| [dyspepsia and helicobacter pylori infection. a study of a population of workers]. | we studied 102 workers in a mechanical factory. all subjects were tested by a questionnaire screening dyspeptic symptoms in the last three months, their frequency, absenteeism period, spontaneous drugs intake and a consultant gastroenterologist request. all subjects were tested for specific igg against helicobacter pylori with immunoassay elisa. dyspepsia was present in 61% of cases. positivity for helicobacter pylori infection was in 76%, absenteeism in 82%, consultant request in 21% of dyspept ... | 1991 | 1845464 |
| [occurrence of campylobacter pylori in gastric mucosa and selected parameters of cell-mediated immunity in patients with duodenal ulcer and individuals with non-ulcerative dyspepsia]. | the study was aimed at investigating a relationship between campylobacter pylori infection in the gastric mucosa and selected parameters of cell-mediated immunity in patients with duodenal ulcer and the individuals with non-ulcerative dyspepsia. a relationship between campylobacter pylori and gastritis has also been studied. endoscopic and immunological tests were carried out in the group of 45 patients, including 14 patients with duodenal ulcer and 29 with non-ulcerative dyspepsia. specimens of ... | 1991 | 1845737 |
| soluble surface proteins from helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism. | the inflammatory lesions associated with helicobacter pylori gastritis and duodenitis contain large numbers of mononuclear cells. the close proximity of h. pylori to gastric mucosa suggests that the organism interacts with mononuclear cells, thereby modulating the inflammatory response. to investigate the role of monocytes/macrophages in this response, we examined the effect of whole h. pylori bacteria, h. pylori surface proteins, and h. pylori lipopolysaccharide (lps) on purified human monocyte ... | 1991 | 1847939 |
| helicobacter pylori--our knowledge is growing. | | 1991 | 1852675 |
| plasma gastrin, daytime intragastric ph, and nocturnal acid output before and at 1 and 7 months after eradication of helicobacter pylori in duodenal ulcer subjects. | nine patients with helicobacter pylori-related antral gastritis and history of duodenal ulceration were studied before and at 1 and 7 months after eradication of the infection by a 4-week course of tripotassium dicitrato bismuthate, metronidazole, and amoxycillin. the median basal gastrin concentration before eradication was 30 ng/l (range, 20-60) and fell to 20 ng/l (5-20) at 1 month (p less than 0.02) and 15 ng/l (5-20) at 7 months (p less than 0.01) after eradication. the integrated gastrin r ... | 1991 | 1853158 |
| a comparison of symptoms between non-ulcer dyspepsia patients positive and negative for helicobacter pylori. | the role of helicobacter pylori infection in the symptom complex associated with non-ulcer dyspepsia is uncertain, despite the presence of the organism in a high proportion of these patients. in order to exclude physician bias in history taking, 18 patients (9 female) diagnosed as non-ulcer dyspepsia, after endoscopy and gallbladder ultrasonography, underwent computer interrogation using the glasgow diagnostic system for dyspepsia (gladys). five antral and 3 fundal endoscopic biopsies from these ... | 1991 | 1853492 |
| helicobacter pylori infection in elderly dyspeptic patients. | the association between helicobacter pylori (hp) and gastritis is well established. as there is evidence that hp infection increases with age we reviewed the clinicopathological records of 119 consecutive patients aged 65-85 years (mean 71.1 years) on whom gastroscopy had been performed for dyspeptic symptoms. all patients had two antral biopsies--one was assessed for histological evidence of gastritis and the other was independently assessed for evidence of hp infection. thirty-six patients (30 ... | 1991 | 1853792 |
| effect of triple therapy (antibiotics plus bismuth) on duodenal ulcer healing. a randomized controlled trial. | to determine whether antimicrobial therapy for helicobacter pylori infection accelerates the healing of duodenal ulcers. | 1991 | 1854110 |
| bactericidal effect of amoxicillin on helicobacter pylori in an in vitro model using epithelial cells. | the treatment of helicobacter pylori with antimicrobial agents has largely been ineffective, and susceptibility results are in disagreement with those obtained by standard in vitro testing. the bactericidal effect of amoxicillin was tested in an in vitro model by using sessile bacteria attached to hep-2 cells; this bactericidal effect was compared with that against planktonic bacteria. viable cell counts were performed by standard procedures after 1, 6, and 24 h of contact with the antibiotic at ... | 1991 | 1854168 |
| [secretory immunoglobulin a and pyloric helicobacteriosis in patients with duodenal ulcer]. | 57 patients with duodenum ulcer were examined. secretory immunoglobulin a (siga) was determined by an immunofluorescent method in the gastric and duodenum mucosa depending on the population size of pyloric helicobacter (hb). the frequency of siga detection in the gastric mucosa depends on the hb population size: when it is considerable siga was not detected in 41% cases. siga was detected in the gastric mucosa without pathological lesions in 85% cases, in atrophic gastritis in 70% and in superfi ... | 1991 | 1854274 |
| helicobacter pylori infection and gastric cancer. | | 1991 | 1855030 |
| helicobacter pylori infection and duodenal ulcer. | | 1991 | 1855031 |
