| screening for sexually transmitted disease in london-based male prostitutes. | to provide a screening service for sexually transmissible infections to male prostitutes working in the london area. | 1991 | 2032701 |
| haemophilus influenzae infection of urinary tract. | | 1991 | 2034160 |
| fine-needle aspiration in recurrent tonsillitis. | the incidence of tonsillitis that is unresponsive to penicillin therapy is leading to concern. this phenomenon has been linked to a change in the core tonsil bacteria, in particular beta-lactamase production. to date, the only way to identify the presence of these resistant microbes is at tonsillectomy. in this prospective study, we performed fine-needle tonsil aspiration in 34 patients (mean age, 7.6 years) before tonsillectomy. the bacteriologic nature of the aspirate was compared with that ob ... | 1991 | 2036188 |
| isolation and characterisation of haemophilus influenzae type b mutants defective in transferrin-binding and iron assimilation. | the quinone antibiotic streptonigrin was used to select mutants of haemophilus influenzae type b defective in human transferrin binding. compared with the parent wild-type strain (jkp1), mutant jkp5 was unable to bind transferrin whilst mutant jkp4 showed reduced binding. jkp5 appeared to lack an approximately 72 kda transferrin-binding protein. unlike jkp1, neither jkp4 nor jkp5 were able to acquire iron from human transferrin but their ability to use a variety of other iron and haem compounds ... | 1991 | 2037233 |
| comparison and analysis of the nucleotide sequences of pilin genes from haemophilus influenzae type b strains eagan and m43. | previous studies have demonstrated antigenic differences among the pili expressed by various strains of haemophilus influenzae type b (hib). in order to understand the molecular basis for these differences, the structural gene for pilin was cloned from hib strain eagan (p+) and the nucleotide sequence was compared to those of strains m43 (p+) and 770235 b0f+, which had been previously determined. the pilin gene of hib strain eagan (p+) had a 648-bp open reading frame that encoded a 20-amino-acid ... | 1991 | 2037360 |
| the relationship of tonsil bacterial concentration to surface and core cultures in chronic tonsillar disease in children. | fifty-five tonsils removed for chronic tonsillar disease (chronic tonsillitis and obstructive tonsillar hyperplasia) underwent surface swab and quantitative core cultures in order to identify the relationship between core bacterial concentration and the presence of aerobic bacteria on the tonsil surface. the accuracy of a single core culture was further established by quantitative cultures of 9 sections per tonsil in an additional 19 tonsils. the results indicate that many (61.5%) but not all ae ... | 1991 | 2037416 |
| reproducibility of disc susceptibility tests with haemophilus influenzae. | triplicate susceptibility tests were performed in each of three laboratories with 45 strains of haemophilus influenzae and a single lot of haemophilus test medium (htm) agar plates. using clarithromycin, erythromycin and chloramphenicol discs. zone sizes varied over ranges averaging only 4.3-5.8 mm. ampicillin zone sizes were more variable, especially when beta-lactamase-producing strains were being tested, but the latter strains were consistently categorized as being resistant. a 94% interpreti ... | 1991 | 2037535 |
| new aspects of antimicrobial resistance and the resulting therapeutic dilemmas. | emergence of resistance to antimicrobial agents among previously susceptible organisms continues to be an important obstacle to the successful treatment of bacterial infections. in hospitals, plasmid-mediated resistance to third-generation cephalosporins and monobactams has recently appeared in gram-negative bacilli, due primarily to mutations in tem- and shv-type enzymes. among nosocomial enterococci, vancomycin resistance, beta-lactamase production, and high-level resistance to all aminoglycos ... | 1991 | 2037783 |
| induction of suppurative arthritis in rabbits by haemophilus endotoxin, tumor necrosis factor-alpha, and interleukin-1 beta. | because haemophilus influenzae type b (hib) is the principal cause of suppurative arthritis in young children and its lipooligosaccharide (los) is thought to be the main virulence factor, hib endotoxin was evaluated for its ability to induce synovial inflammation in rabbits. also, the role of the cytokines tumor necrosis factor-alpha (tnf alpha) and interleukin-1 beta (il-1 beta) in mediating the synovial inflammatory process was studied. intraarticular inoculation of 2 pg to 20 ng of hib los pr ... | 1991 | 2037791 |
| relationship between intracellular survival in macrophages and virulence of haemophilus influenzae type b. | the phagocytosis of haemophilus influenzae type b (hib) by rat macrophages and the intracellular fate of ingested organisms was investigated using an acridine orange-crystal violet assay. there was a correlation between the ability of organisms to survive in macrophages in vitro and their ability to cause invasive disease. encapsulated hib survived and replicated within macrophages, whereas capsule-deficient mutants, although more susceptible to phagocytosis, were killed after ingestion. differe ... | 1991 | 2037802 |
| activity of temafloxacin against respiratory pathogens. | the activity of the quinolone temafloxacin against respiratory pathogens was compared with those of ciprofloxacin and ofloxacin. mics for 90% of strains tested indicated that temafloxacin was at least two- to fourfold more potent than the other two quinolones against staphylococcus aureus, streptococcus pneumoniae, and legionella pneumophila. temafloxacin had potency equal to that of ciprofloxacin and was twofold more active than ofloxacin against streptococcus pyogenes. moraxella catarrhalis, a ... | 1991 | 2039192 |
