| recruitment of lymphocytes to human liver allografts during rejection. | | 1990 | 2219381 |
| cerebrospinal fluid changes after 48 hours of effective therapy for hemophilus influenzae type b meningitis. | interval cerebrospinal fluid (csf) analysis is often performed to assess efficacy of treatment for bacterial meningitis. the authors reviewed 101 cases of pediatric bacterial meningitis resulting from hemophilus influenzae type b in which analysis of csf occurred on admission and between 48 and 72 hours after initiation of parenteral antibiotic therapy; of these, only one patient had a positive repeat csf culture. of the 100 cases with sterile csf on repeat culture, there was no instance of recr ... | 1990 | 2220669 |
| problems with current recommendations for susceptibility testing of haemophilus influenzae. | we compared results of mic and disk susceptibility tests on haemophilus test medium (htm) and those on comparative media. ampicillin mics were determined with seven ampicillin-resistant, non-beta-lactamase-producing (amprnblp) isolates by using htm and supplemented brain heart infusion (sbhi) agar. ampicillin and amoxicillin-clavulanate disk tests with 16 amprnblp strains, 18 ampicillin-susceptible (amps) isolates, and 17 ampicillin-resistant, beta-lactamase-producing (amprblp) strains were perf ... | 1990 | 2221855 |
| buccal cellulitis. | buccal cellulitis (bc) is an innocuous appearing infection of the cheek that is found in children and has a high incidence of concomitant bacteremia. typically, the child is younger than 12 months and has a 2 to 8 hour prodrome of coryza and fever before developing the cellulitis on the cheek. a purplish hue on the cellulitic region is highly suggestive of hemophilus influenzae bacteremia. the differential diagnosis is reviewed. a complete blood count, blood culture, and cellulitis aspirate cult ... | 1990 | 2222602 |
| characterization of the cdna coding for mouse prothrombin and localization of the gene on mouse chromosome 2. | a series of overlapping cdnas coding for mouse prothrombin (coagulation factor ii) have been isolated and the composite dna sequence has been determined. the complete prothrombin cdna is 1,987 bp in length [excluding the poly(a) tail] and codes for 18 bp of 5' untranslated sequence, an open reading frame coding for 618 amino acids, a stop codon, and a 3' untranslated region of 112 bp followed by a poly(a) tail. the translated amino acid sequence predicts a molecular weight of 66,087, which inclu ... | 1990 | 2222810 |
| interleukin-4 regulates mrna accumulation of macrophage-colony stimulating factor by fibroblasts: synergism with interleukin-1 beta. | we demonstrate that macrophage-colony stimulating factor (m-csf) is expressed in human fibroblasts at the mrna and protein level. following activation with both interleukin (il)-1 beta and il-4, fibroblasts synthesized m-csf transcripts detectable by northern blot analysis with peak expression occurring at 8 h and 12 h, respectively. exposure of fibroblasts to both cytokines resulted in m-csf protein release at 60 h of c. 500 u/ml (for il-1 beta) and 1000 u/ml (for il-4), relative to a control p ... | 1990 | 2223651 |
| interleukin-4 regulates mrna accumulation of macrophage-colony stimulating factor by fibroblasts: synergism with interleukin-1 beta. | we demonstrate that macrophage-colony stimulating factor (m-csf) is expressed in human fibroblasts at the mrna and protein level. following activation with both interleukin (il)-1 beta and il-4, fibroblasts synthesized m-csf transcripts detectable by northern blot analysis with peak expression occurring at 8 h and 12 h, respectively. exposure of fibroblasts to both cytokines resulted in m-csf protein release at 60 h of c. 500 u/ml (for il-1 beta) and 1000 u/ml (for il-4), relative to a control p ... | 1990 | 2223651 |
| effects of maternal undernutrition and exercise on glucose kinetics in fetal sheep. | fetal glucose kinetics were measured using a combination of isotope-dilution and fick-principle methodology in single-pregnant ewes which were either well-fed throughout, or fed at 0.3-0.4 predicted energy requirement for 7-21 d during late pregnancy. all ewes were studied while standing at rest and then while walking on a treadmill at 0.7 m/s on a 10 degree slope for 60 min. underfed ewes suffered major decreases in fetal total disposal rate, fetal-placental transfer and umbilical net uptake of ... | 1990 | 2223747 |
| effects of maternal undernutrition and exercise on glucose kinetics in fetal sheep. | fetal glucose kinetics were measured using a combination of isotope-dilution and fick-principle methodology in single-pregnant ewes which were either well-fed throughout, or fed at 0.3-0.4 predicted energy requirement for 7-21 d during late pregnancy. all ewes were studied while standing at rest and then while walking on a treadmill at 0.7 m/s on a 10 degree slope for 60 min. underfed ewes suffered major decreases in fetal total disposal rate, fetal-placental transfer and umbilical net uptake of ... | 1990 | 2223747 |
| structure and function of hemoglobin variants at an internal hydrophobic site: consequences of mutations at the beta 27 (b9) position. | we have studied the structure-function relationships in newly discovered hemoglobin (hb) mutants with substitutions occurring at the tight and highly hydrophobic cluster between the b and g helices in the beta chains, namely, hb knossos or beta a27s and hb grange-blanche or beta a27v. the beta a27s mutant has a 50% decrease in oxygen affinity relative to native human hb a, while the beta a27v mutant has an increased oxygen affinity. we have also engineered the artificial beta a27t mutation throu ... | 1990 | 2223757 |
| structure and function of hemoglobin variants at an internal hydrophobic site: consequences of mutations at the beta 27 (b9) position. | we have studied the structure-function relationships in newly discovered hemoglobin (hb) mutants with substitutions occurring at the tight and highly hydrophobic cluster between the b and g helices in the beta chains, namely, hb knossos or beta a27s and hb grange-blanche or beta a27v. the beta a27s mutant has a 50% decrease in oxygen affinity relative to native human hb a, while the beta a27v mutant has an increased oxygen affinity. we have also engineered the artificial beta a27t mutation throu ... | 1990 | 2223757 |
| the yeast 5s rrna binding ribosomal protein yl3 is phosphorylated in vivo. | the 5s rrna-ribosomal protein yl3 ribonucleoprotein particle was isolated from yeast cells labeled with [32p]orthophosphate. the protein moiety was purified and found to be radioactive. labeled phosphoserine was detected after partial hydrolysis of the protein. up to two phosphate residues are sterified per mole of yl3 ribosomal protein. | 1990 | 2223876 |
