| role of human papillomavirus in the clinical and histopathologic features of laryngeal and hypopharyngeal cancers. | in this study, we aimed to evaluate the role of human papillomavirus (hpv) in the clinical and histopathologic features of laryngeal and hypopharyngeal cancers. | 2009 | 19344621 |
| the epidemiology of anal human papillomavirus and related neoplasia. | the relationship between cervical cancer and human papillomavirus (hpv) is well known. like cervical cancer, anal cancer is preceded by a series of precancerous changes, raising the possibility that like cervical cancer, anal cancer can be prevented. further, given the known risk factors for anal cancer, prevention efforts could be targeted to high-risk groups, providing a unique example of a screening program targeted to high-risk individuals. this article describes the epidemiology of anal hpv ... | 2009 | 19344856 |
| mechanisms of decreased expression of transforming growth factor-beta receptor type i at late stages of hpv16-mediated transformation. | transforming growth factor-beta (tgf-beta) signaling is disrupted in many cancers, including cervical cancer, leading to tgf-beta resistance. although initially sensitive, human papillomavirus type 16 (hpv16) immortalized human keratinocytes (hkc/hpv16) become increasingly resistant to the growth inhibitory effects of tgf-beta during in vitro progression to a differentiation resistant phenotype (hkc/dr). we have previously shown that loss of tgf-beta sensitivity in hkc/dr is attributed to decrea ... | 2009 | 19344999 |
| adolescent girls' attitudes on human papillomavirus vaccination. | the objective of the study was to assess the attitudes of adolescent girls on human papillomavirus (hpv) vaccination and the impact of an information pamphlet on their attitude. other factors that may affect their attitude were also studied. | 2009 | 19345913 |
| genetic variation in the vitamin c transporter, slc23a2, modifies the risk of hpv16-associated head and neck cancer. | human papillomavirus (hpv) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (hnscc). it is unknown if host genetic susceptibility modifies the hpv16-hnscc association. dna samples collected as part of a boston area case-control study of hnscc were genotyped for single-nucleotide polymorphisms (snps) from the national cancer institute's snp500cancer database. analysis of demographic, phenotypic and genotypic data for 319 hnscc cases and 495 frequency- ... | 2009 | 19346260 |
| role of molecular markers and gene profiling in head and neck cancers. | to explore the current status of molecular markers in the diagnosis, prognosis, and treatment of squamous cell carcinoma of the head and neck. | 2009 | 19346943 |
| geographic variation in the prevalence of kaposi sarcoma-associated herpesvirus and risk factors for transmission. | the aim of the present study was to estimate the prevalence of kaposi sarcoma-associated herpesvirus (kshv) in the female general population, to define geographic variation in and heterosexual transmission of the virus. | 2009 | 19351262 |
| cost-effectiveness evaluation of a quadrivalent human papillomavirus vaccine in belgium. | the introduction of a quadrivalent human papillomavirus (hpv; types 6, 11, 16, 18) vaccine is expected to significantly reduce the burden of cervical cancer, cervical intraepithelial neoplasia (cin), genital warts and other hpv-related diseases. | 2009 | 19354343 |
| molecular tests for human papillomavirus (hpv), chlamydia trachomatis and neisseria gonorrhoeae in liquid-based cytology specimen. | laboratory detection of human papillomavirus (hpv), chlamydia trachomatis and neisseria gonorrhoeae in liquid-based cervicovaginal cytology specimens is now based on identification of the dna sequences unique to these infectious agents. however, current commercial test kits rely on nucleotide probe hybridization to determine dna sequences, which may lead to diagnostic errors due to cross-reactivity. the aim of this study was to find a practical approach to perform automated sanger dna sequencing ... | 2009 | 19358733 |
| human papillomavirus 58 in a squamous cell carcinoma of the tongue. | | 2009 | 19362048 |
| cost-effectiveness of human papillomavirus vaccination in belgium: do not forget about cervical cancer screening. | the cost-effectiveness of adding a human papillomavirus (hpv) vaccination program in 12-year-old females to the recommended cervical cancer screening in belgium is examined. moreover, the health and economic consequences of a potential decline in screening uptake after initiation of a hpv vaccination program are investigated. | 2009 | 19366497 |
| potent anti-hpv immune responses induced by tandem repeats of the hpv16 l2 (20 -- 38) peptide displayed on bacterial thioredoxin. | the minor capsid protein l2 is a promising candidate for the construction of an anti-human papillomavirus (hpv) broadly protective vaccine for the prophylaxis of cervical cancer. however, l2-derived peptides are usually poorly immunogenic and extensive knowledge on the most relevant (cross)neutralizing epitope(s) is still needed. we systematically examined the immunogenicity and virus neutralization potential of six peptides encompassing the n-terminal (amino acids 1 -- 120) region of hpv16 l2 ( ... | 2009 | 19368776 |
| usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung. | to date, there is no reliable immunohistochemical marker that discriminates between primary pulmonary squamous cell carcinoma (scc) and cervical scc metastatic to the lung. in this study, immunohistochemical staining of p16 was performed on 33 primary pulmonary sccs, 48 primary cervical sccs, and 17 cases of cervical scc with pulmonary metastasis. expression of p16 was noted in 47 cases of cervical scc (47/48 [98%]), and all were strongly stained. of the 7 cases of primary pulmonary scc (7/33 [2 ... | 2009 | 19369633 |