| activity of a new carbapenem antibiotic, meropenem, against haemophilus influenzae strains with beta-lactamase- and non-enzyme-mediated resistance to ampicillin. | meropenem was 8- to 32-fold more active (mic for 90% of strains = 0.125 micrograms/ml) than imipenem against a collection of haemophilus influenzae strains characterized as either susceptible to ampicillin or resistant to that agent by virtue of beta-lactamase or nonenzymatic mechanisms. mbcs and kinetic kill curve tests showed that meropenem (as well as imipenem, several cephalosporins, and amoxicillin-clavulanate) was bactericidal against all strains at or within four times the respective mics ... | 1991 | 2039214 |
| infantile meningitis in england and wales: a two year study. | a two year prospective study identified 1922 cases of meningitis in children under 1 year of age. a further 201 cases were identified from other sources. the annual incidence of meningitis during the first year of life was 1.6/1000; during the first 28 days of life it was 0.32/1000, and among postneonatal infants it was 1.22/1000. the male:female ratio was 1.4:1. the overall case fatality rate was 19.8% for neonates and 5.4% for postneonatal infants. two thirds of deaths identified in the study, ... | 1991 | 2039250 |
| septicaemia and adrenal haemorrhage in congenital asplenia. | five patients developed overwhelming infection as a result of congenital asplenia, which was previously unsuspected in all cases. each illness followed a fulminant course resulting in death within 24 hours. they illustrate the respective roles of haemophilus influenzae infection (n = 4) and adrenal haemorrhage (n = 4) in this condition. we suggest a management protocol for screening infants with abnormalities of the atria or viscera with splenic ultrasound and examination of a blood film for how ... | 1991 | 2039257 |
| the expression of small cell lung cancer related antigens in foetal lung and kidney. | the presence and distribution of antigens recognised by the antibodies submitted to the second international workshop on small cell lung cancer antigens has been mapped on human foetal lung and kidney using a streptavidin immunoperoxidase technique on frozen tissue sections. thirteen of the antibodies showed no staining at all on these tissues and five showed staining of all structures in all tissues of equal intensity. the staining patterns of the remaining antibodies could be divided into seve ... | 1991 | 2039712 |
| detection and characterization of human t-cell lymphotropic virus type i (htlv-i) associated t-cell neoplasms in an htlv-i nonendemic region by polymerase chain reaction. | human t-cell lymphotropic virus type i (htlv-i) associated adult t-cell leukemia/lymphoma (atll) occurs endemically in southwestern japan, the caribbean, and west africa, but occurs sporadically in most of the rest of the world. however, because atll and non-htlv-i associated t-cell neoplasms share overlapping clinicopathologic features, the prevalence of atll in nonendemic regions is unknown. in this study, 75 t-cell neoplasms randomly procured from the metropolitan new york city area were exam ... | 1991 | 2039822 |
| increased calcium uptake in vascular tissue by plasma of patients with essential hypertension. | plasma factors have been implicated in causing increased calcium uptake and cytosolic (ca++) in vascular tissue leading to hypertension. we compared the effect of plasma from hypertensive and normotensive subjects on rat aortic calcium uptake. plasma from hypertensive subjects was fractionated and the fractions assessed for their activity on aortic calcium uptake. aortic calcium uptake was significantly higher in plasma from hypertensives as compared to normotensives (p less than 0.05). there wa ... | 1991 | 2040091 |
| efficacy and safety of recombinant human erythropoietin to prevent the anaemias of prematurity. european randomized multicenter trial. | | 1991 | 2040194 |
| meiotic drive of t haplotypes: chromosome segregation in mice with tertiary trisomy. | the properties of the t haplotypes, specific mutant states of the proximal region of chromosomes 17 in the house mouse, are of continuing interest. one such property is increased transmission of the t haplotype by heterozygous t/+ males to offspring. using the reciprocal translocation t(16;17)43h we have constructed males with tertiary trisomy of chromosome 17 (+t43/+ +/rb7+) carrying the robertsonian translocation rb(16.17)7bnr. only the progeny of these males which had inherited either t43/+ o ... | 1991 | 2040454 |
| effects of a sialoglycopeptide on early events associated with signal transduction. | a sialoglycopeptide (sgp), isolated and purified from bovine cerebral cortex cells, was studied in regard to early signal transduction events associated with the cell cycle. previously shown to be a potent antagonist to a variety of mitogens, the sgp abrogated the ability of 12-o-tetradecanoylphorbol-13 acetate (tpa) to elicit an alkalinization of 3t3 cell cytosol, but only when added minutes prior to, or simultaneously with, the tumor promoter. 3t3 cell tpa-mediated ca2+ mobilization was also i ... | 1991 | 2040660 |
| serologic follow-up of children with sickle cell disease immunized with a haemophilus influenzae type b conjugate vaccine during early infancy. | | 1991 | 2040930 |
| [clinical evaluation of cefixime in pediatric respiratory tract infections]. | cefixime (cfix) was evaluated clinically in pediatric respiratory tract infections, particularly those caused by haemophilus influenzae: 1. the total number of children in this study treated with cfix was 232, out of which 215 cases were evaluated for clinical efficacy and 224 cases were investigated for safety. a daily dosage of 3-6 mg/kg/day was given divided into 2 to 3 times daily for 3-15 days. 2. causative organisms were identified in 146 cases, out of which 128 cases were found to be sing ... | 1991 | 2041146 |
| [bacteriological, pharmacokinetic and clinical evaluations of cefpirome sulfate in the pediatric field. pediatric study group of cefpirome]. | a research group was organized with the purpose of making basic and clinical studies on cefpirome sulfate (hr810, cpr), a newly developed cephalosporin antibiotic, in the pediatric field. through meetings a joint research was done involving 19 key institutions and their related facilities throughout japan. the obtained results are summarized as follows. 1. antibacterial activities minimum inhibitory concentrations (mics) were determined against 71 gram-positive and 110 gram-negative bacteria in ... | 1991 | 2041150 |
