| effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. | curcumin is the most active component of turmeric. it is believed that curcumin is a potent antioxidant and anti-inflammatory agent. tetrahydrocurcumin (thc) is one of the major metabolites of curcumin, and exhibits many of the same physiological and pharmacological activities as curcumin and, in some systems, may exert greater antioxidant activity than curcumin. using circulating erythrocytes as the cellular mode, the insulin-binding effect of thc and curcumin was investigated. streptozotocin ( ... | 2008 | 18376071 |
| curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappab-regulated gene products. | how colorectal cancer develops resistance to gamma-radiation is not fully understood, but the transcription factor nuclear factor-kappab (nf-kappab) and nf-kappab-regulated gene products have been proposed as mediators. because curcumin, a component of turmeric (curcuma longa), has been shown to suppress nf-kappab activation, whether it can sensitize the colorectal cancer to gamma-radiation was investigated in colorectal cancer xenografts in nude mice. | 2008 | 18381954 |
| multi-targeted therapy by curcumin: how spicy is it? | although traditional medicines have been used for thousands of years, for most such medicines neither the active component nor their molecular targets have been very well identified. curcumin, a yellow component of turmeric or curry powder, however, is an exception. although inhibitors of cyclooxygenase-2, her2, tumor necrosis factor, egfr, bcr-abl, proteosome, and vascular endothelial cell growth factor have been approved for human use by the united states food and drug administration (fda), cu ... | 2008 | 18384098 |
| effects of spice constituents on p-glycoprotein-mediated transport and cyp3a4-mediated metabolism in vitro. | the effects of eight components from six commonly consumed spices on p-glycoprotein (p-gp) transport and cyp3a4 metabolism were evaluated in vitro. p-gp-mediated [(3)h]digoxin fluxes across the l-mdr1 (llc-pk1 cells transfected with human mdr1 gene) and caco-2 (human colon carcinoma) cell monolayers showed a marked asymmetry compared with that in the llc-pk1 (porcine kidney epithelial cells) cell monolayers. curcumin (from turmeric) at 30 to 60 microm and 6-gingerol (from ginger) at 100 to 500 m ... | 2008 | 18385293 |
| plant crude extracts could be the solution: extracts showing in vivo antitumorigenic activity. | screening active compounds from plants lead to discover new medicinal drugs which have efficient protection and treatment roles against various diseases including cancer. in our study, extracts from different plants represent seeds of: gossypium barbadense, ricinus communis, sesamum indicum, nigella sativa, vinca rosea and melia azedarah; fruits of: xanthium occidental; flowers of: atriplex nummularia; barks of: cinnamomum zeylanicum; latex of: ficus carica and rhizomes of: curcuma longa and zin ... | 2008 | 18390447 |
| a mechanistic approach for modulation of arsenic toxicity in human lymphocytes by curcumin, an active constituent of medicinal herb curcuma longa linn. | chronic exposure of humans to high concentrations of arsenic in drinking water is associated with skin lesions, peripheral vascular disease, hypertension, blackfoot disease and a high risk of cancer. arsenic induces single strand breaks, dna-protein crosslinks and apurinic sites in dna, which are prerequisites for induction of cancer. amelioration of such damages with natural compounds could be an effective strategy to combat arsenic toxicity. curcumin is the active ingredient of turmeric, a com ... | 2007 | 18392098 |
| curcumin inhibits wehi-3 leukemia cells in balb/c mice in vivo. | curcumin (1, 7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5- dione), a natural polyphenol product of the plant curcuma longa, exhibited potent inhibitory activities against proliferation, induced cell cycle arrest and exhibited the induction of apoptosis in several tumor cell lines. in our previous studies, we have shown that curcumin induced cell cycle arrest and apoptosis on human leukemia hl-60 and mouse leukemia wehi-3 cells; there are no reports regarding whether or not it affects leuk ... | 2008 | 18396784 |
| curcumin inhibits btrek-1 k+ channels and stimulates cortisol secretion from adrenocortical cells. | bovine adrenal zona fasciculata (azf) cells express btrek-1 k(+) channels that set the resting membrane potential. inhibition of these channels by adrenocorticotropic hormone (acth) is coupled to membrane depolarization and cortisol secretion. curcumin, a phytochemical with medicinal properties extracted from the spice turmeric, was found to modulate both btrek-1 k(+) currents and cortisol secretion from azf cells. in whole-cell patch clamp experiments, curcumin inhibited btrek-1 with an ic(50) ... | 2008 | 18406348 |
| effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats. | changes in glycoconjugate metabolism during the development of diabetic complications and their modulation by feeding bitter gourd and spent turmeric as fiber-rich source. | 2009 | 18413160 |
| inhibition of nod2 signaling and target gene expression by curcumin. | nod2 is an intracellular pattern recognition receptor that detects a conserved moiety of bacterial peptidoglycan and subsequently activates proinflammatory signaling pathways. mutations in nod2 have been implicated to be linked to inflammatory granulomatous disorders, such as crohn's disease and blau syndrome. many phytochemicals possess anti-inflammatory properties. however, it is not known whether any of these phytochemicals might modulate nod2-mediated immune responses and thus might be of th ... | 2008 | 18413660 |
| curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating trkb. | curcumin is a major active component isolated from curcuma longa. previously, we have reported its significant antidepressant effect. however, the mechanisms underlying the antidepressant effects are still obscure. in the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of brain-derived neurotrophic factor (bdnf), which is deeply involved in the etiology and treatment of depression. ex ... | 2008 | 18420184 |
| the anti-inflammatory effects of curcuma longa and berberis aristata in endotoxin-induced uveitis in rabbits. | to investigate the anti-inflammatory effect of topical application of curcuma longa (c. longa) and berberis aristata (b. aristata) aqueous extracts on experimental uveitis in the rabbit. | 2008 | 18421073 |
| antioxidant and iron-binding properties of curcumin, capsaicin, and s-allylcysteine reduce oxidative stress in rat brain homogenate. | research demonstrates that antioxidants and metal chelators may be of beneficial use in the treatment of neurodegenerative diseases, such as alzheimer's disease (ad). this study investigated the antioxidant and metal-binding properties of curcumin, capsaicin, and s-allylcysteine, which are major components found in commonly used dietary spice ingredients turmeric, chilli, and garlic, respectively. the dpph assay demonstrates that these compounds readily scavenge free radicals. these compounds si ... | 2008 | 18422331 |
