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transfer of parental immunity to infectious laryngotracheitis in chicks.the transfer of parental immunity to infectious laryngotracheitis was appraised by measuring serum antibody levels in 150 chicks from the day of hatch up to five weeks. the breeder flock which had received primary vaccination at eight weeks and a booster at 20 weeks transferred high antibody levels which fell markedly within two weeks and remained constant thereafter. chicks whose parents were vaccinated at 20 weeks only, had low antibody levels throughout. these low levels, in either group of c ...1976187298
inhibition of herpesvirus saimiri replication by phosphonoacetic acid, benzo(a)pyrene, and methylcholanthrene.the present investigations were undertaken to determine the possible effects of two carcinogenic polycyclic aromatic hydrocarbons, benzo(a)pyrene and 3-methylcholanthrene on herpesvirus saimiri replication. the results from these experiments were compared with the effects of phosphonoacetic acid on the virus replication cycle. phosphonoacetic acid inhibited the synthesis of virus-induced intracellular late antigens, membrane antigens and infectious virus but not the synthesis of the early antige ...1977187336
cell surface markers on epithelial-burkitt hybrid cells superinfected with epstein-barr virus.attempts were made to superinfect two epithelial-burkitt hybrid cell lines, designated d98/hr-1 and d98/raji, with epstein-barr virus (ebv) and to investigate the expression of some cell surfacr markers including histocompatibility antigens, and the presence of b-cell markers, such as receptors for the third complement component and for monkey red blood cells. successful superinfection of d98/hr-1 cells with ebv was made evident by the expression of early antigen and, to a lesser extent, virus c ...1977193641
purification and subunit composition of guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung.the guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung was purified to apparent homogeneity by affinity chromography using 8-2-aminoethylthio-cgmp coupled to sepharose 4b. the kinase activity was purified approximately 6000-fold with an overall recovery of approximately 20%. the product isolated by affinity chromatography contained both cgmp-binding and cgmp-dependent histone kinase activity, indicating that the enzyme was not dissociated into regulatory and catalytic compon ...1977193862
alterations of acetylcholine enzymes in neuroblastoma cells persistently infected with lymphocytic choriomeningitis virus. 1977193868
[early stages of the infectious process]. 1977194438
human mutations affecting the low density lipoprotein pathway. 1977194472
[detection of cytomegalovirus in female genitals by means of a immunofluorescent method (author's transl)]. 1977196773
phosphatidate phosphohydrolase and the regulation of glycerolipid biosynthesis. 1977196962
amebiasis. an increasing problem among homosexuals in new york city.during a five-year period at the new york hospital, entamoeba histolytica was identified in the stools of 20 men who had not traveled outside the new york area. all of the patients were found subsequently to homosexual. during this same period amebiasis was diagnosed in 30 men who had traveled; only two were homosexual. of ten patients with e histolytica infection seen during the first year of this study, none were homosexual whereas eight of 11 patients in the fifth year were homosexual, sugges ...1977197276
substrate positions and induced-fit in crystalline adenylate kinase. 1977198550
an italian case of nasopharyngeal carcinoma correlated with epstein-barr virus specific antigens.an italian case of nasopharyngeal carcinoma was studied clinically; the immunologic study showed the correlation with the epstein-barr virus specific antigen.1977201063
effects of peptides of pituitary origin on the formation of c21 steroid by fetal calf adrenal cells in culture. 1977201254
studies on an energy structure-function relationship of dehydrogenases. i. calorimetric investigations on the interaction of coenzyme fragments with horse liver alcohol dehydrogenase. 1978204522
cyclic nucleotide phosphodiesterase. partial purification and characterization of a high affinity enzyme activity from human lung tissue.part of the soluble cyclic nucleotide phosphodiesterase activity of crude human lung tissue can be attributed to a thermosensitive (37 degrees) enzyme with a high apparent affinity for both adenosine 3':5'-monophosphate (cyclic amp) and guanosine 3':5'-monophosphate (cyclic gmp). the enzyme can be partially purified by deae-sephadex chromatography. in the presence of 0.1 mm edta or ethylene glycol bis(beta-aminoethyl ether)n,n'-tetraacetic acid (egta), it is eluted from the column immediately be ...1978204635
