| seroprevalence of human papillomavirus-16, -18, -31, and -45 in a population-based cohort of 10000 women in costa rica. | human papillomavirus (hpv) seroprevalence and determinants of seropositivity were assessed in a 10049-woman population-based cohort in guanacaste, costa rica. serologic responses based on vlp-based elisa were obtained from the plasma collected at study enrollment in 1993/1994 for hpv-16 (n=9949), hpv-18 (n=9928), hpv-31 (n=9932), and hpv-45 (n=3019). seropositivity was defined as five standard deviations above the mean optical density obtained for studied virgins (n=573). hpv-16, -18, -31, and - ... | 2003 | 14520455 |
| human papillomavirus types by age in cervical cancer precursors: predominance of human papillomavirus 16 in young women. | in a population-based study conducted in guanacaste, costa rica, we investigated the human papillomavirus (hpv) types detected in 233 cases of cervical intraepithelial neoplasia (cin) 2/3 and cancer by age. cin2+ and cin3+ in young women were significantly more likely to be associated with hpv 16 than the same lesions in older women (80% of cin3+ were associated with hpv 16 among women ages 18-26 years compared with only 32% among women older than 55 years; ptrend=0.018). there were no differenc ... | 2009 | 19273486 |
| rationale and design of a community-based double-blind randomized clinical trial of an hpv 16 and 18 vaccine in guanacaste, costa rica. | we report the rationale, design, methods and details of participation of a community-based, double-blind, randomized clinical trial of an hpv 16 and 18 vaccine conducted in two provinces of costa rica to investigate the efficacy and population impact of the vaccine in the prevention of cervical cancer precursors. more than 24,000 women between 18 and 25 years of age were invited to participate and pre-screened for eligibility, with recruitment of 7466 women (30% of those pre-screened, 59% of tho ... | 2008 | 18640170 |
| high load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only hpv16 load predicts the development of incident disease. | cervicovaginal human papillomavirus (hpv) viral load has been purported as a potential marker for the detection of high-grade cervical intraepithelial neoplasia or cancer (>/=cin2). to examine disease association with type-specific viral load for the full-range of anogenital hpv infections, we conducted cross-sectional and prospective analyses of approximately 2,000 hpv-infected women from a 10,000-woman population-based study in guanacaste, costa rica with 7 years of follow-up. cervical specime ... | 2007 | 17722112 |
| comparison of the spf10-lipa system to the hybrid capture 2 assay for detection of carcinogenic human papillomavirus genotypes among 5,683 young women in guanacaste, costa rica. | the objective of this analysis was to compare the performance characteristics of two human papillomavirus (hpv) dna detections assays, the hybrid capture 2 assay (hc2) and the spf(10) assay, for the detection of carcinogenic hpv. data are from the enrollment visits of women who participated in the randomized, double-blind, placebo-controlled phase iii hpv16/18 vaccine trial in guanacaste, costa rica. we compared the results of hc2 and spf(10) testing of cervical specimens. since the line probe a ... | 2007 | 17344361 |
| determinants of human papillomavirus 16 serological conversion and persistence in a population-based cohort of 10 000 women in costa rica. | determinants of human papillomavirus (hpv)-16 serological conversion and persistence were assessed in a population-based cohort of 10 049 women in guanacaste, costa rica. serologic responses to hpv-16 were measured in 7986 women by vlp-based enzyme-linked immunosorbent assay at both study enrollment (1993/94) and at 5-7 years of follow-up. seropositive women were defined as >/=5 standard deviations above the mean optical density obtained for studied virgins at enrollment (n=573). seroconnversion ... | 2004 | 15292929 |