| [immunologic capacity of cancer patients and bcg-csw immunotherapy]. | | 1979 | 381535 |
| serial subculture of bcg on solid and liquid media. | to follow an earlier study of the effects on bcg of deep subculture in liquid media, transfers on the surface of löwenstein-jensen and sauton's media have been made. when a vaccine preparation that yields on culture 99+% of spreading-type colonies, with a small minority of non-spreading forms, is transferred on löwenstein-jensen medium, the minority population can be readily selected out. growth of bcg on this medium is not homogeneous, and the selection of either the minority or majority popula ... | 1979 | 382555 |
| isolation and identification of mycobacteria from cattle slaughtered in pakistan. | specimens of lung, liver and mesenteric lymph node from cows and buffaloes slaughtered in the lahore area were cultured to investigate the type of mycobacteria involved in bovine tuberculosis. employing the concentration method, 56 out of 530 cattle were found to be culture positive for acid-fast bacteria, 48 being mycobacterium bovis and eight atypical mycobacteria. no m tuberculosis or m avium was isolated. most of the isolated m bovis strains were found to be highly virulent for rabbits. | 1979 | 382608 |
| [role of bacteriological methods in the early detection of tuberculosis]. | | 1979 | 382634 |
| the tumoricidal properties of inflammatory tissue macrophages and multinucleate giant cells. | peritoneal exudate cells from c3h/hen mice infected with bacille calmette guérin (bcg) and subcutaneous inflammatory macrophages from uninfected mice exhibit spontaneous cytotoxicity for tumor cells in vitro, but their tumoricidal activity can be increased by incubation in vitro with lymphokines released by mitogen- or antigen-stimulated lymphocytes. inflammatory macrophages from these sites are only susceptible to activation in vitro by lymphokines for a short period (less than 4 days) followin ... | 1979 | 382866 |
| cell-mediated immune responses of neonatal calves and adult cattle following inoculation with ppd of mycobacterium bovis associated with a mycobacterial immunopotentiating glycolipid and oil droplets. | | 1979 | 382925 |
| potentiation of lymphocyte mitogenic responses to concanavalin a by antigen-activated peripheral blood monocytes. | purified protein derivative (ppd)-stimulated monocytes derived from mycobacterium bovis-sensitized cattle significantly potentiated lymphocyte mitogenic responses to concanavalin a (cona), as measured by incorporation of [3h] thymidine into cellular dna. monocytes were cultured for 24 hours in the presence of ppd, washed thoroughly, and mixed with purified lymphocytes; various doses of cona were added to these cultures, and the cultures were incubated for 4 days and assayed for dna synthesis. th ... | 1979 | 382926 |
| toxicity of intrapleural bacillus calmette-guérin treatment in animals. | the toxicity of intrapleural tice strain bacillus calmette-guérin (bcg) infection was tested in hamsters. doses above 10(6) colony-forming units caused significant systemic infection, which could be controlled with conventional antituberculosis therapy. living bcg in the pleural space did not prevent the healing of bronchial or vascular closures after pulmonary resection. prophylactic intrapleural bcg (10(6) colony-forming units) significantly reduced tumor growth in the lungs of mice following ... | 1979 | 383285 |
| [chronic hepatitis and immune stimulation]. | | 1979 | 383440 |
| [acute myeloic leukemia in adult age. significance and results of remission preserving therapy]. | | 1979 | 383441 |
| immunosuppressive activity of bcg: effects of adjuvant disease, lymphocyte subpopulations, and homing of thoracic duct cells in rats. | administration of bcg by various dosage schedules suppressed adjuvant disease in rats. bcg administration produced an initial increase, followed by a depression, of the phytohemagglutinin response of purified blood lymphocytes. an increase in absolute and relative numbers of bursa-equivalent (b)-cells followed bcg administration, concurrent with a decrease in the phytohemagglutinin responsiveness. with adjuvant alone, there was a diminution in phytohemagglutinin response and an increase in numbe ... | 1979 | 383618 |
| immunological behavior after mycobacterial infection in selected lines of mice with high or low antibody responses. | resistance and susceptibility to mycobacterial infection in the biozzi high and low lines of mice which were genetically selected for their responses to heterologous erythrocytes have been found to be related to the innate ability of nonimmune macrophages to kill or inhibit the growth of the organisms during the first two weeks after infection and to their ability to mount specific and nonspecific immune responses. high antibody-producer mice were more capable of expressing cell-mediated immune ... | 1979 | 383621 |
