| panax notoginseng saponins promotes proliferation and osteogenic differentiation of rat bone marrow stromal cells. | panax notoginseng saponins (pns) is the main effective component of panax notoginseng, have various pharmacologic activities such as antioxidant, anti-inflammatory, and estrogen-like bioactivities, have been shown to be an effective agent on anti-osteoporosis. bone marrow stromal cells (bmscs) play a crucial homeostatic role in skeletal modeling and remodeling due to their capability to differentiate into osteooblasts. whether pns has effect on osteogenic differentiation of bmscs are unknown. th ... | 2010 | 21167926 |
| [effect of total saponins of panax notoginseng on urinary albumin in patients with chronic renal failure]. | to observe the curative effect of total saponins of panax notoginseng (pns) on chronic renal failure (crf). | 2010 | 21190603 |
| panax notoginseng saponins potentiate osteogenesis of bone marrow stromal cells by modulating gap junction intercellular communication activities. | the chinese medicinal herb, panax notoginseng, has long been used to treat bone fractures and panax notoginseng saponins (pns) could promote bone formation. we investigated the effects of pns on gap junction intercellular communication (gjic) and osteogenesis-associated genes in rat bone marrow stromal cells (bmscs). | 2010 | 21220939 |
| [optimization of pns/tgco components effect on experimental qi stagnation and blood stasis type of coronary heart disease with increase-decrease baseline geometric proportion design method]. | preliminary exploration of panax notoginseng saponins (pns) and total saponins from cornus officinalis (tgco) components treatment and characteristics of qi stagnation and blood stasis type of coronary heart disease. | 2010 | 21243775 |
| [physiologic characteristics of panax notoginseng seeds during after-ripening process]. | the studies were carried out on the physiologic characteristics of panax notoginseng seeds during the after--ripening process in order to understand the seed's biochemical and physiological changes and lay the foundation for the germplasm conversation and breeding research of p. notoginseng seeds. | 2010 | 21246811 |
| anti-proliferative effects of raw and steamed extracts of panax notoginseng and its ginsenoside constituents on human liver cancer cells. | | 2011 | 21255464 |
| saponin accumulation in the seedling root of panax notoginseng. | | 2011 | 21255468 |
| isolation of four high-purity dammarane saponins from extract of panax notoginseng by centrifugal partition chromatography coupled with evaporative light scattering detection in one operation. | centrifugal partition chromatography (cpc), as a continuous liquid-liquid partition chromatography with no solid support matrix, combined with evaporative light scattering detection (elsd) was employed for systematic separation and purification of weak-chromophoric saponins from a highly valued and important traditional chinese herbal medicine, panax notoginseng. | 2011 | 21259375 |
| the antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of panax notoginseng in animal models of depression. | total saponins extracted from the caudexes and leaves of panax notoginseng (sclpn) have been used in the clinic for improving mental function, treating insomnia, and alleviating anxiety. the present study evaluated the potential antidepressant activity of sclpn in rodent models of depression and the mechanism of action of sclpn. mice were received sclpn at doses of 10-1000 mg/kg daily for 1, 7, and 14 days and then were subjected to the forced swim test and locomotor activity test. the results s ... | 2011 | 21273053 |
| red notoginseng: higher ginsenoside content and stronger anticancer potential than asian and american ginseng. | a systematic comparison of the ginsenosides and anticancer activities was performed among white (air-dried) and red (steamed) roots of notoginseng (ng, panax notoginseng), asian ginseng (ag, p. ginseng), and american ginseng (amg, p. quinquefolius). chemical profiles of different ginseng species were characterized, through simultaneous quantification of nineteen major ginsenosides, by hplc-uv at 202 nm. the antiproliferative and pro-apoptotic effects on human colorectal cancer cells were determi ... | 2011 | 21344064 |