| the yeast 5s rrna binding ribosomal protein yl3 is phosphorylated in vivo. | the 5s rrna-ribosomal protein yl3 ribonucleoprotein particle was isolated from yeast cells labeled with [32p]orthophosphate. the protein moiety was purified and found to be radioactive. labeled phosphoserine was detected after partial hydrolysis of the protein. up to two phosphate residues are sterified per mole of yl3 ribosomal protein. | 1990 | 2223876 |
| [the evaluation of the age-related characteristics of the structural status of the plasma membrane lipid phase in rat fatty tissue by using the method of inductive-resonance energy transfer]. | using the method of inductance-resonance energy transfer from tryptophanyl residues to fluorescent pyrene probe the structural state of plasmatic membranes from adipose tissue of different age rats has been studied. the structural heterogeneity of membrane lipid phase has been revealed. the differences in physical properties of annular and bilayer lipids don't depend on age. during aging the membrane lipid viscosity including lipids of near protein area decreases, the conformation of membrane pr ... | 1990 | 2223908 |
| [the evaluation of the age-related characteristics of the structural status of the plasma membrane lipid phase in rat fatty tissue by using the method of inductive-resonance energy transfer]. | using the method of inductance-resonance energy transfer from tryptophanyl residues to fluorescent pyrene probe the structural state of plasmatic membranes from adipose tissue of different age rats has been studied. the structural heterogeneity of membrane lipid phase has been revealed. the differences in physical properties of annular and bilayer lipids don't depend on age. during aging the membrane lipid viscosity including lipids of near protein area decreases, the conformation of membrane pr ... | 1990 | 2223908 |
| implantation and in vivo antagonistic effects of antibiotic-susceptible escherichia coli strains administered to premature newborns. | two antibiotic-susceptible and non-pathogenic escherichia coli strains were administered to hospitalized premature infants in order to protect them from intestinal colonization by hospital-acquired antibiotic-resistant enteric organisms (eos). three groups of 16 premature newborns received respectively strain eca, strain emo and both strains simultaneously. a fourth group was used as a control. resistant eos became spontaneously established in the digestive tract of a majority of the unadministe ... | 1990 | 2223912 |
| implantation and in vivo antagonistic effects of antibiotic-susceptible escherichia coli strains administered to premature newborns. | two antibiotic-susceptible and non-pathogenic escherichia coli strains were administered to hospitalized premature infants in order to protect them from intestinal colonization by hospital-acquired antibiotic-resistant enteric organisms (eos). three groups of 16 premature newborns received respectively strain eca, strain emo and both strains simultaneously. a fourth group was used as a control. resistant eos became spontaneously established in the digestive tract of a majority of the unadministe ... | 1990 | 2223912 |
| susceptibility of haemophilus influenzae to antimicrobial agents used in canada. canadian study group. | we evaluated the incidence of haemophilus influenzae resistance to selected antimicrobials used in canada. from 1985 to 1987, 2503 h. influenzae isolates obtained in 14 hospitals across canada were sent to the centre hospitalier de l'université laval (chul) for identification, serotyping, biotyping and testing for beta-lactamase production. susceptibility tests were done with the use of 12 antibiotics. of the strains 424 (16.9%) produced beta-lactamase; the proportion varied from 12.8%, in newfo ... | 1990 | 2224717 |
| comparative in vitro activity of cefpirome and cefepime, two new cephalosporins. | in in vitro tests the broad-spectrum cephalosporins cefpirome and cefepime were highly active against enterobacteriaceae, although often less so against strains resistant to amoxicillin-clavulanate and ticarcillin-clavulanate, and against most strains of acinetobacter spp. and aeromonas hydrophila. they were also active against pseudomonas aeruginosa, although strains with non-plasmid mediated beta-lactam resistance were sometimes less sensitive. other pseudomonas spp. varied in their sensitivit ... | 1990 | 2226498 |
| in vitro activity and beta-lactamase stability of the new oral cephalosporin bay v 3522. | the activity of the new oral cephalosporin bay v 3522 was compared to that of six other beta-lactam agents. bay v 3522 inhibited methicillin-susceptible staphylococcus aureus and staphylococcus epidermidis at less than or equal to 2 micrograms/ml, compared to mics of greater than or equal to 8 micrograms/ml for the other cephalosporins tested. it was more active against streptococcus pyogenes (mic less than or equal to 0.06 microgram/ml) than cefuroxime, cefixime, cephalexin and cefaclor. groups ... | 1990 | 2226499 |
| opsonic effect of jacalin and human immunoglobulin a on type ii group b streptococci. | this study examined the effect of immunoglobulin a (iga) and the iga-binding lectin jacalin on the phagocytosis of type ii group b streptococci (gbs). strains possessing the trypsin-sensitive and trypsin-resistant components of the c protein (ii/c) and type ii gbs lacking the c protein (ii) were examined by radiolabeled bacterial uptake, bactericidal assays, and electron microscopy. type ii/c gbs resisted phagocytosis by monocytes (4.9% +/- 0.8% uptake, mean +/- se, n = 25) compared with type ii ... | 1990 | 2228238 |
| abelson murine leukemia virus transforms preneoplastic emu-myc transgene-carrying cells of the b-lymphocyte lineage into plasmablastic tumors. | e mu-myc transgenic mice were back-crossed to balb/c mice up to back-cross generation 3. the offspring that included transgene-carrying and -negative mice in approximately equal proportions were randomly divided into 2 groups. thirty-four mice (group i) were treated with pristane, followed by a-mulv, and 40 (group ii) were injected with a-mulv alone. altogether, 16 lymphoid tumors developed in group i and 17 in group ii. nine of the tumors in group i and 4 in group ii appeared as ascitic tumors. ... | 1990 | 2228313 |
| a three year survey of clinical isolates in the united kingdom and their antimicrobial susceptibility. | a united kingdom national survey of clinical isolates and their antimicrobial susceptibility was performed, with 61 participating hospital laboratories, between 1986 and 1989. each centre used microbe base, a commercial suite of micro-computer programs which can record and analyse antimicrobial susceptibility data informative on 366,853 bacterial isolates and their antimicrobial susceptibility was received from hospital and domiciliary specimens; candida spp. accounted for a further 9121 isolate ... | 1990 | 2228831 |
