| chloroquine-resistant plasmodium falciparum malaria in kenya. | a case of chloroquine-resistant plasmodium falciparum malaria in a non-immune male is reported. primary attack came 19 days after return to a non-malarious country from a visit to kenya. recrudescences occurred three times with intervals of 30 to 33 days after standard chloroquine treatment. the who extended field test for sensitivity of falciparum malaria to chloroquine was followed by recrudescence 31 days later. treatment with fansidar terminated the infection. if continuous treatment of the ... | 1979 | 382468 |
| a method for large-volume cultivation of malaria parasites based on the principle of the trager-jensen culture method. | | 1979 | 382473 |
| liposomes in the chemotherapy of experimental murine malaria. | | 1979 | 382476 |
| new experimental antimalarial drugs. | | 1979 | 382797 |
| [two new cases of autochtonous malaria in the parisian area showing two different modes of contamination]. | | 1978 | 383308 |
| plasmodium berghei: uptake of clindamycin and its metabolites by mouse erythrocytes with clindamycin-sensitive and clindamycin-resistant parasites. | | 1979 | 383487 |
| plasmodium falciparum: loss of knobs on the infected erythrocyte surface after long-term cultivation. | | 1979 | 383488 |
| [serodiagnosis of malaria. plasmodium berghei and p. falciparum as antigen for the indirect immune of fluorescence test (author's transl)]. | serum samples of malaria patients were investigated by the iift with p. berghei antigen (from mice) and p. falciparum antigen (from in vitro cultures). both antigens were useful principally and produced approximately identical results. p. falciparum antigen produced mostly higher titres than p. berghei antigen. in cases of lack of homologous malaria antigen it can be suitable to use an antibody-free p. berghei antigen for the iift, especially in cases of epidemiological studies. for the individu ... | 1979 | 383607 |
| observations on malaria in an industrial area of chotonagpur. | | 1978 | 383847 |
| synchronization of plasmodium falciparum erythrocytic stages in culture. | synchronous development of the erythrocytic stages of a human malaria parasite, plasmodium falciparum, in culture was accomplished by suspending cultured parasites in 5% d-sorbitol and subsequent reintroduction into culture. immediately after sorbitol treatment, cultures consisted mainly of single and multiple ring-form infections. at the same time, varying degrees of lysis of erythrocytes infected with the more mature stages of the parasite was evident. approximately 95% of the parasites were i ... | 1979 | 383936 |
| plasmodium falciparum in culture: improved continuous flow method. | a new design of flow vessel provides a method for continuous culture of p. falciparum in a settled layer of human erythrocytes with a slow flow of culture medium over them. the parasitemia is kept fluctuating from approximately 1%, just after addition of fresh erythrocytes, to approximately 10%, 2 or 3 days later. each vessel provides each week 3 harvests, each containing approximately 0.6--1 x 10(9) parasites. | 1979 | 383969 |
| observations on gametogenesis in plasmodium falciparum from continuous culture. | gametocytes of plasmodium falciparum were produced in continuous cultures but eventually declined in numbers after 3--4 months in vitro. their development progressed in a consistent pattern, from small rounded, through triangular, to ellipsoidal, and finally after 8 days to crescentic forms. morphologic maturity occurred at 8--9 days, but the gametocytes would not exflagellate in vitro, even after 14--18 days of development. thus, current culture methods cannot produce a continuous supply of fun ... | 1979 | 383970 |
| [aspects of malaria epidemiology in the people's democratic republic of yemen]. | | 1979 | 384190 |
| [pressing problems of malaria prevention in the ussr]. | | 1979 | 384191 |
| [tertiarty malaria with a long incubation period caused by a plasmodium vivax strain in a turkish woman]. | | 1979 | 384272 |
| [autochtone malaria]. | | 1979 | 384362 |
