| recombination with two influenza b strains in the de-embryonated egg. | | 1954 | 13208487 |
| the antigenic variation of influenza b viruses; demonstration of an antigenic spectrum by use of titer ratios. | | 1953 | 13035132 |
| epidemic influenza b and c in navy recruits during winter of 1951-52. | | 1952 | 13037744 |
| [recent serological studies on the antigenic structure of influenza b strains]. | | 2006 | 13028068 |
| antigenic analysis of influenza b strains isolated in 1952. | | 1952 | 12997991 |
| hemophilus influenzae type b epiglottitis or acute supraglottic laryngitis in children. | | 1948 | 18866873 |
| influenza b; study of a localized outbreak preceding the 1945 epidemic. | | 1948 | 18861400 |
| investigations into acute infections of the respiratory tract; an epidemic of influenza b in the winter of 1946. | | 1948 | 18867833 |
| influenza and pneumonia; serologic studies during and after an outbreak of influenza b. | | 1948 | 18907888 |
| observations on an epidemic of influenza b occurring at the johns hopkins hospital in november-december, 1945. | | 1947 | 20268505 |
| the protective effect of vaccination against epidemic influenza b in an industrial plant. | | 1947 | 20285177 |
| the effect of vaccination on the incidence of influenza b. | | 1947 | 20279330 |
| infections of the nervous system occurring during an epidemic of influenza b. | | 1946 | 20277507 |
| an epidemic of influenza b in australia. | | 1946 | 20984927 |
| the protective effect of vaccination against epidemic influenza b. | | 1946 | 21027918 |
| protective effect of vaccination against induced influenza b. | | 1945 | 16695244 |
| an epidemic of influenza b occurring in a group of rheumatic children concurrent with an outbreak of streptococcal pharyngitis: clinical and epidemiological observations. | | 1941 | 16694834 |
| the tree shrew is a promising model for the study of influenza b virus infection. | influenza b virus is a main causative pathogen of annual influenza epidemics, however, research on influenza b virus in general lags behind that on influenza a viruses, one of the important reasons is studies on influenza b viruses in animal models are limited. here we investigated the tree shrew as a potential model for influenza b virus studies. | 2019 | 31174549 |
| divergent influenza-like viruses of amphibians and fish support an ancient evolutionary association. | influenza viruses (family orthomyxoviridae) infect a variety of vertebrates, including birds, humans, and other mammals. recent metatranscriptomic studies have uncovered divergent influenza viruses in amphibians, fish and jawless vertebrates, suggesting that these viruses may be widely distributed. we sought to identify additional vertebrate influenza-like viruses through the analysis of publicly available rna sequencing data. accordingly, by data mining, we identified the complete coding segmen ... | 2020 | 32962015 |
| antiviral properties of extracts of streptomyces sp. smu 03 isolated from the feces of elephas maximus. | actinobacteria are historically and continued to be an important source for drug discovery. the annual epidemics and periodic pandemics of humans induced by influenza a virus (iav) prompted us to develop new effective antiviral drugs with different modes of action. an actinobacterium of streptomyces sp. smu 03 was identified from the feces of elephas maximus in yunnan province, china. by employing an h5n1 pseudo-typed virus drug screening system, the anti-iav effect of the dichloromethane extrac ... | 2020 | 32330578 |
| mucosal immunity against neuraminidase prevents influenza b virus transmission in guinea pigs. | despite efforts to control influenza virus infection and transmission, influenza viruses still cause significant morbidity and mortality in the global human population each year. most of the current vaccines target the immunodominant hemagglutinin surface glycoprotein of the virus. however, reduced severity of disease and viral shedding have also been linked to antibodies targeting the second viral surface glycoprotein, the neuraminidase. importantly, antineuraminidase immunity was shown to be r ... | 2019 | 31113896 |
| cross-protective efficacy of monovalent live influenza b vaccines against genetically different lineages of b/victoria and b/yamagata in ferrets. | currently, two genetic lineages of influenza b virus, b/victoria and b/yamagata, are cocirculating in humans in various countries. this situation has raised a question regarding the possibility of cross-protection between b components of live attenuated influenza vaccine (laiv) belonging to different lineages. this study aimed to assess in naïve ferrets the potential protective activity of monovalent b-laivs against challenge with homologous and heterologous wild-type (wt) influenza b viruses. | 2018 | 30246028 |
