Publications

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enzymatic studies on the exsheathment of haemonchus contortus infective larvae: the role of leucine aminopeptidase. 19725075761
disease-producing capacity of haemonchus contortus isolates in sheep. 19725081482
seasonal change in a balanced polymorphism in haemonchus contortus populations. 19715102452
morphological characterizatioon of the stage of arrested development of haemonchus contortus in sheep. 19715118671
effect of concurrent and terminated infections of haemonchus contortus on the development and reproductive capacity of nematodirus battus. 19715135638
the lactic acid dehydrogenases of some parasitic gastro-intestinal nematodes: ascaris suum, oesophagostomum radiatum and haemonchus contortus. 19715137637
density dependence of the weight of haemonchus contortus adults. 19715156170
haemonchus contortus: genetically determined polymorphism in females. 19715157769
cyanocobalamin (vit. b 12 ) absorption in normal and haemonchus contortus infested sheep. 19715161391
plasma and blood volume changes in sheep experimentally infested with haemonchus contortus. 19715161395
fecal egg output of lambs in relationship to haemonchus contortus burden. 19715170631
effects of haemonchus contortus inoculation on growth rate, feed efficiency and hematology of feeder lambs. 19695189752
the accidental occurrence of haemonchus contortus cobb, 1898 (trichostrongylidae, nematoda) in the stomach of wallago attu. 19665299054
gel filtration and disc electrophoresis of a somatic extract and excretions and secretions of haemonchus contortus larvae. 19695362575
the dynamics of the host-parasite relationship. vii. the effect of discontinuity of infection onesistance to haemonchus contortus in sheep. 19695374703
the use of clioxanide as an anthelmintic in sheep infected with haemonchus contortus. 19695389344
the fate of very large doses of haemonchus contortus and their effect on conditions in the ovine abomasum. 19705417934
effects of heat and lugol's iodine on the evaluation of ecdysis of infective haemonchus contortus cayugensis larvae. 19705420439
strains of haemonchus contortus resistant against benzimidazole anthelmintics. 19705442447
the development of haemonchus contortus in vitro. ii. the effect of disulphide-reducing and sulphydryl-blocking reagents on the rate of development to the fourth-stage larvae. 19705443872
comparative response of two ovine isolates of haemonchus contortus to thiabendazole. 19705466489
clioxanide, a new anthelmintic active against fasciola hepatica and haemonchus contortus in sheep. 19705481928
the inhibitory effect of co2 on the ecdysis of infective haemonchus contortus cayugensis larvae. 19705483915
the influence of pco2 and the rate of shaking on the ecdysis of infective haemonchus contortus cayugensis larvae. 19705483916
the effects of larval age and cold storage on the ecdysis of infective haemonchus contortus cayugensis larvae. 19705483917
the efficacy of rafoxanide (3,5-diiodo-3'-chloro-4'-(p-chlorophenoxy) salicylanilide) against haemonchus contortus in sheep. 19705499325
the response to desiccation of eggs of trichostrongylus colubriformis and haemonchus contortus (nematoda: trichostrongylidae). 19705530099
the anthelmintic efficiency of clioxanide and rafoxanide against fasciola hepatica and haemonchus contortus in sheep. 19715542375
haemonchus contortus infection in sheep: active and passive immunity in sheep given oral iron supplement. 19715545464
further analyses of supernatant fluids from exsheathing infective haemonchus contortus cayugensis larvae. 19715568345
the seasonal incidence of inhibition of development in haemonchus contortus. 19715575482
a controlled test of methyridine, thiabendazole and parbendazole against haemonchus contortus and trichostrongylus colubriformis in lambs. 19715580379
modified cilia in sensory organs of juvenile stages of a parasitic nematode.electron microscopical studies revealed the presence of dendritic nerve processes in sensory organs of the third- and fourth-stage juveniles of haemonchus contortus, which contained structures resembling modified cilia. with few exceptions, the outer circle of fibers consisted of ten doublets, and in place of typical cilia-like central fibers were small microtubules or vesicles varying in number from zero to five.19675611021
strain variation in the response of haemonchus contortus in sheep and goats given phenothiazine: efficacy of n. f. and purified products on pure parasitic infections. 19675624592
field trials on the efficacy of thiabendazole against haemonchus contortus in west african dwarf forest sheep and goats. 19675629277