| papanicolaou screening behavior in mothers and human papillomavirus vaccine uptake in adolescent girls. | we investigated whether maternal attitude toward prevention, as indicated by history of seeking papanicolaou (pap) tests and contracting sexually transmitted infections, influenced human papillomavirus (hpv) vaccine uptake among their adolescent daughters. | 2009 | 19372507 |
| p16 ink4a is a strong biomarker for cervical intraepithelial neoplasia and invasive cervical carcinoma: a reappraisal. | to assess the role of p16( ink4a), bcl-2, and p53 in cervical cancer screening, we conducted a retrospective trial of prospectively collected data. sixty two women with abnormal pap smears were subjected to colposcopy and biopsies from any abnormal lesion. human papillomavirus (hpv)-dna typing, histology, and immunochemistry for p16(ink4a), bcl-2, and p53 were performed for these women. histologic diagnosis was that of low grade squamous intraepithelial lesion (lsil), high grade squamous intraep ... | 2009 | 19372590 |
| [protection against uterine cervical cancer by hpv vaccines]. | research literature has definitively shown hpv to be a necessary cause of cervical cancer. hpv is highly prevalent in sexually active populations and its natural history is now traceable thanks to recent advances in technology. hpv-like particle can now be synthesized and assembled in vitro to constitute the major virion protein l1, and this technology has been exploited to produce hpv-l1-vlp vaccines. now, hpv-related diseases can thus be prevented by commercially available hpv prophylactic vac ... | 2008 | 19374193 |
| annual report: surveillance of adverse events following immunisation in australia, 2007. | this report summarises australian passive surveillance data for adverse events following immunisation (aefi) reported to the therapeutic goods administration for 2007, and describes reporting trends over the 8-year period 2000 to 2007. there were 1,538 aefi records for vaccines administered in 2007. this is an annual aefi reporting rate of 7.3 per 100,000 population, the highest since 2003 and an 85% increase compared with 2006 (835 aefi records; 4.0 records per 100,000 population). the increase ... | 2008 | 19374268 |
| modulation of apoptosis by early human papillomavirus proteins in cervical cancer. | cervical cancer (cc) constitutes a major women health problem. clinical, molecular, and epidemiological investigations have identified persistent infection with high risk human papillomavirus (hr-hpv) as the major cause of cc. hr-hpvs lead to development of cervical carcinoma, predominantly through the action of e5, e6 and e7 viral oncoproteins. after hr-hpv infection, viral proteins employ strategies to modulate apoptosis. the e2 viral protein induces apoptosis in both normal and hpv-transforme ... | 2010 | 19374936 |
| colposcopy to evaluate abnormal cervical cytology in 2008. | the rates of cervical cancer in the united states are low in comparison with developing nations. whereas the papanicolaou smear has performed well in terms of detecting both precursors of squamous cell carcinoma and squamous cell carcinoma of the cervix, this test has been less successful at identifying those women with the highest-risk premalignant disease. the use of human papillomavirus testing has also contributed to the improved sensitivity of screening for cervical cancer. in light of this ... | 2009 | 19375565 |
| detection of human papillomavirus infection in women attending a colposcopy clinic. | infection by human papillomavirus (hpv) is the main cause of and a necessary factor for cervical cancer. there are more than 100 known hpv genotypes, although hpv genotypes do not all have the same risk of inducing cervical cancer. the main aim of this study is to know the distribution of different types of hpv in women attending a colposcopy clinic for cervical dysplasia. | 2009 | 19376675 |
| acceptance of the hpv vaccine for adolescent girls: analysis of state-added questions from the brfss. | previous research regarding human papillomavirus (hpv) awareness and vaccine acceptance has relied on convenience or other selected samples of the population. to assess the prevalence of hpv awareness and vaccine acceptance in kentucky we added questions to the 2006 kentucky behavioral risk factor survey system (brfss), a population-based survey of health behaviors. | 2009 | 19380090 |
| [focal epithelial hyperplasia of the oral mucosa. a unique manifestation of human papillomavirus]. | a 34-year old creole woman appeared at the dermatology department with white-pink spots on the oral mucosa, which had been there for some time. histology showed lesions characteristic of focal epithelial hyperplasia. the patient was treated with a co2 laser. focal epithelial hyperplasia is a rare benign lesion and is caused by human papillomavirus subtypes 13 or 32; it only appears on the oral mucosa. | 2009 | 19382543 |
| human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of e6 and e7. | from 1970 to 2002 in the stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (hpv) positive tonsillar cancer cases, indicating a possible role of hpv infection in this disease. we have now examined whether hpv and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of hpv-16 e6 and e7 mrna could be ascertained. the presence of hpv-16, but not viral lo ... | 2007 | 19383307 |
| the hpv vaccines--which to prefer? | this review presents an unbiased comparison between the two vaccines available against human papillomavirus (hpv). we conducted a pubmed and google search for the years 1998 to october 2008 using the terms: cervical cancer vaccine, hpv vaccine, gardasil, and cervarix; and also reviewed abstracts from international meetings. both vaccines are intended to protect against cervical cancer and high-grade cin caused by hpv 16 and hpv 18. only the quadrivalent vaccine is designed to prevent condylomata ... | 2009 | 19386141 |