| the effect of prednisolone on red cell survival in patients with falciparum malaria. | radioisotope red-cell survival studies were carried out in 20 patients with falciparum malaria following quinine therapy. the mean parasite clearance time of the patients receiving quinine sulfate was 49 hours and those of the patients receiving quinine sulfate and prednisolone was 46 hours. the red-cell survival was correlated with the initial hematocrit level in both groups but the daily dose of 40 mg prednisolone did not mitigate the red cell survival. | 1979 | 384543 |
| treatment of falciparum malaria in thai children. | | 1979 | 384544 |
| in vivo and in vitro studies of quinine sensitivity of plasmodium falciparum in thailand. | forty-four patients with falciparum malaria were studied. nine patients were given quinine orally at a daily dose of 1.5 gm base for a period of 14 days. the mean parasite clearance in all 9 patients was 3.3 days, and none had recrudescence in follow-up examinations for 31 days. the in vivo study of these 9 patients showed sensitivity to quinine which correlated with the in vitro test, with concentration of quinine base 2.5-5.8 microgram/ml of blood that inhibited the maturation of plasmodium fa ... | 1979 | 384545 |
| [malaria plasmodia in the mouse. parasitization of mature and immature erythrocytes by plasmodium berghei, plasmodium yoelii and plasmodium chabaudi (author's transl)]. | plasmodium berghei parasites (strain k173) in mice with developing immunity changed to a variant type with increased resistance against antibodies and enhanced invasion of mature erythrocytes; on passages in normal mice this variant type retransformed to the normal type (kretschmar 1964). on detailed study, parasites of the variant type showed a markedly decreased predilection for polychromatophilic erythrocytes, leading to slowed multiplication during prepatency, increased invasion of mature er ... | 1979 | 384629 |
| [accidentally induced malaria]. | | 1979 | 384632 |
| the role of hemoglobins c, s, and nbalt in the inhibition of malaria parasite development in vitro. | the host cell competence of hemoglobin c (hbc)-containing erythrocytes for plasmodium falciparum was studied by in vitro culture. hbc homozygous red cells did not support the growth of the intracellular parasite. heterozygous cells, however, were competent. in addition, hbc increased the resistance of sicle cell hemoglobin (hbs) red cells when present in the double heterozygote, sc, cultured at low oxygen tension. this effect most likely resulted from the ability of hbc to enhance the sickling o ... | 1979 | 384816 |
| drug-resistant falciparum malaria among the mayongong indians in the brazilian amazon. | in april of 1977 an outbreak of falciparum malaria occurred among the mayongong indians, located at uauaris in the territory of roraima, brazil. blood specimens from 157 indians were examined for plasmodium; 62 were found to be infected. in three cases the infection was not cured with chloroquine but responded favorably to the drug combination of sulfadoxine and pyrimethamine (fansidar). | 1979 | 384818 |
| [production of interferon after infection by various doses of "plasmodium berghei" in mice (author's transl)]. | groups of mice were inoculated with either low or high intraperitoneal doses of plasmodium berghei infected erythrocytes (pie). the course of infection was observed daily by counting new pie which appeared in the red blood cells (rbc) of infected mice. at the same time, circulating interferon (if) was tested. when low doses of infecting pie were used (400 per mouse), circulating if was first detected on the 5th day after inoculation. it increased to a maximal rate, when 5% of rbc were affected. ... | 1979 | 384870 |
| plasmodium berghei--infected mice. focal glomerulonephritis in hyperimmune state. | twenty-one male swiss albino mice were injected intraperitoneally with 2 x 10(5) plasmodium berghei berghei-infected cells. twenty-four mice were used as a noninfected control group. on the tenth day after infection, three mice were killed and the remainder were treated with chloroquine phosphate (0.025% solution) given orally. the dosage was subsequently adjusted to keep the parasitemia below 5%. eighteen of the controls received the same chloroquine dosage. diffuse proliferative glomerulonephr ... | 1979 | 384958 |
