| identification of the phosphorylated residues in tveif5a by mass spectrometry. | the initiation factor eif5a in trichomonas vaginalis (tveif5a) is previously shown to undergo hypusination, phosphorylation and glycosylation. three different pi isoforms of tveif5a have been reported. the most acidic isoform (pi 5.2) corresponds to the precursor tveif5a, whereas the mature tveif5a appears to be the most basic isoform (pi 5.5). in addition, the intermediary isoform (pi 5.3) is found only under polyamine-depleted conditions and restored with exogenous putrescine. we propose that ... | 2013 | 24308916 |
| utility of microbiological profile of symptomatic vaginal discharge in rural women of reproductive age group. | symptomatic vaginal discharge is the most frequent symptom in women of reproductive age group. owing to social stigma majority of affected women hesitate to seek medical consultation. therefore the actual incidence of vaginal discharge is much more than what is reported. the aim of the study is to determine the microbiological profile of symptomatic vaginal discharge in rural area and its utility in the management of genital tract infection. | 2015 | 25954668 |
| anaerobic respiration: in vitro efficacy of nitazoxanide against mitochondriate acanthamoeba castellanii of the t4 genotype. | acanthamoeba is an opportunistic protist pathogen that is responsible for serious human and animal infection. being one of the most frequently isolated protists from the environment, it is likely that it readily encounters microaerophilic environments. for respiration under anaerobic or low oxygen conditions in several amitochondriate protists, decarboxylation of pyruvate is catalyzed by pyruvate ferredoxin oxidoreductase instead of pyruvate dehydrogenase. in support, nitazoxanide, an inhibitor ... | 2015 | 26297676 |
| screening for abnormal vaginal microflora by self-assessed vaginal ph does not enable detection of sexually transmitted infections in ugandan women. | is self-assessed vaginal ph measurement to detect abnormal vaginal bacterial microflora (avf) an adequate prescreening method for detection of genital sexually transmitted infections (stis)? | 2016 | 27112831 |
| bead-based multiplex sexually transmitted infection profiling. | sexually transmitted infections are a significant cause of genital disease, infertility and hospital admissions. the economic impact is high. an accurate diagnosis is often difficult and time consuming. we report the development and validation of a novel bead-based multiplex sexually transmitted infection profiling (stip) assay that detects 18 sexually transmitted infections using a multiplex pcr followed by luminex bead-based hybridisation. | 2014 | 24814157 |
| the villain team-up or how trichomonas vaginalis and bacterial vaginosis alter innate immunity in concert. | complex interactions of vaginal microorganisms with the genital tract epithelium shape mucosal innate immunity, which holds the key to sexual and reproductive health. bacterial vaginosis (bv), a microbiome-disturbance syndrome prevalent in reproductive-age women, occurs commonly in concert with trichomoniasis, and both are associated with increased risk of adverse reproductive outcomes and viral infections, largely attributable to inflammation. to investigate the causative relationships among in ... | 2013 | 23903808 |
| correlation of atopobium vaginae amount with bacterial vaginosis markers. | the purpose of this study was to test the correlation of the amount of atopobium vaginae with the most commonly used markers for bacterial vaginosis (bv). | 2012 | 22371042 |
| genome mining offers a new starting point for parasitology research. | parasites including helminthes, protozoa, and medical arthropod vectors are a major cause of global infectious diseases, affecting one-sixth of the world's population, which are responsible for enormous levels of morbidity and mortality important and remain impediments to economic development especially in tropical countries. prevalent drug resistance, lack of highly effective and practical vaccines, as well as specific and sensitive diagnostic markers are proving to be challenging problems in p ... | 2015 | 25563615 |
| antibacterial, antiviral, and antifungal properties of wines and winery byproducts in relation to their flavonoid content. | grapes produce organic compounds that may be involved in the defense of the plants against invading phytopathogens. these metabolites include numerous phenolic compounds that are also active against human pathogens. grapes are used to produce a variety of wines, grape juices, and raisins. grape pomace, seeds, and skins, the remains of the grapes that are a byproduct of winemaking, also contain numerous bioactive compounds that differ from those found in grapes and wines. this overview surveys an ... | 2014 | 24945318 |
| expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity. | metronidazole and other 5-nitroimidazoles (5-ni) are among the most effective antimicrobials available against many important anaerobic pathogens, but evolving resistance is threatening their long-term clinical utility. the common 5-nis were developed decades ago, yet little 5-ni drug development has since taken place, leaving the true potential of this important drug class unexplored. here we report on a unique approach to the modular synthesis of diversified 5-nis for broad exploration of thei ... | 2013 | 24101497 |
| [role of infectious agents in the emergence of malignant tumors]. | according to the data of the international agency for research on cancer (iarc), at least 6 virus species (hpv, ebv, hhv-8/kshv, htlv-1, hbv, hcv), 4 helminthes species (schistosoma haematobium and japonicum, opisthorchis viverrini, clonorchis sinensis) and i bacterium species (helicobacter pylori) have been proved to be capable of causing the development of cancer. the analysis of the data available shows that merkel cell polyomavirus (mcv), herpes simplex virus (hsv), john cunningham polyomavi ... | 2012 | 23163048 |
| highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa. | the mitochondria have arisen as a consequence of endosymbiosis of an ancestral α-proteobacterium with a methane-producing archae. the main function of the canonical aerobic mitochondria include atp generation via oxidative phosphorylation, heme and phospholipid synthesis, calcium homeostasis, programmed cell death, and the formation of iron-sulfur clusters. under oxygen-restricted conditions, the mitochondrion has often undergone remarkable reductive alterations of its content and function, lead ... | 2014 | 24316280 |