| [clinical evaluation of sultamicillin in lower respiratory tract infections]. | clinical efficacy and safety of sultamicillin (sbtpc) in patients with lower respiratory tract infections, mainly pneumonia and bronchitis, have been evaluated in a multicenter trial by 19 institutions in the kyushu area during a period of 12 months from december 1988 to november 1989. 1. clinical evaluation was made in 132 patients and efficacy rates of sbtpc were 80.0% (28/35) for pneumonia, 78.5% (73/93) for bronchitis and 100% for the remaining 1 patient with other respiratory tract infectio ... | 1991 | 2041156 |
| [clinical evaluation of cefpirome in children]. | a new injectable cephem antibiotic, cefpirome (cpr), was evaluated clinically in children. cpr was effective in all the 17 evaluable cases with acute bacterial infections including 1 case of purulent meningitis due to haemophilus influenzae type b. diarrhea and elevation of serum got and gpt were associated with cpr therapy in 2 young infants, although they were mild and transient. the plasma t 1/2 beta of cpr was 1.17 +/- 0.22 hours after bolus injection and mostly excreted in 6 to 8 hours into ... | 1991 | 2041157 |
| [pharmacokinetic and clinical studies on cefpirome in pediatrics]. | cefpirome (cpr, hr 810), a new parenteral cephalosporin antibiotic, was studied for its pharmacokinetics, bacteriological and clinical effects in the field of pediatrics. 1. cpr was very active against staphylococcus aureus, staphylococcus epidermidis, coagulase-negative staphylococci, streptococcus pneumoniae among gram-positive cocci. antibacterial activities of cpr were also strong against branhamella catarrhalis, haemophilus influenzae, escherichia coli, salmonella sp., klebsiella oxytoca, e ... | 1991 | 2041158 |
| [pharmacokinetics and clinical evaluation of cefpirome in children]. | pharmacokinetics and clinical effects of cefpirome (cpr, hr 810) in children were studied. when 20 mg/kg and 40 mg/kg doses of cpr were administered to 4 children through 30 minutes' drip infusion, half-lives were 1.23 +/- 0.23 (mean +/- s.d.) hours and 1.37 +/- 0.35 (mean +/- s.d.) hours, respectively for the 2 dose levels, and recovery rates in urine in the first 6 hours after administration were 74.8% and 56.1%, respectively. cpr was administered to 15 cases (3 tonsillitis, 3 bronchitis, 5 br ... | 1991 | 2041160 |
| [pharmacokinetical and clinical study of cefpirome in children]. | this study describes the pharmacokinetic characteristics and clinical usefulness of cefpirome (cpr) in children. mean half-lives of 20 mg/kg and 40 mg/kg of cpr injected intravenously in one shot were 1.18 and 1.34 hours, respectively, and their mean recovery rates into urine were 69.8 and 72.2%, respectively. minimum inhibitory concentrations of cpr against staphylococcus aureus, streptococcus pneumoniae, klebsiella pneumoniae, escherichia coli and haemophilus influenzae were the same as or low ... | 1991 | 2041162 |
| type b haemophilus influenzae-induced otitis media in the mouse. | to characterize the middle and inner ear cellular inflammatory responses to otitis media using immunohistochemical methods, we inoculated type b haemophilus influenzae into the middle ears of healthy adult balb/c mice. mac-1+ neutrophils and macrophages appeared in the middle ear at 3 days. lyt-1+ t cells and lyt-2+ t suppressor/cytotoxic cells entered the middle ear mucosa on days 7 and 14. igg+ and igm+ t cells were present at all time points, with iga+ lymphocytes forming the majority of muco ... | 1991 | 2041446 |
| molecular cloning, partial purification, and characterization of a haemin-binding lipoprotein from haemophilus influenzae type b. | a library of genomic dna fragments from haemophilus influenzae type b (hib) dl42 was constructed in plasmid pbr322, transformed into escherichia coli strain rr1, and screened for recombinant clones with haemin-binding activity by plating onto haemin-containing agar. expression of haemin-binding activity by clones correlated with the expression of a protein with an apparent molecular weight of 51,000 (51k) that was also recognized by anti-hib strain dl42 serum in immunoblots. one recombinant clon ... | 1991 | 2041470 |
| invasive haemophilus influenzae type b disease in sydney children 1985-1987: a population-based study. | to determine the incidence and age distribution of invasive haemophilus influenzae type b (hib) disease in children (0-14 years) in the sydney statistical division (ssd). | 1991 | 2041512 |
| parapneumonic empyema in children: decortication hastens recovery in patients with severe pleural infections. | the medical records of 61 children 0 to 18 years of age treated for empyema complicating pneumonia from 1977 to 1989 were reviewed with attention to clinical presentation, bacteriology, treatment and outcome. streptococcus pneumoniae was the most common infecting organism, followed by staphylococcus aureus, other streptococcal species, anaerobes, haemophilus influenzae type b, pseudomonas aeruginosa, and eikenella corrodens. no organisms were recovered in 39% of patients. twelve patients were tr ... | 1991 | 2041665 |
| meningitis caused by nontypable haemophilus influenzae in a four-month-old infant. | | 1991 | 2041676 |
| age of initiation of haemophilus b immunization. | | 1991 | 2041679 |
| treatment of meningitis and other infections due to ampicillin-resistant haemophilus influenzae type b in children. | cefotaxime and other cephalosporins were retrospectively evaluated for the treatment of meningitis and non-central nervous system (cns) infections due to ampicillin-resistant haemophilus influenzae type b (hib). between january 1985 and february 1989, 45 cases of meningitis and 27 cases of non-cns infection due to ampicillin-resistant hib were documented at texas children's hospital in houston. of the 45 children with meningitis, 26 (57.8%) were treated with cefotaxime, 11 (24.4%) with chloramph ... | 1991 | 2041948 |
