| status of carbohydrate, protein and lipid profile in the mosquito larvae treated with certain phytoextracts. | to investigate the impact of the most potent petroleum ether extract of artemisia annua (a. annua) and azadirachta indica (az. indica) on total carbohydrate, lipid and protein level of anopheles stephensi and culex quinquefasciatus larvae. | 2011 | 21771474 |
| gc-based analysis of insecticidal constituents of the flowers of azadirachta indica a. juss. | the present article describes the analysis of an n-hexane soluble fraction of fresh flowers of azadirachta indica a. juss (neem), possessing larvicidal activity against anopheles stephensi liston, a vector of malarial parasite. forty-one compounds were identified in non-polar to less-polar fraction as well as in essential oil. these identifications were basically made through gc-eims. thus 5 sesquiterpenes, 3 aromatics, 17 fatty acids, 5 fatty acid esters, three steroids and 8 hydrocarbons were ... | 2009 | 19235028 |
| effects of a neem extract on blood feeding, oviposition and oocyte ultrastructure in anopheles stephensi liston (diptera: culicidae). | secondary metabolites of the neem tree (azadirachta indica a. juss., meliaceae) exhibit a wide range of biological activities in insects. however, few studies have addressed the effects of neem extracts or compounds in arthropods of medical importance. in this study, a laboratory strain of anopheles stephensi was used to assess the effects of a commercial formulation (neem azal) (na)), containing azadirachtin a at 34%, on blood feeding, oviposition and oocyte ultrastructure. oral administration ... | 2006 | 17097701 |
| effective method for extraction of larvicidal component from leaves of azadirachta indica and artemisia annua linn. | leaves of artemisia annua linn. and azadirachta indica were extracted in petroleum ether and hexane respectively by different methods of extraction i.e. cold extraction, reflux extraction and soxhlet extraction. the crude extract obtained was tested against third instar larvae of anopheles stephensi. on comparison of larval mortality of crude extract obtained by these three methods, both soxhlet and reflux extraction method showed 100% mortality at 200 ppm after 48 hr in case of a. annua. howeve ... | 2006 | 16850885 |
| effects of neem limonoids on the malaria vector anopheles stephensi liston (diptera: culicidae). | the effects of the neem (azadirachta indica a. juss) limonoids azadirachtin, salannin, deacetylgedunin, gedunin, 17-hydroxyazadiradione and deacetylnimbin on anopheles stephensi liston (diptera: culicidae) were investigated. in exploring advantages of pure neem limonoids, we studied the larvicidal, pupicidal, adulticidal and antiovipositional activity of neem limonoids. azadirachtin, salannin and deacetylgedunin showed high bioactivity at all doses, while the rest of the neem limonoids were less ... | 2005 | 16112073 |
| analysis of insecticidal azadirachta indica a. juss. fractions. | as a result of chemical investigation on the ethanolic extract of fresh fruit coatings of azadirachta indica a. juss. (neem), twenty-seven compounds were identified in non-polar to less polar fractions which showed pesticidal activity determined by who method against anopheles stephensi liston. these identifications were basically made through gc-eims and were further supported by other spectroscopic techniques, including 13c nmr, uv and ftir as well as retention indices. thus sixteen n-alkanes, ... | 2009 | 15018062 |
| tetracyclic triterpenoids from the leaves of azadirachta indica and their insecticidal activities. | a new tetranortriterpenoid, meliatetraolenone [24,25,26,27-tetranor-apotirucalla-(apoeupha)-6alpha-o-methyl, 7alpha-senecioyl(7-deacetyl)-11alpha,12alpha,21,23-tetrahydroxy-21,23-epoxy-2,14,20(22)-trien-1,16-dione] (1) was isolated from the methanolic extract of fresh leaves of azadirachta indica along with the known compound odoratone (3) which was hitherto unreported from this source. their structures have been elucidated by spectral studies including 2d nmr. the insecticidal activities of 1 a ... | 2003 | 12672995 |
| first results of the application of a new neemazal powder formulation in hydroponics against different pest insects. | neemazal pc (0.5% azadirachtin) is a new standardised powder formulation from the seed kernels of the tropical neem tree (azadirachta indica a. juss) with an inert carrier. first experiments with beans--as a model-system for hydroponics--show that active ingredient is taken up by the plants through the roots and is transported efficiently with the plant sap to the leaves. after application of neemazal pc solution (0.01-1%) to the roots sucking (aphis fabae hom., aphididae) and free feeding (heli ... | 2002 | 12696431 |
| repellency of the oily extract of neem seeds (azadirachta indica) against varroa destructor (acari: varroidae). | a crude oil extract of neem seed (azadirachta indica, sapindales: meliaceae) was evaluated for repellency on varroa destructor anderson and trueman. burgerjon's tower was used to spray worker bee pupae with 0.0, 0.3, 0.7, 1.3, 2.6, 5.3, 10.6 and 21.1% neem extract concentrations. sprayed pupae were attached to observation arenas and incubated at 32 ± 2°c and 70 ± 10% rh. the ability of v. destructor to locate and feed on treated and untreated pupae was monitored from 30 min to 72 h after spray. ... | 2012 | 22270115 |
| efficacy and insecticidal properties of some essential oils against caryedon serratus (oliver)-a storage pest of groundnut. | during storage groundnut is attacked by number of stored grain pest and management of these insect pests particularly bruchid beetle, caryedon serratus (oliver) is of prime importance as they directly damage the pod and kernels. hence, some essential oils were tested for their insecticidal and fungicidal properties. highest total bruchid mortality was recorded with the application of neem oil and pongamia oil at 10% (v/w) concentration and lowest in eucalyptus oil at 5% (v/w). number of eggs lai ... | 2014 | 26396354 |
| a comparative study on the decomposition of edible and non-edible oil cakes in the gangetic alluvial soil of west bengal. | an experiment has been conducted under laboratory conditions to investigate the effect of decomposition of two edible oil cakes, viz. mustard cake (brassica juncea l) and groundnut cake (arachis hypogaea l), and two non-edible oil cakes, viz. mahua cake (madhuca indica gmel) and neem cake (azadirachta indica juss), at the rate of 5.0 t ha(-1) on the changes of microbial growth and activities in relation to transformations and availability of some plant nutrients in the gangetic alluvial (typic h ... | 2014 | 24733437 |
| an ethnobotanical survey of medicinal plants used in terai forest of western nepal. | nepal himalayas have been known as a rich source for valuable medicinal plants since vedic periods. present work is the documentation of indigenous knowledge on plant utilization as natural remedy by the inhabitants of terai forest in western nepal. | 2012 | 22591592 |