| protein d of haemophilus influenzae. a novel bacterial surface protein with affinity for human igd. | protein d, a novel surface protein of the bacterial species haemophilus influenzae with affinity for human igd, was isolated after solubilization with sonication and sarcosyl-extraction by a single sds-page step. from 1 ml of packed bacteria was prepared 0.25 mg of purified protein d. the apparent m.w. of protein d was estimated to 42,000 by sds-page and gel chromatography. edman degradation cycles of protein d produced no amino acid phenylthiohydantoin derivatives and the amino-terminal end of ... | 1990 | 2230124 |
| cefuroxime treatment failure of nontypable haemophilus influenzae meningitis associated with alteration of penicillin-binding proteins. | a 10-year-old boy presented with nuchal rigidity and cerebrospinal fluid (csf) leukocytosis initially and again on day 6 of intravenous cefuroxime therapy (200 mg/kg/day). both csf specimens yielded nontypable beta-lactamase-negative haemophilus influenzae that were susceptible by disk tests but relatively resistant to cefuroxime (mic, 8- to 16-fold greater than that of control isolates). to define the mechanism of resistance, the cefuroxime resistance marker was transformed to a susceptible h. ... | 1990 | 2230238 |
| antibody affinity in infants after immunization with conjugated capsular polysaccharide from haemophilus influenzae type b. | the affinities of igg antibodies to haemophilus influenzae b capsular polysaccharide (polyribosyl ribitol phosphate [prp]) elicited 1 month after immunization of 47 infants 2-greater than 18 months of age with a prp-outer membrane protein conjugate (prp-omp) were measured by elisa. thirty-four sera had affinities distributed normally about a logarithmic mean of 3.2 x 10(5) l/mol, but 13 samples had undetectable affinities (less than 10(4) l/mol). median affinities of sera from children 2-6 (1.5 ... | 1990 | 2230242 |
| bacterial meningitis in the united states, 1986: report of a multistate surveillance study. the bacterial meningitis study group. | a prospective, laboratory-based surveillance project obtained accurate data on meningitis in a population of 34 million people during 1986. haemophilus influenzae was the most common cause of bacterial meningitis (45%), followed by streptococcus pneumoniae (18%), and neisseria meningitidis (14%). rates of h. influenzae meningitis varied significantly by region, from 1.9/100,000 in new jersey to 4.0/100,000 in washington state. the overall case fatality rates for meningitis were lower than those ... | 1990 | 2230261 |
| pancreatogastrostomy in experimental acute necrotizing pancreatitis. | experimental acute necrotizing pancreatitis was induced retrogradely in dogs with sunflower oil injected intraductally. then, a zipper was sutured into the abdominal wound. from the first postoperative day, three different treatments were started: first group: only conservative therapy was used; second group: removal of necrotized tissue and single peritoneal lavage were applied; and third group: the necrotic part of the pancreas was marsupialized into the stomach. through the systematic opening ... | 1990 | 2230363 |
| urogenital, maternal and neonatal isolates of haemophilus influenzae: identification of unusually virulent serologically non-typable clone families and evidence for a new haemophilus species. | a collection of 117 strains of haemophilus influenzae, including 112 non-typable isolates recovered predominantly in the usa and france from genital, obstetric and neonatal sources, was characterized by the electrophoretic mobilities of 10 metabolic enzymes. eighty-six distinctive multilocus chromosomal genotypes (electrophoretic types, ets) were distinguished on the basis of allele profiles at the enzyme loci. isolates of five allied biotype iv ets were highly divergent from all other strains a ... | 1990 | 2230714 |
| sertoli cell-secreted protein(s) stimulates dna synthesis in purified rat leydig cells in vitro. | we have examined the effects of sertoli cell-secreted proteins (scsp) on [3h]thymidine incorporation by purified preparations (greater than 96%) of rat leydig cells to determine whether sertoli cells influence dna synthesis in these cells in vitro. incubation of leydig cells isolated from testes of rats of ages 16 to 90 days with scsp (mr greater than 10,000) induced significant dose-, time- and age-related increases in [3h]thymidine incorporation by the cells. a dose-response curve to scsp show ... | 1990 | 2231558 |
| from the food and drug administration. | | 1990 | 2231988 |
| [a clinical study on ceftazidime in the treatment of intractable respiratory infections]. | ceftazidime (caz) was administered to 51 patients (37 males, 14 females) with respiratory infections including severe cases, accompanied by various underlying respiratory diseases. the clinical efficacy and side effects of caz were investigated. the mean age and body weight of these 51 cases were 62.6 years and 48.0 kg, respectively. caz was administered by intravenous drip infusion (daily dose of 2-4 g) for a mean of 14.7 days to a mean total dose of 56.7 g. clinical efficacy rates were 64% (18 ... | 1990 | 2232147 |
| [synergy between sulbactam and ampicillin or cefoperazone in antimicrobial activity against beta-lactamase producing microorganisms. results with the use of microdilution broth method]. | antimicrobial activities of sulbactam (sbt) with ampicillin (abpc) or with cefoperazone (cpz), in other words, the effects of sbt, an beta-lactamase inhibitor, against beta-lactamase producing strains of clinical isolates, were studied using microdilution broth method. 1. beta-lactamase producing strains such as staphylococcus aureus, branhamella catarrhalis, haemophilus influenzae, escherichia coli and klebsiella pneumoniae decompose benzylpenicillin (pcg) which is one of substrates of the acid ... | 1990 | 2232151 |
| a randomized, prospective field trial of a conjugate vaccine in the protection of infants and young children against invasive haemophilus influenzae type b disease. | haemophilus influenzae type b is the leading cause of invasive bacterial disease in young children. the capsular polysaccharide vaccine does not protect children at greatest risk (those under the age of 18 months), but a polysaccharide-protein conjugate vaccine has proved to be more immunogenic in this age group. | 1990 | 2233904 |