susceptibility of chinchilla spp. to haemonchus contortus. 19685641043
utilization of tricarboxylic acid cycle intermediates by haemonchus contortus larvae. 19685651294
pyruvate kinase in haemonchus contortus larvae. 19685651300
first parasitic ecdysis of haemonchus contortus in vitro without stimulation by carbon dioxide. 19685652499
the occurrence of strains of haemonchus contortus resistant to thiabendazole. 19685689434
desiccation survival of the infective larva of haemonchus contortus. 19685697836
neurosecretory granules in the infective stage of haemonchus contortus. 19685740548
spring rise phenomenon in ovine helminthiasis. ii. in stabled ewes experimentally infected with haemonchus contortus. 19685750262
carbon dioxide fixation in haemonchus contortus larvae. 19685758884
the development of haemonchus contortus in vitro. i. the effect of ph and pco2 on the rate of development to the fourth-stage larva. 19695769494
influence of ph on uptake of thiabendazole by the nematode haemonchus contortus. 19695792783
evaluation of naphthalophos against oestrus ovis and a thiabendazole-tolerant strain of haemonchus contortus in lambs. 19695812440
changes in sex ratio in haemonchus contortus cayugensis. 19695815823
the effect of time and season on the constancy of morph in haemonchus contortus cayugensis infections. 19695815824
relationship of the host's diet to the parasitic development of haemonchus contortus. 19695815927
hemoglobin types and resistance to haemonchus contortus in sheep. 19695824905
reactions of two populations of haemonchus contortus to continual low dosages of phenothiazine of varying purity and particle size in sheep. 19655894162
light sense in nematodes.the stimulating effect of daylight on the oxygen uptake of the infective larvae of haemonchus contortus and nippostrongylus basiliensis, measured at constant temperature, provides the first proof of a dermal light sense in the nematoda. nippostrongylus larvae are less sensitive than those of haemonchus and require very high light intensities before a significant effect can be detected.19665903341
the development of haemonchus contortus to the fourth stage in vitro. 19665910446
development of haemonchus contortus in media designed for studies on caenorhabditis briggsae. 19665910447
studies on evaluation of low-level administration of phenothiazine in selection of drug-resistant haemonchus contortus. 19665948718
studies on blood picture in stomachworm (haemonchus contortus and haemonchus bispinosus mixed infection) infection in sheep and goats. 19665949912
susceptibility of the offspring of haemonchus contortus surviving low-level phenothiazine treatment to single dosees of phenothiazine and thiabendazole. 19665950158
activity of a series of piperidines against haemonchus contortus larvae. 19665968022
acquired resistance to haemonchus contortus in young lambs. 19666006081
pathological changes and vitamin b12 metabolism in sheep parasitised by haemonchus contortus, ostertagia spp. and trichostrongylus colubriformis. 19666006735
studies on immunity to haemonchus contortus infection: the elimination of a challenge infection by immune sheep. 19666008291
the dynamics of the host-parasite relationship. iv. the response of sheep to graded and to repeated infection with haemonchus contortus. 19666008292
the dynamics of the host-parasite relationship. v. evidence for immunological exhaustion in sheep experimentally infected with haemonchus contortus. 19666008293
the vulval flap formula of haemonchus contortus from sheep in south-east england. 19666008304
immunity to haemonchus contortus infection. failure of x-irradiated larvae to immunize young lambs. 19666008310
immunity to haemonchus contortus infection: relationship between age and successful vaccination with irradiated larvae. 19666008311
critical trials with tetramisole given to lambs experimentally infected with haemonchus contortus, ostertagia circumcincta, nematodirus battus and trichostrongylus colubriformis. 19666008430
glycolysis in haemonchus contortus larvae and rat liver. 19676049998
the seven-day growth of haemonchus contortus compared in worm-free and experienced sheep. 19676067678
comparison between copper-arsenic-piperazine and haloxon-piperazine drenches for treatment of haemonchus contortus and oesophagostomum columbianum in sheep. 19676067862
differential hatching of eggs from morph variants of haemonchus contortus cayugensis (nematoda, trichostrongylidae). 19676068135
comparative activity and intracellular distribution of tricarboxylic acid cycle enzymes in haemonchus contortus larvae and rat liver. 19676080499