| chemical fingerprinting and quantitative analysis of a panax notoginseng preparation using hplc-uv and hplc-ms. | | 2011 | 21349173 |
| [in vitro balanced sustained-release of panax notoginseng saponins controlled with various matrix materials]. | to explore the influence of matrix materials in complicate ingredients on traditional chinese medicine and investigate the excipients selection model based on balanced release characteristics of multicomponents, the influence of hpmc (k4m, k15m, k100m) and carbomer (934p, 971p, 974p) was illustrated by testing in vitro release of ginsenoside-rg1, ginsenoside-rb1 and notoginsenoside-r1 in panax notoginseng saponins (model drug, pns). according to in vitro release results of pns matrix tablets in ... | 2010 | 21355219 |
| [effects of combination of salvia miltiorrhiza and panax notoginseng on the pharmacokinetics of their major bioactive components in beagle dog]. | after oral administration of salvia miltiorrhiza (danshen in chinese), panax notoginseng (sanqi in chinese) and danshen sanqi combination suspensions to beagle dogs, the plasma concentration-time profiles of danshensu, tanshinone ii(a), cryptotanshinone, notoginsenoside r1, ginsenoside rg1 and rb1 were analyzed by lc-ms/ms. pharmacokinetic parameters were calculated and analyzed with bapp 2.0 software. the results showed that the cmax and auc of danshensu, notoginsenoside r1, ginsenoside rg1 and ... | 2010 | 21361045 |
| panax notoginseng attenuates bleomycin-induced pulmonary fibrosis in mice. | panax notoginseng (pn) is a traditional chinese herb experimentally proven to have anti-inflammatory effects, and it is used clinically for the treatment of atherosclerosis, cerebral infarction, and cerebral ischemia. this study aimed to determine the anti-inflammatory effects of pn against bleomycin-induced pulmonary fibrosis in mice. first, in an in vitro study, culture media containing lipopolysaccharide (lps) was used to stimulate macrophage cells (raw 264.7 cell line). tnf-a and il-6 levels ... | 2011 | 21423633 |
| [effect of panax notoginseng saponins on autograft tendon healing in bone tunnel: interface histological characteristics]. | to investigate the effect of panax notoginseng saponins (pns) on tendon healing in bone tunnel. | 2011 | 21438325 |
| screening of traditional chinese medicinal plants for quorum-sensing inhibitors activity. | the misuse of antibiotics has contributed to widespread development of antimicrobial resistance among clinically significant bacterial species. alternative approaches other than those using antibiotics are needed in the fight against infectious diseases. quorum sensing (qs) is an intercellular signaling and gene regulatory mechanism, which is used by a number of opportunistic pathogenic bacteria in determining virulence gene expression. the study of qs may yield another strategy for disease cont ... | 2011 | 21439518 |
| [breeding strains of panax notoginseng by using est-ssr markers]. | to comparatively determine the genetic variation and differentiation of different breeding strains of panax notoginseng for providing the basic information for genetic breeding. | 2011 | 21506401 |
| in vitro studies of gynura divaricata (l.) dc extracts as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. | to evaluate traditionally used herb, gynura divaricata (l.) dc (bai bei san qi) as in vitro inhibitors of key enzymes involved in the pathogenesis of hyperglycemia and hypertension. we also determined the distribution of enzyme inhibitory activities in different aqueous and non-aqueous extracts. | 2011 | 21570455 |
| effects of panax notoginseng saponins on proliferation and apoptosis of vascular smooth muscle cells. | aim of the study: atherosclerosis is a common cardiovascular disease, and linked with the development of many cardiovascular complications, such as myocardial ischemia and stroke. although pathogenesis of atherosclerosis is not completely elucidated, increasing evidence has demonstrated that abnormal proliferation of vascular smooth muscle cells (vsmcs) plays an important role in formation of atherosclerosis. previous studies showed that saponins from panax notoginseng (pns) possess anti-atheros ... | 2011 | 21619919 |
