| anti-hbc titer in relation to the etiological role of hepatitis b virus in primary hepatocellular carcinoma. | the antibody to hepatitis b core antigen (anti-hbc) is belived to be a marker for natural infection with hepatitis b virus (hbv). in order to study the etiological role of hbv in relation to primary hepatocellular carcinoma (phc), the anti-hbc in sera of 31 phc patients was surveyed by the immune adherence hemagglutination method which was about 10 times more sensitive than the complement fixation method. twenty two out of 31 phc cases were positive for anti-hbc (71.0%). the is a higher rate of ... | 1977 | 192028 |
| serologic markers of hepatitis a and b in chronic active hepatitis. | sera from 44 patients with a well-documented diagnosis of chronic active hepatitis (cah) were analysed for antibodies to hepatitis a virus (anti-hav), hepatitis b surface antigen (hbsag) and anti-hbs, e-antigen (hbeag) and anti-hbe, as well as antibodies to hepatitis b core antigen (anti-hbc). twenty-two patients had serologic evidence of hepatitis a infection. the frequency of anti-hav was low in patients under 50 years of age (21%) but high among older patients (72%). there was, however, no si ... | 1978 | 212821 |
| the growth of knowledge about a disease: hepatitis. | | 1979 | 224700 |
| hepatitis b virus infection and primary hepatocellular carcinoma. | ninety-three patients with biopsy-proven primary hepatocellular carcinoma (phc) from uganda, zambia, and the united states were examined for serologic evidence of hepatitis b virus (hbv) infection. patients were tested for hepatitis b surface antigen (hbsag) and its antibody (anti-hbs), antibody to the hepatitis b core antigen (anti-hbc), hepatitis b e antigen (hbeag), and its antibody (anti-hbe). active hbv infection, as indicated by positive tests for hbsag (with or without anti-hbs) and anti- ... | 1977 | 192895 |
| a solid-phase radioimmunoassay for detection of igm antibodies to hepatitis a virus. | the conditions for a sensitive and specific solid-phase radioimmunoassay (ria) for the detection of igm antibodies to hepatitis a virus (hav) were optimized, and the ria was used to assay sera from patients with hepatitis. igm antibodies to hav reached highest concentrations between one and three weeks after onset of icterus and were measurable in follow-up sera for at least 12 months after infection. to prove the specificity, the igg antibodies were separated from patient sera by sucrose densit ... | 1979 | 225390 |
| [discovery of hepatitis virus]. | | 1979 | 225395 |
| [hbs ag-positive hepatocellular cancer (pathomorphologic study)]. | pathomophological and histochemical analysis of 7 autopsy cases of primary hepatocellular carcinoma was performed. direct immunofluorescence with an anti-hbsag serum and staining with orsein according to shikata's method revealed the presence of hbsag in hepatocytes of the cirrhotic tissue and in tumour cells. cirrhotic nodes were found to have numerous hbsag-positive cells, whereas in the tumour tissue the number of such cells was insignificant and they were found only in highly differentiated ... | 1979 | 226040 |
| hbsag-negative chronic active hepatitis related to hepatitis b virus. | numerous cases of chronic hepatitis have been shown to be closely associated with persistent infection with hepatitis b virus (hbv). a group of 100 patients suffering from chronic active hepatitis (cah) was investigated for hbv serologic markers. of these, 35 patients were hbsag-positive; in 26 hbsag-negative subjects, anti-hbc were detected using counterimmune electrophoresis and complement-fixation tests. these data suggest that chronic liver disease in patients who were only anti-hbc-positive ... | 1978 | 214684 |
| line cell saga - an argument in favor of production of biologics in cancer cells. | | 1979 | 227236 |
| viral vaccines under development: a third generation. | in summary then, my purpose has been two-fold: on the one hand, i have tried to highlight the kinds of basic science advances in both cellular and virologic research that can (and should) be focussed both on vaccines under development and, retrospectively, on those whose origins were strictly empiric. on the other hand, i have attempted a partial survey of some of the prominent members of a potential new generation of vaccines to point out areas where these advances can and should contribute eit ... | 1979 | 227237 |
| acute viral hepatitis: modern knowledge. | | 1977 | 193084 |
| evidence for clustering of hepatitis b virus infection in families of patients with primary hepatocellular carcinoma. | family member of 13 patients with hepatitis b surface antigen (hbsag) positive primary hepatocellular carcinoma (phc) were tested for the presence of hepatitis b virus-associated antigens and antibodies. of the 122 members examined, circulating hgsag was detected in 47 (39%), antibody to hbsag (anti-hbs) was found in 37 (30%), and antibody to hepatitis b core antigen (anti-hbc) alone was present in 13 (11%). the relatives with the highest frequency of hbsag positivity were the offspring of the p ... | 1979 | 228843 |