| exposure to n-nitrosamines and other risk factors for gastric cancer in costa rican children. | the hypothesis that endogenous chemical nitrosation in the normal stomach in early life could play a crucial role in inducing chronic atrophic gastritis/intestinal metaplasia in later life was tested by applying the n-nitrosoproline (npro) test to 12-h urine samples from about 50 children (aged 8-14 years) living in high- and low-risk areas for stomach cancer. the median values of npro and the sum of four nitrosamino acids analysed were 0.28-0.84 micrograms/12 h and 0.75-1.75 micrograms/12 h, re ... | 1991 | 1855842 |
| the etiology of gastric cancer. | we review recent evidence concerning risk factors for gastric cancer. an overview of analytical studies shows convincing evidence of a protective effect of fruit and vegetables. the specific protective constituents have not been firmly established, but micronutrients, especially ascorbic acid, are probably of importance. other dietary factors that show a consistent pattern of effect in different studies are the moderate risks associated with high intake of preserved foods and salt. evidence also ... | 1991 | 1855854 |
| helicobacter pylori and gastric histamine concentrations. | an enzyme isotopic assay was used to determine the histamine concentration in the gastric mucosa of patients positive for helicobacter pylori with (n = 11) and without duodenal ulceration (n = 9) and in negative controls (n = 7). a significant difference was observed when the histamine content of h pylori negative subjects was compared with that of positive patients. on the other hand, there was no significant difference in histamine concentration between h pylori positive patients with duodenal ... | 1991 | 1856297 |
| characterization of the helicobacter pylori urease and purification of its subunits. | helicobacter pylori (formerly campylobacter pylori) is the causative agent of gastritis in man. helicobacter pylori cells contain a large amount of an extremely active urease (e.c.3.5.1.5). this enzyme is suspected to be a virulence factor since the ammonium ion produced from urea may be responsible for tissue injury and/or survival of h. pylori in the gastric environment. helicobacter pylori urease, native relative molecular mass approximately 600,000, was purified by agarose gel filtration and ... | 1991 | 1857197 |
| helicobacter pylori in migrants. | | 1991 | 1857849 |
| helicobacter pylori. | since 1983, rapid advances in the knowledge of helicobacter pylori have given new insights into the pathogenesis of upper gastrointestinal diseases. several methods are now available for the diagnosis of the infection. antimicrobial therapy has emerged as a new and effective treatment for peptic ulcer disease in a proportion, as yet to be determined, of patients in the caribbean. | 1991 | 1858368 |
| helicobacter pylori and nsaids--more questions than answers. | | 1991 | 1858749 |
| five-day bismuth-free triple therapy for the eradication of helicobacter pylori and reduction of duodenal ulcer relapse. | previous studies have demonstrated that the eradication of helicobacter pylori (h. pylori) is associated with a significant reduction of the rate of duodenal ulcer (du) relapse. the aim of this study was to assess the long-term effect of a bismuth-free triple therapy on the eradication of h. pylori and reduction of du relapse. after informed consent, 61 patients with endoscopically proven du and h. pylori infection detected on 14c-urea breath test (bt) were included in the study. all patients re ... | 1991 | 1858763 |
| helicobacter pylori-negative duodenal ulcer. | purpose patients and methods: helicobacter pylori (hp) is present in more than 90% of duodenal ulcers (dus). to investigate the pathophysiology in those patients with du who are hp-negative compared with those who are hp-positive, we interviewed consecutive patients prior to endoscopy regarding factors often associated with ulcer disease. at esophagogastroduodenoscopy, antral biopsy specimens were obtained for urease test, culture, and warthin starry staining for hp in all patients with du who d ... | 1991 | 1858824 |
| helicobacter pylori and associated gastroduodenal diseases. review article. | helicobacter pylori is a microaerophilic, gram-negative, spiral rod, the role of which in different gastric diseases has been investigated worldwide since the beginning of the 1980s. h. pylori has been shown to be the causative agent in active chronic gastritis, and it is regularly found in patients endoscopied for duodenal ulcer. the bacterium is also frequently isolated from persons with gastric ulcer, gastric carcinoma and non-ulcer dyspepsia. apart from cultivation of the bacterium, other di ... | 1991 | 1859643 |
| serum immune response to helicobacter pylori in children: epidemiologic and clinical applications. | antibody responses to helicobacter pylori were measured by a solid-phase whole-cell enzyme-linked immunosorbent assay in 150 children and adolescents; in 47 consecutive children undergoing upper gastrointestinal endoscopy, including 17 with h. pylori infection before and after antimicrobial treatment; and in 46 family members of the infected children. abnormal levels of either igg or iga were found in 6% of the 150 children. in the latter group the prevalence of h. pylori seropositivity increase ... | 1991 | 1861206 |
| can diagnosis of helicobacter pylori be rapid and yet sensitive? | diagnostic accuracy of 5 tests viz., endoscopy, rapid urease, 24 hours urease, culture and histology, were evaluated in the detection of helicobacter pylori (h. pylori) infection in 50 patients undergoing upper g.i. endoscopy. endoscopic evidence of gastritis to predict h. pylori infection was 50% specific and 46% sensitive. rapid and 24 hours urease test and culture were 100% specific when compared with histology and their sensitivity was 71%, 62% and 21% respectively. of the three 100% specifi ... | 1991 | 1861352 |