iron and copper metabolism in cancer, as exemplified by changes in ferritin and ceruloplasmin in rats with transplantable tumors. 1977205111
the renin-angiotensin system. 1978205167
solubilization and separation of delta5,3beta-hydroxysteroid dehydrogenase and 3-oxosteroid-delta4-delta5-isomerase from bovine adrenal cortex microsomes.a physical separation of delta5,3beta-hydroxysteroid dehydrogenase and 3-oxosteroid delta4-delta5-isomerase solubilized from bovine adrenocortical microsomes is described for the first time. the solubilization as well as the separation was carried out with a mixture of a detergent: a substituted betaine (empigen bb/p) and sodium cholate. this latter detergent protects isomerase from complete inactivation by empigen and is necessary for the recovery of a significant amount of soluble isomerase. s ...1978205261
the distribution of the inherited hl 1 and r 67 antigens on rabbit serum high density lipoprotein (hdl) particles.qualitative and quantitative analysis of the distribution of hl 1 antigen and r 67 antigen on high density lipoprotein (hdl) particles were conducted on six rabbit sera. the hl 1 antigen showed non-identity with a-i-containing hdl particles, and antiserum to hl 1 did not remove a-i-containing hdl particles. the r 67 antigen showed partial identity with a-i-containing hdl particles. antiserum to r 67 antigen removed 30--40% of a-i-containing hdl particles from the sera of animals which were heter ...1978205613
possible role of gamma-aminobutyric acid synthesis in the mechanism of dexamethasone feedback action.specific inhibition of glutamic acid decarboxylase (gad, ec 4.1.1.15; the main enzyme involved in the synthesis of gamma-aminobutyric acid) by mercaptopropionic acid interferes with the effect of dexamethasone on both the resting and stress-induced secretion of acth. it is postulated that dexamethasone may, at least in part, inhibit the secretion of acth via the induction of gad, thereby raising the level of gamma-aminobutyric acid in the central nervous system.1978205622
the movement of plutonium, americium, and curium through the food chain.the actinides, plutonium, americium and curium, are being produced in increasing quantites as the nuclear programme is expanded. as these alpha-particle-emitting elements are hazardous to man there is considerable concern about the movement of these elements through the environment; the uptake of these elements from soil into the plants is low, as is the gastrointestinal concentration factor. although there are complexing agents in the environment which have been shown to complex these elements ...1978205806
disseminated strongyloides stercoralis infection. association with ectopic acth syndrome and depressed cell-mediated immunity.a patient with disseminated strongyloides stercoralis was evaluated to elucidate host factors that may have led to the development of this infection. the patient was found to have oat cell carcinoma with hypercortisolism produced by tumor adrenocorticotropic hormone. his serum contained a potent inhibitor of lymphocyte blastogenesis. this patient's high level of endogenous cortisol may have impaired lymphocyte function and thereby facilitated infection with s stercoralis.1978206218
susceptibility of human skeletal muscle culture to influenza virus infection. part 2. ultrastructural cytopathology.cultured post-fused human skeletal muscle monolayers exposed to wsn influenza a virus were analyzed by scanning and transmission electron microscopy. at 12-14h post-inoculation (p.i.), affected mononuclear cells retracted from the cell surface, but remained anchored to the substrate by taut filar processes. retraction was accompanied by shortening of microvilli, appearance of hemispherical cytoplasmic protrusions and corrugation of the surface proper. these changes were more pronounced at 24 and ...1978206670
tumor antigen induction by the envelope-defective bryan strain of rous sarcoma viruses.chicken, quail, and turkey cells were infected and/or transformed by various avian leukosis or sarcoma oncovirus (alsv) strains as well as by the envelope-defective bryan high-titer strain of rous sarcoma virus [bh-rsv(-)]. all fibroblast-transforming avian sarcoma viruses (asv), including bh-rsv(-), were able to induce the expression of the previously described avian tumor-specific cell-surface antigen(s) (tssa). thus tssa was group-specific for all tested transforming asv. since bh-rsv(-) is a ...1978206708
in vitro inhibition of rat brain atpase pnppase, and atp-32pi exchange by chlorinated-diphenyl ethanes and cyclodiene insecticides. 1978207378