| a comparative study of vamana and virechana karma in the management of sthula pramehi w.s.r. to type-2 diabetes. | in the present study, vamana and virechana along with palliative treatment was given to patients of sthula prameha (diabetes mellitus or dm). an attempt was made to compare and evaluate the role of shodhana therapy (vamana and virechana). total 47 patients of sthula pramehi were registered in this study, out of which 38 completed the treatment. the patients were divided into two groups, viz. vamana with shamana (group a) and virechana with shamana (group b). eighteen patients completed the treat ... | 2011 | 22661850 |
| medicinal plants useful for malaria therapy in okeigbo, ondo state, southwest nigeria. | there is increasing resistance of malaria parasites to chloroquine, the cheapest and commonly used drug for malaria in nigeria. artemisin, a product from medicinal plant indigenous to china, based on active principle of artemisia annua, has been introduced into the nigerian market. however not much has been done to project antimalaria properties of indigenous medicinal plants. this study thus, has the main objective of presenting medicinal plants used for malaria therapy in okeigbo, ondo state, ... | 2006 | 20162091 |
| medicinal and aromatic plant materials as nitrification inhibitors for augmenting yield and nitrogen uptake of japanese mint (mentha arvensis l. var. piperascens). | pot experiments were conducted to evaluate the relative performance of medicinal and aromatic plant materials and dicyandiamide (dcd) as nitrification inhibitors to regulate transformation of n from urea. their effect on the efficiencies of use of n by japanese mint (mentha arvensis cv. hy 77) was tested. urea was coated with these materials viz., mentha spicata, artemisia annua or dcd at the rate of 5% (w/w) of fertilizer urea using an appropriate coating technique. nimin (tetranortriterpenoids ... | 2003 | 12688470 |
| emulsion of chloramphenicol: an overwhelming approach for ocular delivery. | ophthalmic formulations of chloramphenicol have poor bioavailability of chloramphenicol in the ocular cavity. | 2017 | 28384103 |
| nimbolide induces apoptosis in human nasopharyngeal cancer cells. | nasopharyngeal carcinoma (npc), a tumor arising from epithelial cells that cover the surface and line the nasopharynx, is a rare malignancy worldwide but is prevalent in certain geographical areas, such as southern asia (taiwan, hong kong, singapore, malaysia, and southern china) and north africa. despite advances in diagnostic techniques and improvements in treatment modalities, the prognosis of npc remains poor. therefore, an effective chemotherapy regimen that enhances tumor sensitivity to ch ... | 2017 | 28383207 |
| the effects of neem oil (azadirachta indica a. juss) enriched with different concentrations of azadirachtin on the integument of semi-engorged rhipicephalus sanguineus sensu lato (acari: ixodidae) females. | several studies searching for methods to control rhipicephalus sanguineus s.l., (dog tick) infestations have been developed aiming to minimize the damages caused by these ectoparasites to the hosts and the environment, which is harmed by the indiscriminate use of toxic acaricide products. in this scenario, neem oil has been used as a natural alternative against ticks, once this chemical has repellent properties and interferes in the growth regulation of these ectoparasites, inhibiting ecdysis. t ... | 2017 | 28370810 |
| transcriptomics and proteomic studies reveal acaricidal mechanism of octadecanoic acid-3, 4 - tetrahydrofuran diester against sarcoptes scabiei var. cuniculi. | in our previous study, a new compound, octadecanoic acid-3, 4-tetrahydrofuran diester, possessing potent acaricidal activity was obtained from neem oil. this study performed rna-seq transcriptomics and itraq proteomics to uncover the acaricidal mechanism of the compound against sarcoptes scabiei var. cuniculi. the results of transcriptomics indicated that after treatment with octadecanoic acid-3, 4-tetrahydrofuran diester, genes related to "energy metabolism" were significantly up-/down-regulate ... | 2017 | 28361965 |
| in vitro antioxidant and antidiabetic activities of zinc oxide nanoparticles synthesized using different plant extracts. | phytofabricated green synthesis of zinc oxide (zno) nanoparticles using different plant extracts of azadirachta indica, hibiscus rosa-sinensis, murraya koenigii, moringa oleifera, and tamarindus indica for biological applications has been reported. zno nanoparticles were also synthesized by chemical method to compare the efficiency of the green synthesized nanoparticles. ft-ir spectra confirmed the functional groups involved in the green synthesis of zno nanoparticles and the powder xrd patterns ... | 2017 | 28361361 |
| ultrastructural changes in raillietina (platyhelminthes: cestoda), exposed to sulfonoquinovosyldiacylglyceride (sqdg), isolated from neem (azadirachta indica). | neem (azadirachta indica), has been known to be a curative for various ailments and diseases in the traditional indian medicinal system from times immemorial. a glycolipid sulfonoquinovosyldiacylglyceride (sqdg) isolated from the leaves of neem has been found to be a proactive antibacterial and antiviral agent in previous studies. the current communication pertains to the anthelmintic activity of sqdg in vitro against a model cestode raillietina spp. the results of efficacy tests showed a paraly ... | 2017 | 28347172 |
| enhanced hplc-dad method for fast determination of quercetin-3-o-β-d-glucoside in extracts and polyherbal formulations containing azadirachta indica-optimization and validation. | azadirachta indica has been used for its medicinal properties since time immemorial. herbal medicines which are prepared using this medicinal tree are utilized to treat various diseases and disorders. no reports are available for marker-based standardization of these herbal medicines prepared from leaves of a. indica. also existing hplc methods for determination quercetin-3-o-β-d-glucoside are time consuming. there is an obvious need for development of new hplc method for quantification of querc ... | 2017 | 28334842 |
| topical application of neem leaves prevents wrinkles formation in uvb-exposed hairless mice. | | 2017 | 28319870 |
| in vitro evaluation of antifilarial effect of azadirachta indica leaves extract in different solvents on the microfilariae of setaria cervi. | polar solvent extracts of azadirachta indica leaves were investigated to evaluate in vitro anthelmintic activity on the microfilariae of setaria cervi. four extracts of a. indica leaves were prepared with different solvents in increasing order of polarity (diethyl ether < chloroform < ethanol < methanol). stock solution of the extract of a. indica leaves was prepared in ringer's solution at the concentrations of 50, 100 and 200 μg/ml and used against microfilariae in three replicates. ringer's s ... | 2017 | 28316381 |
| lethal and sublethal effects of pesticides in the management of polyphagotarsonemus latus (banks) (acari: tarsonemidae) on capsicum annuum l. | the evaluation of lethal and sublethal effects are of great importance for a complete assessment of the total impact of chemical compounds upon pest populations and the development of management strategies. at this study, the lethal and sublethal effects of different synthetic and botanical products were evaluated upon the broad mite, polyphagotarsonemus latus (banks), a major pest of capsicum annuum l and other crops. | 2017 | 28296187 |