amino acid biosynthesis in haemonchus contortus from c14-labelled precursors, in vitro.adult haemonchus contortus (nematoda: trichostrongylidae) was investigated for its ability to utilize various c14-labelled precursors, i.e., glucose, acetate, co2 and palmitic acid, for amino acid biosynthesis. h. contortus has been demonstrated to be capable of synthesizing essential as well as non-essential amino acids. label from all the precursors was detected in aspartic acid, lysine, histidine, cystine, cysteine, glutamic acid, proline, arginine, tyrosine, alanine, glycine, serine, valine, ...19846093333
therapeutic and prophylactic efficacy of morantel when administered directly into the rumen of cattle on a continuous basis.the efficacy of morantel tartrate when administered on a continuous basis directly into the rumen/reticulum of cattle, either by a cannula or from a specially designed device, was evaluated against gastrointestinal parasites under laboratory conditions. in two experiments the continuous infusion of morantel at rates between 0.26 and 1.04 mg/kg body weight per day using a peristaltic pump was highly efficacious in both preventing the establishment of infections and removing established infections ...19836225238
the helminths of various antelope species from natal.helminth parasites were collected from 2 bushbuck, tragelaphus scriptus, 2 red duiker, cephalophus natalensis, 1 oribi, ourebia ourebi, and 4 reedbuck, redunca arundinum, that died or were culled in various parts of natal. one trematode genus, 1 cestode genus and 12 nematode species were recovered. haemonchus contortus. ostertagia harrisi, trichostrongylus capricola, trichostrongylus vitrinus, cooperia rotundispiculum and setaria scalprum are new parasite records for the red duiker. trichostrong ...19846241958
effect of ph and temperature on four dehydrogenase enzymes of haemonchus contortus. 19846242277
changes in water content and volume accompanying exsheathment of haemonchus contortus. 19826279531
anthelmintic efficacy of mebendazole suspension against induced helminth infections in south african sheep and cattle.critical controlled tests were performed in 157 sheep (8 experiments) and 34 cattle (2 experiments) to evaluate the anthelmintic activity of mebendazole suspension, administered intraruminally via a stomach tube at a dosage rate of 15 mg of mebendazole/kg of body weight, against induced infections of immature and adult stages of commonly encountered nematode parasites in south africa. in the sheep, the controlled efficacy of mebendazole suspension was good to excellent (90.1% to 100%) against al ...19846375485
reversal of order of ecdysis in haemonchus contortus (nematoda).exposure of haemonchus contortus infective larvae to carbon dioxide under specific conditions is believed to activate a succession of events that ultimately control both exsheathment and subsequent development to the fourth stage. rarely at ph 6, but always at ph 2, worms fail to exsheath yet develop to the fourth stage surrounded by cuticles two and three. failure to exsheath is probably a consequence of inactive enzymes in exsheathing fluid, because exposure to edta, which inactivates exsheath ...19836406659
partial biochemical and serological characterization of exsheathing fluid and somatic extracts of infective larvae and adult females of haemonchus contortus.exsheathing fluid from infective larvae of haemonchus contortus may contain antigens which induce protective immunity upon infection in sheep. in this study, a rapid method of preparing exsheathing fluid was used to determine its biological activity, purity and antigenic complexity. protein in exsheathing fluid ranged from 21-59.5 micrograms/ml and no carbohydrate was detected. gel filtration showed a single broad peak which retained biological activity and polyacrylamide gel electrophoresis dem ...19846426763
energy metabolism of adult haemonchus contortus in vitro: a comparison of benzimidazole-susceptible and -resistant strains.in vitro biochemical characteristics of three strains of haemonchus contortus, benzimidazole-susceptible, mebendazole-resistant and thiabendazole-resistant isolates, were investigated. steady-state pool sizes of glucose and metabolic intermediates, including adenine nucleotides and end-products revealed no differences between adult worms resistant or susceptible to benzimidazoles in 30-60 min incubations. possible regulatory steps in the glycolytic pathway are identified as those involving the e ...19846427605