| in vitro induction of cytotoxic effector cells against human neoplasms. i. sensitization conditions and effect of cryopreservation on the induction and expression of cytotoxic responses to allogeneic leukemia cells. | peripheral blood lymphocytes (pbl) from normal human donors were sensitized in vitro against allogeneic human acute myelocytic leukemia (aml) cells by means of an unidirectional mixed lymphocyte-tumor cell culture (mltc) technique. the cytotoxic responsiveness of the sensitized lymphocytes, as determined in vitro by the 51cr-release assay, varied among individual lymphocyte donors and was greatly dependent on the sensitization culture conditions. induction of cytotoxic effector cells was augment ... | 1979 | 383844 |
| [the complement fixation test in leishmaniasis. comparison between an antigen extracted from leishmania cultures and one extracted from bcg]. | a comparison between a bcg antigen and various batches of an antigen extracted at different times from leishmania cultures in the fixation of complement reaction is reported. a better response was obtained with bcg (further confirmation on a larger series is being sought), whereas the leishmania antigens were difficult to prepare and their batch titres were not constant. | 1979 | 384298 |
| [comparative study of viable units of bcg vaccine]. | | 1977 | 384481 |
| [bovine tuberculosis in a cat (author's transl)]. | the clinical, radiographical and bacteriological findings in a siamese cat with bovine tuberculosis, are reported. in addition, the various forms of feline tuberculosis as well as the diagnostic procedures are reviewed. | 1979 | 384599 |
| scanning electron microscopy of epiplexus macrophages responding to challenge by bacillus calmette-guerin. | the present investigation examined the morphological characteristics of epiplexus macrophages following a single intracisternal injection of the antigen, bacillus calmette-guerin (bcg). three days following injection of bcg (0.5 - 4.0 x 10(8) viable microorganisms), mongrel dogs were perfused with buffered aldehydes. the choroid plexus of the lateral and third ventricles was removed and routinely prepared for scanning or transmission electron microscopy. choroid plexuses from normal animals (no ... | 1979 | 384740 |
| [effect of bcg endotoxin in hyperpigmentation with hypersideremia]. | | 1979 | 384872 |
| [dehydrogenases reducing nad+ in the presence of d (-) 3- phosphoglycerate in mycobacteria (bcg, h37ra, m. phlei)]. | referring to the elution volume on a sephadex g-150 column only one specific peak is obtained, the same for the bcg, h37ra and mycobacterium phlei strains grown on sauton synthetic medium. some properties of these partially purified dehydrogenases are studied (conservation and dialysis in media of different salt concentrations, equilibrium constant, km, heat stability). all enzyme preparations from tubercle bacilli (bcg, h37ra) are readily inactivated by heat and are very unstable in solutions o ... | 1979 | 385063 |
| the effects of histamine on leukocyte migration test in man. i. demonstration of a lif production inhibitor (lif-pi). | | 1979 | 385149 |
| c. parvum treatment of transplanted rat tumours of spontaneous origin. | c. parvum (wellcome cn6134) has been examined for suppression of a range of transplanted rat tumours of spontaneous origin. with five tumours (three mammary carcinomas and two fibrosarcomas) growth of comparatively high cell inocula (with respect to the minimum for growth in control rats) was suppressed by admixture with the vaccine. equivalent dry weights of glaxo, pasteur or connaught bcgs were relatively ineffective. intralesional injection of c. parvum into three three established tumours (t ... | 1979 | 385514 |
| macrophage stimulation by bacterial lipopolysaccharides. iii. selective unresponsiveness of c3h/hej macrophages to the lipid a differentiation signal. | peritoneal macrophages from the endotoxin-unresponsive c3h/hej substrain of mice were entirely refractory to activation in vitro by protein-free lps, a defect that was not overcome by co-culture of spleen cells from the responder c3h/st substrain with lps resistant c3h/hej macrophages. the defect in responsiveness appears confined to the lipid a activation signal since c3h/hej macrophages were fully activated after in vitro treatment by lipid a protein (lap)--lps complex, isolated lap, and bcg. ... | 1979 | 385780 |
| effect of thymosin treatment on antituberculous immunity in immunosuppressed mice. | | 1979 | 385871 |
| deer and health. | | 1979 | 386188 |
| direct effects of corynebacterium parvum and bcg on human monocyte-mediated tumour cell cytostasis in vitro. | four strains of corynebacterium parvum (cp) and bcg induced low levels of cytostatic ability to a human tumour cell line in human monocytes when added directly to conventional monocyte cultures. the cytostatic ability induced by mediators from autologous lymphocytes stimulated with the same agents was greater than that produced by direct addition to monocytes. bcg was more efficient in stimulating lymphocyte dna-synthesis and lymphokine release than any of the cp strains tested. in order to test ... | 1979 | 386712 |
