| cell-mediated immune reactions in vitro to cell walls and peptidoglycan from staphylococcus aureus. | migration inhibition factor (mif) was produced by peritoneal exudate (pe) cells from guinea pigs sensitized with heat-killed cells of staphylococcus aureus cultured in vitro with staphylococcal cell walls or defined subunits of the cell walls. mif activity was assayed by inhibition of migration of alveolar macrophages from lungs of normal guinea pigs. specificity of inhibition was established using pe cells from tuberculin sensitive guinea pigs and tuberculin as appropriate controls. staphylococ ... | 1975 | 126563 |
| inhibition of excision repair without influence upon uv-sensitivity and uv-mutability in escherichia coli b/r hcr+. | pre-irradiation starvation of exponentially growing escherichia coli b/r hcr+ thy-try- strain for thymine and tryptophan causes inhibition of pyrimidine dimer excision from ultraviolet damaged cells dna. this inhibition of excision repair has not resulted in increasing ultraviolet sensitivity nor in increasing frequency of ultraviolet induced tryptophan revertants. the possible mechanisms of the non-excision repair in the prestarved cells, which is at least as accurate and effective as the whole ... | 1975 | 126583 |
| effect of zinc and cadmium on delta-aminolevulinate dehydratase of red blood cells in protecting against enzyme losses during storage. | the effect of zinc and cadmium on delta-aminolevulinate dehydratase of bovine erythrocytes stored at -30 degrees c for different times was determined. the results show a. storage of erythrocytes leads to an enhancement of the enzyme activity, which after six weeks is 165% (500 mum zncl2) respectively 220% (100 mum cdcl2) for red blood cells of calves, and after four weeks in 420% respectively 450% (same concentrations) for red blood cells of adult cattle, b. the older the samples are, the higher ... | 1975 | 126587 |
| neuraminidase treatment enhances the lysolecithin induced intercellular adhesion of amoeba proteus. | egg lysolecithin induces intercellular adhesion of amoeba proteus. pre-treatment of cells with vibrio cholerae neuraminidase (vcn) increases the adhesive property of cells as was evidenced in their formation of larger cell aggregates than controls. a possible role of vcn exposed receptor sites in cellular adhesion is suggested. | 1975 | 126599 |
| [ecology of the cholera vibrions]. | | 1975 | 126601 |
| biogenesis of mitochondria. the effects of membrane unsaturated fatty acid content on the activity and assembly of the yeast mitochondrial protein-synthesizing system. | | 1975 | 126665 |
| [influence of culture on evolution of biological structures in human groups]. | | 1975 | 126716 |
| [effect of some antifibrillatory agents on the isolated rabbit auricle under hypothermia]. | | 1975 | 126723 |
| [optical microscopic study of the effect of the hypothalamic hormone t.r.h. on certain cell types of rat anterior hypophysis]. | a cytological and optical microscopic study of the anterior lobe of hypohysis in the wistar adult rat 10, 30 or 60 minutes after intravenous injection of 50 mug of synthetic trh discloses modifications of thyrotropic cells and prolactin cells. it's possible to recognize a quick degranulation of the prolactin cells (with a maximum at the 10th minute) and a slower degranulation of the thyrotropic cells (perceptible at the 10th minute and very pronounced at the 60th minute). the somatrotopic cells ... | 1975 | 126765 |
| [effect of a beryllium complex on growth of pseudomonas fluorescens (types r and s). i. influence on the lag phase]. | the toxicity of beryllium for pseudomonas fluorescens is studied with the aid of an anionic complex of the element which is stable in peptone medium at ph 6 during the period of investigation. the toxic effect is characterized by an increase in the lag phase which is proportional to the square of the beryllium concentration. further, a process of progressive adaptation is observed when the concentration of the beryllium complex is gradually increased. | 1975 | 126778 |
| letter: safety of retinoic acid in acne therapy. | | 1975 | 126796 |
| [developmental aspects of organism immunoreactivity in vaccination against cholera (author's transl)]. | | 1975 | 126811 |
| effect of methysergide, a blocker of serotonin receptors, on plasma prolactin levels in lactating and ovariectomized rats. | the effect of methysergide (mes, 2.5 mg/100 g body wt), a serotonin antagonist, on prolactin release has been studied in lactating and ovariectomized rats. mes caused significant increases in prolactin release in both animals. studies in ovariectomized, hypophysectomized rats indicate that this effect is not due to a decrease in the peripheral metabolism of prolactin. in vitro incubations of anterior pituitary fragments with mes failed to demonstrate any increase in prolactin release, suggesting ... | 1975 | 126860 |
| tightness and orientation of vesicles from guinea-pig kidney estimated from reactions of adenosine triphosphatase dependent on sodium and potassium ions. | in order to study the "sidedness" of the ligands of the na+, k+-atpase in the phosphorylation from [32p]atp, tight vesicles were prepared from guinea pig kidney and partially purified by a two-stage sucrose and ficoll gradient centrifugation procedure. these vesicles were derived presumably from plasma membrane fragments resealed after the initial disruption of the cells during homogenization. tightness of the vesicles was estimated according to activation by the nonionic detergent, triton x-100 ... | 1975 | 126864 |
