| the brain-penetrating, orally bioavailable, ghrelin receptor agonist hm01 ameliorates motion-induced emesis in suncus murinus (house musk shrew). | hm01, a novel, orally bioavailable, brain-penetrating agonist of ghrelin receptors, ameliorates emesis in suncus murinus. this study compared hm01's activity against motion sickness with that of the less brain-penetrating ghrelin receptor agonist, hm02. | 2020 | 31722444 |
| molecular identification, characterization, and structure analysis of house musk shrew (suncus murinus) leptin. | house musk shrew (suncus murinus), a small experimental animal with low body fat, may be a possible model for human lipodystrophy. leptin is an adipocyte-derived hormone thought to have an important role in the pathophysiology of lipodystrophy. the objectives of this study were to clarify the structure and distribution of suncus leptin. | 2019 | 31453164 |
| methicillin-resistant staphylococcus aureus among urban rodents, house shrews, and patients in guangzhou, southern china. | the transmission of methicillin-resistant staphylococcus aureus (mrsa) between humans and animals has been identified in a number of countries. in this study, mrsa in urban rodents and shrews in a community was investigated. further, comparisons of mrsa isolates from rodents, shrews, and humans were conducted to evaluate the relationships of these isolates from different origins. | 2019 | 31345215 |
| generation and characterization of suncus murinus intestinal organoid: a useful tool for studying motilin secretion. | motilin, a 22-amino-acid peptide produced in the upper small intestine, induces strong gastric contraction in fasted state. in many rodents, motilin and its cognate receptors exist as pseudogenes, which has delayed motilin research in the past decades. recently, the house musk shrew (suncus murinus) was developed as a useful model for studying motilin and gastrointestinal motility. however, due to a lack of motilin-producing cell lines and difficulties in culturing small intestinal cells, the re ... | 2019 | 31293061 |
| molecular cloning and analysis of suncus murinus group iia secretary phospholipase a2 expression. | the intestinal epithelial monolayer forms a mucosal barrier between the gut microbes and the host tissue. the mucosal barrier is composed of mucins and antimicrobial peptides and proteins (amps). several animal studies have reported that paneth cells, which occupy the base of intestinal crypts, play an important role in the intestinal innate immunity by producing amps, such as lysozyme, reg3 lectins, α-defensins, and group iia secretory phospholipase a2 (giia spla2). the house musk shrew (suncus ... | 2019 | 31278953 |
| comparison of the gut microbiotas of laboratory and wild asian house shrews (suncus murinus) based on cloned 16s rrna sequences. | the asian house shrew, suncus murinus, is an insectivore (eulipotyphla, mammalia) and an important laboratory animal for life-science studies. the gastrointestinal tract of suncus is simple: the length of the entire intestine is very short relative to body size, the large intestine is quite short, and there are no fermentative chambers such as the forestomach or cecum. these features imply that suncus has a different nutritional physiology from those of humans and mice, but little is known about ... | 2019 | 31217361 |
| detection of hepatitis b virus-like nucleotide sequences in liver samples from murine rodents and asian house shrews. | in recent years, hepatitis b virus (hbv) has been detected in some species of animals. in this study, we found hbv-like nucleotide sequences in murine rodents and asian house shrews (suncus murinus) collected in china. a total of 801 animals were trapped. we found that 0.48% (3/624) of the murine rodents and 1.69% (3/177) of asian house shrews were positive for hbv-like dna. detection of hbv-like dna in brown rats (rattus norvegicus), rice-field rat (rattus losea), and asian house shrews indicat ... | 2019 | 31216240 |
| use of a microelectrode array to record extracellular pacemaker potentials from the gastrointestinal tracts of the icr mouse and house musk shrew (suncus murinus). | the rhythmic contraction and relaxation of smooth muscles in the gastrointestinal (gi) tract is governed by pacemaker electrical potentials, also termed slow waves, which are calcium currents generated by interstitial cells of cajal (iccs). malfunction of pacemaker rhythms contributes to a number of clinically challenging gastrointestinal motility disorders. | 2019 | 31125825 |
| gabaergic and glutamatergic neurons in the brain regulate phase ii of migrating motor contractions in the suncus murinus. | gastric contractions exhibit characteristic motor patterns in the fasted state, known as migrating motor contractions (mmc). mmc consist of three periodically repeated phases (phase i, ii and iii) and are known to be regulated by hormones and the autonomic and enteric nervous systems. however, the central regulation of gastric contractions in the fasted state is not completely understood. here, we have examined the central effects of motilin, ghrelin, γ-aminobutyric acid (gaba) and l-glutamate s ... | 2018 | 30787212 |
| novel hepacivirus in asian house shrew, china. | | 2019 | 30701456 |