| recent advances in the identification of hepatitis viruses. | resulting directly from the discovery of virus-related antigens, rapid progress has marked the last decade of viral hepatitis research. the hepatitis b virion has been tentatively identified as a dna virus with an endogenous dna polymerase, and new serological markers for type b hepatitis have been discovered. hepatitis a antigen has been identified on a virus-like particle thought to be the hepatitis a virion. progressively more sophisticated assays for hepatitis antigens and antibodies have be ... | 1977 | 196274 |
| [core and coat of the hepatitis b-virus and cytoplasmic viruslike particles in chronic hepatitis. an electron microscopic study (author's transl)]. | in the second liver biopsy material of a seropositive patient receiving immunosuppressive therapy (corticosteroid + imuran) for chronic active hepatitis (cah), intranuclear, ring-shaped, 20--25 nm in diameter non-coated particles (core) of liver cells and intracisternal filaments, 23 nm in diameter (coat) of the soft er in the "ground-glass" hepatocytes were demonstrated by electron microscopy. core-particles in the cytoplasm were seen occasionally. dane-particles could not be visualized. cytopl ... | 1977 | 200036 |
| [retrospective study of 149 cases of hepatitis b virus infections. study of markers and of evolution]. | a retrospective study has been performed in 149 subjects with present or past hbs antigenemia. the group consisted of 8 asymptomatic carriers, 90 with acute hepatitis, 7 with fulminating hepatitis, 27 with chronic hepatitis, 16 with cirrhosis and 1 with hepatoma. the changes from one clinical condition to another, the sources of infection, the percentage of acute hepatitis in the history of chronic hepatitis cases and the working capacity an average of two years after the infection were studied. ... | 1979 | 229549 |
| hepatocellular carcinoma and chronic persistent hepatitis. | the morphologic type of cirrhosis that is followed most frequently by hepatocellular carcinoma is posthepatitic cirrhosis. furthermore, hb ag is detected in a high rate among cases with hepatocellular carcinoma suggesting the intimate causal relationship between hepatitis b virus and hepatocellular carcinoma. it has been considered that hepatocellular carcinoma might develop during destruction and regeneration of fully developed liver cirrhosis. however, hepatocellular carcinoma is combined with ... | 1977 | 200057 |
| biophysical and biochemical properties of cr326 human hepatitis a virus. | cr326 human hepatitis a virus purified by isopycnic banding from infected marmoset sera was shown to consist of 27 mmu spherical particles on electron microscopic examination. the particles were identified as hepatitis a virus by tests by infectivity and by specific neutralization of infectivity with convalescent human hepatitis a serum. also, identical 27 mmu viruses in liver extracts gave specific reactions with hepatitis a antisera when tested by immune electron microscopy. the buoyant densit ... | 1975 | 171955 |
| epstein-barr virus infection in polytransfused patients with homozygous beta-thalassaemia. | the frequency of epstein-barr virus (ebv) and hepatitis b virus (hbv) infection has been studied in 149 polytransfused thalassaemic patients and in healthy controls. evidence for ebv infection was based on the detection of antibodies to viral capsid antigen (anti-vca) and for hbv infection on the detection of either hepatitis b surface antigen (hbsag) or hepatitis b surface antibody (anti-hbs). the frequency of anti-vca was not significantly higher in the patients (16.4%) compared to the control ... | 1979 | 230639 |
| viral hepatitis: clinical aspects. | in the majority of instances acute viral hepatitis resolves totally without sequelae. fulminant hepatitis is a highly lethal lesion but 20 to 25 per cent of patients, principally young patients, survive. survivors do not appear to develop chronic liver disease. persistent viral hepatitis follows acute icteric hepatitis, both type b and non-b, in 10 to 12 per cent of patients. six long-term hbs ag carriers demonstrated hbs ag clearance after 14-73 months. chronic active viral hepatitis often prog ... | 1975 | 171956 |
| the effect of sodium thiocyanate on virus structure. | a study of two different virus types after elution from immunosorbent columns by sodium thiocyanate has shown that virus degradation occurs. the two virus types studied were hepatitis b and rotavirus. hepatitis b antigen (hbag) was only slowly degraded and retained many of its morphological features, although in an altered form; rotavirus was highly sensitive to the chaotropic agent, losing both its viability and its morphological integrity. during the process of disassembly a previously undetec ... | 1979 | 232143 |
| the transmission and outcome of hepatitis a, b, and non-a, non-b: a review. | | 1979 | 232876 |
| controlled synthesis of hbsag in a differentiated human liver carcinoma-derived cell line. | a significant aspect of primary hepatic carcinoma in man is the high positive correlation of hepatocellular carcinoma with infection with hepatitis b virus (hbv)1. analysis of the relationship between hbv infection and oncogenesis is difficult because natural infection with hbv is limited to man and experimental infection has been achieved only in chimpanzees and gibbons. furthermore, because hbv has not been successfully propagated in cell culture, basic study of virus-cell interaction of the a ... | 1979 | 233137 |