| [effect of zedoary turmeric oil on proliferation, apoptosis and extracellular matrix secretion of hepatic stellate cells]. | | 2008 | 18423156 |
| curcumin induces apoptosis in hct-116 human colon cancer cells in a p21-independent manner. | several micronutrients present in fruits and vegetables exhibit anticancer activity as a result of their actions on molecular targets involved in carcinogenesis and tumor progression. curcumin, a phenolic phytochemical derived from the rhizome of curcuma longa, exhibits both cancer-preventative activity and growth inhibitory effects on neoplastic cells. several studies report that curcumin inhibits cancer cell proliferation and induces apoptosis in cancer cells through p21-mediated cell cycle ar ... | 2008 | 18423603 |
| mosquito larvicidal activity of botanical-based mosquito repellents. | the larvicidal activity of 4 plant essential oils--innamon oil, lemon eucalyptus oil, sandalwood oil, and turmeric oil--previously reported as insect repellents was evaluated in the laboratory against 4th instars of aedes albopictus, ae. aegypti, and culex pipiens. sandalwood oil appeared to be the most effective of the larvicides, killing larvae of all 3 mosquito species in relatively short times. the values of lt50 and lt90 at the application dosage (0.2 mg/ml) were 1.06 +/- 0.11 and 3.24 +/- ... | 2008 | 18437833 |
| preparation and characterization of herbal creams for improvement of skin viscoelastic properties. | the aim of this study was to formulate and evaluate herbal cosmetic creams for their improvement of skin viscoelastic and hydration properties. the cosmetic cream formulations were designed by using ethanolic extracts of glycyrriza glabra, curcuma longa (roots), seeds of psorolea corlifolia, cassia tora, areca catechu, punica granatum, fruits of embelica officinale, leaves of centella asiatica, dried bark of cinnamon zeylanicum and fresh gel of aloe vera in varied concentrations (0.12-0.9%w/w) a ... | 2008 | 18452435 |
| effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects. | high oxalate intake resulting from consuming supplemental doses of cinnamon and turmeric may increase risk of hyperoxaluria, a significant risk factor for urolithiasis. | 2008 | 18469248 |
| curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. | because most cancers are caused by dysregulation of as many as 500 different genes, agents that target multiple gene products are needed for prevention and treatment of cancer. curcumin, a yellow coloring agent in turmeric, has been shown to interact with a wide variety of proteins and modify their expression and activity. these include inflammatory cytokines and enzymes, transcription factors, and gene products linked with cell survival, proliferation, invasion, and angiogenesis. curcumin has b ... | 2008 | 18479807 |
| curcuma oil modulates the nitric oxide system response to cerebral ischemia/reperfusion injury. | the antioxidant activity of c.oil in cerebral stroke has been reported earlier. we have attempted here to clarify the mechanisms underlying the neuroprotection against experimental cerebral ischemia by curcuma oil (c.oil), isolated from the rhizomes of curcuma longa. c.oil (250 mg/kg i.p.) was given 30 min before focal ischemia in rats caused by occlusion of the middle cerebral artery (1h of occlusion, 24h of reflow). ischemia, leads to elevation in [ca(2+)] this sets into motion a cascades of i ... | 2008 | 18485279 |
| curcumin reduces the toxic effects of iron loading in rat liver epithelial cells. | iron overload can cause liver toxicity and increase the risk of liver failure or hepatocellular carcinoma in humans. curcumin (diferuloylmethane), a component of the food spice turmeric, has antioxidant, iron binding and hepatoprotective properties. the aim of this study was to quantify its effects on iron overload and the resulting downstream toxic effects in cultured t51b rat liver epithelial cells. | 2009 | 18492020 |
| efficacy of turmeric (curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. | a 3-wk feeding study was conducted to evaluate the efficacy of turmeric (curcuma longa) powder (tmp), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate (hscas; improved milbond-tx, imtx, an adsorbent, milwhite inc., houston, tx) to ameliorate the adverse effects of aflatoxin b(1) (afb(1)) in broiler chicks. four pen replicates of 5 chicks each were assigned to each of 7 dietary treatments, which included the basal diet not containing tmp, hscas, or afb(1) (contr ... | 2008 | 18493001 |
| curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of mmps and upa. | curcumin (cur), a component of turmeric (curcuma longa), has been reported to exhibit antimetastatic activities, but the mechanisms remain unclear. other curcuminoids present in turmeric, demethoxycurcumin (dmc) and bisdemethoxycurcumin (bdmc) have not been investigated whether they exhibit antimetastatic activity to the same extent as curcumin. the regulation of matrix metalloproteinases (mmps) and urokinase plasminogen activator (upa) play important role in cancer cell invasion by cleavage of ... | 2009 | 18495463 |
| inhibitory effects of 150 plant extracts on elastase activity, and their anti-inflammatory effects. | the inhibitory effects of 150 medicinal plants on elastase activity were investigated. among the 150 plants, six plant extracts (final concentration 1 mg/ml in methanol) exhibited more than 65% of inhibition of elastase activity. the inhibitory effects of six active plants, including areca catechu (ic50, 42.4 mug/ml), cinnamonum cassia (ic50, 208.7 mug/ml), myristica fragrans (ic50, 284.1 mug/ml), curcuma longa (ic50, 398.4 mug/ml), alpinia katsumadai (ic50, 465.7 mug/ml) and dryopteris cassirrh ... | 1999 | 18505532 |
| [effect of zedoary turmeric oil-eluting stents for post-stenting restenosis prevention and treatment]. | to investigate the effect and safety of zedoary turmeric oil (zto)-eluting stents for post-coronary stenting restenosis prevention and treatment in the experimental dogs. | 2008 | 18543486 |
| pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. | curcumin is a polyphenol, found in the spice turmeric, that has promising anticancer properties, but previous studies suggest that absorption of curcumin may be limited. | 2008 | 18559556 |
| curcumin protected pc12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. | one of the pathological hallmarks of alzheimer's disease is the progressive accumulation of beta-amyloid (abeta) in the form of senile plaques, and abeta insult to neuronal cells has been identified as one of the major causes of the onset of the disease. curcumin, the major and most active antioxidant of curcuma longa, protects neuronal cells against abeta-induced toxicity. therefore, in this study, we investigated the neuroprotective mechanisms by which curcumin acts against abeta (25-35)-induc ... | 2008 | 18573304 |
