| [a penicillinase forming strain of gonococcus isolated in rotterdam]. | | 1977 | 404576 |
| penicillin-resistant strains of neisseria gonorrhoeae in shahre-now. | of 921 women examined, 112, or 12.1%, were identified as having gonorrhoea by positive culture; 25.6% of 78 strains isolated from the women were resistant to penicillin at 0.10 mug/ml level and 14.1% resistant at the 0.50 mug/ml level as determined by an agar dilution mic test. our results were compatible with a similar but larger study reported in the usa by jaffe et al. 1976. | 1977 | 404740 |
| an indirect haemagglutination test for demonstration of gonococcal antibodies using gonococcal pili as antigen. i. methodology and preliminary results. | an indirect haemagglutination (iha) test for detection of gonococcal antibodies in human sera was established using purified pili as antigen. the majority of sera (44/51), positive in the gonococcal complement fixation test, were also positive in the iha test with titres within the range 320-10,000. the results obtained for the following three groups of sera indicate a comparatively high speicificity of the iha test; 1) 52 sera from children below 12 years of age were all negative, 2) 98% (184/1 ... | 1977 | 404842 |
| group y meningococcal disease in united states air force recruits. | between 1971 and 1974, group y meningococcal disease developed in 88 air force recruits; 68 had primary bacterial pneumonia. none of the patients with primary pneumonia had the stigmata of meningococcemia or meningitis. patients with pneumonia responded well to small doses of parenteral penicillin. ten patients had meningococcemia, and six had meningitis. pneumonia, therefore, predominated over meningococcemia and meningitis 4:1. skin lesions were rare in patients with meningococcemia but freque ... | 1977 | 404877 |
| comparative trial of carbenicillin and ampicillin therapy for purulent meningitis. | a randomized therapeutic trial of carbenicillin (cb) or ampicillin (amp) in purulent meningitis was performed in 86 pediatric and adult patients (41 haemophilus influenzae, 22 streptococcus pneumoniae, 13 neisseria meningitidis, and 10 of unknown etiology). all isolates, incuding h. influenzae, were susceptible to cb and amp. median cerebrospinal fluid (csf) antibiotic concentrations were 0.85 and 1.60 mug/ml for cb and amp, respectively, during administration of daily doses of 400 mg/kg and 0.6 ... | 1977 | 404962 |
| plasmid-mediated beta-lactamase production in neisseria gonorrhoeae. | several beta-lactamase-producing, penicillin-resistant strains of neisseria gonorrhoeae were examined for r plasmids. penicillin-resistant strains isolated from men returning from the far east and their contacts contained a 4.4 x 10(6)-dalton plasmid in common. transformation studies and the isolation of a spontaneous penicillin-susceptible segregant showed that the structural gene for beta-lactamase was part of the 4.4 x 10(6)-dalton plasmid. an additional penicillin-resistant gonococcal strain ... | 1977 | 404964 |
| characterization of meningococcal polysaccharides by optical mixing spectroscopy. ii. effects of temperature, edta, and ionic strength on aggregation of group c polysaccharides in solution. | | 1977 | 405053 |
| test antiserum for group b meningococci. | | 1977 | 405072 |
| isolation of 9-o-(alpha-d-n-acetylneuraminyl)-beta-d-n-acetylneuraminic acid by partial acid hydrolysis, and its characterisation by 13c n.m.r. | | 1977 | 405102 |
| [neisseria gonorrhoeae culture: development of an easy method]. | an easy and cheap method for culturing neisseria is developed. the medium for gonococci is prepared as proposed by the producer (bbl, oxoid, hoechst). about 8 ml of the medium are poured in sterile air-tight stool tubes of 25 ml volume. materials to be examined for gonococci are taken from the cervix, ureter or anus and are inoculated on the medium. a small piece (20-30 mg) of the gaspak tablet (bbl) is then deposited in the tube and closed immediately. the gaspak tablet consists of sodium bicar ... | 1977 | 405261 |
| lipopolysaccharide serotyping of neisseria meningitidis by hemagglutination inhibition. | the method of hemagglutination inhibition was used to investigate the antigenic diversity of lipopolysaccharide (lps) from neisseria meningitidis and to develop a serotyping systems based on this antigen. the system uses outer membrane complex prepared by a simple extraction procedure to inhibit homologous hemagglutination reactions involving sheep erythrocytes sensitized with purified lps and rabbit antiserum raised to whole meningococci. antisera with specificity for eight different lps determ ... | 1977 | 405320 |
| composition of the lipopolysaccharide of neisseria gonorrhoeae. | analysis of glycose and fatty acid content of lipopolysaccharide extracted from 38 strains of neisseria gonorrhoeae indicated that glycoses common to colonial types 1 to 5 were glucose, mannose, and galactose, n-acetylneuraminic acid, 2-keto-3-deoxyoctulosonic acid (kdo), glucosamine, and galactosamine were also invariably present. virulent colonial types 1 and 2 contained no rhamnose, in contrast to avirulent types 3 to 5 and several strains of the nonpathogenic species n. sicca and n. lactamic ... | 1977 | 405323 |