| seroepidemiology of helicobacter pylori infection in india. comparison of developing and developed countries. | helicobacter pylori (previously campylobacter pylori) is now accepted as the major cause of type b gastritis and thus what is known about the epidemiology of type b gastritis can reasonably be transferred to h. pylori. we used a specific elisa for anti-h. pylori igg to study the prevalence of h. pylori infection in a population of lower socioeconomic class from hyderabad, india. the results from india were compared to studies from other parts of the world. two hundred thirty-eight individuals ag ... | 1991 | 1864201 |
| severity of helicobacter-induced gastric injury correlates with gastric juice ammonia. | we postulated that ammonia produced by helicobacter pylori may contribute to gastric mucosal injury. this hypothesis was evaluated in helicobacter-positive patients with chronic renal failure in whom a high urea concentration might amplify this phenomenon. gastric urea and ammonia were measured, and the severity of gastritis was evaluated by counting mononuclear and polymorphonuclear cells. high gastric ammonia and low urea in helicobacter-positive patients, and the converse in helicobacter-nega ... | 1991 | 1864202 |
| antibacterial activity of pantoprazole and omeprazole against helicobacter pylori. | | 1991 | 1864281 |
| gastritis due to spiral shaped bacteria other than helicobacter pylori: clinical, histological, and ultrastructural findings. | an intensive histological search for helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. the clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients (87.2%) complaining of upper abdominal discomfort. five patients (12.8%) had chronic gastritis and 34 (87.2%) chronic active gastritis. the organisms were seen by light microscopy ... | 1991 | 1864530 |
| high prevalence of helicobacter pylori infection and histologic gastritis in asymptomatic hispanics. | in this study, we estimated the prevalence of helicobacter pylori infection and histologic gastritis in 58 asymptomatic hispanic adult volunteers (mean age, 41 years; 59% male) by endoscopic biopsy of the upper gastrointestinal tract. forty-six subjects (79%) were found to harbor h. pylori in gastric biopsies, and all had histologic gastritis. four other subjects were found to have gastritis in the absence of h. pylori. similar prevalences of h. pylori and gastritis were noted in all age groups ... | 1991 | 1864929 |
| harnessing of urease activity of helicobacter pylori to induce self-destruction of the bacterium. | eradication of helicobacter pylori with currently available antibacterial agents is unsatisfactory due to the risk of side-effects and the emergence of resistance. the organism rapidly dies in vitro in the presence of urea at ph 6. when incubated in citrate buffer (ph 6) plus urea (10 mm) the five minute survival was 26% compared with 96% without urea and the survival progressively decreased with increasing urea concentrations, being only 9% in 50 mm urea. the bactericidal effect depended on ph ... | 1991 | 1864988 |
| helicobacter pylori serology using specimens collected on filter paper. | a simple method for the collection of blood specimens on filter paper for serology of helicobacter pylori was devised. blood was freshly applied to small whatman 3 mm filter paper and allowed to dry. serological activity, as measured by reactivity to h pylori antigens (amrad, australia), was retained after storage for one month at both room temperature and at 4 degrees c. this technique eliminates formal venepuncture, separation of sera, and arduous packaging of specimens to be sent to the labor ... | 1991 | 1864992 |
| gastritis associated with infection by helicobacter pylori in humans: geographical differences. | previous studies have indicated that infection rates of helicobacter pylori are influenced by geographical factors. the present studies evaluate the characteristics of gastritis, associated with infection by h. pyrlori, and demonstrate relationships between different geographical locations and the extent of inflammatory cell accumulation in the gastric mucosa. gastric biopsy specimens were obtained from patients infected with h. pylori at three clinical sites (two from north america and one from ... | 1991 | 1866589 |
| clinical trials as etiologic research tools in helicobacter-associated gastritis. | the role of clinical trials as tools to elucidate the etiology of chronic gastritis is discussed. three areas are briefly explored. the first one concerns the classification of chronic gastritis, a constellation of interconnected nosologic entities. the second refers to the histopathologic factors of chronic gastritis; preliminary results show that clearance of helicobacter pylori decreases the inflammatory infiltrate and suggest that h. pylori alters cell ploidy. the third area refers to the mu ... | 1991 | 1866590 |
| molecular techniques for studying the epidemiology of infection by helicobacter pylori. | the efficacy of one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page) of whole-cell protein patterns for fingerprinting isolates of helicobacter pylori was assessed by means of computerized numerical analysis. virtually all strains were found to have unique, stable, and reproducible protein profiles. the application of this technique to a collection of isolates from eight patients showed clearly that each harboured a distinct strain that was present before treatme ... | 1991 | 1866591 |