| [autochthonous malaria and malarian liver. apropos of 1 case]. | report of the case of a patient, store-keeper at the roissy airport, suffering from an autochtonous primo-invasion falciparum malaria. the clinical symptoms were hectic fever and painful hepatomegalia, followed 14 days after by a typical tertian fever. all investigations being negative, a laparoscopy was carried out, which showed a black liver, and a biopsy demonstrated the malaria pigment in küpffer cells. malaria was confirmed by the study of a blood smear. this diagnostic hypothesis had not ... | 1978 | 385159 |
| the kallikrein-kinin system and its role in the hypotensive shock syndrome of animals infected with the haemorprotozoan parasites babesia plasmodium and trypanosoma. | | 1979 | 385423 |
| mechanisms of action of hyperimmune serum in mediating protective immunity to rodent malaria (plasmodium berghei). | | 1979 | 385778 |
| ultrastructural damage to the malaria parasite in the sickled cell. | the process by which malaria parasites are killed in sickled erythrocytes was studied by electron microscopy. in vitro cultures of plasmodium falciparum in sickle cell hemoglobin (hbs) homozygous (ss) and heterozygous (sa) red cells were deoxygenated for up to 6 h and fixed under anaerobic conditions. parasites in ss cells appeared to be disrupted by intrusions of needle-like deoxyhbs aggregates; disintegration of cytoplasm and membranes followed. in sa red cells, the parasites were generally no ... | 1979 | 385855 |
| freeze-fracture study of malaria sporozoites: antibody-induced changes of the pellicular membrane. | plasmodium cynomolgi, plasmodium knowlesi, and plasmodium berghei sporozoites, before and after incubation with immune serum, were studied after freeze-fracture by electron microscopy. there were evenly distributed numerous intramembranous particles (imp) on the p face of the outer membrane. the e face of the plasma membrane had fewer imp than its p face. the e face of the intermediate membrane had few imp and also linear arrays of slightly raised ridges running the length of the parasite. the p ... | 1979 | 385856 |
| malaria in australia. | | 1979 | 386057 |
| chloroquine-resistant falciparum malaria. | | 1979 | 386060 |
| [a patient with tropical malaria acquired in a south african safari park]. | | 1979 | 386142 |
| [successes of modern malariology]. | malariological situation analysis in the ussr and world over testifies to increasing malaria incidence particularly in the countries where earlier it was almost fully eradicated. malaria epidemics in these countries (posteradication epidemics) is a new phenomenon in malariology. temporary success of the global campaign of malaria eradication has led to a deadlock in malariology which during the past 10 years is being successfully overcome. achievements of modern malariology are reviewed in the a ... | 1979 | 386234 |
| antibodies to sporozoites: their frequent occurrence in individuals living in an area of hyperendemic malaria. | serum samples from 158 west africans were tested for antibodies against sporozoites, the vector stage of the malaria parasite. antibodies specific for plasmodium falciparum sporozoites were detected by means of the circumsporozoite precipitation assay and indirect immunofluorescence. more than 90 percent of the serum samples from adults gave positive immunofluorescent reactions against falciparum sporozoites, whereas most of the samples from children gave low or negative reactions. | 1979 | 386511 |
| experimental studies on the effect of proguanil and dapsone against chloroquine-resistant plasmodium berghei (anka) in white mice. | | 1979 | 386963 |
| biochemistry of intraerythrocytic parasites. i. identification of enzymes of parasite origin by starch-gel electrophoresis. | enzymes of parasite origin were identified by starch-gel electrophoresis. the species of parasite studied were plasmodium berghei, plasmodium yoelii nigeriensis, babesia rodhaini and anthemosoma garnhami. lactate dehydrogenase, glucose phosphate isomerase and (nadp) glutamate dehydrogenase were detected in all species; phosphogluconate dehydrogenase was detected in both plasmodium species but malate dehydrogenase only in p. y. nigeriensis. glucose-6-phosphate dehydrogenase, alanine aminotransfer ... | 1979 | 386967 |