| [respiratory tract infection and acute deterioration of obstructive lung disease]. | respiratory infection may aggravate chronic obstructive pulmonary disease. viral respiratory infections may aggravate asthma, particularly in young individuals. respiratory syncytial virus and rhinovirus dominate in children while, in adults, influenza or rhinovirus infections are most frequently concerned. viral respiratory infections may also cause exacerbation of chronic bronchitis. bacteria and their products scarcely play any part in asthmatic disease but may possibly aggravate chronic bron ... | 1991 | 2042239 |
| [perineal clamping of the everted rectum in conservative coloproctectomy. experimental and clinical results]. | technical alternatives in conservative proctocolectomy are presently investigated to improve the safety and the functional results of the operation. abdominal transection of the rectum is not always satisfactory in this procedure. a new technique of stapled anastomosis is described: after full mobilization and eversion of the rectum, this latter is closed using a linear stapler and cut immediately above the anal canal via a perineal access; a 18 cm long j pouch is constructed and the anastomosis ... | 1991 | 2042916 |
| re: "probability of introducing diseases because of false negative test results". | | 1991 | 2043200 |
| regulation of insulin action at the cellular level. | insulin regulates cellular metabolic reactions by its action on the plasma membrane, intracellular enzymes and the nucleus. the first stage in the propagation of the insulin signal is the coupling of insulin to specific receptors at the cell surface. the exact mechanism whereby the transmembrane signalling mechanism (s) results in different insulin-mediated cellular effects is not known. however, the insulin receptor tyrosine kinase, the expression of second messengers, and the action of protein ... | 1991 | 2043221 |
| dietary n-3 fatty acids do not affect induction of ha-ras mutations in mammary glands of nmu-treated rats. | the purpose of this study was to determine whether dietary n-3 polyunsaturates (pufa) can affect the frequency of n-nitrosomethylurea (nmu)-induced ha-ras mutations in virgin female f344 rat mammary glands. two groups of 15 rats each were fed isocaloric diets containing either 23% w/w corn oil or corn oil plus menhaden oil (1:1) at starting 14 d before nmu administration (day 50 of age) and continuing for 13 wk. mammary gland samples were taken serially at 3, 5, 9, and 13 wk post-nmu treatment. ... | 1991 | 2043252 |
| fluorescent laser scanning microscopy of f-actin disruption in human endometrial stromal cells expressing the sv40 large t antigen and the ej ras oncogene. | to attempt to understand the effects of the sv40 large t antigen and an activated ej ras oncogene on f-actin organization, we compared normal human endometrial stromal cells (hesc; proliferating, short life span) to cells transfected with the sv40 large t antigen either alone or in combination with the ej ras oncogene. normal hesc displayed numerous bundles of actin filaments (stress fibers) evenly distributed throughout the cell. in hesc transfected with a plasmid containing the gene for a temp ... | 1991 | 2043268 |
| the athymic nude rat. immunobiological characteristics with special reference to establishment of non-antigen-specific t-cell reactivity and induction of antigen-specific immunity. | the aim of the present review has been to describe some immunobiological characteristics of the athymic nude rat and on the basis of these to describe the possibilities of establishing non-antigen-specific t-cell reactivity and inducing antigen-specific immunity. after a brief introduction, some general characteristics of the autosomal recessive rnu/rnu rat are outlined. this athymic mutant normally has a longer lifespan than athymic nude mice and is easier to breed. inbred nude rats are now ava ... | 1991 | 2043379 |
| sir frederick hobday memorial lecture. all wind and water: some progress in the study of equine gut motility. | | 1991 | 2044514 |
| preferential denervation of the adductor muscles of the equine larynx. i: muscle pathology. | the laryngeal muscles of 18 horses were examined histologically. the neurogenic changes found in each muscle were scored by four reviewers and the results evaluated statistically. fifteen of these horses had endoscopic evidence of abnormal laryngeal function, three of which were defined as having adductor paralysis. measurement of muscle fibre area in two horses with idiopathic laryngeal hemiplegia (ilh) was performed. in the quantitative study of neurogenic change, the adductor muscles were mor ... | 1991 | 2044516 |
| modulation of skin sensitivity by dynamic and isometric exercise in man. | the effect of dynamic cycle ergometer exercise and isometric leg exercise on skin sensitivity was studied in man. exercise was performed at different loads. cutaneous sensitivity to innocuous and noxious thermal stimuli was tested using a contact thermostimulator and sensitivity to tactile stimuli was tested using electrical stimuli. during isometric exercise a segmental (the exercising limb), but not a multisegmental, phasic decrease of cutaneous thermal sensitivity to innocuous stimuli was fou ... | 1991 | 2044539 |
| haemophilus influenzae epiglottitis occurring simultaneously in two siblings. | intrafamilial spread of haemophilus influenzae type b disease has often been described for meningitis, but rarely for epiglottitis. here we report for the first time epiglottitis occurring simultaneously in two siblings and comment on the value of chemoprophylaxis and vaccination to prevent secondary and primary disease. | 1991 | 2044588 |
| septic arthritis associated with haemophilus influenzae meningitis. | | 1991 | 2044597 |
| enhanced chloride reabsorption in the loop of henle in dahl salt-sensitive rats. | this study examines the nephron segments contributing to the blunted pressure-natriuretic response in dahl salt-sensitive rats. urine and late proximal and early distal tubular fluid samples were collected from 16-20-week-old, inbred dahl salt-sensitive (ds/jr) and salt-resistant (dr/jr) rats, and dahl salt-sensitive (ds) and salt-resistant (dr) rats from the brookhaven colony, that were maintained from birth on a low (0.3%) sodium chloride diet. urine flow and sodium and chloride excretions wer ... | 1991 | 2045146 |