| elementary particles in isolated rat liver and spleen nuclear membranes. | elementary spherical particles similar to those described in the mitochondria are found in isolated rat liver and spleen nuclear membranes. the particles are characterized by electron microscopy of sections and preparations negatively stained with phosphotungstic acid or with the atpase histochemical reaction product. the particles exhibit adenosine triphosphatase activity and have a mushroom-like shape with a sphere about 85-90 angstrom in diameter attached to inner face of the inner nuclear me ... | 1975 | 126876 |
| [effect of sensitization on the characteristics of development of experimental atherosclerosis]. | tests were set up on 99 rabbits to study the influence of sensitization with the vascular "atherosclerotic" antigen on the features specific for the development of experimental atherosclerosis. the results obtained bear witness to a variable effect of sensitization that depends upon the timing of the latter. sensitization practised concurrently and right from the beginning of feeding the rabbits on cholesterol introduced some elements of prophylaxis of the experimental atherosclerosis. on the ot ... | 1975 | 127064 |
| the significance of coronary arterial stenosis during cardiopulmonary bypass. | myocardial infarction may develop during an uneventful open-heart operation. in order to better understand this complication, we undertook an experimental study. the left circumflex coronary artery of 20 dogs was narrowed to 50 per cent of its area by a metal screw clamp to produce a localized coronary stenosis. regional myocardial perfusion in the distribution of both the stenotic circumflex and normal left anterior descending (lad) coronary arteries was measured by injection of a radioactive-l ... | 1975 | 127092 |
| [certain ways of regulation of the oxidative processes in the heart in myocardial infarct]. | | 1975 | 127156 |
| antigenic and enzymatic architecture of micrococcus lysodeikticus membranes established by crossed immunoelectrophoresis. | by crossed immunoelectrophoresis with membrane antiserum, 17 antigens have been detected in fractions from plasma membranes of m. lysodeikticus solubilized with triton x-100. absorption tests with protoplasts have demonstrated that eight of the antigens are expressed on the surface. of these antigens the major one has been identified as a succinylated mannan. five of the principal immunoprecipitates unaffected by absorption with protoplasts were shown by zymograms to possess the following enzymi ... | 1975 | 127177 |
| the hurler syndrome: treatment of cultured hurler fibroblasts with normal human serum. | prolonged replacement of fetal calf serum by normal human serum for the enrichment of medium during tissue culture of hurler fibroblasts resulted in increased acid mucopolysaccharides in the cells and in the medium. the predominant intracellular mucopolysaccharide had the characteristics of dermatan sulfate when hurler cells were treated with either serum. normal human serum contains a nonspecific coreective factor capable of augmenting the loss of 35so4-amps from hurler cells, but not from norm ... | 1975 | 127180 |
| [study of anti-t-agglutinins in active and inactivated human sera (author's transl)]. | anti-t-agglutinins were found in 252 of 283 human sera investigated applying the two-step neuraminidase test and using an rde-preparation of czechoslovakian origin. storage and heating of the sera was followed by a reduction or loss of t-agglutination dependent on the time of incubation at 4 degrees c and 56 degrees c. this was proved to be caused by the inactivation of the anti-t-agglutinins and not by the loss of complement. t-transformed erythrocytes absorb anti-t-agglutinins completely. howe ... | 1975 | 127453 |
| studies on plasma membranes. xxiii. hormone-like action of concanavalin a on liver plasma membranes: inhibition of (na+-k+)atpase. | concanavalin a inhibits the (na+-k+)-atpase activity of isolated rat-liver plasma membranes, while leaving the mg2+-atpase unaffected. glucagon and cyclic amp act supplementary to the lectin in the inhibition. the lectin effect is counteracted by insulin and l-epinephrine, and is completely abolished by the beta-adrenergic blocking agent propranolol. results are discussed on the basis of the known interactions of concanavalin a with plasma membrane components, including its hormone-like action. | 1975 | 127672 |
| cadmium-induced experimental fanconi syndrome. | we have demonstrated that repetitive injections of cadmium into rats leads to the abrupt development of fanconi syndrome after the renal cortical concentration of cadmium has increased approximately eighty-fold. the syndrome is temporally associated with a fall in both na-k-atpase activity and atp levels, suggesting a possible causal relationship between altered proximal tubular transport and inhibition of the atp-na-k-atpase transport system. | 1975 | 127688 |
| [androgen metabolism and leydig-cell function in acute and chronic liver disease (author's transl)]. | diurnal variations of plasma testosterone and urinary excretion rates of testosterone-, androsterone-, aetiocholanolone-, and dha-glucuronide, as well as dha-sulphate were measured before and after selective leydig-cell stimulation (with 3 x 5000 iu human gonadotrophin) in eight patients with alcoholic liver cirrhosis, ten with acute hepatitis and four with haemochromatosis. the circadian variation of plasma testosterone and the maximal testosterone concentration after human gonadotrophin stimul ... | 1975 | 127698 |
| [influence of long-term swimming training on the structure and enzyme activity of myosin in the rat myocardium (author's transl)]. | intermittent hemodynamic loading of the rat myocardium due to swimming training for several weeks leads to a significant increase in the specific atpase activity of myosin. this enzymatic alteration of the myosin molecule is accompanied by changes in the stoichiometry of its light chains which are of great significance for the atpase activity. the maximum shortening velocity of the unloaded myocardium (vmax), estimated on the basis of afterloaded contractions, shows a slight increase as a result ... | 1975 | 127740 |
