| optical detection and grading of lung neoplasia by raman microspectroscopy. | the aim of this study was to investigate whether raman spectroscopy could be used to identify and potentially grade lung neoplasia in cell samples. normal human bronchial epithelial cells (hbepcs) were analyzed by raman spectroscopy and compared with (i) hbepcs expressing human papillomavirus (hpv) type 16 e7 or cdk4; (ii) the immortalized bronchial epithelial cell line bep2d and (iii) its asbestos-transformed derivative asbtb2a. overall, raman spectroscopy, in combination with a linear discrimi ... | 2009 | 18942712 |
| new approaches to cervical cancer screening in latin america and the caribbean. | cervical cancer remains an important public health problem in the latin america and caribbean region (lac), with an expected significant increase in disease burden in the next decades as a result of population ageing. prophylactic human papillomavirus (hpv) vaccine is currently unaffordable in lac countries. however, even if vaccination was implemented, an additional two decades will be required to observe its impact on hpv related disease and cancer. with some exceptions, cytology-based screeni ... | 2008 | 18945402 |
| recommendations for cervical cancer prevention in latin america and the caribbean. | cervical cancer control in the latin america and caribbean (lac) region has been, and remains, a priority and a major public health challenge. it also provides the opportunity for the advancement of research into novel cervical cancer preventative tools including the use of prophylactic human papillomavirus (hpv) vaccines, hpv-based screening options and low technology visual inspection methods. the challenges for prevention are compounded because cervical cancer cases continue to cluster in the ... | 2008 | 18945407 |
| burden and trends of type-specific human papillomavirus infections and related diseases in the asia pacific region. | we present the burden of human papillomavirus (hpv)-related cancers (cancers of the cervix, anogenital areas, and oral cavity and pharynx) in terms of incidence and mortality, for the countries of the asia pacific region. the region contains more than half of the world population, and manifests a wide geographic diversity in the prevalence of infection with hpv, and of incidence (and mortality) rates of cancer of the cervix. in general, rates of cancer of the cervix have declined since the 1960' ... | 2008 | 18945410 |
| human papillomavirus infection and cervical cancer prevention in japan and korea. | cervical cancer is a common cancer among women in japan and korea. implementation of national cervical cancer screening programs has led to a reduction in the incidence of cervical cancer in both countries. however, over the past decade, there has been a recent marked increase in cervical cancer incidence among young women in japan. human papillomavirus (hpv) is found in the majority of cervical cancers, and hpv-16 and 18 are the two most common types. the next most frequent hpv types in cervica ... | 2008 | 18945412 |
| human papillomavirus infection and cervical cancer prevention in india, bangladesh, sri lanka and nepal. | although one-third of the world cervical cancer burden is endured in india, bangladesh, nepal and sri lanka, there are important gaps in our knowledge of the distribution and determinants of the disease in addition to inadequate investments in screening, diagnosis and treatment in these countries. prevalence of human papillomavirus (hpv) infection among the general populations varies from 7-14% and the age-specific prevalence across age groups is constant with no clear peak in young women. this ... | 2008 | 18945413 |
| recommendations for cervical cancer prevention in asia pacific. | asia oceania includes countries from both the asia pacific region and australasia, which cover very diverse geographical areas and populations as well as bearing 52% of the cervical cancer burden in the world. human papillomavirus (hpv) genotype distribution in women with normal cytology varies between countries in this region, as well as with the distribution typically observed in worldwide estimates or in western countries. hpv-16 remains the predominant oncogenic type for high-grade cervical ... | 2008 | 18945418 |
| control of the papillomavirus early-to-late switch by differentially expressed srp20. | the viral early-to-late switch of papillomavirus infection is tightly linked to keratinocyte differentiation and is mediated in part by alternative mrna splicing. here, we report that srp20, a cellular splicing factor, controls the early-to-late switch via interactions with a/c-rich rna elements. an a/c-rich se4 element regulates the selection of a bovine papillomavirus type 1 (bpv-1) late-specific splice site, and binding of srp20 to se4 suppresses this selection. expression of late bpv-1 l1 or ... | 2009 | 18945760 |
| human papillomavirus type 16 e2 protein transcriptionally activates the promoter of a key cellular splicing factor, sf2/asf. | human papillomavirus (hpv) gene expression is regulated in concert with the epithelial differentiation program. in particular, expression of the virus capsid proteins l1 and l2 is tightly restricted to differentiated epithelial cells. for hpv16, the capsid proteins are encoded by 13 structurally different mrnas that are produced by extensive alternative splicing. previously, we demonstrated that upon epithelial differentiation, hpv16 infection upregulates hnrnp a1 and sf2/asf, both key factors i ... | 2009 | 18945764 |
| public knowledge and attitudes towards human papilloma virus (hpv) vaccination. | human papilloma virus (hpv) vaccine has undergone successful trials and has recently been approved for use for the primary prevention of cervical cancer. the aim of this study was to determine knowledge and attitudes towards hpv vaccination. | 2008 | 18947430 |
| kinase requirements in human cells: ii. genetic interaction screens identify kinase requirements following hpv16 e7 expression in cancer cells. | human papillomavirus (hpv) oncoproteins subvert cellular signaling pathways, including kinase pathways, during the carcinogenic process. to identify kinases targeted by the hpv16 e7 oncoprotein, shrna kinase screens were performed in rko colorectal carcinoma cell lines that differ only in their expression of hpv16 e7. our screens identified kinases that were essential for the survival of rko cells, but not essential for rko cells expressing hpv16 e7. these kinases include cdk6, erbb3, fyn, aak1, ... | 2008 | 18948598 |