| impaired antibody response to haemophilus influenzae type b polysaccharide and low igg2 and igg4 concentrations in apache children. | because native american children are at much higher risk for invasive haemophilus influenzae type b infection than white children, we compared the antibody responses to h. influenzae type b polysaccharide vaccine in healthy apache and white children. | 1990 | 2233905 |
| limited efficacy of a haemophilus influenzae type b conjugate vaccine in alaska native infants. the alaska h. influenzae vaccine study group. | the prevention of invasive haemophilus influenzae type b disease requires a vaccine that is effective when administered during the first six months of life. the infants of alaska natives are at particularly high risk of invasive h. influenzae type b disease. | 1990 | 2233906 |
| evaluating the haemophilus influenzae type b conjugate vaccine prp-d. | | 1990 | 2233910 |
| the sequelae of haemophilus influenzae meningitis in school-age children. | previous data on the consequences of haemophilus influenzae type b meningitis for school-age children have been inconsistent, and much of the information on risk factors has been inconclusive. the present study was designed to evaluate the sequelae of this disease with a protocol for the comprehensive assessment of neuropsychological function. | 1990 | 2233963 |
| serum immunoglobulin levels and natural antibodies to haemophilus influenzae in hemodialysis patients: evidence for igg subclass imbalances. | humoral immune parameters were studied in 13 patients with end-stage renal failure on maintenance hemodialysis. serum iga, igm and igg concentrations were comparable to control values from 14 healthy blood donors. igg subclass analysis revealed significantly increased igg1 levels in the patients when compared to controls (p less than 0.01). in 3 patients, igg2 deficiency was found, in one case associated with low igg3 level. concentrations and subclass composition of naturally occurring antibodi ... | 1990 | 2234247 |
| [norfloxacin: a broad-spectrum quinolone for superficial eye infections]. | norfloxacin is a synthetic antibiotic belonging to the fluoroquinolone class. at present, an oral formulation is available and indicated for the treatment of urinary tract infections. because of the properties of norfloxacin, a 0.3% norfloxacin ophtalmic solution may be used by ophtalmologists. the molecular target of norfloxacin is dna gyrase that regulates dna replication. norfloxacin is a broad spectrum antibiotic. a flurin atome in position 6 is responsible for the broad spectrum of activity ... | 1990 | 2235090 |
| safety evaluation of prp-d haemophilus influenzae type b conjugate vaccine in children immunized at 18 months of age and older: follow-up study of 30,000 children. | we evaluated the safety of the prp-d conjugate hib vaccine (prohibit, connaught) in 29,309 children vaccinated at 18-60 months of age in the southern california kaiser permanente medical clinics during the period april 1, 1988, to july 31, 1989. surveillance for potential reactions involved postcard questionnaires, telephone surveys, reports of kaiser staff and review of hospitalizations and covered two periods following immunization: (1) the first 48 hours and (2) days 2 through 30. surveillanc ... | 1990 | 2235171 |
| haemophilus influenzae type b abscess after diphtheria-tetanus toxoids-pertussis immunization. | | 1990 | 2235180 |
| immunogenicity of haemophilus b conjugate vaccine (meningococcal protein conjugate) in children with prior invasive haemophilus influenzae type b disease. | children younger than 2 years of age with previous invasive haemophilus influenzae (hib) type b disease may not develop protective antibodies to antigens of hib and may be at risk of developing a second episode of hib disease. twenty-three children with prior hib disease were immunized with haemophilus b conjugate vaccine (meningococcal protein conjugate). children 12 to 24 months of age were given one dose of vaccine and children younger than 12 months of age were given 2 doses 2 months apart. ... | 1990 | 2235187 |
| haemophilus influenzae type b resistant to ampicillin and chloramphenicol. | | 1990 | 2235198 |
| american academy of pediatrics committee on infectious diseases: haemophilus influenzae type b conjugate vaccines: immunization of children at 15 months of age. | | 1990 | 2235237 |
| [bacterial meningitis in iceland]. | the article reports on the number of patients in iceland who in the last 30 years have been diagnosed as having bacterial meningitis, and on changes in the choice of medication during this period. the vaccination of icelandic children against haemophilus influenzae b began in 1989. | 1990 | 2235469 |
| antibacterial and mutagenic activity of inhaled bronchodilators on the respiratory pathogen haemophilus influenzae. | the u.k. prevalence of non-beta-lactamase-mediated resistance to ampicillin among haemophilus influenzae reached 4% in 1986. the majority (70%) of isolates of this type come from sputa of patients with chronic obstructive airways disease. this study investigated whether bronchodilator drugs delivered directly to the respiratory tract have any antibacterial activity and/or play a role in promoting selection of organisms with this type of resistance. antibacterial activity was detected in two out ... | 1990 | 2236759 |
| [septic arthritis due to haemophilus influenzae in adults]. | | 1990 | 2236777 |
| bacterial tracheitis: report of eight new cases and review. | bacterial tracheitis, previously referred to as nondiphtheritic laryngitis with marked exudate, was commonly discussed in pediatric textbooks before 1940. it seemed to disappear as a clinical entity after that time, but it has been recorded with increasing frequency in the pediatric literature since 1979. we describe eight new cases and review 110 previously described cases. the clinical course consists of a prodromal upper respiratory illness with stridor, fever, and a variable degree of respir ... | 1990 | 2237109 |
| [haemophilus influenzae type b infections: epidemiology, prospects for vaccination]. | | 1990 | 2237226 |
| haemophilus influenzae and streptococcus pneumoniae in children with acute respiratory infection. | the incidence of haemophilus influenzae and streptococcus pneumoniae in children with acute respiratory infection (ari) under 5 years was carried out by throat swab culture, blood culture, body fluid or tissue culture in 688 patients from a community, 744 patients from a teaching hospital in bangkok, 766 normal children from the community and 303 children from a hospital well baby clinic. h. influenzae was found in the throats of 15-20% of patients and in the throats of 4-6% of normal children ( ... | 1990 | 2237586 |