| human papillomavirus type 16 (hpv-16) virus-like particle l1-specific cd8+ cytotoxic t lymphocytes (ctls) are equally effective as e7-specific cd8+ ctls in killing autologous hpv-16-positive tumor cells in cervical cancer patients: implications for l1 dendritic cell-based therapeutic vaccines. | papillomavirus-like particles (vlps) based on l1 capsid protein represent a promising prophylactic vaccine against human papillomavirus (hpv) infections. however, cell-mediated immune responses against this antigen are believed to be of limited therapeutic value in established hpv-infected cervical lesions and, for this reason, have not been intensively investigated in cervical cancer patients. in this study we analyzed and quantified by real-time pcr (rt-pcr) the rna expression levels of e6, e7 ... | 2009 | 19386711 |
| antibody responses to 26 skin human papillomavirus types in the netherlands, italy and australia. | solar uv radiation is the main risk factor for cutaneous squamous cell carcinoma (scc), but infections with skin human papillomavirus (hpv) types have also been linked to the development of scc. little is known about the natural history of these infections and whether the seroprevalence of skin hpv types is affected by ambient or individual levels of sun exposure. this study investigated this by analysing sera for antibodies to 26 skin hpv types from five phylogenetic genera obtained from 807 he ... | 2009 | 19386782 |
| assessing the role of education in women's knowledge and acceptance of adjunct high-risk human papillomavirus testing for cervical cancer screening. | to assess women's knowledge, concerns, and willingness for adjunct high-risk human papillomavirus (hr-hpv) testing before and after an educational intervention. | 2009 | 19387125 |
| preventing cervical cancer through human papillomavirus vaccination: perspective from focus groups. | it has been a little more than a year ago since the prophylactic vaccine against human papillomavirus (hpv) was released in malaysia. little is known about parental knowledge and acceptability of the vaccine. the objective of this study is to assess the mother's knowledge and attitudes toward hpv vaccination. the results are aimed to provide insights into the provision of appropriate educational and promotional program for effective immunization uptake. | 2009 | 19387128 |
| risk factors & screening modalities for oral cancer. | dentists are at the forefront for screening oral cancer. in addition to the well known carcinogenic potential of tobacco and alcohol, betel nut chewing and human papilloma virus are important risk factors in the development of oral cancer. to aid in screening and decreasing morbidity and mortality from oral cancer, a variety of techniques have been developed. these techniques show promise but they require additional investigations to determine their usefulness in oral cancer detection. dentists ... | 2008 | 19388239 |
| hpv 16 e2 protein induces apoptosis in human and murine hpv 16 transformed epithelial cells and has antitumoral effects in vivo. | our aims were to examine the ability of the human papillomaviruse (hpv) 16 e2 protein to induce apoptosis in a murine hpv-transformed cell line, and to evaluate its antitumor properties on hpv-associated tumors in vivo in immunocompetent mice. | 2009 | 19390235 |
| human papilloma virus dna detection, p53 and ki67 expression in penile verrucous and squamous cell carcinomas in the same patient. | | 2009 | 19390495 |
| fdg-pet/ct: new horizons in anal cancer. | anal cancer is an uncommon tumor with an incidence of about one case per 100,000 in most countries. its incidence seems to be increasing because of exposure to human immunodeficiency virus (hiv) and human papillomavirus (hpv). traditional pretreatment evaluations include physical examination and ct imaging of the pelvis. current treatment guidelines include fluorodeoxyglucose positron emission tomography integrated with computed tomography (fdg-pet/ct) as part of the standard pretreatment workup ... | 2009 | 19394179 |
| comparison of the papillocheck dna micro-array human papillomavirus detection assay with hybrid capture ii and pcr-enzyme immunoassay using the gp5/6+ primer set. | cervical screening detects precancerous cells and routine screening could be improved by testing for human papillomavirus (hpv), the virus that causes cervical cancer. hpv infection is common and the benefit of hpv testing would be identification of women who are hpv negative and at low risk of developing cancer. | 2009 | 19394266 |
| understanding the reasons why mothers do or do not have their adolescent daughters vaccinated against human papillomavirus. | the objective of this study was to compare the reasons why mothers do or do not have their adolescent daughters vaccinated against hpv. | 2009 | 19394865 |
| at what age should cervical screening stop? | | 2009 | 19395422 |
| human papillomavirus, abstinence, and the other risks. | | 2009 | 19400001 |
| rna (e6 and e7) assays versus dna (e6 and e7) assays for risk evaluation for women infected with human papillomavirus. | in the majority of cases, high-risk human papillomavirus (hr hpv) infections regress spontaneously, with only a small percentage progressing to high-grade lesions. current screening methods are based on dna detection. an alternative would be to monitor expression of the e6 and e7 viral oncogenes continuously expressed by malignant phenotypes. in the work reported in this paper, we compared the two methods for a group of women with high-risk hpv infections. cervical specimens from 400 women, prev ... | 2009 | 19403762 |
| human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications. | over the past 20 years, high-risk human papilloma-virus (hpv) infection has been established as a risk factor for developing head and neck squamous cell carcinoma, independent of tobacco and alcohol use. in particular, hpv is strongly associated with the development of oropharyngeal cancer and a small minority of oral cavity cancers. in this review, we summarize what is currently known about the biology of hpv, the mechanisms by which it effects malignant transformation, and the potential impact ... | 2009 | 19407148 |