| tumour-necrosis factor from the rabbit. iii. relationship to interferons. | | 1979 | 387059 |
| an epizootic of bovine tuberculosis in barbados, west indies. | a 57 cow dairy herd, believed to be in excellent condition and producing well, was found to contain 30 tuberculous cattle after cervical skin testing employing bovine ppd tuberculin with the single intradermal comparative test. testing was initiated after two cows from this herd were found at meat inspection to have tuberculosis. the reliability of bovine ppd tuberculin for testing as well as significant epidemiological, laboratory and meat inspection factors are presented. | 1979 | 387183 |
| cancer of the breast: morphological changes after peritumoral bcg as new parameters to choice of treatment and prognosis. | | 1979 | 387241 |
| immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed bcg cells and bcg cell walls. | heat-killed whole bcg cells (kc) and bcg cell walls (cw) were each tested in emulsified form for their potency to cause regression of a transplanted guinea pig hepatoma. on a weight basis, kc were at least as effective as cw in causing tumor regression and elimination of microscopic lymph node metastasis, and they, as well as purified protein derivative of mycobacteria, provoked delayed cutaneous hypersensitivity reactions in animals immunized with cw or with kc. on a weight basis, kc were as ac ... | 1979 | 387592 |
| inhibition by human serum of lymphocyte proliferation stimulated by purified protein derivative of tuberculin and bacillus calmette-guérin. | the addition of normal human serum to murine lymphocyte cultures consistently depressed mitogen-induced transformation, as measured by deoxyribonucleic acid synthesis. stimulation by the b-cell mitogens purified protein derivative-tuberculin, bacillus calmette-guérin, and lipopolysaccharide was consistently affected, but there was no inhibition of t-cells when human serum was added to concanavalin a-stimulated cultures. the inhibitory effects were not due to cytotoxic factors for b-lymphocytes o ... | 1979 | 387593 |
| regulation of mitogen- and antigen-stimulated lymphocyte blastogenesis by prostaglandins. | exogenously added prostaglandin e1 or e2 inhibited the blastogenic response of mycobacterium bovis-sensitized bovine peripheral blood lymphocytes stimulated with concanavalin a, phytohemagglutinin, or m. bovis purified protein derivative as measured by [3h]thymidine uptake. the kinetics of the response showed that prostaglandins must be added to lymphocyte cultures within hours after mitogen or antigen addition to achieve maximum suppression of [3h]thymidine uptake. addition of prostaglandins 24 ... | 1979 | 387607 |
| potency of 10 bcg vaccines as evaluated by their influence on the bacillemic phase of experimental airborne tuberculosis in guinea-pigs. | | 1979 | 387796 |
| increased mortality of cadmium-intoxicated mice infected with the bcg strain of mycobacterium bovis. | | 1979 | 387955 |
| [mycobacterial infections in nude mice (author's transl)]. | | 1979 | 388019 |
| interferon and cytotoxic factor (cytotoxin) released in the blood of mice infected with mycobacterium bovis bcg. ii. influence of time after bcg inoculation on production of interferon and cytotoxin by capsular polysaccharide of klebsiella pneumoniae or by bacterial lipopolysaccharide and on hyperreactivity to their lethal effects. | the time course of the occurrence of hyperreactivity in interferon and cytotoxin responses to the active substance (neutral fraction) of the capsular polysaccharide of klebsiella pneumoniae (neutral cps-k) and bacterial lipopolysaccharide (lps) and of the hyperreactivity to their lethal effects was followed after infection with bcg in sma and icr strains of mice. the duration of these hyperreactivities of bcg-infected mice depended on the inoculum doses of bcg. the time patterns of the hyperreac ... | 1979 | 388156 |
| [specific details in the defense of the respiratory apparatus against koch's bacillus]. | | 1979 | 388580 |
| scanning electron microscopy of the subarachnoid space in the dog: evidence for a non-hematogenous origin of subarachnoid macrophages. | injection of viable bcg into the subarachnoid space of immunized and non-immunized dogs produced a 10-fold increase in the populations of pial free cells. in immunized animals injected three days previously with bcg, stereoscopic sem revealed that many pial cells had rounded up and were protruding into the subarachnoid space. with continued rounding these cells took on amoeboid characteristics, with shapes that suggested a capacity for cell movement. internally, these pial cells possessed an inc ... | 1979 | 389020 |