| relationship between gastric inflammatory response and symptoms in patients infected with helicobacter pylori. | the relationship between the histologic severity of gastritis and associated symptoms was examined in 19 adult patients infected with helicobacter pylori. at the time of gastrointestinal endoscopy, symptoms of dyspepsia were assessed by means of a linear analog scale. gastric inflammation was quantitated with histomorphometric techniques. symptoms such as epigastric pain, burping/belching, and nausea correlated with the degree of inflammation. these positive correlations suggest that the severit ... | 1991 | 1866592 |
| gastric spiral bacilli in captive cheetahs. | two kinds of gastric spiral bacilli were identified in the stomachs of captive cheetahs with naturally occurring gastritis. one type was morphologically similar to 'gastrospirillum hominis'. this organism could not be cultured in vitro. some of these bacteria had superficial helical filaments, and others did not. the other type was morphologically, biochemically, and bacteriologically similar to helicobacter pylori. this organism is most likely a new species of helicobacter. one or both of these ... | 1991 | 1866593 |
| genomic variation in helicobacter pylori: application to identification of strains. | dna digest analysis, ribopatterns, and plasmid profiling were used to determine genomic variation in 55 strains of helicobacter pylori from patients with gastritis in the usa, peru, australia, and the u.k. haeiii-ribopatterns and total dna digest patterns showed a high degree of heterogeneity, with at least 33 different genomic types among strains, including some sequential isolates. plasmids, present in 51% of strains, were less useful as epidemiologic markers. investigation of 14 multiple isol ... | 1991 | 1866594 |
| helicobacter pylori and progressive gastric pathology that predisposes to gastric cancer. | evidence is presented suggesting that infection by helicobacter pylori triggers and continuously contributes to the pathophysiology of progressive gastric changes that can ultimately lead to gastric cancer. in peru, especially in population groups of low socioeconomic status, infection by h. pylori begins earlier in life and is more prevalent and persistent than in developed countries. the infection produces a destructive lesion of the mucinous surface epithelium which probably enables other agg ... | 1991 | 1866595 |
| characterization of the morphologic conversion of helicobacter pylori from bacillary to coccoid forms. | growth studies of helicobacter pylori were performed involving analysis of the bacterium and its microenvironment, to lend insight into the factors responsible for the morphologic conversion phenomenon. h. pylori converted from bacillary to coccoid forms in broth culture after incubation for 5 days under microaerobic conditions with agitation. this morphologic conversion was paralleled by a dramatic decrease in colony-forming units per milliliter (cfu/ml) and a significant endogenous increase in ... | 1991 | 1866596 |
| factors affecting gastric mucosal hydrophobicity in man. | contact angle measurements in animal studies have demonstrated that gastric mucosa has a relatively hydrophobic surface. we have developed and validated a technique for the measurement of this property on human endoscopic biopsy specimens. mean contact angle of the gastric body (70 degrees) and antrum (70 degrees) was higher than the duodenal bulb (62 degrees; p less than 0.01) and distal duodenum (50 degrees; p less than 0.001). subjects with duodenal ulcer and gastric ulcer had a lower contact ... | 1991 | 1866597 |
| helicobacter pylori stimulates pepsin secretion from isolated rabbit gastric glands. | in man, type-b gastritis caused by helicobacter pylori has been associated with both increased serum pepsinogen in the presence of hypochlorhydria and increased levels of gastric pepsin. we investigated the effect of h. pylori on pepsinogen secretion in vitro and found that a sonicated preparation of h. pylori increased pepsinogen secretion from isolated rabbit gastric glands. this increase was significant after 5 min (p = 0.001), and maximum secretion was obtained after 30 min of incubation. th ... | 1991 | 1866598 |
| [ciprofloxacin-omeprazole combination therapy for eradication of helicobacter pylori]. | 20 h. pylori-positive patients with gastric or duodenal ulcer disease (n = 16, one with proof of gastric cancer obtained by histology) or severe non-ulcer dyspepsia (n = 4) were entered in a pilot study to examine the effect of a combination of omeprazole (40 mg) before breakfast and ciprofloxacin (2 x 500 mg) 1 hour after meals for 1 week to treat helicobacter pylori (hp). the eradication rate was 15% (3 out of 20 patients) 4 weeks after therapy. ulcer healing occurred in 2 of 3 patients having ... | 1991 | 1866970 |
| helicobacter pylori and peptic ulcer disease. | | 1991 | 1870644 |
| helicobacter pylori in seventh-day adventists? | | 1991 | 1872679 |
| presence of spiral bacteria ("gastrospirillum hominis") in the gastric mucosa. | | 1991 | 1874254 |
| duodenal ulcer relapse after eradication of helicobacter pylori. | thirty-six patients with healed duodenal ulcers, 27 infected with helicobacter pylori and nine uninfected, were followed for up to 12 months to determine the rate of ulcer relapse. eight patients withdrew over the follow up period. at one year, 15 of 20 (75%) infected patients and one of eight (13%) uninfected patients had relapsed, p less than 0.05. eradication of h pylori favourably influences the natural history of duodenal ulcer recurrence. significant patient morbidity may be prevented by u ... | 1991 | 1876335 |
| [integration of macro and micro syndrome differentiation]. | | 1991 | 1879036 |
