Publications

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utilization of rna in situ hybridization to understand the cellular localization of powassan virus rna at the tick-virus-host interface.skin is the interface between an attached, feeding tick and a host; consequently, it is the first line of defense against invading pathogenic microorganisms that are delivered to a vertebrate host together with tick saliva. central to the successful transmission of a tick-borne pathogen are complex interactions between the host immune response and early tick-mediated immunomodulation, all of which initially occur at the skin interface. the focus of this work was to demonstrate the use of rna in ...202032411615
powassan virus experimental infections in three wild mammal species.powassan virus (powv) is a tick-borne virus maintained in sylvatic cycles between mammalian wildlife hosts and ticks (primarily ixodes spp.). there are two currently recognized lineages, powv-lineage 1 (powv-l1) and deer tick virus (dtv; lineage 2), both of which can cause fatal neurologic disease in humans. increased numbers of human case reports in the northeastern and north central united states in recent years have fueled questions into powv epidemiology. we inoculated three candidate wildli ...202133534764
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