| biochemistry of intraerythrocytic parasites. ii. comparative studies in carbohydrate metabolism. | comparative studies were carried out on the glucose catabolism of mouse erythrocytes infected with plasmodium berghei, plasmodium yoelii, babesia rodhaini, babesia microti and anthemosoma garnhami, as well as on uninfected erythrocytes and reticulocytes. the results showed that there was little qualitative difference between the glucose utilization and lactate production of the parasites although quantitative differences between malaria parasites and piroplasms were observed. the rate of glucose ... | 1979 | 386968 |
| abnormal haemoglobins in the sudan savanna of nigeria. ii. immunological response to malaria in normals and subjects with sickle cell trait. | children born in areas hyperendemic for plasmodium falciparum are protected by maternal antibodies for up to about five months of life, after which they are subject to intense infection until they acquire sufficient immunity--by about five years of age. children with sickle cell trait (hb.as) are at an advantage during these critical years, probably because of preferential phagocytosis of parasitized red cells. this could lead to either (i) early processing of antigen by macrophages and an accel ... | 1979 | 386969 |
| studies on plasmodium falciparum in continuous cultivation. i. the effect of chloroquine and pyrimethamine on parasite growth and viability. | recent advances in the in vitro study of human malaria have provided the knowledge to maintain plasmodium falciparum in continuous culture. using relatively cheap and easily obtainable materials it is now possible to study many parameters including parasite chemotherapy. the activity of two standard antimalarials, chloroquine and pyrimethamine, has been examined in vitro. the effect on the parasite is easily observed and can be measured not only as a decrease in parasite density, but also as the ... | 1979 | 386970 |
| genetics of red cells and susceptibility to malaria. | | 1979 | 387115 |
| urea and electrolyte studies in albino rats in plasmodium berghei infection. | | 1979 | 387582 |
| lipid composition and activity of a lytic factor isolated from plasmodium berghei. | a fraction was obtained from plasmodium berghei which induced hemolysis of the erythrocytes of mice and hamsters. this fraction, called lytic factor (lf), was found to be composed of a large amount of lipid material. an examination of the lipids showed the major lipids to be monoglycerides, diglycerides, triglycerides, fatty acids, long-chain alcohol, sterol, sterol ester, sterol glycoside, and two cerebrosides. the most abundant component found in the lf was sterol ester, followed in order by c ... | 1979 | 387594 |
| experimental malaria in the cba/n mouse. | cba/n mice carry an x-linked, recessive gene, which results in the absence of a b cell subset, and is expressed primarily as an inability to respond to a certain class of thymus-independent antigens. we have examined the responses of these mice to the malaria parasite plasmodium yoelii and found that primary infections induced by this parasite are more severe and last longer in mice with x-linked defect than in normal controls. the decreased resistance of the defective mice is associated with a ... | 1979 | 387872 |
| serum opsonic activity in rodent malaria: functional and immunochemical characteristics in vitro. | the functional and immunochemical characteristics of serum opsonic activity in rodent malaria were examined in the present study. schizont- and late trophozoite-enriched populations of plasmodium berghei-infected red blood cells (irbc) were isolated on a ficoll density-gradient and used in an in vitro phagocytosis system composed of serum and monolayer cultures of rat peritoneal macrophages. hyperimmune serum augmented the phagocytosis of irbc to a greater degree than did nonimmune serum. when e ... | 1979 | 387873 |
| chloroquine-resistant falciparum malaria. | | 1979 | 388167 |
| tetraethylthiuram disulfide (antabuse) inhibits the human malaria parasite plasmodium falciparum. | plasmodium falciparum in culture grows optimally at 3% oxygen. oxygen levels down to 0.5% still support growth, but anaerobic conditions do not. these findings, and the absence of the krebs cycle in plasmodium, suggested that in this organism oxygen may not function in electron transport but rather may act through metalloprotein oxygenases. tetraethylthiuram disulfide (antabuse, disulfiram) and its reduction product diethyldithiocarbamate inhibit many metalloprotein oxygenases and have a lipid/h ... | 1979 | 388434 |