studies on haemonchus contortus. ix. the effect of trichostrongylus axei in merinos on natural pasture.four groups of 6-7-month-old merino lambs were each dosed with 40 000 infective larvae of trichostrongylus axei on 2 november 1976 and subsequently exposed to challenge with haemonchus contortus on natural grazing at the university of pretoria's experimental farm in the eastern suburbs of pretoria. one of these groups and one group of controls were killed every 8 weeks from the end of december 1976-june 1977. predosing with t. axei was greater than 50% effective against 5th stage and adult h. co ...19846462631
studies on haemonchus contortus. x. the effect of trichostrongylus axei in merinos on artificial pastures.a recently established eragrostis curvula pasture 1,1 ha in size at hennops river in the transvaal highveld was contaminated from 6 october 1976 until 20 may 1977 by 30 weaned merinos, each infested with 7 000 infective larvae of h. contortus. on 2 november 1976 3 groups of weaned merinos and again on 10 january 1977 a further group of merinos were infested with 40 000 infective larvae of trichostrongylus axei. from 19 november a single group of sheep, predosed with t. axei, and a control group ...19846462632
studies on haemonchus contortus. xi. the effect of a bovine strain of trichostrongylus axei in merinos on natural pastures heavily infested with h. contortus.sheep grazed on natural pastures heavily infested with infective larvae of haemonchus contortus. sixty-eight weaned merinos were divided into 6 groups on day 0 (23 november 1977), and on day +14 (7 december) 79 merinos were divided into 7 groups. there were 2 groups of undosed controls and other groups were either dosed with infective larvae of trichostrongylus axei (bovine strain) only on days 0 and +14, or in combination with h. contortus, or with subsequent doses of h. contortus, 28 days late ...19846462634
studies on haemonchus contortus. xii. effect of trichostrongylus axei in dorper lambs on natural pasture lightly infested with h. contortus.weaned dorper lambs on natural pasture were predosed with 40 000 infective larvae (l3) of trichostrongylus axei, irradiated (0,3 kgy) l3 of t. axei or closantel at 10 mg/kg either in september or november 1978 and were compared with merino yearlings predosed with 40 000 l3 of t. axei in november 1977. the following summer (december-march) only 178,6 mm of rain fell and very few h. contortus were present on pastures. artificial challenge with 20 000 l3 of haemonchus contortus with the local strai ...19846462635
effect of cimetidine on abomasal ph and haemonchus and ostertagia species in sheep.cimetidine, a histamine h2-receptor blocking agent which reduces gastric acid flow in simple stomach animals was administered directly into the abomasum of sheep at 100 mg kg-1 twice daily for five consecutive days and again on the eighth day. the drug caused a significant increase in the ph values of the abomasal contents and was highly effective in reducing the adult population of haemonchus contortus (100 per cent) and ostertagia circumcincta (70 per cent) in the abomasum of sheep. the possib ...19846463375
prevalence of anthelmintic resistant nematodes in sheep in south-east england.the prevalence of anthelmintic resistant nematodes among 52 commercial flocks in south-east england was investigated by comparing the faecal egg counts of groups of lambs before, and seven days after, treatment with thiabendazole and levamisole. evidence of thiabendazole resistance was found on seven farms. in each case haemonchus contortus was the only species of nematode involved. in vitro egg hatch assays carried out for isolates from these farms gave ed50 estimates of 0.065 to 0.332 microgra ...19846464318
the effect of anaerobiosis on adenosine triphosphate levels in larval nippostrongylus brasiliensis and haemonchus contortus.the adenosine triphosphate (atp) content of the pre-parasitic stages of nippostrongylus brasiliensis, haemonchus contortus (l1, l2 and l3) and the adults of the free-living nematode, panagrellus redivivus, have been measured by bioluminescent photometry in aerated or near-anoxic conditions. the atp content of the l1 and l2 stages of both parasitic species was unaltered by a lack of oxygen over a 90-min period. however, the l3 stage of both species and the adults of p. redivivus showed a signific ...19846506845
studies on the pathophysiology of chronic ovine haemonchosis in merino and scottish blackface lambs.an experiment was conducted to examine, under laboratory conditions, the pathophysiology of chronic ovine haemonchosis. in the present study, groups of merino and scottish blackface lambs were maintained on a low plane of nutrition and infected with 50 haemonchus contortus larvae/kg live weight. the parasitized lambs along with respective breed controls were examined over a 27-week period. in addition to the body weight, haematological and parasitological parameters, erythrokinetic, metabolic, d ...19846514383