| [chronic hepatitis. etiopathogenesis]. | | 1979 | 233221 |
| [the relation of infection with the hepatitis b-agent to primary hepatic carcinoma (author's transl)]. | in asia, africa and other tropical areas primary hepatic carcinoma (phc) is associated with liver cirrhosis of the post-necrotic (macronodular) type. chronic viral hepatitis is likely to be the cause of this cirrhosis in many patients from regions where chronic infection with the hepatitis b virus (hbv) is common. more than 95% of patients with hepatoma (in mali and senegal) have evidence of infection with hbv, a much higher frequency than in controls. thirty-nine of 62 phc patients had hepatiti ... | 1976 | 190499 |
| [hepatitis b virus surface antigen (hbsag) in human hepatocellular carcinoma and its surrounding tissues of liver (author's transl)]. | | 1979 | 233358 |
| acute viral hepatitis. | it is now possible to define two forms of acute viral hepatitis by means of specific serological tests and at least one other form by exclusion. these diseases are known as hepatitis a, hepatitis b and non a non b hepatitis respectively. major features of the virology, pathogenesis, laboratory diagnosis, epidemiology, mode of spread and control of each disease are briefly reviewed. | 1978 | 208497 |
| a seroepidemiologic study of infection with hav and hbv in five pacific islands. | a batch of 1025 serum samples, obtained from healthy subjects and hospital patients from five pacific islands (viti levu, funafuti, niue, rarotonga and upolu) were tested for antibody to hepatitis a virus (anti-hav), hepatitis b surface antigen (hbsag) and antibody to hepatitis b surface antigen (anti-hbs) by solid phase radioimmunoassay (spria). high frequencies of anti-hav were observed in each population (funafuti, 79.9%; upolu, 81.6%; viti levu, 84.3%; rarotonga, 95.0%; and niue, 95.2%), and ... | 1979 | 224697 |
| etiology of liver disease in renal-transplant patients. | the etiology of 72 episodes of liver disease that developed in 62 of 162 renal-transplant recipients was evaluated. infection with hepatitis b virus was a minor problem, and none of our patients had evidence of infection with hepatitis a. cytomegalovirus infection was ubiquitous in the population and probably accounted for many episodes of acute liver disease. this agent's role in causing chronic hepatitis is less secure. infections with other viruses including epstein-barr virus, adenovirus, an ... | 1979 | 224742 |
| serologic markers of hepatitis a and b in acute and chronic liver disease. | | 1979 | 226813 |
| extrahepatic manifestations of viral hepatitis. | recent evidence indicates that viral hepatitis is sometimes associated with the production of extrahepatic tissue injury. hepatitis b virus (hbv) infection is most commonly incriminated but non-type b hepatitis may also be involved. three types of syndromes have been recognized. first, a serum sickness-like prodrome consisting of skin eruptions, urticaria and polyarthralgias or arthritis may occur from one to six weeks prior to the onset of hepatitis in 15 to 20 per cent of patients and usually ... | 1975 | 242219 |
| [transmission of hepatitis b virus from the mother to the infant]. | | 1977 | 243551 |
| emerging patterns of hepatitis b chronic liver disease in australia. | until now, the hepatitis b virus has been thought to play a minor role in the aetiology of chronic liver disease in australia. this is a report of 21 patients with cirrhosis and/or primary hepatocellular carcinoma with hepatitis b antigenaemia. primary hepatocellular carcinoma occurred in six patients, five of whom had underlying cirrhosis. the disease occurred mainly in non-australian born males, and was not often associated with a previous history of hepatitis. the death of 16 patients within ... | 1979 | 228647 |
| [prevention and therapy of viral hepatitis]. | | 1979 | 253774 |
| [prognosis of viral hepatitis]. | | 1979 | 253775 |
| messenger rna hybridized with the dna isolated from hepatitis b dane particles. | | 1979 | 261965 |
| prevalence of antibody to hepatitits b surface antigen among staff in an edinburgh hospital. | antibody to hepatitis b surface antigen was detected by radioimmunoprecipitation in 74 (5-5%) of 1336 staff members in a large general hospital in edinburgh, in 14 (2-9%) of 480 volunteer blood donors in the area, and in 12 (6-1%) of 197 pregnant women attending for the first time at the ante-natal clinic in the hospital. rates of antibody prevalence rose with age in the sample of hospital staff and in that of the blood donors, particularly among males. on the other hand, in the ante-natal patie ... | 1977 | 264499 |
| pathology and pathogenesis of viral hepatitis. | | 1978 | 214873 |