| evaluation of antioxidant and anticancer activity of copper oxide nanoparticles synthesized using medicinally important plant extracts. | copper oxide (cuo) nanoparticles were synthesized by green chemistry approach using different plant extracts obtained from the leaves of azadirachta indica, hibiscus rosa-sinensis, murraya koenigii, moringa oleifera and tamarindus indica. in order to compare their efficiency, the same copper oxide nanoparticles was also synthesized by chemical method. phytochemical screening of the leaf extracts showed the presence of carbohydrates, flavonoids, glycosides, phenolic compounds, saponins, tannins, ... | 2017 | 28292015 |
| a new azadirachta from the crude extracts of neem (azadirachta indica a. juss) seeds. | one new compound, 2h, 3h-cyclopent[b] furo [2',3':4,5] naphtho [2,4-d] heptlactone-[3,7] furan-6aceticacid, 3-(acetyloxy)-8-(3-furyl)-2a, 4a, 4b, 4c,5,5a, 6, 6a, 8, 9,9a, 10a,10b-13 hydrogen-2a,5a,6a,5-tetramethyl-3-[[(2e)-2-methyl-1-oxo-2-butenyl]oxy]-methyl ester, named azadirachta r (1), along with 10 known ones, azadirachta a, az-b, az-d, az-h, az-i, nimbin, deacetylnimbin, salannin, deacetylsalannin and azadiradione were isolated from the crude extracts of neem (azadirachta indica a. juss) ... | 2017 | 28278641 |
| in vitro evaluation of acaricidal activity of novel green silver nanoparticles against deltamethrin resistance rhipicephalus (boophilus) microplus. | an investigation was undertaken to study, for the first time, in vitro acaricidal activity of green silver nanoparticles on deltamethrin resistance rhipicephalus (boophilus) microplus. the compounds tested were neem coated silver nanoparticles (n-ag nps), deltamethrin neem coated silver nanoparticles (dn-ag nps), 2, 3 dehydrosalannol (2,3 dhs), 2, 3 dhs coated silver nanoparticles (2, 3-dhs-ag nps), quercetin dihydrate (qdh) and qdh coated silver nanoparticles (qdh-ag nps). also included in this ... | 2017 | 28246003 |
| synthesis of chitosan incorporated neem seed extract (azadirachta indica) for medical textiles. | in present study, eco-friendly biosynthesis of chitosan-neem seed (cs-ns) composite was prepared by co-precipitation method using aqueous neem seed extract. cotton fabrics were treated with two different crosslinking agents (glutaraldehyde and citric acid) then the synthesized composite coated on cotton fabric by chemical linkage between the composite and the cellulose structure. as synthesized composite materials and treated cotton fabrics were characterized by fourier transform infrared spectr ... | 2017 | 28242332 |
| mycotoxin contamination in stored maize and groundnuts based on storage practices and conditions in subhumid tropical africa: the case of kilosa district, tanzania. | experiments were conducted to assess the influence of storage practices on mycotoxin incidences in stored maize and groundnuts in kilosa district, eastern central tanzania. factorial experiments were used to test the effects of processing, storage conditions, and protectants at 3-month intervals for 12 weeks. temperature and relative humidity data were recorded by using data loggers. the differences among the treatment means were compared using tukey's honestly significant difference test at 5% ... | 2016 | 28221960 |
| chitosan immobilized novel peroxidase from azadirachta indica: characterization and application. | in the present paper, a peroxidase was purified from the leaves of a medicinal tree, namely azadirachta indica, to 45.2 folds with overall recovery of 61%. based on the subunit size, the purified peroxidase was suggested to be a monomeric structure of size 50kda and exhibited good thermostability as it was fully stable at 65°c for 1hr and also retained about 73% activity at 70°c till 30min. the substrate affinity was found to be in order of guaiacol>pyrogallol>o-dianisidine. the purified peroxid ... | 2017 | 28215563 |
| oral (systemic) botanical agents for the treatment of psoriasis: a review. | patients with psoriasis often use botanical therapies as part of their treatment. it is important for clinicians to be aware of the current evidence regarding these agents as they treat patients. | 2017 | 28157393 |
| nitric oxide production-inhibitory activity of limonoids from azadirachta indica and melia azedarach. | seventy-three limonoids isolated from three meliaceae plants, azadirachta indica, a. indica var. siamensis, and melia azedarach, or semi-synthesized from the meliaceae limonoids, were evaluated for their inhibitory activity against nitric oxide (no) production in mouse macrophage raw 264.7 cells induced by lipopolysaccharide (lps), as a primary screening test for anti-inflammatory agents. of the compounds tested, 21 compounds exhibited inhibitory activity (ic50 4.6-58.6 μm) without any significa ... | 2017 | 28145090 |
| management of acute skin toxicity with hypericum perforatum and neem oil during platinum-based concurrent chemo-radiation in head and neck cancer patients. | acute skin toxicity is a frequent finding during combined radiotherapy and chemotherapy in head and neck cancer patients. its timely and appropriate management is crucial for both oncological results and patient's global quality of life. we herein report clinical data on the use of hypericum perforatum and neem oil in the treatment of acute skin toxicity during concurrent chemo-radiation for head and neck cancer. a consecutive series of 50 head and neck cancer patients undergoing concomitant rad ... | 2017 | 28101834 |
| stabilization of neem oil biodiesel with corn silk extract during long-term storage. | the current study aimed to evaluate the antioxidant efficiency of different extracts of corn silk. in addition, the impact of corn silk extract on oxidative stability of neem biodiesel during storage was studied. the highest phenolics, dpph radical scavenging and reducing power activities were recorded for methanol-water extract. the longest oxidation stability (10 h) was observed for biodiesel samples blended with 1000 ppm of corn silk extract (cse). at the end of storage period the induction t ... | 2017 | 28100884 |
| comparison of two adsorbent based de-bittering procedures for neem (azadirachta indica a. juss) tea- effect on polyphenols, anti-oxidant capacity, color and volatile profile. | bitterness reduction, especially of foods and beverages containing phytonutrients, is one of the biggest challenges in the food industry because bitterness has a deleterious effect on the taste profile of foods and beverages. neem (azadirachta indica a. juss) is a medicinal tree, indigenous to the indian-subcontinent, whose medicinal properties have led to it being heralded as the tree which is the "panacea for all diseases". however, neem leaf is extremely bitter, in large part due to its limon ... | 2017 | 28091970 |