| juxtamedullary afferent arteriolar responses to p1 and p2 purinergic stimulation. | we assessed the responsiveness of rat juxtamedullary afferent arterioles to purinergic stimulation using the in vitro blood-perfused juxtamedullary nephron technique combined with videomicroscopy to allow direct measurement of arteriolar inside diameter. to minimize the contribution of endogenously formed angiotensin ii, all rats were pretreated with enalaprilat (2 mg i.v.) for 30 minutes before the right kidney was isolated and prepared for study. renal perfusion pressure was set at 110 mm hg a ... | 1991 | 2045147 |
| contribution of regional vascular responses to whole body autoregulation in conscious areflexic rats. | we designed studies to evaluate the autoregulation response during volume expansion in three major circulation regions (intestine, kidney, and hind limb) during simultaneous determination of whole body autoregulation in conscious areflexic rats. cardiac output was measured with chronically implanted electromagnetic flow probes on the ascending aorta. regional blood flow velocity was measured with pulsed doppler flow probes on the superior mesenteric (n = 7), left renal (n = 7), and right iliac ( ... | 1991 | 2045152 |
| constitutive expression and secretion of proteases in non-metastatic sp1 mammary carcinoma cells and its metastatic sublines. | malignant tumors are generally characterized by extensive local tissue invasion and destruction of ecm which may be due to increased constitutive expression and activity of secreted proteases. moreover, a large number of diverse protease activities may be constitutively over-expressed in a simultaneous or co-ordinated fashion, thereby significantly increasing cellular invasive potential of the cells. to explore this relationship, we have measured steady-state levels of mrna coding for urokinase ... | 1991 | 2045200 |
| fumonisin mycotoxins and equine leukoencephalomalacia. | | 1991 | 2045319 |
| two new genes located between 2758 and 2761 kilobase pairs on the escherichia coli genome. | | 1991 | 2045357 |
| [primary immune deficiencies of b-lymphocytes]. | primary b-cell immunodeficiency is relatively frequent and may result in recurrent bacterial infections involving notably the respiratory tract, and in chronic severe enteroviral infections in patients with agammaglobulinaemia. selective igg2 isotype deficiency results in pneumococcal, haemophilus influenzae and pseudomonal infections, since it is associated with defective production of antibodies that are specifically directed against bacterial capsular polysaccharides. progress has recently be ... | 1991 | 2047714 |
| open randomized controlled parallel study of ofloxacin versus trimethoprim-sulfamethoxazole treatment of lower respiratory tract and urinary infections. | a total of 60 patients with lower respiratory tract or urinary tract infections were enrolled in an open, randomized, controlled, parallel study comparing 300 mg ofloxacin (ofx) b.i.d. with trimethoprim + sulfamethoxazole (tmp 800 mg + smx 160 mg), 1 tablet, b.i.d. the signs and symptoms of low respiratory tract infection were cured in 12 patients (80%) of the ofx group and improved in 2 other patients (13%); at the end of therapy, the 2 germs that persisted were streptococcus pneumoniae and bra ... | 1991 | 2049964 |
| the distribution of particles characterized by size and free mobility within polydisperse populations of protein-polysaccharide conjugates, determined from two-dimensional agarose electropherograms. | new approaches for the characterization of polydisperse particle populations are presented*. the investigated samples contain virus-sized protein-polysaccharide conjugates which had previously been prepared as immunogens against bacterial meningitis (hib). the analysis is based on two-dimensional agarose electrophoresis (serwer-type). this method, like the one of o'farrell, achieves a separation according to size and charge. it relies on a different principle, however, and is applicable to nonde ... | 1991 | 2050099 |
| chemotherapy for infections caused by haemophilus influenzae: current problems and future prospects. | | 1991 | 2050595 |
| haemophilus influenzae resistance in a community hospital. | we prospectively tabulated all isolates of haemophilus influenzae at dekalb medical center from 1987 through 1989 to assess the occurrence of antibiotic resistance in patients of different ages. of 325 total strains isolated, 24% produced beta-lactamase, rendering them resistant to ampicillin and amoxicillin. antibiotic resistance was as common in patients older than age 60 (24%) as in younger patients (23%). sensitivity testing by disk diffusion and microdilution techniques on 71 isolates (37 b ... | 1991 | 2052962 |
| septic arthritis due to haemophilus influenzae in a patient with hiv infection. | | 1991 | 2054974 |
| antibiotic resistance in haemophilus influenzae isolated from patients with cancer. | | 1991 | 2055816 |
| differences in subtype distribution of haemophilus influenzae type b from carriers in the general population and patients with meningitis. | twenty-four haemophilus influenzae type b strains from 836 children and young adults in an open population were subtyped by outer-membrane-protein (omp) analysis on sodium dodecyl sulphate-polyacrylamide gels, lipopolysaccharide serotyping and biotyping. the results were compared with those obtained with h. influenzae type b strains from 97 patients with meningitis in the same city (amsterdam). omp subtype 1 was significantly more common among the csf isolates than in carrier strains (82% vs 50% ... | 1991 | 2056515 |
| american academy of pediatrics committee on infectious diseases: haemophilus influenzae type b conjugate vaccines: recommendations for immunization of infants and children 2 months of age and older: update. | | 1991 | 2057256 |
| [adult haemophilus influenzae arthritis and chondrocalcinosis. apropos of 2 cases]. | | 1991 | 2057733 |