| [the dentist's responsibility in the oral rehabilitation of patients with chronic kidney diseases]. | it is important that the dentist knows about disturbances of blood coagulation during and after hemo-dialysis, so that he avoids administration of platelet-inhibiting medication like aspirin and that he recognizes radiologically visible signs of insufficient dialysis in the jaws. because of the reduced protection from infections, antibiotic prophylaxis should be carried out before every dental operation, the medication of choice being penicillin. due to the high rate of infection by the hepatiti ... | 1977 | 265241 |
| partial amino acid sequence of two major component polypeptides of hepatitis b surface antigen. | determination of the amino acid sequence of the immunogenic polypeptides of hepatitis b surface antigen may not only permit molecular localization of the distinct determinants a, d, and y but may also lead to the synthesis of a hapten useful in prophylactic immunization against hepatitis b virus infection. for this purpose, purified monotypic hepatitis b surface antigen of adw subtype was resolved into equal amounts of two major polypeptides (22,000 and 28,000 daltons) and up to six other minor ... | 1977 | 266193 |
| host specificity of a serum marker for hepatitis b: evidence that "e antigen" has the properties of an immunoglobulin. | a family of antigens, referred to collectively as e antigen (eag), has been detected in sera of some individuals with liver disease who test positive for hepatitis b surface antigen. studies on eag partially purified by affinity chromatography on insolubilized antibodies to eag revealed the following: (i) eag has the physicochemical and immunologic properties of an immunoglobulin, predominantly of the igg4 subclass, and (ii) specific antigenic sites, designated as e determinants, differentiate e ... | 1977 | 266209 |
| developments in viral hepatitis. | viral hepatitis is a major public health problem occurring endemically in all parts of the world. the general term viral hepatitis refers to infections caused by hepatitis virus type a, type b and a more recently identified infection referred to as "non-a: non-b" hepatitis. these clinically and pathologically similar forms of hepatitis have been studied intensively following the discovery of a specific antigen, australia antigen, one of the markers of infection with hepatitis b virus. | 1978 | 215717 |
| comparative immunology of hepatitis a and b. | | 1979 | 218418 |
| an appraisal of the relationship between primary hepatocellular carcinoma and hepatitis b virus. | the association between hepatitis b virus infection and primary hepatocellular carcinoma is reviewed. on the basis of serological and tissue examination there is a close link between virus infection and the tumour. while there is evidence to favour an oncogenic role for virus this is not conclusive, and other possible explanations for the relationship are discussed. | 1979 | 229071 |
| a comparative study of hepatitis b viral markers in the family members of asian and non-asian patients with hepatitis b surface antigen-positive hepatocellular carcinoma and with chronic hepatitis b infection. | serologic tests for evidence of hepatitis b virus (hbv) infection were performed on family members of asian and non-asian patients with either hepatitis b surface antigen (hbsag)-positive hepatocellular carcinoma or chronic hbv infection. asian family members had a significant increase of hbsag (34% higher) and of antibody to hbsag or of antibody to hepatitis b core antigen (50% higher) when they were compared with non-asian family members. in the asian group, viral markers were detected more fr ... | 1979 | 229173 |
| the virus of hepatitis b a new dimension in the diagnosis of sexually transmitted disease. | ten patients presenting with venereal or dermatological disorders have been found to have evidence of infection with the virus of hepatitis b; only five had distinguishable liver dysfunction, yet all had either detectable antigen or antibody. antigen subtype ayw has been identified in four of these people. once rare in the local population, hepatitis b virus infection appears to be increasing in incidence with cases attributable to inoculation and to direct contact, as well as presenting as a co ... | 1978 | 273792 |
| duality of hepatitis b e antigen in serum of persons infected with hepatitis b virus: evidence for the nonidentity of e antigen with immunoglobulins. | hepatitis b e antigen (hbeag) is detected in the serum of some persons infected with hepatitis b virus. owing to a close correlation of hbeag and hepatitis b virus in the serum, it has been used as a practical indicator of infectivity. two entities of hbeag activity physicochemically different from each other were demonstrated in the serum of persons infected with hepatitis b virus. one was associated with a molecule that precipitated in 1.33 m ammonium sulfate solution, was larger than igg, and ... | 1978 | 273922 |
| cytoplasmic hepatitis b surface antigen and the ground-glass appearance in hepatocellular carcinoma. | hepatitis b surface antigen (hbsag) was identified with aldehyde fuchsin and immunoperoxidase stain and by immunofluorescence in malignant hepatocytes with a ground-glass appearance in only one needle biopsy specimen of a series of biopsies from 130 consecutive cases of hepatocellular carcinoma. the patient was 14 years old. hbsag was identified by aldehyde fuchsin stain in nonmalignant hepatocytes of 48 (58%) of 83 biopsy specimens that contained nonmalignant liver tissue. the antigen was demon ... | 1979 | 218445 |