| cervical cancer screening among college students in ghana: knowledge and health beliefs. | cervical cancer is the most incident cancer and the leading cause of cancer mortality in women in ghana. currently, little is known about ghanaian women's knowledge and beliefs about cervical cancer screening, yet this information is essential to the success of cervical cancer screening programs. therefore, the purpose of this study was to describe the knowledge and beliefs of female university college students in ghana. | 2009 | 19407569 |
| hla-g polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus. | human papillomavirus (hpv) infection is etiologically associated with low- (lsil) and high-grade squamous intraepithelial lesions (hsil) and with cervical cancer. the progression or regression of the lesions may depend, among other factors, on the host heritable immune response. because human leukocyte antigen (hla)-g molecules are involved in the modulation of innate and adaptive immune responses, and because no previous studies have evaluated hla-g polymorphism in patients with sil, we conduct ... | 2009 | 19407850 |
| enhanced papillomavirus-like particle production in insect cells. | human papillomavirus (hpv) l1 self-assembles into virus-like particles (vlps), which are the basis for the two commercially available prophylactic vaccines. for one of them (cervarix) hpv 16 and 18 vlps are being produced in insect cells using the baculovirus expression system. however, due to low yield, production of vlps remains challenging for certain other pv types. here we report that employment of a modified baculovirus-based (multibac) expression system (berger, i., fitzgerald, d. j., and ... | 2009 | 19409593 |
| development and evaluation of a pcr and mass spectroscopy (pcr-ms)-based method for quantitative, type-specific detection of human papillomavirus. | knowledge of the central role of high-risk human papillomavirus (hpv) in cervical carcinogenesis, coupled with an emerging need to monitor the efficacy of newly introduced hpv vaccines, warrant development and evaluation of type-specific, quantitative hpv detection methods. in the present study, a prototype pcr and mass spectroscopy (pcr-ms)-based method to detect and quantitate 13 high-risk hpv types is compared to the hybrid capture 2 high-risk hpv dna test (hc2; digene corp., gaithersburg, md ... | 2009 | 19410602 |
| conjunctival papilloma. | | 2009 | 19410961 |
| role of e6/e7 onco-proteins of high-risk human papillomaviruses in human colorectal carcinogenesis. | | 2009 | 19411835 |
| entire genome characterization of human papillomavirus type 16 from infected thai women with different cytological findings. | global prevalence of human papillomavirus type 16 (hpv16) exceeds that of other types. this project has been aimed at attaining basic molecular knowledge of hpv16 by sequencing the whole genome of hpv16 isolated from thai women at various clinical stages of disease progression. our group analyzed seven samples of hpv16 in infected women ranging from normal to cervical cancer and discovered two critical non-synonymous changes within the coding region converting the e2-219p prototype to e2-219t in ... | 2009 | 19412733 |
| the genomics of oral cancer and wound healing. | oral cancer is the most common malignancy in india, where it is epidemiologically linked to the chewing of betel quid and other carcinogens. but various point mutations were detectable in the p53 and p15 genes. hence, this review was conducted with the aim to find out genetic risks as well as markers for oral cancers and wound healing. tobacco-related cancers are associated with polymorphisms of the cyp1a1 and gstm1 genes in terms of genotype frequencies and cigarette smoking dose. expression of ... | 2009 | 19414966 |
| epidemiology of cutaneous human papillomavirus infections. | | 2009 | 19415200 |
| statement on human papillomavirus dna test utilization. | | 2009 | 19415756 |
| current concepts in cervical pathology. | the correct diagnosis and reporting of cervical in situ and invasive carcinoma are essential for the appropriate clinical management of patients with human papillomavirus-associated disease. | 2009 | 19415947 |
| lack of detection of human papillomavirus infection by hybridization test in prostatic biopsies. | to explore the possibility of finding human papillomavirus (hpv) infection in the prostate tissue of a cohort of saudi men presenting with benign prostatic hyperplasia (bph) or prostate cancer. | 2009 | 19417961 |
| correlation of hpv-16/18 infection of human papillomavirus with lung squamous cell carcinomas in western china. | prevalent inconsistency of human papillomavirus (hpv) infection in lung cancer was found among recent studies from different countries with racial and geographic variations. even in chinese populations, the prevalent discrepancy of hpv infection in lung cancer patients was also found with the geographic variations and tumor types. to study the difference of hpv-16/18 infection in lung squamous cell carcinomas and non-cancer controls, we conducted this study to verify whether there was a similar ... | 2009 | 19424646 |
| the anti-apoptotic role for p53 following exposure to ultraviolet light does not involve ddb2. | the p53 tumour suppressor is a transcription factor that can either activate or repress the expression of specific genes in response to cellular stresses such as exposure to ultraviolet light. the p53 protein can exert both pro- and anti-apoptotic effects depending on cellular context. in primary human fibroblasts, p53 protects cells from uv-induced apoptosis at moderate doses but this is greatly affected by the nucleotide excision repair (ner) capacity of the cells. the damage-specific dna bind ... | 2009 | 19428372 |