| characterization of a protein correlated with the production of knob-like protrusions on membranes of erythrocytes infected with plasmodium falciparum. | membranes of erythrocytes infected with plasmodium falciparum develop protrusions called "knobs." these protrusions are not apparent on erythrocytes infected with young parasites (rings) but develop with the growth of parasites to the trophozoite and schizont stages. the nature and origin of knobs were characterized by comparing the stage-specific proteins of two culture lines of p. falciparum, k+ and k-. k+ parasites produce knobs; k- parasites do not. erythrocytes infected with both types of p ... | 1979 | 388448 |
| different appearance of parasitized erythrocytes in blood between normal and toxoplasma-infected rats after infection of plasmodium berghei. | when normal rats were infected with plasmodium berghei (pb), both igg and igm immunofluorescent antibody titers were found to rise in the 1st week with increase of parasitaemia. after reinoculation of p. berghei into pb-immune rats, igg titer was further increased remarkably, although no parasitaemia was observed. no elevation of igm titer was found. in rats infected with toxoplasma gondii (tg), igg and igm antibody activities were demonstrated in the 1st to the 3rd week postinfection but only i ... | 1979 | 388945 |
| possible chloroquine-resistant plasmodium falciparum in nigeria. | a 42-year-old hospital worker had a recrudescence of falciparum malaria after chloroquine therapy. further adequate treatment with chloroquine given orally did not clear the infection. he was then given a combination of sulphadiazine and pyrimethamine, which produced a radical cure. this points to the possibility of chloroquine-resistant plasmodium falciparum in nigeria, an african country where this has been thought to be unlikely. because of this and earlier reports, clinicians should be on th ... | 1979 | 389072 |
| the enzyme-linked immunosorbent assay (elisa) for malaria. ii. comparison with the malaria indirect fluorescent antibody test (ifa). | | 1979 | 389073 |
| [synthesis of 1-(3-quinolino)-2-alkylaminoethanols (author's transl)]. | | 1979 | 389197 |
| chloroquine-resistant falciparum malaria in a bangladeshi girl with acute lymphoblastic leukaemia. | | 1979 | 389343 |
| chloroquine-resistant plasmodium vivax malaria in infancy and childhood. | | 1979 | 389793 |
| cerebral malaria in the united kingdom. | four fatal cases of cerebral plasmodium falciparum malaria in english travellers returning from africa have been seen in the last 13 years. the haemorrhages, accumulations of microglia, and destruction of cerebral white matter around small veins as a result of blockage of cortical capillaries by parasitised red blood corpuscles resemble the effect of fat embolism. microglia in the lesions is demonstrated by special neuropathological techniques. attention is drawn to the need for a prompt recogni ... | 1979 | 389955 |
| imported parasitic infections in tasmania. | a number of protozoan, trematode, and nematode infections have been imported into tasmania over an 18-month period. some of the cases are briefly discussed as they provide features of clinical interest. the increasing problem of imported infections in australia is emphasized. | 1979 | 390340 |
| cell-mediated immunity in the liver of mice vaccinated against malaria. | mice can be protected against several species of lethal malaria infection by vaccination, and their recovery correlates well with increased anti-malarial antibody levels, particularly igg (ref.2). however, there is also a good correlation between protection by vaccines and priming for delayed-type hypersensitivity in the skin, although there is no obvious explanation for this effect. we now report an apparent relationship between protection and a cell-mediated immune response involving the migra ... | 1979 | 390399 |
| [tropical malaria contracted the natural way in the netherlands]. | | 1979 | 390409 |
| [in vitro cultivation of plasmodium falciparum as a first step in the development of a malaria vaccine]. | | 1979 | 390410 |