| [hepato-cellular carcinoma associated with hbs antigen: a study of 25 cases from vietnam (author's transl)]. | using orcein staining and indirect immunofluorescence on paraffin sections, the authors demonstrated hbs ag in 64% of 25 hepatocellular carcinomas (including "bone metastasis") in vietnam. the main findings in the literature suggesting a causal role for hepatitis b virus in primary liver cancer are discussed. | 1978 | 219448 |
| the dental practitioner and systemic infections of oral origin. | | 1978 | 279514 |
| [new data on the epidemiology of viral hepatitis (literature review)]. | | 1979 | 229643 |
| a seroepidemiologic study of hepatitis b virus infection in taiwan. | | 1978 | 284101 |
| viral exposure and abnormal liver function in haemophilia. | several studies have recently documented the presence of persistently abnormal liver function tests in asymptomatic haemophiliacs. while the aetiology is unknown it is possible that repeated exposure to agents transmitted in blood products may be important. this study has attempted to determine the prevalence of viral exposure and its relationship to liver function in this multitransfused group of individuals. the prevalence of viral antibodies with the exception of antibody to hepatitis b surfa ... | 1979 | 221550 |
| hepatitis b virus infection in dental students. a two-year evaluation. | | 1979 | 289728 |
| studies of donors who transmit posttransfusion hepatitis. | sera and questionnaires were evaluated retrospectively from 128 volunteer blood donors whose blood had been implicated in cases of clinically recognized post-transfusion hepatitis in recipients of one- or two-unit blood transfusion between 1971 and 1977. serologic markers of hepatitis b virus (hbv) infection were found in 23 percent, compared to 9.7 percent of 3,230 prospective blood donors. the prevalence of antibody to hepatitis a virus was similar among implicated donors (44%), prospective do ... | 1979 | 230620 |
| histocompatibility antigens in patients with hepatocellular carcinoma and their relationship to chronic hepatitis b virus infection in these patients. | although hepatocellular carcinoma is probably caused by one or more environmental carcinogens, a genetically determined susceptibility to the development of the tumor has not been excluded. in looking for such a predisposition, we have compared the histocompatibility antigens (hla) of 102 southern african blacks with histologically proved hcc with those of 208 healthy blacks. the standard two-stage lymphocyte microcytotoxicity method was used to test for 40 antigens: 17 in the a locus, 20 in the ... | 1979 | 222645 |
| failure to transmit human viral hepatitis types a and b to the congenitally athymic nude mouse. | | 1977 | 202797 |
| viral hepatitis and its effect on pregnancy. | | 1979 | 223787 |
| labeling of hepatitis b virus surface antigen (hbsag) synthesized in a hbsag-producing hepatoma cell line. | hepatitis b virus surface antigen (hbsag) could be studied until recently only by isolating it from the blood of carriers, thus making incorporation of radioactive precursors into this protein(s) impossible. the isolation of a cell line producing hbsag [alexander et al, 1978] has eliminated this obstacle. the cell line was therefore used for labeling hbsag either with 35s-methionine or with 35s-cystine. hbsag was purified by pelleting the component and by isopycnic centrifugation in cscl gradien ... | 1979 | 231637 |
| immunofluorescence studies for hepatitis a virus and hepatitis b surface and core antigen in liver biopsies from patients with acute viral hepatitis. | immunofluorescence studies for hepatitis a virus and hepatitis b surface and core antigen were performed on liver biopsies from 48 patients with acute viral hepatitis. hepatitis a virus was detected in 11 out of 17 patients with type a hepatitis and was not found in patients with type b or non-a non-b hepatitis. hepatitis b surface and core antigens were detected in 2, hepatitis b core antigen alone in 1, and hepatitis b surface antigen alone in 4 out of 24 patients with type b hepatitis. neithe ... | 1979 | 223938 |
| peripheral blood and liver tissue t and b lymphocytes and hepatitis b virus (hbv) | | 1978 | 303581 |
| t-lymphocyte cytotoxicity to hbsag-coated target cells in hepatitis b virus infection. | the cytotoxic effect of peripheral lymphocytes on chicken red blood cells (chrbc) coated with purified hepatitis b surface antigen (hbsag) has been studied as an in vitro parameter of cell-mediated immunity in acute and chronic infection with hepatitis b virus. using this technique, the mean cytotoxic index of lymphocytes from patients with acute hepatitis b (29.13 +/- 20.88) was significantly higher than that obtained with lymphocytes from control subjects (6.53 +/- 3.75). only 33.3% of the pat ... | 1977 | 304824 |