| potentiation of the in vitro specific cytotoxic response to syngeneic lymphoma cells by ppd-stimulated tuberculin sensitive cells. | | 1979 | 389438 |
| mitogen stimulation of lymphocytes in cba mice exposed to lead and cadmium. | | 1979 | 389622 |
| the effect of bcg-vaccination on vaccinia virus infections in mice. | pretreatment with bcg yielded a high degree of protection against experimental vaccinia virus infections in mice. corynebacterium parvum and aristolochia acid were less protective; other immunostimulants were ineffective. | 1979 | 389657 |
| dietary immunostimulation: interaction with bcg and lps. | the action of bcg and lps mr595 used in conjunction with a formula-defined diet is dependent on the administration timing and resembles that of interacting adjuvants affecting different elements of the immune system. | 1979 | 389658 |
| suppression of phytohemagglutinin and lipopolysaccharide responses in mouse spleen cells by bacillus calmette-guerin. | | 1979 | 390143 |
| macrophage activation for tumor cytotoxicity: analysis of intermediary reactions. | | 1979 | 390144 |
| suppressed or enhanced antibody responses in vitro after bcg treatment of mice: importance of bcg viability. | mycobacterium bovis, bcg, is known to be capable of either enhancing or suppressing various immune responses. using a standard technique and number of organisms, some of the parameters predetermining whether enhancement or supression will occur have been investigated. dead bcg given intravenously into mice caused an enhancement of the antibody response in vitro to sheep erythrocytes. in contrast, the same number of viable organisms caused suppression if given intravenously but enhancement if giv ... | 1979 | 391696 |
| [pharmacodynamics of rifampicin--bacteriological and pharmacological action of rifampicin]. | | 1979 | 392153 |
| scanning electron microscopy of spinal nerve exits of normal and bcg-infected dogs. | | 1979 | 392706 |
| in vitro enhancement of natural cytotoxicity by tumour necrosis serum. | cells cytotoxic for syngeneic, allogeneic and xenogeneic cultured target cells are shown to be induced spontaneously in cultures of murine lymphoid cells. serum containing bacillus calmette-guérin and endotoxin-induced tumour necrosis factor accelerates the appearance of observed natural cytotoxic cells. | 1979 | 392738 |
| a biological study on hot-water extract from delipidated mycobacterium bovis strain bcg. | the biological activity of a hot-water extract from delipidated bcg, designated as hsa (hot-water soluble adjuvant), was investigated. the hsa did not induce hyperreactivity to bacterial endotoxin. the hot-water extract from which nucleic acids had been removed by streptomycin (sm-hsa) was found to enhance the delayed-type hypersensitivity as evidenced by the results of footpad reaction of mice. the hsa and sm-hsa could be injected to mice by an intraperitoneal route for 20 consecutive days with ... | 1979 | 392813 |
| in vivo and in vitro responses of cats sensitized with viable mycobacterium bovis (bcg). | cats were injected subcutaneously with viable mycobacterium bovis (bcg), and immune responses were evaluated at various times after injection. the bcg injection produced fever, leukocytosis, neutrophilia, and lymphadenopathy of regional lymph nodes. intradermal tuberculin injection produced responses consistent with delayed type hypersensitivity reaction in the treated cats at postinoculation day 21. skin responses to tuberculin were not significant at postinoculation day 49. the cellular infilt ... | 1979 | 393146 |
| susceptibility of rabbits to treponema pallidum after infection with mycobacterium bovis. | rabbits stimulated with mycobacterium bovis (strain bcg) one month before challenge with treponema pallidum (nichols) did not show any modification in their development of syphilitic lesions. a second infection with bcg given at the same time and at the same intradermal site as the t. pallidum challenge also failed to protect the rabbits against syphilis. thus the non-specific activation of cell-mediated immunity by bcg does not appear to protect rabbits against t. pallidum infection even when b ... | 1979 | 393361 |
| characterization of methanol extraction residue (mer) from bacillus calmette-guérin (bcg). | analysis of methanol extraction residue (mer) from bacillus calmette-guerin (bcg) was carried out to determine some specific chemical compositional characteristics. samples of mer were found to contain approximately 40% protein and/or peptide, 3% soluble lipids, 17% bound lipids, 8% elemental nitrogen, and less than 2% mycolic acids. amino acid analysis showed the presence of alanine, glycine and glutamic acid as the major amino acids. the data are reported in terms of the range found for each c ... | 1979 | 393679 |