| evaluation of bcg at birth in the united arab emirates. | a total of 387 healthy full term infants who received bcg vaccination at birth were evaluated by the tuberculin ppd test at 6-8 weeks post vaccination. a total of 92% of these infants had visible bcg scars at that time. all infants were tested with ppd but only 264 returned for the test to be read. the tuberculin test was negative in 37 (14%) and of less than 5 mm induration in another 60 (23%) of the infants. the same pattern was observed in different nationalities. of 11 infants with no bcg sc ... | 1990 | 2238123 |
| evaluation of bcg at birth in the united arab emirates. | a total of 387 healthy full term infants who received bcg vaccination at birth were evaluated by the tuberculin ppd test at 6-8 weeks post vaccination. a total of 92% of these infants had visible bcg scars at that time. all infants were tested with ppd but only 264 returned for the test to be read. the tuberculin test was negative in 37 (14%) and of less than 5 mm induration in another 60 (23%) of the infants. the same pattern was observed in different nationalities. of 11 infants with no bcg sc ... | 1990 | 2238123 |
| [selective screening for hypercholesterolemia. results from a screening model in general practice]. | at present, it appears to be probable that both dietary changes and medicinal treatment can reduce the risk of development of coronary disease in middle-aged men with moderately to severely raised blood cholesterol values. internationally, the limits for cholesterol intervention are considerably lower than in denmark. extensive cholesterol screening is, however, very expensive and the identified persons with high cholesterol values will frequently be found in sex and age groups where the benefic ... | 1990 | 2238223 |
| [selective screening for hypercholesterolemia. results from a screening model in general practice]. | at present, it appears to be probable that both dietary changes and medicinal treatment can reduce the risk of development of coronary disease in middle-aged men with moderately to severely raised blood cholesterol values. internationally, the limits for cholesterol intervention are considerably lower than in denmark. extensive cholesterol screening is, however, very expensive and the identified persons with high cholesterol values will frequently be found in sex and age groups where the benefic ... | 1990 | 2238223 |
| [effect of enalapril on heart rate, arterial blood pressure and exocrine pancreatic secretion in the alert dog]. | a changed exocrine pancreatic secretion could be a pathogenetic factor of an acute pancreatitis after administration of angiotensin-converting enzyme (ace) inhibitors. in six conscious dogs with gastric and duodenal thomas fistulas we studied the effect of an intravenous (iv.) bolus injection of 10 mg enalaprilat, an intraduodenal (id.) bolus injection of 20 and 40 mg enalapril (e.), and 0.15 m nacl (20 ml iv., resp., id.) on pancreatic bicarbonate- and protein output in response to secretin (20 ... | 1990 | 2238764 |
| [bone healing--an immunoreactive process?]. | cell mediated immune reactions, demonstrated by leukocyte migration assay and histological analysis of spleen and lymph nodes, could be observed after fresh autografting of cortical segments in rats. the detected immune answer showed a bone-specific reaction pattern. in consideration of the temporal correlation of the observed immune reactions and the histological signs of graft incorporation, a connection of bone healing and immune system may be possible. | 1990 | 2238978 |
| [bone healing--an immunoreactive process?]. | cell mediated immune reactions, demonstrated by leukocyte migration assay and histological analysis of spleen and lymph nodes, could be observed after fresh autografting of cortical segments in rats. the detected immune answer showed a bone-specific reaction pattern. in consideration of the temporal correlation of the observed immune reactions and the histological signs of graft incorporation, a connection of bone healing and immune system may be possible. | 1990 | 2238978 |
| bacteremia in an ambulatory setting. improved outcome in children treated with antibiotics. | we undertook a study of 414 bacteremic patients (167 with haemophilus influenzae and 247 with streptococcus pneumoniae bacteremia) to evaluate their clinical presentation, laboratory and clinical results, and subsequent outcomes. patients with h influenzae bacteremia were more likely to have soft-tissue foci, poorer clinical appearance at presentation, and be at higher risk for subsequent serious focal infections, persistent bacteremia, and subsequent hospital admissions than patients with s pne ... | 1990 | 2239857 |
| day care characteristics associated with haemophilus influenzae disease. haemophilus influenzae study group. | to identify characteristics of day care facilities associated with h. influenzae disease, we compared 92 licensed facilities in which a case of h. influenzae disease had occurred with randomly selected facilities at which no cases occurred. matched univariate analysis showed that personnel at facilities where h. influenzae disease occurred were more likely than those at control facilities to use towels or handkerchiefs to wipe children's noses, admit children who were not toilet trained or had d ... | 1990 | 2240329 |
| splenectomy in compound heterozygous hemoglobinopathies in saudi arabia. | hemoglobinopathies are a major public health problem in saudi arabia. we studied the effect of splenectomy in 16 saudi arabian children with compound hemoglobinopathies. seven patients no longer require regular blood transfusions, and transfusion requirements were decreased by 30 to 60% in the other eight patients. three patients whose heights and weights were below the 5th percentile before splenectomy reached the 25th percentile 1 year after the surgery. in spite of preoperative pneumococcal v ... | 1990 | 2240476 |
| staphylococcus aureus in atopic dermatitis and in nonatopic dermatitis. | skin colonization with staphylococcus aureus (s. aureus) was examined in 30 patients with atopic dermatitis (ad), in 25 patients with nonatopic eczema (nae) and in 30 individuals as healthy controls (hc). bacteria growth was examined in aerobic cultures and the population densities per dish were estimated; s. aureus colonization was found in the eczematous skin of 24 of 30 (80%) ad patients and in 13 of 25 (52%) nae patients (ns, p greater than 0.1). in nonaffected skin s. aureus colonization wa ... | 1990 | 2242947 |
| routine screening for potential babesicides using cultures of babesia bovis. | a procedure for screening of potential anti-malarial agents, based on the incorporation of [3h]hypoxanthine by the parasite, was adapted for the testing of anti-metabolites against babesia bovis (lismore and samford isolates) cultured in vitro. a close correlation was found between [3h]hypoxanthine incorporation in a standard assay and percentage of parasitized cells as determined by microscopic examination. the concentrations of compounds causing 50% inhibition of [3h]hypoxanthine incorporation ... | 1990 | 2242963 |