| the first chloroplast genome sequence of boswellia sacra, a resin-producing plant in oman. | boswellia sacra (burseraceae), a keystone endemic species, is famous for the production of fragrant oleo-gum resin. however, the genetic make-up especially the genomic information about chloroplast is still unknown. here, we described for the first time the chloroplast (cp) genome of b. sacra. the complete cp sequence revealed a circular genome of 160,543 bp size with 37.61% gc content. the cp genome is a typical quadripartite chloroplast structure with inverted repeats (irs 26,763 bp) separated ... | 2017 | 28085925 |
| can toxicants used against cotton mealybug phenacoccus solenopsis be compatible with an encyrtid parasitoid aenasius bambawalei under laboratory conditions? | the cotton mealybug, phenacoccus solenopsis tinsley (sternorrhyncha: pseudococcidae) is a serious pest of various cultivated plants in pakistan. recent reports show that the parasitoid aenasius bambawalei hayat (hymenoptera: encyrtidae) is a good biocontrol agent of the pest. compatibleness is important in any ipm programme, and the insecticide used must have little or no effects on the biological control agent. this study investigated the compatibility of neem treatments and a commercial insect ... | 2017 | 28063085 |
| analysis of anti-bacterial and anti oxidative activity of azadirachta indica bark using various solvents extracts. | herbal medications have been used for relief of symptoms of disease. regardless of the great advances observed in current medicine in recent decades, plants still make a significant contribution to health care. an alarming increase in bacterial strains resistant to a number of antimicrobial agents demands that a renewed effort be made to seek antibacterial agents effective against pathogenic bacteria resistant to or less sensitive to current antibiotics. anti-bacterial activity of azadirachta in ... | 2017 | 28053565 |
| insights on germinability and desiccation tolerance in developing neem seeds (azadirachta indica): role of aos, antioxidative enzymes and dehydrin-like protein. | the germinability and desiccation tolerance (dt) in developing seed are regulated by cellular metabolism involving active oxygen species (aos) and protective proteins during maturation drying. the aim of the present investigation was to unravel the functions of aos (superoxide, h2o2 and oh-radical), antioxidative enzymes (sod, cat and apx) and dehydrin-like proteins in regulating the germinability and dt in undried and artificially desiccated developing neem seeds. germination was first observed ... | 2017 | 28040634 |
| of spheres and squares: can sloterdijk help us rethink the architecture of climate science? | this article explores how different visions and values of science translate into different architectural shapes. i bring peter sloterdijk's 'spherology' to bear on my ethnographic fieldwork at the neem ice core base in greenland, a significant node in the global infrastructure of climate science. i argue that the visual form of the geodesic dome of the camp materializes specific values and visions of this branch of paleoclimate science, which i elaborate vis-a-vis the pragmatic claims of the sci ... | 2016 | 28025912 |
| selectivity of plant extracts for trichogramma pretiosum riley (hym.: trichogrammatidae). | we evaluated the selectivity of three plant extracts with potential insecticidal effects for the parasitoid trichogramma pretiosum riley, which is commonly used in biological pest control. the plant extracts assayed were an acetone extract of toona ciliata m. roem., commercial neem oil, and a nanoencapsulated formulation of neem oil (nc40). the toxicity of the plant extracts to t. pretiosum was evaluated according to the recommendations of the international organization for biological control- i ... | 2017 | 28012368 |
| synthesis and characterization of seaweed cellulose derived carboxymethyl cellulose. | in the present study, cellulose (swc) extracted from green seaweed ulva fasciata was processed to synthesize carboxymethyl cellulose (swcmc). the seaweed cellulose (∼15% dw) was first processed for α cellulose extraction (10.1% on dw) followed by the synthesis and characterization of swcmc. thin films were prepared using commercial cmc (ccmc), swcmc and swcmc-metal nanoparticle (2% wt/v) by solvent evaporation technique. films were studied for molecular weight, degree of carboxylation, viscosity ... | 2017 | 27987874 |
| designing and screening of universal drug from neem (azadirachta indica) and standard drug chemicals against influenza virus nucleoprotein. | different strains of influenza virus are affecting a large number of people worldwide. many synthetic antiviral medicines are available for influenza virus in the market. but still there is a need for the development of universal drugs against these strains of influenza virus. | 2016 | 27986088 |
| neem oil (azadirachta indica a. juss) affects the ultrastructure of the midgut muscle of ceraeochrysa claveri (navás, 1911) (neuroptera: chrysopidae). | cytomorphological changes, by means of ultrastructural analyses, have been used to determine the effects of the biopesticide neem oil on the muscle fibers of the midgut of the predator ceraeochrysa claveri. insects, throughout the larval period, were fed eggs of diatraea saccharalis treated with neem oil at a concentration of 0.5%, 1% or 2%. in the adult stage, the midgut was collected from female insects at two stages of adulthood (newly emerged and at the start of oviposition) and processed fo ... | 2017 | 27939524 |
| preconditioning with azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling. | azadirachta indica is widely distributed in africa, asia and other tropical parts of the world. a. indica (ai) is traditionally used for the treatment of several conditions including cancer, hypertension, heart diseases and skin disorders. intestinal ischaemia-reperfusion is a common pathway for many diseases and may lead to multiple organ dysfunction syndrome and death. | 2017 | 27894590 |
| nimbolide inhibits androgen independent prostate cancer cells survival and proliferation by modulating multiple pro-survival signaling pathways. | prostate cancer is the most prominent cancer in men, experiencing a relapse in disease often express high serum tnf-α levels. it has been correlated with increased cell survival and proliferation of prostate cancer cells. previous studies reported that nimbolide, a terpenoid derived from the leaves and flowers of neem tree inhibits cancer growth through selective modulation of cell signaling pathways linked to inflammation, survival, proliferation, angiogenesis and metastasis. | 2016 | 27889231 |
| allergic contact dermatitis caused by argan oil, neem oil, and mimosa tenuiflora. | | 2016 | 27870098 |
| azadiradione ameliorates polyglutamine expansion disease in drosophila by potentiating dna binding activity of heat shock factor 1. | aggregation of proteins with the expansion of polyglutamine tracts in the brain underlies progressive genetic neurodegenerative diseases (nds) like huntington's disease and spinocerebellar ataxias (sca). an insensitive cellular proteotoxic stress response to non-native protein oligomers is common in such conditions. indeed, upregulation of heat shock factor 1 (hsf1) function and its target protein chaperone expression has shown promising results in animal models of nds. using an hsf1 sensitive c ... | 2016 | 27835876 |