| altered erythropoiesis during the course of virulent murine malaria. | | 1979 | 390536 |
| [demonstration of soluble parasite antigens, the corresponding antibodies and immune complexes in acute malaria]. | serum levels of malaria antigens, antimalaria antibodies, immune complexes and complement components have been followed up in 23 patients suffering from acute malaria infection and recovering under therapy. malarial antigens in serum were detected by counterimmunoelectrophoresis: the peak was observed before therapy started and their levels rapidly decreased. specific antimalarial antibodies became detectable 5--7 days after starting treatment in patients with a first infection. immune complexes ... | 1979 | 390695 |
| exchange transfusion in cerebral malaria complicated by disseminated intravascular coagulation. | a patient with cerebral malaria complicated by full-blown dic, after failing to respond to other forms of treatment, was successfully treated by exchange transfusion. to the best of the authors' knowledge, this may be first reported case of full-blown dic in malaria successfully treated by exchange transfusion. | 1979 | 390723 |
| bleeding diathesis in tropical diseases. | | 1979 | 390724 |
| presidential address: a history of malaria and its ironies. | | 1979 | 390821 |
| studies on the occurrence of a strain of chloroquine-resistant plasmodium falciparum in papua new guinea. | | 1978 | 390920 |
| [the infectivity of plasmodium berghei sporozoites during laboratory manipulation]. | | 1979 | 391163 |
| which prophylactic drugs for malaria? | | 1979 | 391331 |
| mean cytoplasmic protein concentration of host erythrocytes and the reticulocyte response in plasmodium berghei infected mice. | the decreasing mean cytoplasmic protein concentration (mpc) of p. berghei host cells is paralled by an increasing parasitemia and percent reticulocyte response. the reticulocyte response parallels the percent parasitemia except during a period of accelerated reticulocytosis noted during the midpoint of the infection at which time the percent reticulocytes increases at a rate more than double the rate of increase of percent parasitemia. although the reticulocyte population and the host cell popul ... | 1979 | 391584 |
| haemoglobin a2 in malaria. | | 1979 | 391709 |
| 2-acetylpyridine thiosemicarbazones. 2. n4,n4-disubstituted derivatives as potential antimalarial agents. | the most effective antimalarial agents among the n4-monosubstituted 2-acetylpyridine thiosemicarbazones recently described by us have a cyclohexyl or a phenyl substituent and produce cures in plasmodium berghei infected mice at a dose of 160 and 320 mg/kg, respectively. we report here on a related series of n4,n4-disubstituted 2-acetylpyridine thiosemicarbazones. several members of this group bearing alkyl or cycloalkyl substituents at n4 show activity superior to the most active monosubstituted ... | 1979 | 392099 |
| treatment and chemoprophylaxis of malaria. | | 1979 | 392489 |
| the concentration of chloroquine in serum during short and long term malaria prophylaxis with standard and 'double' dosage in non-immunes: clinical implications. | the concentration of chloroquine in serum was analysed after one week, six weeks and one year on standard dose prophylaxis (300 mg chloroquine base once a week) and after six months on the double dose. after six weeks, the standard dose gave adequate protection against malaria. during the first weeks of prophylaxis insufficient protection might be achieved by the customary standard dose. in a double-dose group many values reached the point above which a higher incidence of side-reactions have be ... | 1979 | 393188 |
| changes in serum lipoproteins during malariatherapy with plasmodium vivax. | | 1979 | 393192 |
| in vitro response of chloroquine-resistant plasmodium falciparum to mefloquine. | the present study was conducted to evaluate the application of the in vitro microtechnique system in determining the response of chloroquine-resistant plasmodium falciparum to mefloquine.using isolates of p. falciparum from boa vista, brazil, and villavicencio, colombia, mefloquine was more than 7.7, 7.1, 7.1, and 6.4 times more effective than chloroquine in vitro at the ed(90), ed(95), ed(99), and ed(99.9) levels, respectively. | 1979 | 393426 |