| prevalence of trichomonas vaginalis and candida albicans among brazilian women of reproductive age. | there are no studies assessing the simultaneous occurrence of candida albicans (c. albicans) and trichomonas vaginalis (t. vaginalis) in the primary health care in brazil. despite different conditions to establishment of each one, the co-detection of both has been reported by some authors in previous studies from other regions. | 2016 | 28050410 |
| loop-mediated isothermal amplification (lamp) assay for the rapid detection of the sexually-transmitted parasite, trichomonas vaginalis. | a loop-mediated isothermal amplification (lamp) assay was developed to detect the sexually-transmitted parasite, trichomonas vaginalis in vaginal swabs. the presence of t. vaginalis was detected from 121 female sex workers attending a social hygiene clinic in balibago, angeles city, pampanga, philippines using culture, polymerase chain reaction (pcr), and the developed lamp assay. the high analytical sensitivity of lamp detected a higher prevalence of t. vaginalis (42.06%) compared to culture (8 ... | 2016 | 27262954 |
| a prospective observational study of vulvovagintis in pregnant women in argentina, with special reference to candidiasis. | to evaluate the frequency of yeast, bacteria or protozoa in pregnant women and to correlate the possible associations of these microorganisms and their relationships with vulvovaginitis (vv) and cervicitis. vaginal specimens were collected and prepared for smears in microscope slides for the evaluation of yeast, trichomonas vaginalis and bacteria. samples were cultured in specific culture medium. cervical specimens were used to investigate the presence of neisseria gonorrhoeae, chlamydia trachom ... | 2016 | 26931504 |
| affirm vpiii microbial identification test can be used to detect gardnerella vaginalis, candida albicans and trichomonas vaginalis microbial infections in korean women. | the aim of this study was to compare affirm vpiii microbial identification test results for korean women to those obtained for gardnerella vaginalis through nugent score, candida albicans based on vaginal culture and trichomonas vaginalis based on wet smear diagnostic standards. | 2016 | 26787446 |
| ammonium salts of carbamodithioic acid as potent vaginal trichomonacides and fungicides. | chemical attenuation of the reactive oxygen species (ros)-sensitive anaerobes trichomonas vaginalis, which is the most prevalent non-viral sexually transmitted infection, and two often coexisting vaginal infections, namely candida albicans and staphylococcus aureus, which are opportunistic reproductive tract infections, was attempted with novel ammonium salts of carbamodithioic acid through inhibition of free thiols. in vitro and in vivo efficacies of the designed compounds were evaluated as top ... | 2016 | 26706422 |
| sexually transmitted pathogens, depression, and other manifestations associated with premenstrual syndrome. | this study investigated whether sexually transmitted infections and lifestyle variables are associated with premenstrual syndrome (pms) as well as particular manifestations commonly associated with pms. data were gathered from medical records of 500 regularly cycling women. the following infectious agents were investigated: human papillomavirus, chlamydia trachomatis, neisseria gonorrheae, gardnerella vaginalis, candida albicans, and trichomonas vaginalis. bivariate tests and multivariate logist ... | 2015 | 26272230 |
| value of bacterial culture of vaginal swabs in diagnosis of vaginal infections. | vaginal and cervical swab culture is still very common procedure in our country's everyday practice whereas simple and rapid diagnostic methods have been very rarely used. the aim of this study was to show that the employment of simple and rapid diagnostic tools [vaginal fluid wet mount microscopy (vfwmm), vaginal ph and potassium hydroxide (koh) test] offers better assessment of vaginal environment than standard microbiologic culture commonly used in serbia. | 2015 | 26226725 |
| clinical characteristics of aerobic vaginitis and its association to vaginal candidiasis, trichomonas vaginitis and bacterial vaginosis. | examine clinical characteristics of aerobic vaginitis and mixed infection for the purpose of better diagnostic accuracy and treatment efficiency. | 2013 | 25568514 |
| performance evaluation of a dna chip assay in the identification of major genitourinary pathogens. | to prevent the recurrence of genitourinary infections and to reduce the risks of their complications, accurate and rapid diagnosis are required. stdetect® chip is a dna chip which allows for the simultaneous detection of 13 major genitourinary pathogens in a single vaginal swab or urine specimen. we evaluated the analytical performance of the stdetect® chip for detecting target pathogens that commonly cause genitourinary infections. | 2015 | 25533217 |
| development of a loop-mediated isothermal amplification assay for detection of trichomonas vaginalis. | a loop-mediated isothermal amplification (lamp) assay targeting the 2-kbp repeated dna species-specific sequence was developed for detection of trichomonas vaginalis, the causative agent of trichomoniasis. the analytical sensitivity and specificity of the lamp assay were evaluated using pooled genital swab and urine specimens, respectively, spiked with t. vaginalis trophozoites. genital secretion and urine did not inhibit the detection of the parasite. the sensitivity of the lamp was 10-1000 tim ... | 2014 | 24792836 |
| vaginal infections among pregnant women at omdurman maternity hospital in khartoum, sudan. | microbial infections of the vagina in pregnant women are health problems that lead to serious medical complications and consequences. this study aimed to investigate and determine antimicrobial susceptibilities of the causative agents of vaginal infections in pregnant women. | 2014 | 24727516 |
| population-based cervical screening outcomes in turkey over a period of approximately nine and a half years with emphasis on results for women aged 30-34. | to appraise the frequency of cervical cytological abnormalities in a population at normal risk via analysing the archive records of cytology for the period of approximately 9,5 years, comparing them with patient demographic charecteristics, and discuss the results for women under age of 35. | 2014 | 24716936 |
| azole-carbodithioate hybrids as vaginal anti-candida contraceptive agents: design, synthesis and docking studies. | azole and carbodithioate hybrids were synthesized as alkyl 1h-azole-1-carbodithioates (7-27) and evaluated for spermicidal/microbicidal activities against human sperm, trichomonas vaginalis and candida species. seventeen compounds (7-14, 16-18 and 20-25) showed spermicidal activity at mec 1.0% (w/v) and permanently immobilized 100% normal human spermatozoa within ∼30 s. seventeen compounds (7-11, 13-18 and 20-25) exhibited anti-candida activity (ic50 1.26-47.69 μg/ml). all compounds were devoid ... | 2013 | 24140949 |