| role of hepatitis b virus in primary liver cancer. | there is an excess prevalence of markers of active infection with hepatitis b virus in patients with primary liver cancer in many parts of the world. early age of infection with hepatitis b virus is likely to be an important factor, resulting in persistent infection that may progress to chronic liver damage. results of recent experimental studies are consistent with integration of hepatitis b viral dna with host cell dna molecules. it is likely that primary liver cancer is the cumulative result ... | 1979 | 224199 |
| [gianotti disease and hepatitis b virus (author's transl)]. | | 1978 | 310483 |
| fibroblast interferon treatment of a patient with chronic active hepatitis. increased number of circulating t lymphocytes and elimination of rosette-inhibitory factor. | a 23 year old woman with chronic active hepatitis documented by liver biopsy demonstrated persistent hepatitis b surface antigen, hepatitis b virus specific dna polymerase hepatitis b core antigen (hbcag), for approximately one year. the number of circulating t lymphocytes that rosetted with sheep erythrocytes was decreased, and a rosette-inhibitory factor was present in her peripheral blood. interferon treatment (1 x 10(6) u/day intramuscularly for 82 days) resulted in a decrease of hbsag and d ... | 1979 | 313705 |
| primary carcinoma of the liver. a histological study of 52 cases from denmark. | among 7763 autopsies performed in greater copenhagen in 1973, there were 309 cases of cirrhosis of the liver and 52 cases of primary carcinoma of the liver (pcl). of the latter, 45 were hepatocellular carcinoma (hcc), 4 combined hcc and cholangiocarcinoma (ccc) and 3 ccc. hcc was found in 7.8 per cent of the cirrhotic livers and was in 57.1 per cent accompagnied by cirrhosis. the criteria of who, peters (modified) and anthony were used for classification. the degree of differentiation of the tum ... | 1979 | 224641 |
| hepatic infections. part ii. the effect of acute and chronic hepatitis b antigenaemia on the reaction to antibodies to sheep red cells (microbial antigens) and human t-activated cells (exposed autologous tissue antigens). | using the agglutination of sheep red cells by human antibodies as an indicator of microbial antibody activity, a highly significant association was found between the response to the e antigen of the hepatitis b virus and the formation of strong antibody levels to microbial substances (chi 2(1) = 33). this kind of association was not found among chronic carriers of the hepatitis b virus who do not produce antibodies to the e antigen (chi 2(1) = 3,7). in the presence of e antigen activity, patient ... | 1979 | 315618 |
| the pathogenesis of hepatitis b: possible mechanisms of viral replication and tissue injury. | | 1980 | 317875 |
| prevalence of antibody to hepatitis a and hepatitis b viruses in selected populations of the south pacific. | five island populations representing the three major cultural groups of the south pacific--polynesia, micronesia, melanesia--were studied for prevalence of antibody to hepatitis a virus (anti-hav) and of antibody to the core antigen of hepatitis b virus (anti-hbc). sera were collected in the late 1950s and early 1960s, selected where possible for appropriate age and sex distributions, and were tested by radioimmunoassay. rather marked differences in prevalence were observed. anti-hbc patterns co ... | 1979 | 224696 |
| acute and chronic hepatitis: multisystemic involvement related to immunologic disease. | | 1977 | 320847 |
| hepatitis b (surface) antigen in mothers and their infants. | hepatitis b (surface) antigen (hbsag) was found in the serum of 8 out of 4 245 women attending the antenatal clinic of the queen victoria maternity hospital seven (0, 16%) were asymptomatic carriers of the antigen, while the eigth suffered from polyarteritis nodosa. seven of the 8 babies born to these mothers were followed-up over periods of up to 18 months, and 1 has become a chronic carrier of hbsag. the antigen was not detected in the colostrum (breast milk) of the 6 positive mothers tested, ... | 1975 | 240207 |
| identification of lymphocytes in percutaneous liver biopsy cores. different t:b cell ratio in hb sag-positive and -negative hepatitis. | the lymphocytes infiltrating the liver were isolated and characterized as t or b cells in three groups of patients: 20 patients with hepatitis b surface antigen (hb sag)-positive acute and chronic hepatitis, 8 patients with hbsag-negative chronic hepatitis with prior evidence for hepatitis b virus (hbv) infection, and 5 patients with hbsag-negative chronic hepatitis without prior evidence for hbv infection. the predominant cell infiltrating the liver was shown to be a t cell in all categories; h ... | 1977 | 323096 |
| letter: possible role of haematophagous insects in the transmission of type b hepatitis. | | 1975 | 241139 |
| [hepatitis b virus and prevention of its transmission]. | | 1978 | 244594 |
| hepatitis b prevalence within a dental student population. | in this descriptive epidemiologic study, prevalence rates of hepatitis b surface antigen (hbsag) and its antibody (anti-hbs) among fourth-year dental students and second-year dental hygiene students were found to be comparable to those of a control population and a local age-adjusted blood donor group. this observation contrasts with the rates reported for practicing dentists, especially oral surgeons, and indicates that the increased risk experienced by dentists after dental school may be attri ... | 1977 | 264921 |