| comparative immunogenicity of bcg substrains for mice. | immunogenicity of four substrains of bcg was studied in mice vaccinated by the intravenous route and evaluated through pulmonary density and through splenic, hepatic and pulmonary indexes (weight of the organ/weight of the animalx100). in addition, tuberculin sensitivity was determined by measuring the thickness of the inoculated leg. all four strains (bcg brazil, bcg prague, bcg russia and bcg glaxo) showed intermediary virulence (0.78 -- 0.85) between pathogenic mycobacteria, i.e., m. tubercul ... | 1979 | 394227 |
| cause of ill health and natural death in badgers in gloucestershire. | during the period 1973 to 1976 inclusive, 1206 badger carcases were examined for evidence of tuberculosis and other diseases. tuberculosis was the major cause of natural death, killing 39 per cent of the natural death cases, followed by bite wounding and starvation. road traffic accidents were the greatest single cause of death. | 1979 | 394469 |
| macrophage factors that enhance the antibody response. | the immunological mechanism of the primary in vitro antibody responses to sheep erythrocyte antigens involves soluble immunomodulatory factors. these studies have demonstrated that the stimulation of immunocytes with lipopolysaccharide (lps) induced the release of a helper factor which appeared to be a monokine. this helper factor was released by stimulated adherent splenocyte cultures but not by nonadherent cell populations. the p388d-transformed macrophage cell line also produced the factor in ... | 1979 | 394644 |
| viability counts on bcg vaccines for tumour immunotherapy: divergent effects on different growth media. | | 1979 | 394973 |
| antitumor activity of cell-wall skeleton of propionibacterium acnes c7 in mice and guinea pigs. | the antitumor activity of the cell-wall skeleton (cws) of propionibacterium acnes c7 was examined by using transplantable tumors in syngeneic mice and in guinea pigs, and autochthonous tumors in mice. p. acnes-cws was shown to suppress the growth of fibrosarcomas, el4 leukemia, and mh134 hepatoma in syngeneic mice, and to regress the established tumors of a fibrosarcoma (mc104) in c57bl/6j mice, and a hepatoma (line-10) in strain-2 guinea pigs. the oil-attached p. acnes-cws mixed with fructose m ... | 1979 | 395008 |
| human monocyte-mediated cytotoxicity to k-562 cells: activation by lymphokines. | human monocytes purified by adherence and prolonged in vitro monolayer culture were activated by supernatants of autologous lymphocytes stimulated with live bacillus calmette-guérin or killed corynebacterium parvum. activated monocytes expressed increased ability to lyse k-562 cells prelabelled with methyl-3h-thymidine in a 48 h assay. activation could be detected at a 1:64 dilution of lymphokine supernatants. target cell killing by activated monocytes was strongly influenced by the density of t ... | 1979 | 396667 |
| laboratory diagnosis of bovine tuberculosis. | lesions of suspected bovine tuberculosis were examined by culture, histopathology and auramine-o (ao) stained smears and the findings correlated with field aspects of the disease. of 642 lesions considered to be tuberculous, 62.0% yielded m. bovis and 4.5% other mycobacteria (om). m. bovis and om were recovered also from 0.6% and 3.6% respectively of 165 cattle which gave tuberculin reactions but had no visible lesions at slaughter. of 262 lesions in which a histopathological diagnosis other tha ... | 1979 | 396918 |
| ultrastructural changes in the alveolar epithelium in response to mycobacterial infection. | electron microscopic examination of the lung of mice infected with a virulent strain of m. bovis (ravenel) revealed marked alterations in the alveolar epithelial cells, particularly type 2 cells (granular pneumocytes), in addition to the development of interstitial and intra-alveolar granuloma. unlike the feature in uninfected mice, more than one type 2 epithelial cells were often found adjacent to one another within a single alveolus. some of these cells showed mitotic figures. their characteri ... | 1979 | 397360 |
| ultrastructural study of mycobacteria in experimentally produced lung lesions of mice. | mice were infected by iv injection with a virulent strain of mycobacterium bovis, ravenel strain, to prepare specimens for electron microscopical observation of their intracellular morphology. observation was made with ultra-thin sections of the granulomatous lungs at an advanced stage of infection. many apparently intact bacterial cells were found intracellulary, and the majority of them had lipoidal inclusions enclosed by a membranous structure. several layers of mycobacterial cell wall were d ... | 1979 | 397361 |
| ultrastructural studies on bronchial-associated lymphoid tissue (balt) and lymphoepithelium in pulmonary cell-mediated reactions in the rabbit. | | 1979 | 397746 |