| chicken embryo as an animal model for gonorrhea. | parameters of infection of the chicken embryo with neisseria gonorrhoeae were defined in order to standardize infectious and lethal doses. virulent (t1) and avirulent (t3) gonococci from two strains were used to infect 7- to 12-day-old white leghorn chicken embryos via the yolk sac (ys) or chorioallantoic membrane (cam) route. infection of embryos was established following ys inoculation of 1 to 10 viable gonococci. although 8- to 10-day-old embryos were the most susceptible, an inoculum of less ... | 1977 | 405324 |
| homogeneity of protein serotype antigens in neisseria meningitidis group a. | serotype antigens (sta), which have been shown to be constituents of outer-membrane protein, were extracted from group a meningococci with 0.2 m licl and pelleted by centrifugation at 150,000 x g. the stas from 100 group a strains, which had been isolated from cases and carriers in various geographical locations, were compared by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page). every sta produced three major protein bands with molecular weights of approximately 35,000, 39,00 ... | 1977 | 405327 |
| variations in buccal cell adhesion of neisseria gonorrhoeae. | human buccal cells were found to vary in their day-to-day capacity to support attachment of certain strains of gonococci. gonococci serially cultured in vitro also differed in their day-to-day ability to attach to buccal cells. | 1977 | 405329 |
| immunity to gonococcal infection induced by vaccination with isolated outer membranes of neisseria gonorrhoeae in guinea pigs. | purified outer membranes from neisseria gonorrhoeae strain m or b were prepared. gonococcal outer membranes were pure as evidenced by banding insucrose gradients at a density of 1.23 g/cm3, simple protein composition patterns when analysed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, low succinic dehydrogenase levels, and few precipitin peaks obtained in two-dimensional immuno-electrophoresis against hyperimmune serum to gonococcal sonicates. isolated outer membranes administere ... | 1977 | 405431 |
| treatment of gonorrhea with trimethoprim-sulfamethoxazole. | the following regimens were randomly administered to 271 men with gonococcal urethritis: 4.8 x 10(6) units of aqueous procaine penicillin g intramuscularly plus 1 g of probenecid orally (appg); nine tablets of trimethoprim-sulfamethoxazole (tmp-smz; 720 mg of tmp and 3,600 mg of smz), orally as a single dose (tmp-smz-9); and 12 tablets of tmp-smz (960 mg of tmp and 4,800 mg of smz) orally as two doses of six tablets taken at a 6-hr interval (tmp-smz-12). the failure rates of the appg, tmp-smz-9, ... | 1977 | 405433 |
| the development of l-phase colonies for neisseria gonorrhoeae. | | 1977 | 405456 |
| [venerology in the everyday work of the internist]. | the worldwide increase in the incidence of sexually transmitted diseases confronts the physician to an increasing extent with this group of infections. the high morbidity and the change in the clinical picture of gonorrhea, especially its asymptomatic form, give rise to extragenital complications which frequently lead the patient to the internal specialist in the first instance. non-gonorrheal urethritis, in particular the infectious form, is undergoing intensive research. a number of organisms ... | 1977 | 405739 |
| asymptomatic gonorrhea in men: caused by gonococci with unique nutritional requirements. | in a retrospective case-control study, gonococci with nutritional requirements for arginine, hypoxanthine, and uracil were recovered from 24 of 25 men with asymptomatic gonorrhea and 10 of 25 men with symptomatic gonorrhea (p = .0001). these strains represent a smaller proportion of gonococcal isolate from blacks than from whites. asymptomatic urethral infection is important in the epidemiology of gonorrhea, particularly among whites. | 1977 | 405742 |
| penicillinase-producing neisseria gonorrhoeae. | | 1977 | 405745 |
| penicillinase-producing neisseria gonorrhoeae. | | 1977 | 405746 |
| [experience with the serological diifferentiation of meningococci]. | | 1977 | 405798 |
| control of penicillinase-producing gonococci. | | 1977 | 405999 |
| penicillin-resistant gonococci. | | 1977 | 406004 |
| detection and identification of gonococcal l-forms using a direct immunofluorescence test. | a fluorescent antibody test was used to identify l-forms of n. gonorrhoeae induced in vitro. it was possible to differentiate the large bodies of the l-forms from parent gonococci and the fluorescent reaction remained specific in the presence of tissue culture cells. a possible method to identify l-forms of gonococci from patients presenting with postgonococcal urethritis is described. | 1977 | 406010 |