| association of e antigen with dane particle dna in sera from asymptomatic carriers of hepatitis b surface antigen. | sera containing hepatitis b surface antigen from 30 asymptomatic blood donors were assayed for e antigen (hbeag) and antibody to e antigen (anti-hbe) by rheophoresis,. fourteen samples (47%) had detectable hbeag, ten (33%) had anti-hbe, and six (20%) had neither. dna was extracted from 26 of these sera and assayed for its ability to anneal to a [32p]-dna probe that is a copy of dane particle dna. all 10 hbeag-positive samples tested contained dna that formed specific hybrids with the dna probe, ... | 1977 | 266736 |
| rebuttal to a jama editorial: hepatitis b--traffic in the dentist's office. | | 1977 | 267655 |
| [magnius' e-antigen]. | the "e" ag/ac system found by magnius in 1972 is discussed briefly. the new antigen has the same immologic and physiochemical characteristics of hbs and hbc of the hepatitis virus. its existence shows the chronic evolution of the disease in ag hbs carriers. therefore the "e" antigen has a prognostic value in ag hbs carries. | 1977 | 329074 |
| correlation between titer of antibody to hepatitis b core antigen and presence of viral antigens in the liver. | liver specimens of 31 autopsied cases of liver cirrhosis who had had detectable levels of antibody to hepatitis b core antigen (anti-hbc) inthe serum were stained for hepatitis b core antigen (hbcag) and hepatitis b surface antigen (hbsag) by the direct immunofluorescence method. their premortem serum samples were tested for hbsag, antibody to hbsag (anti-hbs) and anti-hbc. persistent hepatitis b virus (hbv) infection as judged by circulating and/or liver hb antigens was identified in 18 patien ... | 1977 | 330306 |
| eukaryotic dna polymerases. | | 1977 | 332062 |
| sex differences in response to hepatitis b infection among patients receiving chronic dialysis treatment. | patients undergoing treatment at a community-based renal dialysis clinic were monitored monthly for hepatitis b surface antigen (hbsag) and antibody to hbsag (anti-hbs). of 160 patients who began treatment hbsag(-)/anti-hbs(-), 77 subsequently became hbsag(+). once hbsag(+), males were more likely to remain hbsag(+) indefinitely, whereas females were more likely to convert to hbsag(-) and develop anti-hbs. this was not due to a sex difference in exposure to hepatitis b virus because only patient ... | 1977 | 267950 |
| an inquiry into the sterilization of dental handpieces relative to transmission of hepatitis b virus. | the transmission of the hepatitis b virus has been implicated in the dental office. the dental profession should be keenly aware of aseptic clinical techniques and effective sterilization procedures. some dental handpieces can be damaged by conventional sterilization procedures. alternative procedures are discussed. a review of currently available handpieces and their appropriate sterilization procedures is presented. | 1978 | 273633 |
| immunological abnormalities associated with liver disease: cause or effect? | immunological abnormalities are demonstrable in patients with various types of liver damage. these may be (a) non-specific and unrelated to pathogenesis, e.g. auto-antibodies such as anti-nuclear factor; (b) specifically directed against liver antigens but not pathogenetic, e.g. cell mediated immune (cmi) reactions to liver antigen as seen in experimental carbon tetrachloride poisoning; (c) of such a nature as to modify the pathology produced by hepatotoxic agents, e.g. hepatitis b virus or alco ... | 1977 | 274938 |
| the genome of hepatitis b virus. | | 1977 | 334041 |
| studies on the subtypes of hepatitis b surface antigen-demonstration of vertical and intrafamilial transmission of hepatitis b virus. | | 1978 | 275454 |
| [comparison between the presence of specific circulating immune complexes and the leukocyte migration inhibition test in different clinical forms of hepatitis b]. | circulating immune complexes were measured by a radioimmunoassay specific for hb complexes in different clinical situations related to hepatitis b virus infection. the leukocyte migration inhibition test (lmit) was performed simultaneously. comparison with the clinical situation suggests that immune complexes are not responsible for the lesions, but that these lesions might be produced by the immunity demonstrated by the lmit. a deficiency of this immunity is responsible for the persistence of i ... | 1977 | 337469 |
| past infection with hepatitis b virus in patients at a dental school. | samples of blood from 327 new patients at a dental school were tested by radioimmunoassay for the presence of hepatitis b surface antigen (hbsag) and hepatitis b surface antibody (anti-hbs). the data were compared to the patients' histories of hepatitis. through a statistical analysis, it was indicated that significant numbers of patients with no history of hepatitis had been infected with hepatitis b virus. | 1978 | 279604 |
| hepatitis viruses. | | 1978 | 340799 |