| bcg-activated macrophages: comparison as effectors in direct tumor-cell cytotoxicity and antibody dependent cell-mediated cytotoxicity. | | 1979 | 397747 |
| macrophage activation for tumor cytotoxicity: mechanisms of macrophage activation by lymphokines. | | 1979 | 397754 |
| the treatment of established micrometastases with syngeneic macrophages. | we demonstrated that macrophages injected systemically can profoundly inhibit the incidence of experimentally induced metasis. in our system mice bearing established micro-metastases were treated with one, two, or three i.v. injections of activated macrophages. specificially activated (immune) macrophages were most efficient in reducing the number of metastases, but non-specifically activated macrophages were also effective in reducing the metastatic incidence. macrophage play a major role in ho ... | 1979 | 397756 |
| macrophages in immunity to syphilis: suppressive effect of concurrent infection with mycobacterium bovis bcg on the development of syphilitic lesions and growth of treponema pallidum in tuberculin-positive rabbits. | paired groups of male rabbits were challenged with treponema pallidum and mycobacterium bovis bcg. one group had been sensitized to bcg by inoculation 3 weeks before challenge. all animals were challenged intradermally at multiple sites with t. pallidum alone, bcg alone, and both organisms into the same sites. the resulting lesions were followed clinically and histologically. bcg lesions enlarged more rapidly in sensitized rabbits, but they were otherwise no different from those in the controls. ... | 1979 | 397934 |
| restoration of depressed antibody responses of leukemic splenocytes treated with lps-induced factors. | lipopolysaccharide and a nontoxic derivative, ps, from serratia marcescens were studied in terms of their effects on normal and friend leukemia virus depressed splenocytes. these materials caused a marked increase in the number of antibody producing cells by both groups of splenocytes. mdp, a synthetic analogue of myobacterial cell walls, produced a similar adjuvant response by normal and leukemic splenocytes. combinations of ps or lps and bcg or mdp resulted in synergistic immunostimulatory res ... | 1979 | 398146 |
| [vaccines against infectious rhinotracheitis of the cat adjuvant bcg aluminium hydroxide (preparation, control, immunity (author's transl)]. | | 1979 | 398244 |
| phagosome/lysosome fusion: a possible prerequisite for the enhancement of antibody responses in vitro by bcg, mycobacterium leprae and corynebacterium parvum. | primary in vitro antibody responses to srbc were suppressed in cultures prepared from the spleens of cba mice injected i.v. 20 days previously with 10(8) liver bcg. in contrast, cultures prepared from mice injected with dead bcg showed enhanced responses. in vitro spleen cell responses of the mice had returned to normal levels 4--6 weeks after their injection, but if dead bcg, m. leprae or c. parvum was added to the cultures, responses were enhanced. the enhancing effect of the added bacteria co ... | 1979 | 399339 |
| comparative results of freeze-drying and direct drying of bcg suspensions at different concentrations. | | 1979 | 400514 |
| [residual virulence of lyophilized commercial bcg-brazil vaccine, and of the one cultured in dubos media for mice]. | | 1979 | 400665 |
| [evolution and outcome of the tuberculous process produced by various mycobacterium tuberculosis in rabbits]. | | 1977 | 402002 |
| trypanosoma cruzi: infection of normal and activated mouse macrophages. | | 1977 | 403086 |
| [an immunological enhancement phenomenon in different experimental bacterial infections]. | to demonstrate that an enhancement phenomenon might be involved during the development of bacterial infections, one has to establish that specific humoral antibodies protect, in some way, microorganisms against the defence reations of the host. this report presents the evidence that specific antibodies could be evolved in assuming a certain survival of bacterial cells in host's tissue. (1) homologues antistaphylococcal sera passively potentiated the development of experimental staphylococcal syn ... | 1977 | 403848 |
| [antigens common to mycobacterium bovis (btszh) and several malignant and normal tissues of laboratory animals]. | agglutination, gel precipitation and immunoelectrophoresis tests demonstrated the presence of antigens common for the mycobacterium bovis (bcg) and some malignant and normal rat tissue cells. the method of absorption of immune sera in the agglutination test showed that this antigen was specific for the bcg microorganisms and cells of primary induced tumours of rat muscle tissue. this antigen had the electrophoretic mobility in the beta-globulin zone. | 1977 | 403974 |