| human papillomavirus in the placenta and umbilical cord blood. | to analyze human papillomavirus (hpv) dna in umbilical cord blood and in placenta, including its cellular localization. | 2008 | 18972230 |
| national ambulatory medical care survey: 2006 summary. | this report describes ambulatory care visits made to physician offices in the united states. statistics are presented on selected characteristics of the physician's practice, the patient, and the visit. | 2008 | 18972720 |
| prevalence, acquisition, and clearance of cervical human papillomavirus infection among women with normal cytology: hawaii human papillomavirus cohort study. | few natural history studies of cervical human papillomavirus (hpv) incidence and duration have been conducted among older women, especially from multiethnic populations. viral and nonviral determinants of hpv acquisition and clearance were examined among 972 sexually active women, ages 18 to 85 years, recruited from clinics on oahu, hawaii, and followed for a mean duration of 15 months (range, 2-56 months). interviews and cervical cell specimens for cytology and hpv dna detection by pcr, using t ... | 2008 | 18974124 |
| preparing for hpv vaccination in south africa: key challenges and opinions. | this article reports on qualitative research investigating key challenges and barriers towards human papillomavirus (hpv) vaccine introduction in the western cape province, south africa. a total of 50 in-depth interviews and 6 focus groups were conducted at policy, health service and community levels of enquiry. respondents expressed overall support for the hpv vaccine, underscored by difficulties associated with the current cervical screening programmes and the burgeoning hiv/aids epidemic in s ... | 2009 | 18977271 |
| prevalence of high-risk human papillomavirus among older women. | to estimate the prevalence, genotypes, and individual-level correlates of high-risk human papillomavirus (hpv) among women aged 57-85. | 2008 | 18978096 |
| examining the association between socioeconomic status and potential human papillomavirus-associated cancers. | this study examined the association between county-level measures of socioeconomic status (ses) and the incidence rate of human papillomavirus(hpv)-associated cancers, including cervical, vulvar, vaginal, anal, penile, and oral cavity and oropharyngeal cancers. | 2008 | 18980274 |
| human papillomavirus and molecular considerations for cancer risk. | human papillomaviruses (hpvs) are a major cause of cancer globally, including cervical cancer. the hpv 'early' proteins, e6 and e7, are the chief oncoproteins involved in cancer progression. these oncoproteins are more highly expressed in high-grade dysplasias and invasive cancer coincident with reduced viral dna replication and reduced production of infective progeny virions. the e6 and e7 oncoproteins interact with several cellular proteins-classically tp53 and rb1, respectively-leading to the ... | 2008 | 18980282 |
| predicting the effect of successful human papillomavirus vaccination on existing cervical cancer prevention programs in the united states. | the development of a prophylactic human papillomavirus (hpv) vaccine that potentially may eliminate a majority of cervical cancers is a landmark in cancer prevention. cervical screening, however, will continue to play an important role for the foreseeable future. maintaining screening at the same intensity and simply adding on the expense of vaccination would result in redundancy of prevention efforts at enormously increased costs without necessarily further reducing cervical cancer mortality. e ... | 2008 | 18980285 |
| descriptive epidemiology of vaginal cancer incidence and survival by race, ethnicity, and age in the united states. | vaginal cancer is a rare malignancy. it has many of the same risk factors as cervical cancer, including a strong association with persistent human papillomavirus infection. descriptive studies of the epidemiology of vaginal cancer are scarce in the literature. | 2008 | 18980291 |
| [item no 149: epithelial and melanoma skin tumors: tumors due to human papillomavirus]. | | 2008 | 18984204 |
| the rna stability regulator hur regulates l1 protein expression in vivo in differentiating cervical epithelial cells. | human papillomavirus (hpv) l1 and l2 capsid protein expression is restricted to the granular layer of infected, stratified epithelia and is regulated at least partly at post-transcriptional levels. for hpv16, a 79 nt late regulatory element (lre) is involved in this control. using w12 cells as a model for hpv16-infected differentiating cervical epithelial cells we show that hur, a key cellular protein that controls mrna stability, binds the lre most efficiently in nuclear and cytoplasmic extract ... | 2009 | 18986664 |
| aetiology of cancer in asia. | cancer has become the leading cause of death in many asian countries. there is an increasing trend in breast, prostate and colon cancers, which are considered as typical of economically developed countries. although breast and prostate cancer rates are still lower than in western countries, they are particularly rapidly increasing. in this paper, we review recently published literature to identify important etiologic factors affecting the cancer risk in asian populations. infectious agents such ... | 2008 | 18990005 |
| cervical cancer control research in vietnamese american communities. | census data show that the u.s. vietnamese population now exceeds 1,250,000. cervical cancer among vietnamese american women has been identified as an important health disparity. available data indicate the cervical cancer disparity may be due to low papanicolaou (pap) testing rates rather than variations in human papillomavirus infection rates and/or types. the cervical cancer incidence rates among vietnamese and non-latina white women in california during 2000 to 2002 were 14.0 and 7.3 per 100, ... | 2008 | 18990732 |