| panax notoginseng saponins inhibit ischemia-induced apoptosis by activating pi3k/akt pathway in cardiomyocytes. | aim of this study: the panax notoginseng saponins (pns) have been clinically used for the treatment of cardiovascular diseases and stroke in china. evidences demonstrated that pns could protect cardiomyocytes from injury induced by ischemia, but the underlying molecular mechanisms of this protective effect are still unclear. this study was aimed to investigate the protective effect and potential molecular mechanisms of pns on apoptosis in h9c2 cells in vitro and rat myocardial ischemia injury mo ... | 2011 | 21619920 |
| notoginsenoside st-4 inhibits virus penetration of herpes simplex virus in vitro. | further study on steam-treated notoginseng, the roots of panax notoginseng (burk.) f.h. chen (araliaceae), which is a famous traditional chinese medicine that is used both in raw and treated forms for a long time, led to the isolation of a new dammarane-type saponin, namely notoginsenoside st-4. its structure was elucidated to be 3β,12β,20(s)-tri-hydroxydammar-24-ene-3-o-β-d-xylopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 2)-β-d-glu-copyranoside, based on the detailed analyses of the 1d and 2d nmr ... | 2011 | 21623512 |
| induction of differentiation by panaxydol in human hepatocarcinoma smmc-7721 cells via camp and map kinase dependent mechanism. | panaxydol (pnd) is one of the main non-peptidyl small molecules isolated from the lipophilic fractions of panax notoginseng. the present study was carried out to demonstrate the potential effects of panaxydol on the induction of differentiation of human liver carcinoma cell lines smmc-7721. cell viability was evaluated by mtt method and trypan blue exclusion assay respectively. the changes of morphology were detected by transmission electron microscope. inhibitors were applied to detect the sign ... | 2011 | 21628989 |
| [accumulation of soil arsenic by panax notoginseng and its associated health risk]. | panax notoginseng is a valued traditional chinese medical herb. in this study, the arsenic (as) contamination of soil in p. notoginseng plantation area in wenshan (yunnan, china) was investigated; the absorption and accumulation of soil as by the p. notoginseng was revealed; and the associated health risk was evaluated. the results revealed that the soil as concentrations ranged between 6.9-242.0 mg x kg(-1). arsenic concentrations in 48% of the total soil samples were > 40 mg x kg(-1). the as c ... | 2011 | 21634192 |
| pharmacokinetics study of bio-adhesive tablet of panax notoginseng saponins. | panax notoginseng saponin (pns) is the main active gradient of chinese traditional medicine panax notoginseng. although its prominent therapeutic efficacy has been demonstrated by various researchers, the broader application is restricted by the low bioavailability of pns. this article aims to discuss pns's plasma pharmacokinetics after oral administration of bio-adhesive tablet of pns to beagle dogs and improve its bioavailability in comparison with normal tablet. the bio-adhesive tablet was pr ... | 2011 | 21658246 |
| n-butanol extracts of panax notoginseng suppress lps-induced mmp-2 expression in periodontal ligament fibroblasts and inhibit osteoclastogenesis by suppressing mapk in lps-activated raw264.7 cells. | objective: periodontitis is a group of inflammatory diseases that affect connective tissue attachments and the supporting bone that surround the teeth. osteoclasts are responsible for skeletal modeling and remodeling but may also destroy bone in several bone diseases, including osteoporosis and periodontitis. this study examined the anti-inflammatory effects of panax notoginseng (pn) on periodontal ligament fibroblasts (pdlfs) and raw264.7 cells under lipopolysaccharide (lps) induced inflammator ... | 2011 | 21703595 |
| [effect of panax notoginseng saponins on app gene transcription in the brain tissue of samp8]. | to study the effect of panax notoginseng saponins (pns) on learning and memory ability and app gene transcription in the brain tissue in senescence accelerated mouse prone 8 (samp8). | 2011 | 21818973 |
| induction of apoptosis in human promyelocytic leukemia hl60 cells by panaxynol and panaxydol. | panaxynol and panaxydol are naturally occurring polyacetylenes, isolated from the lipophilic fractions of panax notoginseng, that exert anti-proliferative effects against malignant cells. however, to the best of our knowledge, no study concerning the inhibitory effects of the two polyacetylenes on cell growth of human promyelocytic leukemia cells has been reported. in this paper, we examined the antiproliferation and proapoptotic effects of panaxynol and panaxydol on hl60 cells and investigated ... | 2011 | 21716177 |