| possible nitric oxide modulation in protective effect of (curcuma longa, zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice. | sleep is essential for the physical and mental health of a human being. problems of sleep deprivation are increasing in modern society nowadays. recently, various antioxidants have been implicated as neuroprotectants in the treatment of stress and stress related problems. the present study was designed to explore the possible role of nitric oxide in the protective effect of curcumin (curcuma longa, zingiberaceae) against 72-h sleep deprivation-induced behavioral alterations and oxidative damage ... | 2008 | 18586477 |
| curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against ccl4-induced liver injury in rats. | curcumin and saikosaponin a, the bioactive phytochemicals of turmeric and bupleurum, act as antioxidants. this study investigated the effects of supplementation with curcumin and/or saikosaponin a on hepatic lipids and antioxidant status in rats with ccl(4)-induced liver injury. male sprague-dawley rats were randomly divided into control, ccl(4), ccl(4) + curcumin (0.005%; cu), ccl(4) + saikosaponin a (0.004%; ss), and ccl(4) + curcumin + saikosaponin a (0.005% + 0.004%; cu+ss) groups. ccl(4) (4 ... | 2008 | 18598162 |
| bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of vcam-1 expression. | bisacurone, one of the active compounds of the traditionally used indigenous herb curcuma longa linne (zingiberaceae), has anti-oxidant, anti-inflammatory, and anti-metastatic activities. we studied how the level of vascular cell adhesion molecule-1 (vcam-1), one of the key molecules in the development of atherosclerosis as well as carcinogenesis and metastasis, might be affected by bisacurone in tumor necrosis factor-alpha (tnf-alpha)-activated human umbilical vein endothelial cells (huvecs). b ... | 2008 | 18602074 |
| dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat. | curcumin (diferuloylmethane), an active ingredient of turmeric, obtained from the powdered rhizomes of curcuma longa linn., has been traditionally recognized for treatment of several diseases. to evaluate the potential clinical use of curcumin, we determined the dose dependence of its effects in the therapeutic window and of the neuroprotective efficacy in a cerebral thromboembolic model of the rat. rats were subjected to occlusion of the middle cerebral artery (mcao) by a thrombus and treated w ... | 2008 | 18611416 |
| calebin-a induces apoptosis and modulates mapk family activity in drug resistant human gastric cancer cells. | this study is the first to investigate calebin-a, a natural compound present in curcuma longa, which inhibits cell growth and induce apoptosis in sgc7901/vincristine cells, a multidrug resistant (mdr) human gastric adenocarcinoma cell line. our data suggest the drug efflux function of p-glycoprotein was inhibited by calebin-a treatment, while the expression level of p-glycoprotein was not affected. additionally, co-treatment of calebin-a and vincristine resulted in a remarkable reduction in s ph ... | 2008 | 18619958 |
| [analytical method for carbamate pesticides in processed foods by lc/ms/ms]. | a rapid analytical method for the simultaneous determination of carbamate pesticides in processed foods was established by liquid chromatography coupled with tandem mass spectrometry (lc/ms/ms). the pesticides were extracted from samples with acetonitrile using accelerated solvent extract equipment, except for the fine powder type spices, which were extracted in an ultrasonic bath. the crude extract was cleaned up with a multi-solvent gpc column (shodex asahipak gf-310 hq) using acetonitrile as ... | 2008 | 18633196 |
| curcumin prevents human dendritic cell response to immune stimulants. | curcumin, a compound found in the indian spice turmeric, has anti-inflammatory and immunomodulatory properties, though the mechanism remains unclear. dendritic cells (dcs) are important to generating an immune response and the effect of curcumin on human dcs has not been explored. the role curcumin in the dc response to bacterial and viral infection was investigated in vitro using lps and poly i:c as models of infection. cd14(+) monocytes, isolated from human peripheral blood, were cultured in g ... | 2008 | 18639521 |
| evaluation of widely consumed botanicals as immunological adjuvants. | many widely used botanical medicines are claimed to be immune enhancers. clear evidence of augmentation of immune responses in vivo is lacking in most cases. to select botanicals for further study based on immune enhancing activity, we study them here mixed with antigen and injected subcutaneously (s.c.). globo h and gd3 are cell surface carbohydrates expressed on glycolipids or glycoproteins on the cell surface of many cancers. when conjugated to keyhole limpet hemocyanin (klh), mixed with an i ... | 2008 | 18640165 |
| inhibitory effects of spices and herbs on iron availability. | spices and herbs are extensively used in indigenous diets in tropical regions where prevalence of iron deficiency is still high. they are rich in polyphenolic compounds that are expected to inhibit iron absorption by forming iron complexes in the intestine, making dietary iron less available for absorption. the effects of six spices and herbs (chili pepper, garlic, 'pak kyheng' (thai leafy vegetable), shallot, tamarind, turmeric) and one mixture of spices (curry paste) on iron availability were ... | 2009 | 18651292 |
| new mechanisms and therapeutic potential of curcumin for colorectal cancer. | curcumin is a polyphenol derived from curcuma longa. over the last few years, a number of studies have provided evidence of its main pharmacological properties including chemosensitizing, radiosensitizing, wound healing activities, antimicrobial, antiviral, antifungical, immunomodulatory, antioxidant and anti-inflammatory. more recent data provide interesting insights into the effect of this compound on cancer chemoprevention and chemotherapy. in fact, preclinical studies have shown its ability ... | 2008 | 18655004 |
| curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. | epilepsy is one of the most common serious disorders of the brain. several experimental studies have reported neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. the present study was designed to explore the effect of acute administration of curcumin at doses 50, 100 and 200 mg/kg, orally (p.o.) and its chronic (x 21 days) administration in 100 mg/kg, p.o. on increasing current electroshock (ices) test, elevated plus maze and acto ... | 2008 | 18661468 |
| potential of resveratrol in anticancer and anti-inflammatory therapy. | phytochemicals present in food have shown significant prospects in the treatment and management of a vast array of human diseases. resveratrol is a stilbene-type aromatic phytoalexin predominantly found in grapes, peanuts, berries, turmeric, and other food products. resveratrol has been reported to exhibit several physiological activities including anticancer and anti-inflammatory activities in vitro and in experimental animal models, as well as in humans. anticancer activity of this compound is ... | 2008 | 18667005 |