effects of substrates on tissue metabolic changes in the isolated rat heart during underperfusion and on release of lactate dehydrogenase and arrhythmias during reperfusion.in langendorff-perfused rat hearts, the perfusion pressure was reduced from 100 cm h2o to 20 cm h2o for 30 minutes to produce a model of global ischemia with a residual oxygen uptake. the release of lactate dehydrogenase (ldh) and the occurrence of ventricular arrhythmias during reperfusion were dependent on the substrate. glucose-perfused hearts had the highest rates of glycolytic atp production (2.5 mumol/g per min) during ischemia with normal contents of tissue cyclic adenosine 3',5'-monophos ...1978207459
neonatal haematological abnormalities associated with maternal disease. 1978207479
partial gonadotrophin-resistance in pseudohypoparathyroidism.a patient with classical albright's pseudohypoparathyroidism was investigated because of oligomenorrhoea. hypo-oestrogenism was associated with elevated basal gonadotrophin values [mean basal serum lh and fsh were 272 +/- 84 (sd) ng/ml and 593 +/- 83 ng/ml, resplectively (normal less than or equal to 220 and less than or equal to 400, respectively)]. the response to gonadotrophin releasing hormone (gn-rh) was exaggerated, with maximal lh and fsh increments of 1688 and 458 ng/ml, respectively. th ...1978208340
[hyperlipidemia in rats with chronic renal failure].the character of hyperlipidemia was studied in rats with chronic uremia induced by subtotal nephrectomy--5/6 of the renal tissue was removed. 13 to 30 weeks after this operation the blood serum cholesterol and phospholipid concentration almost doubled. hyperlipidemia was more pronounced in rats with high azotemia (blood urea nitrogen--bun). no elevation of serum tryglycerides occurred. total serum beta- and pre-beta-lipoproteins determined nephelometrically increased significantly only with the ...1978208685
the distribution of dietary plant sterols in serum lipoproteins and liver subcellular fractions of rats.rats were fed plant sterols containing campesterol and beta-sitosterol in the differerent proportions, and their distribution in serum lipoproteins and in liver subcellular fractions was determined. in serum lipoproteins, the percentage as well as the concentration of plant sterols increased with the increase in the density of lipoproteins. thus, high density lipoprotein (hdl) contained the highest and very low density lipoprotein (vldl), the lowest. also, there were distinct differences in the ...1978209282
unanticipated prevalence of symptoms among dairy farmers in michigan and wisconsin.adverse human health effects resulting from exposure to polychlorinated biphenyls (pbbs) were unknown until the accidental contamination of michigan dairy farm animal feed in 1973-1974. human exposure resulted from the consumption of contaminated meat, milk, dairy products, and eggs. in november 1976, the environmental sciences laboratory conducted comprehensive examinations of 933 farmers and residents in mighigan who were likely to have consumed farm products contaminated with pbb. a compariso ...1978209979
cytochrome oxidase activity of mitochondria in xenopus laevis previtellogenic oocytes. 1978211159
enhanced chemotactic and phagocytic activities of leukocytes in psoriasis vulgaris.leukocytes derived from the peripheral blood of psoriatic patients demonstrated an enhanced chemotactic response compared with leukocytes from healthy subjects. no significant difference was detected between the chemotactic response of leukocytes from patients with minimal or no skin involvement and those from patients with extensive lesions. psoriatic leukocytes also had a significantly higher capacity to engulf 125i labeled shigella flexneri than control leukocytes. it is postulated that a dec ...1978211169
evidence for the presence of serine-protease in the preparation of the very low density lipoproteins in human plasma. 1978212123
comparison of interferon action in interferon resistant and sensitive l1210 cells.translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ...1978212514
transfer of duck cell dna sequences to the nucleus of 3t3 cells by rous sarcoma virus.peking duck cell nuclear dna has no complementarity to rna of prague c rous sarcoma virus (rsv). upon infection of peking duck cells by prague c rsv, polynucleotide sequences complementary to peking duck cell nuclear dna can be detected in the high molecular weight rna from progeny peking duck cell passaged rsv (rsvpd) by rna.dna molecular hybridazation. when 3t3 cells are subsequently infected by rsvpd, polynucleotide sequences complementary to peking duck cell nuclear dna can be detected in th ...1978212741
age changes in collagen characteristics of bone and skin of a short-lived species of reptile.decalcified bone collagen of older male garden lizards, calotes versicolor, was less susceptible to digestion by collagenase from clostridium histolyticum than that from younger individuals. in aged skin the percentage solubility and the soluble/insoluble collagen ratio decreased, with a concomitant rise in insoluble and total collagen. collagen/unit area increased with advancing age in both dorsal and ventral skin. these results from a non-mammalian poikilothermic vertebrate provide additional ...1978212937