| [observations on the diffusion of hepatitis a and b virus during an epidemic in a sicilian town with a high rate of infection]. | epidemiological investigations were carried out during a viral hepatitis outbreak occurring in a sicilian town of 30,000 inhabitants with poor sanitary standards, with the aim to study the mode of spread of hav and hbv in conditions of high incidence of infections. hbsag, anti hbs, anti hav (ria), hbeag, anti hbe and anti hbc were investigated in serum samples from patients, their family contacts and from healthy individuals of different age groups. morbidity was inferred from case notifications ... | 1979 | 233297 |
| [diagnosis of hepatitis by means of radioimmunoassay]. | | 1979 | 233368 |
| [physiopathology of hepatitis b virus infection]. | hepatitis b associated antigen (hb-ag) may be observed in the serum in subjects either apparently healthy or exhibiting a number of disease symptoms. its incidence among the geneva voluntary blood donors is 0.48% with 54% exhibiting the surface antigen ad and 34% ay. while the hb-ag positive blood donors appeared clinically healthy, minor pathology was found in the majority of them (thrombocytopenia, histological evidence of inflammatory foci, of persistent hepatitis and of chronic aggressive he ... | 1975 | 240199 |
| serum iron levels and response to hepatitis b virus. | response to hepatitis b virus (hbv) infection [hbv surface antigen (hbsag) and antibody to hbsag (anti-hbs)], serum iron, total iron-binding capacity, hematological status (erythrocytes, hb, and hematocrit), and evidence of liver damage (serum glutamic pyruvic transaminase; aspartate aminotransferase, l-aspartate:2-oxoglutarate aminotransferase, ec 2.6.1.1) were determined for 201 patients on chronic renal dialysis. four factors-serum iron level, transminase level, sex, and hbv response [i.e., i ... | 1979 | 287082 |
| hepatitis b and the dental health professional--an updating. | | 1978 | 289876 |
| restriction endonuclease cleavage map and location of unique features of the dna of hepatitis b virus, subtype adw2. | dna of hepatitis b virus (hbv) of hepatitis b surface antigen (hbsag) subtype adw2 made fully double stranded by the virion dna polymerase and radiolabeled either by the virion dna polymerase reaction or by nick-translation with 32p-labeled deoxynucleoside triphosphates was used to establish a map of restriction endonuclease cleavage sites by the method double and triple enzyme digestion and to determine the relative positions of several unique physical features of this dna. the five restriction ... | 1979 | 291995 |
| [hepatitis b virus and clinical dentistry]. | | 1978 | 295032 |
| the dentist and hepatitis-b virus infection: three-way traffic in the dental surgery. | | 1979 | 296592 |
| t and b lymphocytes in uremic patients with type b hepatitis infection. | peripheral t and b lymphocytes were measured in (1) hepatitis b surface antigen (hbsag)-positive, (2) hbsag-negative uremic patients on chronic hemodialysis (chd) therapy, and (3) patients with type b chronic active viral hepatitis (cavh). when compared to normals, a decrease in the absolute number of t and b lymphocytes was detected in both chd groups. cavh patients had a decrease in the total number of t lymphocytes. when expressed as percentage of t lymphocytes, normals and hbsag-negative chd ... | 1977 | 300854 |
| [significance of the antigen and the anti-e antibody in patients with surface antigen of hepatitis b virus]. | | 1977 | 302013 |
| t-lymphocytes and hepatitis b serology. | the incorporation of 14c-thymidine by peripheral blood lymphocytes stimulated by phytohemagglutinin (pha) and the proportion and absolute number of e-rosettes were determined in 28 prostitutes and the results were correlated with hepatitis b virus (hbv) serology. women were tested for hepatitis b surface antigen (hbsag) and its antibody (anti-hbs) as well as for antibody to the hepatitis b core antigen (anti-hbc). it was found that women who were carriers of hbsag had significantly lower incorpo ... | 1978 | 310427 |
| antibodies to single stranded dna: a diagnostic aid in chronic hepatitis b virus infections. | serial determinations of titers of binding antibodies to single stranded dna were performed over a period of three years in 43 type b hepatitis patients with persisting hbsag who had either developed chronic hepatitis or were asymptomatic carriers. patients with histopathological diagnosis of chronic active or chronic persistent hepatitis, with or without clinical symptoms, showed high titers of anti-dna throughout the course of the disease, whereas in most of these patients the serum alanine tr ... | 1979 | 314970 |
| association of graft survival with host response to hepatitis b infection in patients with kidney transplants. | we studied the relation of host response to hepatitis b infection before transplantation with survival of kidney grafts in 79 patients receiving 87 transplants. antibody to hepatitis b surface antigen (anti-hbs) signaled early graft rejection (median survival congruent to two months), whereas hepatitis b surface antigen (hbsag) signaled delayed rejection (greater than 22 months). patients with neither hbsag nor anti-hbs had graft survival times (median congruent to 16 months) similar to the hbsa ... | 1977 | 318732 |