| [studies on respiratory infections in primary care clinic (iii). distribution of bacteria isolated from patients with respiratory infections visiting 21 private clinics in the tohoku district of japan]. | the bacteriology of the isolates from the throat swab and the sputum respectively of 2,539 patients with respiratory infections visiting 21 private clinics in tohoku district of japan during the period from january to april in 1989 was documented. of the 2,539 patients, 1,694 had an acute upper respiratory infection, 609 had acute bronchitis, 46 had acute pneumonia, 84 had acute exacerbation of chronic respiratory infections and 106 had respiratory infections without diagnosis registered. 1887 ( ... | 1990 | 2243193 |
| [studies on respiratory infections in primary care clinic (iv). antibiotic sensitivity of bacteria isolated from patients with respiratory infections visiting 21 private clinics in the tohoku district of japan]. | we determined the mics of ampicillin, methicillin, cefaclor, cefixime, cefteram, ofloxacin and ciprofloxacin against a total of 1,448 strains from 11 species: 464 strains of staphylococcus aureus, 306 strains of streptococcus pneumoniae, 114 strains of streptococcus pyogenes, 37 strains of branhamella catarrhalis, 329 strains of haemophilus influenzae, 32 strains of escherichia coli, 66 strains of klebsiella pneumoniae, 26 strains of enterobacter cloacae, 20 strains of serratia marcescens, 12 st ... | 1990 | 2243194 |
| evaluation of a selective medium for the isolation and differentiation of haemophilus influenzae and haemophilus parainfluenzae from the respiratory tract of chronic bronchitics. | respiratory tract specimens from chronic bronchitic patients were cultured for haemophilus species on conventional chocolate agar and a modified sucrose medium in order to determine the accuracy of the new medium in differentiating haemophilus influenzae from haemophilus parainfluenzae strains. haemophilus influenzae biotypes ii and iii and haemophilus parainfluenzae biotypes i and ii were found to be the predominant strains isolated from the respiratory tract. the modified sucrose medium was fo ... | 1990 | 2243729 |
| controversies in the treatment of streptococcal pharyngitis. | an increasing number of cases of sore throat caused by group a beta-hemolytic streptococci occur with concomitant colonization by organisms that may "protect" the streptococci through beta-lactamase inactivation of penicillin at the site of infection. the failure of penicillin to eradicate many of these bacteria, which include staphylococcus aureus, haemophilus influenzae, moraxella (branhamella) catarrhalis and a multitude of pharyngeal anaerobes, may help to explain why penicillin is sometimes ... | 1990 | 2244548 |
| postexposure prophylaxis. the u.s. preventive services task force, washington, d.c. | | 1990 | 2244551 |
| spectrum of invasive haemophilus influenzae type b disease in adults. | a prospective nationwide surveillance of invasive haemophilus influenzae type b disease among adults (greater than or equal to 16 years old) was conducted in finland during 1985 through 1988. thirty-one cases were identified (annual incidence, 0.22/100,000). of these infections, 71% occurred in patients with severe underlying conditions. the overall case fatality rate was 26%. septicemia (13 patients) and pneumonia (seven patients) were the most common clinical manifestations of h influenzae typ ... | 1990 | 2244774 |
| analysis of immunosuppressive molecules associated with murine in vitro fertilized embryos. | supernatants from mouse in vitro fertilized (ivf) oocyte cultures may suppress in vitro lymphocyte proliferation stimulated by concanavalin a (sigma, st. louis, mo). supernatants conditioned by incubation with mouse epididymal sperm alone were even more inhibitory. thin-layer chromatography suggested the polyamines spermine in sperm and spermine plus spermidine in ivf embryo supernatants were responsible. putrescine was not suppressive. in vitro fertilized oocytes from old cba/j-strain mice (gre ... | 1990 | 2245843 |
| changes in tonsillar bacteriology of recurrent acute tonsillitis: 1980 vs. 1989. | recurrent acute tonsillitis is a common problem. despite this, there still remain many controversies regarding aetiology and correct management. the tonsillar microflora of 33 children with recurrent acute tonsillitis studied in 1980 and 58 patients studied in 1989 is presented. a comparison of the microbiology in the two periods studied a decade apart suggests that the pathogenic profile is changing. haemophilus influenzae increased from 39 to 62% in the deep tonsillar tissue in the decade. the ... | 1990 | 2247668 |
| nurse infected with hiv virus urges others to take care. | | 1990 | 2248321 |
| cefpodoxime: comparable evaluation with other orally available cephalosporins. with a note on the role of beta-lactamases. | the antibacterial activity of cefpodoxime, a new orally active methoxy-imino cephalosporin was evaluated in 470 recent isolates of gram-positive cocci and gram-negative rods from clinical specimens and compared to that of other orally active beta-lactam compounds. cefpodoxime was highly active against ampicillin-resistant enterobacteria producing the plasmid-mediated tem-1, tem-2 or oxa-1 enzymes, as was the case for the other newer compounds. however, it was poorly active against cefuroxime-res ... | 1990 | 2248685 |
| study of the antigenic relationships between strains of bacteroides, intermedius, b. melaninogenicus, b. corporis, and b. denticola revealed by immunoblotting with rabbit antisera. | antigen profiles of saccharolytic oral black-pigmented bacteroides have been developed by western blotting. visual comparisons indicated extensive cross-reactions between b. intermedius, b. melaninogenicus, b. denticola, and b. corporis. porphyromonas gingivalis, p. asaccharolyticus, and b. buccae showed less cross-reaction. quantitation of antigenic similarity was made from densitometric scans. calculation of the jackard coefficient gave results of 33-72% similarity among the saccharolytic pigm ... | 1990 | 2249172 |
| sternoclavicular septic arthritis due to haemophilus influenzae. | we have reported a case of septic sternoclavicular arthritis illustrating a rare complication of infection with a relatively common pathogen, haemophilus influenze. early identification of the infecting organism and appropriate antibiotic therapy are essential to prevent further morbidity from the complications of this unusual pyoarthritis. | 1990 | 2251538 |