| infectious agents and colorectal cancer: a review of helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus. | based on the high volume of bacteria and viruses that the intestine is exposed to and the importance of infectious agents in some gastrointestinal and anogenital cancers, it is not surprising the many studies have evaluated the association between colorectal cancer and infectious agents. this review highlights investigations of four agents in relation to colorectal cancer. helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus have all been evaluated as possible etiologic a ... | 2008 | 18990738 |
| prevalence and age distribution of human papillomavirus infection in a population of inuit women in nunavik, quebec. | our aim was to study the prevalence and age distribution of human papillomavirus (hpv) infection among inuit women in nunavik, northern quebec, a population at high risk of cervical cancer. | 2008 | 18990756 |
| identification of the nuclear localization and export signals of high risk hpv16 e7 oncoprotein. | the e7 oncoprotein of high risk human papillomavirus type 16 (hpv16) binds and inactivates the retinoblastoma (rb) family of proteins. our previous studies suggested that hpv16 e7 enters the nucleus via a novel ran-dependent pathway independent of the nuclear import receptors (angeline, m., merle, e., and moroianu, j. (2003). the e7 oncoprotein of high-risk human papillomavirus type 16 enters the nucleus via a nonclassical ran-dependent pathway. virology 317(1), 13-23.). here, analysis of the lo ... | 2009 | 18996550 |
| human papillomavirus vaccine: are the concerns unfounded? | | 2008 | 18997145 |
| high-risk human papillomavirus dna load in a population-based cervical screening cohort in relation to the detection of high-grade cervical intraepithelial neoplasia and cervical cancer. | in a population-based cervical screening cohort, we determined the value of type-specific viral load assessment for the detection of high-grade cervical intraepithelial neoplasia and cervical cancer (>or=cin2). viral load was determined by type-specific real-time pcr in women with single hpv16,-18,-31 and -33 infections, as determined by gp5+/6+-pcr. study endpoints were the detection of cumulative >or=cin2 or>or=cin3 within 18 months of follow-up. high viral loads of hpv16,-31, and -33 were pre ... | 2009 | 19003961 |
| recurrent respiratory papillomatosis: update 2008. | recurrent respiratory papillomatosis (rrp) is the most common benign neoplasm of the larynx in children. over the past several years some exciting new therapeutic options as well as some relevant research into the disease process has emerged that may offer new insight and methods in managing this frustrating disease. | 2008 | 19005325 |
| human papillomavirus in hnscc: a european epidemiologic perspective. | the aim of this study was to assess incidence and survival of human papillomavirus-related and unrelated head and neck squamous cell carcinoma sites from 15 european population-based cancer registries. this analysis was performed on 29,265 adult (aged approximately 15 years) cancer patients diagnosed in the period from 1988 to 2002. the human papillomavirus-unrelated cancer sites had an age-standardized incidence higher than the human papillomavirus-related cancer cases (3.8 versus 2.5/100,000 y ... | 2008 | 19010264 |
| surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional hpv16-specific t-cell response. | to characterize hpv16 e6- and e7-specific t-cell immunity in patients with high-grade squamous intraepithelial lesions (hsil). | 2008 | 19010835 |
| mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of rpe biology. | development of immortalized mouse retinal pigmented epithelial cell (rpe) lines that retain many of their in vivo phenotypic characteristics, would aid in studies of ocular diseases including age related macular degeneration (amd). rpe cells were isolated from 18-month-old (estrogen receptor knockout) erkoalpha and erkobeta mice and their c57bl/6 wildtype littermates. rpe65 and cellular retinaldehyde binding protein (cralbp) expression, in vivo markers of rpe cells, were detected by real-time rt ... | 2009 | 19013153 |
| fanconi anemia deficiency stimulates hpv-associated hyperplastic growth in organotypic epithelial raft culture. | fanconi anemia (fa) is a recessive genome instability syndrome characterized by heightened cellular sensitivity to dna damage, aplastic anemia and cancer susceptibility. leukemias and squamous cell carcinomas (sccs) are the most predominant fa-associated cancers, with the latter exhibiting markedly early disease onset and aggressiveness. although studies of hematopoietic cells derived from fa patients have provided much insight into bone marrow deficiencies and leukemogenesis, molecular transfor ... | 2009 | 19015634 |
| scythe/bat3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. | papillomavirus binding factor (pbf) was first identified as a transcription factor regulating the promoter activity of human papillomavirus. we previously demonstrated that pbf is an osteosarcoma-associated antigen and 92% of osteosarcoma tissues express pbf in the nucleus. moreover, pbf-positive osteosarcoma has a significantly poorer prognosis than that with negative expression of pbf. in the present study, we assessed the biological role of pbf in cell survival. overexpression of pbf induced ... | 2009 | 19018758 |
| viral vaccines for dermatologic disease: some additional information regarding hpv and hsv. | | 2008 | 19022110 |
| alaska native parental attitudes on cervical cancer, hpv and the hpv vaccine. | to describe alaska native parents' knowledge of and attitudes towards cervical cancer, the human papillomavirus (hpv) and the hpv vaccine. | 2008 | 19024805 |
| oropharyngeal carcinoma in non-smokers and non-drinkers: a role for hpv. | incidence of oropharyngeal squamous cell carcinoma (oscc) increased 3% annually from 1973 to 2001. oscc's can be attributed to tobacco and alcohol, but 25% are unlinked to typical risks. case-control studies on hpv detection in non-smoking/non-drinking (ns/nd) oscc patients have not previously been performed. the primary objective of this study was to determine whether high-risk hpv infection was significantly associated with development of oral squamous malignancy in non-smokers/non-drinkers. a ... | 2009 | 19027350 |