| problems posed by potential gonococcal vaccines viewed from the vantage point of a control agency. | progress in the characterisation of neisseria gonorrhoeae and other bacterial pathogens has suggested that immunoprophylaxis for gonorrhoea may be possible despite the well-known propensity for reinfection. pili, outer membrane proteins, a capsular polysaccharide, and the lipopolysaccharide may be important gonococcal virulence factors, and immune components (probably antibodies) to more than one of these antigens may be required to confer immunity. a study of antigenic polymorphism of these str ... | 1977 | 406011 |
| binding of progesterone to neisseria gonorrhoeae and other gram-negative bacteria. | the binding of [1,2-(3)h]progesterone to progesterone-sensitive neisseria gonorrhoeae cs-7 and the progesterone-insensitive neisseria mucosa, pseudomonas aeruginosa, and salmonella typhimurium (rough and smooth strains) was investigated. the kinetics of binding to n. gonorrhoeae cs-7 demonstrated that the majority of the progesterone binding occurred and equilibrium was reached within the first 30 min. despite the rapid binding of progesterone, only about 20% of the added steroid was bound at th ... | 1977 | 406199 |
| pathology in rabbits treated with leukocyte-degraded meningococci in combination with meningococcal endotoxin. | the effects of a preparative dose of the leukocyte egesta containing degraded meningococci and a provocative dose of the meningococcal lipopolysaccharide on development of pathological lesions associated with disseminated intravascular coagulation were studied in tissues of 32 rabbits. these effects were compared with effects of a single dose of meningococcal lipopolysaccharide as well as leukocyte egesta containing degraded staphylococcus epidermidis. rabbits injected subcutaneously with egesta ... | 1977 | 406202 |
| stability of working reagents for the modified rapid fermentation test (mrft). | the modified rapid fermentation test (mrft) for neisseria gonorrhoeae has been shown to demonstrate the proper carbohydrate degradation for confirmation in less than 30 minutes. a new approach for using the reagents in the testing procedure has been established, making the mrft a more practical tool in the laboratory. instead of mixing reagents at the time of testing, previously prepared, labelled reagents were made in economic quantities and used according to the established procedure. these pr ... | 1977 | 406221 |
| selection from gonococci grown in vitro of a colony type with some virulence properties of organisms adapted in vivo. | gonococci from subcutaneously implanted chambers in guinea pigs produced, on agar, more than 95% small colonies showing a "double highlight" (dh) effect in oblique reflected light combined with transmitted light. laboratory strains of gonococci produced some dh colonies, but other showed a single highlight (sh) or no highlight (nh). selection of dh colonies and comparison of their organisms with gonococci grown in vivo and with those from sh colonies, showed that the dh character was associated ... | 1977 | 406351 |
| immunization of guinea pigs with neisseria gonorrhoeae: strain specificity and mechanisms of immunity. | infection of subcutaneusly implanted chambers in guinea pigs conferred immunity against homologous infection of other chambers in the same animals. however, attempts to immunize guinea pigs by subcutaneous injection of filtered fluid from infected chambers, or with small doses of formalin-killed, chamber gonococci were not successful. thus, neither organisms grown in vivo nor their extracellular products appeared to be exceptionally immunogenic. in immunizing tests with different isolates of gon ... | 1977 | 406352 |
| the surface of neisseria gonorrhoeae: isolation of the major components of the outer membrane. | outer membranes were isolated from several strains of neisseria gonorrhoeae by extraction of whole cells with aqueous lithium acetate. the preparations contained a limited number of components including lipopolysaccharide and two major proteins. one protein was present in all strains examined; the second, which showed anomalous behaviour on sodium dodecyl sulphate-polyacrylamide gel electrophoresis, was absent from some. fluorescent labelling of intact n. gonorrhoeae showed that the two proteins ... | 1977 | 406355 |
| diagnosis and treatment of acute salpingitis. | acute salpingitis is one of the most common acute gynecologic diseases and occurs in approximately 750,000 women each year in the united states. use of laparoscopy to confirm the diagnosis of acute salpingitis has shown that the signs and symptoms classically ascribed to this disease are not specific to it. fever, leukocytosis, elevated esr and adnexal masses or swelling are not necessary to make a diagnosis of acute salpingitis. lower abdominal pain and adnexal tenderness are the most consisten ... | 1977 | 406388 |
| the role of gonococcus in salpingitis. | | 1977 | 406390 |