| plants traditionally used individually and in combination to treat sexually transmitted infections in northern maputaland, south africa: antimicrobial activity and cytotoxicity. | although medicinal plants are used extensively to treat sexually transmitted infections (stis) in rural northern maputaland, kwazulu-natal, the efficacy and safety of these plants have not previously been evaluated. | 2013 | 23880127 |
| epitopes of the highly immunogenic trichomonas vaginalis α-actinin are serodiagnostic targets for both women and men. | there is a need for a point-of-care serodiagnostic test for women and men for sexually transmitted infections (stis) caused by trichomonas vaginalis. sera from women with this sti and sera from men that were analyzed in studies showing a relationship between serostatus and prostate cancer are highly seropositive in response to trichomonad α-actinin and its truncated protein (act-p2) (positive control sera). epitope mapping experiments showed that positive control sera from women had antibodies t ... | 2013 | 23616456 |
| female genital mutilation and infections: a systematic review of the clinical evidence. | female genital mutilation (fgm) is a common practice especially performed in women with no anaesthesia or antibiotics and in absence of aseptic conditions. the aim of this systematic review is to explore and analyze for first time in the current literature, the clinical evidence related to the presence of infections in the practice of fgm. | 2013 | 23315098 |
| in vitro antimicrobial activity of persian shallot (allium hirtifolium). | allium hirtifolium is a persian native plant grown in cool mountain slopes of iran. it has been used as a spice in iran for many years. according to the literature review, there are no considerable reports on the antimicrobial properties of this plant. in this study, the antimicrobial activity of persian shallot hydroalcoholic extract and f1 fraction of the plant (containing amino acid derivatives and/or other cationic compounds) was investigated on some gram positive cocci and bacilli, gram neg ... | 2012 | 23210319 |
| clinical importance of detection of bacterial vaginosis, trichomonas vaginalis, candida albicans and actinomyces in papanicolaou smears. | the aim of this study was to determine the role of papanicolaou (pap) smears in the diagnosis of lower genital tract infections. | 2012 | 23157037 |
| the action of a new antibiotic, trichomycin, upon trichomonas vaginalis, candida albicans and anaerobic bacteria. | | 1954 | 24543017 |
| high prevalence of curable sexually transmitted infections among pregnant women in a rural county hospital in kilifi, kenya. | women attending antenatal care (anc) in resource-limited countries are frequently screened for syphilis and hiv, but rarely for other sexually transmitted infections (stis). we assessed the prevalence of curable stis, defined as infection with either chlamydia trachomatis or neisseria gonorrhoeae or trichomonas vaginalis, from july to september 2015. | 2017 | 28362869 |
| high hiv prevalence and incidence among women in southern mozambique: evidence from the mdp microbicide feasibility study. | the study aimed to assess the feasibility of conducting large scale hiv prevention clinical trials in mozambique by measuring hiv prevalence and incidence among women of reproductive age. this paper describes the baseline socio-demographic characteristics of the mozambique microbicides development programme (mdp) feasibility cohort, baseline prevalence of hiv and other stis, and hiv incidence. | 2017 | 28350843 |
| routine testing of mycoplasma genitalium and trichomonas vaginalis. | mycoplasma genitalium (mg) and trichomonas vaginalis (tv) are common sexual transmitted infections (sti). however, most sti screening programmes do not include routinely detection of these pathogens. consequently, epidemiological data about mg and tv in the general population is lacking. the current study aims to give insight into the prevalence of both infections, thereby guiding decisions whether testing for these pathogens should be included routinely. | 2017 | 28301989 |
| survey of sexually transmitted disease laboratory methods in u.s. army laboratories, 2012. | sexually transmitted diseases (std) affect primarily young people (17-24 years). the u.s. military, with many young people, strives to maintain effective std treatment and prevention programs using current methods. laboratory testing technology and capacity are important for appropriate clinical management and to provide data to direct prevention programs. std laboratory capabilities are assessed in civilian and military laboratories using surveys. an army laboratory survey was conducted in 2007 ... | 2017 | 28290950 |
| point-of-care sexually transmitted infection diagnostics: proceedings of the star sexually transmitted infection-clinical trial group programmatic meeting. | the goal of the point-of-care (poc) sexually transmitted infection (sti) diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of poc sti diagnostics. experts from academia, government, nonprofit, and industry discussed poc diagnostics for stis such as chlamydia trachomatis, human papillomavirus, neisseria gonorrhoeae, trichomonas vaginalis, and treponema pallidum. key objectives included a review of current and emerging technologies, clinical an ... | 2017 | 28282646 |
| simultaneous detection and identification of sti pathogens by multiplex real-time pcr in genital tract specimens in a selected area of apulia, a region of southern italy. | genital tract infections are globally a major cause of morbidity in sexually active individuals. the aim of this study was to investigate the prevalence and associations of co-infections of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, mycoplasma hominis (mh), mycoplasma genitalium, ureaplasma urealyticum (uu) and ureaplasma parvum (up) in specimens collected from female (sf) and male (sm) patients. | 2017 | 28260146 |
| diagnosis of some genital-tract infections: part 1. an historical perspective. | making a prompt and accurate diagnosis of genital tract infections is the key to instituting appropriate treatment and the linchpin of sexually transmitted infection control. we present a brief history, not covering syphilis, of diagnostic events for each of six bacteria and one protozoan from the time of discovery up to the molecular revolution. the latter is touched upon but its impact will form the substance of a further presentation. here, hindsight is helpful in understanding the way in whi ... | 2017 | 28186463 |
