| molecular characterization of three novel murine noroviruses. | murine noroviruses (mnv) comprise a group of newly recognized pathogens infecting laboratory mice. the first reported murine norovirus, murine norovirus 1 (mnv-1), produces a transient infection with a short duration of fecal shedding after infection of immunocompetent laboratory mice. our laboratory subsequently isolated three novel murine noroviruses, murine norovirus 2 (mnv-2), murine norovirus 3 (mnv-3), and murine norovirus 4 (mnv-4), that have markedly different pathogenicity from mnv-1 by ... | 2007 | 17171545 |
| infection with murine norovirus 4 does not alter helicobacter-induced inflammatory bowel disease in il10(-/-) mice. | infection of laboratory mice with murine noroviruses (mnv) is widely prevalent. mnv alters various mouse models of disease, including the helicobacter bilis-induced mouse model of inflammatory bowel disease (ibd) in mdr1a(--) mice. to further characterize the effect of mnv on ibd, we used mice deficient in the immunoregulatory cytokine il10 (il10(-/-) mice). in vitro infection of il10(-/-) bone marrow-derived macrophages (bmdm) with mnv4 cocultured with h. bilis antigens increased the gene expre ... | 2014 | 25296012 |
| soiled-bedding sentinel detection of murine norovirus 4. | according to serologic surveys, murine norovirus (mnv) is the most prevalent viral pathogen infecting mice used in biomedical research. however, the use of sentinel mice to detect mnv-infected mouse populations has not been evaluated thoroughly. to this end, an experimental method of soiled bedding transfer was created to mimic a quarterly sentinel monitoring program. soiled bedding (15 or 30 cm3) from icr mice experimentally infected with mnv4 was transferred weekly to cages of pair-housed 4-wk ... | 2008 | 18459710 |