| some practical advice concerning helicobacter pylori. | | 1991 | 1879120 |
| advances in etiology, diagnosis, and treatment of gastric disorders. | | 1991 | 1879121 |
| helicobacter pylori in barrett's oesophagus. gruppo operativo per lo studio delle precancerosi esofagee (gospe)--precancerous lesions of the oesophagus task force, italy. | | 1991 | 1879820 |
| purification and characterization of helicobacter mustelae urease. | helicobacter mustelae is a urease-rich bacterium associated with gastritis in ferrets. the ureases of h. mustelae and helicobacter pylori, a bacterium implicated in human gastritis, share many characteristics. helicobacter sp. ureases appear to be unique among bacterial enzymes in exhibiting submillimolar km values and in being composed of two subunits. | 1991 | 1879950 |
| factors influencing the epidemiology of helicobacter pylori infection in children. | the epidemiology of helicobacter pylori infection was studied in 245 healthy children (between 3 and 20 years of age) who presented for day surgery at arkansas children's hospital. h pylori infection was identified serologically using an enzyme-linked immunosorbent assay to detect the presence of igg against the high molecular weight, cell-associated antigens of h pylori. demographic information collected included age, gender, race, family income, type of housing, location of housing, water supp ... | 1991 | 1881740 |
| [the experimental and clinical effect of ciprofloxacin on the microflora of the gastrointestinal tract]. | the study of the influence of cyprofloxacin on the microflora of the gastrointestinal tract has been made under experimental and clinical conditions. as revealed in this study, cyprofloxacin produces a corrective effect on the intestinal microflora; the action of this preparation, in contrast to that of other antimicrobial preparations, is retained for a long time. in patients having duodenal ulcer with bacteriosis caused by campylobacter pylori and with intestinal dysbacteriosis the combination ... | 1991 | 1882618 |
| helicobacter pylori-negative duodenal ulcer. | most patients with chronic duodenal ulcer (du) craters have gastritis associated with helicobacter pylori (hp), now thought to be the major cause of du. a smaller proportion of du patients have no detectable hp. in this study, we examined the frequency and causes of hp-negative duodenal ulcers. in 302 consecutive patients with endoscopic diagnosis of duodenal ulcer, 284 (94%) were found to have associated hp gastritis, whereas 18 (6%) were hp-negative on histology, culture, and urease test. the ... | 1991 | 1882793 |
| simple noninvasive method to test efficacy of drugs in the eradication of helicobacter pylori infection: the example of combined bismuth subsalicylate and nitrofurantoin. | eradication of helicobacter pylori infections has proved to be difficult. there is a need both for improved therapies and for ways to rapidly identify therapies that show sufficient promise to be worth pursuing. the objectives of this study were to evaluate the value of a therapeutic regimen of a bismuth salt plus nitrofurantoin for eradication of infection by h. pylori and to determine the validity/utility of the urea breath test in monitoring the progress of a clinical trial. we used an 80% er ... | 1991 | 1882794 |
| omeprazole therapy modifies the gastric localization of helicobacter pylori. | | 1991 | 1882813 |
| a simplified diagnostic approach to helicobacter pylori infection--is it adequate? | | 1991 | 1882814 |
| [helicobacter pylori: a new pathogen to be considered in infancy]. | a prospective study in 11 consecutive children with gastroduodenal disease is presented. endoscopic study and gastric biopsies were performed for histologic and bacteriologic research of h. pylori. endoscopic studies in 7 of the patients showed lesions of antritis that were assessed by histopathologic study. h. pylori was isolated in 4 of them. the presence of h. pylori in the stomach of children with chronic gastritis is confirmed. it is remarked the importance of gastric biopsy, at least when ... | 1991 | 1883112 |
| helicobacter pylori infection and duodenal ulcer. | | 1991 | 1884072 |
| peptic ulcer in new zealand. | | 1991 | 1884951 |
| diagnostic approaches and treatment of peptic ulcer at chulalongkorn university hospital, bangkok. | gastroscopy is the main investigative tool in the diagnosis of peptic ulcers in thailand. in spite of its potential diagnostic value, endoscopic biopsy for histologic diagnosis is reserved only for suspected malignant gastric ulcers. regarding treatment, duodenal ulcers can be treated satisfactorily with either low-dose antacid or one of the various h2-blockers, while gastric ulcers show a fairly good healing response to site-protective agents. further trials using potent acid inhibitors, antibi ... | 1991 | 1884956 |
| neutrophil activation by helicobacter pylori. | helicobacter pylori infection of the stomach is accompanied by a persistent polymorphonuclear leukocyte (pmnl) infiltrate of the mucosa. the aim of this work was to study the activation of human pmnl by substances produced by h pylori. filtered h pylori conditioned media stimulated a significant pmnl oxidative burst (p less than 0.002). this was equal to 26% of the maximal response stimulated by the pmnl chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (fmlp, 1 mumol/l). the response ... | 1991 | 1885065 |
| effect of inhibition of helicobacter pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects. | the mechanism of the hypergastrinaemia associated with helicobacter pylori infection is unknown. it may be an effect of the ammonia produced by the bacterium near the antral epithelial surface. we have examined the effect on serum gastrin of inhibiting h pylori urease activity with acetohydroxamic acid in six duodenal ulcer patients. on day 1 the fasted patients received placebo tablets at 8 am, a peptide meal at 10 am, and a 14c urea breath test at 11.30 am. the next day 750 mg acetohydroxamic ... | 1991 | 1885067 |