| a review of expedited partner therapy for the management of sexually transmitted infections in adolescents. | adolescents are at high risk of acquiring and becoming reinfected with sexually transmitted infections. partner notification and treatment are essential to preventing the spread of sexually transmitted infections. expedited partner therapy (ept) is a method of partner treatment used by medical providers to treat patients' sexual partners without direct medical evaluation or counseling. the objective of this article is to review the current literature regarding ept effectiveness, patients' attitu ... | 2017 | 28167140 |
| partner notification and treatment for sexually transmitted infections among pregnant women in gaborone, botswana. | chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are sexually transmitted infections (stis) associated with adverse birth outcomes. untreated partners contribute to high rates of sti reinfection; thus, partner notification and treatment remain important components of sti care and control. a prospective cohort study was conducted among 300 pregnant women presenting to the antenatal clinic at princess marina hospital in gaborone, botswana who enrolled in an st ... | 2017 | 28166698 |
| impact of deploying multiple point-of-care tests with a 'sample first' approach on a sexual health clinical care pathway. a service evaluation. | to assess clinical service value of sti point-of-care test (poct) use in a 'sample first' clinical pathway (patients providing samples on arrival at clinic, before clinician consultation). specific outcomes were: patient acceptability; whether a rapid nucleic acid amplification test (naat) for chlamydia trachomatis/neisseria gonorrhoeae (ct/ng) could be used as a poct in practice; feasibility of non-naat poct implementation for trichomonas vaginalis (tv) and bacterial vaginosis (bv); impact on p ... | 2017 | 28159916 |
| chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis screening and treatment of pregnant women in port-au-prince, haiti. | in haiti, routine screening for chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) among pregnant women is not conducted; yet these sexually transmitted infections (stis) are associated with adverse birth and newborn health outcomes. we aimed to assess the acceptability and feasibility of screening and the prevalence of stis among pregnant women in port-au-prince, haiti. pregnant women of at least 18 years of age who attend haitian study group for kaposi's sar ... | 2017 | 28134005 |
| costing of national sti program implementation for the global sti control strategy for the health sector, 2016-2021. | in 2016 the world health assembly adopted the global strategy on sexually transmitted infections (sti) 2016-2021 aiming to reduce curable stis by 90% by 2030. we costed scaling-up priority interventions to coverage targets. | 2017 | 28129372 |
| an evaluation study of the becton-dickinson probetec qx (bdqx) trichomonas vaginalis trichomoniasis molecular diagnostic test in two large, urban std services. | the bashh guidelines recommend molecular tests to aid diagnosis of trichomonas vaginalis (tv) infection; however many clinics continue to use relatively insensitive techniques (ph, wet-prep microscopy (wpm) and culture). our objectives were to establish a laboratory pathway for tv testing with the becton-dickinson qx (bdqx) molecular assay, to determine tv prevalence and to identify variables associated with tv detection. | 2017 | 28108699 |
| topical tenofovir protects against vaginal simian hiv infection in macaques coinfected with chlamydia trachomatis and trichomonas vaginalis. | chlamydia trachomatis and trichomonas vaginalis, two prevalent sexually transmitted infections, are known to increase hiv risk in women and could potentially diminish preexposure prophylaxis efficacy, particularly for topical interventions that rely on local protection. we investigated in macaques whether coinfection with chlamydia trachomatis/trichomonas vaginalis reduces protection by vaginal tenofovir (tfv) gel. | 2017 | 28060011 |
| sexually transmitted diseases and infertility. | female infertility, including tubal factor infertility, is a major public health concern worldwide. most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. evidence has consistently demonstrated the effects of chlamydia trachomatis and neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor ... | 2017 | 28007229 |
| quantitative real-time polymerase chain reaction for the diagnosis of mycoplasma genitalium infection in south african men with and without symptoms of urethritis. | this study was done to diagnose mycoplasma genitalium infection based on bacterial load in urine specimens from symptomatic and asymptomatic men. | 2017 | 27898565 |
| mycoplasma genitalium and trichomonas vaginalis in france: a point prevalence study in people screened for sexually transmitted diseases. | mycoplasma genitalium and trichomonas vaginalis are common causes of sexually transmitted infections, but limited prevalence data are available in france. we aimed to evaluate the prevalence of m. genitalium and t. vaginalis infections and to assess prevalence by gender, age, sample collection sites and clinical symptoms. a multicentre collection of specimens was intended to obtain a nationwide overview of the epidemiology. | 2017 | 27836808 |
| combined testing for chlamydia, gonorrhea, and trichomonas by use of the bd max ct/gc/tv assay with genitourinary specimen types. | the bd max ct/gc/tv (max) assay is a true multiplex assay for simultaneous detection of chlamydia (ct), gonorrhea (gc), and trichomonas (tv). we evaluated assay performance for women using endocervical and vaginal swabs as well as urine specimens. a total of 1,143 women were tested for ct, gc, and tv and, subsequently, another 847 (1,990 total women) for ct and gc only, with positivity rates for ct, gc, and tv of 7.1%, 2.3%, and 13.5%, respectively. in men, the performance for ct and gc was dete ... | 2017 | 27795343 |
| budgetary impact of compliance with sti screening guidelines in persons living with hiv. | the 2015 centers for disease control sexually transmitted diseases treatment guidelines recommend annual screening of all people living with hiv (plwh) for neisseria gonorrhoeae, chlamydia trachomatis, and syphilis; annual trichomonas vaginalis screening is recommended for hiv-infected women. the study objective was to evaluate the budgetary impact of sexually transmitted infection (sti) screening. we hypothesized that recommended sti screening is costly and would not be covered in full by insur ... | 2017 | 27787348 |