| the role of viruses and atypical organisms in the pathogenesis of adult pneumonia in papua new guinea. | the role of viruses and atypical organisms in pneumonia is well known in western populations, yet very little documentation is available about their role in pneumonia in developing countries. in a study of 175 adults with community-acquired pneumonia in papua new guinea, serological methods were used to assess this issue. five patients had high influenza a titres suggestive of recent infection. adenovirus titres rose significantly in one patient with haemophilus influenzae pneumonia, whilst no e ... | 1991 | 2058297 |
| dose-related immunogenicity of haemophilus influenzae type b capsular polysaccharide-neisseria meningitidis outer membrane protein conjugate vaccine. | we studied the immunologic responsiveness to haemophilus influenzae type b capsular polysaccharide-neisseria meningitidis group b outer membrane protein conjugate vaccine (prp-nomp) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 micrograms of prp. overall, prp-nomp was highly immunogenic. geometric mean titers of anti-prp antibody increased from 0.09 to 3.3 mg/l and 6.6 mg/l following each dose of vaccine, respectively, in the 2- to 18-month age group. similarly ... | 1991 | 2058604 |
| dtp immunization and susceptibility to infectious diseases. is there a relationship? | a two-part study was carried out in alaskan native children to evaluate the potential risk of invasive bacterial disease and the occurrence of minor illnesses after immunization with diphtheria and tetanus toxoids and whole-cell pertussis vaccine (dtp). first, a case-control comparison was performed with 186 children who had invasive haemophilus influenzae type b or streptococcus pneumoniae disease (cases) and 186 healthy controls matched for sex, region of residence, birth date, and number of d ... | 1991 | 2058605 |
| inhibition of bacterial adherence by nasopharyngeal secretions. | the role of secretory immunoglobulin (ig) a in nasopharyngeal secretions in the adherence of streptococcus pneumoniae and hemophilus influenzae to nasopharyngeal epithelial cells was investigated in vitro. the adherence was remarkably reduced by treating bacteria with nasopharyngeal secretions, and the antiadhesive activity was significantly greater in nasopharyngeal secretions having secretory iga antibody activity against bacteria than in those having no activity. noticeable changes were not o ... | 1991 | 2058985 |
| haemophilus influenzae type b infections: secondary cases and recurrent disease. | invasive haemophilus influenzae type b infections in denmark have not been known to lead to secondary cases, and recurrent disease has not been observed. three case histories are presented and the literature reviewed. secondary disease occurs more often among household contacts than among day-care contacts, which probably is due to genetic factors. the same factors might also influence the risk of contracting recurrent disease. parents should be informed of the risk and promptly have their child ... | 1991 | 2060323 |
| elisa procedures for the measurement of igg subclass antibodies to bacterial antigens. | we have developed enzyme-linked immunosorbent assays (elisa) of igg subclass antibodies against whole bacteria and bacterial antigens using enzyme-labelled mouse monoclonal antibodies. the properties of different anti-subclass antibodies were compared. in sera from 18 healthy adults we measured the igg subclass distribution of specific antibodies against staphylococcus aureus and haemophilus influenzae b and against distinct bacterial components: pneumococcal capsular polysaccharides, dextran an ... | 1991 | 2061615 |
| antibody response to outer membrane of noncapsulated haemophilus influenzae isolated from the nasopharynx of children with pneumonia. | in a prospective study aimed at determining the etiology of community-acquired pneumonia in children nasopharyngeal cultures and paired serum samples were obtained from 336 consecutive children ages 6 weeks to 15 years with pneumonia, 167 hospitalized and 169 outpatients. results regarding haemophilus influenzae are reported here. blood cultures obtained from 127 of the hospitalized patients did not yield growth of h. influenzae. h. influenzae was isolated from the nasopharynx of 88 children. se ... | 1991 | 2062599 |
| prospective comparison of the immune response of infants to three haemophilus influenzae type b vaccines. | the antibody response to three haemophilus influenzae type b vaccines was examined in 134 infants 17 to 22 months of age. sera were collected from each subject before and 1 month after vaccination with either purified h. influenzae type b capsular polysaccharide (polyribosyl-ribitol phosphate (prp] or one of two protein-conjugated vaccines (prp-d or hboc). comparison of the two conjugate vaccines revealed that hboc produced an antibody response greater than or equal to 1.0 micrograms/ml in 96% c ... | 1991 | 2062600 |
| safety and immunogenicity of a haemophilus influenzae type b conjugate vaccine in a high risk american indian population. | the safety and immunogenicity of a haemophilus influenzae type b polysaccharide conjugate vaccine linked to the outer membrane protein complex of neisseria meningitidis (hib-omp) were evaluated among apache and navajo infants and children. one dose of the hib-omp was given to 42 children who were from 12 and 60 months of age. ninety-two infants 6 to 8 weeks old were given one dose of hib-omp at the time of enrollment. a subsequent dose of the vaccine was given 2 months later and a third dose was ... | 1991 | 2062601 |
| imipenem/cilastatin treatment of bacterial meningitis in children. | the safety and efficacy of imipenem/cilastatin were evaluated in 21 children, ages 3 to 48 months, with bacterial meningitis. eradication of bacteria from the cerebrospinal fluid was demonstrated within 24 hours of antibiotic therapy in all but 2 patients who had haemophilus influenzae type b meningitis and ultimately achieved bacteriologic cure after 2 to 3 days of imipenem/cilastatin therapy. cerebrospinal fluid penetrations of imipenem and cilastatin were determined at various times after dru ... | 1991 | 2062603 |
| haemophilus influenzae type b vaccine in children with sickle cell disease: antibody persistence after vaccination at age one and one-half to six years. | | 1991 | 2062609 |
| pleuropneumonia caused by multiply resistant haemophilus influenzae type b infection acquired in the united states. | | 1991 | 2062611 |