| neem leaf glycoprotein regulates function of tumor associated m2 macrophages in hypoxic tumor core: critical role of il-10/stat3 signaling. | heterogeneous tumor microenvironment (tme), broadly divided into tumor core and peripheral sub-microenvironments, differentially polarize normal macrophages into a different form known as tumor associated m2 macrophages (m2tams) to promote tumor growth. in view of the extensive immune-editing role of nlgp, here, we have observed that nlgp is effective to convert m2tams (cd11b(+)f4/80(high)) to m1 (cd11b(+)f4/80(low)) more prominently in tumor core, along with downregulation of other m2 associate ... | 2016 | 27776244 |
| green synthesis, characterization and drug delivery applications of a novel silver/carboxymethylcellulose - poly(acrylamide) hydrogel nanocomposite. | biodegradable polymeric hydrogels are a unique class of macromolecular networks that can hold a large fraction of an aqueous solvent within their structures. they are particularly suitable for biomedical applications including controlled drug delivery, because of their ability to stimulate biological tissues. many hydrogel-based networks have been designed and fabricated to meet the needs of pharmaceutical and medical fields. the investigation deals with the environment friendly synthesis of bio ... | 2016 | 26546239 |
| azadirachtin, a neem-derived biopesticide, impairs behavioral and hematological parameters in carp (cyprinus carpio). | azadirachtin (aza) is a promisor biopesticide used in organic production and aquaculture. although this compound is apparently safe, there is evidence that it may have deleterious effects on fish. behavioral and hematological tests are grouped into a set of parameters that may predict potential toxicity of chemical compounds. here, we investigate the effects of aza, in the commercial formulation neenmax(™) , on carp (cyprinus carpio) by defining lc50 (96 h), and testing behavioral and hematologi ... | 2016 | 25847134 |
| biodiesel from plant seed oils as an alternate fuel for compression ignition engines-a review. | the modern scenario reveals that the world is facing energy crisis due to the dwindling sources of fossil fuels. environment protection agencies are more concerned about the atmospheric pollution due to the burning of fossil fuels. alternative fuel research is getting augmented because of the above reasons. plant seed oils (vegetable oils) are cleaner, sustainable, and renewable. so, it can be the most suitable alternative fuel for compression ignition (ci) engines. this paper reviews the availa ... | 2016 | 27743330 |
| neem oil poisoning - case report of an adult with toxic encephalopathy. | | 2016 | 27728581 |
| synergistic antidiabetic activity of vernonia amygdalina and azadirachta indica: biochemical effects and possible mechanism. | | 2016 | 27720513 |
| a comparative evaluation on antimicrobial effect of honey, neem leaf extract and sodium hypochlorite as intracanal irrigant: an ex-vivo study. | the major determinant of the success of root canal treatment depends on meticulous disinfection of the root canal using intracanal irrigants. the most commonly used root canal irrigant is sodium hypochlorite which has disadvantages of cytotoxicity and unpleasant taste. so there is a need to identify a more biocompatible root canal irrigant. | 2016 | 27656571 |
| canadian arctic sea ice reconstructed from bromine in the greenland neem ice core. | reconstructing the past variability of arctic sea ice provides an essential context for recent multi-year sea ice decline, although few quantitative reconstructions cover the holocene period prior to the earliest historical records 1,200 years ago. photochemical recycling of bromine is observed over first-year, or seasonal, sea ice in so-called "bromine explosions" and we employ a 1-d chemistry transport model to quantify processes of bromine enrichment over first-year sea ice and depositional t ... | 2016 | 27650478 |
| the effect of green synthesized cuo nanoparticles on callogenesis and regeneration of oryza sativa l. | in this study, we have investigated the effect of copper oxide nanoparticles (cuo-nps) on callogenesis and regeneration of oryza sativa l (super basmati, basmati 2000, basmati 370, and basmati 385). in this regard, cuo-nps have been bio-synthesized via azadirachta indica leaf extract. scanning electron microscope (sem) analysis depicts average particle size of 40 ± 5 nm with highly homogenous and spherical morphology. x-ray diffraction (xrd) and fourier transform infrared spectroscopy (ftir) hav ... | 2016 | 27630655 |
| synthesis, characterization, biocompatible and anticancer activity of green and chemically synthesized silver nanoparticles - a comparative study. | silver nanoparticles (agnps) are superior cluster of nanomaterials that are recently recognized for their different applications in various pharmaceutical and clinical settings. the objective of this work deals with novel method for biosynthesis of agnps using azadirachta indica (neem) leaf extract as reducing agent. these bio and chemical synthesized nanoparticles were characterized with the help of uv-vis spectroscopy, nanotarc, dynamic light scattering (dls), zeta potential (zp), transmission ... | 2016 | 27621034 |
| damage patterns, monitoring, and management of procontarinia mangiferae (diptera: cecidomyiidae) in pakistan. | since 2005, mango has been damaged by a group of new pests, the gall midges, in all mango-growing areas of pakistan. little is known about these pests in pakistan. in this report, we present information on the occurrence, damage patterns, methods for monitoring, and management of procontarinia mangiferae (felt), a mango gall midge found in the country. at the study site (rahim yar khan, a district of the province punjab, pakistan), the pest was active from january/february to april as eggs, larv ... | 2016 | 27616764 |
| toxic effects of the neem oil (azadirachta indica) formulation on the stink bug predator, podisus nigrispinus (heteroptera: pentatomidae). | this research investigated the effects of neem oil on mortality, survival and malformations of the non-target stink bug predator, podisus nigrispinus. neurotoxic and growth inhibitor insecticides were used to compare the lethal and sublethal effects from neem oil on this predator. six concentrations of neem oil were topically applied onto nymphs and adults of this predator. the mortality rates of third, fourth, and fifth instar nymphs increased with increasing neem oil concentrations, suggesting ... | 2016 | 27596436 |
| allometric models and aboveground biomass stocks of a west african sudan savannah watershed in benin. | the estimation of forest biomass changes due to land-use change is of significant importance for estimates of the global carbon budget. the accuracy of biomass density maps depends on the availability of reliable allometric models used in combination with data derived from satellites images and forest inventory data. to reduce the uncertainty in estimates of carbon emissions resulting from deforestation and forest degradation, better information on allometric equations and the spatial distributi ... | 2016 | 27594897 |