| expansion of comprehensive screening of male sexually transmitted infection clinic attendees with mycoplasma genitalium and trichomonas vaginalis molecular assessment: a retrospective analysis. | of 1,493 encounters of males at a sexually transmitted infection (sti) clinic in a community with a high prevalence of sti, chlamydia trachomatis was detected in 8.7% and neisseria gonorrhoeae was detected in 6.6%. additional trichomonas vaginalis and mycoplasma genitalium screening found 17.4% and 23.9% of the encounters, respectively, to be positive for sti. sti agents were detected in 13.7% of urine specimens; addition of pharyngeal and rectal collections to the analysis resulted in detection ... | 2017 | 27629896 |
| sexually transmitted infections other than hiv/aids among women of low socio-economic class attending antenatal clinics in khartoum, sudan. | sexually transmitted infections (stis) are major health threats affecting people globally; however, the burden of stis is greatest in low-income countries. since they are physiologically more vulnerable, women are mostly affected. the risk is increased dramatically during pregnancy leading to serious health complications that may affect the newborn. underprivileged pregnant women attending antenatal clinics for routine checkups in displaced camps, a women's prison and several peripheral health c ... | 2016 | 27582306 |
| performance of self-collected penile-meatal swabs compared to clinician-collected urethral swabs for the detection of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, and mycoplasma genitalium by nucleic acid amplification assays. | men were enrolled in a study to assess the performance and acceptability of self-collected penile meatal swabs as compared to clinician-collected urethral swabs for sexually transmitted infections (stis). we expected penile-meatal swabs to perform favorably to urethral swabs for chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), and mycoplasma genitalium (mg) detection by nucleic acid amplification assays (naats). of 203 swab pairs tested; for ct, penile-meatal s ... | 2016 | 27497595 |
| evaluation of syndromic management guidelines for treatment of sexually transmitted infections in south african women. | to evaluate the performance of three different guidelines for the management of vaginal discharge syndrome (vds) for women living in a rural setting in south africa. | 2016 | 27350659 |
| prevalence of curable sexually transmitted infections in pregnant women in low- and middle-income countries from 2010 to 2015: a systematic review. | current literature comparing the prevalence rates of curable sexually transmitted infections (stis) in pregnant women in various global regions is limited. as a result, antenatal screening practices for curable stis in pregnant women, specifically treponema pallidum (syphilis), neisseria gonorrhoeae (ng), chlamydia trachomatis (ct), and trichomonas vaginalis (tv) vary around the world, differing by country and particular sti. | 2016 | 27322048 |
| prevalence and risk factors of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis and other sexually transmissible infections among women attending antenatal clinics in three provinces in papua new guinea: a cross-sectional survey. | background: papua new guinea (png) is estimated to have among the highest prevalences of hiv and sexually transmissible infections (stis) of any asia-pacific country, and one of the highest burdens of maternal syphilis globally. the prevalence of curable stis, such as chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv), among pregnant women in png is relatively unknown. methods: a cross-sectional bio-behavioural survey to investigate the epidemiology of ct, ng, ... | 2016 | 27248708 |
| chronic cervicitis: presenting features and response to therapy. | chronic nongonococcal nonchlamydial cervicitis is a condition of unknown etiology. data about treatment options are limited. our goal was to review a single center's experience in managing women with chronic ngncc. | 2016 | 27243142 |
| 2016 european guideline on the management of non-gonococcal urethritis. | we present the updated international union against sexually transmitted infections (iusti) guideline for the management of non-gonococcal urethritis in men. this guideline recommends confirmation of urethritis in symptomatic men before starting treatment. it does not recommend testing asymptomatic men for the presence of urethritis. all men with urethritis should be tested for chlamydia trachomatis and neisseria gonorrhoeae and ideally mycoplasma genitalium using a nucleic acid amplification tes ... | 2016 | 27147267 |
| detection of hpv and co-infecting pathogens in healthy italian women by multiplex real-time pcr. | several pathogens can be transmitted sexually and are an important cause of morbidity among sexually active women. the aim of the study was to detect the presence of human papillomavirus (hpv), chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), mycoplasma hominis (mh), mycoplasma genitalium (mg), ureaplasma urealyticum (uu), and ureaplasma parvum (up) in a group of 309 healthy women enrolled at the san camillo - forlanini hospital of rome by using two multiplex r ... | 2016 | 27031891 |
| ureaplasma urealyticum: presence among sexually transmitted diseases. | the aim of this study was to detect the presence of chlamydia trachomatis, neisseria gonorrhoeae, mycoplasma genitalium, mycoplasma hominis, trichomonas vaginalis, and ureaplasma urealyticum in genital specimens of symptomatic patients. this study also examined the role of u. urealyticum in infections of the lower genital tract. cervical and urethral samples from 96 patients (46 males, 50 females) were tested using the seeplex((®)) std6 ace kit. consent forms were received and a questionnaire wa ... | 2017 | 27000449 |
| pelvic examination at the 6-week postpartum visit after cesarean birth. | the objective of this study was to assess the utility of the pelvic examination at the 6-week postpartum visit after cesarean birth. | 2016 | 26971582 |
| alterations in the genital microbiota in women with spinal cord injury. | to evaluate the vaginal and cervical microbiota in women with spinal cord injury compared with mobile women. | 2016 | 26942354 |
| male non-gonococcal urethritis: from microbiological etiologies to demographic and clinical features. | to detect microorganisms responsible for male acute urethritis and to define the microbiology of non-gonococcal urethritis. | 2016 | 26845624 |