| the cultivation of the exoerythrocytic stages of plasmodium berghei from sporozoites. | | 1979 | 393619 |
| serum immunoglobulin concentrations, malarial and schistosomal antibodies in patients with massive splenomegaly in malawi. | serum immunoglobulin concentrations, malarial antibodies and schistosomal antibodies were measured in 33 patients with a provisional diagnosis of schistosomal splenomegaly, 16 with tss of presumed malarial aetiology and in 52 controls. igg and igm were higher in both splenomegaly groups than in the controls and igg was significantly higher in patients with schistosomal splenomegaly than in tss. although a very high igm was found more often in the tss group, there was no significant difference be ... | 1979 | 393837 |
| quartan malarial nephrotic syndrome in children. | quartan malarial infection causes an immune complex nephritis in some individuals, which, once established, is sustained by mechanisms not yet fully explained, but which probably involve autoimmune processes. the presenting clinical and biochemical findings of the quartan malarial nephrotic syndrome are similar to those classically described for the nephrotic syndrome in childhood, but the renal pathology seen on light, electron, and immunofluorescent microscopy show striking differences and dis ... | 1979 | 393890 |
| [epidemiological study of onchocerciasis and malaria in bamendjin dam area (cameroon). malacologic fauna and risks of schistosomian introduction (author's transl)]. | report of survey in bamendjin dam area indicates that 25 p. 100 of the population have a blood smear positive for malaria (p. falciparum) and 80 p. 100 have a positive indirect immunofluorescent test for malaria. the vector is a. funestus. in male inhabitants 23,2 p. 100 of the snip-biopsies are positive for o. volvulus and 40 p. 100 of the indirect immunofluorescent test are positive. in female inhabitants the respective ratios are 14,4 p. 100 and 48,8 p. 100. there is no urinary or intestinal ... | 1979 | 393936 |
| [central nervous system involvement in parasitic tropical diseases]. | | 1979 | 393944 |
| malaria in tonga: an imported case. | a case of falciparum malaria in tonga occurring in a tourist is reported and discussed with the emphasis on awareness of imported diseases to the pacific. | 1979 | 394052 |
| [malaria caused by plasmodium falciparum, with acute renal failure]. | | 1979 | 394232 |
| antisporozoite antibodies in mice immunized with irradiation-attenuated plasmodium berghei sporozoites. | sera from nmri/nih mice were tested for the presence of igm and igg anti-sporozoite antibodies using the indirect fluorescent antibody test (ifat). both igm and igg antibody titres were related to the number of immunizations with irradition-attenuated plasmodium berghei sporozoites, and protection from challenge with subsequent non-attenuated sporozoites correlated with the pre-challenge antibody titre. sera taken five days following challenge showed marked reductions in antibody titres, except ... | 1979 | 394412 |
| in vitro observations on hereditary spherocytosis and malaria. | | 1979 | 394413 |
| abo blood groups and falciparum malaria. | | 1979 | 394415 |
| [synthesis of m6407, a new anti-malarial agent (author's transl)]. | | 1979 | 394574 |
| quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. | a rapid, semiautomated microdilution method was developed for measuring the activity of potential antimalarial drugs against cultured intraerythrocytic asexual forms of the human malaria parasite plasmodium falciparum. microtitration plates were used to prepare serial dilutions of the compounds to be tested. parasites, obtained from continuous stock cultures, were subcultured in these plates for 42 h. inhibition of uptake of a radiolabeled nucleic acid precursor by the parasites served as the in ... | 1979 | 394674 |
| malaria in rural quebec: the impossible infection. | | 1979 | 394827 |
| unexplained falciparum malaria in a patient with chronic lymphocytic leukemia. | | 1979 | 394830 |