| the antioxidant potential of azadirachta indica ameliorates cardioprotection following diabetic mellitus-induced microangiopathy. | cardiac complications associated with diabetes mellitus have become major cause of concern. antidiabetic drugs, with varied mode of action, are although available, apprehensions exist for their limited action or side effects upon prolonged use. efforts are therefore inclined toward finding other alternatives. the present study was, thus, undertaken to evaluate the cardioprotective effect of azadirachta indica (ai) on microangiopathic changes in rat model of diabetes. | 2016 | 27563227 |
| a new sucrase enzyme inhibitor from azadirachta indica. | sucrase enzyme inhibitor considered as an oral anti-diabetic therapy that delays the absorption of eaten carbohydrates, reducing the postprandial glucose and insulin peaks to reach normoglycemia. | 2016 | 27563214 |
| reconstructing the last interglacial at summit, greenland: insights from gisp2. | the eemian (last interglacial, 130-115 ka) was likely the warmest of all interglacials of the last 800 ka, with summer arctic temperatures 3-5 °c above present. here, we present improved eemian climate records from central greenland, reconstructed from the base of the greenland ice sheet project 2 (gisp2) ice core. our record comes from clean, stratigraphically disturbed, and isotopically warm ice from 2,750 to 3,040 m depth. the age of this ice is constrained by measuring ch4 and δ(18)o of o2, ... | 2016 | 27528680 |
| head lice in progress: what could/should be done-a report on an in vivo and in vitro field study. | head lice infections are a growing problem in the light of increasing migration of large population as well as the increasing current refugee flows and concomitant poor hygienic conditions. these infections are associated with a significantly reduced quality of life and frequent medical consultations. the approved drugs for the treatment of head lice infections have some disadvantages in the treatment despite their good efficacy. in addition to irritant-toxic substances that can cause adverse re ... | 2016 | 27481171 |
| evaluation of nano structured slow release fertilizer on the soil fertility, yield and nutritional profile of vigna radiata. | the excessive use of fertilizers and pesticides has distorted soil composition, fertility and integ-rity with relevant and non-desirable environmental and ecological consequences. a strategy was designed to prepare a nano structured slow release fertilizer system that delivers nutrients and plant growth promoting rhizobacteria simultaneously. slow release nano phosphate and potash fertilizer was prepared by blending the nano emulsion of fertilizer with neem cake and pgpr. | 2016 | 27465293 |
| synthesis of iron nanoparticles using azadirachta indica extract and its catalytic activity toward nitrophenol reduction. | a simple, hasty and eco-friendly approach for the synthesis of iron nanoparticles has been developed using the medicinally important azadirachta indica extract, which act as both reducing and stabilizing agent. the formation and morphological properties of iron nanoparticles as a function of metallic precursor and azadirachta indica extract concentration have been investigated. the influence of solvent over the size and texture of iron nanoparticles has also been evaluated in detail. the thermal ... | 2016 | 27455665 |
| melanogenesis-inhibitory activities of isomeric c-seco limonoids and deesterified limonoids. | treatment of eight c-seco limonoids including six of salannin-type, 1 - 6, and two of nimbin-type, 7 and 8, with a combination of bf3 · et2 o and iodide ion yielded the isomeric c-seco derivatives, i.e., six isosalannins, 1a - 6a, and two isonimbins, 7a and 8a, respectively. ohchinin (1) was further subjected to lialh4 reduction which yielded a deesterified trihydroxy limonoid, nimbidinol (9). in addition, ten limonoids including seven of azadirone-type, 10 - 16, and three of gedunin-type, 17 - ... | 2016 | 27450797 |
| comparative analysis of the terpenoid biosynthesis pathway in azadirachta indica and melia azedarach by rna-seq. | azadirachta indica (neem) is the only source of azadirachtin, which is known for its insecticide activity. melia azedarach is a related species of a. indica, widely distributed in the south of china. in this study, the leaf transcriptomes of these two meliaceae plants were sequenced. more than 40 million clean reads were generated from each library. about 80 % of a. indica reads were mapped to the neem genome, while 93 % of m. azedarach reads were mapped to its assembled transcripts and unigenes ... | 2016 | 27390659 |
| azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo. | terpenoids were isolated using chromatographic purification through solvent purification technique and identified as azadirone (1), epoxyazadiradione (2) azadiradione (3) gedunin (4) nimbin (5) salannin (6) azadirachtin a (7) and azadirachtin b (8) from azadirachta indica. out of eight compounds, only three compounds had osteogenic activity and enhanced osteoblast proliferation, differentiation and mineralization in osteoblast cells. active compounds stimulated osteogenic genes alp, runx-2 and o ... | 2016 | 27317644 |
| sequestering of as(iii) and as(v) from wastewater using a novel neem leaves/mnfe2o4 composite biosorbent. | an arsenic biosorbent comprising neem leaves (nl) and mnfe2o4 particles was developed and its removal potential was investigated. physicochemical analysis of the nl/mnfe2o4 composite (mnl) was performed for the brunauer, emmett and teller surface area, fourier transform infrared spectra (ft-ir), and scanning electron microscopy-energy-dispersive x-ray (edx). the following parameters were optimized: ph, biosorbent dose, contact time, temperature, and initial arsenic concentration. the optimum ph ... | 2016 | 27284978 |
| nimbolide inhibits nuclear factor-кb pathway in intestinal epithelial cells and macrophages and alleviates experimental colitis in mice. | nimbolide is a limonoid extracted from neem tree (azadirachta indica) that has antiinflammatory properties. the effect of nimbolide on the nuclear factor-kappa b (nf-κb) pathway in intestinal epithelial cells (iecs), macrophages and in murine colitis models was investigated. the iec colo 205, the murine macrophage cell line raw 264.7, and peritoneal macrophages from interleukin-10-deficient (il-10(-/-) ) mice were preconditioned with nimbolide and then stimulated with tumor necrosis factor-α (tn ... | 2016 | 27270592 |
| combination of nimbolide and tnf-α-increases human colon adenocarcinoma cell death through jnk-mediated dr5 up- regulation. | tumor necrosis factor (tnf-α), an inflammatory cytokine that plays an important role in the control of cell proliferation, differentiation, and apoptosis, has previously been used in anti-cancer therapy. however, the therapeutic applications of tnf-α are largely limited due to its general toxicity and anti-apoptotic influence. to overcome this problem, the present study focused on the effect of active constituents isolated from a medicinal plant on tnf-α-induced apoptosis in human colon adenocar ... | 2016 | 27268643 |