effect of interferon on murine leukemia virus infection. iii. effect of interferon on msv-induced transformation. 1978213891
increased spontaneous activity following substance p infusion into a10 dopaminergic area. 1978214711
evaluation of oxidative phosphorylation in hearts from euthyroid, hypothyroid, and hyperthyroid rats.the energy relationships between cytosolic and mitochondrial metabolism were studied in the hearts from euthyroid, hypothyroid, and hyperthyroid rats. isolated mitochondria showed high respiratory control ratios and impermeability to exogenous nadh. hypo- and hyperthyroidism, respectively, resulted in lower and higher contents of both cytochromes per mitochondrion and mitochondrial protein per gram of wet weight of heart without changes in the ratio of cytochrome c to cytochrome aa3. in isolated ...1978215035
opiate receptor agonists as modulators of gamma-aminobutyric acid turnover in the nucleus caudatus, globus pallidus and substantia nigra of the rat.the injection of various doses of morphine, subcutaneously, or of beta-endorphin, intraventricularly, changes the turnover rate of gamma-aminobutyric acid (trgaba) in the substantia nigra, globus pallidus and nucleus caudatus. the trgaba decreases in n. caudatus but increases in globus pallidus and substantia nigra. these changes are dose related and can be inhibited by naltrexone. the increased trgaba in globus pallidus elicited by these opioid receptor agonists may be associated with catalepsy ...1978215744
electrogenic events in the ubiquinone-cytochrome b/c2 oxidoreductase of rhodopseudomonas sphaeroides.the reductant of ferricytochrome c2 in rhodopseudomonas sphaeroides is a component, z, which has an equilibrium oxidation-reduction reaction involving two electrons and two protons with a midpoint potential of 155 mv at ph 7. under energy coupled conditions, the reduction of ferricytochrome c2 by zh2 is obligatorily coupled to an apparently electrogenic reaction which is monitored by a red shift of the endogeneous carotenoids. both ferricytochrome c2 reduction and the associated carotenoid bands ...1979216398
mitochondrial reduced nicotinamide-adenine dinucleotide dehydrogenase is transmembranous [proceedings]. 1978217785
[blood transfusion and viral diseases. recent acquisitions concerning viral hepatitis viruses, cytomegaloviruses and epstein-barr virus].in recent years, an increasingly clear picture has been formed of the virus-induced syndromes that may follow a blood transfusion or the use of blood derivatives. up to about 10 years ago, post-infusion infection was predominantly due to serum hepatitis. blumberg's discovery of hbsag (formerly known as australia antigen) has made it possible to check and prevent viral hepatitis, type b, and to recognise such distinct forms as the mononucleosis-like syndrome caused by cytomegalic virus, infectiou ...1979219399
agents affecting health of mother and child in a rural area of kenya. xi. antibodies against rotavirus in sera from children living in the machakos district of kenya.207 sera from children under 5 years of age and living in the machakos district in kenya were tested in the complement fixation test for antibodies against rotavirus. two different antigens were used. the superiority of 'o' antigen over nebraska calf diarrhoea virus antigen was confirmed. after a fall to 29 percent in the 6-8 months age group, the percentage of children with antibodies quickly rises with age to 80 percent at the age of 24 months and to practically 100 percent at the age of 30 mo ...1978219569
transcription of the marek's disease virus genome in a nonproductive chicken lymphoblastoid cell line. 1979219594
shigella infection of henle intestinal epithelial cells: role of the host cell.the process of henle 407 embryonic intestinal epithelial cell infection by shigella flexneri 2a m42-43 was studied in an in vitro model system. the role of the henle cell was assessed. it was established that entry of s. flexneri into cells was suppressed by reagents which inhibit uptake of particles by phagocytic cells. the compounds tested included cytochalasin b, dibutyryl-cyclic adenosine monophosphate, choleragen (vibrio cholera enterotoxin), iodoacetate, and dinitrophenol. cytochalasin b i ...1979223988
ornithine decarboxylase activity, cell proliferation, and tumor promotion in mouse epidermis in vivo.the effect of different phorbol esters and of mechanical treatment on the activity of ornithine decarboxylase in mouse epidermis in vivo was investigated. the strong promoter 12-o-tetradecanoylphorbol-13-acetate as well as the weak promoters phorbol dibenzoate and the 12-o-tetradecanoylphorbol-13-acetate analog 12-o-tetradeca-2-cis, 4-trans-6,8-tetraenoylphorobol-13-acetate strongly increased the activity of the enzyme and the intraepidermal level of putrescine, with a maximum at 5 hr after appl ...1979225017