| prevention of cervical cancer. | this article reviews the burden of cervical cancer in south africa and shows that it remains the most common cancer among south african women, particularly women with least access to cervical cancer screening. it explains the rationale behind the south african cervical cancer screening policy, which is to offer all asymptomatic women three free cervical smears in a lifetime, beginning at age 30, 10 years apart. further, it illustrates that cervical cancer screening offers unique opportunities fo ... | 2008 | 19027619 |
| human papillomavirus vaccination in the united kingdom: what about boys? | in september 2008 the uk department of health initiated a human papillomavirus (hpv) immunisation programme for girls aged 12-13 for prevention of cervical cancer, which is most often caused by two hpv types. an important question, yet to be addressed, is whether boys should also be vaccinated. men also get hpv and transmit it sexually, not just women. certain hpv types are associated with genital warts, which have significant morbidity, and with difficult to treat non-cervical malignancies, inc ... | 2008 | 19027627 |
| [human papilloma virus and cervical cancer]. | cervical cancer (cc) is the second most common cause of death from cancer among women worldwide and about 80% of the half of million new cases detected every year, occurs in less-developed countries. human papillomavirus is an obligate factor for the development of cc, since some hpvtype are detected in 100% of cc. hpv16 and hpv18 are the most common viral types, accounting for about 50% and 15% of cc, respectively. hpv infection is the most common sexual transmitted infection, with an estimated ... | 2006 | 19031679 |
| [construction of recombinant vaccinia virus expressing hpv18e7e6 fusion proteins and detection of its immunogenicity in mice]. | to construct one recombinant vaccinia virus expressing the hpv18 e6 and e7 fusion proteins as hpv18 therapeutic vaccine candidate, and test its immunogenicity. | 2008 | 19031699 |
| [laryngeal papillomatosis: etiology, diagnostics and therapy]. | papillomas are rare tumors that originate from the mucosa. they may appear in the nose, paranasal sinuses, oral cavity, larynx, trachea, or the skin. papillomas are mainly asymptomatic and are therefore mostly diagnosed coincidentally. in contrast, laryngeal papillomatosis may cause stridor, dyspnoea, and hoarseness. a viral cause of the disease seems likely, especially human papilloma virus. mechanical irritation is also a possible reason when the nose, oral cavity, or oropharynx is affected. a ... | 2008 | 19034400 |
| different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk hpv genotype. | human papillomavirus (hpv) dna sequences are associated with the large majority of invasive cervical carcinoma but the role of specific genotype(s) in the outcome of the disease is still debated. to determine the viral epidemiology in the french population of patients and the prognostic value of hpv genotypes in cervical cancer, we performed a retrospective study in 515 patients treated in our institution from 1985 to 2005. ninety-six percent of the cases were found associated with hpv dna where ... | 2009 | 19035459 |
| gene expression profile of cervical and skin tissues from human papillomavirus type 16 e6 transgenic mice. | although k14e6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. these findings suggest that e6 performs critical functions in normal adult cervix and skin, highlighting the need to define e6-controlled transcriptional programs in these tissues. | 2008 | 19036130 |
| analysis of human papillomavirus type 18 load and integration status from low-grade cervical lesion to invasive cervical cancer. | the clinical value of viral load and integration testing for human papillomavirus (hpv) remains unclear. data on hpv type 18 (hpv18) is limited. we examined the hpv18 viral load and integration status of 78 women with normal cervix or neoplasia. while the crude viral load appeared to increase with lesion severity, the association was not significant after normalization with sample cellularity. unlike reports for hpv16, the amino-terminal 1 region of hpv18 e2 was most frequently (71.0%) disrupted ... | 2009 | 19036939 |
| acog practice bulletin no. 99: management of abnormal cervical cytology and histology. | recent evidence has shown that the risk of malignant and premalignant cervical disease and human papillomavirus (hpv) infections varies significantly with age (1,2). furthermore, evidence now shows that treatment for cervical disease carries significant risk for future pregnancies (3-7). these factors have led to a re-evaluation of the guidelines for the management of premalignant cervical disease. the purpose of this document is to define strategies for diagnosis and management of abnormal cerv ... | 2008 | 19037054 |
| augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by co-expression of interleukin-12. | to enhance the efficacy of a therapeutic immunisation strategy against human papillomavirus-induced cervical cancer we evaluated the adjuvant effect of interleukin-12 (il12) expressed by a semliki forest virus vector (sfv) in mice. depending on the dose and schedule, sfv-il12 stimulated antigen-specific ctl responses elicited upon immunisation with recombinant sfv expressing hpv16-e6e7 (sfvee6,7). sfvee6,7-ctl and anti-tumour activity were enhanced by a low dose of sfv-il12 to the prime immunisa ... | 2009 | 19041356 |
| analytical evaluation of the papillocheck test, a new commercial dna chip for detection and genotyping of human papillomavirus. | recently, a commercially available hpv dna chip, the papillocheck test, developed by greiner bio-one, has become available for human papillomavirus (hpv) genotyping. the papillocheck test is a pcr-based test using a new consensus primer set targeting the e1 hpv gene. hpv oligoprobes immobilized on a dna chip allow for the identification of 24 hpv types from the amplified product. in the present study, the analytical performance of the papillocheck test is compared to the linear array hpv genotyp ... | 2009 | 19041893 |