| identification and characterization of an antimicrobial peptide, lysozyme, from suncus murinus. | lysozyme is one of the most prominent antimicrobial peptides and has been identified from many mammalian species. however, this enzyme has not been studied in the order insectivora, which includes the most primitive placental mammals. here, we done the lysozyme cdna from suncus murinus (referred to as suncus, its laboratory name) and compare the predicted amino acid sequence to those from other mammalian species. quantitative pcr analysis revealed a relatively higher expression of this gene in t ... | 2019 | 30680460 |
| the prevalence and genomic characteristics of hepatitis e virus in murine rodents and house shrews from several regions in china. | urban rodents and house shrews are closely correlated in terms of location with humans and can transmit many pathogens to them. hepatitis e has been confirmed to be a zoonotic disease. however, the zoonotic potential of rat hev is still unclear. the aim of this study was to determine the prevalence and genomic characteristics of hepatitis e virus (hev) in rodents and house shrews. | 2018 | 30577796 |
| a molecular epidemiological investigation of carriage of the adeno-associated virus in murine rodents and house shrews in china. | to investigate the prevalence of the adeno-associated virus (aav) in murine rodents and house shrews in 4 provinces of china. | 2018 | 30404084 |
| characteristics of muscle fiber-type distribution in moles. | moles are a strictly fossorial soricomorpha species and possess a suite of specialized adaptations to subterranean life. however, the contractile function of skeletal muscles in moles remains unclear. we compared muscle fiber-type distribution in two mole species (the large japanese mole and lesser japanese mole) with that in four other soricomorpha species that are semi-fossorial, terrestrial, or semi-aquatic (the japanese shrew-mole, house shrew, japanese white-toothed shrew, and japanese wate ... | 2019 | 30376699 |
| small-scale spatial analysis of intermediate and definitive hosts of angiostrongylus cantonensis. | angiostrongyliasis is a food-borne parasitic zoonosis. human infection is caused by infection with the third-stage larvae of angiostrongylus cantonensis. the life cycle of a. cantonensis involves rodents as definitive hosts and molluscs as intermediate hosts. this study aims to investigate on the infection status and characteristics of spatial distribution of these hosts, which are key components in the strategy for the prevention and control of angiostrongyliasis. | 2018 | 30318019 |
| corrigendum: anti-emetic action of the brain-penetrating new ghrelin agonist, hm01, alone and in combination with the 5-ht3 antagonist, palonosetron and with the nk1 antagonist, netupitant, against cisplatin- and motion-induced emesis in suncus murinus (house musk shrew). | [this corrects the article doi: 10.3389/fphar.2018.00869.]. | 2018 | 30310382 |
| the distribution of nerves supplying the testis, epididymis and accessory sex glands of suncus murinus. | chronic testicular pain remains an important challenge for urologists. investigation of the innervation of male gonads thus becomes essential for deepening our understanding of their regulatory roles in male reproductive physiology and pathophysiology. studies of testicular innervation are mainly limited to the intratesticular peptidergic nerves of the testis by immunohistochemical and acetylcholinesterase histochemical investigations in some animals. little is known about the detailed, overall ... | 2019 | 30206773 |
| detection and phylogenetic analysis of porcine bocaviruses carried by murine rodents and house shrews in china. | bocaparvovirus infections of humans and both wild and domestic animals have been widely reported around the world. in this study, we detected and genetically characterized porcine bocavirus (pbov) carried by murine rodents (rattus norvegicus, rattus tanezumi, and rattus losea) and house shrews (suncus murinus) in china. between may 2015 and may 2017, 496 murine rodents and 23 house shrews were captured in four chinese provinces. nested polymerase chain reaction was used to investigate the preval ... | 2019 | 30179306 |
| molecular characterization of pathogenic leptospira sp. in small mammals captured from the human leptospirosis suspected areas of selangor state, malaysia. | leptospirosis is caused by the spirochetal bacterium leptospira of which rodents are considered the most important reservoir. this study aims to determine and characterize virulent leptospira species among rodents and small mammals found in human settlements and recreational spots within the hulu langat and gombak districts of selangor, malaysia; regions that frequently report probable human leptospirosis cases. molecular analysis revealed an overall leptospira detection rate of 14.3% among the ... | 2018 | 30145261 |
