| variation between strains of hamsters in the lethality of pichinde virus infections. | infection by pichinde virus, a member of the arenavirus group, was studied in golden syrian hamsters (mesocricetus auratus) with regard to possible mechanisms of resistance to virus infection in adult hamsters. two hamster strains were found to differ in their susceptibility to lethal pichinde virus infection. lvg/lak randomly bred hamsters were found to be 100% susceptible to low doses of pichinde virus during the first 6 days of life, but after 8 days of life, mortality was uncommon. peak viru ... | 1977 | 193786 |
| susceptibility to fatal pichinde virus infection in the syrian hamster. | the data presented in this paper suggest that the susceptible mha hamster strain possesses a spleen target cell for pichinde virus replication which is minimally expressed in the resistant strain. this target cell co-purifies with cells mediating nk activity, raising the possibility that the nk cell itself may be the additional target cell for pichinde virus replication in the susceptible hamster strain. we hypothesize that early virus replication in the spleens of ip-inoculated hamsters leads t ... | 1981 | 6261541 |
| the nucleoprotein of pichinde virus expressed by a vaccinia-pichinde virus recombinant partially protects hamsters from lethal virus challenge. | syrian hamsters, strain mha/lak, are susceptible to intraperitoneal infection with pichinde virus and die from an overwhelming viremia. we have studied the ability of a vaccinia-pichinde recombinant virus expressing amino acids 51-561 of the viral nucleoprotein (vvnp51-561) to protect from lethal pichinde virus infection. priming with vvnp51-561 significantly delayed mortality and increased final survival outcome after challenge with 2 x 10(3) pfu of pichinde virus. this protection was not compl ... | 1994 | 7826212 |
| characterization of the host response to pichinde virus infection in the syrian golden hamster by species-specific kinome analysis. | the syrian golden hamster has been increasingly used to study viral hemorrhagic fever (vhf) pathogenesis and countermeasure efficacy. as vhfs are a global health concern, well-characterized animal models are essential for both the development of therapeutics and vaccines as well as for increasing our understanding of the molecular events that underlie viral pathogenesis. however, the paucity of reagents or platforms that are available for studying hamsters at a molecular level limits the ability ... | 2015 | 25573744 |
| differences in lymphocyte responsiveness to lymphokines in two inbred strains of syrian hamster. | two inbred strains of syrian hamster have been shown to display differences in splenic nk cell activity both endogenously and after infection with pichinde virus. on further investigation of these differences, it was found that the spleens and thymuses of the high nk strain, mha, displayed greater cellularity than those of the low nk strain, lsh. additionally, thymocytes from mha hamsters were found to proliferate to a greater extent than those of lsh hamsters in response to con a-induced condit ... | 1984 | 6609982 |
| role of natural killer cells in pichinde virus infection of syrian hamsters. | pichinde virus produced a fatal infection in adult mha hamsters but not lsh hamsters after intraperitoneal inoculation. after footpad inoculation, an 8-day swelling response was observed in lsh but not mha hamsters; however, both strains survived infection by this route. examination of the kinetics of viral replication in the two hamster strains inoculated by the two routes revealed a correlation between infectious centers and natural killer activity in cells obtained from spleens and popliteal ... | 1981 | 6262252 |
| pichinde virus-specific cell-associated suppression of primary footpad swelling in an inbred strain of syrian hamsters. | pichinde virus causes a lethal disease after i.p. inoculation of adult mha hamsters; other strains of syrian hamsters are resistant to this lethal infection. during studies of cell-mediated immune responses to pichinde virus, it was noted that mha hamsters survived infection when the virus was given in the footpad. however, unlike the resistant lsh and lvg strains of hamsters, the mha hamsters did not manifest a footpad swelling response. failure of the mha hamster to respond to a footpad inocul ... | 1983 | 6184408 |
| differences between syrian hamster strains in natural killer cell activity induced by infection with pichinde virus. | | 1979 | 501084 |