| human papillomavirus vaccine decision-making in da nang, vietnam: perceived spousal and adolescent-parent concordance. | this descriptive study examined parents' perceptions of the role of mothers, fathers, and daughters in the decision to have their daughter receive the human papillomavirus (hpv) vaccine; perceived concordance between spouses and between parents and daughters; and the relationships between vaccine decision-making and (1) who takes the daughter to the doctor, and (2) the daughter's age. health care workers (n=139) with a daughter 9-21 years old completed a self-administered questionnaire including ... | 2009 | 19428852 |
| comparison of three management strategies for patients with atypical squamous cells of undetermined significance, after six months delay: a three-year experience in an iranian university hospital. | a pap test result of atypical squamous cells of undetermined significance (ascus) presents a clinical challenge. only 5-10% of women with ascus harbour serious cervical disease. | 2009 | 19432613 |
| human papillomavirus infections among japanese women: age-related prevalence and type-specific risk for cervical cancer. | to obtain baseline data for human papillomavirus (hpv) screening and vaccination in japan, we analyzed hpv dna data from 2282 japanese women (1517 normal cytology, 318 cervical intraepithelial neoplasia [cin] grade 1, 307 cin2-3, and 140 invasive cervical cancer [icc]) that visited the university of tsukuba hospital or ibaraki seinan medical center hospital for screening or treatment of cervical diseases between 1999 and 2007. an l1-based pcr method was used for individual hpv genotyping. the mo ... | 2009 | 19432906 |
| the evolving definition of carcinogenic human papillomavirus. | thirteen human papillomavirus (hpv) genotypes have been judged to be carcinogenic or probably carcinogenic, and the cause of virtually all cervical cancer worldwide. other hpv genotypes could possibly be involved. although the inclusion of possibly carcinogenic hpv genotypes may hurt test specificity, it may indirectly increase the reassurance following a negative hpv test (i.e. the negative predictive value of an hpv test for cervical precancer and cancer). the future of cervical cancer screeni ... | 2009 | 19432962 |
| human papillomavirus infection and cervical cytology in hiv-infected and hiv-uninfected rwandan women. | data on human papillomavirus (hpv) prevalence are essential for developing cost-effective cervical cancer prevention programs. | 2009 | 19435429 |
| a 7.5-year prospective study of longer than 18 months type-specific human papillomavirus persistence in a routine cytology-based cervical screening population of about 31,000 women in west germany. | the objective of this study was to analyse the prevalence, infection pattern, duration and outcome of long-term, type-specific, persistent human papillomavirus (hpv) infections in a routine cytology-based cervical screening population of west german women followed up for 7.5 years. from a screening population of 31,000 women, a strictly selected cohort of 100 patients with > or =18-month persistent, type-specific hpv infection were prospectively followed up for a mean of 35.52 months (+/-13.0). ... | 2009 | 19436214 |
| human papillomavirus vaccines: why the time is right to implement immunization and surveillance programs in canada. | | 2008 | 19436510 |
| [hpv caused pathological changes in genital system of mice]. | the recombined adenovirus dna was transfected into 293 cells for packing and amplification of replication-deficient ad-cmv-e6/e7, ad-k14 -e6/e7 virus was purified by cscl density gradient centrifugation , recombined adenovirus ad-cmv-e6/e7, ad-k14 -e6/e7 were used as experimental group, while pad-cmv and padtrack-k14 were used as control group. four of them were injected through one main vein of nude mice tail respectively. these mice were then treated with 0.05 mg 17beta-estradiol over 12 weeks ... | 2009 | 19437884 |
| prophylactic and therapeutic human papillomavirus vaccine: a breakthrough for women health. | human papilloma virus (hpv) associated cervical cancer is amongst the ten most common cancers in women in the developing world. new vaccines markedly reduce the economic burden of diseases on a country's health system. two types of hpv vaccines are available; prophylactic and therapeutic. prophylactic vaccines target (late protein) l1 and to a lesser extent l2, which stimulate neutralizing antibody response and are recommended to individuals prior to infection. therapeutic vaccines are recommend ... | 2009 | 19438137 |
| safety and preliminary efficacy data of a novel casein kinase 2 (ck2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies. | cervical cancer is now considered the second leading cause of death among women worldwide, and its incidence has reached alarming levels, especially in developing countries. similarly, high grade squamous intraepithelial lesion (hsil), the precursor stage for cervical cancer, represents a growing health problem among younger women as the hsil management regimes that have been developed are not fully effective. from the etiological point of view, the presence of human papillomavirus (hpv) has bee ... | 2009 | 19439079 |
| evaluation of an array-based method for human papillomavirus detection and genotyping in comparison with conventional methods used in cervical cancer screening. | cervical cancer is the second-most prevalent cancer in young women around the world. infection with human papillomavirus (hpv), especially high-risk hpv types (hr-hpv), is necessary for the development of this cancer. hpv-dna detection is increasingly being used in cervical cancer screening programs, together with the papanicolau smear test. we evaluated the usefulness of introducing this new array-based hpv genotyping method (i.e., clinical arrays papillomavirus humano) in the cervical cancer s ... | 2009 | 19439534 |