| the 1990s: a decade of new vaccines. | | 1991 | 2062619 |
| safety and immunogenicity of oligosaccharide conjugate haemophilus influenzae type b (hboc) vaccine in infancy. the northern california kaiser permanente vaccine study center pediatrics group. | the safety and immunogenicity of the hboc conjugate vaccine have been evaluated in a study population of 61,080 children in the kaiser permanente medical care program of northern california. half of the population served as controls. the vaccine was given as part of a three-dose regimen in the first year of life with the first dose given between 6 weeks and 6 months of age, a minimum interval of 1 month between doses and with the third dose given by 1 year of age. the vaccine was highly immunoge ... | 1991 | 2062620 |
| efficacy in infancy of oligosaccharide conjugate haemophilus influenzae type b (hboc) vaccine in a united states population of 61,080 children. the northern california kaiser permanente vaccine study center pediatrics group. | the efficacy of the hboc conjugate haemophilus influenzae type b vaccine was evaluated in a study population of 61,080 infants in the northern california kaiser permanente medical care program. between february, 1988, and june, 1990, the hboc vaccine was given as part of a three-dose series at 2, 4, and 6 months of age to 20,800 infants. the study population included children with a well-care visit at a study center during the first 6 months of life. there were 25 cases of haemophilus influenzae ... | 1991 | 2062621 |
| comparison of antigenuria after immunization with three haemophilus influenzae type b conjugate vaccines. | the incidence of antigenuria was documented after vaccination of 75 children 15 to 60 months of age with one of three haemophilus influenzae type b conjugate vaccines, prp-d (prohibit), prp-t and hboc (hibtiter). unconcentrated and concentrated urine was tested on the first, third, fifth and seventh days after vaccination. antigenuria occurred on day 1 in 100% of prp-d, 43% of prp-t and 12% of hboc recipients. the percentages of children excreting antigen on day 3 were 95, 17 and 8%; on day 5 th ... | 1991 | 2062627 |
| viability testing by 48-hour 1h-nmr-relaxometry in rat livers preserved in university of wisconsin solution. | | 1991 | 2063455 |
| viability testing by 48-hour 1h-nmr-relaxometry in rat livers preserved in university of wisconsin solution. | | 1991 | 2063455 |
| transcriptional regulation of a yeast hsp70 gene by heat shock factor and an upstream repression site-binding factor. | ssa1, one of the heat-inducible hsp70 genes in the yeast saccharomyces cerevisiae, displays a significant basal level of expression under optimal growth conditions. although multiple sites related to the heat shock element (hse) consensus sequences are present in the ssa1 promoter region, one of these, hse2, plays a key role in basal expression. an upstream repression site (urs) located adjacent to hse2 causes repression of basal expression but has little effect on heat-inducible expression of s ... | 1991 | 2065978 |
| isolation accelerates reproductive senescence and alters its predictors in female rats. | the process of reproductive senescence in female rats (rattus norvegicus, sprague-dawley strain) was altered by their social environment during adulthood. the incidence of constant estrus (ce), which marks the end of estrous cyclicity, was nearly twice as high in females living in isolation as it was in females living in groups. isolated females also entered ce at three times the rate of group-housed females. in addition, the characteristics of a rat's estrous cycle when she was young predicted ... | 1991 | 2066084 |
| triple trisomy in a 17-week-old fetus. | autosomal trisomies account for the majority of chromosome abnormalities associated with spontaneous miscarriages. occasionally, double autosomal trisomies are found to be present in abortuses. this report describes the second occurrence of triple trisomy associated with fetal demise. | 1991 | 2066117 |
| epidemiology of invasive haemophilus influenzae type b infections in geneva, switzerland, 1976 to 1989. | we report a retrospective study of invasive haemophilus influenzae type b (hib) diseases in geneva from 1976 to 1989. among the 183 children who fulfilled the case definition, 6 (3.3%) presented with more than one site of infection. the overall incidence rate among children younger than 5 years of age was 60.2/100,000 but it was 92.1/100,000 in 1989. forty-one percent of patients had meningitis, 37% had epiglottis and 22% had other forms of hib infections. fifty-four percent of cases occurred in ... | 1991 | 2067887 |
| psoas abscess caused by haemophilus influenzae type b. | | 1991 | 2067895 |
| aztreonam in the treatment of gram-negative bacterial meningitis. | aztreonam was administered to 122 patients with presumptive or confirmed gram-negative bacillary meningitis in an open, multinational study. the antibiotic was administered at a dosage of 1-2 g to adults, 50 mg/kg to children greater than 2 years old, and 30 mg/kg to infants three or four times daily. seventy-seven patients had microbiologically confirmed gram-negative meningitis due to an aztreonam-susceptible organism and received aztreonam for at least 48 hours. haemophilus influenzae was the ... | 1991 | 2068463 |
| [posttraumatic purulent meningitis in patients treated at the clinic for infectious diseases at the rijeka clinical center, 1980-1989]. | during the period from 1980 to 1989 seven patients with posttraumatic purulent meningitis (ptpm) were treated at the clinic for infectious diseases of rijeka clinical centre. these accounted for 11.1% of total purulent meningitis cases of the same period. three ptpm patients had recurrent attacks of meningitis. the age range of was the ptpm patients from 5 to 49 years; men prevailed in the ratio of 6 to 1. the etiology was confirmed in five cases (in four streptococcus pneumoniae, in one haemoph ... | 1991 | 2070032 |