| macromolecular structure and aggregation states of helicobacter pylori urease. | urease purified from helicobacter pylori by differential ultracentrifugation and fast pressure liquid chromatography was composed of subunits with apparent molecular weights (mrs) of 66,000 and 30,000. electron microscopy of this purified material demonstrated that it formed disc-shaped macromolecular aggregates that were approximately 13 nm in diameter and 3 nm thick. images of both negatively stained and shadowed preparations indicated that the discs tended to stack to form pairs and then thes ... | 1991 | 1885543 |
| identification, purification, and characterization of major antigenic proteins of campylobacter jejuni. | evidence from developing countries and volunteer studies indicates that immunity to campylobacter jejuni and campylobacter coli may be acquired, but the antigenic basis for this protection is poorly defined. we have purified to homogeneity four proteins with molecular weights of 28,000 (peb1), 29,000 (peb2), 30,000 (peb3), and 31,000 (peb4) from epidemic c. jejuni strain 81-176 using acid extraction and sequential ion-exchange, hydrophobic interaction, and gel filtration chromatography. the rela ... | 1991 | 1885571 |
| seropositivity to helicobacter pylori: lack of association with length of hospitalization. | to examine the possibility of nosocomial spread of helicobacter pylori, a serosurvey (n = 238) was conducted at perry point department of veterans affairs medical center, an institution providing both acute and chronic care. we hypothesized that if significant nosocomial transmission was occurring, seropositivity (as measured by enzyme-linked immunosorbent assay [elisa]) would correlate with length of stay in the facility. whether treated as a continuous or dichotomous variable, the elisa result ... | 1991 | 1885734 |
| helicobacter pylori gastritis mimicking gastric carcinoma at ct evaluation. | the abdominal computed tomographic (ct) scans from 61 patients with biopsy-proved helicobacter (formerly campylobacter) pylori gastritis were retrospectively reviewed. the ct scans were interpreted on the basis of the original report of the findings at ct examination and without knowledge of the results of biopsy. of 19 patients (31%) with gastric abnormalities at ct, 14 (74%) had inflammatory changes initially reported as suspicious for gastric malignancy; malignancy was entertained as the prim ... | 1991 | 1888360 |
| [helicobacter pylori gastritis: a new infectious disease. reflections from a personal experience]. | to determine the relationship of microscopic chronic antral gastritis to helicobacter pylori, 69 consecutive patients were studied. in a prospective longitudinal study, at least 2 successive gastroscopies with antral biopsies were performed (177 investigations on the whole). sixty six of the 69 patients were treated with various therapeutic regimens i.e. antiulcer drugs and/or antibiotics. the type and intensity of inflammation (as based on whole inflammatory infiltrate density, polymorphonuclea ... | 1991 | 1888390 |
| eradication of helicobacter pylori abolishes 24-hour hypergastrinaemia: a prospective study in healthy subjects. | in a prospective study, eight young healthy subjects (five with an active h. pylori infection in the antral mucosa) were treated with a course of tripotassium dicitrato bismuthate, amoxycillin and metronidazole. the triple therapy eradicated infection when assessed 20-24 weeks later by antral biopsy (urease, histology, and 13c urea breath test [4 out of 5 subjects]). twenty-four hour intragastric acidity and plasma gastrin concentration were measured before treatment, and 4-6 weeks and 20-24 wee ... | 1991 | 1888827 |
| omeprazole and helicobacter pylori: temporary suppression rather than true eradication. | twenty-four helicobacter pylori (h. pylori)-positive patients were treated for 28 days with either 20 mg omeprazole o.m. (n = 12) or 40 mg omeprazole o.m. (n = 12). clearance (absence of h. pylori at the end of or shortly after treatment) and eradication (absence of h. pylori 1 month after cessation of treatment) were assessed using the 14c-urea breath test. observed clearance and eradication were: 20 mg omeprazole 3/12 and 0/12; 40 mg omeprazole 6/12 and 1/12 respectively. the effect on h. pylo ... | 1991 | 1888829 |
| helicobacter pylori: review of research findings. | helicobacter pylori attracted widespread interest from gastroenterologists because of its potential aetiologic role in disorders of the upper gastrointestinal tract. based on extensive microbiological studies, campylobacter pylori was renamed helicobacter pylori, and the organism represents a new genus of bacteria. it is generally accepted that h. pylori causes chronic, non-specific gastritis (type b gastritis). the inflammatory response occurs even though the bacterium does not penetrate the ga ... | 1991 | 1888832 |
| non-ulcer dyspepsia: myths and realities. | dyspepsia can be defined as the presence of upper abdominal pain or discomfort; other symptoms referable to the proximal gastrointestinal tract, such as nausea, early satiety, and bloating, may also be present. symptoms may or may not be meal related. to be termed chronic, dyspepsia should have been present for three months or longer. over half the patients who present with chronic dyspepsia have no evidence of peptic ulceration, other focal lesions, or systemic disease and are diagnosed as havi ... | 1991 | 1888833 |
| effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. | the effects of age on basal, meal-stimulated, and human gastrin-17-stimulated gastric acid secretion rates and serum pepsinogen concentrations were evaluated in 41 healthy men and women. older subjects (ages 44-71 years; mean, 57 years) had higher mean basal, meal-stimulated, and gastrin-17-stimulated acid secretory rates and basal serum pepsinogen i and ii concentrations than younger subjects (ages 23-42 years; mean, 33 years). age-related differences in acid secretion were especially prominent ... | 1991 | 1889722 |
| sampling efficiency in the diagnosis of helicobacter pylori infection and chronic active gastritis. | the methods and sampling procedures used in the diagnosis of helicobacter pylori infection and chronic active gastritis were evaluated. five biopsy specimens for bacteriological cultivation and three specimens for histological examination were obtained endoscopically from a defined area of the gastric antral mucosae of 83 patients. an increase in the number of biopsy specimens for cultivation from one to five revealed only one more h. pylori-infected patient. h. pylori was isolated from 31 of 83 ... | 1991 | 1890167 |
| detection of helicobacter pylori by using the polymerase chain reaction. | a 1.9-kb cloned fragment of chromosomal dna randomly selected from a helicobacter pylori cloned library was evaluated as a potential probe. the probe detected 19 of 19 h. pylori strains and yielded a specificity of 98.7% when tested against 306 other bacterial strains representing 32 different species. false-positive results with non-h. pylori strains were due to the presence of contaminating vector sequences. a polymerase chain reaction (pcr) assay was developed by using 20-base oligonucleotide ... | 1991 | 1890169 |
| egg yolk emulsion agar, a new medium for the cultivation of helicobacter pylori. | we developed a new agar, egg yolk emulsion (eye) agar, for cultivation of helicobacter pylori. eye agar contains columbia agar base (oxoid), 10% eye (oxoid), 1% isovitalex (bbl), and 40 mg of triphenyleteraxolium chloride (sigma) per liter. we compared eye agar with the following agars: (i) brain heart infusion agar-7% horse blood-1% isovitalex (gdw agar; c. s. goodwin, e. d. blincow, j. r. warren, t. e. waters, c. r. sanderson, and l. easton, j. clin. pathol. 38:1127-1131, 1985), (ii) brain hea ... | 1991 | 1890184 |
| inhibition of urease activity but not growth of helicobacter pylori by acetohydroxamic acid. | the in vitro effects of acetohydroxamic acid (aha), a potent urease inhibitor, were studied to determine the effect on the urease activity and growth of 38 strains of helicobacter pylori. aha in concentrations of 50-1000 mg/l had a noticeably reversible inhibitory effect on the urease activity of the organism but no effect on growth. | 1991 | 1890207 |
| detection of helicobacter pylori carriers by discriminant analysis of urea and ph levels in gastric juices. | an alternative approach to the problems inherent in current methods for detecting helicobacter pylori carriers--that of being generally time-consuming, expensive, and not sufficiently sensitive--was devised by using the urea concentration and ph levels of gastric juices. a linear discriminant analysis of these variables, measured in 54 patients submitted to digestive endoscopy for gastritis, provided a mathematical formula for assigning the subjects (previously classified by other standard metho ... | 1991 | 1890208 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 41-1991. a 76-year-old man with recurrent gastrointestinal bleeding. | | 1991 | 1891010 |
| helicobacter pylori infection and the risk of gastric carcinoma. | infection with helicobacter pylori has been linked with chronic atrophic gastritis, an inflammatory precursor of gastric adenocarcinoma. in a nested case-control study, we explored whether h. pylori infection increases the risk of gastric carcinoma. | 1991 | 1891020 |
| helicobacter pylori infection and gastric carcinoma among japanese americans in hawaii. | helicobacter pylori are gram-negative spiral bacteria that are associated with chronic gastritis, a known precursor of gastric carcinoma. persons at high risk for gastric carcinoma have been shown to have a high prevalence of h. pylori infection. | 1991 | 1891021 |
| is gastric carcinoma an infectious disease? | | 1991 | 1891027 |
| [campylobacter (helicobacter) pylori in chronic erosive gastritis, duodenitis and gastroduodenitis]. | the presence and degree of manifestation of campylobacter (helicobacter) pylori in gastroduodenal mucosa were studied in 100 patients (56 men, mean age 51.4 years, and 44 women, mean age 46.5 years) with endoscopically proved chronic erosive gastritis (52 patients), erosive duodenitis (36 patients) and erosive gastroduodenitis (12 patients). the examinations revealed the presence of campylobacter (helicobacter) pylori in mean 77% of the patients with erosive gastritis, duodenitis and gastroduode ... | 1991 | 1891906 |
| mucosal humoral immune response to helicobacter pylori in patients with duodenitis. | the humoral immune response to helicobacter pylori infection in the duodenum has been investigated by short-term in vitro culture, elisa, and immunoblotting techniques. h. pylori iga secretion by duodenal bulb biopsies was significantly increased (p less than 0.001) in patients with duodenitis. the iga response to h. pylori in patients with duodenitis was restricted to the first part of the duodenum; second part duodenal biopsies secreting significantly (p less than 0.001) less iga during cultur ... | 1991 | 1893811 |