| human papillomavirus and genital cancer. | human papillomavirus (hpv) is one of the most common sexually transmitted infections world-wide. low-risk hpv-types are associated with genital warts. persistent infection with high-risk hpv-types is associated with genital cancers. smoking and hiv infection have consistently been associated with longer duration of hpv infection and risk for genital cancer. there is an increasing incidence of anal cancers, and a close association with hpv infection has been demonstrated. receptive anal sex and h ... | 2009 | 19439875 |
| vaccines for human papillomavirus infection: a critical analysis. | this article takes a critical look at the pros and cons of human papillomavirus (hpv) vaccines. there is enough evidence to suggest that the prophylactic vaccines are efficacious in preventing various benign and malignant conditions (including cervical cancers) caused by hpv. even though the vaccine is costly, hypothetical analysis has shown that hpv vaccination will be cost effective in the long run. therapeutic hpv vaccines used to treat established disease are still undergoing evaluation in c ... | 2009 | 19439876 |
| human papillomavirus research: do we still need animal models? | | 2009 | 19441096 |
| distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. | human papillomavirus (hpv) gene expression is dramatically altered during cervical carcinogenesis. because dysregulated genes frequently show abnormal patterns of dna methylation, we hypothesized that comprehensive mapping of the hpv methylomes in cervical samples at different stages of progression would reveal patterns of clinical significance. to test this hypothesis, thirteen hpv16-positive samples were obtained from women undergoing routine cervical cancer screening. complete methylation dat ... | 2009 | 19443004 |
| human papillomavirus type and clinical manifestation in seven cases of large-cell neuroendocrine cervical carcinoma. | large-cell neuroendocrine carcinoma (lcnec) of the uterine cervix is a very rare malignancy. we aimed to investigate the role of human papillomavirus (hpv) on the survival of patients, and its correlation with clinical parameters of hpv status or survival outcomes. only seven cases of lcnec were retrospectively collected among 8018 (0.087%) invasive cervical carcinomas from the cancer registry systems at mackay memorial hospital and veterans general hospital over a period of 17 years. the median ... | 2009 | 19443298 |
| human papillomavirus infection as a prognostic factor in oropharyngeal squamous cell carcinomas treated in a prospective phase ii clinical trial. | the aim of this study was to determine the presence of high-risk hpv-16 in patients with hnscc, assess the impact of hpv status on treatment response and survival in this select cohort treated with combined modality therapy and to identify the differences in hif-1alpha and vegf expression in hpv-positive and -negative tumors. | 2009 | 19443352 |
| opsoclonus myoclonus after human papilloma virus vaccine in a pediatric patient. | | 2009 | 19447066 |
| sulfated k5 escherichia coli polysaccharide derivatives: a novel class of candidate antiviral microbicides. | antiviral microbicides, topical agents that prevent sexually transmitted infections, mainly work by blocking the interaction between viral proteins and cell surface components. in many instances, virus-cell interaction is mediated by cell surface heparan sulfate proteoglycans (hspgs). hspgs are exploited as attachment receptors by three sexually transmitted viruses: human immunodeficiency virus (hiv), herpes simplex virus (hsv) and human papilloma virus (hpv). since these viruses can either infe ... | 2009 | 19447134 |
| how many cin2+ lesions can be avoided through hpv 16/18 vaccination? | | 2009 | 19449218 |
| [clinical, epidemiological, and pathogenetic aspects of formation of persisting forms of high oncogenic risk papillomavirus infection in women]. | to reveal factors related with presence of human papillomavirus in women. | 2009 | 19459488 |
| marrying research, clinical practice and cervical screening in australian aboriginal women in western new south wales, australia. | research shows that australian aboriginal women experience a significantly higher rate of mortality from cervical cancer than non-aboriginal women. we now understand that infection with human papillomavirus (hpv) is a necessary pre-requisite for cervical cancer. this knowledge, together with the development of prophylactic vaccines against the hpv types most commonly associated with cervical cancer (16 and 18), made it vital to gain nationally representative hpv genotyping data for australian wo ... | 2009 | 19459723 |
| surveillance of human papilloma virus infection and cervical cancer in kidney transplant recipients: preliminary data. | development of cancer after transplantation has rapidly became one of the leading causes of death in kidney transplant recipients with functioning grafts. anogenital malignant neoplasms may occur with a 14-fold increased incidence, and human papilloma virus (hpv) infection has been recently identified as the leading cause of cervical carcinoma. we report the preliminary findings of a prospective study that evaluated the incidence of hpv infection and cervical carcinoma in a population of kidney ... | 2009 | 19460514 |
| human papillomavirus-58 and -73-associated digital squamous cell carcinoma in a patient with aggressive digital papillary adenocarcinoma. | aggressive digital papillary adenocarcinoma (adpa) is a rare tumor that is considered to arise from eccrine sweat glands of the skin. it occurs predominantly in men with a mean age in the sixth decade. it shows a strong tendency for local recurrence and has the potential to metastasize to distant sites. prompt diagnosis and regular follow-up are important to ensure the best possible outcome. we discuss a case of recurrent adpa associated with subsequent squamous cell carcinoma (scc) in different ... | 2009 | 19461243 |