| development and characterization of microsatellite markers for panax notoginseng (araliaceae), a chinese traditional herb. | ôçópremise of the study: microsatellite primers were developed for a chinese traditional herb, panax notoginseng, to investigate its genetic diversity and cultivar breeding. ôçómethods and results: twelve polymorphic microsatellite loci were isolated from the microsatellite-enriched genomic library of panax notoginseng. the polymorphisms were assessed in two populations and an assemblage containing individuals from the entire distribution area. the number of alleles per locus ranged from 3 to 12 ... | 2011 | 21821584 |
| trilinolein inhibits proliferation of human non-small cell lung carcinoma a549 through the modulation of pi3k/akt pathway. | trilinolein has been identified as one of the active constituents isolated from panax notoginseng used widely in traditional chinese medicine. protective actions of panax notoginseng against cerebral ischemia, beneficial effects on the cardiovascular system, and hemostatic, antioxidant, hypolipidemic, hepatoprotective, renoprotective and estrogen-like activities have been illustrated. in the present study, the effects of trilinolein on the growth of non-small cell lung carcinoma a549 were invest ... | 2011 | 21721158 |
| 25-och3-ppd induces the apoptosis of activated t-hsc/cl-6 cells via c-flip-mediated nf-κb activation. | 25-och(3)-ppd is a dammarane-type triterpene sapogenin isolated from the roots, leaves and seeds of panax notoginseng, which has shown anti-tumor effects in several human cancer lines. in this study, we evaluated the effects of 25-och(3)-ppd on apoptosis of activated t-hsc/cl-6 cells induced by tumor necrosis factor-α (tnf-α). the inhibitory effects of eleven compounds isolated from panax ginseng and p. notoginseng were detected in activated t-hsc/cl-6 cells. 25-och(3)-ppd produced a significant ... | 2011 | 21924252 |
| Inhibition of TLR Ligand- and Interferon Gamma-Induced Murine Microglial Activation by Panax Notoginseng. | Among the many products which influence microglial activation and resulting neuroinflammation, herbal medicine has recently drawn much attention due to its immunomodulatory and neuroprotective activities. The purpose of the current study was to investigate the effects of an extract of Panax notoginseng (NotoG™) on TLR ligand- and IFN?-induced activation in N9 and EOC20 microglial cells lines. NotoG suppressed microglial activation as measured by reduced expression of accessory molecules (CD40 an ... | 2011 | 22183805 |
| Ginsenoside-Rd potentiates apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through the mitochondrial pathway. | Our previous studies showed that ginsenoside-Rd, a purified component from Panax notoginseng, inhibited cell proliferation and reversed basilar artery remodeling. The aim of this study was to investigate whether ginsenoside- Rd influences H(2)O(2)-induced apoptosis in basilar artery smooth muscle cells (BASMCs). The results showed that ginsenoside-Rd significantly potentiated H(2)O(2)-induced cell death and cell apoptosis. This resulted in a concentration-dependent reduction of the cell viabilit ... | 2011 | 22076303 |
| effects and mechanisms of total panax notoginseng saponins on proliferation of vascular smooth muscle cells with plasma pharmacology method. | total panax notoginseng saponin (tpns) is extracted from panax notoginseng. our previous studies suggested that tpns could inhibit intimal hyperplasia. this study discussed the impact of tpns on the proliferation of vascular smooth muscle cells (vsmcs) and revealed the associated mechanisms through cell cycle-related factors and extracellular regulated protein kinase (erk) signal transduction pathway. | 2012 | 22150681 |
| proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury. | ethnopharmacological relevance: salvia miltiorrhiza and panax notoginseng are popularly used traditional chinese medicine for cardiovascular disorders and they are often used in the form of combination. however, mechanisms of their cardioprotective effects were still not clear. in the present study, the protective effects of salvianolic acids (sa), notoginsengnosides (ng) and combination of sa and ng (csn) against rat cardiac ischemia-reperfusion injury were checked and the protein expression pr ... | 2011 | 21903157 |