| activation of the enhancer of zeste homologue 2 gene by the human papillomavirus e7 oncoprotein. | the malignant phenotype of human papillomavirus (hpv)-positive cancer cells is maintained by the activity of the viral e6 and e7 genes. here, we identified the polycomb group gene enhancer of zeste homologue 2 (ezh2) as a novel downstream target for the viral oncogenes in hpv-transformed cells. ezh2 expression was activated by hpv16 e7 at the transcriptional level via e7-mediated release of e2f from pocket proteins. rna interference analyses showed that continuous ezh2 expression is required for ... | 2008 | 19047178 |
| oral rinses may help detect human papillomavirus-positive head, neck cancers. | | 2008 | 19047664 |
| p16 ink4a immunostaining identifies occult cin lesions in hpv-positive women. | to evaluate whether p16 staining could help to recognize underestimated cervical intraepithelial neoplasia (cin) in women positive for high-risk human papillomavirus (hr-hpv) with negative biopsy. out of 1,259 women undergoing a histologic study and a simultaneous hr-hpv detection using the hybrid capture 2 test, we selected all patients testing positive for hr-hpv and having a negative biopsy (n=139), as well as all women testing negative for hr-hpv with a biopsy of either cin 1 (26 cases) or c ... | 2009 | 19047902 |
| anal intraepithelial neoplasia in a multisite study of hiv-infected and high-risk hiv-uninfected women. | to study anal intraepithelial neoplasia and its associations with anal and cervical human papillomavirus (hpv), cervical neoplasia, host immune status, and demographic and behavioral risk factors in women with and at risk for hiv infection. | 2009 | 19050387 |
| medicines management. | | 2008 | 19051531 |
| prevalence of human papillomavirus types in cervical and oral cancers in central india. | cervical cancer that is associated with high-risk human papillomaviruses (hpv) is the most common malignancy in indian women. therefore, the establishment of a prevention program is urgently required considering both vaccination and screening. however, relatively little is known about the prevalence of the different hpv types in cervical cancers in different regions of india, particularly central india. in this study, we have determined the hpv type distribution in 180 cervical cancers of women ... | 2009 | 19056450 |
| whim syndrome: congenital immune deficiency disease. | warts, hypogammaglobulinemia, infections, and myelokathexis (whim) syndrome is characterized by susceptibility to human papilloma virus infection-induced warts and carcinomas; neutropenia, b-cell lymphopenia and hypogammaglobulinema-related infections; and bone marrow myelokathexis (myeloid hyperplasia with apoptosis). the purpose of this report is to review new findings about whim. | 2009 | 19057201 |
| distribution and density of cd1a+ and cd83+ dendritic cells in hpv-associated laryngeal papillomas. | respiratory papillomatosis associated with human papilloma virus (hpv) infection is the most common benign laryngeal neoplasm. the age of patients at disease onset, hpv type, number of surgeries are well known prognostic factors of the disease course. the correlation between dendritic cell (dc) density in tumor tissue and clinical prognosis was established. | 2009 | 19062106 |
| self-collection of genital human papillomavirus specimens in heterosexual men. | we assessed the accuracy of self-collected human papillomavirus (hpv) specimens in men compared with clinician-collected specimens from men in british columbia and determined the prevalence of hpv subtypes at different male genital sites. | 2009 | 19066196 |
| malignancies in women with hiv infection. | women with hiv infection have an increased risk of developing certain malignancies. these malignancies are commonly human papillomavirus (hpv)-related, reflecting the high rate of coinfection with hpv in women with underlying hiv infection. these women also have a high incidence of premalignant hpv-related changes, such as high-grade squamous intraepithelial lesions as diagnosed on pap smears and cervical intraepithelial neoplasia on cervical biopsy. screening recommendations for hiv-infected wo ... | 2008 | 19072501 |
| cervical cancer screening with liquid cytology in women with developmental disabilities. | to evaluate the use of liquid cytology in pap smears in women with developmental disabilities (dd) for endocervical cell yield and abnormalities, via speculum examination or blind technique. | 2009 | 19072727 |
| systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy. | locally produced transforming growth factor-beta (tgf-beta) promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. this article explores the potential for increased efficacy when combining immunotherapies with tgf-beta suppression using the tgf-beta type i receptor kinase inhibitor sm16. adenovirus expressing ifn-beta (ad.ifn-beta) was injected intratumorally once in established s.c. ab12 (mesothelioma) and lkr (lung cancer) tumors or intratracheally in a kras o ... | 2008 | 19074893 |
| prevalence of human papillomavirus and chlamydia trachomatis infection among women attending cervical cancer screening in the republic of korea. | cervical cancer screening with the conventional papanicolaou test is recommended for the women aged 30 years and more in korea. cervical infection with human papillomavirus (hpv) is the most important cause of cervical cancer and chlamydia trachomatis (ct) is the most common bacterial sexually transmitted infection and may also be associated with risk of cervical cancer. a cross-sectional study of women attending the national cervical cancer screening program in busan and suwon was carried out. ... | 2009 | 19077566 |
| the common mechanisms of transformation by the small dna tumor viruses: the inactivation of tumor suppressor gene products: p53. | the small dna tumor viruses, polyoma virus, simian vacuolating virus 40, the papilloma viruses and the human adenoviruses, were first described during a period of intense virus discovery (1930-1960s) and shown to produce tumors in animals. in each of these cases the viral dna was shown to persist (commonly integrated into a host chromosome) and only a selected portion of this dna was expressed as m-rna and proteins in these cancers. the viral encoded tumor antigens were identified and shown to b ... | 2009 | 19081592 |