isolation of foot-and-mouth disease virus messenger rna from membrane-bound polyribosomes and characterization of its 5' and 3' termini. 1979228483
[effect of furazolidone on the cyclic nucleotide level in the blood plasma in acute dysentery]. 1979229573
adenosine and deoxyadenosine kinase from rat liver. 1979232628
isolation of the lymphocytosis promoting factor-haemagglutinin of bordetella pertussis by affinity chromatography.the lymphocytosis promoting factor-haemagglutinin of bordetella pertussis was isolated from solutions obtained after cell disintegration by a novel affinity chromatographic method using an adsorbent composed of human haptoglobin covalently attached to a sepharose 4b matrix. the haemagglutinin was bound to the adsorbent at ph 6.5 and eluted by a stepwise change to a ph 10 buffer. a 300--600-fold purification of the haemagglutinin was achieved by this one-step process. the chemical and biological ...1979232665
natural antibodies in healthy adults.the serum of 100 adults living in budapest was examined for isohaemagglutinin titre with haemaglutination, for staphylococcal-antitoxin titre with haemolysis inhibition and for bacterial antibody titre against 17 different groups of bacteria with passive haemagglutination. antibody levels in males, except for certain bacterial antibodies, were somewhat lower than in females. the antibody titres, especially in men, decreased gradually from 20 to 50 years of age and were usually lower in rh negati ...1975235827
standardisation of the nitroblue-tetrazolium test.optimal conditions for the nbt-reduction test have been sought. increasing heparin concentrations up to 100 units per ml and a delay in performance of the test, especially when blood specimens are kept at room temperature, resulted in higher values for the nbt index, which then sometimes exceeded the upper limit of normal in healthy people and in uninfected patients. the effect of ph, composition of the buffer, and dye concentration was also investigated. phosphate-buffered saline ph 7-2 contain ...1975238038
inhibition of pathogenic enteric bacteria by hyperbaric oxygen: enhanced antibacterial activity in the absence of carbon dioxide.the antibacterial effects of 24-h exposures to high-pressure oxygen in relation to environmental co(2) were studied at 3 atm absolute (ata) and at 1 ata. eight gram-negative, aerobic and facultatively aerobic, pathogenic enteric bacteria (salmonella typhosa, salmonella paratyphi, salmonella schottmuelleri, shigella dysenteriae, shigella flexneri, proteus vulgaris, pseudomonas aeruginosa, and escherichia coli) were exposed as shallow-broth cultures and agar surface cultures. although broths suppl ...1975238466
[development of new types of chemical vaccine for prevention of intestinal infections and problems of their qualitative evaluation. iii. comparative study of immunologic characteristics of experimental antigenic preparations].as a result of comparative study of the immunological properties and antigenic activity of thyphoid, paratyphoid a and b and sonne and flexner dysentery antigenic preparations obtained by various methods there was revealed a decreased toxicity of the experimental preparations of the tashkent and leningrad institute of vaccines and sera (in comparison with the tryptic antigens) and a considerable advantages of the experimental thyphoid and paratyphoid antigenic preparations by their capacity to i ...1975239506
vomiting and shock in advanced pregnancy (a case report). 1979257956
regional anesthesia in cattle. 1979260529
changes in rat lung produced by olivine dust inhalation. 1979262291
dextro-phenylalanine as inhibitor of the noradrenaline release from the isolated rat hypothalamus.in slices of isolated rat hypothalamus, the dextrophenylalanine (d-phe) 3x10(-3)m produced an inhibition of a 47% in the fractional release of 3h-na to the preparations of holtzman rats, and of 39% to the wistar rats, when the concentration of d-phe (in this last) was of 1x10(-2)m, pointing that the effectiveness of the d-phe is variable with the employed rat root. the mentioned effect is calcium dependent, for it was antagonized when the ca++ was incremented in the medium of 1,68mm (normal) to ...1979262354
biologic properties of lyophilized live typhoid vaccine strains. 1979262514