| a rat model of prolonged pulmonary infection due to nontypable haemophilus influenzae. | pulmonary colonization and infection with nontypable (unencapsulated) haemophilus influenzae (nthi) occurs commonly in the setting of chronic lung diseases. because the study of nthi pulmonary infection in animal models has been limited by the rapid clearance of organisms, a model of persistent pulmonary infection was developed. groups of rats were inoculated by transtracheal instillation of viable nthi suspended in broth or semisolid agar. some rats had received hexamethylphosphoramide (hmp) in ... | 1990 | 2252263 |
| regulation of nicotinic acetylcholine receptor function by adenine nucleotides. | 1. nicotinic acetylcholine receptors (nachr)4 from bc3h1 cells (which express a skeletal muscle-type receptor) and from torpedo californica electric organ were expressed in xenopus laevis oocytes and studied with a voltage-clamp technique. 2. we found that bath application of atp in the micromolar to millimolar range increased the ach-elicited current in both muscle and electrocyte receptors. the effect of atp increased with successive applications. this "use-dependent" increase in potentiation ... | 1990 | 2253264 |
| effects of chronic treatment of mptp monkeys with bromocriptine alone or in combination with skf 38393. | eight monkeys developed a severe parkinsonian syndrome after i.v. administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). treatment with bromocriptine (5 mg/kg) relieved the parkinsonian symptoms, but the efficacy of this treatment appeared to decrease slightly with time. the addition of skf38393 (5 mg/kg) to the bromocriptine treatment in four monkeys prevented and even reversed the tendency to decreased efficacy with an increased response in three out of four animals. neither of ... | 1990 | 2253695 |
| haemophilus influenzae adheres to and enters cultured human epithelial cells. | haemophilus influenzae is a common commensal organism of the human respiratory tract that initiates infection by colonizing the nasopharyngeal epithelium. in some individuals, colonization is followed by localized respiratory tract or systemic disease. to gain insight into the mechanisms by which h. influenzae attaches to and persists within the nasopharynx, we examined the interactions between a nonpiliated clinical isolate of h. influenzae and human epithelial cells. we noted substantial adher ... | 1990 | 2254028 |
| antimicrobial susceptibility testing of haemophilus influenzae. improvement of accuracy of the disc diffusion test. | a national quality control study was performed in 1986 to investigate the standard of performance of the disc diffusion antimicrobial susceptibility testing of haemophilus influenzae in sweden. the accuracy of susceptibility interpretations was unacceptably low. a new standardized method for susceptibility testing of h. influenzae was then worked out, and a new method of setting interpretive zone breakpoints was introduced. the susceptibility category of the main population of clinical isolates ... | 1990 | 2254221 |
| in vitro and in vivo anticancer activity of mitozolomide and sparsomycin in human tumor xenografts, murine tumors and human bone marrow. | the colony formation in agar of human tumor xenografts, of murine tumors and of human bone marrow was used as a test system to determine the in vitro activity of the two novel cytostatic agents, mitozolamide and sparsomycin. mitozolomide was additionally studied in vivo in nine human tumor xenografts. the comparison of in vitro/in vivo activity allows an assessment of the relevant in vitro dose based on in vivo pharmacological behavior of a compound. both compounds showed clear dose/response eff ... | 1990 | 2254373 |
| the epidemiology of invasive haemophilus influenzae infections in children under five years of age in the northern territory: a three-year study. | a survey of all episodes of invasive haemophilus influenzae infections that were diagnosed over a three-year period in children seen at the regional hospitals of the northern territory has found a significantly (p less than 0.001) higher incidence in children in central australia (the alice springs and barkly regions, and the anangu pitjantjatjara lands) than in the top end (the darwin, east arnhem and katherine regions), and a greater incidence in aboriginal than in non-aboriginal children. ide ... | 1990 | 2255282 |
| [bacterial resistance against beta-lactam antibiotics]. | beta-lactam antibiotics include the penicillins, cephalosporins, oxacephems (moxalactam), carbapenems (imipenem) and monobactams (azthreonam)--all with a common beta-lactam ring. beta-lactam antibiotics block the synthesis and growth of the bacterial cell wall by binding to penicillin-binding proteins on the cytoplasma membrane. the bacteria may escape the effect of beta-lactam antibiotics by reducing the permeability of the cell wall (gramnegative bacteria), by producing beta-lactamases, by red ... | 1990 | 2256036 |
| [prosthesis-endocarditis in the aortic position in a 22-year case load. surgical versus conservative treatment]. | during the period 1965-1986, a total of 852 patients underwent isolated aortic valve replacement. with 4,875 patients-years at risk, 24 patients developed prosthetic valve endocarditis (pe; 0.49% per patient-year). the five, ten and fifteen year cumulative freedoms from pe were 98.2%, 95.4% and 93.0%, respectively. pe was unrelated to pre- or intraoperative data. no patients submitted to operation for acute/subacute bacterial endocarditis of the native aortic valve developed pe. out of the 12 ep ... | 1990 | 2256222 |
| vaccine prevention of haemophilus influenzae type b disease. | | 1990 | 2257177 |
| lymphoid dendritic accessory cells of the rat. | the expression of mhc class ii antigens on potential apc is a crucial step in t-lymphocyte activation and the initiation of an immune response. the studies which are presented here were initiated to characterize the critical apc present in physiologically normal, untreated rats. such a cell should constitutively express these antigens at high density and therefore provide the apparatus necessary to provoke both primary and secondary immune responses at any time. dac were found to fulfill these c ... | 1990 | 2258188 |
| human breast-cancer growth and progression: role of secreted polypeptide growth factors. | | 1990 | 2258267 |
| pefloxacin therapy for nosocomial infections in the intensive care unit. | nosocomial infections occurring in an intensive care unit (icu) are commonly caused by aerobic gram-negative bacilli or staphylococcus aureus, which are frequently multi-resistant and difficult to treat and contribute significantly to the patients' morbidity in the icu. pefloxacin, with its wide range of antimicrobial activity, lack of serious side-effects and advantageous kinetics, is a useful drug for use in this group of critically ill patients. pefloxacin has achieved a greater than 70% clin ... | 1990 | 2258356 |