| enhancement of carrier-mediated transport after immunologic activation of peritoneal macrophages. | immunologically activated peritoneal macrophages from inbred mice and hartley strain guinea pigs demonstrate a markedly greater than normal transport of 2-deoxy-d-glucose and l-leucine. the degree of nutrilite transport enhancement was greatest when animals were injected with the appropriate eliciting antigens before harvesting and also, if antigen was included in the tissue culture medium during the initial hours of in vitro culture. enhanced hexose and amino acid uptake could also be achieved ... | 1977 | 404359 |
| mitogenic activity of cell-wall components in mouse spleen cells. | | 1977 | 404503 |
| [preferential differentiation of hematopoietic stem cells transferred to mice previously infected by bcg]. | following injection of bone marrow cells in lethally irradiated mice, previously infected with bcg regenerating hemopoietic cell populations differentiate along the leucocyte pathway to the detriment of erythroid lineage. such a phenomenon persisting even if anemia of infected mice is increased by bleeding just before irradiation and reconstitution supports the hypothesis of preferential differentiation of stem cells. | 1977 | 406087 |
| stimulation of macrophages by cord factor and by heat-killed and living bcg. | trehalose-6,6'-dimycolate (cord factor; cf) injected into the peritoneal cavity of mice induced stimulation of the peritoneal macrophages, evidenced both by increased activity of the lysosomal enzyme, acid phosphatase, and by increased phagocytosis of listeria monocytogenes. the increase in enzyme activity and phagocytosis was similar to that induced by killed or living bcg. when administered intravenously, cf or bcg did not induce stimulation of peritoneal macrophages. cf when added to tissue c ... | 1977 | 406198 |
| mycobacteria isolated from exotic animals. | mycobacteria were isolated from 263 of 474 specimens submitted from captive exotic (nondomesticated) animals over a 5-year period. mycobacterium avium was isolated from 128 animals originating in 13 states and the district of columbia; serotype 1 accounted for 65 of the isolations. mycobacterium bovi was isolated from 74 animals in 7 zoos, 7 game parks, and 4 primate colonies in 1, states: mycobacterium tuberculosis was isolated from 29 animals originating 9 stats; and mycobacterium fortuitum, m ... | 1977 | 406254 |
| [types of mycobacteria and incidence of tuberculosis]. | | 1977 | 406615 |
| occult tuberculous infection in children. | three hundred and fifty new zealand children with occult tuberculous infection are reviewed. ninety four had received bcg vaccine previously. three hundred and forty were admitted to hospital and 3 gastric aspirations were obtained from each child and cultured for tubercle bacilli. mycobacterium tuberculosis was isolated from 1 or more aspirates in 29 (8.5%) of the children. excluding those who had received bcg the isolation rate was 10.9%. mycobacterium bovis was not cultured from any child. x- ... | 1977 | 406702 |
| suppression of cell-mediated immunity in experimental chagas' disease. | the effect of acute infection with the tulahuén strain of trypanosoma cruzi on the cellular immune response in swiss mice was studied. mice were immunized with either freund's complete adjuvant or oxazolone, a skin sensitizing agent, and subsequently skin-tested with either bcg protoplasm or oxazolone to detect delayed hypersensitivity. depression of the response to these antigens was observed in infected mice during the stage of marked parasitemia. mice which were responsive to oxazolone before ... | 1977 | 407736 |
| antibodies against bcg antigen 60 in mycobacterial infection. | a sensitive specific radioimmunoassay was developed to measure antibodies against bcg antigen 60, a prominent antigenic component of bcg bacilli which cross-reacts with similar components in many mycobacterial species including mycobacterium leprae and m tuberculosis. a lepromatous serum pool had anti-bcg-60 activity with a titre of 10(5) and the tuberculoid pool a titre of 10(4). testing of individual sera showed striking variations within groups of patients with lepromatous and tuberculoid lep ... | 1977 | 407965 |
| [enzymatic differences in mycobacteria. ribitol dehydrogenase]. | contrary to the tubercle bacilli (h37ra, bcg), mycobacterium phlei has a ribitol-nad dehydrogenase (that also oxidizes, although to a lesser extent, erythritol and glycerol). this difference is observed with the bacteria grown on sauton's medium, as well as after their adaptation to ribitol. the extracts of all these mycobacteria reduce, nadp in the presence of glycerol, ribitol or erythritol, though very slowly. | 1977 | 408036 |