| ginsenoside rb3 exerts antidepressant-like effects in several animal models. | total ginsenosides have been shown to have therapeutic actions as antidepressants. we report a major active ingredient of total ginsenosides, the ginsenoside rb3 (rb3), which may have antidepressant-like effects. using the forced swim test, tail suspension test, and learned helplessness procedure, we found that rb3 had significant anti-immobility effects in mice in the forced swim and tail suspension tests and reduced the number of escape failures in the learned helplessness procedure. in a rese ... | 2011 | 21948936 |
| best case series program supportive cases of cordyceps militaris- and panax notoginseng-based anticancer herbal formula. | objective. the major aim of this study was to present 2 cancer cases treated with anticancer herbal formula panax notoginseng and cordyceps militaris. | 2011 | 21994206 |
| [inhibition of glutathione-s-transferase by total saponins of panax notoginseng and its kinetics analysis in liver of mice]. | to study the inhibition of glutathione-s-transferase by total saponins of panax notoginseng and its kinetics analysis in liver of mice. | 2011 | 22121814 |
| effects of panax notoginseng saponins on the activities of cyp1a2, cyp2c9, cyp2d6 and cyp3a4 in rats in vivo. | the aim of this study was to assess the influence of the panax notoginseng saponins (pns) on the activities of the drug-metabolizing enzymes cytochrome p450 (cyp450) 1a2, 2 c9, 2d6 and 3a4 in rats. the activities of cyp1a2, 2 c9, 2d6 and 3a4 were measured using specific probe drugs. after pretreatment for 1 week with pns or physiological saline (control group), probe drugs caffeine (10 mg/kg; cyp1a2 activity), tolbutamide (15 mg/kg; cyp2c9 activity), metoprolol (20 mg/kg; cyp2d6 activity) and da ... | 2011 | 22162298 |
| panax notoginseng saponins promote osteogenic differentiation of bone marrow stromal cells through the erk and p38 mapk signaling pathways. | the chinese medicinal herb, panax notoginseng, has long been used to treat bone fractures and panax notoginseng saponins (pns) could promote bone formation. here, we investigated whether pns could promote osteogenesis of bone marrow stromal cells (bmscs) through modulating the mapk signaling pathways, which are implicated in bmsc osteogenesis. we found that pns markedly increased the mineralization of bmscs by alizarin red s assays and stimulate alkaline phosphatase activity of these cells. addi ... | 2011 | 21865745 |
| panax notoginseng saponins inhibit zymosan a induced atherosclerosis by suppressing integrin expression, fak activation and nf-κb translocation. | ethnopharmacological significance: panax notoginseng saponins (pns) are ingredients extracted from traditional chinese medicinal herb panax notoginseng. it has been demonstrated that pns have extensive effects on the cardiovascular system, including inhibition of platelet aggregation, increasing blood flow, improving left ventricular diastolic function in hypertensive patients and anti-inflammatory effect. | 2011 | 21924337 |
| [In vivo distribution and pharmacokinetics of multiple effective components contained in Panax notoginseng saponins after intratympanic administration]. | To investigate in vivo distribution and pharmacokinetics of ginsenoside Rb1 (Rb1), ginsenoside Rg1 (Rg1 ) and sanchinoside R1 (R1) after intratympanic administration (IT) or intravenous administration (IV) of Panax notoginseng saponions (PNS) solution, and provide a novel route for delivering traditional Chinese medicine (TCM) to the brain. | 2011 | 22032151 |
| [screening of plant pathogenic fungi by ginsenoside compound k production]. | to screen a new strain which can transform panaxadiol saponins into the rare ginsenoside compound k. | 2011 | 22007540 |
| development and characterization of microsatellite markers for panax notoginseng (araliaceae), a chinese traditional herb. | • premise of the study: microsatellite primers were developed for a chinese traditional herb, panax notoginseng, to investigate its genetic diversity and cultivar breeding. • methods and results: twelve polymorphic microsatellite loci were isolated from the microsatellite-enriched genomic library of p. notoginseng. the polymorphisms were assessed in two populations and an assemblage containing individuals from the whole distribution area. the number of alleles per locus ranged from three to 12, ... | 2011 | 21926312 |