| ef24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits hif-1. | curcumin, the yellow pigment of the spice turmeric, has emerged as a promising anticancer agent due to its antiproliferative and antiangiogenic properties. however, the molecular mechanism of action of this compound remains a subject of debate. in addition, curcumin's low bioavailability and efficacy profile in vivo further hinders its clinical development. this study focuses on the mechanism of action of ef24, a novel curcumin analog with greater than curcumin biological activity and bioavailab ... | 2008 | 18682687 |
| application of scion image software to the simultaneous determination of curcuminoids in turmeric (curcuma longa). | curcumin, desmethoxycurcumin and bisdesmethoxycurcumin are bioactive constituents of turmeric (curcuma longa). owing to their different potency, quality control of turmeric based on the content of each curcuminoid is more reliable than that based on total curcuminoids. however, to perform such an assay, high-cost instrument is needed. | 2009 | 18683171 |
| differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes. | curcumin (cur) is a major component of a dietary spice derived from the roots of curcuma longa. it has strong antioxidant activities and hepatoprotective properties. primary human hepatocytes are clinically used in transplantation or in bioartificial liver devices for the treatment of patients with liver failure. fresh and cryopreserved hepatocytes are also used in vitro for the study of drugs in pharmacotoxicology. we aimed to assess whether cur could improve human liver cell viability and prev ... | 2008 | 18697189 |
| influence of food acidulants and antioxidant spices on the bioaccessibility of beta-carotene from selected vegetables. | four common food acidulants--amchur, lime, tamarind, and kokum--and two antioxidant spices--turmeric and onion--were examined for their influence on the bioaccessibility of beta-carotene from two fleshy and two leafy vegetables. amchur and lime generally enhanced the bioaccessibility of beta-carotene from these test vegetables in many instances. such an improved bioaccessibility was evident in both raw and heat-processed vegetables. the effect of lime juice was generally more pronounced than tha ... | 2008 | 18729454 |
| antidepressant activity of curcumin: involvement of serotonin and dopamine system. | curcumin is a major active principle of curcuma longa, one of the widely used preparations in the indian system of medicine. it is known for its diverse biological actions. | 2008 | 18766332 |
| curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated i kappab kinase. | curcumin is a natural polyphenolic derogate extracted from spice turmeric, exhibiting anti-inflammatory and chemopreventive activities. it was described to interact with the signalosome-associated kinases and the proteasome-ubiquitin system, which both are involved in the osteoclastogenesis. thus, we hypothesized that curcumin could diminish osteoclast differentiation and function. | 2009 | 18766375 |
| biological activities of curcumin and its analogues (congeners) made by man and mother nature. | curcumin, a yellow pigment present in the indian spice turmeric (associated with curry powder), has been linked with suppression of inflammation; angiogenesis; tumorigenesis; diabetes; diseases of the cardiovascular, pulmonary, and neurological systems, of skin, and of liver; loss of bone and muscle; depression; chronic fatigue; and neuropathic pain. the utility of curcumin is limited by its color, lack of water solubility, and relatively low in vivo bioavailability. because of the multiple ther ... | 2008 | 18775680 |
| in vivo effects of pain relieving plaster on closed soft tissue injury in rabbit ears. | soft tissue injury imposes major public health burdens worldwide. the positive effect of china's tibetan medicine and the lamiophlomis rotata-based herbal pain relieving plaster (prp) on healing closed soft tissue injury (csti) has been reported. the herbs contained in plaster are also referred as 'blood-activating and stasis-dispelling' in herbal medicine. the formula of the plaster contains four china's tibetan medical herbs, including lamiophlomis rotata, oxytropis falcate bunge, curcuma long ... | 2008 | 18793392 |
| curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. | curcumin (diferuloylmethane) is the major active ingredient of turmeric (curcuma longa) used in south asian cuisine for centuries. curcumin has been shown to inhibit the growth of transformed cells and to have a number of potential molecular targets. however, the essential molecular targets of curcumin under physiologic conditions have not been completely defined. herein, we report that the tumor cellular proteasome is most likely an important target of curcumin. nucleophilic susceptibility and ... | 2008 | 18794115 |
| curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor hlj1. | curcumin (diferuloylmethane) is an active component of the spice turmeric and has a diversity of antitumor activities. in this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor dnaj-like heat shock protein 40 (hlj1). human lung adenocarcinoma cells (cl1-5) treated with curcumin (1-20 mumol/l) showed a concentration-dependent reduction in cell migration, invasion, and metastatic ability, and this was associated with increased ... | 2008 | 18794131 |
| the effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats. | in the present study, the effect of chronic oral administration of curcumin in the presence or absence of morphine and noloxone was investigated on the visceral nociception induced by acetic acid in rats. intraperitoneal injection of acetic acid (1 ml, 2%) produced contractions in the abdominal musculature (writhes). the latency time to the beginning of the first writhe was measured and the total number of writhes in the 1 h after acetic acid injection was counted. the latency time to the beginn ... | 2008 | 18817212 |
| neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. | among the naturally occurring compounds, turmeric from the dried rhizome of the plant curcuma longa has long been used extensively as a condiment and a household remedy all over southeast asia. turmeric contains essential oil, yellow pigments (curcuminoids), starch and oleoresin. the present study was designed for investigating the neuroprotective efficacy and the time window for effective therapeutic use of curcuma oil (c. oil). | 2008 | 18826584 |
| comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. | microglia are the resident innate immune cells in the central nervous system. evidence supports that the unregulated activation of microglia results in the production of pro-inflammatory cytokines and chemokines that propagate neuronal injury and finally cause neurodegenerative diseases. curcuminn (cur), demethoxycurcumin (dmc), and bisdemethoxycurcumin (bdmc) are curcuminoid pigments extracted from turmeric (curcuma longa l.). cur has been reported to suppress the activation of microglia by red ... | 2008 | 18838107 |
| anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from porphyromonas gingivalis. | porphyromonas gingivalis, a major periodontopathic bacterium, is necessary for periodontitis to take place. the lipopolysaccharide (lps) of p. gingivalis stimulates cytokine secretion in immune cells, and thereby initiates the inflammation related to periodontitis. macrophages are the important ones of the immune cells that are prominent at inflammatory periodontal sites. curcumin, a major curcumanoid found in the spice turmeric, exhibits anti-inflammatory properties. the aim of this study was t ... | 2008 | 18849645 |
| screening of korean medicinal plants for possible osteoclastogenesis effects in vitro. | bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. bone resorption and loss are generally attributed to osteoclasts. differentiation of osteoclasts is regulated by receptor activator of nuclear factor nf-kb ligand (rankl), a member of tumor necrosis factor family. when the balance is disturbed, pathological bone abnormality ensues. through the screening of traditional korean medicinal plants, the effective molecules for ... | 2008 | 18850234 |
| histological evaluation of curcuma longa-ghee formulation and hyaluronic acid on gingival healing in dog. | the experimental finding of asian traditional medicine revealed the pharmacological effect of the local application of ghee which was taken from cow butterfat and the rhizomes of curcuma longa. these materials significantly improved the healing process of the wound. in addition, ancient physicians of middle east discovered that the powdered rhizomes of curcuma longa (common turmeric) also had impressive medicinal qualities. over the centuries, this spice has been used as a pain relieving, anti-i ... | 2008 | 18929638 |
| inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in alzheimer's disease. | curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share vital pharmacological properties possessed by turmeric, a well known curry spice, considered useful in alzheimer's disease (ad). the aim of this study was to evaluate if curcuminoids possess acetylcholinesterase (ache) inhibitory and memory enhancing activities. the in-vitro and ex-vivo models of ache inhibitory activity were used along with morris water maze test to study the effect on memory in rats. curcumi ... | 2009 | 18930076 |
| in vitro and in vivo studies of the use of some medicinal herbals against the pathogen aeromonas hydrophila in goldfish. | aeromonas hydrophila is a ubiquitous and opportunistic bacterial pathogen that produces ulcerative dermatitis under stress conditions and inflicts severe losses on global fisheries and fish culture. this study evaluates the antimicrobial potency of aqueous and ethanolic decoction (individual extract) and concoction (mixed extract) of three common medicinal herbs, turmeric curcuma longa, tulsi plant ocimum sanctum, and neem azadirachta indica, against the in vitro growth of a. hydrophila. among t ... | 2008 | 18942593 |
| demethoxycurcumin and its semisynthetic analogues as antitubercular agents. | demethoxycurcumin, isolated from the rhizomes of curcuma longa, was found to possess antitubercular activity against mycobacterium tuberculosis h (37)rv strain at 200 microg/ml. derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (mic) value of 7.8 microg/ml. h (37)rv:mycobacterium tuberculosis h (37)rv strain mic:minimum inhibitory concentration. | 2008 | 18991209 |
| anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. | curcumin, a yellow pigment extracted from rhizomes of the plant curcuma longa (turmeric), has been widely used as food additive and also as a herbal medicine throughout asia. the present study was designed to study the pharmacological, biochemical and neurochemical effects of daily administration of curcumin to rats subjected to chronic unpredictable stress. curcumin treatment (20 and 40 mg/kg, i.p., 21 days) significantly reversed the chronic unpredictable stress-induced behavioral (increase im ... | 2009 | 19000708 |
| inhibitory effect of curcumin on the invasion of rat ascites hepatoma cells in vitro and ex vivo. | curcumin, a yellow pigment in turmeric, is a food factor withantioxidative activity. the effect of curcumin on the proliferation and invasion of the rat ascites hepatoma ah109acells was studied in vitro and ex vivo assay systems. especially, a co-culture system of the hepatoma cellswith mesothelial cells derived from rat mesentery was employed to investigate the invasive motility. curcumin suppressed thehepatoma slipping motility in a dose-dependent manner up to 5 mum and thereafter maintained t ... | 2001 | 19003281 |
| an ethnobotanical study of medicinal plants in chandauli district of uttar pradesh, india. | chandauli district is one of the less studied regions of india for its ethnobotanical values. the present paper synthesizes the first report related to the documentation and conservation of ethnomedicinal plants of chandauli district and their socio-economic relationship with the forests and its resources. | 2009 | 19022368 |
| curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. | diabetes exacerbates neuronal injury induced by hyperglycemia mediated oxidative damage and mitochondrial dysfunction. the aim of the present study is to investigate the effects of curcuminoids, polyphenols of curcuma longa (l.) on oxidative stress and mitochondrial impairment in the brain of streptozotocin (stz)-induced diabetic rats. a marked increase in lipid peroxidation and nitrite levels with simultaneous decrease in endogenous antioxidant marker enzymes was observed in the diabetic rat br ... | 2008 | 19031318 |
| inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (curcuma longa). | turmeric has been extensively utilized in indian and chinese medicine for its immune-modulatory properties. dendritic cells (dcs) are antigen-presenting cells specialized to initiate and regulate immunity. the ability of dcs to initiate immunity is linked to their activation status. the effects of turmeric on human dcs have not been studied. here we show that hydroethanolic (hee) but not lipophilic "supercritical" extraction (sce) of turmeric inhibits the activation of human dcs in response to i ... | 2009 | 19034830 |
| curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model. | it is known that curcumin, a dietary pigment from the plant curcuma longa, inhibits cell proliferation and induces apoptosis in different cell lines; however, the therapeutic benefit is hampered by very low absorption after transdermal or oral application. recent studies from our laboratory have demonstrated that curcumin at low concentrations (0.2-1 microg/ml) offered the described effects only when applied with uva or visible light. nevertheless, the in vivo efficacy of this combination is lac ... | 2009 | 19035461 |
| treatment of hiv-associated diarrhea with curcumin. | curcumin is the organic extract of turmeric and possesses known anti-inflammatory properties. our aim was to explore the utility of curcumin in patients with hiv-associated diarrhea. eight patients with hiv-associated diarrhea were given a mean daily dose of 1,862 mg of curcumin and followed for a mean of 41 weeks. all had resolution of diarrhea and normalization of stool quality in a mean time of 13 +/- 9.3 days. mean number of bowel movements per day dropped from 7 +/- 3.6 to 1.7 +/- 0.5. seve ... | 2009 | 19051018 |
| curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells. | hepatic stellate cells (hscs) undergo activation and transdifferentiation to myofibroblast like cells in liver injury, leading to liver fibrosis. during recovery from injury, activated hscs may either revert back to quiescent state or undergo apoptosis or both. in the present study, we have examined whether recovery from hepatic injury involves apoptosis of activated hscs and tested whether curcumin (the yellow pigment from curcuma longa linn.) promotes recovery from hepatic injury by inducing a ... | 2008 | 19069843 |
| curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the janus-activated kinase-protein kinase cdelta-stat1 signaling pathway in interferon-gamma-stimulated murine dendritic cells. | indoleamine 2,3-dioxygenase (ido) catalyzes the initial and rate-limiting step in the degradation of tryptophan and is strongly induced in interferon-gamma (ifngamma)-stimulated dendritic cells (dcs). ido has recently been established as a key enzyme in t-cell suppression-mediated immune tolerance to tumors. stat1 phosphorylation appears to play an important role in the control of ido expression by ifngamma, but the precise regulatory mechanism remains obscure. here we present a novel mechanism ... | 2009 | 19075017 |
| [comparison and correlative analysis of trace elements in five kinds of radix curcumae]. | traditional chinese medicine materials (tcm) contained abundant trace elements needed in human body. mixed acid (hno3:hclo4) was added into samples treated by microwave digestion, and a systematic study was carried out by selection of the most appropriate working conditions and optimization of the sample mass. some inorganic elements in 5 kinds of radix curcumae (curcuma wenyujin y. h. chen et c. ling, curcuma longa l., curcuma kwangsiensis s. g. lee et c. f. liang, curcuma phaeocaulis val. and ... | 2008 | 19093592 |
| curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by stat-3 signaling. | curcumin (from the rhizome of curcuma longa) is well documented for its medicinal properties in indian and chinese systems of medicine where it is widely used for the treatment of several diseases. epidemiological observations are suggestive that curcumin consumption may reduce the risk of some form of cancers and provide other protective biological effects in humans. these biological properties have been attributed to curcuminoids that have been widely studied for their anti-inflammatory, anti- ... | 2008 | 19116450 |
| involvement of na(+)-ca (2+) exchanger in the endothelium-independent vasorelaxation induced by curcuma longa l. in isolated rat superior mesenteric arteries. | previous studies confirmed that the methanolic extract from curcuma longa l. (clme) lowers arterial blood pressure and heart rate in rats due to the blockade of extracellular ca(2+) influx. the aim of this study was to investigate the involvement of na(+)-ca (2+) exchanger in the vasorelaxant effects elicited by clme in isolated rat superior mesenteric arteries. clme (1-1,000 microg/ml) concentration-dependently relaxed phenylephrine (phe) (10 microm) pre-contracted arterial rings with intact-en ... | 2008 | 19122379 |
| epidemiology of animal bites and rabies cases in india. a multicentric study. | rabies, a disease of antiquity continues to be a major public health problem in india. multiple factors contribute to high mortality and morbidity due to animal bites. an effective strategy for control of rabies takes into account the epidemiology of animal bites, rabies and factors influencing post exposure treatment. the study was carried out as a part of agreement for performance of work (apw) from world health organization (who) during the period april 2001 to september 2002. two sets of pro ... | 2008 | 19127666 |
| molecular orbital basis for yellow curry spice curcumin's prevention of alzheimer's disease. | it is demonstrated by using high-level ab initio computations that the yellow curcumin pigment, bis-(4-hydroxy-3-methoxyphenyl)-1,6-diene-3,5-dione, in the east indian root plant turmeric (curcuma longa) exhibits unique charge and bonding characteristics that facilitate penetration into the blood-brain barrier and binding to amyloid beta (abeta). alzheimer's disease is caused by abeta accumulation in the brain cells combined with oxidative stress and inflammation. consistent with the recent expe ... | 2006 | 19127718 |
| a poly-herbal formulation accelerates normal and impaired diabetic wound healing. | in the present study, a poly-herbal formulation (phf) was prepared by combining the aqueous lyophilized leaf extracts of hippophae rhamnoides l. and aloe vera l. and the ethanol rhizome extract of curcuma longa l., in an optimized ratio (1 : 7 : 1). the efficacy of phf treatment was studied in normal and impaired diabetic rats using a full-thickness cutaneous wound model. topical phf treatment increased cellular proliferation and collagen synthesis at the wound site in normal rats, as evidenced ... | 2008 | 19128249 |
| modulation of ovine neutrophil function and apoptosis by standardized extracts of echinacea angustifolia, butea frondosa and curcuma longa. | impaired neutrophil function has been associated with increased infectious diseases in ruminants. attachment of neutrophils to endothelium and superoxide production is critical features of their immune activity. once the infection is cleared, programmed cell death ensures the rapid resolution of inflammation. to develop new natural therapeutics for ruminants, standard extracts of echinacea angustifolia (polinacea), butea frondosa and curcuma longa (curcuvet) were first evaluated on ovine neutrop ... | 2009 | 19128841 |
| study of curcumin and genistein interactions with human serum albumin. | curcumin, the yellow pigment from the rhizoma of curcuma longa, is a widely studied polyphenolic compound which has a variety of biological activity as anti-inflammatory and antioxidative agent. genistein one of the flavonoids found in soybean and chickpeas inhibits dna strand breaks acting as a direct scavenger of reactive oxygen species. human serum albumin (hsa) with high affinity binding sites is a major transporter for delivering several endogenous compounds and drugs in vivo. the aim of th ... | 2009 | 19135819 |
| potential effect of curcuma longa extract on infectivity and pathogenicity of schistosoma mansoni cercariae. | batch of freshly shed cercariae from infected laboratory bred biomphalaria alexandrina were exposed to different sub-lethal concentrations of turmeric extract for an hour and divided into two groups. the first one was to study the ultrastructural changes induced in them using scanning electron microscopy (sem). the second group was to study infectivity and pathogenicity of the exposed cercariae. one hundred and fifty mice were divided into 5 groups: gi: infected by normal cercariae and served as ... | 2008 | 19143127 |