| 'immobile' (im), a recessive lethal mutation of xenopus laevis tadpoles. | 'immobile' (im) is a recessive lethal mutation discovered in the f3 of a xenopus (xenopus laevis laevis) originating from a mesodermal nucleus of a neurula transplanted into an enucleated egg. the im embryos do not contract after mechanical stimulation nor do they present any spontaneous contraction from the neurula stage onwards. development proceeds normally during the first days after which deformation of the lower jaw and tail are observed. the im tadpoles die when normal controls are at the ... | 1975 | 127824 |
| effect of essential phospholipids on the properties of atpases of isolated rat liver plasma membranes of young and old animals. | "essential" phospholipids (epl), rich in dilinoleyl-phosphatidylcholine were given orally to young and 780-800 day-old rats. the double-labelled (14c/32p) dilinoleyl-phosphatidylcholine was incorporated in plasma membranes and the amounts incorporated into different organs investigated. old animals incorporated higher radioactivity than young. the 14c/32p ratio however decreased in comparison with the substance administered. the amount of (na+-k+)-atpase in rat liver plasma membranes of old anim ... | 1975 | 127894 |
| [histochemical and quantitative studies of rna in the thyroid epithelium under the influence of thyrotropic hormone (tsh)]. | | 1975 | 127942 |
| a quantitative model of venous stasis thrombosis in rats. | a quantitative model of stasis-type of venous thrombosis in rats is described. the ligated bowel loop was used after provocation by an injection of kaolin. the mesenteric vessels of the loop were cut in a dish filled with distilled water and the extinction of escaped haemoglobin was measured photometrically. heparin was highly effective in this model. vessel wall lesion may be used or inducing thrombosis instead of kaolin. | 1975 | 128018 |
| [vaccination strategy in influenza]. | the present paper deals with the conditions that influenza vaccines must comply with, their efficiency in terms of the route of administration, the major antigenic changes of influenza viruses, that has to be known from beforehand, a basic problem for the efficient control of a pandemic. vaccination must have in view reduction of the mortality and morbidity rate, a major criterion in establishing a programme for the prevention of influenza by vaccination. | 1975 | 128101 |
| [supplementary data on the theory concerning the cyclic evolution of influenza viruses]. | the distribution per age groups of antibodies to influenza viruses a/hong kong/1/68, a/england/837/69 and a/england/42/72 in the sera collected in 1970 demonstrates that antigenically similar strains also dominated the epidemiologic picture of influenza in the past century. the results suggest that the pandemic of 1893 and infection in persons born before 1885 were caused by a strain similar to a/hong kong/1/68 and in those born in 1895-1897 by the antigenic variant a/england/42/72. the anamnest ... | 1975 | 128105 |
| physiopathological aspect of glynn's type of experimental arthritis. | knee joint arthritis is induced among rabbits previously immunized by intradermal injection with egg albumin (ea) emulsified in adjuvant containing either m. tuberculosis or m. butyricum, then by intra-articular injection with ea. arthritis evolution involves two phases, an early one during the first 2 months and a late one from 3 months to 1 year. during the early phase, arthritis intensities are similar no matter which mycobacterium is used. however, during the late phase, only rabbits immuniz ... | 1975 | 128112 |
| in vitro fertilisation of human oöcytes. | this paper describes attempts to cure infertility due to irremediable fallopian tube lesions by the laparoscopic recovery of pre-ovulatory ovarian oöcytes, their fertilisation in vitro, and their subsequent reimplantation into the uterine cavity. | 1975 | 128140 |
| [some properties of preparations of na+ and k+-atpase treated with deoxycholate]. | the treatment of membrane suspension from the guinea pig kidney cortex possessing na+, + k+ -atpase activity with 0.20% sodium deoxycholate (dox : protein equals 12 : 1) leads to lowering of their enzymatic activity. dox-treated preparation can be divided into two fractions by centrigugation (1 hr - 22 000 g). the pellet has 1.5-fold higher enzymatic activity than the initial preparation and cannot be activated by small amounts of histones. the supernatant has 2-fold lower enzymatic activity tha ... | 1975 | 128167 |
| [histological, histoenzymatic and biochemical study of the liver and small intestine of rats during short periods of starvation]. | the structure and the activity of acid phosphatase, beta-glucuronidase, alkaline phosphatase and atp-ase in the liver and small intestine of rats receiving for 20 days a one-time, fixed at a certain time (2 o'clock) feeding was studied morphologically in dynamics in 2, 6, 24 and 48 hours after the last feeding. furthermore, parallel with this the activity of acid phosphatase, beta-glucuronidase, alpha-glucosidase and beta-acetylglucosaminidase was determined in homogenates by biochemical methods ... | 1975 | 128202 |
| repair of massive septic abdominal wall defects with marlex mesh. | marlex mesh was used to close the abdominal wall defect in six patients with septic wound dehiscence and intra-abdominal infection. the mesh was implanted under local anesthesia and served as a protective covering for the bowel and allowed early ambulation, including prone positioning of the patient for easier wound care. in four surviving patients, the marlex mesh was covered by full thickness skin flaps after granulation tissue had covered the material. no patients had infected sinus tract for ... | 1975 | 128301 |