| prediagnostic methods for the hemolysis of herbal medicine injection. | the xue-sai-tong injection, a traditional chinese medicine injection with total saponins extracted from sanchi ginseng, has been used for more than half a hundred years to treat coronary artery disease. the study is to establish a prediagnostic method for the hemolytic adverse effect of herbal medicine injection by taking xue-sai-tong injection as an example. | 2011 | 21963556 |
| arsenic accumulation and resistance mechanism in panax notoginseng, a traditional rare medicinal herb. | panax notoginseng, a traditional rare chinese medicinal herb, was recently found to bring health risk to consumers, mainly because soil in its major plantation area was contaminated by arsenic (as). we investigated the effect of soil as pollution on the growth and as uptake of pot-cultured p. notoginseng, and the associated mechanisms of as stressed response. results showed that, comparing with p. notoginseng growing in a low-as soil, the root, stem, and leaf biomasses of those growing in a high ... | 2011 | 22189375 |
| Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer. | OBJECTIVE: To investigate the anticancer effects of warming and relieving cold phlegm formula (, WRCP), a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil (5-FU) on human breast cancer in vivo. METHODS: Seventy-two Nu/Nu mice inoculated with MDA-MB-231 breast ... | 2011 | 22160948 |
| herbal remedies supply a novel prospect for the treatment of atherosclerosis: a review of current mechanism studies. | atherosclerosis (as) is a systemic cardiovascular disease with complicated pathogenesis involving oxidative stress, endothelial dysfunction and chronic inflammation. increasing lines of evidence have questioned the statins-dominated treatment for as, including their dangerous side-effects such as the breakdown of muscle when taken in larger doses. a multifaceted approach that addresses all major risk factors or pathological targets may provide an ideal treatment for as. studies of the herbal rem ... | 2011 | 21928391 |
| target separation of a new anti-tumor saponin and metabolic profiling of leaves of panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry. | a method coupling high-performance liquid chromatography (hplc) with quadrupole time-of-flight mass spectrometers (qtof-ms) using an eletrospray ionization (esi) source was firstly developed for detection, characterization and guiding target separation of variants of protopanaxdiol saponin from leaves of panax notoginseng. under the guidance of lc-qtof-ms, a new trace saponin was probed according to the precise elemental compositions of molecular ions and the fragmentation behavior, and then sep ... | 2012 | 22047761 |
| effects of panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells. | we aimed to investigate the effects of panax notoginseng saponins (pns) on proliferation, differentiation and self-renewal of rat hippocampal neural stem cells (nscs) in vitro. rat hippocampal nscs were isolated from post-natal day 1 (p1) rats and cultured in a serum-free medium. the neurospheres were identified by the expressions of nestin, class iii β-tublin (tuj-1) and glial fibrillary acid protein (gfap). the cells were given pns and subjected to oxygen glucose deprivation (ogd) as an in vit ... | 2011 | 21905288 |
| Effects of panax notoginseng saponins on homing of C-kit+ bone mesenchymal stem cells to the infarction heart in rats. | To investigate the effects of panax notoginseng saponins (PNS) on homing of C-kit+ bone mesenchymal stem cells (BMSCs) to the infarction heart. | 2011 | 21977864 |
| comparative study on saponin fractions from panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion. | abstract: | 2011 | 21995855 |