| penicillin-resistant gonococci in perspective. | | 1977 | 406415 |
| [evaluation of lc medium in the diagnosis of gonococcal infection among street prostitutes]. | | 1977 | 406434 |
| is it gonorrhea...or "non-specific" urethritis? | | 1977 | 406495 |
| penicillinase-producing strain. | | 1977 | 406503 |
| [subinhibitory concentrations of antibiotics. effects on morphology and growth (author's transl)]. | experiments with subinhibitory concentrations of antibiotics revealed certain effects that had not been observed at higher concentrations. two different effects are described: morphological changer and inhibition of growth. the expression minimum antibiotic concentration (mac) has been shown to be of both theoretical and practical value. it has served to make plain the differences between the effects of various antibodies that were not observed at the mic. the ratio mac/mic could be be of import ... | 1977 | 406590 |
| primary meningococcal conjunctivitis. | | 1977 | 406593 |
| urethritis in white men--a microbiological appraisal. | the incidence of infections with neisseria gonorrhoeae, chlamydia trachomatis and mycoplasmas has been assessed in white men with urethritis who were attending a johannesburg clinic for sexually transmitted diseases. infection with n. gonorrhoeae was demonstrated in 54% of 212 patients with urethritis. c. trachomatis was isolated from 37% of patients with non-gonococcal urethritis, and from 25% with proven gonococcal infection. although t-mycoplasmas were isolated significantly more often from p ... | 1977 | 406683 |
| [rate of gonococcus isolation in gonorrhea recurrence in women]. | | 1977 | 406750 |
| a civilian case of fatal meningococcemia due to neisseria meningitidis, group y. | the present report is that of a civilian episode of fatal, fulminant group y meningococcemia in a previously healthy adolescent, who denied prior vaccination against group c meningococcus. the patient suffered abrupt onset of purpura, hypotension and cardiopulmonary arrest. a detailed clinical and pathologic report is included. | 1977 | 406780 |
| culture and treatment results in endometritis following elective abortion. | endometrial culture and treatment results from 228 patients who developed endometritis following elective abortion were analyzed. the most common organisms isolated were group b beta hemolytic streptococci, bacteroides, neisseria gonorrhoeae, e. coli, and staphylococcus aureus. in general, patients responded to treatment with penicillin or ampicillin, with the addition of an aminoglycoside for these requiring hospitalization. curettage was an important adjunctive treatment for hospitalized patie ... | 1977 | 406787 |
| transfer of beta-lactamase genes of neisseria gonorrhoeae by conjugation. | recent isolates of neisseria gonorrhoeae have been shown to be resistant to penicillin because they produce beta-lactamase. in this study, conjugal transfer of the beta-lactamase gene to a recipient n. gonorrhoeae strain occurred in one of the two strains studied but not in the other. the transconjugant could also conjugally transfer the beta-lactamase gene to an escherichia coli strain. | 1977 | 406833 |
| rapid penicillinase paper strip test for detection of beta-lactamase-producing haemophilus influenzae and neisseria gonorrhoeae. | a modified 1-min iodometric paper strip test for penicillinase activity was developed for detection of beta-lactamase-producing isolates of haemophilus influenzae and neisseria gonorrhoeae. the test is simple to perform and uses reagent-impregnated strips that may be stored for 1 year or more prior to use. | 1977 | 406836 |
| loss of antibody activity in human immunoglobulin a exposed extracellular immunoglobulin a proteases of neisseria gonorrhoeae and streptococcus sanguis. | immunoglobulin a (iga) proteases are extracellular enzymes elaborated by neisseria gonorrhoeae, n. meningitidis, and streptococcus sanguis. these enzymes each cleave human iga1 at a critically situated prolyl-threonyl peptide bond to yield fab alpha and fc alpha fragments. to study their effect on the antibody activity of human iga, we enzymatically digested a group of five human iga monoclonal immunoglobulins with high-titer rheumatoid factor or cold agglutinin activity and human serum macroamy ... | 1977 | 407159 |
| molecular characterization of two beta-lactamase-specifying plasmids isolated from neisseria gonorrhoeae. | the molecular nature of two distinct gonococcal r plasmids, 4.4 x 10(6) and 3.2 x 10(6) daltons, encoding beta-lactamase activity were examined. both plasmids contained about 40% of the transposable ampicillin resistance sequence tn2. deoxyribonucleic acid-deoxyribonucleic acid polynucleotide sequence studies have shown that the two gonococcal plasmids share about 70% of their sequences and are closely related to rsf0885, a 4.1 x 10(6)-dalton plasmid found in a beta-lactamase-producing strain of ... | 1977 | 407214 |