| neem tree (azadirachta indica) extract specifically suppresses the growth of tumors in h22-bearing kunming mice. | recently, neem tree (azadirachta indica) extract (nte) has been reported to have various antitumor activities against gastric, breast, prostate, and skin cancer, respectively. the current study was designed to evaluate the effect of nte on hepatic cancer in a mouse model. the possible side effects elicited by nte were also evaluated. the components in nte were analyzed by liquid chromatography-mass spectrometry (lc-ms). h22 cells-bearing kumming mice were generated by injecting h22 cells subcuta ... | 2017 | 27248120 |
| erratum to: apoptosis mediated leishmanicidal activity of azadirachta indica bioactive fractions is accompanied by th1 immunostimulatory potential and therapeutic cure in vivo. | | 2016 | 27234305 |
| ethnobotanical uses of neem (azadirachta indica a.juss.; meliaceae) leaves in bali (indonesia) and the indian subcontinent in relation with historical background and phytochemical properties. | neem (azadirachta indica; meliaceae) is widely known for its cold pressed seed oil, mainly used as insecticide, but also for cosmetic, medicinal and agricultural uses. the seed oil is widely employed in the indian subcontinent, and the leaves seem to have a lower relevance, but the ethnobotanical information of bali (indonesia) considers the utilisation of leaves for medicinal properties. | 2016 | 27178630 |
| absence of cd4(+) t cell help generates corrupt cd8(+) effector t cells in sarcoma-bearing swiss mice treated with nlgp vaccine. | one of the prime objectives of cancer immunology and immunotherapy is to study the issues related to rescue and/or maintenance of the optimum effector cd8(+) t cell functions by minimizing tumor-induced negative factors. in this regard the influence of host intrinsic cd4(+) helper t cells towards generation and maintenance of cd8(+) effector t cells appears controversial in different experimental settings. therefore, the present study was aimed to re-analyze the influence of cd4(+) helper t cell ... | 2016 | 27178306 |
| an improved genome assembly of azadirachta indica a. juss. | neem (azadirachta indica a. juss.), an evergreen tree of the meliaceae family, is known for its medicinal, cosmetic, pesticidal and insecticidal properties. we had previously sequenced and published the draft genome of a neem plant, using mainly short read sequencing data. in this report, we present an improved genome assembly generated using additional short reads from illumina and long reads from pacific biosciences smrt sequencer. we assembled short reads and error-corrected long reads using ... | 2016 | 27172223 |
| insecticidal activity of neem oil against gyropsylla spegazziniana (hemiptera: psyllidae) nymphs on paraguay tea seedlings. | gyropsylla spegazziniana (paraguay tea ampul) is one of the most important pests of paraguay tea plants, and prohibition of synthetic insecticide use for control of this pest has led to the search for alternative methods. this laboratory study aimed to compare different control strategies for g. spegazziniana, utilizing a commercial neem seed oil product. paraguay tea seedlings were treated with neem oil solution both pre- and post-infestation with 5th instar nymphs. the systemic action of neem ... | 2017 | 27143053 |
| natural agents used in chemoprevention of aerodigestive and gi cancers. | aerodigestive cancers are on an increasing level in both occurrence and mortality. a major cause in many of these cancers is disruption of the inflammatory pathway, leading to increased cell proliferation, and epigenetic silencing of normal regulatory genes. here we review the research on several natural products: silibinin, silymarin, quercetin, neem & nimbolide, gingerol, epigallatecatechin-3- gallate, curcumin, genistein and resveratrol conducted on aerodigestive cancers. these types of cance ... | 2016 | 27134816 |
| use of plant extracts for tea pest management in india. | india is the second largest producer of black tea in the world. the biggest challenge for tea growers of india nowadays is to combat pests and diseases. tea crop in india is infested by not less than 720 insect and mite species. at least four sucking pests and six chewing pests have well established themselves as regular pests causing substantial damage to this foliage crop. various synthetic pesticides are widely used for the management of tea pests in india. applications of such large quantity ... | 2016 | 27102124 |
| lack of genotoxic potential of pesticides, spinosad, imidacloprid and neem oil in mice (mus musculus). | pesticides, spinosad, imidacloprid and neem oil are widely used both in residential and agricultural environments because of its broad spectrum insecticidal activity and effectiveness. the present study was undertaken to estimate genotoxicity of formulations of some pesticides in mice. three pesticides of diverse group studied were spinosad (45% w/v), imidacloprid (17.8%, w/v) and neem oil. animals were exposed 37, 4.5 and 50 mg kg⁻¹ b.wt. for spinosad, imidacloprid and neem oil, respectively, t ... | 2016 | 27097450 |
| morphological and biochemical changes in azadirachta indica from coal combustion fly ash dumping site from a thermal power plant in delhi, india. | the foliar and biochemical traits of azadirachta indica a. juss from fly ash (fa) dumping site in badarpur thermal power plant (btpp) new delhi, india was studied. three different experimental sites were selected at different distances from the thermal power plant. ambient suspended particulate matter (spm) and plant responses such as leaf pigments (chlorophyll a, chlorophyll b, and carotenoids), total chlorophyll, net photosynthetic rate, stomatal index (si), stomatal conductance (sc), intercel ... | 2016 | 27077968 |
| azadirachta indica plant-assisted green synthesis of mn3o4 nanoparticles: excellent thermal catalytic performance and chemical sensing behavior. | the leaf extract of azadirachta indica (neem) plant was utilized as reducing agent for the green synthesis of mn3o4 nanoparticles (nps). the crystalline analysis demonstrated the typical tetragonal hausmannite crystal structure of mn3o4, which confirmed the formation of mn3o4 nps without the existence of other oxides. green synthesized mn3o4 nps were applied for the catalytic thermal decomposition of ammonium perchlorate (ap) and as working electrode for fabricating the chemical sensor. the exce ... | 2016 | 27038784 |
| therapeutics role of azadirachta indica (neem) and their active constituents in diseases prevention and treatment. | neem (azadirachta indica) is a member of the meliaceae family and its role as health-promoting effect is attributed because it is rich source of antioxidant. it has been widely used in chinese, ayurvedic, and unani medicines worldwide especially in indian subcontinent in the treatment and prevention of various diseases. earlier finding confirmed that neem and its constituents play role in the scavenging of free radical generation and prevention of disease pathogenesis. the studies based on anima ... | 2016 | 27034694 |
| anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development. | nimbolide is one of the main components in the leaf extract of azadirachta indica (a. indica). accumulating evidence from various in vitro and in vivo studies indicates that nimbolide possesses potent anticancer activity against several types of cancer and also shows potential chemopreventive activity in animal models. the main mechanisms of action of nimbolide include anti-proliferation, induction of apoptosis, inhibition of metastasis and angiogenesis, and modulation of carcinogen-metabolizing ... | 2016 | 27027349 |
| potential of neem (azadirachta indica l.) for prevention and treatment of oncologic diseases. | throughout time, plants have often displayed medicinal properties that have been underscored. we often derive medicines involved in treating cancer from components in plants. azadirachta indica, commonly known as "neem", has been used to treat different ailments in many asian countries. due to its widespread beneficial uses, a. indica has often been referred to as "the wonder tree" or "nature's drug store". various parts of this plant, including, leaves, flowers, fruits, seeds, roots, bark and o ... | 2016 | 27019417 |
| therapeutic and safety evaluation of combined aqueous extracts of azadirachta indica and khaya senegalensis in chickens experimentally infected with eimeria oocysts. | coccidiosis is a disease of economic importance in poultry causing morbidity and mortality. reports show that azadirachta indica and khaya senegalensis have been used individually in the treatment of avian coccidiosis. we thus investigated the efficacy and safety of the combined aqueous extracts of these plants for the treatment of experimentally induced coccidiosis in broiler chickens using oocyst count, oxidative stress biomarkers, serum biochemistry, histology, and haematological parameters. ... | 2016 | 26989496 |
| gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway. | the lack of efficient treatment options for pancreatic cancer highlights the critical need for the development of novel and effective chemotherapeutic agents. the medicinal properties found in plants have been used to treat many different illnesses including cancers. this study focuses on the anticancer effects of gedunin, a natural compound isolated from azadirachta indica. | 2016 | 26988754 |
| in vivo antimicrobial efficacy of 6% morinda citrifolia, azadirachta indica, and 3% sodium hypochlorite as root canal irrigants. | to evaluate and compare the antimicrobial efficacy of 6% morinda citrifolia, azadirachta indica, and 3% sodium hypochlorite (naocl) as root canal irrigants. | 2017 | 26929692 |
| nimbolide, a neem limonoid inhibits phosphatidyl inositol-3 kinase to activate glycogen synthase kinase-3β in a hamster model of oral oncogenesis. | glycogen synthase kinase-3β (gsk-3β), a serine/threonine kinase is frequently inactivated by the oncogenic signalling kinases pi3k/akt and mapk/erk in diverse malignancies. the present study was designed to investigate gsk-3β signalling circuits in the 7,12-dimethylbenz[a]anthracene (dmba)-induced hamster buccal pouch (hbp) carcinogenesis model and the therapeutic potential of the neem limonoid nimbolide. inactivation of gsk-3β by phosphorylation at serine 9 and activation of pi3k/akt, mapk/erk ... | 2016 | 26902162 |
| effectiveness of azadirachta indica (neem) mouthrinse in plaque and gingivitis control: a systematic review. | the aim of this systematic review was to evaluate the effectiveness of azadirachta indica (neem)-based herbal mouthrinse in improving plaque control and gingival health. | 2017 | 26876277 |
| morphological alterations in salivary glands of rhipicephalus sanguineus ticks (acari: ixodidae) exposed to neem seed oil with known azadirachtin concentration. | neem (azadirachta indica) has attracted the attention of researchers worldwide due to its repellent properties and recognized effects on the morphology and physiology of arthropods, including ticks. therefore, this study aimed to demonstrate the effects of neem seed oil enriched with azadirachtin on salivary glands of rhipicephalus sanguineus ticks, targets of great veterinary interest because of their ability to transmit pathogens to dogs. for this, r. sanguineus semi-engorged females were subj ... | 2016 | 26852009 |
| neem leaf glycoprotein promotes dual generation of central and effector memory cd8(+) t cells against sarcoma antigen vaccine to induce protective anti-tumor immunity. | we have previously shown that neem leaf glycoprotein (nlgp) mediates sustained tumor protection by activating host immune response. now we report that adjuvant help from nlgp predominantly generates cd44(+)cd62l(high)ccr7(high) central memory (tcm; in lymph node) and cd44(+)cd62l(low)ccr7(low) effector memory (tem; in spleen) cd8(+) t cells of swiss mice after vaccination with sarcoma antigen (sarag). generated tcm and tem participated either to replenish memory cell pool for sustained disease f ... | 2016 | 26851529 |
| knowledge, attitude, and practice regarding cervical cancer among rural community women in northeast thailand. | cervical cancer is the second most common malignancy among women worldwide, and women of reproductive age in thailand. however, information on the behavior regarding cervical cancer in rural community thailand is sparse. | 2016 | 26838259 |
| nimbolide inhibits pancreatic cancer growth and metastasis through ros-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition. | the mortality and morbidity rates of pancreatic cancer are high because of its extremely invasive and metastatic nature. its lack of symptoms, late diagnosis and chemo-resistance and the ineffective treatment modalities warrant the development of new chemo-therapeutic agents for pancreatic cancer. agents from medicinal plants have demonstrated therapeutic benefits in various human cancers. nimbolide, an active molecule isolated from azadirachta indica, has been reported to exhibit several medici ... | 2016 | 26804739 |
| effect of neem containing toothpaste on plaque and gingivitis--a randomized double blind clinical trial. | the present study was designed to assess the effect of toothpaste containing neem on plaque and gingivitis. | 2015 | 26718296 |
| ultrasound-assisted extraction of azadirachtin from dried entire fruits of azadirachta indica a. juss. (meliaceae) and its determination by a validated hplc-pda method. | azadirachta indica a. juss., also known as neem, is a meliaceae family tree from india. it is globally known for the insecticidal properties of its limonoid tetranortriterpenoid derivatives, such as azadirachtin. this work aimed to optimize the azadirachtin ultrasound-assisted extraction (uae) and validate the hplc-pda analytical method for the measurement of this marker in neem dried fruit extracts. box-behnken design and response surface methodology (rsm) were used to investigate the effect of ... | 2016 | 26717816 |
| beta cell regenerating potential of azadirachta indica (neem) extract in diabetic rats. | this study evaluated the ability of 0.8% neem leaf extract (nle) to treat diabetes mellitus by assessing its effects on blood glucose, insulin levels and islet morphology in streptozotocin (stz)-induced diabetic sprague-dawley rats. | 2015 | 26716795 |