| [the reaction of hyperbasophilic mononucleated cells during p. falciparum malaria; its role in the immune response]. | in 34 patients with a primary attack of p. falciparum malaria, hyperbasophilic mononucleated cells (atypical lymphocytes) were found 22 times. these cells appeared around the 3rd or 4th day of fever and represented 4 to 10% of all white blood cells in 14 cases, 10 to 15% in 6 cases, and 15 to 21% in 2 cases. their transitory appearance seems to reflect the involvement of cell-mediated immunity, and more specifically of k cell-related cytotoxicity. | 1979 | 394863 |
| partial suppression of malaria parasites in aedes aegypti and anopheles stephensi doubly infected with nosema algerae and plasmodium. | | 1979 | 395108 |
| hemolymph volume of noninfected and plasmodium berghei-infected anopheles stephensi. | | 1979 | 395256 |
| exoerythrocytic merozoites of plasmodium berghei in rat hepatic kupffer cells. | liver biopsies of white rates infected by plasmodium berghei sporozoites were examined by electron microscopy. intrahepatocytic schizont development was confirmed. in addition, at 60 and 70 h after sporozoite inoculation, exoerythrocytic merozoites were noted in kupffer cells of liver sinusoids. although it is theoretically possible that this observation may be of merozoite development in kupffer cells, the authors suspect that this example of phagocytosis would be one of the host's natural defe ... | 1979 | 395294 |
| gametocytogenesis of plasmodium falciparum in vitro: the cell-cycle. | reproducible growth of gametocytes of plasmodium falciparum in vitro was obtained from ring-stages taken directly from naturally infected patients and from the same material following storage in liquid nitrogen. progressive sexual differentiation in vitro was examined for a finite period of 9 days in microcultures and was, for convenience, divided into 5 stages using established morphological criteria (hawking, wilson & gammage, 1971). this microculture system was adapted as a bioassay for vario ... | 1979 | 395486 |
| the sequestration of plasmodium falciparum infected erythrocytes in the placenta. | | 1979 | 395729 |
| [case of heterozygotic sc hemoglobinopathy with high titre of indirect immunofluorescence reaction with plasmodium falciparum antigen]. | the authors report the first in the polish literature case of combined heterozygotic sc haemoglobinopathy in a nigerian aged 20 years. the diagnosis was based on the results of haemoglobin electrophoresis and clinical signs. the titre of ifp with plasmodium falciparum was very high and malarial pigment was found in lymph nodes. | 1979 | 395806 |
| [imported malaria in a tropical unit in paris. about 100 cases (author's transl)]. | from a hundred cases of imported malaria observed in paris, the authors emphasize the following points: annual increase of cases, lack or inadequacy of prophylaxis, frequent reinfestations among black africans living in france, and comming back in endemic area for a brief journey, high risks for pregnant women. | 1979 | 395872 |
| [myelin-like forms of erythrocytes, monocytes (macrophages) and neutrophilic granulocytes in mice infested with plasmodium berghei (author's transl)]. | | 1979 | 395875 |
| chemotherapy of falciparum malaria: regional differences in responsiveness to treatment. | a review of chloroquine and sulfa-antifol combination treated falciparum malaria patients revealed a high incidence of chloroquine-resistance, wither r1 or r2, in patients infected in southeast asia or oceania. in addition, more than one tenth of the patients infected in laos or thailand were resistant to sulfa-antifol combinations. chloroquine-resistant cases were sensitive to sulfa-antifol combinations. on the other hand, while all patients treated in tokyo who had been infected in africa or s ... | 1979 | 396391 |
| the pattern of parasitic infection in villages of lagos state, nigeria. | | 1979 | 396698 |
| antimalarial activity of the optical isomers of chloroquine diphosphate. | optically pure d- and l-chloroquine diphosphate were examined for their efficacy against plasmodium berghei in mice. the d-enantiomer is significantly more effective than the corresponding l-enantiomer, and in subcurative doses the d-enantiomer is also signficantly more active than the racemate. this increased activity has however no influence upon chloroquine-resistant strains of p. berghei. the ld50 in non-infected mice is higher for the d-enantiomer than for either the racemate or the l-enan ... | 1979 | 396700 |