| an epidemic of disease due to serogroup b neisseria meningitidis in alabama: report of an investigation and community-wide prophylaxis with a sulfonamide. | an epidemic of disease due to sulfonamide-sensitive serogroup b neisseria meningitidis occurred in 1975-1976 in southwestern alabama. ten cases occurred in a circumscribed area and resulted in an annual attack rate of 20 cases per 100,000 population. none of the cases were in siblings, and none of the patients had had direct contact with each other. a case-control household study suggested that crowding and person-to-person transmission via carriers may have been contributing risk factors. seven ... | 1977 | 407309 |
| perihepatitis and hepatitis as complications of experimental endocarditis due to neisseria gonorrhoeae in the rabbit. | seven strains of neisseria gonorrhoeae (colony type 1 or 2) were tested for their ability to produce endocarditis in rabbits with transaortic valve catheters. the gonococci exhibited three auxotype patterns and a broad range of susceptibility to penicillin and to complement-mediated serum bactericidal activity. only four strains produced endocarditis; infectivity appeared to be related to serum resistance. neither arthritis nor skin lesions were observed in infected animals, but 40% had hepatiti ... | 1977 | 407313 |
| gonorrhea screening in male consorts of women with pelvic infection. | neisseria gonorrhoeae was isolated from 39% of male contacts of women with acute gonococcal pelvic inflammatory disease (pid); 22% of these men were asymptomatic. more than half of those women with gonococcal pid had at least one male sexual consort with gonorrhea. neisseria gonorrhoeae was isolated from 15% of male contacts of women with nongonococcal pid; 30% were asymptomatic. since a substantial number of male contacts of women with acute pid will have cultures positive for n gonorrhoeae and ... | 1977 | 407378 |
| [a meningococcal epidemic in ankara]. | the meningococcal meningitis epidemic has been observed in ankara in the last 3 years. cases were from all parts of the country. most of the strains isolated were from group b, while many could not be classified, and some of them were from group c, a and d. because of fewer cases from group a and more from group b and c, the epidemic was not the classical meningococcal meningitis, but an intermediate one. many cases could not be classified with the classical a, b, c, and d antisera. this showed ... | 1977 | 407430 |
| [the importance of asymptomatic urethral gonorrhea in men]. | | 1977 | 407482 |
| [problems of microbiological diagnosis in gonorrhea]. | | 1977 | 407735 |
| [bordet-gengou and hemagglutination reactions with a new antigen in gonorrhea]. | | 1977 | 407740 |
| pathogenesis of acute pelvic inflammatory disease: role of contraception and other risk factors. | in a case-control study of matched pairs, the risk of acute pelvic inflammatory disease (pid) was 4.4 times higher in intrauterine contraceptive device (iud) users than in nonusers (p less than 0.001). of approximately 500,000 cases of acute pid occurring annually in the united states, an estimated 110,000 are attributable to iud's, costing over forty-four million dollars per year. pid was attributable to the iud in 77 per cent of iud users. no particular type of iud was implicated. the relative ... | 1977 | 407795 |
| in vitro activity of p-hydroxybenzyl penicillin (penicillin x) and five other penicillins against neisseria gonorrhoeae: comparisons of strains from patients with uncomplicated infections and from women with pelvic inflammatory disease. | minimum inhibitory concentrations (mics) of six penicillins against 95 strains of neisseria gonorrhoeae from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. against all 117 strains, the order of activity observed was: bl-p1654 > penicillin x > penicillin g > ampicillin > amoxicillin = carbenicillin. mics against strains isolated from women with gonococcal pe ... | 1977 | 407840 |
| penicillinase-producing neisseria gonorrhoeae: detection by starch paper technique. | | 1977 | 407968 |
| inhibition of attachment of neisseria gonorrhoeae to tissue cells by goat milk antigonococcal immunoglobulin g. | an immunoglobulin g (igg)-containing fraction was isolated from milk, obtained from a goat before and after instillation of the mammary gland with neisseria gonorrhoeae colony type 1 (t1). the presence of igg and the absence of immunoglobulins-a and -m in this fraction was confirmed by immunodiffusion in gel and immunoelectrophoresis. postinstillation igg inhibited the attachment of the homologous strain of n. gonorrhoeae (t1) to tissue cells. the percentage of rhesus monkey kidney cells with go ... | 1977 | 407995 |
| enhanced stability of meningococcal polysaccharide vaccines by using lactose as a menstruum for lyophilization. | a comparison is made between lactose and mannitol as additives for the lyophilization of meningococcal polysaccharide vaccines. from the stability data obtained on storage at high temperatures, it is concluded that vaccines containing lactose as a menstruum for lyophilization are much more stable than vaccines prepared with the currently used additive, mannitol. the enhanced stability of these vaccines makes it possible to store also group a vaccines at 5 degrees c instead of at -20 degrees c, a ... | 1977 | 408022 |