| vijana vijiweni ii: a cluster-randomized trial to evaluate the efficacy of a microfinance and peer health leadership intervention for hiv and intimate partner violence prevention among social networks of young men in dar es salaam. | intimate partner violence (ipv) and sexually transmitted infections (stis), including hiv, remain important public health problems with devastating health effects for men and women in sub-saharan africa. there have been calls to engage men in prevention efforts, however, we lack effective approaches to reach and engage them. social network approaches have demonstrated effective and sustained outcomes on changing risk behaviors in the u.s. our team has identified and engaged naturally occurring s ... | 2016 | 26842360 |
| prevalence of mycoplasma genitalium in men with urethritis and in high risk asymptomatic males in tel aviv: a prospective study. | we sought to investigate the prevalence of mycoplasma genitalium, chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis in men presenting to a sexually transmitted infection (sti) clinic, with special attention to m. genitalium, its occurrence in israeli patients, coinfections, and risk factors. in a cross-sectional study, 259 men were successively enrolled in the tel aviv levinsky clinic for stis between november 2008 and november 2010. there were 118 men with urethritis and 1 ... | 2017 | 26826161 |
| cervicitis: a prospective observational study of empiric azithromycin treatment in women with cervicitis and non-specific cervicitis. | treatment with 1 g azithromycin was observed prospectively in 130 women with cervicitis (>30 polymorphonuclear leucocytes/high-powered field) enrolled in a cervicitis aetiology study of 558 women at three sexually transmitted infection clinics in sydney, australia. two overlapping groups of women with cervicitis were considered: 'cervicitis group 1' (n = 116) excluded women with trichomonas vaginalis and a subgroup of this, 'cervicitis group 2' (non-specific cervicitis) (n = 96) further excluded ... | 2017 | 26792283 |
| 2nd bashh oxford diagnostics course, november 2015. | the second british association for sexual health and hiv oxford diagnostics course of 2015 focussed on recent challenges and emerging concepts within diagnostics and service design. in response to increasing sexually transmitted infection rates and subsequent demand on uk sexual health services, multiple approaches to improving patient flow and reducing waiting times were presented. the value of novel remote sexually transmitted infection testing was explored, with a description of the patient j ... | 2016 | 26787639 |
| combination emtricitabine and tenofovir disoproxil fumarate prevents vaginal simian/human immunodeficiency virus infection in macaques harboring chlamydia trachomatis and trichomonas vaginalis. | genital inflammation associated with sexually transmitted infections increases susceptibility to human immunodeficiency virus (hiv), but it is unclear whether the increased risk can reduce the efficacy of pre-exposure prophylaxis (prep). we investigated whether coinfection of macaques with chlamydia trachomatis and trichomonas vaginalis decreases the prophylactic efficacy of oral emtricitabine (ftc)/tenofovir disoproxil fumarate (tdf). macaques were exposed to simian/human immunodeficiency virus ... | 2016 | 26743846 |
| analytical performance of multiplex real-time pcr for six sexually transmitted pathogens. | most organisms that cause sexual transmitted diseases (stds) are fastidious pathogens that are difficult to detect with conventional microbiological methods and the proportions of multiple infections were noted up to 39.3% among the sti-positive subjects. however, only a few multiplex pcr and multiplex real-time pcr tests that can screen more than six microorganisms that cause stds have been assessed. | 2015 | 26732001 |
| usefulness of a novel multiplex real-time pcr assay for the diagnosis of sexually-transmitted infections. | sexually transmitted infections (sti) are currently on the increase worldwide. new molecular tools have been developed in the past few years in order to improve their diagnosis. an evaluation was carried out using a new commercially available real-time pcr assay, anyplex™ ii sti-7 (seegene, seoul, korea), which detects seven major pathogens in a single reaction - chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, mycoplasma hominis, mycoplasma genitalium, ureaplasma urealyticum ... | 2016 | 26706392 |
| prevalence of chlamydia trachomatis, trichomonas vaginalis and neisseria gonorrhoeae based on data collected by a network of clinical microbiology laboratories, in italy. | bacterial and protozoal sexually transmitted infections (stis), such as chlamydia trachomatis, trichomonas vaginalis and neisseria gonorrhoeae, may cause acute symptoms, chronic infections and severe long-term complications. the complications of these infections in women include pelvic inflammatory disease, chronic pelvic pain, tubal infertility, ectopic pregnancy, and infertility. moreover, infection during pregnancy is associated with premature rupture of the membranes, low birth weight and mi ... | 2016 | 26691509 |
| urethritis-associated pathogens in urine from men with non-gonococcal urethritis: a case-control study. | the aetiology of non-gonococcal urethritis (ngu) remains unexplained in 30-40% of patients. urine samples from men attending swedish sexually transmitted disease clinics were examined by species-specific quantitative pcrs for chlamydia trachomatis, mycoplasma genitalium, trichomonas vaginalis, ureaplasma urealyticum, u. parvum, adenovirus, herpes simplex virus, neisseria meningitidis, haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae. a total of 187 men with acute ngu (s ... | 2016 | 26658669 |
| sexually transmitted infections in children as a marker of child sexual abuse and direction of future research. | this review considers recent evidence on sexually transmitted infections (stis) as a marker of child sexual abuse (csa), when diagnosed after the neonatal period. it also aims to identify if there are specific areas where additional research is required. | 2016 | 26658657 |
| the prevalence of causative organisms of community-acquired urethritis in an age group at high risk for sexually transmitted infections in korean soldiers. | this study was designed to evaluate the causative organisms in young male soldiers with clinical signs and symptoms after sexual contact that suggests a diagnosis of urethritis. | 2017 | 26607860 |
| sexual assault and sexually transmitted infections in adults, adolescents, and children. | survivors of sexual assault are at risk for acquiring sexually transmitted infections (stis). we conducted literature reviews and invited experts to assist in updating the sexual assault section for the 2015 centers for disease control and prevention sexually transmitted diseases (std) treatment guidelines. new recommendations for sti management among adult and adolescent sexual assault survivors include use of nucleic acid amplification tests (naats) for detection of trichomonas vaginalis by va ... | 2015 | 26602623 |