| editorial: subunits of myosin. relations to atpase activity and mechanical function of muscle. | under certain conditions the specific atpase activity of myosin of a given muscle can be altered. the cause of this alteration can only lie in the myosin molecule itself. to produce an enzymatic activity of myosin, an interaction between their light and heavy chains is necessary. however, the specific activity appears to be determined mainly by light chains. hence, one ought also to look for a basis of the changed activity in changes of the subunits of myosin. there are strong indications that t ... | 1975 | 128346 |
| ascorbic acid and glycosaminoglycan and lipid metabolism in guinea pigs fed normal and atherogenic diets. | the effect of low and high doses of ascorbic acid on glycosaminoglycan and lipid metabolism was studied in guinea pigs fed both normal and atherogenic diets. the high dose of ascorbic acid (25 mg/100 g body weight/day) decreased the cholesterol level in the liver and aorta but not in the serum in animals fed the normal diet in comparison with those fed the low dose of ascorbic acid (0.1 mg/100 g body weight/day). in animals fed the atherogenic diet, cholesterol decreased in the serum and liver, ... | 1975 | 128367 |
| [organization of the veterinary service of a dairy complex]. | | 1975 | 129913 |
| cryopreservation of lymphocytes for use in in vitro assays of cellular immunity. | human lymphocytes can be cryopreserved for the purpose of performing in vitro tests of cellular immunity. a systematic study of the conditions for freezing and recovering cells has shown that there is wide flexibility in cell concentrations of cryoprotective agent and the temperature and rate of dilution however, have definable optima. cells frozen and thawed under optimal conditions retain their reactivity in mlc and can be used for sequential studies of immune responsiveness. approximately 70% ... | 1976 | 130427 |
| cholericidic effect of some intestinal disinfectants. | several compounds have been found which are markedly more effective and more economical as chemoprophylactic agents than the tetracycline compounds traditionally used in cholera-endemic areas. some synergetically acting combinations were shown to exert by several orders of magnitude higher vibriocidal potency than the sum of potency of the compounds when applied singly. in the presence of human intestinal content, however, markedly higher concentrations are needed to exert the proper vibriocidic ... | 1975 | 130761 |
| [newly detected relationships between antibacterial activity and structure of some chalocones]. | | 1976 | 130785 |
| crosslinking of membranes: the effect of dimethylsuberimidate, a bifunctional alkylating agent, on mitochondrial electron transport and atpase. | | 1976 | 130833 |
| cleavage of thrombosthenin a by thrombin. evidence for the existence of two types of bovine platelet actin. | bovin platelet actin prepared by spudich's method (spudich, j. a. (1972) cold spring harbor symp. quant. biol. 27, 585-594) separated into two peaks on a sephadex g-200 column. the actin of both peaks had a mol. wt. of 42 000 on sodium dodecyl sulfate-polyacrylamide gel and activated myosin atpase, although in a quantitatively different manner. actin eluted in the first peak (probably an oligomeric form) was not polymerized in 2 mm mgcl2 and 0.05 m kcl, while that of the second peak went through ... | 1976 | 130929 |
| [spontaneous peripheral proteolysis/1st communication: method and results of clinical examinations (author's transl)]. | with a modificated astrup-fibrin plate-method also an inhibition of proteolysis can be registrated. in various medical areas a spontaneous peripheral proteolysis had been found, especially so in chronical bacterial infections. | 1976 | 132940 |
| [study of the incorporation of radioactive zinc in saccharomyces cerevisiae aldolase]. | saccharomyces cerevisiae aldolase concentrates from the culture medium containing znso4 a large amount of zn which becomes a component part of the enzyme molecular structure. this was made evident by adding to the culture medium 65znso4 and measuring the radioactivity of the aldolase extracted by a phillips single channel analyzer. | 1976 | 133445 |
| evidence of a (na+, k+) atpase activity in human circulating lymphocytes. | | 1976 | 134750 |
| [afferent projections to the locus coeruleus nucleus in the cat. study by the horseradish peroxidase technic]. | using a retrograde tracer technique with horseradish peroxidase, we have revealed some afferent projections to the locus coeruleus complex from the contralateral pontine tegmentum, raphe nuclei, substantia nigra, nucleus of the solitory tract, dorsal motor nucleus of the vagus and other regions of the ponto-bulbar reticular formation as well as from hypothalamic and preoptic areas. | 1976 | 134760 |
| [turnover of free adenine nucleotides of the isolated and perfused rabbit heart]. | the turnover of free adenine nucleotides was studied in the perfused rabbit heart by the decline in radioactivity 3 h 30 after administration of a single pulse of tritiated adenine. the radioactivity of the perfusate was followed during the experiments. about 7% of the labelled adenine nucleotides were renewed by hour and 1,5% of the radioactivity was lossed by hour in the perfusion fluid. | 1976 | 134762 |
| [motricity of the female genital apparatus in mammals. hormonal correlations]. | the motility and the pharmacological reactivity of the uterine tract of mammals are linked with the ovarian cycle and the gestation. in the birds, the study of general scheme of the hormonal mechanism and the uterine motility involued in the ovulation, the egg formation and the uterine dilatation can be used as an experimental model of the mammalian gestation. | 1976 | 134763 |