| detection of haemophilus influenzae in cerebrospinal fluids by polymerase chain reaction dna amplification. | two primer sets were chosen for the detection of haemophilus influenzae in cerebrospinal fluid by polymerase chain reaction (pcr) dna amplification. one primer set was selected from sequences encoding a capsulation-associated protein and reacted with target dna from all 15 capsulate h. influenzae strains (all serotypes) examined. the other primer set was selected from the dna sequence of a gene encoding for outer-membrane protein p6 and reacted with the 15 capsulate and 10 non-capsulate strains ... | 1990 | 2258914 |
| tardive eating dystonia. | after cessation of long-term treatment with haloperidol, a 77-year-old man developed severe dyskinetic-dystonic movements involving mainly the tongue and associated also with oromandibular dystonia and blepharospasm that were manifested exclusively during the process of eating and that interfered with feeding. there were no spontaneous involuntary movements nor were they apparent during any other simple or complex activations of the orofacial musculature. | 1990 | 2259358 |
| [microbiologic aspects of bacteremia in patients hospitalized in the intensive care unit]. | the microbiologic aspects of the bacteriemia were prospectively studied in patients hospitalized in a pediatric intensive care unit. thirty six episodes of bacteriemia were detected in 29 patients. secondary bacteriemia prevailed on the primary ones. the most frequent infectious foci associated with bacteriemia were the infections of respiratory tract, followed by intravascular catheterism. the microorganisms more frequently associated with bacteriemia were: haemophilus influenzae, staphylococcu ... | 1990 | 2259780 |
| rapid aetiological diagnosis of pneumonia based on routine laboratory features. | the values of some basic laboratory features on admission to hospital were recorded and compared in 418 adult patients with community-acquired pneumonia, namely erythrocyte sedimentation rate, c-reactive protein, white blood cell (wbc) count, serum lactate dehydrogenase (s-ld), serum alanine-aminotransferase, and serum sodium. discriminant analysis was performed to obtain an aetiological diagnosis. wbc value of greater than 15 x 10(9)/l strongly indicated a bacterial and, especially a pneumococc ... | 1990 | 2259862 |
| increase of acute frontal sinusitis in southwestern finland. | the number of patients hospitalized for acute infection in the frontal sinuses at the department of oto-rhino-laryngology of turku university hospital has increased markedly during the last decade. causes for this increase were evaluated by comparing the backgrounds and medical findings of the 134 patients treated in the years 1977-81 and those of the 421 patients treated in the years 1982-86. nasal polyps and history of allergic rhinitis were considerably more common in the latter patient group ... | 1990 | 2259865 |
| comparative in vitro activity of the new oral cephalosporin bay v 3522 against aerobic and anaerobic bacteria. | the in vitro activity of the new oral cephalosporin bay v 3522 against 229 aerobic and 330 anaerobic clinical isolates was determined using the agar dilution technique. for comparison, amoxicillin, amoxicillin/clavulanate, cefaclor, cefadroxil, cefuroxime, cephalexin, ciprofloxacin, clindamycin, co-trimoxazole, doxycycline, erythromycin and metronidazole (only anaerobic bacteria) were tested. bay v 3522 was found to have high activity against staphylococcus aureus, staphylococcus epidermidis, en ... | 1990 | 2261923 |
| haemophilus influenzae lobar pneumonia in the father of a child with epiglottitis. | we present a case of haemophilus influenzae lobar pneumonia in the father of a child admitted with acute epiglottitis caused by the same organism. the suggestion that adult, as well as child, contacts for haemophilus influenzae epiglottitis should be prophylactically treated is discussed. | 1990 | 2261974 |
| [clinical laboratory approach to estimate effective administrative dose of minocyclin. reevaluation of in vitro mic break points in disc susceptibility test]. | antimicrobial activities of minocycline (mino) against various clinical isolates, 270 strains obtained in 1988, were determined and the reliability of the mino disc susceptibility test in estimating approximate values of mics was studied. clinical significance of a 4 category system for the interpretation of the disc tests, which is widely used in japan, and that of a 3 category system used in the usa and europe, were also evaluated to determine which system would be more suitable for the evalua ... | 1990 | 2262962 |
| [ways of improving the effectiveness of bacteriological diagnosis and treatment of nonspecific lung diseases]. | isolation, identification and drug sensitivity assay of microorganisms from pathological materials of 177 patients with nonspecific diseases of the lungs, mainly pneumonia, were performed on blood and selective "chocolate" agars by using baktofok-mk, a new dry nutrient basis developed by the authors. blood and "chocolate" agars based on the hottinger's hydrolysate were used as the control media. it was shown that with the quantitative procedure for inoculating the pathological material, the expe ... | 1990 | 2264754 |
| the effect of transforming growth factor-beta on the alkaline phosphatase activity in rabbit renal cortical tubular cell cultures. | the effect of various growth regulators including epidermal growth factor and transforming growth factor-beta on the alkaline phosphatase activity of rabbit renal cortical tubular cells has been investigated in a serum-free culture. as a result, it was found that transforming growth factor-beta, known to be a growth inhibitor of renal tubular cells, increased the alkaline phosphatase activity of the tubular cells dose-dependently and that cycloheximide blocked any increase in the activity of thi ... | 1990 | 2265430 |
| invasive haemophilus influenzae infections among children in rochester, minnesota: a population-based study. | the incidence of invasive haemophilus influenzae infections was studied among all residents of rochester, minnesota, under 20 years of age during the period 1975-1983. the incidence in children under 5 years of age was 115 and 64 cases per 100,000 children per year for all invasive cases and for meningitis, respectively. these rates are among the highest reported for an essentially all-caucasian population in the united states, while the ratio of meningitis to non-meningitis cases (1.1:1) is amo ... | 1990 | 2267187 |
| pneumocystis carinii pneumonia in danish piglets. | | 1990 | 2267715 |