| neutrophil chemotaxis in gastric mucosa. a signal-to-response comparison. | this prospective study compares levels of neutrophil chemotactic activity (nca) in gastric juice to the neutrophil count in gastric biopsies. sixty-three male patients enrolled in the study and had antral biopsies following collection of gastric juice during esophagogastroduodenoscopy. biopsies were examined for the magnitude of gastritis, tissue pmn count, and presence of helicobacter pylori. secretions were assayed for neutrophil chemotactic activity. results show an increase in nca and in tis ... | 1991 | 1893813 |
| inhibition of acid secretion from parietal cells by non-human-infecting helicobacter species: a factor in colonization of gastric mucosa? | helicobacter pylori has been shown to produce a protein that inhibits acid secretion from parietal cells. we have examined other non-human-infecting helicobacter species for this property by measuring the uptake of [14c]aminopyrine into rabbit parietal cells as an indirect assessment of acid secretion. helicobacter felis and an isolate from a rhesus monkey were shown to inhibit acid secretion. isolates of helicobacter mustelae gave variable responses. whole bacteria and cell-free sonicates impai ... | 1991 | 1894369 |
| helicobacter pylori infection in uraemic patients. | | 1991 | 1896109 |
| is gastroduodenitis a cause of chronic dyspepsia? | the role of helicobacter pylori infection in causing chronic dyspepsia is in need of further clarification. more well-designed prospective studies are necessary to ascertain whether and to what extent h. pylori-related chronic inflammation in the stomach and the duodenum causes dyspeptic symptoms; whether and to what extent there is a symptom cluster characteristic for h. pylori-related gastroduodenitis; whether and to what extent h. pylori infection is demonstrable in the chronic dyspeptic popu ... | 1991 | 1896828 |
| drug treatment of functional dyspepsia. | the therapeutic principles that have been applied to patients with peptic ulceration have often also been applied to those with functional dyspepsia, who by definition have no evidence of a structural or biochemical explanation for their symptoms. treatments offered have included prokinetic drugs, anticholinergics, antacids, h2-receptor antagonists, selective muscarinic m1-receptor blockers, sucralfate, bismuth, antibiotics, and even surgery. the large range of therapies prescribed reflects the ... | 1991 | 1896830 |
| duodenal ulcer: the villain unmasked? | | 1991 | 1898444 |
| helicobacter pylori and duodenal ulceration. | | 1991 | 1899674 |
| blood lymphocyte proliferation, cytokine secretion and appearance of t cells with activation surface markers in cultures with helicobacter pylori. comparison of the responses of subjects with and without antibodies to h. pylori. | a whole inactivated h. pylori bacterium preparation was found to stimulate blood mononuclear cells from both antibody-positive and antibody-negative subjects, but the antibody-positive subjects tended to have lower proliferation responses. the present study was designed to characterize t cell activation further by measuring several components of the response. eighty-seven subjects (80 dyspeptic patients and seven healthy persons from the laboratory staff) with or without antibodies to h. pylori ... | 1991 | 1900743 |
| glycolipid receptor binding specificity of exoenzyme s from pseudomonas aeruginosa. | by use of the tlc overlay procedure we have shown that exoenzyme s extracted from cultures of pseudomonas aeruginosa specifically binds to the glycolipids asialogm1, asialogm2 and to a lesser extent lactosyl ceramide. more significantly, strong binding was also observed to the glycerolipid receptor we have detected for helicobacter pylori (lancet ii, 238-241.1989). exoenzyme s can be extracted in a toxic and nontoxic form. toxicity correlated with ability to bind the h. pylori receptor. this spe ... | 1991 | 1902668 |
| one-minute endoscopy room test for helicobacter pylori: interference with 2% glutaraldehyde. | | 1991 | 1907092 |
| helicobacter pylori and chronic active inflammation of the duodenum and stomach in duodenal ulcer patients treated with ranitidine, misoprostol, or an acid-neutralizing agent. | biopsy specimens from the stomach and duodenum of 45 duodenal ulcer patients treated with ranitidine, misoprostol, or an antacid were examined. during 4 weeks of treatment the duodenal ulcer healed in 31 patients. the treatment regimens showed no significant effect on the amount of helicobacter-like structures (hls) or the presence of active inflammation, either in the stomach or in the duodenum. all patients had chronic active antral gastritis before and after treatment. hls were found histolog ... | 1991 | 1908115 |
| [helicobacter pylori and duodenal ulcer treated with omeprazole]. | | 1991 | 1910925 |
| helicobacter pylori: its epidemiology and its role in duodenal ulcer disease. | | 1991 | 1912414 |
| helicobacter pylori: causal agent in peptic ulcer. microbiological aspects. | | 1991 | 1912415 |
| virulence and pathogenicity of helicobacter pylori. | h. pylori is a highly virulent organism as evidenced by its low infective dose and widespread high prevalence in human populations. its virulence is achieved through its ability to survive in a moist environment and its massive urease production which allows it to survive in the acidic gastric juice long enough to colonize the gastric mucus. gastric colonization is facilitated by cell wall associated lectins which permit the bacterium to bind to gastric mucus and the gastric epithelial cell. onc ... | 1991 | 1912416 |
| helicobacter pylori and peptic ulceration: histopathological aspects. | | 1991 | 1912417 |