| [influence of microflora on the metabolism of l-threonine at the level of the rat digestive tract]. | intestinal tissues are found to incorporate l threonine 14cu at faster rate in the absence of microflora. most of the radioactivity of the digestive contents occurs in the tca soluble compounds, except in the coecum and large intestine of the conventional rats where the microflora synthetized its own proteins from the labelled digestive material. free threonine is the main labelled soluble compound in the conventional rats digestive contents. in the other hand, in the germfree rats digestive con ... | 1976 | 134804 |
| [blood on filtration paper for determination of rubella haemagglutination-inhibiting antibodies (author's transl)]. | | 1976 | 134837 |
| glucocorticoid and starvation effect on glycosaminoglycans in vascular connective tissue. biochemical studies on repair processes in rabbit aorta. | male rabbits were injured by a single mechanical dilatation injury of aorta and then injected with prednisone 2 mg/kg or saline for 14 days or subjected to starvation. the biosynthesis of the sulfated glycosaminoglycans as evaluated by the uptake of 35s-sulfate and the content of the glycosaminoglycans were measured on the intima-media layer of the descending thoracic aorta. the results indicate that prednisone may inhibit the biosynthesis of heparan and/or dermatan sulfate while starvation incr ... | 1976 | 134864 |
| a stabilised tris(hydroxymethyl)aminomethane adduct in reduced collagen. | the reduction of collagen with sodium [3h] borohydride in the presence of tris buffer results in the stabilization of a schiff base adduct which is formed between allysine residues and tris(hydroxymethyl)aminomethane. the reduced, radioactive derivative of this adduct has been identified in hydrolyzates or reduced collagen. it elutes before hydroxylysine on an amino acid analyzer column close to the position of dihydroxylysinonorleucine. similar artifacts may occur when aldehydes present in or a ... | 1976 | 134871 |
| the subunits of rabbit-muscle phosphofructokinase. a search for sequence repetition. | rabbit muscle phosphofructokinase uniformly carboxymethylated with iodo[2-14c]acetate consists of subunits with a molecular weight of 80 000 +/- 5000. the subunit polypeptide chain contains 16 and 52 residues respectively of cysteine and arginine and, contrary to previous results, peptide mapping experiments gave no indication that phosphofructokinase chains yield fewer than the expected numbers of cysteine and arginine containing peptides. to test further for the possible occurrence of repeat s ... | 1976 | 134894 |
| the acid mucopolysaccharides (glycosaminoglycans) in secondary cultures of embryonic rat fibroblasts. | in secondary cultures of embryonic rat fibroblasts the protein-free acid mucopolysaccharides were separated by cetylpyridinium chloride fractionation and identified afterwards. the following acid mucopolysaccharides were found: hyaluronic acid, chondroitin, 2 heparan sulphate fractions, chondroitin-4-sulphate, chondroitin-6-sulphate, and dermatan sulphate. | 1975 | 134903 |
| [effects of 4-hydroxypentenal on the noncancerous and the cancerous ectocervix uteri hominis (author's transl)]. | problem: 4-hydroxy-2,3-transpentenal (hpe) represents the 5-c-homologue of a series of hitherto unknown alpha,beta-unsaturated aldehydes. the marked inhibition of dna-biosynthesis by these chemical compounds, particularly by hpe, suggests blocking of mitosis by hpe due to direct action on the s-phase. it is known that dna-biosynthesis as well as energy metabolism are generally more disturbed by hpe in animal tumor cells (ehrlich ascites and solid tumors, nk/ly sarcoma 37, sarcoma 180, plasmocyto ... | 1975 | 134905 |
| dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas. | in the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. novocs 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, and glisoxepide, which were all alike in terms of the relationship between first and second phases of insulin release. | 1976 | 134920 |
| [bdellovibrio bacteriovorus as a factor in the self-purification of river water]. | | 1976 | 134929 |
| dysplasia of the tricuspid valve in the dog and cat. | dysplasia of the tricuspid valve in 14 dogs and 13 cats was studied. the clinical, electrocardiographic, radiographic, hemodynamic, angiocardiographic, and pathologic findings were reviewed in each species. alterations of the tricuspid valve complex included long, thick septal leaflets adhered to the septum; absent or short, stout fused chordae tendineae; hypertrophic fused papillary muscles; insertion of papillary muscles directly into the lateral leaflets; incomplete development of the valvula ... | 1976 | 134984 |
| [on the problem of atypical dysentery bacilli (author's transl)]. | | 1976 | 135237 |
| transplantation of hymenolepis diminuta into naive, immune and irradiated mice. | almost 100% of 7- to 10-day-old hymenolepis diminuta became established when surgically transplanted from donor mice into the duodenum of naive recipient mice. transplanted tapeworms survived 8-12 days, by which time they had survived much longer in total than they would have done in the donor. mice previously immunized by a primary infection rejected transplants within 4 days. sub-lethal irradiation (550 rad) delayed rejection by immune mice but such mice still rejected worms much more quickly ... | 1976 | 135242 |