[evolution of the repartition of enteropathogenic enterobacteria serotypes isolated in algeria from 1974 to 1977].the authors survey the enteropathogenic enterobacteria studied from 1974 to 1977 and draw the following conclusions : s. typhi is still the predominant serotype. among salmonella, other than s. typhi and s. paratyphi, s. wien remains the most frequently reported serotype while progressively decreasing from 1974 to 1976 and is supplanted by s. infantis in 1977. among the 847 strains of shigella examined, a high frequency of shigella flexneri is noted with shigella sonnei following by a wide margi ...1978262974
brain growth-promoting activity in human serum: relationship to growth hormone and somatomedin.brain growth-promoting activity and somatomedin activity were assessed in serum collected from patients with pituitary disorders of gh secretion. brain growth-promoting activity correlated with somatomedin activity in serum, and both rose in response to gh administration.1978263343
[use of antibiotics and side effects of an anti-inflammatory agent, ibuprofen, in the aged]. 1977266551
increase of proliferative activity of leukaemic blast cells from human peripheral blood in liquid culture.the proliferative behaviour of leukaemic cells from the peripheral blood of 12 patients suffering from acute leukaemia was investigated in short term liquid culture. in 3 cases of aml an increase of the blast cell number was observed exceeding the initial value whereas in 9 other cases the cell number decreased more or less rapidly. in 9 of these patients the proliferation kinetics of the cultured leukaemic blast cells were studied with 3h-thymidine labelling. in all these cases the labelling in ...1977267311
the role of the mandible in mouse palatal development revisited.growth changes associated with formation of the secondary palate were studied in h-velaz mouse embryos by morphometric measurement of medial sagittal sections of the heads between days 13 and 15 of embryonic development. horizontalization of the palatine processes depends primarily on the length of the mandible and is effected by a shift of palatine process material into the supralingual space. the administration of 7.5 mg cortisone acetate im to the female on day 12, of 0.5 mg 6-aminonicotinami ...1977267520
characterization of glycogen in selected tissues of turkey poults with spontaneous round heart disease and furazolidone-induced cardiomyopathy.furazolidone (fz) at 700 ppm was added to feed mixtures fed turkey poults 2--5 weeks after hatching to induce acute experimental cardiomyopathy. poults in the control pen received the same ration but without fz. from ekg data obtained at weekly intervals, poults were selected for sacrifice at 5 and 10 weeks of age. poults were sacrificed by cervical dislocation and appropriate samples of tissue from the left ventricle, liver, pectoralis and tibialis cranialis muscles were removed for glycogen as ...1978277049
internal structure of the nucleosome: dna folding in the conserved 140-base-pair core particle. 1978277366
structure-function relationships in lipotropins. 1977279263
survival of haemophilus equigenitalis in different antibiotic-containing semen extenders.the ability of haemophilus equigenitalis, the causal agent of contagious equine metritis 1977, to survive in various antibiotic-containing semen extenders was studied at different environmental temperatures. gentamicin sulphate was found to be markedly superior to ampicillin or a combination of sodium benzyl penicillin and polymyxin b sulphate, semen treated with the former antibiotic was either sterile at cultural examination or else yielded appreciably fewer colonies of h. equigenitalis than t ...1979289812
significance of lipid peroxidation in the genesis of chronic vasospasm following rupture of an intracranial aneurysm. 1979290253
the afferent fibres of the sympathetic nervous system. 1979290263
the proportional volume of mucous acinar cells in normal human submandibular salivary glands. 1979294238
glc determination of indoprofen in plasma.implementation of human bioavailability studies with the analgesic indoprofen required a rapid, sensitive, and convenient assay in blood plasma. a procedure based on ether extraction of acidified plasma, derivatization with diazomethane, and glc analysis using a 3% ov-1 column was sufficiently sensitive for measurement of plasma indoprofen concentrations in the 0.4-16 mug/ml range. an average recovery of 99.0 +/- 7.6% (sd) was achieved when the pentanoic acid homolog was employed as an internal ...1977299889
familial trisomy 20p five cases and two carriers in three generations a review.a clinically normal mother of three retarded children has been determined by g-banding to have a balanced translocation 46,xx,t(13;20) (q34;p11.2). the children each have an unbalanced form of the translocation with partial trisomy for 20p. extensive gene marker studies have been unable to affix any specific gene locus onto the short arm of chromosome 20. the balanced translocation was inherited from the maternal grandfather. two phenotypically abnormal deceased members of the family are believe ...1977302689