| preservation of mycobacteria st -70 degrees c: persistence of key differential features. | the advantages of long-term preservation of suspensions of mycobacteria by storage at -70 degrees c established in earlier studies are reinforced by present evidence that freezer storage does not alter key taxonomic features used to identify mycobacteria. occasional discrepancies in biochemical test characteristics of mycobacteria that have been stored in the freezer and reconstituted at 37 degrees c reflect only sluggish metabolic activity, which is restored to normal on repeat testing. | 1977 | 408373 |
| in vitro immunisation against human tumour cells with bacterial extracts. | | 1977 | 408706 |
| [the use of purified lipopolysaccharides for serological diagnosis of tuberculosis]. | | 1977 | 408987 |
| in vitro studies on normal, stimulated and immunologically activated mouse macrophages. iii. intracellular multiplication of listeria monocytogenes. | the intracellular generation time of listeria monocytogenes is increased in monolayers of pe macrophages from mice immunized with bcg, listeria and t.a.b. vaccine as compared with monolayers of pe macrophages from normal mice stimulated intraperitoneally with proteosepeptone. thus non-specifically stimulated and immunologically activated macrophages, although sharing several other characteristics, differ in their capacity to control intracellular bacterial infection. | 1977 | 409099 |
| separation of the mixture of trehalose 6,6'-dimycolates comprising the mycobacterial glycolipid fraction, "p3". | | 1977 | 409398 |
| the relationship between the chemical structure of fatty acids and their mycobactericidal activity. | the bactericidal activity of long-chain fatty acids on mycobacteria was examined by exposing the organisms to these acids at 0.04 mm in 0.05 m acetate buffer (ph 5.6). the lethal effect of saturated fatty acids was related to the chain-length of hydrocarbon, c14:0 being the strongest in the activity and longer and shorter fatty acids being less active. unsaturation, isomerism and the presence of alpha-hydroxy group were found to be other factors governing the activity. the lethal effect was grea ... | 1977 | 409867 |
| effects of cortisone-treatment on experimental mouse infection with pathogenic and saprophytic mycobacteria. | | 1977 | 409870 |
| [simple propositions in the treatment of acute lymphoblastic leukaemia (author's transl)]. | acute lymphoblastic leukaemias which are, at the present time, curable are those which go 01.cfhçinto remission following treatment with the combination prednisone-vincristine, in which lymphoblastic meningitis does not occur after preventive treatment of the central nervous system and which show no recurrence during maintenance chemotherapy. in order that the largest possible number of these potentially curable patients may be transformed into truly cured cases, we propose here a simple outline ... | 1977 | 409993 |
| [isolation and identification of atypical mycobacteria (author's transl)]. | | 1977 | 410050 |
| [leukocyte migration inhibition with soluble and particulate antigens (author's transl]. | studies were carried out with the leukocyte migration inhibition tests using soluble and particulate antigens (ppd, somatic antigens of t. cruzi, m. bovis (bcg) and leukocytes from patients sensitized to ppd and patients with chronic chagas' disease. the results obtained showed that the stimulatory capacity of particulate antigens are greater than that of soluble antigens. | 1977 | 410077 |
| comparison of the mode of immunopotentiating action of bcg and wax d. i. effect on the immune response to srbc. | the immunopotentiating action of bcg and wax d was comparatively evaluated as the immune response to sheep red blood cells (srbc) in mice. the immunopotentiation of bcg varied with the interval between its priming and subsequent antigen injection. bcg increased delayed type hypersensitivity (dth) at early stage but enhanced antibody formation at later stage. dth reached its maximum about 5 weeks after bcg inoculation. in contrast, wax d increased antibody formation at early stage but increased d ... | 1977 | 410972 |
| [phagocytic activity of the leukocytes in patients with a newly established diagnosis of silicotuberculosis]. | | 1977 | 411124 |
| [isolation of mycobacterium tuberculosis cultures from soil]. | | 1977 | 411130 |
| [fluorescence microscopy in the diagnosis of tuberculosis]. | | 1977 | 412292 |
| lymphocyte transformation: an aid in the diagnosis of paratuberculosis. | | 1977 | 412443 |
| studies on corynebacterial precipitinogens common to mycobacteria, nocardiae and rhodochrous. | ten strains of corynebacterium were analyzed by means of the comparative immunodiffusion technique employing reference precipitation systems from strains of mycobacterium, nocardia and the rhodochrous taxon. the test strains had precipitinogens in common with the reference strains. two of the intergenerical cross-reacting precipitinogens revealed were labelled x and y. two other precipitinogens (alpha,beta), earlier found to be common for strains of mycobacteria, nocardiae, and rhodochrous, were ... | 1977 | 412795 |