| liver plasma membrane enzyme activities following glutaraldehyde fixation. | the wachstein-meisel atpase histochemical method has been previously used to demonstrate the ultrastructural localization of this enzyme in both whole liver and isolated plasma membranes following fixation in glutaraldehyde. in the present study biochemical assay, of liver plasma membrane enzymes following fixation in cold 2.5% glutaraldehyde showed that approximately 40% of mg2+-atpase, but only 4% of (na+-k+)-atpase activity remained in membranes from either control or anit-treated rats. in ad ... | 1976 | 135243 |
| cerium nitrate: a new topical antiseptic for extensive burns. | the wounds of 60 burned patients were treated topically with cerium nitrate, which was applied either as a cream or in aqueous solution. cerium nitrate has a potent antiseptic effect in human burn wounds, especially against gram negative bacteria and fungi. pseudomonas aeruginosa was recovered from the wounds infrequently and never predominated. fungi were practically never found. no patient treated with cerium developed a necrotizing wound infection. analysis of the detailed bacteriological dat ... | 1976 | 135364 |
| suppressor mechanisms in neonatally acquired tolerance to a gross virus-induced lymphoma in rats. | tolerance to a highly immunogenic gross virus-induced tumour in wistar/furth rats (c58nt)d was produced by neonatal infection of the rats with the virus. these rats failed to reject the tumours when challenged 8 weeks after virus inoculation and to mount the appropriate cell-mediated immune response to the tumour. the mechanisms involved were studied in vivo by adoptive transfers into sub-lethally irradiated rats of tumour cells mixed with spleen cells and/or sera from normal, tolerant, or tumou ... | 1976 | 135385 |
| effect of testosterone administration on the epiphyseal cartilage of hypophysectomized rats. | for the study of the mechanism of action of testosterone histological, carbohydrate-, and enzyme histochemical investigations were carried out on the epiphyseal cartilage of (1) hypophysectomized rats treated with testosterone [(thx group); (2)] hypophysectomized rats without hormonal treatment (hx group), and (3) intact, untreated control rats. the results were compared with the data obtained in a previous experiment in which intact rats were treated with testosterone (t group). the experiments ... | 1976 | 135467 |
| effect of vibrio cholerae neuraminidase on the generation of cell-mediated cytotoxicity in vitro. | vibrio cholerae neuraminidase (vcn))12.5 units/2 x 10(6) cells/ml) continuously present for a standard 5-day mlc will significant (p less than 0.02) increase the cytotoxic activity generated by a given number of responding spleen cells without reducing the specificity. heat-inactiviated vcn produced no such augmentation. this augmented cytotoxicity could be reproduced by preincubating (1 hr) the responding spleen cells with vcn (25 units/2.5 x 10(6) cells/ml) before addition of stimulating splee ... | 1976 | 136474 |
| tobacco, auxiliary etiologic factor of cancer of the larynx and hypopharynx]. | | 1976 | 136491 |
| induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody iv: effect of injection of hgcl2 prior to the antibody. | autologous immune-complex glomerulonephritis developed in rats injected s.c. with hgcl2 2 days before the injection of anti-tubular fraction 3 antibody. the glomerulonephritis was progressive and characterized by granular deposition of igg and c-3, with proteinuria from the eighth week onwards. granular densities and severe glomerular basement membrane changes were observed when the experiment was terminated after 9 months. a possible mechanism of the glomerular lesion is discussed. | 1976 | 136979 |
| [reversal of the depressive power of cyclophosphamide on the anti-infectious defense of the mouse by means of a somatic antigen from bacillus subtilis]. | in the experimental conditions reported the cyclophosphamide increases the pathogenic effect of escherichia coli in mice. treating the animals with a somatic antigen of bacillus subtilis, reverses the aggravating effect of cyclophosphamide on the experimental infection. similar results are obtained through the parenteral and the rectal routes. this antigen does not limit either the leucopenient effect of cyclophosphamide nor its blocking effect on the synthesis of sheep red blood cells antibody ... | 1976 | 137039 |
| hyperkeratosis of the palms and soles associated with internal malignancy and elevated levels of immunoreactive human growth hormone. | | 1976 | 137091 |
| studies of the histochemistry, ultrastructure, motor innervation, and regeneration of mammalian intrafusal muscle fibres. | | 1976 | 137430 |
| fine-structural localization of phosphatase activity on the plasma membrane of the rabbit sperm head. | | 1977 | 137973 |
| biochemical actions of sympathomimetic drugs which overcome cycloheximide-induced amnesia. | earlier investigations of sympathomimetic drugs overcoming the amnesic action of cycloheximide (cxm) in day-old chickens were extended to biochemical studies in vitro. the effects of amphetamine, norepinephrine, alpha and beta noradrenergic stimulants and receptor blockers on na+/k+ atp'ase activity in total homogenate of chicken forebrain were investigated. norepinephrine and the beta stimulant, isoprenaline significantly stimulated the activity of this enzyme, while the beta blocker, propranol ... | 1976 | 138858 |
| leukaemogenesis in down's syndrome. | due to the fixed karyotype and documented malignancy risk in patients with down's syndrome, recently described aetiological factors can be assigned to their proper places in a conceptual framework for leukaemogenesis in these individuals. this is a more profitable approach than those in which various types of karyotypic patterns are matched to different malignancies. it seems that viruses may play a special role, but they need interaction with other factors, most of which are present in down's s ... | 1977 | 138950 |