urogastrone levels in the urine of normal adult humans.urogastrone is a potent inhibitor of gastric acid secretion isolated from human urine and it is structurally related to and shares the properties of a potent mitogen-mouse epidermal growth factor. the amounts of urogastrone in 24 h normal human urine samples were measured using a specific and sensitive radioimmunoassay. values varied from 120--1360 ng/kg/24 h but a significant difference (2p less than 0.005) was observed between urine samples from men (602 +/- 41 se, n = 39) and women (782 +/- 4 ...1977303242
spontaneous cytotoxicity of human peripheral blood mononuclear cells toward red blood cell targets. ii. time-dependent loss of suppressor cell activity.in a previous paper we demonstrated that human peripheral blood mononuclear cells become strikingly cytotoxic toward a wide variety of red blood cell targets after 7 days of in vitro culture. the cell responsible for cytotoxicity does not rosette with srbc and demonstrates both surface adherence and phagocytic properties. in this paper we wish to show that development of spontaneous cytotoxicity is due to a time-dependent loss of suppressor cell function. fresh autologous lymphocytes, when added ...1977303249
kinetics of antibody response in unprimed recipients after transfer of immune lymphocytes.spleen cells from mice immunized with srbc were transferred, at various times after immunization, to non-irradiated and lethally irradiated syngeneic recipients. the pfc kinetics and anti-srbc antibody titres were followed in various groups of mice. similar results were obtained both in non-irradiated and lethally irradiated recipients, showing that after the transfer: a) pfc proliferation was blocked, b) pfc blocking was unrelated to their maturation stage, c) resting pfc were still able to syn ...1978308888
the cerebellar arteries in the cat and areas supplied by them. 1978308899
[vaccination of ducklings against pasteurellosis and viral hepatitis]. 1979313121
acute epiglottitis: 26 years' experience at the montreal children's hospital.two hundred and four cases of acute epiglottitis treated at the montreal children's hospital between 1951 and 1978 are reviewed. the comparison of tracheostomy vs. nasotracheal intubation is discussed. nasotracheal intubation has been found to be the treatment of choice as long as the necessary services are available in the hospital.1979313456
[arterio-veinous malformations located within the occipito-cerebello-mesencephalic dihedral (author's transl)].about 4 cases of arterio-veinous malformations located within the occipito-cerebello-mesencephalic dihedral (which is this region of the brain including the cistern of galen and the surrounding formations : the quadrigeminal bodies forwards, the splenium of the corpus callosum upwards, the upper face of the cerebellum and the pedonculus cerebellaris superior below) the authors related their own experience. these 4 cases are detailed from a clinical point of view. them, a synthetic study is under ...1978313528
formation of a stable complex between human proelastase 2 and human alpha 1-protease inhibitor. 1979313930
[traveler's diarrhea]. 1977319371
reiter's syndrome following shigella flexneri 2a: a sequel to traveler's diarrhea. report of a case with hepatitis.shigella flexneri 2a was isolated from a patient with reiter's syndrome (rs) following a family outbreak of traveler's diarrhea. among 3 members at risk, only the patient was positive for hla-b27. data from 3 similar families support the hypothesis that susceptibility to rs is genetically transmitted. it is urged that every effort be made to culture and subtype shigella and other enteric pathogens in rs following diarrhea. concurrently, the patient had hepatitis, interpreted as a parallel enteri ...1977319805
[formation of the dysentery epidemic process in three small towns].data are presented concerning the epidemiological analysis of sonnei dysentery outbreaks in three towns connected by common nutrition and water supply. the epidemic processes in these populated localites were strongly interrelated. possibilities of the effect of the water factor on the extent of sonnei dysentery incidence were studied as well. the results of studies led to the conclusion on the presence of numerous action forms of the water factor which should be taken into consideration in carr ...1977320797
[test of the safety, reactogeneity and immunogeneity of live flexner 2a and sonne dysentery vaccine from spontaneous mutants, prepared in dragee form, in a controlled experiment on adults].controlled experiment was conducted on 428 adult persons. a study was made of the reaktogenic properties and the immunological activity of live enteral dysentery vaccine flexner 2a and sonne from the spontaneous mutants developed at the n.f. gamaleya institute of epidemiology and microbiology. the vaccine is prepared in the form of sugar-coated pills covered with an acid-fast substance protecting from the gastric juice action. a single administration of the vaccine in a dose of up to 4 pills (6 ...1977320801