| anti-emetic action of the brain-penetrating new ghrelin agonist, hm01, alone and in combination with the 5-ht3 antagonist, palonosetron and with the nk1 antagonist, netupitant, against cisplatin- and motion-induced emesis in suncus murinus (house musk shrew). | ghrelin has well-known activity to stimulate appetite and weight gain. evidence suggests that ghrelin may also have effects in reducing chemotherapy-induced emesis via growth hormone secretagogue receptors (ghs-r1a) in the brain. however, it is not known whether the stimulation of ghs-r1a has broad inhibitory anti-emetic effects. in the present studies, we used suncus murinus to investigate the potential of the new and novel orally bioavailable brain-penetrating ghs-r1a mimetic, hm01 (1-[(1s)-1- ... | 2018 | 30127745 |
| risk of maritime introduction of plague from madagascar to mayotte. | plague is a rodent-borne disease caused by yersinia pestis. most human infections are bubonic plague, as a result of being bitten by infected rodent fleas. madagascar, democratic republic of congo and peru are the three most affected countries. plague was introduced into eastern madagascar in 1898 by boat from india. it is estimated that the risk of introduction of plague from madagascar to neighboring islands is very high due to the maritime links. we conducted a study of plague reservoirs and ... | 2018 | 30075098 |
| occurrence of orientia tsutsugamushi, the etiological agent of scrub typhus in animal hosts and mite vectors in areas reporting human cases of acute encephalitis syndrome in the gorakhpur region of uttar pradesh, india. | outbreaks of acute encephalitis syndrome (aes) with high fatality and disability, are reported every year in the gorakhpur region of uttar pradesh, india, with the etiology of >60% of the cases being attributed to scrub typhus. in the present study, the prevalence of orientia tsutsugamushi, the etiological agent of scrub typhus, was investigated among animal hosts and their ectoparasitic trombiculid mites prevalent in aes-reported areas of gorakhpur. a total of 154 rodents/shrews were collected ... | 2018 | 30016222 |
| prevalence and diversity of gastrointestinal helminths in free-ranging asian house shrew (suncus murinus) in bangladesh. | asian house shrew (suncus murinus), a widely distributed small mammal in the south asian region, can carry helminths of zoonotic importance. the aim of the study was to know the prevalence and diversity of gastrointestinal (gi) helminths in free-ranging asian house shrew (s. murinus) in bangladesh. | 2018 | 29805224 |
| geographical distribution and relative risk of anjozorobe virus (thailand orthohantavirus) infection in black rats (rattus rattus) in madagascar. | hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. anjozorobe virus, a representative virus of thailand orthohantavirus (thaiv), was recently discovered from rodents in anjozorobe-angavo forest in madagascar. to assess the circulation of hantavirus at the national level, we carried out a survey of small terrestrial mammals from representative regions of the island and identified environmental factors ass ... | 2018 | 29743115 |
| lymphatic architecture of suncus murinus (house musk shrew) palatum. | the architecture of craniocervical lymphatic vessels in rodents has been examined previously. in the present study, we evaluated the distribution of collecting lymphatic vessels in the palate of suncus, which is known to retain the prototype of placental mammals and is more similar to humans in terms of jaw bone morphology when compared with rodents. three-dimensional reconstructed images of the suncus palatum revealed that the collecting lymphatic vessels were connected to each other via smalle ... | 2017 | 30234246 |
| small mammalian remains from the late holocene deposits on ishigaki and yonaguni islands, southwestern japan. | yuichiro nishioka, ryohei nakagawa, shin nunami, and satoshi hirasawa (2016) small mammalian remains were newly discovered from the late quaternary sediments of the yaeyama region (ishigaki and yonaguni islands) in the southwestern-most part of japan. we examined these materials based on taxonomical and chronological approaches, in order to reconstruct the past fauna in this region. accelerator mass spectrometry radiocarbon dating indicates that the mammalian assemblages from ishigaki and yonagu ... | 2016 | 31966150 |
| mastication in the musk shrew, suncus murinus (mammalia, soricidae). | high-speed cinematography shows that suncus murinus (crocidurinae) masticates fast (mean 5.5, 5-10 masticatory cycles per sec). their grasping behavior is not stereotyped. the unilateral mandibular movements combine vertical, anteroposterior, and lateral displacements; and any masticatory sequence may include crushing, repositioning, shearing, and grinding components. size and consistency of food influence the duration of individual chewing cycles. as food is transferred to the new working side, ... | 1986 | 29940708 |
| detection of virus-related sequences associated with potential etiologies of hepatitis in liver tissue samples from rats, mice, shrews, and bats. | hepatitis is a major global health concern. however, the etiology of 10-20% hepatitis cases remains unclear. some hepatitis-associated viruses, like the hepatitis e virus, are zoonotic pathogens. rats, shrews, and bats are reservoirs for many zoonotic pathogens. therefore, understanding the virome in the liver of these animals is important for the investigation of the etiologies of hepatitis and monitoring the emerging zoonotic viruses. in this study, viral metagenomics and pcr methods were used ... | 2021 | 34177835 |