| [clear cells in cutaneous squamous cell carcinoma]. | although few cases of squamous cell carcinoma (scc) with clear cells have been published, we believe that these cells are often present in scc. | 2009 | 19463234 |
| vaccination with human papillomavirus type 16-derived peptides using a tattoo device. | tattooing has been shown to be very efficient at inducing immunity by vaccination with dna vaccines. in this study, we examined the usability of tattooing for delivery of peptide vaccines. we compared tattooing with subcutaneous (s.c.) needle injection using peptides derived from human papillomavirus type 16 (hpv16) proteins. we observed that higher peptide-specific immune responses were elicited after vaccination with the simple peptides (e7(44-62) and e7(49-57)) and keyhole limpet hemocyanin-( ... | 2009 | 19464530 |
| immune thrombocytopenic purpura following human papillomavirus vaccination. | | 2009 | 19464550 |
| knowledge of human papillomavirus: differences by self-reported treatment for genital warts and sociodemographic characteristics. | the aim of this study was to evaluate knowledge about human papillomavirus (hpv) in individuals with genital warts compared with women from the general population without genital warts. human papillomavirus (hpv) knowledge among women reporting treatment for genital warts compared with hpv knowledge in women reporting no treatment was assessed using data from the population-based 2005 health information national trends survey (hints). three percent (n = 97) of women answered "yes" and 97% (n = 3 ... | 2009 | 19466646 |
| recent advances in molecular gynaecological pathology. | this review gives an overview of recent advances in our understanding of the molecular basis of gynaecological malignancy, including cervical, vulval, endometrial and ovarian tumours. these advances are beginning to influence clinical practice, perhaps most notably with the introduction of human papillomavirus vaccination for the prevention of anogenital neoplasia, but are likely to have broader clinical implications as further details emerge. | 2009 | 19469886 |
| expression of the p16 and ki-67 in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection. | the purposes of this study were to evaluate the expression of p16(ink4a) (referred as to p16) and ki-67 in cervical intraepithelial neoplasia (cin), and the correlation between high-risk human papillomavirus (hpv) infection and the above biomarkers. | 2008 | 19471565 |
| epidemiology, prevention and treatment of cervical cancer in the philippines. | cervical cancer remains to be one of the leading malignancies among filipino women. high-risk human papillomavirus (hpv) types, such as 16 and 18, are consistently identified in filipino women with cervical cancer. factors identified to increase the likelihood of hpv infection and subsequent development of cervical cancer include young age at first intercourse, low socioeconomic status, high parity, smoking, use of oral contraception and risky sexual behaviors. cancer screening programs presentl ... | 2009 | 19471671 |
| high-throughput two-step lna real time pcr assay for the quantitative detection and genotyping of hpv prognostic-risk groups. | human papillomavirus (hpv) infection is a necessary event in the development of cervical carcinoma. high risk (hr) hpv genotypes, however, may progress differentially from low grade lesions to malignancy. | 2009 | 19473874 |
| validation of the spf10 lipa human papillomavirus typing assay using formalin-fixed paraffin-embedded cervical biopsy samples. | lower levels of performance of human papillomavirus (hpv) typing assays in studies using formalin-fixed paraffin-embedded (ffpe) tissue compared to those using exfoliated cervical cells have been reported. the interpretation of current studies is limited by bias in inclusion criteria, sample matching, and methods of cell collection. we aimed to validate ffpe tissue for typing by the use of the spf(10) lipa assay, comparing cervical scrapings to punch and cone biopsy specimens. we examined 165 pa ... | 2009 | 19474270 |
| prevalence and type distribution of human papillomavirus in 5,000 british columbia women--implications for vaccination. | human papilloma virus (hpv) prevalence studies performed in different regions and population groups across canada would inform public health decisions regarding implementation of anti-hpv vaccines. | 2009 | 19475481 |
| distribution of human papillomavirus genotypes in women with cervical cancer in slovenia. | the purpose of the present study was to establish the distribution of human papillomavirus (hpv) genotypes in a representative population of women with cervical cancer in slovenia in order to contribute to the lacking data on hpv in cervical cancer and to assess the potential local benefit of future prophylactic hpv vaccination. | 2009 | 19477061 |
| epidemiology and genotype distribution of human papillomavirus (hpv) in women of sardinia (italy). | the human papillomavirus (hpv) infection is necessary for the development of cervical cancer. our study aims to evaluate the rate of hpv circulation in our population, to identify the prevalent genotypes and to establish correlation with cervical abnormalities. furthermore, the awareness of women about hpv issues was investigated. this study included 864 women attending the oncologic prevention service for their routine pap test screening or the health promotion mother-child service for counsell ... | 2009 | 19480954 |
| human papillomavirus genotypes and phylogenetic analysis of hpv-16 variants in hiv-1 infected subjects in italy. | a cross-sectional study was carried out to improve the state of evidence regarding the spectrum of hpv types and hpv-16 lcr variants circulating among men and women infected with hiv-1 in italy. this study, conducted in 518 hiv-positive subjects (346 males and 172 females), showed a high prevalence of hpv anal infections (88.7%) in men and of cervical infections (65.1%) in women. a wide spectrum of hpv genotypes has been observed, as both single and multiple infections. low-risk hpv types 6, 11 ... | 2009 | 19480955 |