volume and shape of normal human spermatozoa.an improved apparatus for measuring the electrical size of particles, developed in this laboratory and based on the principle of the coulter counter, is used to size human spermatozoa. the typical size distribution is unimodel, with a skew to the right. the actual quantity determined by the measuring system is electrical size (i.e., shape factor x volume); in order to extract the volume, it is necessary to obtain an independence measure of particle shape. this is done by estimating the relative ...1977321264
conservation of transfer ribonucleic acid and 5s ribonucleic acid cistrons in enterobacteriaceae.the genes for tranfer ribonucleic acid (tdna) and 5s ribonucleic acid (5sdna) were isolated from the total deoxyribonucleic acid (dna) of escherichia coli. the relatedness of tdna and 5s from e. coli and other species of enterobacteriaceae was determined by reassociation of the isolated genes labeled with 32po4 to unlabeled, unfractionated dna. double-stranded dna was separated from unreacted dna by hydroxyapatite chromatography. thermal elution profiles were done to determine the amount of unpa ...1977321428
a simple one-step hemolytic assay for c2 with c2-deficient human serum.a simple one-step procedure has been developed for the molecular titration of c2 by utilizing the ability of the test material to restore the hemolytic activity of human serum selectively deficient in c2 (c2d serum). in this assay, equal volumes of ea (10(8) cells/ml), c2d serum (1/20), and a suitable dilution of a source of c2 were incubated at 37 degrees c for 60 min and the fraction of cells lysed was used to calculate the effective molecules of c2/ml test material. the assay can be used to t ...1977321681
protection by hypoxia and the effect of low oxygen tensions on radiosensitivity. 1977323029
biological properties of shigella flexneri 2a toxin and its serological relationship to shigella dysenteriae 1 toxin.a toxin extracted from heat-inactivated, alkaline-treated shigella flexneri 2a showed biological properties similar to those of shigella dysenteria 1 toxin. the s, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for hela cells. a serological relationship between s. flexneri 2a and s. dysenteriae 1 toxin was shown with cross neutralization tests.1977323142
the pathogenesis of shigella diarrhea. vi. toxin and antitoxin in shigella flexneri and shigella sonnei infections in humans.two strains of shigella flexneri and one of shigella sonnei were studied for toxin production in vitro. all of the three strains produced a cell-free cytotoxin that showed marked similarity to that produced by shigella dysenteriae 1. each toxin eluted in two distinct peaks on chromatography with sephadex g-150, was destroyed by heating at 90 c for 30 min, and was neutralized by s. dysenteriae 1 antitoxin. patients with infections due to s. flexneri and s. sonnei developed antibody that neutraliz ...1977323376
clinical and laboratory assessment of the pathogenicity of serotyped enteropathogenic escherichia coli.only one of 167 separate isolates of enteropathogenic escherichia coli (eec) was shown to produce enterotoxin, and none of the 167 isolates were invasive. clinical features of 123 hospitalized children with eec were compared with those of 917 infants with nonbacterial gastroenteritis and 145 infants infected with shigella. the average duration of diarrhea (five or more stools per day) in hospitalized children with eec, nonbacterial gastroenteritis, shigella flexneri, and shigella sonnei was 4.6, ...1977323379
phagocytosis stimulation by an extracellular product of virulent shigella flexneri 2a. 1977323646
trimethoprim-sulfamethoxazole compared to ampicillin in the treatment of shigellosis.twenty hospitalized children between 1 and 11 years of age were enrolled in a comparative randomized evaluation of trimethoprim-sulfamethoxazole (tm-sm) and ampicillin for the treatment of shigellosis. each drug was provided for five days. the group treated with ampicillin had significantly more stools per day (mean 21.25) compared to the tm-sm group (8.64). treatment with tm-sm appeared to be associated with a more rapid reversion of stool cultures to normal, but these differences compared to a ...1977323811
[functioning of the kspa-gene in f'-merodiploids of flexner shigellae]. 1977324195
[diagnosis and treatment of acute dysentery]. 1977325896
[our experiences with water-induced epidemics of bacillary dysentery]. 1977325899
postdysenteric reiter's syndrome. 1977325904
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