| advances in the understanding and treatment of male urethritis. | neisseria gonorrhoeae and chlamydia trachomatis are well-documented urethral pathogens, and the literature supporting mycoplasma genitalium as an etiology of urethritis is growing. trichomonas vaginalis and viral pathogens (herpes simplex virus types 1 and 2 and adenovirus) can cause urethritis, particularly in specific subpopulations. new data are emerging regarding the potential role of bacterial vaginosis-associated bacteria in urethritis, although results are inconsistent regarding the patho ... | 2015 | 26602615 |
| cervicitis aetiology and case definition: a study in australian women attending sexually transmitted infection clinics. | studies examining cervicitis aetiology and prevalence lack comparability due to varying criteria for cervicitis. we aimed to outline cervicitis associations and suggest a best case definition. | 2016 | 26586777 |
| pelvic inflammatory disease associated with chlamydia trachomatis but not mycoplasma genitalium in new zealand. | background there is a paucity of studies looking at associations between mycoplasma genitalium and pelvic inflammatory disease (pid). the objectives of this study were to estimate the prevalence of m. genitalium in women attending a sexual health service in new zealand and secondly to examine for an association of m. genitalium with pid. | 2016 | 26547264 |
| prevalent bacterial vaginosis infection - a risk factor for incident sexually transmitted infections in women in durban, south africa. | the association between bacterial vaginosis (bv) and incident sexually transmitted infections (stis) in a cohort of high-risk women from durban, south africa was investigated in this study. we undertook a secondary analysis of the methods for improving reproductive health in africa trial that assessed effectiveness of the latex diaphragm and lubricant gel on hiv prevention among women. during study visits, urine specimens were collected for testing for neisseria gonorrhoeae, chlamydia trachomati ... | 2016 | 26538552 |
| multiplex pcr testing for nine different sexually transmitted infections. | current sexually transmitted infection (sti) testing is not optimal due to delays in reporting or missed diagnoses due to a lack of comprehensive testing. the filmarray® (biofire diagnostics, llc, salt lake city, utah) is a user-friendly, fully automated, multiplex pcr system that is being developed for rapid point-of-care use. a research-use-only sti panel including multiple pcr primer sets for each organism was designed to detect chlamydia trachomatis, neisseria gonorrhoeae, treponema pallidum ... | 2016 | 26538551 |
| a scottish multi-centre service evaluation examining the prevalence and diagnosis of trichomonas vaginalis in symptomatic women attending sexual health clinics. | trichomoniasis caused by the protozoan parasite trichomonas vaginalis (tv) is one of the most commonly occurring sexually transmitted infections of non-viral origin. this study examines the prevalence of tv infection amongst consenting symptomatic women attending three of the largest sexual health clinics in scotland, united kingdom. in addition, an evaluation of three testing methods to identify tv from vaginal fluid was performed involving the commercial hologic aptima tv transcription-mediate ... | 2016 | 26429895 |
| comparison of cervico-vaginal colonization among sexually active women by intrauterine device use. | in this study we aimed to evaluate the effect of intrauterine devices (iuds) on cervico-vaginal colonization. | 2015 | 26409733 |
| evaluation of the new amplisens multiplex real-time pcr assay for simultaneous detection of neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma genitalium, and trichomonas vaginalis. | in this study, we performed an evaluation of the new ce-marked multiplex real-time amplisens n.gonorrhoeae/c.trachomatis/m.genitalium/t.vaginalis-multiprime-frt pcr assay compared to aptima tests, i.e., aptima combo 2 assay, aptima trichomonas vaginalis assay (fda-approved), and two different aptima mycoplasma genitalium assays (research use only; one of them only used for discrepancy analysis). vaginal swabs (n = 209) and first-void urine (fvu) specimens from females (n = 498) and males (n = 55 ... | 2015 | 26299582 |
| prevalence of vulvovaginitis and relation to physical findings in girls assessed for suspected child sexual abuse. | the presence of sexually transmitted infections (stis) in patients with suspected sexual abuse is uncommon in the field of pediatrics. | 2015 | 26294142 |
| trichomonas vaginalis and mycoplasma genitalium: age-specific prevalence and disease burden in men attending a sexually transmitted infections clinic in amsterdam, the netherlands. | men are not routinely tested for trichomonas vaginalis (tv) and mycoplasma genitalium (mg) in the netherlands and, therefore, very few studies have looked into their prevalence and/or role in urogenital complaints in the dutch male population. | 2016 | 26283740 |
| distribution of human papillomavirus (hpv) genotypes and bacterial vaginosis presence in cervical samples from paraguayan indigenous. | to determine the frequency of human papillomavirus (hpv) types and to assess bacterial vaginosis (bv) possible associations with cervical infections in indigenous paraguayan women of the department of presidente hayes. | 2015 | 26283550 |
| prevalence of microorganisms co-infections in human papillomaviruses infected women in northern china. | due to scarce data on the prevalence of genital microorganism infections among individuals with human papillomavirus (hpv) infections, the present study aimed to evaluate microorganism co-infections and associated risk factors in hpv-infected women in northern china. | 2016 | 26280325 |
| large two-centre study into the prevalence of mycoplasma genitalium and trichomonas vaginalis in the netherlands. | mycoplasma genitalium and trichomonas vaginalis are common sexually transmitted infections (stis). in the netherlands, testing for m. genitalium and t. vaginalis is not recommended for first-line sti screening. recent reports about the increasing antimicrobial resistance in m. genitalium raise concern about the adequacy of current empirical treatment regimens. it is necessary to have insight in the prevalence of m. genitalium and t. vaginalis in order to evaluate current first-line sti screening ... | 2016 | 26199286 |