| anal hpv genotypes and related displasic lesions in italian and foreign born high-risk males. | anal intraepithelial neoplasia and anal cancer are closely related to infection from high-risk human papilloma virus (hpv) genotypes. since hpvs involved in disease progression are reported to vary by geographical regions, this study focuses on hpv genotypes spectrum in 289 males attending a sexual transmitted diseases (std) unit according to their nationality. anal cytology, digene hybrid capture assay (hc2) and hpv genotyping were evaluated in 226 italian (it) and 63 foreign born (fb) subjects ... | 2009 | 19480957 |
| distribution of human papillomavirus genotypes in invasive cervical cancer in italy: a representative, single institution case series. | despite worldwide human papillomavirus (hpv) types distribution showed constant rates of hpv 16/18 in cervical cancers, regional variations have been consistently documented. very little data is available on hpv genotype prevalence among italian women with invasive cervical cancer. this study aims to determine the hpv type distribution in cervical specimens obtained from italian women diagnosed with invasive cervical cancer and referred to the european institute of oncology (ieo). two hundred-si ... | 2009 | 19480958 |
| radiation response in two hpv-infected head-and-neck cancer cell lines in comparison to a non-hpv-infected cell line and relationship to signaling through akt. | human papilloma virus (hpv)-associated cancers of the head and neck (h&n) are increasing in frequency and are often treated with radiation. there are conflicting data in the literature regarding the radiation response in the presence of hpv infection, with some data suggesting they may be more sensitive to radiation. there are few studies looking at in vitro effects of hpv and further sensitization by inhibitors of specific signaling pathways. we are in the process of starting a clinical trial i ... | 2009 | 19480971 |
| treatment with demethylating agent, 5-aza-2'-deoxycytidine enhances therapeutic hpv dna vaccine potency. | dna vaccines have emerged as a potential alternative to current strategies to control cancer for their safety, stability and ease of preparation. we have previously demonstrated that a dna vaccine encoding calreticulin (crt) linked to human papillomavirus type 16 (hpv-16) e7 antigen (crt/e7) can generate significant e7-specific immune responses and antitumor effects in vaccinated mice, thus enhancing dna vaccine potency. another strategy to improve dna vaccine potency is by enhancing the level o ... | 2009 | 19481843 |
| mothers' intention for their daughters and themselves to receive the human papillomavirus vaccine: a national study of nurses. | the aims of this study were to examine mothers' intention to vaccinate their daughters and themselves against human papillomavirus and to determine which demographic, behavioral, and attitudinal factors were associated with intention to vaccinate daughters. | 2009 | 19482752 |
| a standardized framework for accurate, high-throughput genotyping of recombinant and non-recombinant viral sequences. | human immunodeficiency virus type-1 (hiv-1), hepatitis b and c and other rapidly evolving viruses are characterized by extremely high levels of genetic diversity. to facilitate diagnosis and the development of prevention and treatment strategies that efficiently target the diversity of these viruses, and other pathogens such as human t-lymphotropic virus type-1 (htlv-1), human herpes virus type-8 (hhv8) and human papillomavirus (hpv), we developed a rapid high-throughput-genotyping system. the m ... | 2009 | 19483099 |
| glassy cell carcinoma predominantly commits to a squamous lineage and is strongly associated with high-risk type human papillomavirus infection. | summary: glassy cell carcinoma (gcc) has been believed to have originated from reserve or uncommitted cells as a poorly differentiated adenosquamous carcinoma. this study includes immunoprofiles of p63, cytokeratin 17 (ck17), and cd44 to clarify which lineage of gcc is committed to human papillomavirus (hpv) detection, and to verify whether or not hpv plays a role in gcc. nine uterine gccs showing overwhelmingly glassy features were evaluated by an hpv genotyping chip and by immunohistochemistry ... | 2009 | 19483622 |
| genomic profiling identifies common hpv-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck. | it is well known that a persistent infection with high-risk human papillomavirus (hrhpv) is causally involved in the development of squamous cell carcinomas of the uterine cervix (cxsccs) and a subset of sccs of the head and neck (hnsccs). the latter differ from hrhpv-negative hnsccs at the clinical and molecular level. | 2009 | 19486517 |
| parents' views on 3 shot-related visits: implications for use of adolescent vaccines like human papillomavirus vaccine. | multidose adolescent-targeted vaccines, for example the human papillomavirus (hpv) vaccine, require parents and adolescents to have repeated interactions with the physician's office. we sought to evaluate parental views on participating in frequent vaccine-related encounters and their preferences for how these encounters should ideally be implemented. | 2009 | 19487172 |
| human papillomavirus in early laryngeal carcinoma. | to examine the role of hpv status in the etiology, prognosis, and treatment of head and neck squamous cell carcinoma in early larynx malignancies. | 2009 | 19489068 |
| age-based programs for vaccination against hpv. | the risk of infection with human papillomavirus (hpv) increases with age. answering the question of which age groups are appropriate to target for catch-up vaccination with the newly licensed quadrivalent hpv vaccine (types 6/11/16/18) will be important for developing vaccine policy recommendations. | 2009 | 19490561 |