| study on antifibrotic effects of curcumin in rat hepatic stellate cells. | suppression of activation or fibrogenesis and induction of apoptosis, in hepatic stellate cells (hscs) have been proposed as therapeutic strategies against liver fibrosis. curcumin, an active compound isolated from yellow curry pigment of turmeric (curcuma longa linn), has been demonstrated to be an effective anti-inflammatory and antioxidant compound. in this study, we investigated the in vitro antifibrogenic effects of curcumin on hscs at the concentration range of (1-40 microm). a cell line o ... | 2009 | 19152370 |
| curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (fe-nta): implications for cancer prevention. | curcumin (diferuloylmethane), a biologically active ingredient derived from rhizome of the plant curcuma longa, has potent anticancer properties as demonstrated in a plethora of human cancer cell lines/animal carcinogenesis model and also acts as a biological response modifier in various disorders. we have reported previously that dietary supplementation of curcumin suppresses renal ornithine decarboxylase (okazaki et al. biochim biophys acta 1740:357-366, 2005) and enhances activities of antiox ... | 2009 | 19165575 |
| curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. | curcumin, a yellow pigment obtained from turmeric (curcumina longa), is a dietary polyphenol that has been reported to possess anti-inflammatory and antioxidant properties. the effect of curcumin against the development of pulmonary emphysema in animal models is unknown. the aim of this study was to determine whether curcumin is able to attenuate the development of pulmonary emphysema in mice. nine-week-old male c57bl/6j mice were treated with intratracheal porcine pancreatic elastase (ppe) or e ... | 2009 | 19168576 |
| curcumin disrupts the mammalian target of rapamycin-raptor complex. | curcumin (diferuloylmethane), a polyphenol natural product of the plant curcuma longa, is undergoing early clinical trials as a novel anticancer agent. however, the anticancer mechanism of curcumin remains to be elucidated. recently, we have shown that curcumin inhibits phosphorylation of p70 s6 kinase 1 (s6k1) and eukaryotic initiation factor 4e (eif4e) binding protein 1 (4e-bp1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mtorc1) in numerous cancer cell l ... | 2009 | 19176385 |
| effects of curcumin on n-bis(2-hydroxypropyl) nitrosamine (dhpn)-induced lung and liver tumorigenesis in balb/c mice in vivo. | curcumin (diferuloylmethane), a phenolic compound from the plant curcuma longa (linn.) has been shown to exhibit antitumor activity and apoptosis in many human cancer cell lines including that of lung and liver cancer. in this study, curcumin was evaluated in balb/c mice for its ability to inhibit pulmonary and liver adenoma formation and growth after they were orally treated with n-bis(2-hydroxypropyl)nitrosamine (dhpn). animals were treated with dhpn in water for approximately 14 days before m ... | 2008 | 19181006 |
| interaction of tea catechin (-)-epigallocatechin gallate with lipid bilayers. | a major component of green tea extracts, catechin (-)-epigallocatechin gallate (egcg), has been reported to be biologically active and interacting with membranes. a recent study reported drastic effects of egcg on giant unilamellar vesicles (guvs). in particular, egcg above 30 microm caused guvs to burst. here we investigated the effect of egcg on single guvs at lower concentrations, believing that its molecular mechanism would be more clearly revealed. we used the micropipette aspiration method ... | 2009 | 19186140 |
| comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system. | the antiulcer effect of bisdemethoxycurcumin, a yellow pigment found mainly in rhizomes of curcuma longa, was compared with curcumin in gastric ulcer model systems to validate its clinical application as a remedy for peptic ulcer. western blot analysis of mouse macrophage cell line raw 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (inos) production significantly but had no effect on tumor necrosis factor-alpha (tnf-alpha) produ ... | 2009 | 19188055 |
| molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. | cervical cancer is the most common cancer in indian females and is associated with infection with high risk human papillomaviruses (hpvs). curcumin (diferuloyl methane), a chemopreventive agent, is a natural compound extracted from curcuma longa that allows suppression of carcinogenesis. the objective of this study was to identify the molecular mechanism of curcumin induced apoptosis in hpv positive cervical cancer hela, siha and ca ski cells. curcumin causes distinct inhibition of human telomer ... | 2009 | 19191010 |
| a simple 2-directional high-performance thin-layer chromatographic method for the simultaneous determination of curcumin, metanil yellow, and sudan dyes in turmeric, chili, and curry powders. | a method using simple extraction and 2-directional high-performance thin-layer chromatography (hptlc) was developed for the simultaneous determination of curcumin, metanil yellow, and sudan dyes in turmeric, chili, and various mixed curry powder formulations. the method offers resolution (rf) of turmeric pigments, namely, curcumin (0.77), demethoxycurcumin (0.69), bis(demethoxy)curcumin (0.61), and the synthetic dye metanil yellow (0.05) by the first-directional mobile phase, chloroform-methanol ... | 2008 | 19202799 |
| antimicrobial activity of curcumin against helicobacter pylori isolates from india and during infections in mice. | treatment failure is a major cause of concern for the helicobacter pylori-related gastroduodenal diseases like gastritis, peptic ulcer, and gastric cancer. curcumin, diferuloylmethane from turmeric, has recently been shown to arrest h. pylori growth. the antibacterial activity of curcumin against 65 clinical isolates of h. pylori in vitro and during protection against h. pylori infection in vivo was examined. the mic of curcumin ranges from 5 microg/ml to 50 microg/ml, showing its effectiveness ... | 2009 | 19204190 |
| two methods for attenuating toxoplasma gondii tachyzoites rh strain by using ethanol extract of curcuma longa. | the ethanol extract of curcuma longa proved to be an attenuated agent against toxoplasma gondii (rh strain) tachyzoites in the mice peritoneal fluid by two incubation methods. groups of female mice were injected by attenuated tachyzoites as 200 tachyzoites / ml, which treated with the ethanol extract of curcuma longa was previously treated. the result was observed after one week, as no tachyzoites were found in the peritoneal fluid of the experimental infected mice. | 2008 | 19209778 |
| curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia b cells and may overcome their stromal protection in combination with egcg. | chronic lymphocytic leukemia (cll) is incurable with current chemotherapy treatments. curcumin (diferuloylmethane), an active ingredient in the spice turmeric, inhibits tumor metastasis, invasion, and angiogenesis in tumor cell lines. we evaluated the effects of curcumin on the viability of primary cll b cells and its ability to overcome stromal mediated protection. | 2009 | 19228728 |