| rifampicin prophylaxis for throat carriage of haemophilus influenzae type b in patients with invasive disease and their contacts. | to determine rates of colonisation with haemophilus influenzae type b among household contacts of children with invasive h influenzae type b disease; compliance among medical staff with recommendations for use of rifampicin prophylaxis; and effects of rifampicin treatment in h influenzae type b colonisation of patients and contacts. | 1991 | 2070109 |
| spontaneous splenic rupture in haemophilus influenzae septicemia. | | 1991 | 2071771 |
| high recovery of haemophilus influenzae and group a streptococci in recurrent tonsillar infection or hypertrophy as compared with normal tonsils. | one hundred and twenty-six patients who underwent tonsillectomy because of recurrent acute tonsillitis, tonsillar hypertrophy or sleep apnoea were evaluated by tonsillar core culturing. the sleep apnoea patients served as controls, since none of them had tonsillar hypertrophy at ent examination or any history of recurrent acute tonsillitis, and thus their tonsillar core flora could be regarded as normal. the isolation rate of h. influenzae was much lower among sleep apnoea controls (2.7 per cent ... | 1991 | 2072011 |
| in vitro activity of tosufloxacin, a new quinolone, against respiratory pathogens derived from cystic fibrosis sputum. | by using broth microdilution methods, the in vitro activity of tosufloxacin (a-64730), a new quinolone, was compared with those of other agents, including five quinolones, against geographically diverse cystic fibrosis sputum isolates obtained from 26 cystic fibrosis centers in the united states. these included pseudomonas aeruginosa, conventional as well as especially resistant (ceftazidime, aztreonam, gentamicin, and/or tobramycin) isolates: escherichia coli; pseudomonas cepacia; staphylococcu ... | 1990 | 2073112 |
| rapid testing of susceptibility of haemophilus influenzae to chloramphenicol by a bioluminescence method. | | 1990 | 2073906 |
| [survey on clinical isolates from 13 hospitals in akita prefecture--changes in frequency and susceptibility of isolates by scale of hospital. survey group for clinical isolates, chemotherapy research committee of akita prefecture]. | isolates from various clinical materials in 13 hospitals in akita prefecture and their drug susceptibility were investigated by the chemotherapy research committee of akita prefecture during the period from dec., 1987 to feb., 1988. the results were as follows: 1. the total number of isolates was 8,387, including staphylococcus aureus (18.9%), pseudomonas aeruginosa (10.9%), staphylococcus epidermidis (7.3%) and enterococcus faecalis (6.6%). s, aureus and p. aeruginosa were detected more frequen ... | 1990 | 2074368 |
| serum fructosamine and lipid profile in type i diabetic children in turkey. | serum levels of total cholesterol (tc), triglycerides (tg), lipoprotein cholesterol fractions (hdl-c and ldl-c) and fructosamine (fa) were determined in twenty-three children with type i diabetes and twenty healthy children aged 4-14 years. mean serum tc and hdl-c did not differ significantly between diabetic and nondiabetic children. mean serum tg and fa showed a statistically significant increase in the diabetic group compared to healthy children. it is interesting to note that extremely high ... | 1990 | 2075022 |
| [recurrent thromboembolism disclosing protein c deficiency. apropos of a case with familial investigation]. | every thromboembolic manifestation, especially in young subjects, calls for an aetiological study in which haemostasis is evaluated primarily with assays of physiological coagulation inhibitors: protein c, protein s and antithrombin iii. protein c deficiency is found in 6 to 7% of thromboembolic manifestations. we report the case of a 21-year old man who had phlebitis followed by pulmonary embolism without facilitating factors. protein c level was 50% of normal value (0.50 iu/ml). the patient re ... | 1990 | 2075365 |
| antimicrobial susceptibility of clinical isolates of haemophilus influenzae to ampicillin-sulbactam. | a total of 1092 clinical isolates of haemophilus influenzae (306 type b; 786 non-type-b), from five medical centers were obtained during 1987 and 1988. disk diffusion antimicrobial susceptibilities were obtained for all isolates, and broth microdilution susceptibilities were obtained for 502 isolates. beta-lactamase was produced by 34.3% of type-b and 22.1% of non-type-b isolates, with some geographic variations. using disk diffusion antimicrobial susceptibility testing, all isolates were suscep ... | 1990 | 2076596 |
| increased ampicillin resistance in haemophilus influenzae in northern ireland hospitals. | twenty-nine of one hundred and ninety-three (15%) clinical isolates of haemophilus influenzae from northern ireland hospitals during 1985-1986 were found to be ampicillin resistant. this is twice the national average for the same period and 65% increase since a similar report in northern ireland three years previously. computerised monitoring of routine specimens has shown this resistance level to be maintained in 1989. susceptibility to other antimicrobials is discussed. | 1990 | 2076942 |
| [tuberculosis sequelae: secondary bacterial infections]. | bacterial infections is one of the most important complications in the patients with pulmonary tuberculosis. we reported the causative microorganisms in these cases with special reference to various clinical features and presented the recommended treatment and prophylaxis against respiratory bacterial infections in the patients with pulmonary tuberculosis sequelae. in 1988 and 1989, 63 patients with tuberculosis sequela were demonstrated to have been infected with respiratory pathogenic bacteria ... | 1990 | 2077264 |
| [haemophilus infection in nonspecific inflammatory lung diseases]. | hemophilic infection incidence rate, characteristics and criteria of early detection were studied in 393 patients with nonspecific pulmonary diseases. h. influenzae represented the prevalent pathogenic agent in 17% of the cases: in 11% of acute pneumonias (276 patients) and 30% of chronic bronchitis exacerbations (117 patients). hemophilic pneumonias were a more frequent finding in patients over 40 years of age, proved secondary, manifested usually interstitial inflammation of the lung tissue, w ... | 1990 | 2077276 |