i) the microbiota varies between fa/fa and nondiabetic fa/+ rats; (ii) the microbiota of fa/fa rats is affected by rygb and/or djb; and (iii) surgically induced microbiota alterat ... | 2017 | 28524868 |
| gut microbial transformation of the dietary imidazoquinoxaline mutagen meiqx reduces its cytotoxic and mutagenic potency. | the diverse community of microbes present in the human gut has emerged as an important factor for cancer risk, potentially by altering exposure to chemical carcinogens. in the present study, human gut bacteria were tested for their capacity to transform the carcinogenic heterocyclic amine 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (meiqx). eubacterium hallii, lactobacillus reuteri, and lactobacillus rossiae were able to convert meiqx to a new microbial metabolite characterized on the basis of ... | 2017 | 28666384 |
| control of lupus nephritis by changes of gut microbiota. | systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. immunosuppressants used in treatment put patients at a higher risk of infections. new knowledge of disease modulators, such as symbiotic bacteria, can enable fine-tuning of parts of the immune system, rather than suppressing it altogether. | 2017 | 28697806 |
| analysis of antimicrobial and immunomodulatory substances produced by heterofermentative lactobacillus reuteri. | antimicrobial and immunomodulatory potential of various lactobacillus reuteri strains is closely connected to their metabolite production profile under given cultivation conditions. we determined the in vitro production of antimicrobial substances such as organic acids, ethanol, and reuterin by four strains of l. reuteri (l. reuteri e, l. reuteri ko5, l. reuteri ccm 3625, and l. reuteri atcc 55730). all studied l. reuteri strains showed the ability to produce lactic acid, acetic acid, and ethano ... | 2017 | 28401403 |
| gut microbiota mediated benefits of barley kernel products on metabolism, gut hormones, and inflammatory markers as affected by co-ingestion of commercially available probiotics: a randomized controlled study in healthy subjects. | barley kernel based products have been shown to induce benefits on blood glucose regulation, cardio-metabolic risk markers and appetite regulating hormones in a time perspective of 11-16 h after intake. the mechanisms have been assigned to gut fermentation of indigestible carbohydrates. the purpose of the present study was to evaluate if the modulatory effects of barley on markers of metabolic- and appetite regulation are affected by a dietary background including a mixture of commercially avail ... | 2016 | 28531784 |