| [age dependent frequency of cytoplasmic antibodies]. | in a random sample of so-called healthy blood donors under and over 60 years of age (n=196 of 10,593 donations by about 4254 donors) the frequency of antibodies (antibodies against smooth muscles, mitochondria, microsomes, brush border of proximal rat renal tubuli, connective tissue, and parietal cells) detectable by immuno-fluorescence was determined and compared with the incidence thereof in various groups of diseases. in general, two frequency peaks (up to 30 and over 50 years of age) were ob ... | 1976 | 139091 |
| mechanism of action of choleragen. evidence for adp-ribosyltransferase activity with arginine as an acceptor. | choleragen catalyzed the hydrolysis of nad to adp-ribose and nicotinamide; nicotinamide production was dramatically increased by l-arginine methyl ester and to a lesser extent by d- or l-arginine, but not by other basic amino acids. guanidine was also effective. nicotinamide formation in the presence of l-arginine methyl ester was greatest under conditions previously shown to accelerate the hydrolysis of nad by choleragen (moss, j., manganiello, v. c., and vaughan, m. (1976) proc. natl. acad. sc ... | 1977 | 139409 |
| mechanical properties of cardiac muscle from spontaneously hypertensive rats: accentuated aftercontractions. | | 1977 | 139613 |
| morphine and 5-hydroxytryptamine interactions in rat hypothalamus and pineal body. | | 1977 | 140058 |
| recovery of preimplantation blastocysts in the squirrel monkey by a laparoscopic technique. | a laparoscopic uterine flushing technique has been developed for the recovery of preimplantation embryos from the squirrel monkey. fourteen adult female squirrel monkeys were induced to ovulate with 4 or 5 days' treatment with follicle-stimulating hormone (1 mg) followed by human chorionic gonadotropin (hcg) (500 iu). natural mating with a fertile male or artificial insemination was performed near the time of ovulation. thirty-six hours and eleven days after hcg administration, the females were ... | 1977 | 140077 |
| preparation of human immunoglobulin free of plasmin and anticomplement activities. | human igg separated by cohn fractionation showed variability in the content of aggregates, plasminogen and anticomplement activity. the plasminogen was removed or markedly reduced by affinity chromatography on sepharose-lysine. anticomplement activity was reduced by chromatography of cohn fraction ii on deae-cellulose. preparations of igg obtained by chromatography of intermediates from cohn fractionation (e.g. cohn fii + fiii or fii + fiii w) on deae-cellulose were devoid of aggregates, plasmin ... | 1977 | 140530 |
| differential effects of t-lymphocyte-derived soluble factor on virgin and primed b lymphocytes in vitro. | cell-free supernatants from mixed leukocyte cultures derived from histoincompatible mouse strains markedly enhanced the in vitro immune response to srbc by splenocytes from allogeneic mice. the supernatant factor or factors from allogeneic spleen cell cultures appeared to preferentially stimulate antigen-sensitized b lymphocytes, especially those involved in secondary igg antibody formation. furthermore, as shown in the present study, the enhancing supernatant factor or factors had no effect on ... | 1977 | 141139 |
| loss of striatal serotonin synaptic receptor binding induced by kainic acid lesions: correlations with huntington's disease. | | 1977 | 142820 |
| acid mucopolysaccharides in metal-induced tumor and connective tissue capsules surrounding implants in rats. | | 1975 | 142824 |
| [electron-cytochemical distribution of acetylcholinesterase, monamine oxidase and mg2+-atpase in the human hypothalamus]. | the distribution of acetylcholinesterase, monoaminoxidase and atp-ase was studied in human hypothalamus by means of electron microscopy. the study demonstrated a possibility of differentiation of the hypothalamic neurons according to phases of neurosecretion. these data were achieved on the basis of electron cytochemistry in detecting atp-asa in the nuclei of neurons. comparing literary data concerning the nonmediator role of acetyl-choline and catecholeamines with personal studies, the authors ... | 1977 | 143176 |
| [enzymomorphology in cholerogenic intoxication in suckling rabbits]. | the cholerogenic effect produced in suckling rabbits by intraintestinal administration of a cholerogen was shown to be accompanied by the edema of villi, formation of lympho-histiocytic infiltrates in the stroma and bases of crypts, hemorrhages in the stroma of the villi and loss of individual enterocytes mostly on tops of the villi. in the large intestine, vacuolation and pyknosis of the epithelial nuclei and edema of the submucosa were observed. the intensity of the cholerogenic effect correla ... | 1977 | 143262 |
| iteraction of halothane with non-depolarizing neuromuscular blocking drugs in man [proceedings]. | | 1977 | 143292 |
| [antigenic relations between vibrio cholerae and aeromonas hydrophila]. | the antigenic relationships between vibrio cholerae and the oxidase-positive intestinal bacteria, agglutinated on slides by cholera antiserum, were investigated by the agglutination reaction. of the 478 oxidase-positive strains studied only strain 209 a, belonging to species aeromonas hydrophila was selected. evidence was found of common agglutinogenic fractions between vibrio cholerae and aeromonas hydrophila 209 a. attention is drawn to possible confusions in the preliminary stages of a labora ... | 1977 | 143704 |
| [demonstration of the variations in accessibility or reactivity of mitochondrial sh groups according to the energy status of the mitochondria]. | evidence for energy dependent variations of mitochondrial sh groups accessibility or reactivity was obtained using alkylating agents. these variations are thought to be consecutive to conformational changes affecting some proteins among them the phosphate carrier and the adenylic nucleotide translocator. | 1977 | 145307 |