| the protective role of curcumin in cardiovascular diseases. | curcumin (diferuloylmethane) is a polyphenol responsible for the yellow color of the curry spice turmeric. it has been used in a variety of diseases in traditional medicine. modern scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-thrombotic, and cardiovascular protective effects. in this review, we focused mainly on the effects of curcumin on the cardiovascular system. the antioxidant effects of curcumin have been shown to attenuate adriamycin-ind ... | 2009 | 19233493 |
| immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni. | curcumin is a polyphenol derived from the dietary spice turmeric. it has been shown to regulate numerous transcription factors, cytokines, adhesion molecules, and enzymes that have been linked to inflammation. in addition to inhibiting the growth of a variety of pathogens, curcumin has been shown to have nematocidal activity. the present study was designed to evaluate the schistosomicidal activity of curcumin in vivo as well as immunomodulation of granulomatous inflammation and liver pathology i ... | 2009 | 19249123 |
| activation of apoptotic protein in u937 cells by a component of turmeric oil. | aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. this study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma u937 cells. ar-turmerone treatment inhibited u937 cell viability in a concentration-dependent fashion, with inhibition exceeding 84%. moreover, the treatment produced nucleosomal dna fragmentation and the percentage of sub-diploid cells increased in a concentration-dependent manner; ... | 2009 | 19250610 |
| pharmacokinetics prediction and drugability assessment of diphenylheptanoids from turmeric (curcuma longa l). | cheminformatics approaches are currently not employed in any of the spices to study the medicinal properties traditionally attributed to them. the aim of this study is to find the most efficacious molecule which do not have toxic effects but at the same time have desired pharmacokinetic profile. in the present study of the class 'diphenylheptanoids' from turmeric, cheminformatics methods were employed to predict properties such as physicochemical properties, absorption, distribution, metabolism, ... | 2009 | 19275711 |
| further examination of antiradical properties of crocus sativus stigmas extract rich in crocins. | data for antiradical properties of saffron extract and its bioactive constituents (crocins, crocetin) are limited and poorly discussed in comparison with those of extracts containing potent scavengers. further examination was sought using the folin-ciocalteu (f-c) reagent and various free radical species produced in cell-free or cell model systems. oregano and turmeric methanol extracts, rich in well established scavengers, and also crocetin, rosmarinic acid, and curcumin, representing the major ... | 2009 | 19284715 |
| prophylactic role of curcumin in dextran sulfate sodium (dss)-induced ulcerative colitis murine model. | we have addressed in this study the possible protective role of the main principle of turmeric pigment; curcumin on a murine model of ulcerative colitis (uc). colitis was induced by administration of dextran sulfate sodium (dss) (3% w/v) in drinking water to male swiss albino rats for 5 consecutive days. dss challenge induced uc model that was well characterized morphologically and biochemically. dss produced shrinkage of colon length and increased the relative colon weight/length ratio accompan ... | 2009 | 19285535 |
| curcumin inhibits proliferation and migration by increasing the bax to bcl-2 ratio and decreasing nf-kappabp65 expression in breast cancer mda-mb-231 cells. | curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), is extracted from the plant curcuma longa. it has cytotoxic effects and induces apoptosis in many human cancer cells but the molecular mechanisms are not fully understood. in the present study, we evaluated the effects of curcumin on human breast cancer mda-mb-231 cells. the cytotoxic effects of curcumin on mda-mb-231 cells were measured by mtt assay. the percentages of cell cycle were determined by flow cytometry. the prote ... | 2009 | 19288022 |
| curcumin inhibits adipogenesis in 3t3-l1 adipocytes and angiogenesis and obesity in c57/bl mice. | angiogenesis is necessary for the growth of adipose tissue. dietary polyphenols may suppress growth of adipose tissue through their antiangiogenic activity and by modulating adipocyte metabolism. we investigated the effect of curcumin, the major polyphenol in turmeric spice, on angiogenesis, adipogenesis, differentiation, apoptosis, and gene expression involved in lipid and energy metabolism in 3t3-l1 adipocyte in cell culture systems and on body weight gain and adiposity in mice fed a high-fat ... | 2009 | 19297423 |
| curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling. | nonalcoholic steatohepatitis (nash) is commonly found in patients with obesity and is often accompanied with abnormally elevated levels of plasma leptin, i.e. hyperleptinemia. a relatively high population of nash patients develops hepatic fibrosis, even cirrhosis. hepatic stellate cells (hscs) are the major effector cells during liver fibrogenesis and could be activated by leptin. the antioxidant curcumin, a phytochemical from turmeric, has been shown to suppress hsc activation in vitro and in v ... | 2009 | 19299451 |
| antidepressant-like effects of curcumin on serotonergic receptor-coupled ac-camp pathway in chronic unpredictable mild stress of rats. | serotonergic receptors take their physiologic effects by affecting adenylyl cyclase (ac) catalytic activity and cyclic adenosine monophosphate (camp) concentration. ac-camp second messenger pathway has been recently suggested to play an important role in depression. therefore, the compound that regulates the signal pathway may have potential as antidepressant. curcumin is the main component of curcuma longa l, a well-known indigenous herb with comprehensive bioactivities. in the present study, w ... | 2009 | 19302828 |
| modulation of in vitro murine b-lymphocyte response by curcumin. | curcumin is a phenolic natural product isolated from the rhizome of curcuma longa (tumeric). it was previously described that curcumin had a potent anti-inflammatory effect and inhibited the proliferation of a variety of tumor cells. in the present study, we investigated the inhibitory effects of curcumin on the response of normal murine splenic b cells. curcumin inhibited the proliferative response of purified splenic b cells from balb/c mice stimulated with the toll-like receptor ligands lps a ... | 2009 | 19303754 |
| tea polyphenols and their roles in cancer prevention and chemotherapy. | many plant-derived, dietary polyphenols have been studied for their chemopreventive and chemotherapeutic properties against human cancers, including green tea polyphenols, genistein (found in soy), apigenin (celery, parsley), luteolin (broccoli), quercetin (onions), kaempferol (broccoli, grapefruits), curcumin (turmeric), etc. the more we understand their involved molecular mechanisms and cellular targets, the better we could utilize these "natural gifts" for the prevention and treatment of huma ... | 2008 | 19325799 |