| an appraisal of vitamin c in adjunct therapy of bacterial and "viral" meningitis. | | 1977 | 408071 |
| meningococcal polysaccharide vaccines: recommendations of the public health service advisory committee on immunization practices. | | 1977 | 408072 |
| standardization and control of meningococcal vaccines, group a and group c polysaccharides. | | 1977 | 408354 |
| immunologic classification of neisseria gonorrhoeae with micro-immunofluorescence. | a reproducible immunologic classification of neisseria gonorrhoeae strains has been achieved by the micro-immunofluorescence (micro-if)3 method by using formalinized whole organisms as test antigens and mouse antisera prepared by i.v. immunization with the whole organisms as antibody. immunologic differences among neisseria species were also distinct in this test system. immunologic differences among gonococcal strains were not influenced by gonococcal colony type. classification of gonococci wa ... | 1977 | 408415 |
| immunoepidemiology of meningococcal disease in military recruits. i. a model for serogroup independency of epidemic potential as determined by serotyping. | one hundred twenty strains of neisseria meningitidis were serotyped with use of cross-absorbed rabbit antisera in a bactericidal test. fifty-eight epidemic strains of serogroup b, c, and y that occurred simultaneously among military recruits at two basic training centers during a period of epidemic meningococcal disease were compared with 62 strains of serogroups a, b, c, and y isolated worldwide. antisera to the six original antigenic factors of the gold serotyping schema were adequate for typi ... | 1977 | 408422 |
| ultrastructural study of cervical gonorrhea. | an ultrastructural examination of the squamocolumnar junction of the cervix of patients infected with neisseria gonorrhoeae is described. gonococci were found to become firmly attached to stratified squamous epithelium, a process that appeared to be initiated by activity of the cytoplasmic membrane of superficial squames. by contrast, gonococci were not found attached to, or even closely associated with, mucus-secreting columnar epithelium. gonococcal growth, as evidenced by numbers of organisms ... | 1977 | 408425 |
| protection against infection with neisseria gonorrhoeae by immunization with outer membrane protein complex and purified pili. | some of the antigens that are capable of producing strain-related immunity to gonococcal infection in the guinea pig are located on the outer membrane of neisseria gonorrhoeae. this finding has been demonstrated by immunization of guinea pigs with isolated outer membranes from two different strains of n. gonorrhoeae prior to challenged. isolated principal outer membrane protein complex proved a better protective immunogen than purified pili from the same strain of n. gonorrhoeae. principal outer ... | 1977 | 408428 |
| surface components affecting interactions between neisserai gonorrhoeae and eucaryotic cells. | interactions of neisseria gonorrhoeae with nonleukocytic eucaryotic cells including tissue culture cells (either primary or continuous lines), human sperm, and buccal mucosal cells appear to be influenced primarily by the presence or absence of pili on the bacteria. in this context, piliation enhances attachment to or association of microorganisms with the eucaryotic cells. pili, on the other hand, appear to reduce interaction of n. gonorrhoeae with mouse peritoneal macrophages. other groups hav ... | 1977 | 408429 |
| immune response of human infants of polysaccharide vaccines of group a and c neisseria meningitidis. | | 1977 | 408431 |
| polysaccharide vaccines of group a neisseria meningtitidis and haemophilus influenzae type b: a field trial in finland. | | 1977 | 408432 |
| interim report of a controlled field trial of immunization with capsular polysaccharides of haemophilus influenzae type b and group c neisseria meningitidis in mecklenburg county, north carolina (march 1974-march 1976). | approximately 16,000 children, from two months to five years of age, were vaccinated with the capsular polysaccharide of either haemophilus influenzae type b or group c neisseria meningitidis. immunizations were carried out in a double-masked, randomized manner; the doses of immunogens used were 10 microgram of h. influenzae type b polysaccharide and 25 micron g of the group cn. meningitidis polysaccharide. immunogenicity of the two vaccines was measured in single, random specimens of blood take ... | 1977 | 408433 |