the effect of transfer factor treatment on two challenge infections of haemonchus contortus in immuno-competent 7-month-old lambs.a number of immuno-competent blackface lambs were infected with 10,000 haemonchus contortus third stage larvae and were later challenged with a second dose of 10,000 h. contortus third stage larvae. one group of lambs was treated with dialysed transfer factor prior to the second challenge dose. histological changes in the abomasal wall, reductions in abomasal worm burdens at slaughter and faecal egg counts monitored throughout the experiment suggested the presence in some animals of an innate re ...19846516210
stocking rate effects on the worm burdens of angora goats and merino sheep.worm egg counts of yearling angora or merino wethers grazing in mixed flocks at either 4/ha or 8/ha were observed over a 5 month period. based on faecal egg counts infection levels in the sheep increased for the first 3 months and then decreased as the animals developed resistance. egg counts in the goats did not decrease during the experiment. post mortem worm counts indicated that there was a significant host species--stocking rate interaction on worm burdens of haemonchus contortus adults and ...19846517775
the structure of excretory system of the infective larva of haemonchus contortus. 19846526575
effects of bovine heme on development of haemonchus contortus in vitro. 19846527196
[kinetics of the population of worms in various developmental stages, haemonchus contortus in sheep after a single experimental infection] experimental infection].this work was performed to study, in 147 month-old male lambs experimentally infected with 14000 haemonchus contortus infective larvae and slaughtered at 6, 12, 18 and 24h and at 2, 6, 8, 11, 15 and 39 days post-infection (pi): 1, the importance, localisation and nature (with or without sheath) of the worms during the first 24 h pi; 2, the kinetics of the total worm population and of each evolutionary stages from the first to the 39th day pi: 3, the period of emergence of the fourth-stage larvae ...19846529116
the anthelmintic efficacy of d.l. tetramisole against haemonchus contortus infection in goats. 19846531494
serum and abomasal antibody response of sheep to infections with haemonchus contortus.serum and abomasal iga, igg and igm antibody response against adult worm, l3 and egg antigens of haemonchus contortus was monitored by the elisa technique after one or two infections with this nematode. following the first infection, antibody levels in serum did not change materially. after administration of a challenge dose of infective larvae, antibodies of the three immunoglobulin classes in infected animals rose slightly, but this rise appeared later than the fall in the faecal egg counts. i ...19846538719
wool production of sheep chronically infected with haemonchus contortus.a chronic infection was established in a group of twenty 18-month-old non-reproductive merino ewes by oral administration of 3000 infective h. contortus larvae twice weekly for 12 weeks. their live-weights and wool production were compared with those of 20 uninfected ewes grazing the same pasture. in the infected sheep, faecal egg counts increased over a period of 9 weeks to reach a mean of 5000 eggs per gram, accompanied by small, but significant effects on packed-cell volume and live-weight. t ...19846541834
resistance to haemonchus contortus transferred between genetically histocompatible sheep by immune lymphocytes.the pattern of faecal egg counts after infection with 10,000 haemonchus contortus larvae was similar within but not between, four pairs of monozygous twin sheep. transfer of whole lymph or washed lymph cells from three immune donor sheep to their identical co-twin recipients reduced the susceptibility of the recipients to challenge with 10,000 larvae as measured by faecal egg counts. cells from a nonimmune donor did not have this effect. in a final experiment, washed cells from an immune triplet ...19846542246
some factors influencing the immunisation of sheep with irradiated haemonchus contortus larvae.over the last 6 years a number of experiments in which sheep were successfully immunised with 2 doses of 10 000 haemonchus contortus larvae, irradiated at 60 krad in a gamma-source, have been reported by the authors. in this paper, the failure of such a regimen of immunisation, using the same strain of larvae, is reported together with an investigation of the possible causes. technical errors were eliminated as a cause, on the grounds that the failure occurred in 2 separate laboratories using di ...19846542728
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