| [colonization of arbuscular mycorrhizal fungi and dark septate endophytes in panax notoginseng]. | arbuscular mycorrhizal fungi (amf) and dark septate endophytes (dse) colonizing panax notoginseng in three main producing areas in wenshan prefecture of yunan province were investigated. the fungal colonization of 144 roots samples including healthy and rot roots of p. notoginseng with different age were observed by means of acid fuchsin stain. the results showed that p. notoginseng was the typical arbuscular mycorrhizal plant. although there was no significant difference in amf and dse coloniza ... | 2011 | 22121792 |
| transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside rg1 on capsaicin-induced interleukin-8 and prostaglandin e(2) production in hacat cells. | objectives ginsenoside rg1 (grg1), one of the major active constituents of panax notoginseng, has shown anti-inflammatory and antinocioceptic activity, but its role in keratinocytes needs further study. we have examined the inhibitory effect of grg1 on transient receptor potential vanilloid-1 (trpv1) activation in keratinocyte hacat cells and explored its involved mechanism. methods hek 293t cells over-expressing exogenous trpv1 were constructed and named hek 293t-trpv1 cells. the effects of g ... | 2012 | 22221101 |
| [effects of extracts from panax ginseng, panax notoginseng and ligusticum chuanxiong on expression of β-galactosidase and signal pathway p16-cyclin d/cdk-rb in vascular smooth muscle cells]. | to observe the pathological changes of vascular aging in spontaneously hypertensive rats (shrs), and the effects of extracts from panax ginseng, panax notoginseng (burk.) and ligusticum chuanxiong on vascular aging. | 2012 | 22237278 |
| [effect on elimination of pyrogen and effectual components of panax notoginseng saponins by ultrafiltration membranes of different cut-off molecular weight and different materials]. | to study the elimination effect of bacterial endotoxins and the transmittance of panax notoginseng saponins by ultrafiltration membranes of different cut-off molecular weight and different materials. | 2011 | 22500435 |
| analysis of the transcriptome of panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. | panax notoginseng (burk) f.h. chen is important medicinal plant of the araliacease family. triterpene saponins are the bioactive constituents in p. notoginseng. however, available genomic information regarding this plant is limited. moreover, details of triterpene saponin biosynthesis in the panax species are largely unknown. | 2011 | 22369100 |
| [status and prospective on nutritional physiology and fertilization of panax notoginseng]. | sanqi, panax notoginseng, is a famous traditional chinese herb, which has more than 400 years cultivation history in china. this paper has reviewed the studies on the suitable growing soil conditions for sanqi, mineral nutrition effects on sanqi, and the effects of nutrients uptake on the yield and quality of sanqi by applying fertilizer. thereafter, research needed to be put further efforts in the future has raised for discussion, and outlined the following topics for further research like the ... | 2011 | 22242417 |
| [study on the dynamic model with supercritical co2 fluid extracting the lipophilic components in panax notoginseng]. | to establish a dynamics model for extracting the lipophilic components in panax notoginseng with supercritical carbon dioxide (co2). | 2011 | 22233045 |
| hormesis-based anti-aging products: a case study of a novel cosmetic. | application of hormesis in aging research and interventions is becoming increasingly attractive and successful. the reason for this is the realization that mild stress-induced activation of one or more stress response (sr) pathways, and its consequent stimulation of repair mechanisms, is effective in reducing the age-related accumulation of molecular damage. for example, repeated heat stress-induced synthesis of heat shock proteins has been shown to have a variety of anti-aging effects on growth ... | 2012 | 23548988 |
| [inhibitory effect of pns on drug metabolism enzyme cyp3a in rat livers and its kinetic analysis]. | to study the inhibitory effect of total saponins of the root and rhizome of panax notoginseng (pns) on drug metabolism enzyme cyp3a in rat livers and its kinetic analysis. | 2012 | 23373227 |
| [systematic study on qams method for quality control of panax notoginseng]. | to establish a quantitative method of multi-components by single marker (qams) for determining ginsenoside rg1, rb1, rd, re and notoginsenoside r1 for the purpose of the quality control of panax notoginseng. | 2012 | 23373218 |