| the pro-angiogenic factors stimulated by human papillomavirus type 16 e6 and e7 protein in c33a and human fibroblasts. | to investigate the pro-angiogenic factors stimulated by human papillomavirus type 16 e6 and e7 protein in c33a and human fibroblasts. hpv-16 e6 and e7 genes were transfected into c33a and hfb to detect the profiling of angiogenesis-associated factors with the transignal angiogenesis antibody array. the mrna and protein levels of the cytokines were examined by traditional rt-pcr and western blotting in both cell lines before and after transfection of hpv-16 e6 and e7. hpv-16 e6 and e7 genes were ... | 2009 | 19082439 |
| identification of human papillomavirus in esophageal squamous papillomas. | to investigate the presence of human papillomavirus (hpv) in esophageal squamous papilloma (esp) and determine p16, p53 and ki67 expression in a mexican cohort. | 2008 | 19084918 |
| the role of male circumcision in the prevention of human papillomavirus and hiv infection. | | 2009 | 19086812 |
| human papillomavirus 6 seropositivity is associated with risk of head and neck squamous cell carcinoma, independent of tobacco and alcohol use. | the risk of head and neck squamous cell carcinoma (hnscc) associated with common human papillomavirus types has not been well defined. | 2009 | 19087986 |
| diminished ifn-gamma and il-10 and elevated foxp3 mrna expression in the cervix are associated with cin 2 or 3. | cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (hpv) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (cin). additionally, regulatory t (treg) cells are increasingly understood to be important modulators of cellular immunity. using quantitative rt-pcr, we measured, in cross-sectional design, the cervical mrna expression of ifn-gamma, il-10, and il-12, as ... | 2009 | 19089920 |
| implementing a school-based hpv vaccination programme. | the department of health launched a national human papillomavirus immunisation programme for girls aged 12-13 years in september 2008. | 2008 | 19090363 |
| [expression of skp2 in cervical squamous cell carcinoma and precancerous lesions and its correlation with hpv16/18 infection]. | to study the expression of skp2 in cervical squamous cell carcinoma (scc) and its precancerous lesions, and to investigate its relationship with human papillomavirus (hpv) infection. | 2008 | 19094580 |
| expression pattern and subcellular localization of human papillomavirus minor capsid protein l2. | the expression pattern of human papillomavirus (hpv) capsid antigen l2 is poorly described, and the significance of its localization with both promyelocytic leukemia protein (pml) and daxx in a subnuclear domain, nuclear domain 10 (nd-10), when ectopically expressed in tissue culture cells is controversial. to address whether nd-10 localization of l2 occurs in natural cervical lesions, we used a hpv16 and hpv18 l2-specific monoclonal antibody (rg-1), in addition to rabbit antiserum to hpv6 l2, t ... | 2009 | 19095951 |
| [etiology and pathogenesis of precancerous lesions and invasive cervical carcinoma]. | cervical cancer is the second most common gynecological malignancy in the world. human papilloma virus (hpv) infection is the leading ethiologic agent in the development of premalignant and malignant cervical diseases. hpv is a member of the papovaviridae family and until now over 100 types have been recognized there are two types of viral infection: latent and productive. virus induced oncogenesis is the result of interaction between virus oncoproteins e6 and e7 and tumor supresor host genes p5 ... | 2008 | 19097373 |
| access of black, hispanic, and nonprivately insured women to liquid-based cytology, human papillomavirus dna testing, and on-site colposcopy in the united states. | to determine whether patient race, ethnicity, or insurance status was associated with access to cervical cancer screening with liquid-based cytology (lbc) and with human papillomavirus (hpv) dna testing and with access to on-site colposcopy at the provider's principal practice site. | 2009 | 19098602 |
| immunogenicity and safety of human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine in healthy boys aged 10-18 years. | the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine (cervarix) has been shown to be well-tolerated and immunogenic in females aged 10 to 55 years, and up to 100% effective for the prevention of hpv-16/18 infection and associated precancerous cervical lesions in females aged 15 to 25 years. this study is the first to evaluate the immunogenicity and safety of the vaccine in males. | 2009 | 19101456 |
| [significance of human papillomavirus test in triage of patients with atypical squamous cell of undetermined significance]. | to investigate the significance of human papillomavirus test in triage of patients with atypical squamous cell of undetermined significance (ascus) diagnosed by cervical cytology. | 2008 | 19105350 |
| enhancement of immunotherapeutic effects of hpv16e7 on cervical cancer by fusion with ctla4 extracellular region. | cervical cancer is caused by infection by high-risk human papillomavirus (hpv), especially hpv16. limitations in current treatments of cervical cancers call for the development of new and improved immunotherapies. this study aims at investigating the efficacy of a novel vaccine consisting of modified hpv 16e7 fused with human cytotoxic t-lymphocyte antigen 4 (ctla4). the regions in hpv16 e7 gene associated with its transformation and ctl-enhanced response were modified; the resultant hpv16me7 wa ... | 2008 | 19107404 |
| determinants of incidence of primary fallopian tube carcinoma (pftc). | primary fallopian tube carcinoma (pftc) is a rare malignancy, but its incidence has been rising during the last decades and varies between 2.9/1,000,000 and 5.7/1,000,000. the epidemiology of pftc has been sparsely studied. in finland, the incidence rate has been rising during the last decades. the rise has been highest in the cities, in higher social classes, and in certain specific occupations. parity gives protection against this disease, as does a previous sterilization procedure. earlier th ... | 2009 | 19107444 |