| anti-influenza a viral butenolide from streptomyces sp. smu03 inhabiting the intestine of elephas maximus. | actinobacteria are a phylum of bacteria known for their potential in producing structurally diversified natural products that are always associated with a broad range of biological activities. in this paper, using an h5n1 pseudo-typed virus drug screening system combined with a bioassay guided purification approach, an antiviral butanolide (1) was identified from the culture broth of streptomyces sp. smu03, a bacterium isolated from the feces of elephas maximus in yunnan province, china. this co ... | 2018 | 29976861 |
| safety and immunogenicity of a novel quadrivalent subunit influenza vaccine in animal models. | background: compared with trivalent influenza vaccines, quadrivalent influenza vaccines are expected to provide wider protection against influenza b virus infections. we developed a novel quadrivalent subunit influenza vaccine which was distinct from the influenza vaccines available on the market in production process. in this research, we evaluated the safety and immunogenicity of the quadrivalent subunit influenza vaccine in animal models.methods: in toxicity assessment, 40 sd rats were random ... | 2020 | 32186950 |
| [swine-spread severe influenza-associated pneumonia: a case report and literature review]. | we report and analyze the clinical data of the first case of severe pneumonia caused by influenza b virus from swine. the patient, a 62 year-old male domestic pig breeder, was admitted to hospital because of fever and muscle pain for 5 days, and anhelation for 3 days. one week before the onset of disease, the patient kept close contact with pigs. ct scan of the chest showed diffuse infiltration in both lungs. influenza b virus antigen detection (colloidal gold method) was repeatedly positive. th ... | 2018 | 30643075 |
| cross-reactive and lineage-specific single domain antibodies against influenza b hemagglutinin. | influenza b virus (ibv) circulates in the human population and causes considerable disease burden worldwide, each year. current ibv vaccines can struggle to mount an effective cross-reactive immune response, as strains become mismatched, due to constant antigenic changes. additional strategies which use monoclonal antibodies, with broad reactivity, are of considerable interest, both, as diagnostics and as immunotherapeutics. alternatives to conventional monoclonal antibodies, such as single doma ... | 2019 | 31544820 |
| selective usage of anp32 proteins by influenza b virus polymerase: implications in determination of host range. | the influenza b virus (ibv) causes seasonal influenza and has accounted for an increasing proportion of influenza outbreaks. ibv mainly causes human infections and has not been found to spread in poultry. the replication mechanism and the determinants of interspecies transmission of ibv are largely unknown. in this study, we found that the host anp32 proteins are required for the function of the ibv polymerase. human anp32a/b strongly supports ibv replication, while anp32e has a limited role. un ... | 2020 | 33045004 |
| quadrivalent cell culture influenza virus vaccine. comparison to egg-derived vaccine. | influenza virus infections pose a serious public health problem and vaccination is the most effective public health intervention against them. the current manufacture of influenza vaccines in embryonated chicken eggs entails significant limitations. these limitations have been overcome by producing vaccines in cell culture, which allow a faster and more flexible response to potential pandemic threats. given the impact of influenza b virus on disease burden, the availability of quadrivalent vacci ... | 2020 | 32255723 |
| passaging of an influenza a(h1n1)pdm09 virus in a difluoro sialic acid inhibitor selects for a novel, but unfit i106m neuraminidase mutant. | an influenza a(h1n1)pdm09 and an influenza b virus were passaged in 3-fluoro(eq)-4-guanidino difluoro sialic acid (3feq4gu dfsa), an inhibitor of the influenza neuraminidase (na) to determine whether resistant variants could be selected. 3feq4gu dfsa is a mechanism-based inhibitor, forming a covalent link to y406 in the na active site. given its similarity to the natural substrate, sialic acid, we predicted resistant variants would be difficult to select. yields of both viruses decreased with pa ... | 2019 | 31233807 |
| pathogenicity and transmissibility assessment of two strains of human influenza virus isolated in china in 2018. | influenza season occurs every year in china, but its presentation was unusual in the period from december 2017 to early 2018. during this period, influenza activity was increasing across the country and was much greater than during the same period in previous years, with great harm to people's health. | 2021 | 33472481 |