| sialic acid-containing polysaccharides of neisseria meningitidis and escherichia coli strain bos-12: structure and immunology. | a polysaccharide antigenically related to that of group c neisseria meningitidis was isolated from escherichia coli strain bos-12 (o48: k91:nm). like the polysaccharides of groups b and cn. meningitidis, the bos-12 antigen was shown to be a pure polymer of sialic acid. the 13c-nuclear magnetic resonance studies of the groups b and c polysaccharides indicated that the former consists of units of sialic acid joined in alpha-2 leads to 8 linkages, whereas the latter contains sialic acid residues li ... | 1977 | 408434 |
| strucutres of the capsular polysaccharides of neisseria meningitidis as determined by 13c-nuclear magnetic resonance spectroscopy. | the application of 13c-nuclear magnetic resonance spectroscopy to the structural determination of the capsular polysaccharide antigens of neisseria meningitidis is described. complete assignments of the spectra of the polysaccharides of serogroups a, b, c, w-135, x and y were made and were based mainly on previous assignments made for the monomer units of the respective polysaccharides. this technique provides information on all structural aspects of the polysaccharides including composition, mo ... | 1977 | 408435 |
| role of protein serotype antigens in protection against disease due to neisseria meningitidis. | evidence is provided for the protective effects of antibody to noncapsular antigens in immunity to meningococcal disease. serotype 2 strains were associated with 50% of disease due to group b neisseria meningitidis in europe. the amount of serotype antibody in normal individuals is related to age, and adult levels are reached by about 10 years of age. children under two years of age who have recovered from disease due to groups b and cn. meningitidis of serotype 2 make antibody to serotype 2; th ... | 1977 | 408436 |
| studies on the mechanism of pathogenicity of neisseria gonorrhoeae. | | 1977 | 408492 |
| reversion of kellogg's colonial types of neisseria gonorrhoeae in liquid medium. | colonial type variation of gonococci is well known, but change from type 4 to type 4 to type 1 is rare except in vivo. by observing quantitatively subcultures from a new liquid medium it was possible to follow the day-to-day changes in the ratio of colonial types present. the results obtained showed that type 1 colonies could be derived from type 5 inocula even in unsupplemented media. in unsupplemented liquid medium, type 4 inocula did not revert to other types and indeed colonial type 4 appear ... | 1977 | 408494 |
| comparison of erythromycin base and estolate in gonococcal urethritis. | a randomized double-blind trial of 152 men with gonococcal urethritis compared the therapeutic efficacy of erythromycin estolate and erythromycin base. twenty-one of 86 (24%) men treated with the estolate and 15 of 66 (23%) treated with the base had recurrent or persistent gonococcal infection when seen after a 9-g course of erythromycin. the serum erythromycin activity among estolate-treated patients (3.57 +/- 0.84 microgram/ml) was nearly twice that for base-treated patients (1.76 +/- 0.80 mic ... | 1977 | 408522 |
| [epidemiological study of meningococcus b in an open environment and prevention of cerebrospinal meninitis (apropos of 450 rhino-pharyngeal specimens and 95 anti-meningococcal sera)]. | | 1977 | 408574 |
| clinical efficacy of meningococcus group a capsular polysaccharide vaccine in children three months to five years of age. | we performed field trials in the course of an epidemic in finland to learn whether group a memingococcal capsular polysaccharide vaccine protects infants and young children from meningitis. the first trial involved 130,178 children between the ages of three months and five years; 49,295 children received the vaccine, 48,977 received a control haemophilus influenzae type b polysaccharide vaccine, and 31.906 remained unvaccinated. no cases of meningitis or sepsis caused by group a meningococci wer ... | 1977 | 408682 |
| further conquest of the meningococcus. | | 1977 | 408684 |
| gonococcal tonsillitis. report of a case. | oral gonorrhea is not a commonly reported entity. one case of primary gonococcal tonsillitis in a 20-year-old caucasian man is reported. the clinical and laboratory findings, differential diagnosis, and treatment of gonococcal infections are briefly reviewed. | 1977 | 408777 |
| clinical and serological evaluation of purified polysaccharide vaccines prepared from neisseria meningitidis group y. | | 1977 | 408813 |
| [mycoplasma organisms in non-gonorrheal disorders of the genitourinary organs in patients treated at the provincial dermatovenereal dispensary in cracow]. | | 1977 | 408879 |
| [slide coagglutination test in the diagnosis of n. gonorrhoeae on solid media]. | | 1977 | 408880 |
| [selected clinical, epidemiological and therapeutic aspects of non-gonorrheal urethritis in males]. | | 1977 | 408881 |