| typing of human papillomavirus in women with cervical lesions: prevalence and distribution of different genotypes. | human papillomavirus (hpv) are distributed widely and persistent infection with high-risk (hr) hpv is recognized as a necessary cause of cervical cancer. the aim of this study was to evaluate the distribution of different hr-hpv genotypes in 199 women with cervical pre-invasive lesions undergoing conservative treatment. a linear array hpv genotyping test was used to identify individual hpv genotypes in cervical samples. it was observed that the most prevalent hpv genotypes were hpv 16 (52.6%), h ... | 2009 | 19107962 |
| genomic diversity of human papillomavirus (hpv) genotype 38. | human papillomavirus (hpv) genotype hpv 38 is a hpv genotype associated with skin cancer and is classified taxonomically in the beta-pv genus-species 2. at least six genomic variants of hpv 38, including prototype isolate and its subtype fa125, have been characterized so far. in order to investigate further the genomic diversity of hpv 38, a total of 39 hpv 38 positive samples obtained from hairs plucked from pubic, scrotal, perianal or eyebrow regions from 31 immunocompetent healthy male indivi ... | 2009 | 19107968 |
| tax1bp1 interacts with papillomavirus e2 and regulates e2-dependent transcription and stability. | the papillomavirus e2 proteins regulate viral replication, gene transcription, and genome maintenance by interacting with other viral and host proteins. from a yeast two-hybrid screen, we identified the cellular protein tax1bp1 as a novel binding partner of human papillomavirus type 18 (hpv18) e2. tax1bp1 also interacts with the hpv16 and bovine papillomavirus type 1 (bpv1) e2 proteins, with the c-terminal region of tax1bp1 interacting with the n-terminal transactivation domain of bpv1 e2. tax1b ... | 2009 | 19109394 |
| sequence variation of human papillomavirus type 16 and measurement of viral integration by quantitative pcr. | given that the integration of human papillomavirus type 16 (hpv16) into the host genome occurs preferentially with the disruption of the e2 gene, a ratio of e2 to e7 gene copies is often used as a marker for integration. it is largely undetermined, however, whether ratio estimates are affected by hpv intratypic variations. we assembled four plasmid constructs, each containing a dna fragment from an hpv16 european, asian-american, african-1, or african-2 variant. these constructs and nine cervica ... | 2009 | 19116350 |
| prevalence of human papillomavirus types 6, 11, 16 and 18 in young austrian women - baseline data of a phase iii vaccine trial. | cervical cancer is the second most common cancer among women worldwide. in the absence of changing risk or intervention, it is projected that in comparison with 2002 there will be a 40% increase in the number of new cases of cervical cancer by 2020. hpv types 16 and 18 cause 70% of cervical cancers worldwide, 50% of high-grade cervical intraepithelial neoplasias and 25% of low-grade neoplasias. hpv types 6 and 11 are the causative agent of > 90% of genital warts. the aim of this study was to ass ... | 2008 | 19116707 |
| antibody response for l1, e6, e7 hpv 16, and hpv 18 antigens in tunisian women with cervical cancer. | results obtained in the present work indicated that the luminex assay is more sensitive than elisa. the reactivity to the early antigens e6 and e7 was 37% versus 42% for hpv 16 and 21% versus 20% for hpv 18 among cervical cancer cases using elisa. however, these ratios were 44% and 61%, respectively, for e6 and e7 hpv 16 versus 28% and 21% for e6 and e7 hpv 18 when using the luminex technique. data also indicated that hpv 16 and hpv 18 showed distinct profiles for the different antigens tested. ... | 2009 | 19117204 |
| prevaccination distribution of human papillomavirus types in women attending at cervical cancer screening in belgium. | before the introduction of vaccination against human papillomaviruses (hpv) as a new strategy of combating cervical cancer, it is required to describe the baseline prevalence of hpv infection as well as the distribution of the different hpv types in the population and among women with cervical lesions. | 2009 | 19124515 |
| variables associated with human papillomavirus (hpv) vaccine acceptance by men. | to determine correlates of human papillomavirus (hpv) vaccine acceptance for men. | 2009 | 19124631 |
| detection of human papillomavirus dna in retinoblastoma samples: a preliminary study. | recent studies have shown the presence of human papillomavirus (hpv) genome in retinoblastoma (rb) tumor samples. there is no information on the hpv status in the rb tumors of indian patients. we studied the presence of hpv genome in rb tumor samples from patients with unilateral tumor. forty-four fresh rb tumor samples and 30 non-neoplastic donor retinas were analyzed for the presence of hpv 16 and 18 genome by nested and seminested polymerase chain reaction. tumor tissue sections were also use ... | 2009 | 19125079 |
| an hpv 16 l1-based chimeric human papilloma virus-like particles containing a string of epitopes produced in plants is able to elicit humoral and cytotoxic t-cell activity in mice. | even though two prophylactic vaccines against hpv are currently licensed, infections by the virus continue to be a major health problem mainly in developing countries. the cost of the vaccines limits wide-scale application in poor countries. a promising strategy for producing affordable and efficient vaccines involves the expression of recombinant immunogens in plants. several hpv genes have been expressed in plants, including l1, which can self-assemble into virus-like particles. a plant-based, ... | 2009 | 19126233 |
| human papillomavirus--lessons from history and challenges for the future. | human papillomavirus (hpv) is the most common sexually transmitted infection, and hpv-associated cervical cancer is a significant cause of morbidity and mortality worldwide. recent advances in molecular biology have facilitated testing for hpv infection. over the last decade, national and international cervical cancer screening programs have added hpv testing to their guidelines. the use of hpv prophylactic and therapeutic immunization may expand the need for systematic hpv testing to help defin ... | 2008 | 19126284 |