| human papillomavirus positivity in women undergoing intrauterine insemination has a negative effect on pregnancy rates. | sexually transmitted infections are a major cause of infertility. human papillomavirus (hpv) infection is one of the most common viral infections of the female genital tract. only a limited number of studies have investigated the influence of hpv on fertility and its impact remains controversial. | 2016 | 26160018 |
| diagnosis and treatment of bacterial prostatitis. | prostate inflammation is a common syndrome, especially in men under 50. it usually presents with voiding symptoms and pain in the genitourinary area, and sometimes as sexual dysfunction. based on clinical and laboratory characteristics, prostatitis is classified as acute bacterial prostatitis, chronic bacterial prostatitis, chronic inflammatory and non-inflammatory prostatitis or chronic pelvic pain syndrome, and asymptomatic inflammatory prostatitis. bacterial prostatitis is most often caused b ... | 2015 | 26086164 |
| the role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in nairobi, kenya. | little is known about risk factors for persistent high-risk human papillomavirus (hrhpv) infection in low-income settings, and prior research has not quantified the relative duration of hrhpv infections stratified by risk factors. we compared the duration of hrhpv infection among female sex workers (fsws) by exposure to sexually transmitted infections (stis), using a highly sensitive biomarker assay. | 2015 | 25970306 |
| prevalence and correlates of trichomonas vaginalis infection among female sex workers in a city in yunnan province, china. | sexual transmission is the fastest growing route of hiv transmission in china, and trichomonas vaginalis(tv) can facilitate hiv transmission and acquisition. our goal was to determine the prevalence and correlates of tv infection among female sex workers (fsws). this cross-sectional study was conducted in a city of yunnan province in southern china, with confidential face-to-face interviews and laboratory tests for tv (wet mount) and other sexually transmitted infections. a total of 734 fsws par ... | 2016 | 25957327 |
| detection of mycoplasma genitalium from male primary urine specimens: an epidemiologic dichotomy with trichomonas vaginalis. | a total of 2750 male urines subjected to a transcription-mediated amplification (tma)-based mycoplasma genitalium assay yielded 188 positive results (6.84%). this rate was similar to chlamydia trachomatis (6.87%; p = 0.96) and greater than neisseria gonorrhoeae (4.0%) and trichomonas vaginalis (2.3%; p < 0.0002). mean age of m. genitalium-infected males (30.8) was similar to n. gonorrhoeae (p = 0.78) but less than t. vaginalis (mean, 41.6; p < 0.0001). a total of 266 sti clinic encounters had at ... | 2015 | 25934156 |
| comparison of substance use typologies as predictors of sexual risk outcomes in african american adolescent females. | african american female adolescents have a disproportionate risk of sexually transmitted infections (stis) and other adverse sexual health outcomes. both alcohol and marijuana use have been shown to predict sexual risk among young african american women. however, no studies have attempted to differentiate alcohol and marijuana typologies use as predictors of sexual risk outcomes exclusively among adolescents who use these substances. this study compared recent alcohol and/or marijuana use as pre ... | 2016 | 25929200 |
| prevalence and factors associated with sexually transmitted infections among hiv positive women opting for intrauterine contraception. | women living with hiv/aids (wlha) are a high risk group for sexually transmitted infections (stis). however, the majority of women with stis are asymptomatic. data on prevalence of stis among wlha in uganda are limited. the objective of the study was to determine prevalence and factors associated with stis among wlha opting for intrauterine contraceptive device (iud). | 2015 | 25859659 |
| opportunities and pitfalls of molecular testing for detecting sexually transmitted pathogens. | in the last 20 years, nucleic acid amplification tests (naats) have gradually replaced traditional methods for the detection of sexually transmitted infections. naat technology comes with some considerable benefits for diagnosis, including increased sensitivity, rapid result turnaround and suitability for high throughput screening of asymptomatic individuals using more-readily available specimens. however, the transition to naat has not come without its problems. false-negative and false-positiv ... | 2015 | 25714587 |
| trichomonas vaginalis infection: how significant is it in men presenting with recurrent or persistent symptoms of urethritis? | persistent or recurrent non-gonococcal urethritis has been reported to affect up to 10-20% of men attending sexual health clinics. an audit was undertaken to review the management of persistent or recurrent non-gonococcal urethritis in men presenting at whittall street clinic, birmingham, uk. detection of trichomonas vaginalis infection was with the newly-introduced nucleic acid amplification test. a total of 43 (8%) of 533 men treated for urethritis re-attended within three months with persiste ... | 2016 | 25663246 |
| a mixed methods approach to assess the likelihood of testing for sti using self-collected samples among behaviourally bisexual women. | behaviourally bisexual women (women who have sex with women and men (wswm)) are more likely to report a history of sexually transmitted infections (sti) than women who have sex exclusively with men or exclusively with women. barriers to care may prohibit wswm from seeking sti testing. the present study investigated participant willingness to self-collect oral, vaginal and anal samples for sti testing. | 2015 | 25637328 |
| a multiplex pcr assay for the simultaneous detection of chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis. | for developing countries, sexually transmitted infections (stis) and their complications are ranked in the top 5 disease categories for which adults seek medical treatment. chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are the three most common stis worldwide, with tv accounting for over half of the cases. in developing countries, traditional methods for diagnosing stis are laborious, often not very sensitive, and have a long turnaround time with most rec ... | 2015 | 25595915 |
| etiology and antimicrobial susceptibility of pathogens responsible for urethral discharge among men in harare, zimbabwe. | periodic etiological surveillance of sexually transmitted infection (sti) syndromes is required to validate treatment algorithms used to control stis. however, such surveys have not been performed in zimbabwe over the past decade. | 2014 | 25581806 |