| immunological investigations of meningococcal disease. iii. brevity of group c acquisition prior to disease occurrence. | a surveillance program to determine group c meningococcal acquisition in military personnel during an epidemic was made. data from fortnightly nasopharyngeal cultures show that individuals who were admitted with meningococcal disease acquired the organism within a week of disease onset. there were 24 company/platoons in which a single case occurred. six company/platoons had 2 cases each. while other conditions which could act as predisposing factors were not ruled out, the data here favor acute ... | 1977 | 408918 |
| [possibility of formation of gonococcal l-forms in patients with chronic and torpid gonorrhea]. | | 1977 | 408994 |
| [characteristics of neisseria gonorrhoeae colonies studied with the aid of the kellogg's method]. | | 1977 | 409004 |
| meningococcal bacteremia: clinical and serologic studies of infants with mild illness. | we report three mildly ill infants who had meningococcal bacteremia and in whom meningitis or fulminant septicemia never developed. the infants were observed during a three-month period. two of these infants had pneumonia, as evidenced by infiltrates on chest roentgenogram. the serogroups of the organisms isolated were b, y, and 135. in none of the infants could specific bactericidal antibody be demonstrated in acute or convalescent serum. | 1977 | 409280 |
| differences between sexes in the nasopharyngeal carriage of neisseria meningitidis. | nasopharyngeal carriage of neisseria meningitidis was investigated among male and female students sharing similar occupational and living environments at the u.s. naval hospital corps school, great lakes, illinois, in 1972-1973. when students beginning the study without meningococcal carriage were evaluated, meningococcal acquisition, weekly carrier prevalence, number of different serogroups carried, proportion of serogroup y carriers, and average duration of group y carriage were approximately ... | 1977 | 409282 |
| futility of routine culture of hysterectomy specimens for gonorrhea. | | 1977 | 409293 |
| auxotypes and penicillin susceptibilities of neisseria gonorrhoeae isolated from patients with gonorrhea involving two or more sites. | a system of auxotyping described in 1973 is based on the differing nutritional requirement patterns of neisseria gonorrhoeae strains. our ongoing evaluation of the reliability of auxotyping has involved a study of the constancy of characteristics of gonococci isolated at one time from two or more sites of a given subject. the auxotypes and minimal inhibitory concentration (mic) of penicillin g were determined for 181 isolates obtained from 84 patients with uncomplicated gonorrhea, for 16 isolate ... | 1977 | 409341 |
| transfer of plasmid-borne beta-lactamase in neisseria gonorrhoeae. | neisseria gonorrhoeae strain gc82 contains a plasmid specifying a beta-lactamase (beta-lam(+)). mixed incubation of strain gc82 with a penicillin-susceptible (beta-lam(-)), streptomycin-resistant mutant of strain gc9 results in the expression of beta-lactamase activity and streptomycin resistance in the transcipients. the frequency of transfer of the plasmid-specified resistance to penicillin seems to be proportional to the initial input ratio of the mating mixture of donor to recipient and to c ... | 1977 | 409343 |
| in vitro activity of rosamicin against neisseria and haemophilus, including penicillinase-producing strains. | rosamicin was significantly more active against haemophilus and neisseria than are many antibiotics currently used to treat or prevent infection caused by these organisms. this enhanced activity was also observed against penicillinase-producing strains. | 1977 | 409345 |
| mitogenic activity of neisseria gonorrhoeae surface antigens in mouse splenic lymphocyte culture. | the mitogenic effects of neisseria gonorrhoeae endotoxin, fractionated envelope componenents, and intact cells were examined on unsensitized mouse splenic lymphocytes in vitro. the stimulatory effect of these substances was measured by increased [3h]thymidine incorporation in spleen cell cultures. intact cells, purified lipopolysaccharide (lps), and cell envelope preparations were highly stimulatory and the stimulation index was dose dependent. fractionated components of the envelope demonstrate ... | 1977 | 409466 |
| virulence and immunogenicity of types 1 and 3 neisseria gonorrhoeae in guinea pig subcutaneous chambers. | the relative virulence and immunogenicity of type 1 (t1) and type 3 (t3) cells of neisseria gonorrhoeae were determined by tests with two different kinds of subcutaneous chambers in guinea pigs. in tests with a tissue nonencapsulated (ne) chamber, t1 gonococci were found to be greater than 1000 times more virulent as well as about 1000 times more immunogenic than t3 cells of the same gonococcal strain. however, t1 and t3 cells were found to be equally virulent for a tissue encapsulated (te) cham ... | 1977 | 409469 |
| primary meningococcal peritonitis. | | 1977 | 409473 |
| oropharyngeal gonorrhea: disseminated gonococcal disease. | | 1977 | 409474 |
| [rapid identification of n. gonorrhoeae by coagglutination on slides (author's transl)]. | | 1977 | 409508 |