| epidemiological data of different human papillomavirus genotypes in cervical specimens of hiv-1-infected women without history of cervical pathology. | to study the epidemiology of different human papillomavirus (hpv) genotypes in cervical samples of hiv-1-infected women with normal papanicolau smears. | 2009 | 19131892 |
| single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous sccs. | cutaneous squamous cell carcinomas (csccs) are the second most frequent cancers in fair-skinned populations; yet, because of their genetic heterogeneity, the key molecular events in cscc tumorigenesis remain poorly defined. we have used single nucleotide polymorphism microarray analysis to examine genome-wide allelic imbalance in 60 csccs using paired non-tumor samples. the most frequent recurrent aberrations were loss of heterozygosity at 3p and 9p, observed in 39 (65%) and 45 (75%) tumors, res ... | 2009 | 19131950 |
| expression of human papilloma virus type 16 e5 protein in amelanotic melanoma cells regulates endo-cellular ph and restores tyrosinase activity. | melanin synthesis, the elective trait of melanocytes, is regulated by tyrosinase activity. in tyrosinase-positive amelanotic melanomas this rate limiting enzyme is inactive because of acidic endo-melanosomal ph. the e5 oncogene of the human papillomavirus type 16 is a small transmembrane protein with a weak transforming activity and a role during the early steps of viral infections. e5 has been shown to interact with 16 kda subunit c of the trans-membrane vacuolar atpase proton pump ultimately r ... | 2009 | 19133143 |
| palliative aspects of recurrent respiratory papillomatosis. | recurrent respiratory papillomatosis (rrp) is a chronic, frequently debilitating, and potentially life-threatening disease. therapy for rrp has evolved from simply inserting a tracheotomy to provide an airway and plucking out papillomata with cup forceps to provide some degree of voice to the present-day far more sophisticated approaches, along with preventative measures that may someday offer the potential dramatically to decrease disease prevalence. family dynamics and support and intentional ... | 2009 | 19134490 |
| enhancement of dendritic cell-based vaccine potency by anti-apoptotic sirnas targeting key pro-apoptotic proteins in cytotoxic cd8(+) t cell-mediated cell death. | dendritic cells (dcs) have become an important measure for the treatment of malignancies. current dc preparations, however, generate short-lived dcs because they are subject to cell death from various apoptotic pressures. antigen-specific cd8(+) cytotoxic t lymphocytes (ctls) is one of the main obstacles to limit the dc-mediated immune priming since ctls can recognize the target antigen expressing dcs as target cells and kill the dcs. ctls secret perforin and serine protease granzymes during ctl ... | 2009 | 19135479 |
| [epidermoid anal carcinoma]. | epidermoid carcinoma of the anus is a rare cancer, and conventionally affects elderly women. its incidence is on the increase, at a younger age of onset, particularly within the male homosexual population. main predisposing factors are sexually transmitted diseases and particularly human papillomavirus (hpv) infection, variety of sexual partners, smoking, homosexuality, history of uterine cervix cancer, and immunodepression. warning signs of anal cancer are often non-specific. therefore any atyp ... | 2008 | 19143150 |
| asymmetric gp5+/6+ pcr and hybridization with fluorescence polarization assay of 15 human papillomavirus genotypes in clinical samples. | the detection of a broad spectrum of hpv genotypes has not been used widely in cervical cancer screening due to technical difficulties and high costs. | 2009 | 19144564 |
| molecular hpv typing as a diagnostic tool to discriminate primary from metastatic squamous cell carcinoma of the lung. | in this study, typing of human papilloma virus (hpv) was performed in squamous cell carcinomas of the lung (n=26) as well as putative primaries of head and neck (n=21) and female genital tract (n=5) of the same patients, to test whether additional information to discriminate lung primaries from metastases can be gained by a direct comparison of the hpv status in both tumors. in 3 (14.2%) patients with head and neck as well as lung squamous cell carcinoma, an identical hpv subtype could be detect ... | 2009 | 19145203 |
| prevalence of human papillomavirus genotypes in women from a rural region of puebla, mexico. | to determine the prevalence of human papillomavirus (hpv) genotypes 6, 11, 16, 18, and 31 in mexican women living in rural areas of puebla, mexico and to evaluate risk factors associated with cervical neoplasm in this population. | 2009 | 19147384 |
| chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas. | cervical cancer develops from precancerous high-grade cervical intraepithelial neoplasia (cin) harboring a transforming infection with high-risk human papillomavirus, which is characterized by p16(ink4a) overexpression. once such a lesion has developed, progression toward an invasive squamous cell carcinoma (scc) may take one or more decades, underlining the heterogeneity of these lesions in terms of duration of existence and progression risk. we performed array-based comparative genomic hybridi ... | 2009 | 19147580 |
| anticancer effects on tacc3 by treatment of paclitaxel in hpv-18 positive cervical carcinoma cells. | previously, we used proteome analysis to identify transforming acidic coiled coil (tacc) 3 as a protein that is down-regulated upon paclitaxel treatment in cervical cancer cells. tacc3 mrna and protein levels decreased after paclitaxel treatment in a time- and dose-dependent manner, and the transactivation of tacc3 promoter was dramatically diminished by paclitaxel. importantly, paclitaxel treatment and knockdown of tacc3 by sirna led to a synergistic enhancement of significant g2/m phase arrest ... | 2009 | 19148534 |
| the catch up program for human papillomavirus vaccine. | | 2008 | 19149027 |