| [t-cell subpopulations in mixed lymphocyte cultured. model of t-cell interactions]. | the present studies have shown that two subpopulations of thymus-dependent lymphocytes may act synergisticaly in the mixed lymphocyte reaction (mlr) in the mouse. one subpopulation was well represented in the young adult thymus and the other in lymph nodes. for optimum synergy, both populations must be allogeneic to the stimulator cells. pretreatment of either population with mitomycin-c abolished synergy. in a cinetic study lymph node cells were proliferating before thymus cells. a mixture of t ... | 1977 | 145401 |
| variation in potassium transport properties of mouse 3t3 cells as a result of subcultivation. | unindirectional potassium influx and the fraction of this influx sensitive to ouabain, an inhibitor of the (na + k) activated atpase, have been evaluated as a function of subcultivation of the 3t3 and sv40 transformed 3t3 cell. total and ouabain-sensitive k influx change little over approximately 50 passages of the transformed 3t3 cell. in contrast, these components of k influx increase nearly 5-fold over a similar number of passages of the 3t3 cell. during early passages total and ouabain-sens ... | 1977 | 145445 |
| effect of p-chlorophenylalnine on the loss and maintenance of tolerance to ethanol. | rats were rendered tolerant to the motor-impairing effects of ethanol by daily oral administration. subsequently, ethanol was withdrawn and the effect of p-chlorophenylalanine (p-cpa) on tolerance loss was examined. in two separate studies it was demonstrated that p-cpa, in a dosage regimen that produces extensive depletion of brain serotonin (5-ht), accelerated tolerance loss. these experiments suggest that at least part of p-cpa's inhibitory effect on net tolerance development to ethanol can b ... | 1978 | 148066 |
| developmental patterns of peripheral nerve, myoneural junction and muscle: a review. | | 1977 | 148071 |
| cerebral aterial spasm. i. adrenergic mechanism in experimental cerebral vasospasm. | this study demonstrates that an adrenergic mechanism plays an important role in producing the delayed cerebral vasospasm which follows subarachnoid hemorrhage. results were as follows: 1. experimental subarachnoid hemorrhage (sah) was produced by injection of fresh arterial blood into the cisterna magna in cats. the cerebral vasospasm was shown angiographically to be biphasic in nature: immediate constriction lasting 1 h and marked prolonged spasm occurring between the 3rd and 5th day after sah. ... | 1978 | 148833 |
| laparoscopic examination of the reproductive tracts of gilts using a special crate. | a crate for restraining gilts for routine laparoscopic examination of the reproductive tract is described, together with the techniques employed in anaesthesia and laparoscopy. the procedure is efficient, allowing two operators to examine 4-5 gilts per hour. | 1978 | 148883 |
| [characteristics of the toxicological action of carbophos against a background of polychloropinene]. | tests conducted with rabbits brought evidence that carbophos priming per os (1/25dl50 for 45 days) reduces the oxyhemoglobin dissociation rate, increases the ascorbic acid concentration in the blood and brain, of copper in the blood, brain and kidneys. priming with a mixture of carbophos and polychloropinene (in a summary dose of 1/25dl50) was attended by a decline in the oxyhemoglobin, rising a concentration of ascorbic acid in the blood, of manganese in the kidneys and iron in the muscles. cha ... | 1978 | 149023 |
| the multicomposite structure of tendon. | a revised morphological model for the crimp structure of tendon is presented. the 300-500 mu diameter tendons of the mature rat tail are comprised of from one to more than ten substructures, called fascicles, of 80-320 mu diameter. fascicles each possess a "crimp structure" demonstrable in the polarizing microscope and neighboring fascicles within a tendon usually exhibit crimp registry. the fascicle itself is shown to be a cylindrical array of planar-zig-zag crimped 500-5000 a diameter collagen ... | 1978 | 149646 |
| siderophore production by vibrio cholerae. | vibrio cholerae produces a phenolate-type siderophore that stimulates growth of the organism in low-iron medium. this compound is similar, but not identical, to enterochelin, the siderophore produced by salmonella and escherichia coli. | 1978 | 149768 |
| correlation of electron microscopic and secretory response of human parathyroid adenomas with different calcium concentrations in organ culture. | twelve parathyroid chief cell adenomas from patients with primary hyperparathyroidism were incubated in a tissue culture system in the presence of different calcium concentrations and for various time periods. the endocrine response of the tissue was examined electron microscopically and radioimmunologically. after incubation in a medium of low calcium concentration the parathyroid adenomas showed ultrastructural signs of stimulation with proliferation of the hormone-synthesizing organelles. the ... | 1978 | 150111 |
| immunoglobulin and complement deposits in the lungs of new zealand black/white mice. | forty-four new zealand black/white (nzb/w) f1 hybrid mice were studied for evidence of immune complex deposition in the lungs and kidneys. positive immunofluorescence was seen in the lungs of 27 mice. the pattern of lung fluorescence was granular in association with capillary walls in 16 mice and intracellular in 12. the incidence of granular fluorescence was increased with age and was seen in 80% of the lungs of mice over 13 months old. there was a correlation between capillary wall fluorescenc ... | 1978 | 150120 |